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Dina Maria da Silva Rodrigues Pereira finished her Applied Biology Degree in 2008 at the University of Minho - School of Sciences. In January 2020 completed her Doctoral degree in Experimental Biology and Biomedicine from the Institute of Interdisciplinary Research of University of Coimbra (IIIUC) at Center for Neuroscience and Cell Biology (CNC-UC). With over 10 years of research experience in neuroscience, viral vectors, disease models, biotechnology in health, ageing and oncobiology, contributed to many peer-reviewed publications. Currently, is a Junior Researcher at the University of Coimbra - Center for Neuroscience and Cell Biology (CNC-UC)/ CIBB - Center for Innovative Biomedicine and Biotechnology in the Gene and Stem Cell Therapies for the Brain Group.
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Identification

Personal identification

Full name
Dina Maria da Silva Rodrigues Pereira

Citation names

  • Pereira, Dina

Author identifiers

Ciência ID
6015-36DA-D03E
ORCID iD
0000-0002-6723-1159

Knowledge fields

  • Natural sciences - Biological Sciences - Biology
Education
Degree Classification
2020/01/09
Concluded
 Biologia Experimental e Biomedicina (Doutoramento)
Major in Biotecnologia e Saúde
Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
""The role of ageing in polyglutamine-induced neurodegeneration. A study in Machado-Joseph disease models"" (THESIS/DISSERTATION)
 Louvor e distinção por unanimidade
2008
Concluded
 Biologia Aplicada (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Human Leukocyte Antigen Class I expression and infection by JC virus in right-sided colon cancer" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2023/07/01 - Current Postdoc (Research) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2020/02/01 - 2023/06/30 Postdoc (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution 		Employer
2012/07/02 - 2012/09/30 Research trainee under the internal project: "Irradiation and atherosclerotic disease – epidemiologic and biologic evaluation of a cohort irradiated in childhood for tinea capitis treatment"- Cancer B Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2009/04/01 - 2012/06/30 Research trainee (FCT grant) under the project: (FCOMP-01-0124-FEDER-008463, former ref PIC/IC/83154/2007): “Cancer risk and irradiation: an epidemiological and genetic study of a cohort irradiated fo Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projects

Grant

Designation Funders
2022/11/01 - 2023/06/30 Fighting Sars-CoV-2 with viral vectors
CENTRO-01-01D2-FEDER000002
Post-doc Fellow
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Universidade de Coimbra
Concluded
2018/01 - 2018/12 JPCOFUND/0001/2015
JPCOFUND/0001/2015
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2017/01 - 2017/12/31 UID/NEU/04539/2013 - CNC. IBILI
UID/NEU/04539/2013
Research Fellow
CNC.IBILI, Portugal
Concluded
2012/10/01 - 2016/09/30 SFRH / BD / 51965 / 2012
SFRH / BD / 51965 / 2012
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2009/04/01 - 2012/06 FCOMP-01-0124-FEDER-008463, former ref PIC/IC/83154/2007
FCOMP-01-0124-FEDER-008463, former ref PIC/IC/83154/2007
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/07/01 - Current CiNTech - Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs
C644865576-00000005
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra
Ongoing

Other

Designation Funders
2020/02/01 - 2022/10 Calpain inhibition as a therapeutic strategy in Machado-Joseph disease
CPD0020A01
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Blade Therapeutics, Inc.
Concluded
2019/01/01 - 2020/01/31 Calpain inhibition as a therapeutic strategy in Machado-Joseph Disease
CPD0020A01
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Blade Therapeutics, Inc.
Concluded
Outputs

