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Ana Luísa Cardoso graduated in Biochemistry from the University of Coimbra (UC) in 2004, being awarded a merit prize as one of the top 3% top students of the Faculty for Science and Technology of UC. In the same year, she received a Ph.D. scholarship from the Portuguese Science Foundation (FCT) and initiated her Ph.D. under the supervision of Prof. Dr. Conceição Pedroso de Lima at the Biochemistry Department of UC. Between 2004 and 2008 she worked in the development of lipid-based nanoparticles for siRNA delivery to the CNS, aiming at generating new therapeutic tools for the treatment of acute brain lesions. During her Ph.D. project, she had the opportunity to work with Prof. Ernst Wagner and Dr. Carsten Culmsee, at the Faculty of Pharmacy of Ludwig-Maximillian University (LMU) and with Prof. Dr. Nikolaus PLesnila, at the Institute for Stroke and Dementia Research (LMU) in Munich, between 2006 and 2007. After obtaining her Ph.D. in Biochemical Technology (2008), Ana Cardoso integrated the Center for Neuroscience and Cell Biology (CNC) as a Post Doc, where she investigated the role of miRNA deregulation in CNS diseases, including glioblastoma and Alzheimer's disease (AD). In 2012, Ana Cardoso was awarded a grant from FCT to develop a new lentiviral-based platform to modulate miRNAs in AD animal models, aiming at decreasing APP and BACE levels and improving neuronal deficits. As a result of her efforts, in 2013, she was selected to integrate the project New Strategies to Manage Brain Diseases, assuming a two-year position as an Invited Auxiliary Investigator at UC. From 2013 to 2015 Ana Cardoso took her first steps as an independent scientist, focusing her research in the field of neuroimmunology, and publishing her first papers as the corresponding author. In 2016 she was awarded a second Pos Doc fellowship to continue to investigate the contribution of miRNAs to the modulation of innate immune responses. During her career, Ana Cardoso has worked with several national and international Ph.D. and Master Programs, successfully supervising 12 Master students and 4 Ph.D. students and organizing/participating in several Advanced Courses in Neurosciences, Gene Therapy, and Epigenetics, both at CNC and in other Portuguese Institutions. In 2017, Ana Cardoso accepted a new professional challenge and integrated, as a Senior Investigator, the recently formed Neuronal Circuits and Behavior Group, led by Dr. João Peça. Her most recent work has been focused on understanding the crosstalk between the immune system and neuronal homeostasis mechanisms, with the ultimate goal of unveiling the role of stress-triggered neuroinflammatory events in synaptic architecture and the development of neuropsychiatric and neurodegenerative disorders. Since 2005 Ana Luísa Cardoso has published 46 peer-reviewed papers and 7 book chapters (over 2500 citations; h-index of 27), 9 as the last/corresponding author. In the last 5 years, she has attained competitive funding as a Principal Investigator from both national and international agencies (FCT, Bial Foundation, Takeda).
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Identification

Personal identification

Full name
Ana Luísa Colaço Cardoso

Citation names

  • Cardoso, Ana

Author identifiers

Ciência ID
6014-DF87-87A1
ORCID iD
0000-0001-5145-4561

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
French Beginner (A1) Intermediate (B1) Intermediate (B1) Beginner (A1)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2010/04 - 2010/06
Concluded
 Curso de Formação Inicial de Formadores (Curso de Especialização Tecnológica)
Instituto do Emprego e Formação Profissional, Portugal
2009/09/08 - 2009/09/19
Concluded
 Course in Laboratorial Animal Science (Pós-Graduação)
Direcção-Geral de Alimentação e Veterinária, Portugal
2008/07/10
Concluded
 Bioquímica (Doutoramento)
Major in Especialidade: Tecnologia Bioquímica
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Gene Silencing as a Promising Strategy for Neuroprotection: on the Development of a Lipid-based System for the Delivery of Sirnas to the Central Nervous System" (THESIS/DISSERTATION)
 Aprovado com Louvor e Distinção por Unanimidade
2008/02 - 2008/05
Concluded
 Technologic Entrepreneurship Course (Pós-Graduação)
Universidade de Coimbra, Portugal
2004/06/30
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Tf-lipoplex-mediated NGF gene transfer to the CNS: neuroprotection and recovery in an excitotoxic model of brain injury" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2019/01/01 - Current Researcher (Research) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2016/01/01 - 2019/01/14 Postdoc (Research) CNC.IBILI, Portugal
2013/11/01 - 2015/06/30 Invited Auxiliary Researcher (Research) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2009/01/01 - 2013/09/10 Postdoc (Research) CNC.IBILI, Portugal

Others

Category
Host institution 		Employer
2006/09/01 - 2007/07/31 Visiting Scholar Ludwig-Maximilians-Universitat Munchen, Germany
Ludwig-Maximilians-Universitat Munchen, Germany
2003/09/01 - 2004/07/31 Internship at the Center for Neuroscience and Cell Biology (Vectors and Gene Therapy Group) CNC.IBILI, Portugal
Projects

Grant

Designation Funders
2024/06/01 - 2025/01/31 Empathic Spaces - Immersive VR architectural installation for mental health awareness.
168
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Universidade de Coimbra
Ongoing

