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Identification

Personal identification

Full name
Martin Vojtek

Citation names

  • Vojtek, Martin

Author identifiers

Ciência ID
5F15-7817-94DC
ORCID iD
0000-0002-9257-7020
Google Scholar ID
4EGxlX0AAAAJ
Researcher Id
AAG-4903-2019

Addresses

  • Faculty of Pharmacy - University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Health Sciences
Outputs

Publications

Conference paper
  1. Ana Cerquido; Martin Vojtek; Olga Viegas; Patricia Dias-Pereira; Carmen Diniz. "Adenosine Overcomes Triple-Negative Breast Cancer Resistance to Platinum-Derived Chemotherapeutic Drugs". 2022.
    10.3390/ECMC2022-13458
  2. Martin Vojtek; Maria P. M. Marques; Ana L. M. Batista de Carvalho; Helder Mota-Filipe; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Palladium-Spermine Complex (Pd2Spm) Triggers Autophagy and Caspase-Independent Cell Death in Triple-Negative Breast Cancer Cells". 2022.
    10.3390/ECMC2022-13469
Conference poster
  1. Martin Vojtek; A.L.M. Batista de Carvalho, M.P.M. Marques, Helder Mota-Filipe, Isabel M.P.L.V.O Ferreira, Carmen Diniz. "Palladium-spermine complex (Pd2Spm) triggers autophagy and caspase-independent cell death in triple-negative breast cancer cells. (PRESENTER)". Paper presented in The 8th International Electronic Conference on Medicinal Chemistry (ECMC 2022), Online, 2022.
  2. Carneiro, TJ; Vojtek, M; Gonçalves-Monteiro, S; Batista de Carvalho, ALM; Marques, MPM; Diniz, C; Gil, AM.. "In vivo 1H NMR metabolomics: Triple-Negative Breast Cancer response to anticancer drug Pd2(Spermine).". Paper presented in 8th International Iberic Biophysics Congress, 2022.
  3. Vojtek, Martin; Salomé Gonçalves-Monteiro, Edgar Pinto, Patrícia Dias-Pereira, Franklim Marques, A.L.M. Batista de Carvalho, M.P.M. Marq. "Anticancer activity of palladium-spermine complex against triple-negative breast cancer (PRESENTER)". Paper presented in 8th European Virtual Congress of Pharmacology (EPHAR2021), 2021.
  4. Carneiro, TJ; Araújo, R; Vojtek, M; Gonçalves-Monteiro, S; Diniz, C; Batista de Carvalho, ALM; Marques, MPM; Gil, AM.. "NMR metabolic profile of the in vivo impact of a potential anticancer drug -Pd(2)spermine.". Paper presented in EUROMAR 2021, 2021.
  5. Carneiro, TJ; Araújo, R; Vojtek, M; Gonçalves-Monteiro, S; Diniz, C; Batista de Carvalho, ALM; Marques, MPM; Gil, AM.. "NMR metabolomics to assess the impact of anticancer drugs cisplatin and Pd(2)spermine on mice organs.". Paper presented in 9th Iberoamerican NMR Meeting, 2021.
  6. Carneiro, TJ; Araújo, R; Vojtek, M; Monteiro, S; Batista de Carvalho, ALM; Pereira, C; Marques, MPM; Gil, AM.. "Nuclear magnetic resonance metabolomics to evaluate the metabolic impact of cisplatin and a potential new anti-cancer drug - Palladium(II)-spermine - In a mouse model.". Paper presented in III International Congress in Health Sciences Research, 2019.
  7. Carneiro, TJ; Araújo, R; Vojtek, M; Monteiro, S; Batista de Carvalho, ALM; Pereira, C; Marques, MPM; Gil, AM.. "NMR metabolomics to assess nephrotoxicity induced by cisplatin and Pd2(spermine) in a mouse model". Paper presented in Jornadas CICECO 2019, 2019.
  8. Vojtek, Martin; Inês Lamego, Edgar Pinto, Agostinho A. Almeida, Isabel M.P.L.V.O. Ferreira, Ana L.M. Batista de Carvalho, M.P.M. Marques. "Anticancer Metal-Polyamine Complexes Against Breast Cancer. (PRESENTER)". Paper presented in 11th Meeting of Young Researchers – University of Porto, 2018.
Journal article
  1. Monika Majirská; Martina Bago Pilátová; Zuzana Kudlicková; Martin Vojtek; Carmen Diniz. "Targeting hematological malignancies with isoxazole derivatives". Drug Discovery Today 29 (2024): 104059.
    Open access • Published • 10.1016/j.drudis.2024.104059
  2. Tatiana J. Carneiro; Ana L. M. Batista de Carvalho; Martin Vojtek; Raquel C. Laginha; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Pd2Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer". Journal of Medicinal Chemistry 67 (2024): 6839-6853.
    Open access • 10.1021/acs.jmedchem.4c00435
  3. Carneiro, Tatiana J.; Carvalho, Ana L. M. Batista; Vojtek, Martin; Carmo, Inês F.; Marques, Maria Paula M.; Diniz, Carmen; Gil, Ana M.. "Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics". Cancer Cell International 23 1 (2023): http://dx.doi.org/10.1186/s12935-023-03124-0.