Publications

Book chapter
  1. Boaventura, Paula; Pereira, Dina; Soares, Paula; Teixeira-Gomes, José. "The ringworm campaign in Portugal, 1940–1970". In Ringworm and Irradiation, 181-214. Oxford University Press, 2022.
    10.1093/med/9780197568965.003.0007
  2. Nóbrega, Clévio; Simões, Ana Teresa; Duarte-Neves, Joana; Duarte, Sónia; Vasconcelos-Ferreira, Ana; Cunha-Santos, Janete; Pereira, Dina; et al. "Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis". In Advances in Experimental Medicine and Biology, 349-367. Springer International Publishing, 2018.
    10.1007/978-3-319-71779-1_18
  3. Boaventura, P; Pereira, Dina; Teixeira-Gomes,J; Soares, P. "Radiation Treatment and Alopecia – Past and Present Concerns". 1-22. Nova Science Publishers, 2012.
    Published
Conference abstract
  1. Arnaut, Zoe A.; Aroso, Rafael T.; Pinto, Sara M. A.; Lobo, Ana Catarina S. ; Amorim, Anita; Calvete, Mário J. F. ; Rodrigues-Santos, Paulo; et al. "Synthesis of di-imidazolyl porphyrins and their chlorin derivatives for photoinactivation of bacteria and viruses". Paper presented in XXVI Encontro Galego-Portugués de Química, 2022.
  2. Lobo, Diana; Nobre, Rui; Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Castelo-Branco, Miguel; De Almeida, Luís. "Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease: results from human and mouse samples". 2019.
    10.3389/conf.fncel.2019.01.00022
  3. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease". Paper presented in XLVIII Reunião Anual da Sociedade de Farmacologia, Lisbon, 2018.
  4. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebelar ataxia type-3 AND therapeutic success can be monitored by 1H-MRS". Paper presented in SPDMov 2018 Meeting ¿ ¿Genética nas Doenças do Movimento¿, 2018.
  5. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, TP; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease/spinocerebellar ataxia type-3, Human Gene Therapy". 2018.
    Published
  6. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, TP; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms. . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION". 2018.
    Published
Conference paper
  1. Ferreira-Marques, M; Cortes, Luisa; Valero, Jorge; Pereira, Dina; Almeida, Luís Pereira de; Cavadas, Cláudia; Aveleira, Célia A. Corresponding author: Aveleira, Célia A. "Human Progeria fibroblasts in culture to study new strategies to delay aging". Paper presented in JRC Summer School on Non-Animal Approaches in Science: The Three R...evolution, 2021.
    Published
Conference poster
  1. Núñez, Jisette; Pereira, Dina; Nobre, Rui Jorge; Pereira de Almeida, Luis. "Pseudotyped lentiviral particles with the SARS-CoV-2 S protein to study drug repurposing and immunological surveillance". Paper presented in Pharma PhD Day, 2023.
  2. Lopes, Sara Monteiro; Miguel M. Lopes; Nobre, Rui Jorge; Vasconcelos-Ferreira, Ana; Pereira, Dina; Fernandes, Ana Rita; Barros, Maria Inês; et al. Corresponding author: Pereira de Almeida, Luis. "Targeting the ATXN3 gene with CRISPR-Cas9 for the therapy of Machado-Joseph disease". Paper presented in 30th Annual Meeting of the European Society of Gene & Cell Therapy (ESGCT), Brussels, Belgium, 2023.
  3. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Pereira, Dina; Duarte, Sónia; Lopes, Sara Monteiro; Lopes, Miguel Monteiro; et al. "Investigating routes of administration and AAV serotypes for development of a gene-based therapy for spinocerebellar ataxia type 3 (SCA3)". Paper presented in ESGCT 30th Congress, 2023.
  4. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Fernandes, Ana Rita; Lopes, Miguel Monteiro; Pereira, Dina; Duarte, Sónia; et al. "Allele-specific silencing of mutant ATXN3 rescues motor deficits and neuropathology in a severely impaired mouse model of spinocerebellar ataxia type 3 (SCA3) upon intra-cisterna magna administration". Paper presented in ESGCT 30th Congress, 2023.