Contract

Designation Funders
2023/03/01 - Current Th2brain: Effects of Th2-related immunity in the postnatal maturation of brain circuits
2022.02604.PTDC
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/15 - 2025/01/14 Unraveling miRNA contribution to neuroinflammation and dementia
DL 57/2016/CP1448/CT0023
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/02/01 - 2024/01/31 Postnatal Reorganization of the cerebellum via Neuron-microglia interaction: IL-4 as a mediator between ADHD and allergies
PTDC/MED-NEU/5993/2020
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2023/12/31 Disease modelling of frontotemporal dementia in human brain organoids
PTDC/MEC-NEU/4814/2020
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2023/04/30 Evaluation of TETO-OSKM lentiviral constructs in Dementia models
CSD1010A01#IV1010
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 YouthBio Therapeutics
Ongoing
2022/03/01 - 2023/03/31 BrainCils: Neuronal primary cilia and chromatin dysregulation - Exploring the missing link in neurodevelopmental disorders using brain organoids
EXPL/MED-OUT/1470/2021
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/03 - 2023/03 BrainCils: Neuronal primary cilia and chromatin dysregulation - Exploring the missing link in neurodevelopmental disorders using brain organoids
EXPL/MED-OUT/1470/2021
 Fundação para a Ciência e a Tecnologia
2021/03/01 - 2022/12/31 Does healthy microglia rescue neuroinflammation and synaptic dysfunction in human cerebral organoids with FTD-associated mutations?
EN119
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Takeda Pharmaceuticals Asia Pacific Pte Ltd
Ongoing
2018/07/26 - 2021/07/25 The neuroinflammatory reaction to acute systemic inflammation during delirium and its impact in the cognitive trajectory and progression to dementia: a case-control longitudinal study using imaging and molecular biomarkers
PTDC/MEC-PSQ/32501/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/04/01 - 2019/10/01 Social hierarchy and early life adversity: optogenetic modulation of prefrontal cortical circuits and neuroepigenetic regulation
PTDC/NEU-SCC/3247/2014
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/01/01 - 2019/01/14 Understanding the contribution of miRNAs to neuroinflammation in Alzheimer´s disease
SFRH/BPD/108312/2015
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/03/01 - 2015/08/31 Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease
PTDC/BIM-MEC/0651/2012
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/03/02 - 2015/06/01 Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery
PTDC/DTP-FTO/0265/2012
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/03 - 2015/03 Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery
Provided by PTCRIS: 124488
124488
 Fundação para a Ciência e a Tecnologia, I.P.
2013/01/01 - 2014/12/31 PROJECTO ESTRATÉGICO - LA 1 - 2013-2014 PEst-C/SAU/LA0001/2013
PEst-C/SAU/LA0001/2013
Researcher
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2013/10/31 INFLAMMATORY MECHANISMS IN NEURODEGENERATION: MIRNAS AS REGULATORS OF THE IMMUNE SYSTEM RESPONSE IN ALZHEIMERS DISEASE
SFRH/BPD/46228/2008
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/05/01 - 2010/12/31 Development of novel approaches for anti-tumor therapy based on the S413-PV cell penetrating peptide to improve the intracellular delivery of therapeutic nucleic acids and proteins
PTDC/BIO/65627/2006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/01/01 - 2008/12/31 SILENCIAMENTO DE GENES PRÓ-APOPTÓTICOS PARA O TRATAMENTO DA LESÃO CEREBRAL: DESENVOLV. DE VECTORES DE BASE LIPÍDICA PARA POTENCIAR A ENTREGA DE SIRNA E DE GENES CODIFICADORES DE SIRNA NUM MODELO NEURONAL DE ISQUÉMIA
SFRH/BD/17216/2004
PhD Student Fellow
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Trabulo, S.; Cardoso, A.L.; Cardoso, A.M.S.; Düzgünes, N.; Jurado, A.S.; De Lima, M.C.P.. Cell-penetrating peptide-based systems for nucleic acid delivery: A biological and biophysical approach. 2012.
    10.1016/B978-0-12-391858-1.00014-9
  2. Cardoso, A.; Trabulo, S.; Moreira, J.N.; Düzgünes, N.; de Lima, M.C.P.. Chapter 14 Targeted Lipoplexes for siRNA Delivery. 2009.
    10.1016/S0076-6879(09)65014-X
Book chapter
  1. Cardoso, Ana L.; Guedes, Joana R.. "Quantifying miRNA Deregulation in Alzheimer’s Disease". In Biomarkers for Alzheimer’s Disease Drug Development, 307-319. Springer New York, 2018.
    10.1007/978-1-4939-7704-8_21
  2. Cardoso, Ana M.; Cardoso, Ana L.; Pedroso de Lima, Maria C.; Jurado, Amalia S.. "Nonviral Therapeutic Approaches for Modulation of Gene Expression: Nanotechnological Strategies to Overcome Biological Challenges". In Nanoparticles in Life Sciences and Biomedicine, 409-440. Pan Stanford, 2018.
    10.1201/9781351207355-14
  3. Cardoso, A.M.; Guedes, J.R.; Cardoso, A.L.; Morais, C.; Cunha, P.; Viegas, A.T.; Costa, R.; Jurado, A.; Pedroso de Lima, M.C.. "Recent Trends in Nanotechnology Toward CNS Diseases: Lipid-Based Nanoparticles and Exosomes for Targeted Therapeutic Delivery". In Gene Therapy. 2016.
    10.1016/bs.irn.2016.05.002
  4. Guedes, J.; Viegas, A.T.; Pedroso de Lima, M.C.; Cardoso, A.L.. "Microglia: A double-edged sword for Alzheimer's disease". In Gene Therapy. 2015.
  5. Cardoso, Ana. "Interaction of nucleic acids with biological membranes: activation of inflammatory mechanisms". In A Toxicological / Pharmacological Approach to the Chemico-Biological Interactions at the Membrane Level, edited by Jurado A.S.. Translational Research Network, 2013.
    Published
  6. Faneca, Henrique; Cardoso, Ana Luísa; Trabulo, Sara; Duarte, Sónia; de Lima, Maria C. Pedroso. "Cationic Liposome-Based Systems for Nucleic Acid Delivery: From the Formulation Development to Therapeutic Applications". In Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment, 153-184. Springer Netherlands, 2013.
    10.1007/978-94-007-6010-3_6
  7. Cardoso, A.L.; Trabulo, S.M.; Duarte, S.P.; Costa, P.M.; Almeida, L.P.; de Lima, M.C.P.. "Gene silencing as a promising strategy to target CNS and neurological disorders". In Gene Therapy. 2009.
Conference paper
  1. Sequeira, Diana; Cardoso, Ana; Peça, João; Palma, Paulo; Santos, João Miguel. "The effect of calcium silicate-based cements on viability of stem cells within the apical papilla". Paper presented in 17° Biennal Congress of the European Society of Endodontology, Barcelona, 2015.
Conference poster
  1. Neves, Mafalda; Martins, Solange; Cardoso, Ana. Corresponding author: Cardoso, Ana. "Generation and characterization of induced pluripotent stem cells derived from human dermal fibroblast lines". Paper presented in FENS Regional Meeting, 2023.
  2. Martins, Solange; Neves, Mafalda; Cardoso, Ana. Corresponding author: Cardoso, Ana. "Immunocompetent brain organoids to study the pathological mechanisms of Frontotemporal Dementia". Paper presented in FENS Regional Meeting, 2023.
  3. Cardoso, Ana. "Postnatal L-4 administration induces long-term dysfunction in cerebellar-VTA connectivity". Paper presented in 9th FENS Forum, 2022.
  4. Cardoso, Ana. "Exploring the missing link between neuronal primary cilia dysfunction and neurodevelopmental disorders - hints from dental stem cell-derived brain organoids". Paper presented in 9th FENS Forum, 2022.
  5. Cardoso, Ana. "Allergies and IL-4 shape postnatal cerebellar development via microglia-mediated neuronal pruning to induce ADHD-like behaviors in mice". Paper presented in 9th FENS Forum, 2022.
  6. Cardoso, Ana. "Exposure to early-life stress promotes sex-dependent changes in microglia morphology and phagocytic activity in the prefrontal cortex". Paper presented in 9th FENS Forum, 2022.
  7. Cardoso, Ana. "Early-life adversity induces sex-specific dysfunction of the mOFC and leads to impulsive, hyperactive, and risk-taking behaviours in juvenile male mice". Paper presented in 9th FENS Forum, 2022.
  8. Costa, Jéssica; Cardoso, Ana. "The influence of maternal bonding in neuroimmune synaptic function". Paper presented in 13º Symposium of Bial Foudation ¿ Behind and Beyond the Brain; The mystery of time, 2022.
  9. Cardoso, Ana. "Early life stress and social hierarchies: The role of cortico-striatal circuits". Paper presented in 13th Symposium of Bial Foundation, 2022.
  10. Cardoso, Ana. "The influence of maternal bonding in neuroimmune synaptic function”,". Paper presented in 13th Symposium of Bial Foundation,, 2022.
  11. Cardoso, Ana; Guedes, Joana; Ferreira, António Pedro A.; João Miguel Peça. "Abnormal microgia-mediated prunning in the cerebellum induces circuitry and behavioral disfunction in mice". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  12. Cardoso, Ana; Mariana, Laranjo; Peça, João. "Dissecting the role of parvalbumin-positive inhibitory neurons in the cellular and behavioural phenotypes associated with Gprasp2 deletion". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  13. Gomes, Marcos; Pereira, Marta; Laranjo, Mariana; Reis, Tiago; Cardoso, Ana Maria; Ferreira-Marques, Marisa; Aveleira, Célia; et al. "GPRASP2 (dys)function in metabolism and obesity". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  14. Regueira, Patrícia; Silva, Ana Rita; Cardoso, Ana; Santana, Isabel; Cerejeira, Joaquim. "Unravelling the effect of peripheral inflammatory markers as a predictor of cognitive decline in delirious patients". Paper presented in 20th WPA WORLD CONGRESS OF PSYCHIATRY, 2021.
  15. Cardoso, Ana; Costa, Jéssica; Martins, Solange; Ferreira, P.A.; Guedes, J. R.; Carvalho, MJ; Peça, João. "Early-life stress causes sex-dependent changes in microglia function, circuit wiring and behavior in the mPFC". Paper presented in 12th FENS Forum of Neuroscience, Glasgow, Scotland, 2020.
  16. Seabra, Catarina; Oliveira, Ana Rafaela; Guedes, J.; Cardoso, AL; Sequeira, D; Palma, P; Santos, JM; Oliveira, G; Peça, JM. "Modelling the Neurogenetics of Neurodevelopmental Disorders - Hints from organoids". Paper presented in Meeting of the Portuguese Society of Human Genetics, 2019.
  17. Costa, Jéssica; Ferreira, António Pedro de Azevedo; Guedes, Joana R.; Franco, Lara; Peça, João M.; Cardoso, Ana. "Early-life stress causes behaviour changes and microglia dysfunction in the pre-frontal cortex of male mice". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
  18. Guedes, J; Ferreira, António Pedro A.; Costa, J; Pereira, Marta; Cardoso, AL; Peça, J. "IL-4 skews the microglial developmental program during cerebellar maturation". Paper presented in Portuguese Society for Neuroscience, 2019.
  19. Seabra, Catarina; Oliveira, Ana R.; Guedes, Joana R.; Sequeira, Diana; Palma, Paulo J.; Santos, João Miguel; Duque, Frederico; et al. "Production and testing of human-derived neurons and brain organoids: advanced model probing in neurodevelopmental disorders". Paper presented in Meeting of the Portuguese Society for Neuroscience, 2019.
  20. Guedes, Joana R.; Ferreira, António Pedro A.; Costa, Jéssica; Pereira, Marta; Cardoso, Ana; Peça, João M.. "Microglia-dependent remodelling of cerebellar circuits". Paper presented in Gordon Research Conference on Neuroimmune Communication in Health and Disease, 2019.
    10.1109/ipcc.1993.593861
  21. Costa, Jéssica; Guedes, J. R.; Ferreira, P.A.; Franco, Lara Oliveira; Peça, João; Cardoso, Ana. "Early-life stress causes behavior changes and microglia dysfunction in the pre-frontal cortex of male mice". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
  22. Guedes, J. R.; Ferreira, P.A.; Costa, Jéssica; Pereira, Marta; Cardoso, Ana; Peça, João. "Microglia-dependent remodeling of cerebellar circuits". Paper presented in Gordon Research Conference - Neuroimmune Communication in Health and Disease, Exploring Neuroimmunology: From Single Cells to Organisms, 2019.
  23. Franco L., Edfawy L., Pereira M., Laranjo M.,; Cardoso, Ana; Peça, João M.. "Golgi-like labelling and sparse tagging of neurons using peripheral administration of AAVs". Paper presented in 52º International Congress on Microscopy and Microanalysis, 2018.
  24. A.T. Viegas, V. Carmona, J. Guedes, A.R. Oliveira, L. Pereira de Almeida, C. Resende Oliveira, J.P. de Magalhães, J. P; Cardoso, Ana. "MicroRNA modulation: a promising therapeutic strategy for Alzheimer’s disease". Paper presented in 4th International Conference on Molecular Neurodegeneration (ICMN 2016): Novel Systems and Emerging Concepts, 2016.
  25. Cardoso, Ana. "Using miRNA modulation to target amyloid-ß cascade in Alzheimer’s disease". Paper presented in Biology of Ageing Conference, 2015.
  26. Cardoso, Ana. "MicroRNA modulation as a new therapeutic strategy for Alzheimer’s disease". Paper presented in XIV Meeting of Portuguese Society for Neurosciences, 2015.
  27. Cardoso, Ana. "Dissecting the role of microRNAs and their therapeutical potential in Alzheimer’s disease". Paper presented in 40th Congress of the Federation of the European Biochemical (FEBS) – The Biochemical Basis of Life, 2015.
  28. Cardoso, Ana. "MicroRNA modulation renders glioblastoma cells sensitive to chemotherapy". Paper presented in European Journal of Clinical Investigation (ESCI) 2015 Annual Scientific Meeting, 2015.
  29. Cardoso, Ana. "A promising targeted strategy to overcome drug-resistance in glioblastoma". Paper presented in EMBO workshop: Modern DNA concepts and tools for safe transfer and modification, 2015.
  30. Cardoso, Ana. "Dissecting the role of microRNAs and their therapeutic potential in Alzheimer’s disease". Paper presented in 12th International Conference on Alzheimer's and Parkinson's Diseases, 2015.
  31. Cardoso, Ana. "miR-21 and miR-128 modulation sensitizes glioblastoma cells to sunitinib treatment". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  32. Cardoso, Ana. "Vectorized oligonucleotide delivery renders glioblastoma cells sensitive to chemotherapy". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  33. Cardoso, Ana. "Molecular and phenotypic immune-related alterations in monocytes and monocyte-derived macrophages of Alzheimer’s disease Patients". Paper presented in 9th FENS Forum, 2014.
  34. Cardoso, Ana. "Molecular and phenotypic alterations in the mononuclear phagocyte system of Alzheimer’s disease patients". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  35. Cardoso, Ana. "Upregulation of c-Jun in the 3xTrg AD model regulates miR-155 expression in glial cells and contributes to neuroinflammation". Paper presented in European Meeting on Glial Cells in Health and Disease, 2013.
  36. Cardoso, Ana. "Silencing of miR-21 in microglia affects its immune response and enhances glioma cell death". Paper presented in EMBO's Young Scientist's Forum, 2013.
  37. Cardoso, Ana. "MiR-155 silencing decreases neuroinflammation in activated microglia and astrocytes". Paper presented in EMBO's Young Scientists Forum, 2013.
  38. Cardoso, Ana. "Deregulation of immune-related miRNAs in Alzheimer’s disease". Paper presented in 10th European meeting of glial cells in health and disease, 2011.
Journal article
  1. Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica; Laranjo, Mariana; Pinto, Maria J.; Reis, Tiago; Cardoso, Ana Maria; et al. "IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development". Neuron 111 21 (2023): 3435-3449.e8. http://dx.doi.org/10.1016/j.neuron.2023.09.031.
    10.1016/j.neuron.2023.09.031
  2. Martins, Mariana; Oliveira, Ana Rafaela; Martins, Solange; Vieira, José Pedro; Perdigão, Pedro; Fernandes, Ana Rita; de Almeida, Luís Pereira; et al. "A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectual Disability: Potential Implications on Neural Primary Cilia". International Journal of Molecular Sciences 24 16 (2023): 12603. http://dx.doi.org/10.3390/ijms241612603.
    Published • 10.3390/ijms241612603
  3. Oliveira, Fernanda Bellaniza Caminha de; Freire, Vanessa Paola Alves Sampaio de Sá; Coelho, Sharton Vinicius Antunes; Meuren, Lana Monteiro; Palmeira, Julys da Fonseca; Cardoso, Ana Luísa; Neves, Francisco de Assis Rocha; et al. "ZIKV Strains Elicit Different Inflammatory and Anti-Viral Responses in Microglia Cells". Viruses 15 6 (2023): 1250. http://dx.doi.org/10.3390/v15061250.
    Published • 10.3390/v15061250
  4. Regueira, Patrícia; Silva, Ana Rita; Cardoso, Ana Luísa; Cardoso, Ana Maria; Baldeiras, Inês; Santana, Isabel; Cerejeira, Joaquim. "Peripheral inflammatory markers during an acute bacterial infection in older patients with and without cognitive dysfunction: A case control study". Brain, Behavior, & Immunity - Health 25 (2022): 100503. http://dx.doi.org/10.1016/j.bbih.2022.100503.
    Published • 10.1016/j.bbih.2022.100503
  5. Silva, Ana Rita; Regueira, Patricia; Peres, André; Cardoso, Ana Luísa; Baldeiras, Inês; Santana, Isabel; Cerejeira, Joaquim. "In vivo molecular imaging of the neuroinflammatory response to peripheral acute bacterial infection in older patients with cognitive dysfunction: A cross-sectional controlled study". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.984178.
    Published • 10.3389/fnagi.2022.984178
  6. Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica M.; Cardoso, Ana L.; Peça, João. "Microglia-dependent remodeling of neuronal circuits". Journal of Neurochemistry 163 2 (2022): 74-93. http://dx.doi.org/10.1111/jnc.15689.
    Published • 10.1111/jnc.15689
  7. Oliveira, Ana Rafaela; Martins, Solange; Cammarata, Giuseppe; Martins, Mariana; Cardoso, Ana Maria; Almeida, Maria Rosário; do Carmo Macário, Maria; et al. "Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations". Biomedicines 10 8 (2022): 1905. http://dx.doi.org/10.3390/biomedicines10081905.
    Published • 10.3390/biomedicines10081905
  8. Costa Silva, Ana Rita; Regueira, Patrícia; Cardoso, Ana; Baldeiras, Ines; Santana, Isabel; Cerejeira, Joaquim. "Cognitive trajectories following acute infection in older patients with and without cognitive impairment: an one-year follow-up study". Frontiers in Psychiatry (2022):
    In press
  9. Jéssica Costa; Solange Martins; Pedro A. Ferreira; Ana M.S. Cardoso; Joana R. Guedes; João Peça; Ana L. Cardoso. "The old guard: Age-related changes in microglia and their consequences". Mechanisms of Ageing and Development 197 (2021): 111512-111512. https://doi.org/10.1016/j.mad.2021.111512.
    10.1016/j.mad.2021.111512
  10. Sequeira, Diana; Oliveira, Ana Rafaela; Seabra, Catarina M.; Palma, Paulo; Peça, João; Cardoso, Ana; Santos, João Miguel. "Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials". Clinical Oral Investigations (2021):
    Accepted
  11. Silva, Ana Rita; Regueira, Patrícia; Albuquerque, Elisabete; Baldeiras, Inês; Cardoso, Ana Luísa; Santana, Isabel; Cerejeira, Joaquim. "Estimates of Geriatric Delirium Frequency in Noncardiac Surgeries and Its Evaluation Across the Years: A Systematic Review and Meta-analysis". Journal of the American Medical Directors Association (2020): http://dx.doi.org/10.1016/j.jamda.2020.08.017.
    Published • 10.1016/j.jamda.2020.08.017
  12. Franco, Lara O.; Carvalho, Mário J.; Costa, Jéssica; Ferreira, Pedro A.; Guedes, Joana R.; Sousa, Renato; Cardoso, Ana L.; Peça, João. "Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling". Neuropsychopharmacology 45 9 (2020): 1438-1447. http://dx.doi.org/10.1038/s41386-020-0727-7.
    Published • 10.1038/s41386-020-0727-7
  13. Barros-Viegas, Ana Teresa; Guedes, Joana; Cardoso, Ana Maria; Pereira de Almeida, Luís; Resende de Oliveira, Catarina; Pedro de Magalhães, João; Peça, João; Cardoso, Ana Luísa. "miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease". Molecular Therapy - Nucleic Acids 19 (2020): 1219-1236. http://dx.doi.org/10.1016/j.omtn.2020.01.010.
    Published • 10.1016/j.omtn.2020.01.010
  14. Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Cardoso, Ana Luísa; Peça, João. "Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice". Nature Communications 10 1 (2019): http://dx.doi.org/10.1038/s41467-019-09382-9.
    10.1038/s41467-019-09382-9
  15. Sequeira, Diana; Seabra, Catarina; Palma, Paulo; Cardoso, Ana; Peça, João; Santos, João. "Effects of a New Bioceramic Material on Human Apical Papilla Cells". Journal of Functional Biomaterials 9 4 (2018): 74. http://dx.doi.org/10.3390/jfb9040074.
    10.3390/jfb9040074
  16. Cardoso, Ana Luisa; Fernandes, Adelaide; Aguilar-Pimentel, Juan Antonio; de Angelis, Martin Hrabe; Guedes, Joana Ribeiro; Brito, Maria Alexandra; Ortolano, Saida; et al. "Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases". Ageing Research Reviews 47 (2018): 214-277. http://dx.doi.org/10.1016/j.arr.2018.07.004 IF=8.973.
    10.1016/j.arr.2018.07.004
  17. Guedes, Joana R.; Lao, Taotao; Cardoso, Ana L.; El Khoury, Joseph. "Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-ß and Tau Pathologies". Frontiers in Neurology 9 (2018): http://dx.doi.org/10.3389/fneur.2018.00549 IF=3.508.
    10.3389/fneur.2018.00549
  18. Cabral Filho, P.E.; Cabrera, M.P.; Cardoso, A.L.C.; Santana, O.A.; Geraldes, C.F.G.C.; Santos, B.S.; Pedroso de Lima, M.C.; Pereira, G.A.L.; Fontes, A.. "Multimodal highly fluorescent-magnetic nanoplatform to target transferrin receptors in cancer cells". Biochimica et Biophysica Acta - General Subjects 1862 12 (2018): 2788-2796. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052949793&partnerID=MN8TOARS.
    10.1016/j.bbagen.2018.08.014
  19. Cunha, P.P.; Costa, P.M.; Morais, C.M.; Lopes, I.R.; Cardoso, A.M.; Cardoso, A.L.; Mano, M.; Jurado, A.S.; Pedroso De Lima, M.C.P.. "High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors". Human Molecular Genetics 26 22 (2017): 4375-4387. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034256071&partnerID=MN8TOARS.
    10.1093/hmg/ddx323
  20. Viegas, A.T.B.; Guedes, J.R.; Oliveira, A.R.; Cardoso, A.M.S.; Cardoso, A.L.C.. "miRNAs: New biomarkers and therapeutic targets in dementia". Current Pharmaceutical Design 23 5 (2017): 669-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017530528&partnerID=MN8TOARS.
    10.2174/1381612823666170111094702
  21. von Zglinicki, Thomas; Varela-Nieto, Isabel; Brites, Dora; Karagianni, Niki; Ortolano, Saida; Georgopoulos, Spiros; Cardoso, Ana Luisa; et al. "Frailty in mouse ageing: A conceptual approach". Mechanisms of Ageing and Development 160 (2016): 34-40. http://dx.doi.org/10.1016/j.mad.2016.07.004 IF=3.087.
    10.1016/j.mad.2016.07.004
  22. Cardoso, Ana L; Guedes, Joana R; de Lima, Maria C Pedroso. "Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions". Current Opinion in Pharmacology 26 (2016): 1-9. http://dx.doi.org/10.1016/j.coph.2015.09.001 IF=5.563.
    10.1016/j.coph.2015.09.001
  23. Guedes, Joana R.; Santana, Isabel; Cunha, Catarina; Duro, Diana; Almeida, Maria R.; Cardoso, Ana M.; de Lima, Maria C. Pedroso; Cardoso, Ana L.. "MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease". Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 3 (2016): 7-17. http://dx.doi.org/10.1016/j.dadm.2015.11.004.
    10.1016/j.dadm.2015.11.004
  24. Cabral Filho, P.E.; Cardoso, A.L.C.; Pereira, M.I.A.; Ramos, A.P.M.; Hallwas, F.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; et al. "CdTe quantum dots as fluorescent probes to study transferrin receptors in glioblastoma cells". Biochimica et Biophysica Acta - General Subjects 1860 1 (2016): 28-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946430431&partnerID=MN8TOARS.
    10.1016/j.bbagen.2015.09.021
  25. Costa, Pedro; Cardoso, Ana; Mano, Miguel; Lima, Maria. "MicroRNAs in Glioblastoma: Role in Pathogenesis and Opportunities for Targeted Therapies". CNS & Neurological Disorders - Drug Targets 14 2 (2015): 222-238. http://dx.doi.org/10.2174/1871527314666150116123610 IF=2.188.
    10.2174/1871527314666150116123610
  26. Costa, P.M.; Cardoso, A.L.; Mano, M.; de Lima, M.C.P.. "MicroRNAs in glioblastoma: Role in pathogenesis and opportunities for targeted therapies". CNS and Neurological Disorders - Drug Targets 14 2 (2015): 222-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930907378&partnerID=MN8TOARS.
  27. Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Cardoso, A.L.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S.. "Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression". Molecular Pharmaceutics 12 3 (2015): 716-730. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924023696&partnerID=MN8TOARS.
    10.1021/mp5005349
  28. Costa, P.M.; Cardoso, A.L.; Custódia, C.; Cunha, P.; Pereira De Almeida, L.; Pedroso De Lima, M.C.. "MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma". Journal of Controlled Release 207 (2015): 31-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926665383&partnerID=MN8TOARS.
    10.1016/j.jconrel.2015.04.002
  29. Guedes, J.R.; Custódia, C.M.; Silva, R.J.; de Almeida, L.P.; de Lima, M.C.P.; Cardoso, A.L.. "Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model". Human Molecular Genetics 23 23 (2014): 6286-6301. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926341070&partnerID=MN8TOARS.
    10.1093/hmg/ddu348