    10.1186/s12935-023-03124-0
  4. Martin Vojtek; Clara B. Martins; Raquel Ramos; Sara Gomes Duarte; Isabel M. P. L. V. O. Ferreira; Ana L. M. Batista de Carvalho; M. Paula M. Marques; Carmen Diniz. "Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity towards TNBC-Sensitive and -Resistant to Cisplatin". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041205.
    10.3390/pharmaceutics15041205
  5. Tatiana J. Carneiro; Martin Vojtek; Salomé Gonçalves-Monteiro; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232213773.
    10.3390/ijms232213773
  6. Ana Sofia Cerquido; Martin Vojtek; Rita Ribeiro-Oliveira; Olga Viegas; Joana Beatriz Sousa; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Unravelling Potential Health-Beneficial Properties of Corema album Phenolic Compounds: A Systematic Review". Pharmaceuticals (2022): https://doi.org/10.3390/ph15101231.
    10.3390/ph15101231
  7. Ana Sofia Cerquido; Martin Vojtek; Rita Ribeiro-Oliveira; Salomé Gonçalves-Monteiro; Maria João Barroca; Aida Moreira da Silva; Olga Viegas; et al. "Corema album Leaves Mediate DNA Damage in Triple-Negative Breast Cancer Cells". Current Issues in Molecular Biology (2022): https://doi.org/10.3390/cimb44080246.
    10.3390/cimb44080246
  8. Tatiana J. Carneiro; Martin Vojtek; Salomé Gonçalves-Monteiro; João R. Neves; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of Healthy Mice". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14020259.
    10.3390/pharmaceutics14020259
  9. Martin Vojtek; Salomé Gonçalves-Monteiro; Patrícia Seminská; Katarína Valová; Loreto Bellón; Patrícia Dias-Pereira; Franklim Marques; et al. "Pd2Spermine Complex Shows Cancer Selectivity and Efficacy to Inhibit Growth of Triple-Negative Breast Tumors in Mice". Biomedicines (2022): https://doi.org/10.3390/biomedicines10020210.
    10.3390/biomedicines10020210
  10. Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Impact of the Pd2Spm (Spermine) Complex on the Metabolism of Triple-Negative Breast Cancer Tumors of a Xenograft Mouse Model". International Journal of Molecular Sciences 22 19 (2021): 10775-10775. https://doi.org/10.3390/ijms221910775.
    10.3390/ijms221910775
  11. Salomé Gonçalves-Monteiro; Rita Ribeiro-Oliveira; Maria Sofia Vieira-Rocha; Martin Vojtek; Joana B. Sousa; Carmen Diniz. "Insights into Nuclear G-Protein-Coupled Receptors as Therapeutic Targets in Non-Communicable Diseases". Pharmaceuticals 14 5 (2021): 439-439. https://doi.org/10.3390/ph14050439.
    10.3390/ph14050439
  12. Martin Vojtek; Salomé Gonçalves-Monteiro; Edgar Pinto; Sára Kalivodová; Agostinho Almeida; Maria P. M. Marques; Ana L. M. Batista de Carvalho; et al. "Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd2Spm) in Mice". Pharmaceuticals 14 2 (2021): 173-173. https://doi.org/10.3390/ph14020173.
    10.3390/ph14020173
  13. Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Carmen Diniz; Ana L. M. Batista de Carvalho; M. Paula M. Marques; Ana M. Gil. "Novel Insights into Mice Multi-Organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent". Metabolites 11 2 (2021): 114-114. https://doi.org/10.3390/metabo11020114.
    10.3390/metabo11020114
  14. Martin Vojtek; Edgar Pinto; Salomé Gonçalves-Monteiro; Agostinho Almeida; M. P. M. Marques; Helder Mota-Filipe; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies". Analytical Methods (2020): https://doi.org/10.1039/D0AY01328E.
    10.1039/D0AY01328E
  15. Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Carmen Diniz; Ana L.M. Batista de Carvalho; Maria Paula M. Marques; Ana M. Gil. "Multi-Organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisplatin in Mice". Metabolites 9 11 (2019): 279-279. https://doi.org/10.3390/metabo9110279.
    10.3390/metabo9110279
  16. Rita Ribeiro-Oliveira; Martin Vojtek; Salomé Gonçalves-Monteiro; Maria Sofia Vieira-Rocha; Joana B. Sousa; Jorge Gonçalves; Carmen Diniz. "Nuclear G-protein-coupled receptors as putative novel pharmacological targets". Drug Discovery Today (2019): https://doi.org/10.1016/j.drudis.2019.09.003.
    10.1016/j.drudis.2019.09.003
  17. Ana Sousa-Oliveira; Ana Brandão; Martin Vojtek; Salomé Gonçalves-Monteiro; Joana B. Sousa; Carmen Diniz. "Vascular impairment of adenosinergic system in hypertension: increased adenosine bioavailability and differential distribution of adenosine receptors and nucleoside transporters". Histochemistry and Cell Biology 151 5 (2019): 407-418. https://doi.org/10.1007/s00418-018-1743-0.
    10.1007/s00418-018-1743-0
  18. Olga Viegas; Miguel A. Faria; Joana B. Sousa; Martin Vojtek; Salomé Gonçalves-Monteiro; Joanna Suliburska; Carmen Diniz; Isabel M.P.L.V.O. Ferreira. "Delphinidin-3-O-glucoside inhibits angiogenesis via VEGFR2 downregulation and migration through actin disruption". Journal of Functional Foods 54 (2019): 393-402. https://doi.org/10.1016%2Fj.jff.2019.01.039.
    10.1016/j.jff.2019.01.039
  19. Vojtek M; Marques MPM; Ferreira IMPLVO; Mota-Filipe H; Diniz C. "Anticancer activity of palladium-based complexes against triple-negative breast cancer.". Drug discovery today (2019): http://europepmc.org/abstract/med/30849441.
    10.1016/j.drudis.2019.02.012
  20. Laranjeira P; Duque M; Vojtek M; Inácio MJ; Silva I; Mamede AC; Laranjo M; et al. "Amniotic membrane extract differentially regulates human peripheral blood T cell subsets, monocyte subpopulations and myeloid dendritic cells.". Cell and tissue research (2018): http://europepmc.org/abstract/med/29582167.
    10.1007/s00441-018-2822-1
Report
  1. Ana Sofia Cerquido; Martin Vojtek; Rita Ribeiro-Oliveira; Olga Viegas; Joana Beatriz Sousa; Isabel M.P.L.V.O. Ferreira; Carmen Diniz. 2022. Unravelling potential health-beneficial properties of Corema album phenolic compounds: a systematic review. https://doi.org/10.37766/inplasy2022.8.0022.
    10.37766/inplasy2022.8.0022
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/10 Development of Palladium-spermine complex (Pd2Spm) for triple-negative breast cancer cells – in vitro and in vivo X Congresso Iberoamericano de Ciências Farmacêuticas
FFUC (Coimbra, Portugal)
2020/02 Anticancer palladium-spermine complex: in vivo activity against triple-negative breast cancer in mice SPF 2020 – Reunião Anual daSociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/02 Novel cost-effective ICP-MS method for pharmaco-toxicokinetic studies ofplatinum and palladium-based drugs in animal tissues XLIX Reunião Anual da SociedadePortuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVII Reunião de Toxicologia
Sociedade Portuguesa Farmacologia (Porto, Portugal)
2018/02 Anticancer Metal Complexes with Polyamines Against Breast Cancer: Cellular Drug Uptake and Selective Cytotoxicity XLVIII Annual Meeting of Portuguese Pharmacological Society, XXXVI Clinical Pharmacology, XVII Toxicology
(Lisbon, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/02 - Current Unlocking Triple-Negative Breast Cancer resistance in 3D models
Supervisor of Beatriz M.
 Bioquímica
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/02/01 - 2022/07/01 Impact of the Nucleoside Adenosine in Triple-Negative Breast Cancer
Co-supervisor of Andreia S.
 Bioquímica (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/01/01 - 2021/07/25 Strategies to Combat the Resistance of Breast Cancer Cells - Combination of Platinum(II)-based Drugs with Adenosine
Supervisor of Sara D.
 Biotecnologia Medicinal (Degree)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/01/01 - 2021/07/25 Anticancer Activity of Novel Trinuclear Platinum(II)- and Palladium(II)-based Complexes with Spermidine against Breast Cancer
Co-supervisor of Raquel R.
 Biotecnologia Medicinal (Degree)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2020/01/01 - 2020/07/30 Antioxidant and Anti-inflammatory Activities Exerted by Phenolic Compounds Extracted from Corema album Leaves
Supervisor of Ana S. C.
 Bachelor degree in Biochemistry (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/02/06 - 2019/02/08 XLIX Reunião Anual da SociedadePortuguesa de Farmacologia, XXXVIIReunião de Farmacologia Clínica e XVIIReunião de Toxicologia (2019/02/06 - 2019/02/08)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/11/15 - 2021/12/03 Training programme in design thinking, startup, customer service delivery and innovative project. Total duration of 30 hours (online).
Seminar
 Doctor'Preneuriales training programme
Université Paris-Saclay, France

Ad Hoc journal article review

Journal title (ISSN) Publisher
2020/12/01 - Current Cancers MDPI
2020/12/01 - Current Molecules MDPI
2020/12/01 - Current Future Pharmacology MDPI
2020/12/01 - Current International Journal of Molecular Sciences MDPI
2020/12/01 - Current Cardiovascular Toxicology Springer Nature
2020/12/01 - Current Brazilian Journal of Pharmaceutical Sciences University of Sao Paolo

Association member

Society Organization name Role
2019 - Current Portuguese Society of Pharmacology Member

Mentoring / Tutoring

Topic Student name
2023/09 - 2024/02 Supervision of Scientific Mobility Internship - PhD student Monika M.
2020/09 - 2020/12 Scientific internship of recent graduates in Pharmacy (Erasmus+) Annamária L.
2020/06 - 2020/12 Scientific internship of recent graduates in Pharmacy (Erasmus+) Monika M.
2019/10 - 2020/05 Scientific internship of recent graduates in Pharmacy (Erasmus+) Sara K.
2019/07 - 2019/09 Scientific internship of recent graduates in Pharmacy (Erasmus+) Maria D.
2019/07 - 2019/09 Scientific internship of recent graduates in Pharmacy (Erasmus+) Zuzana K.
2019/01 - 2019/08 Scientific internship of recent graduates in Pharmacy (Erasmus+) Katarína V.
2019/01 - 2019/07 Scientific internship of Pharmacy students (Erasmus+) Patrícia S.
2018/05 - 2018/08 Scientific internship of recent graduates in Pharmacy (Erasmus+) Andrea S.