  5. Leandro, Kevin; Rufino-Ramos, David; Lopes, Sara Monteiro; Pasqua, C; Santos P; Silva, Ana Carolina; Lobo, Diana Duarte; et al. "Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems to treat Spinocerebellar Ataxia Type 3/Machado-Joseph Disease". Paper presented in CAG Triplet Repeat Disorders GRC, 2023.
  6. Rufino-Ramos, David; Leandro, Kevin; Vitor, Carmona; Martins, Ines Morgado; Albuquerque, Patrícia Rosado; Fernandes, Ana Rita; Henriques, Carina; et al. "Extracellular Vesicle-Based Delivery of Silencing Sequences for the Treatment of Machado-Joseph Disease". Paper presented in American Society of Gene Therapy (ASGCT) 26th Annual, 2023.
  7. Ribeiro, Rodrigo; Pereira, Dina; Reis, Tiago; Lopes, Sara; Ferreira-Marques, Marisa; Fernandes, Rita; Gaspar, Laetitia S; et al. "The Circadian Clock is Disrupted in the YAC Machado-Joseph Disease Mouse Model". Paper presented in BEB Day 2023 - Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) 17th symposium, 2023.
  8. Leandro, Kevin; Rufino-Ramos, David; D'Amelio, T.; Salgueiro, Margarida A.; Lopes, Sara M. ; Pereira, Dina; Martins, M. I.; et al. Corresponding author: Pereira de Almeida, Luis. "Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems to treat Machado-Joseph Disease". Paper presented in 29th Congress of the European Society for Gene and Cell Therapy (ESGCT) in collaboration with BSGCT; Edinburgh, Scotland, United Kingdom, 2022.
  9. Vasconcelos-Ferreira, Ana; Inês Morgado Martins; Lobo, Diana Duarte; Pereira, Dina; et al.. "Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph Disease". Paper presented in 2019 International Machado-Joseph Research Disease Conference. Washington, DC. USA, 2019.
  10. Silva, P.; Santana, Magda Matos; Cunha, Inês; Ribeiro, Joana; Pereira, Dina; Gaspar, Laetitia; Januário, Cristina; Pereira de Almeida, Luis. "Portuguese-mainland cohort of Machado-Joseph Disease: what can be seen after one-year follow-up?". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  11. Rui Jorge Nobre; Lobo, Diana Duarte; Catarina Oliveira Miranda; Pereira, Dina; Castelhano, Joao; Sereno, José Vitor Oliveira; Castelo-Branco, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Blood-brain barrier dysfunction in spinocerebellar ataxia type 3 (Machado-Joseph disease): Results from mouse and human brain tissues". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  12. Aveleira, Célia; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y enhances progerin clearance and delays cellular senescence in human Hutchinson-Gilford Progeria Syndrome cells.". Paper presented in 3rd Molecular Biology of Ageing Meeting, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, The Netherlands., 2019.
  13. Aveleira, Célia; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y ameliorates the aging phenotype of Hutchinson-Gilford Progeria Syndrome cells.". Paper presented in Ageing: models, mechanisms and therapies Conference, Faculty of Medicine, University of Coimbra, Coimbra, Portugal., 2019.
  14. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells ¿ and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers.". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
  15. Pereira, Dina; Janete Cunha-Santos; Ana Vasconcelos-Ferreira; Joana Duarte-Neves; Isabel Onofre; Vitor Carmona; Claudia Cavadas; Luís Pereira de Almeida. "The role of ageing in polyglutamine induced neurodegeneration. A Study in Machado-Joseph disease models". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, Lisbon, Portugal, 2019.
  16. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), 2018.
  17. Miranda, Catarina O.; Silva, Teresa P.; Marcelo, Adriana; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Paper presented in 1st international symposium Secretome With]Out[ Borders, 2018.
  18. Pereira, Dina; Janete Cunha-Santos; Joana Duarte-Neves; Ana Vasconcelos-Ferreira; Isabel Onofre; Claudia Cavadas; Luís Pereira de Almeida. "Is ageing the triggering factor in polyglutamine-induced neurodegeneration? A study in Machado-Joseph disease models". Paper presented in 2nd Molecular Biology of Ageing Meeting, Groningen, The Netherlands, 2017.
  19. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Pereira, Dina; Vasconcelos-Ferreira, Ana; Nóbrega, Clévio; et al. "Repeated treatment with Mesenchymal stromal cells sustainably alleviates Machado-Joseph disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons". Paper presented in 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2017.
  20. Pereira, Dina; Janete Cunha-Santos; Joana Duarte-Neves; Ana Vasconcelos-Ferreira; Isabel Onofre; Claudia Cavadas; Luís Pereira de Almeida. ""Is ageing the triggering factor in polyglutamine-induced neurodegeneration? A study in Machado-Joseph disease models". Paper presented in 1st Symposium on Aging Research @CNC – Molecular Mechanisms of Aging and Age-Related Diseases, Portugal, 2016.
  21. Aveleira, Célia; Botelho, Mariana; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y rescues the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells.". Paper presented in Cell Symposia ¿ Aging and Metabolism, Sitges, Spain., 2016.
  22. Aveleira, Célia; Cortes, Luísa; Ferreira-Marques, Marisa; Leal, Ana; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Ghrelin enhances progerin clearance and rescues the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells.". Paper presented in 8th Progeria Research Foundation International Scientific Workshop ¿ Across the Table, Around the Globe, Cambridge, MA, USA., 2016.
  23. Pereira, Dina; Janete Cunha-Santos; Joana Duarte-Neves; Ana Vasconcelos-Ferreira; Isabel Onofre; Claudia Cavadas; Luís Pereira de Almeida. "Is ageing the triggering factor in polyglutamine-induced neurodegeneration? A study in Machado-Joseph disease models". Paper presented in XIII CNC Annual Meeting, Portugal, 2015.
  24. Célia A. Aveleira; Luísa Cortes; Jorge Valero; Pereira, Dina; Luís Pereira de Almeida; Claudia Cavadas. "Neuropeptide Y enhances progerin clearance and rescues the senescent phenotype of human Hutchinson-Gilford progeria syndrome fibroblasts". Paper presented in The Translational Science of Aging: From Functional Pathways to Interventions Gordon Research Conference on Biology of Aging, Sunday River, Newry, USA, 2015.
  25. Magda M Santana; Nóbrega, Clévio David Rodrigues ; Nobre, Rui Jorge; Miranda, Catarina; Sousa-Ferreira, Ligia; Simões, Ana Teresa; Duarte, Sónia; et al. "Gene therapy approaches to investigate pathogenesis and disease modifying strategies for neurodegenerative diseases". Paper presented in Showcasing Portuguese Pharma Science:Advances in Discovery, Development and Manufacturing. Hovione and MIT Portugal Pharma Science Symposium, 2014.
  26. Boaventura, P.; Pereira, D.; Teixeira-Gomes, J.; Soares, P.. "1121 BRAF Mutations in Thyroid Carcinomas Following Childhood Scalp Irradiation". Paper presented in European Association for Cancer Research (EACR) 22th Meeting, 2012.
  27. Boaventura, Paula; Pereira, Dina; Oliveira, Rosa; Soares, Paula; Sobrinho-Simoes, Manuel; Teixeira-Gomes, José. "Thyroid lesions prevalence in individuals submitted to childhood X-ray epilation for tinea capitis treatment". Paper presented in 35th Annual Meeting of the European Thyroid Association (ETA 2011) Krakow, 2011.
  28. Boaventura, Paula; Pereira, Dina; Soares, Paula. "Estudo prospectivo e retrospectivo de lesões da cabeça e pescoço numa cohort irradiada na infância para o tratamento da tinea capitis". Paper presented in II Congresso Nacional de Saúde Pública, Portugal, 2010.
Journal article
  1. Arnaut, Zoe A.; Pinto, Sara M. A.; Aroso, Rafael T.; Amorim, Anita S.; Lobo, Catarina S.; Schaberle, Fabio A.; Pereira, Dina; et al. "Selective, broad-spectrum antiviral photodynamic disinfection with dicationic imidazolyl chlorin photosensitizers". Photochemical & Photobiological Sciences 22 11 (2023): 2607-2620. http://dx.doi.org/10.1007/s43630-023-00476-4.
    10.1007/s43630-023-00476-4
  2. Rufino-Ramos, David; Albuquerque, Patrícia R.; Leandro, Kevin; Carmona, Vitor; Martins, Inês M.; Fernandes, Rita; Henriques, Carina; et al. "Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3". Molecular Therapy 31 5 (2023): 1275-1292. http://dx.doi.org/10.1016/j.ymthe.2023.04.001.
    10.1016/j.ymthe.2023.04.001
  3. Santana, Magda M.; Gaspar, Laetitia S.; Pinto, Maria M.; Silva, Patrick; Adão, Diana; Pereira, Dina; Ribeiro, Joana Afonso; et al. "A standardized protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia". Neuropathology and Applied Neurobiology (2023): http://dx.doi.org/10.1111/nan.12892.
    10.1111/nan.12892
  4. Rodrigo F. N. Ribeiro; Dina Pereira; Luis Pereira de Almeida; Maria Manuel C. Silva; Cláudia Cavadas. "SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders". Aging Clinical and Experimental Research (2022): https://doi.org/10.1007/s40520-022-02257-y.
    10.1007/s40520-022-02257-y
  5. Lobo, Catarina S.; Rodrigues-Santos, Paulo; Pereira, Dina; Núñez, Jisette; Trêpa, João C. D.; Sousa, David Lopes; Lourenço, Jorge Vaz; et al. "Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulation". Photochemical & Photobiological Sciences (2022): http://dx.doi.org/10.1007/s43630-022-00202-6.
    10.1007/s43630-022-00202-6
  6. Ferreira-Marques, M; Carvalho, A; Franco, Ana Catarina; Leal, A; Botelho, M; Carmo-Silva, Sara; Águas, R; et al. Corresponding author: Aveleira, Célia A. "Enhancing ghrelin signaling alleviates aging and extends lifespan of a mouse model of human accelerated aging syndrome (under submission).". (2022):
    Submitted
  7. Ana Vasconcelos-Ferreira; Inês Morgado Martins; Diana Duarte Lobo; Pereira, Dina; Miguel M. Lopes; Rosário Faro; Sara M. Lopes; et al. "ULK overexpression mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease". Molecular Therapy (2021):
    Accepted
  8. Duarte Lobo, Diana; Nobre, Rui Jorge; Oliveira Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Koeppen, Arnulf; Castelo-Branco, Miguel; Pereira de Almeida, Luís. "The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples". Acta Neuropathologica Communications 8 1 (2020): http://dx.doi.org/10.1186/s40478-020-00955-0.
    10.1186/s40478-020-00955-0
  9. Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia. "Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells". The Journals of Gerontology: Series A 75 6 (2020): 1073-1078. http://dx.doi.org/10.1093/gerona/glz280.
    10.1093/gerona/glz280
  10. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, Teresa Pereira; Barata, Joao; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sonia; et al. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy". European Journal of Clinical Investigation (2019): https://publons.com/publon/28984639/.
  11. Oliveira Miranda, Catarina; Marcelo, Adriana; Silva, Teresa Pereira; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://dx.doi.org/10.1016/j.ymthe.2018.07.007.
    10.1016/j.ymthe.2018.07.007
  12. Boaventura, Paula; Pereira, Dina; Mendes, Adélia; Teixeira-Gomes, José; Sobrinho-Simões, Manuel; Soares, Paula. "Thyroid and parathyroid tumours in patients submitted to X-ray scalp epilation during the tinea capitis eradication campaign in the North of Portugal (1950–1963)". Virchows Archiv 465 4 (2014): 445-452. http://dx.doi.org/10.1007/s00428-014-1644-0.
    10.1007/s00428-014-1644-0
  13. Boaventura, Paula; Pereira, Dina; Mendes, Adélia; Batista, Rui; da Silva, André Ferreira; Guimarães, Isabel; Honavar, Mrinalini; et al. "Mitochondrial D310 D-Loop instability and histological subtypes in radiation-induced cutaneous basal cell carcinomas". Journal of Dermatological Science 73 1 (2014): 31-39. http://dx.doi.org/10.1016/j.jdermsci.2013.09.002.
  14. Boaventura, Paula; Pereira, Dina; Celestino, Ricardo; Mendes, Adélia; Nakasawa, Tadao; Teixeira-Gomes, José; Sobrinho-Simões, Manuel; Soares, Paula. "Genetic alterations in thyroid tumors from patients irradiated in childhood for tinea capitis treatment". European Journal of Endocrinology 169 5 (2013): 673-679. http://dx.doi.org/10.1530/eje-13-0543.
    10.1530/eje-13-0543
  15. Boaventura, Paula; Oliveira, Rosa; Pereira, Dina; Soares, Paula; Teixeira-Gomes, José. "Head and neck basal cell carcinoma prevalence in individuals submitted to childhood X-ray epilation for tinea capitis treatment". European Journal of Dermatology 22 2 (2012): 225-230. http://dx.doi.org/10.1684/ejd.2012.1670.
    10.1684/ejd.2012.1670
  16. Boaventura, P; Pereira, Dina; Soares, P; Teixeira-Gomes, P. "A campanha da tinha em Portugal – epidemia do passado e possíveis sequelas futuras". Publicação Oncológica Portuguesa Jan-Mar N5 (2012): 22-34.
    Published
  17. Boaventura, Paula; Soares, Paula; Pereira, Dina; Teixeira-Gomes, José; Sobrinho-Simões, Manuel. "Head and neck lesions in a cohort irradiated in childhood for tinea capitis treatment". The Lancet Infectious Diseases 11 3 (2011): 163-164. http://dx.doi.org/10.1016/s1473-3099(11)70047-0.
  18. Boaventura, P.; Bastos, J.; Pereira, D.; Soares, P.; Teixeira-Gomes, J.M.. "Alopecia in women submitted to childhood X-ray epilation for tinea capitis treatment". British Journal of Dermatology 163 3 (2010): 643-644. http://dx.doi.org/10.1111/j.1365-2133.2010.09846.x.
  19. de Miranda, Noel FCC; Nielsen, Maartje; Pereira, Dina; van Puijenbroek, Marjo; Vasen, Hans F; Hes, Frederik J; van Wezel, Tom; Morreau, Hans. "MUTYH-associated polyposis carcinomas frequently lose HLA class I expression-a common event amongst DNA-repair-deficient colorectal cancers". The Journal of Pathology 219 1 (2009): 69-76. http://dx.doi.org/10.1002/path.2569.
Preprint
  1. Dina Pereira; Janete Cunha-Santos; Ana Vasconcelos-Ferreira; Joana Duarte-Neves; Isabel Onofre; Vítor Carmona; Célia A Aveleira; et al. "Nuclear aging in polyglutamine-induced neurodegeneration". 2023. https://doi.org/10.1101/2023.06.09.544056.
    10.1101/2023.06.09.544056
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01 Targeted silencing via AAV9 polycistronic microRNA therapy rescues SCA3 molecular, neuropathological and motor deficits. 54 th Meeting of the Portuguese Society of Pharmacology, 42 nd Meeting of Clinical Pharmacology and 23 rd Meeting of Toxicology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2023/03 Let's make a puzzle: unravelling how Mesenchymal Stromal Cells decrease mutant ataxin-3 levels and promote ameliorations in Machado-Joseph Disease? DCV.talks - Departamento das Ciências e da Vida (DCV)
Departamento das Ciências e da Vida (DCV) (Coimbra, Portugal)
2023/02 Investigating the clock components and circadian activity in the YAC-MJD mouse model. 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2022/12 Mesenchymal Stem Cells for Brain Disorders: the Particular case of Machado-Joseph Disease. Seminar given inside the Gene and Cell Therapy Curricular Unit from the Biomedical Sciences Graduation
Biomedical Sciences Graduation - Algarve University (Portugal)
2022/02 Non-pathogenic viral vectors pseudotyped with the SARS-CoV-2 S protein to study drug repurposing and immunization strategies. 52ª Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2022 Engineered nucleases targeting the ATXN3 gene for the therapy of Machado-Joseph disease. Flash Talk Presentation. 27th European Society for Animal Cell Technology Meeting (ESACT2022)
European Society for Animal Cell Technology (Lisbon, Portugal)
2021/12 Non-pathogenic viral vectors pseudotyped with the SARS-CoV-2 S protein to study drug repurposing and immunization strategies. CIBB Annual Meeting
Centre for Innovative Biomedicine and Biotechnology (CIBB) (Coimbra, Portugal)
2021/06 Blood-brain barrier (BBB) disruption is a shared feature for several neurodegenerative diseases. 55TH ANNUAL SCIENTIFIC MEETING OF the European Society of Clinical Investigation (ESCI) – Online Event
European Society of Clinical Investigation (ESCI)
2021/02 Importin-8 Silencing Prevents Mutant Ataxin-3 Aggregation And Delays Machado-Joseph Disease Progression. 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2019/12 MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go? Center for Innovative Biomedicine and Biotechnology (CIIB) Meeting in Coimbra
Centre for Innovative Biomedicine and Biotechnology (CIBB) (Coimbra, Portugal)
2019/11 Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease. 2019 International Machado-Joseph Research Disease Conference. Washington, DC. USA
(Washington, DC, United States)
2019/11 Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease. International Research Ataxia Conference (IARC)
(Washington, DC, United States)
2019/11 Machado-Joseph Disease: the role of ageing in polyglutamine-induced neurodegeneration. 1st Annual Meeting in Pharmaceutical Sciences
Pharmacy Faculty of UC (Coimbra, Portugal)
2019/05 Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease: Results from mouse and human brain tissues. XVI Meeting of the Portuguese Society for Neuroscience (SPN2019)
Portuguese Society for Neuroscience (Lisbon, Portugal)
2019/05 Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells – and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers. XVI Meeting of the Portuguese Society for Neuroscience (SPN2019)
Portuguese Society for Neuroscience (Lisbon, Portugal)
2019/02 Disruption of Blood-Brain Barrier in Machado-Joseph Disease. XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia.
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019 Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease. 1st Annual Meeting in Pharmaceutical Sciences
Pharmacy Faculty of UC (Coimbra, Portugal)
2019 DISRUPTION OF BLOOD-BRAIN BARRIER IN MACHADO-JOSEPH DISEASE. XLIX Reunião da Sociedade portuguesa de Farmacologia; XXXVII Reunião de Farmacologia Clínica; XVIII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2018/07 Neuropeptide Y rescues aging phenotype of human Hutchinson-Gilford Progeria syndrome fibroblasts. 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
(Kyoto, Japan)
2018/02 "The role of ageing in polyglutamine-induced neurodegeneration. A Study in Machado-Joseph disease models" XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2018/02 "Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease" XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2017/02 "Is ageing the triggering factor in polyglutamine-induced neurodegeneration? A study in Machado-Joseph disease models" XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Ghrelin ameliorates the senescent phenotype of human Hutchinson-Gilford progeria syndrome cells. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/01 Is ageing the triggering factor in polyglutamine-induced neurodegeneration? A study in Machado-Joseph disease models. BEB DAY - Not So Usual Insights Into a PhD
Center for Neuroscience and Cell Biology (CNC), University of Coimbra (Coimbra, Portugal)
2016 NPY reverts HGPS phenotype. 8th Progeria Research Foundation International Scientific Workshop ¿ Across the Table, Around the Globe, Cambridge, MA, USA.
Progeria Research Foundation (Cambridge, MA, United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022 - Current Jisette Nuñez - Título da tese : Drug repurposing, immunological surveillance, and vaccine development for COVID-19 - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2022.12572.BD Orientadores: Luís Pereira de Almeida e Dina Pereira
Co-supervisor
2020/09/21 - 2021/11/19 Non-pathogenic viral vectors of SARS-CoV-2 to study drug repurposing and immunization strategies
Supervisor
 Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2014 - 2014 Member of the Organizing Committee for the CNC Annual Meeting, University of Coimbra (2014 - 2014)
Conference (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2013 Member of the Organizing Committee for the 2nd BEB Symposium (2013 - 2013)
Symposium (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 - 2007 Member of the Organizing Committee for the Annual Applied Biology Conferences “IX Jornadas de Biologia Aplicada" (2007 - 2007)
Conference
 Universidade do Minho, Portugal
Distinctions

Other distinction

2011 2ª edição do prémio ACS-Merck Serono – Epidemiologia do Cancro