  30. Cardoso, A.M.; Calejo, M.T.; Morais, C.M.; Cardoso, A.L.; Cruz, R.; Zhu, K.; Pedroso De Lima, M.C.; Jurado, A.S.; Nyström, B.. "Application of thermoresponsive PNIPAAM-b-PAMPTMA diblock copolymers in siRNA delivery". Molecular Pharmaceutics 11 3 (2014): 819-827. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901742907&partnerID=MN8TOARS.
    10.1021/mp400510a
  31. Calejo, Maria Teresa; Cardoso, Ana Maria S.; Kjøniksen, Anna-Lena; Zhu, Kaizheng; Morais, Catarina M.; Sande, Sverre Arne; Cardoso, Ana Luísa; et al. "Temperature-responsive cationic block copolymers as nanocarriers for gene delivery". International Journal of Pharmaceutics 448 1 (2013): 105-114. http://dx.doi.org/10.1016/j.ijpharm.2013.03.028 IF=3.785.
    10.1016/j.ijpharm.2013.03.028
  32. Costa, Pedro M; Cardoso, Ana L; Mendonça, Liliana S; Serani, Angelo; Custódia, Carlos; Conceição, Mariana; Simões, Sérgio; et al. "Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment". Molecular Therapy - Nucleic Acids 2 (2013): e100. http://dx.doi.org/10.1038/mtna.2013.30 IF=6.425.
    10.1038/mtna.2013.30
  33. Guedes, J.; Cardoso, A. L. C.; Pedroso de Lima, M. C.. "Involvement of MicroRNA in Microglia-Mediated Immune Response". Clinical and Developmental Immunology 2013 (2013): 1-11. http://dx.doi.org/10.1155/2013/186872 IF=2.934.
    10.1155/2013/186872
  34. Trabulo, S.; Cardoso, A.L.; Cardoso, A.M.S.; Morais, C.M.; Jurado, A.S.; Pedroso de Lima, M.C.. "Cell-penetrating peptides as nucleic acid delivery systems: From biophysics to biological applications". Current Pharmaceutical Design 19 16 (2013): 2895-2923. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878655380&partnerID=MN8TOARS.
    10.2174/1381612811319160006
  35. Costa, P.M.; Cardoso, A.L.; Nóbrega, C.; Pereira de almeida, L.F.; Bruce, J.N.; Canoll, P.; Pedroso de Lima, M.C.. "MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma". Human Molecular Genetics 22 5 (2013): 904-918. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873438180&partnerID=MN8TOARS.
    10.1093/hmg/dds496
  36. Cardoso, A.M.; Trabulo, S.; Cardoso, A.L.; Maia, S.; Gomes, P.; Jurado, A.S.; Pedroso De Lima, M.C.. "Comparison of the efficiency of complexes based on S413-PV cell-penetrating peptides in plasmid DNA and siRNA delivery". Molecular Pharmaceutics 10 7 (2013): 2653-2666. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879735661&partnerID=MN8TOARS.
    10.1021/mp400078h
  37. Cardoso, Ana M.S.; Trabulo, Sara; Cardoso, Ana L.; Lorents, Annely; Morais, Catarina M.; Gomes, Paula; Nunes, Cláudia; et al. "S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization". Biochimica et Biophysica Acta (BBA) - Biomembranes 1818 3 (2012): 877-888. http://dx.doi.org/10.1016/j.bbamem.2011.12.022 IF=3.389.
    10.1016/j.bbamem.2011.12.022
  38. Costa, P.M.; Cardoso, A.L.; Pereira de almeida, L.F.; Bruce, J.N.; Canoll, P.; Pedroso de lima, M.C.. "PDGF-B-mediated downregulation of miR-21: New insights into PDGF signaling in glioblastoma". Human Molecular Genetics 21 23 (2012): 5118-5130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869025536&partnerID=MN8TOARS.
    10.1093/hmg/dds358
  39. Cardoso, Ana L.; Guedes, Joana R.; Pereira de Almeida, Luís; Pedroso de Lima, Maria C.. "miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production". Immunology 135 1 (2011): 73-88. http://dx.doi.org/10.1111/j.1365-2567.2011.03514.x IF=3.705.
    10.1111/j.1365-2567.2011.03514.x
  40. Trabulo, S.; Cardoso, A.M.; Santos-Ferreira, T.; Cardoso, A.L.; Simões, S.; Pedroso De Lima, M.C.. "Survivin silencing as a promising strategy to enhance the sensitivity of cancer cells to chemotherapeutic agents". Molecular Pharmaceutics 8 4 (2011): 1120-1131. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961082146&partnerID=MN8TOARS.
    10.1021/mp100426e
  41. Trabulo, Sara; Cardoso, Ana Luísa; Mano, Miguel; De Lima, Maria C. Pedroso. "Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems". Pharmaceuticals 3 4 (2010): 961-993. http://dx.doi.org/10.3390/ph3040961.
    10.3390/ph3040961
  42. Cardoso, A.L.C.; Costa, P.; de Almeida, L.P.; Simões, S.; Plesnila, N.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C.. "Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo". Journal of Controlled Release 142 3 (2010): 392-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-77349098528&partnerID=MN8TOARS.
    10.1016/j.jconrel.2009.11.004
  43. Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Plesnila, N.; Pedroso de Lima, M.C.; Wagner, E.; Culmsee, C.. "Tf-lipoplexes for neuronal siRNA delivery: A promising system to mediate gene silencing in the CNS". Journal of Controlled Release 132 2 (2008): 113-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-56349102126&partnerID=MN8TOARS.
    10.1016/j.jconrel.2008.08.014
  44. Trabulo, S.; Mano, M.; Faneca, H.; Cardoso, A.L.; Duarte, S.; Henriques, A.; Paiva, A.; et al. "S413-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA". Journal of Gene Medicine 10 11 (2008): 1210-1222. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149190435&partnerID=MN8TOARS.
    10.1002/jgm.1247
  45. Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Pelisek, J.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C.. "siRNA delivery by a transferrin-associated lipid-based vector: A non-viral strategy to mediate gene silencing". Journal of Gene Medicine 9 3 (2007): 170-183. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047102911&partnerID=MN8TOARS.
    10.1002/jgm.1006
  46. P. de Lima, M.; Girao da Cruz, M.; C. Cardoso, A.; Simoes, S.; de Almeida, L.. "Liposomal and Viral Vectors for Gene Therapy of the Central Nervous System". Current Drug Target -CNS & Neurological Disorders 4 4 (2005): 453-465. http://dx.doi.org/10.2174/1568007054546144 IF=3.236.
    10.2174/1568007054546144
  47. Teresa Girão da Cruz, M; Cardoso, A L C; de Almeida, L P; Simões, S; Pedroso de Lima, M C. "Tf-lipoplex-mediated NGF gene transfer to the CNS: neuronal protection and recovery in an excitotoxic model of brain injury". Gene Therapy 12 16 (2005): 1242-1252. http://dx.doi.org/10.1038/sj.gt.3302516 IF=5.18.
    10.1038/sj.gt.3302516
Thesis / Dissertation
  1. Cardoso, Ana. "Gene silencing as a promising strategy for neuroprotection : on the development of a lipid-based system for the delivery of siRNAs to he central nervous system". PhD, Universidade de Coimbra, 2008. http://hdl.handle.net/10316/7447.

Intellectual property

Provisional application for patent
  1. 2024. "Brain-cell specific partial cellular reprogramming treatment and prevention methods for Alzheimer’s disease and progeria, compositions therefore and uses thereof".
    Protected
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/04/03 Early-life IL-4 as a risk factor for Attention-Deficit/Hyperactivity Disorder. VIII Symposium Portuguese Glial Network
Glial Network (Braga, Portugal)
2023/05/03 Impact of early-life stress in neuroimmune interactions in the pre-frontal cortex: a tale of two sexes 7th Symposium of the Portuguese Glial Network
Glial Network (Albufeira, Portugal)
2022/12/07 How early-life adversity impacts neuronal connectivity and shapes circuit wiring in the pre-frontal cortex DCV Talks
DCV (Coimbra, Portugal)
2022/04/04 The influence of maternal bonding in neuroimmune synaptic sculpting 13º Symposium of Bial Foudation – Behind and Beyond the Brain; The mystery of time
Bial Foundation (Porto, Portugal)
2019/11/14 Regenerative Endodontics: in vivo model with Human Apical Papilla Cells 28º Congresso Ordem dos Médicos Dentistas
OMD (Lisboa)
2019/09/05 In vivo Regenerative Potential of Human Apical Papilla Cells Oral Health Conference
CED-IADR/NOF (Madrid, Spain)
2019/05/29 IL-4 skews the microglial developmental program during cerebellar maturation IV Symposium Portuguese Glial Network
Portuguese Glial Network (Lisbon, Portugal)
2018 Microglia morphology and density analysis: using stereology and 3D reconstruction to study the neuroimmune impact of early life stress 52º International Congress on Microscopy and Microanalysis
(Coimbra, Portugal)
2017 Immune alterations in progranulin mutation carriers have functional consequences in NCL: data from human NCL models”, 13th International Symposium of the Portuguese Society for Metabolic Disorders, March, Évora, Portugal 13th International Symposium of the Portuguese Society for Metabolic Disorders
(Évora, Portugal)
2016 MicroRNA contribution in a new therapeutic strategy for Alzheimer’s disease The 2016 Alzheimer’s Disease Congress
(Londres, United Kingdom)
2015 Lipid-based nanoparticles and their use in multimodal therapies towards glioblastoma VIII Congress of the National Association of Neurooncology
(Lisbon, Portugal)
2015 microRNAs and their therapeutical potential in Alzheimer's Disease ENCODS 2015 - European Neuroscience Conference by Doctoral Students for Doctoral Students
(Sesimbra, Portugal)
2015 The Role of miRNAs in neuroinflammation associated with Alzheimer’s disease 29º Encontro do Grupo de Estudos de Envelhecimento
(Aveiro, Portugal)
2015 Dissecting the role of microRNAs and their therapeutic potential in Alzheimer’s disease FEBS Young Scientists Forum
(Berlim, Germany)
2014 MicroRNAs and their therapeutic potential in Alzheimer’s disease World Forum of Young Scientists 2014
(Baku, Azerbaijan)
2013 Role of miR-21 in the regulation of microglia response to glioma 1st Research Coimbra
(Coimbra, Portugal)
2012 Efficient siRNA delivery mediated by S413-PV cell penetrating peptide-based systems: a comparative study 13th Naples Workshop on Bioactive Peptides. Conformation and activity in peptides: Relationships and Interactions
(Nápoles, Italy)
2012 MiR-155 silencing decreases neuroinflammation in Aß-stressed astrocytes and microglia cells 20th Congress of the European Society of Gene and Cell Therapy
(Versailles, France)
2011 PDGF-mediated modulation of miRNAs in glioblastoma multiforme: a new paradigm in miRNA regulation in brain tumors Portuguese Genetic Conferences
(Coimbra, Portugal)
2009 Lipoplex-mediated siRNA and DNA delivery to the CNS Nanomedicine Advanced Course, Molecular Medicine Institute
(Lisbon, Portugal)
2009 Folate receptor-targeting delivery of lipid-based systems aiming at cancer gene therapy GTRV- Summer School «Targeted Drug Delivery»
(Lausanne, Switzerland)
2008 S413-PV cell penetrating peptide associated with different cargos: assessment of delivery efficiency and internalization mechanisms 30th European Peptide Symposium (30EPS) - Cell-Penetrating Peptides Satellite Symposium
(Helsinki, Finland)
2006 Gene silencing in the CNS: Tf-lipoplexes for neuronal siRNA delivery in vitro and in vivo XV National Congress of Biochemistry
(Aveiro, Portugal)
2005 Cationic Liposome-mediated In Vivo Gene Transfer to the CNS XIV National Congress of Biochemistry
(Vilamoura, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/09/01 - Current Exploring the pathophysiological mechanisms and new lines of treatment for Frontotemporal Dementia, employing immunocompetent brain organoids
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/12/01 - Current Does early-life stress impact microglia-mediated remodeling of inhibitory circuits and myelination in the mPFC?
Supervisor
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016/09/01 - 2022/01/31 Regenerative Endodontics: in vivo model with Human Apical Papilla Cells
Co-supervisor
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra, Portugal
2019/09/01 - 2020/10/09 Dissecting the impact of early life stress in microglia: neuron dynamics in the medial prefrontal cortex
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2013 - 2019/10/18 On the persistence of therapy: The potential of miRNA modulation in Alzheimer’s disease
Supervisor
 Envelhecimento e Doenças Crónicas (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/09 - 2018/10 Long-term impact of early-life stress on adult social behaviour and pre-frontal cortical circuits
Co-supervisor
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/09 - 2018/06 The impact of early life stress throughout life: maternal separation-induced changes in behavior and microglia morphology
Supervisor
 Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09 - 2017/09 MiRNAs and risk gene interactions in Alzheimer's disease: from mechanisms to therapeutics
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/09 - 2016/09 Role of miR-29b in the regulation of progranulin and dna methyltransferases 3A and 3B expression : therapeutic potential in glioblastoma
Supervisor
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2016 Inflammation in Alzheimer's disease: deregulation and modulation of miRNA expression in the mononuclear phagocyte system
Supervisor
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013/09 - 2014/09 MiRNA Profilling and Modulation in Cancer Stem Cells isolated from Glioblastoma
Supervisor
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/09 - 2014/09 Effect of Bexarotene and Aß in microglia and macrophage TREM2 expression and M1/M2 polarization
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/09 - 2013/09 MiRNA contribution to APP metabolism and Aß production in Alzheimer’s disease: Identification of new miRNA-related SNPs in the 3’UTR of human APP and APOE genes
Supervisor
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/09 - 2013/07 Role of miR-21 in the regulation of microglia immune response to glioma
Supervisor
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/09 - 2013/07 The role of PDGF in the regulation of the intracellular pool of MMP-2: MMP-2 contribution to SNALP internalization in glioma cells
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/09 - 2011/07 Evaluation of miR-155 and miR-125b regulatory effect on astrocyte-mediated immune response
Supervisor
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/11/30 - 2021/11/30 V Symposium of the Portuguese Glial Network (2021/11/30 - 2021/11/30)
Symposium (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/10/14 - 2017/10/18 COST Action BM1402 training School – Principles of Drug Development, Novartis Campus, Switzerland (2017/10/14 - 2017/10/18)
Workshop (Co-organisor)
 Novartis International AG, Switzerland
2016/06/20 - 2016/06/23 Biological Markers in neurological diseases: present and future approaches” Advanced Course, JPND consortium BIOMARKAPD (2016/06/20 - 2016/06/23)
Workshop (Co-organisor)
 Hospitais da Universidade de Coimbra, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2015/09 - Current Researcher's Night
Exhibition
 Theater, Exhibition, Seminars
CNC.IBILI, Portugal
2015/03/01 - Current Brain Awareness Week
Other
 Visit to school
CNC.IBILI, Portugal
2021/04/21 - 2021/04/26 Web Seminars directed towards the general public and students concerning the importance of vaccination: Conversas com Cientistas - Décadas de Ciência para Dias de Vacinas
Conference
 Conversas com Cientistas - Décadas de Ciência para Dias de Vacinas
Ciência Viva, Portugal
2019/11/28 - 2019/11/28 Participation as invited speaker in the event “Café da Ciência – O Cérebro: Presente, Passado e Futuro”, Semana da Ciência e Tecnologia, 2019.
Conference
 Café da Ciência – O Cérebro: Presente, Passado e Futuro

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/03/25 Thioredoxin Reductase Inhibitors in anticancer therapy: Thimerosal Efficacy in Glioblastoma
(Thesis) Main arguer
 Isabella Calvo Bramatti (PhD)
Universidade de Lisboa, Portugal
2023/11/08 "Deciphering the glial and synaptic changes under chronic alcohol exposure using a self-administration paradigm.”
(Thesis) Arguer
 Ana Margarida Bravo rodrigues (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2023/09/25 Dissecting the mechanisms underlying the anti-inflammatory effects of sitagliptin on microglial cells.
(Thesis) Main arguer
 Cristiana Leote (Master)
Universidade de Coimbra Departamento de Física, Portugal
2023/09/20 “Duo therapeutic strategy: silencing ataxin-3 while co-expressing a homologous sequence”
(Thesis) Main arguer
 João Lourenço (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/02/15 The role of a candidate microRNA in mitochondrial dysfunction and inflammatory responses in vitro: relevance to Parkinson’s disease
(Thesis) Main arguer
 Beatriz da Silva Guedes (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2021/12/15 Assessing the role of the secretome of brain metastatic breast cancer cells in the phenotypic shift and oxidative response of microglia
(Thesis) Main arguer
 Ana Filipa Domingues Laranjeiro (Master)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/07/29 Influence of elevated hydrostatic pressure on Müller cells phenotype. Do microglia-derived microvesicles play a role?
(Thesis) Main arguer
 Magda Ferreira-Rodrigues (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/12/16 MICRORNA PROFILING IN HUMAN CELL-BASED MODELS OF MACHADO-JOSEPH DISEASE
(Thesis) Main arguer
 Maria Inês Nunes dos Santos (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020/07/29 Alloparental Behavior: the effect of pup exposure on nest building and the role of serotonin
(Thesis) Main arguer
 Catarina Pacheco (Master)
Universidade de Coimbra, Portugal
2018/07 Role of astrocytes in synaptic plasticity and memory in animal models of Alzheimer’s disease
(Thesis) Main arguer
 Cátia Sofia Resende Lopes (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/06 Biocompatibility of new endodontic sealers
(Thesis) Main arguer
 Joana Freitas (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017 Role of glial cells as contributors to the onset and propagation of ALS disease
(Thesis) Main arguer
 Joana Carolina Marinho Cunha (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/07 Dismorphic brain region regulation of microglia morphology and behavioural implication: focus on the crosstalk between glucocorticoids and A2A receptors
(Thesis) Main arguer
 Joana Filipa Mendes Duarte (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/07 miRNAs in the regulation of synaptic function
(Thesis) Main arguer
 Beatriz Figueiredo Rodrigues (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 Development of Monoolein-based lipofection vectors for therapeutic siRNA delivery
(Thesis) Main arguer
 Ana Cristina Norberto Gonçalves de Oliveira (PhD)
Universidade do Minho, Portugal
2016 Inflammation in Alzheimer's disease: deregulation and modulation of miRNA expression in the mononuclear phagocyte system
Supervisor
 Joana Ribeiro Guedes (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2015/07 GADD45ß: a novel long-term memory mediato
(Thesis) Main arguer
 David Vilhena Catarino Brito (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/09 Activity-dependent changes in the dendritic distribution of hnRNP K: functional implications
(Thesis) Main arguer
 Eduardo Firmino Morais (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/09 BDNF-induced local protein synthesis at the synapse: a regulatory role for hnRNuPK
(Thesis) Main arguer
 Luís Rodrigues (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/09 Role of AKT-regulated miRNAs in Non-small cell lung cancer
(Thesis) Main arguer
 Mafalda Raquel da Conceição Santos (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/09 Role of miRNAs and BDNF in the modulation of hippocampal neuron morphology and antidepressants
(Thesis) Main arguer
 Marta Costa Jordão (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Conference scientific committee

Conference name Conference host
2021/11/30 - 2021/11/30 V Symposium Portuguese Glial Network CNC - University of Coimbra

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/03/06 - Current Neuroimmunology Neuroimmunology (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2022/09 - Current Cellular Physiology Biology (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2018/02 - Current Neuronal Circuits - Master in Cellular and Molecular Biology Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/02 - Current “Neuroepigenetics” Advanced Course of the Doctoral Program in Biology and Experimental Medicine, 3rd Cycle Neuroepigenetics (Curso de doutoramento (conclusão de unidades curriculares)) CNC.IBILI, Portugal
2021/03/22 - 2021/03/26 Advanced Course - Synapse Structure and Function Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020/07/05 - 2020/07/09 Advances in Neuropharmaceutics Advances in Neuropharmaceutics (Pós-Graduação) Universidade de Lisboa Faculdade de Farmácia, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/08/06 Interview with Diário de Notícias concerning my career and recent work in the field of Dementia entitled: "O que é o microARN31 e como pode ser importante numa terapia para Alzheimer" Diário de Notícias
2021/06/06 Illustrated Chronicle in Journal Público in A Saúde no Saber - O que é a perturbação de hiperactividade e défice de atenção? Serão só bichos-carpinteiros? Público
2016/02/01 Estudo revela que falha de células imunitárias agrava doença de Alzheimer Expresso

Interview (tv / radio show)

Program Topic
2021/01/13 - Current 90s of Science miRNAs and Alzheimer's Disease
2022/03/24 - 2022/03/24 RUC - Semana Internacional do Cérebro Cerebral Immunity
2021/05/06 - 2021/05/06 Estudo em Casa - Sciences class directed at 9º grade students on the topic of the adolescent brain O cérebro Adolescente / The adolescent brain
2018/04/08 - 2018/04/08 MouseAGE ECR Case Study Early Career Researchers discuss the benefits of MouseAGE
Distinctions

Award

2019 Pfizer Award for Best Basic Research Publication of 2019
Pfizer AB, Sweden
2019 Honourable Mention in Basic Research

Other distinction

2004 Merit Fellowship
Universidade de Coimbra, Portugal