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Francisco Miguel Piçarra Leisico. Completed the Mestrado in Molecular Biotecnology in 2014 by Universidade de Aveiro. Attends the Doutoramento in PhD Program in Molecular Biosciences by REQUIMTE Unidade de Ciências Biomoleculares Aplicadas since 2015/01/05. Is Postdoc in Paul Scherrer Institut PSI. Published 7 articles in journals. Organized 1 event(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry. In their professional activities interacted with 50 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: X-ray Crystallography; Small-angle X-ray scattering; Molecular machines; Cryo-EM; G-Protein Couple Receptors; .
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Identification

Personal identification

Full name
Francisco Miguel Piçarra Leisico

Citation names

  • Leisico, Francisco

Author identifiers

Ciência ID
5F1B-CEC0-4B77
ORCID iD
0000-0002-4672-4659

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Proficiency (C2) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
French Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Beginner (A1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2015/01/05 - 2022/07/20
Ongoing
 PhD Program in Molecular Biosciences (Doutoramento)
Major in Structural Biochemistry
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
"Unraveling the enzymatic mechanism of glutamate amidation in Staphylococcus aureus peptidoglycan" (THESIS/DISSERTATION)
2014
Concluded
 Molecular Biotecnology (Mestrado)
Universidade de Aveiro, Portugal
"Discovery of pathogenicity markers in Bursaphelenchus xylophilus" (THESIS/DISSERTATION)
 18/20
Affiliation

Science

Category
Host institution 		Employer
2023/12/01 - Current Postdoc (Research) Paul Scherrer Institut PSI, Switzerland
2021/09/01 - 2023/10/31 Postdoc (Research) Centre National de la Recherche Scientifique, France
Institut de Biologie Structurale, France
2019/04/15 - 2019/10/15 Research Assistant (Research) European Molecular Biology Laboratory, France
European Molecular Biology Laboratory, France
2013/09/02 - 2014/12/19 Contracted Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Others

Category
Host institution 		Employer
2015/01/05 - 2022/07/20 PhD student REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Projects

Grant

Designation Funders
2024/07 - 2026/06 Structural characterization of melanopsin for developing optogenetic tools
225029
 Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
2018/09 - 2022/09 Geradores Energéticos Bacterianos Multitarefa do tipo ABC: uma ATPase serve todos?
151888PRJ
 Fundação para a Ciência e a Tecnologia
2018/10 - 2022/03 Amidação do Peptidoglicano - um alvo versátil para o sucesso no combate a Staphylococcus aureus
152875PRJ
 Fundação para a Ciência e a Tecnologia
2018/10 - 2021/10 StaphOUT - Fighting Staphylococcus aureus - Peptidoglycan amidation as a new target
PTDC/BIA-MIC/31645/2017
 Fundação para a Ciência e a Tecnologia
2018 - 2021 BACTERIAL ABC-TYPE MULTITASK ENERGIZERS: ONE ATPASE FITS ALL?
PTDC/BIA-MIC/30696/2017
 Fundação para a Ciência e a Tecnologia
2019/01 - 2019/12 Unidade de Ciências Biomoleculares Aplicadas
154717UID
 Fundação para a Ciência e a Tecnologia
2016/01 - 2018/12 Carbon monoxide guided shuttles (COGSs) to fight Rheumatoid Arthritis
Provided by PTCRIS: 129378
Provided by PTCRIS: 140528
 Fundação para a Ciência e a Tecnologia, I.P.
2015/01 - 2018/12 Unraveling the enzymatic mechanism of glutamate amidation in Staphylococcus aureus peptidoglycan
39296DFA
 Fundação para a Ciência e a Tecnologia
2012/02 - 2015/04 Nitric Oxide Synthase targeting with Re(I)/99mTc(I)-complexes containing L-Arg derivatives: A structure-activity study
Provided by PTCRIS: 121752
 Fundação para a Ciência e a Tecnologia, I.P.
Outputs

Publications

Journal article
  1. Paquete-Ferreira J; Leisico F; Correia MAS; Engrola FSS; Santos-Silva T; Santos MFA. "Using Small-angle X-ray Scattering to Characterize Biological Systems: A General Overview and Practical Tips.". Methods in molecular biology (Clifton, N.J.) (2023): http://europepmc.org/abstract/med/37093488.
    10.1007/978-1-0716-3147-8_22
  2. Engrola FSS; Paquete-Ferreira J; Santos-Silva T; Correia MAS; Leisico F; Santos MFA. "Screening of Buffers and Additives for Protein Stabilization by Thermal Shift Assay: A Practical Approach.". Methods in molecular biology (Clifton, N.J.) (2023): http://europepmc.org/abstract/med/37093477.
    10.1007/978-1-0716-3147-8_11
  3. Francisco Leisico; Juneina Omeiri; Christine Le Narvor; Joël Beaudouin; Michael Hons; Daphna Fenel; Guy Schoehn; et al. "Structure of the human heparan sulfate polymerase complex EXT1-EXT2". Nature Communications (2022): https://doi.org/10.1038/s41467-022-34882-6.
    10.1038/s41467-022-34882-6
  4. "Multitask ATPases (NBDs) of bacterial ABC importers type I and their interspecies exchangeability". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-76444-0.
    10.1038/s41598-020-76444-0
  5. Cécile Morlot; Daniel Straume; Katharina Peters; Olav A. Hegnar; Nolwenn Simon; Anne-Marie Villard; Carlos Contreras-Martel; et al. "Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae". Nature Communications (2018): https://doi.org/10.1038/s41467-018-05602-w.
    10.1038/s41467-018-05602-w
  6. Francisco Leisico; Diana V. Vieira; Teresa A. Figueiredo; Micael Silva; Eurico J. Cabrita; Rita G. Sobral; Ana Madalena Ludovice; et al. "First insights of peptidoglycan amidation in Gram-positive bacteria - the high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-22986-3.
    10.1038/s41598-018-22986-3
  7. Trouve J; Mohamed A; Leisico F; Contreras-Martel C; Liu B; Mas C; Rudner DZ; Rodrigues CDA; Morlot C. "Structural characterization of the sporulation protein GerM from Bacillus subtilis.". Journal of structural biology (2018): http://europepmc.org/abstract/med/30266596.
    10.1016/j.jsb.2018.09.010
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/03/20 Structural and functional studies on Staphylococcus aureus MurT-GatD heterodimer 3rd Annual Users Meeting of iNEXT
iNEXT: Infrastructure for NMR, EM and X-rays for Translational Research (Grenoble, France)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018 - 2018 UCIBIO Annual Meeting (2018 - 2018) (2018 - 2018)
Meeting (Member of the Organising Committee)
 REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal