Patrícia Ribeiro Leal da Silva Dinis (6018-BA30-7ED0)

Curriculum Vitae

Patrícia Ribeiro Leal da Silva Dinis

My training and research background is on cellular and molecular biology, and biotechnological engineering. My career has been developed at the Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, within the framework of several fields of Veterinary Medicine, specifically in the area of Reproductive and Developmental Biology. Moreover, I'm particularly focused on the 1) Molecular mechanisms that regulate sperm function; 2) Molecular basis of the crosstalk between gamete/embryo and female reproductive tract and 3) Host-pathogen interactions during the course of the uterine disease (canine pyometra and bovine endometritis). In parallel, I'm also involved in the veterinary molecular diagnosis of external services (diagnosis of bovine respiratory/reproductive diseases; Faculty of Veterinary Medicine, University of Lisbon - LabRepA; http://www.fmv.ulisboa.pt/pt/servicos/diagnostico/laboratorio-de-reproducao-animal).

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Identification

Personal identification

Full name: Patrícia Ribeiro Leal da Silva Dinis

Citation names

Diniz, Patrícia
Diniz, P

Author identifiers

Ciência ID: 6018-BA30-7ED0
ORCID iD: 0000-0001-5303-6953

Email addresses

pdiniz@fmv.ulisboa.pt (Professional)

Telephones

Telephone

213602049 (Professional)

Addresses

Faculdade de Medicina Veterinária. Reprodução e Obstetrícia, Av da Universidade Técnica, Polo Univ.-Alto da Ajuda, 1300-477, Lisboa, Lisboa, Portugal (Professional)

Websites

http://ciisa.fmv.ulisboa.pt/en/research-labs/reproduction-and-development/pessoas/item/257-rl8-patricia (Professional)

Knowledge fields

Agrarian Sciences - Veterinary Sciences
Natural sciences - Biological Sciences
Natural sciences - Biological Sciences - Reproductive Biology
Natural sciences - Biological Sciences - Molecular Biology
Natural sciences - Biological Sciences - Microbiology
Natural sciences - Biological Sciences - Biochemistry
Natural sciences - Biological Sciences - Biochemical Research Methods

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
Spanish; Castilian	Elementary (A2)	Elementary (A2)	Beginner (A1)	Intermediate (B1)	Elementary (A2)
French	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2017/10 - 2022 Ongoing	Veterinary Sciences (Doutoramento) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal "Understanding the role of NOTCH signaling components in sperm function" (THESIS/DISSERTATION)
2017 Concluded	MSc in Biotechnology Engineering (Master) Universidade Lusófona de Humanidades e Tecnologias, Portugal "Aspects of the Pathogenesis of Pyometra in the Dog: Escherichia coli Type 1 Fimbriae and Defense Mechanisms in the Endometrium" (THESIS/DISSERTATION)	18
2012 Concluded	Biotechnology Engineering (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal "n/a" (THESIS/DISSERTATION)	13 valores
1995 Concluded	Biotechnology (Bachelor) Universidade Lusófona de Humanidades e Tecnologias, Portugal "Biotecnologia" (THESIS/DISSERTATION)	13 valores

Affiliation

Science

	Category Host institution	Employer
2000/01/01 - Current	Research Assistant (Research)	Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
	Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Other Careers

	Category Host institution	Employer
2020/03/01 - Current	Técnico Superior (Técnico Superior)	Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

2000/01/03 - 2017/09/30	Técnico Superior (Técnico Superior)	Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Others

	Category Host institution	Employer
2017/10/01 - Current	PhD Student	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal (...)
2014/07/01 - Current	Involved in the molecular diagnosis external services:	Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

1997/09/01 - 1999/09/01	Scholarship PRAXIS BTI 4318/96	Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Projects

Contract

	Designation	Funders
2017 - Current	Innovative Biotechnological Solutions for the Control of Bovine Genital Campylobacteriosis FCT-02/SAICT/2017 (30145) Researcher Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal	Concluded
2023 - 2025	Epigenetics Modifications in Mare Endometrium: Implications on endometriosis and fibrosis pathogenesis 2022.09161 PTDC	Ongoing
2022 - 2023	Role of Notch and Wnt signaling during pre-implation development on subsequente fetal growth EXPL/CVT-CVT/1173/2021 Researcher Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
2021 - 2023	Exploring resolving mechanisms in cow persistent uterine and mammary inflammation PTDC/CVT-CVT/6932/2020 Researcher Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal	Concluded
2014 - 2018	How to solve infertility: is fighting neutrophil extracellular traps, cytokines or prostaglandins a solution? PTDC/CVT-REP/4202/2014 Researcher Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal	Concluded
2014/03/14 - 2015/09/13	Notch-wnt signaling cross-talk in the regulation of pre-implantation embryo development. EXPL/CVT-REP/2289/2013 Researcher Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2011	The NOTCH-DELTA Signaling Pathway in the Reproductive Function of the Mouse and Cow PTDC/CVT/105022/2008 Researcher Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal	Concluded
2006 - 2009	Relationships embryo-uterus-ovary determining embryonic and foetal survival in cattle. PTDC/CVT/65690/2006 Researcher Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal	Concluded
2005/02/01 - 2008/01/31	Use of transgenic conditional overexpession to address the function of a novel mammalian Delta homologue, mDll4, POCTI/CVT/48766/2002 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2005/02/01 - 2008	Role of prostaglandins and endotoxins on the establishment and persistence of puerperal endometritis in dairy cows info:eu-repo/grantAgreement/FCT/POCI/48773/PT Researcher	Concluded
2004 - 2007	Arteriogenesis: indentification of new members of the Notch pathway involved in arterial cell fate determination. POCI/CVT/56015/2004 Researcher Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal	Concluded
2002 - 2005	Role of prostaglandins and endotoxins on the establishment and persistence of puerperal endometritis in dairy cows POCTI/CVT/48773/2002 Researcher Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal	Concluded

Outputs

Publications

Journal article

Patrícia Diniz; Inês Leites; Mariana R. Batista; Ana Catarina Torres; Luísa Mateus; Luís Lopes-da-Costa; Elisabete Silva. "Characterization of expression patterns and dynamic relocation of Notch proteins during acrosome reaction of bull spermatozoa". Scientific Reports (2024): http://dx.doi.org/10.1038/s41598-024-65950-0.
10.1038/s41598-024-65950-0
Ferreira, Ana Filipa; Machado-Simões, Juliana; Moniz, Inês; Soares, Maria; Carvalho, Alexandra; Diniz, Patrícia; Ramalho-Santos, João; et al. "Chemical reversion of age-related oocyte dysfunction fails to enhance embryo development in a bovine model of postovulatory aging". Journal of Assisted Reproduction and Genetics 41 8 (2024): 1997-2009. https://doi.org/10.1007/s10815-024-03151-4.
10.1007/s10815-024-03151-4
Batista, Mariana R; Diniz, Patrícia; Murta, Daniel; Torres, Ana; Lopes-da-Costa, Luís; Silva, Elisabete. "Balanced Notch-Wnt signaling interplay is required for mouse embryo and fetal development". Reproduction (2021): http://dx.doi.org/10.1530/rep-20-0435.
Published • 10.1530/rep-20-0435
BatistaM, Diniz P, Torres A, Murta D, Lopes-da-Costa L,. "Notch signaling in mouse blastocyst development and hatching". BMC Developmental Biology (2020):
Open access
Henriques, Sofia; Silva, Elisabete; Silva, Marta F.; Carvalho, Sandra; Diniz, Patrícia; Lopes-da-Costa, Luís; Mateus, Luisa. "Immunomodulation in the canine endometrium by uteropathogenic Escherichia coli". Veterinary Research 47 1 (2016): http://dx.doi.org/10.1186/s13567-016-0396-z.
10.1186/s13567-016-0396-z
Torres, A.; Batista, M.; Diniz, P.; Silva, E.; Mateus, L.; Lopes-Da-Costa, L.. "Effects of oocyte donor age and embryonic stage of development on transcription of genes coding for enzymes of the prostaglandins and progesterone synthesis pathways in bovine in vitro produced embryos". Zygote 23 6 (2015): 802-812. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945458986&partnerID=MN8TOARS.
10.1017/S0967199414000446
Torres, A.C.; Boruszewska, D.; Batista, M.; Kowalczyk-Zieba, I.; Diniz, P.; Sinderewicz, E.; Saulnier-Blache, J.S.; Woclawek-Potocka, I.; Lopes-Da-Costa, L.. "Lysophosphatidic acid signaling in late cleavage and blastocyst stage bovine embryos". Mediators of Inflammation 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899919478&partnerID=MN8TOARS.
10.1155/2014/678968
Boruszewska, D.; Torres, A.C.; Kowalczyk-Zieba, I.; Diniz, P.; Batista, M.; Lopes-Da-Costa, L.; Woclawek-Potocka, I.. "The effect of lysophosphatidic acid during in vitro maturation of bovine oocytes: Embryonic development and mRNA abundances of genes involved in apoptosis and oocyte competence". Mediators of Inflammation 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84896905011&partnerID=MN8TOARS.
10.1155/2014/670670
Torres, A.; Batista, M.; Diniz, P.; Mateus, L.; Lopes-Da-Costa, L.. "Embryo-luteal cells co-culture: An in vitro model to evaluate steroidogenic and prostanoid bovine early embryo-maternal interactions". In Vitro Cellular and Developmental Biology - Animal 49 2 (2013): 134-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879503041&partnerID=MN8TOARS.
10.1007/s11626-012-9577-x
Torres, A.; Chagas E Silva, J.; Diniz, P.; Lopes-Da-Costa, L.. "Evaluation of treatments with hCG and carprofen at embryo transfer in a demi-embryo and recipient virgin heifer model". Animal 7 8 (2013): 1317-1322. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880204756&partnerID=MN8TOARS.
10.1017/S1751731113000426
Batista, M.; Torres, A.; Diniz, P.; Mateus, L.; Lopes-da-Costa, L.. "Development of a bovine luteal cell in vitro culture system suitable for co-culture with early embryos". In Vitro Cellular and Developmental Biology - Animal 48 9 (2012): 583-592. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872009575&partnerID=MN8TOARS.
10.1007/s11626-012-9552-6
Chagas e Silva, J.; Diniz, P.; Lopes da Costa, L.. "Luteotrophic effect, growth and survival of whole versus half embryos and, their relationship with plasma progesterone concentrations of recipient dairy heifers". Animal Reproduction Science 104 1 (2008): 18-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549000999&partnerID=MN8TOARS.
10.1016/j.anireprosci.2007.01.004
Duarte, A.; Hirashima, M.; Benedito, R.; Trindade, A.; Diniz, P.; Bekman, E.; Costa, L.; Henrique, D.; Rossant, J.. "Dosage-sensitive requirement for mouse Dll4 in artery development". Genes and Development 18 20 (2004): 2474-2478. http://www.scopus.com/inward/record.url?eid=2-s2.0-5444261424&partnerID=MN8TOARS.
10.1101/gad.1239004
Mateus, L.; Lopes da Costa, L.; Diniz, P.; Ziecik, A.J.. "Relationship between endotoxin and prostaglandin (PGE2 and PGFM) concentrations and ovarian function in dairy cows with puerperal endometritis". Animal Reproduction Science 76 3-4 (2003): 143-154. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037445808&partnerID=MN8TOARS.
10.1016/S0378-4320(02)00248-8

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2016/10/27	Notch and Wnt interplay in the regulation of the pace of embryo developmental kinetics. Reprod Dom Anim. 51(S2).	Animal Reproduction (ESDAR) and the 13th Conference of the Spanish Association for Animal Reproduction (AERA)

Event participation

	Activity description Type of event	Event name Institution / Organization
2014 - Current	Poster presentation: Diniz P., Mateus L., Henrique S., Lopes-da-Costa L., Silva E. (2014). Analysis of the phase variation of type 1 fimbrial genes in canine pyometra Escherichia coli isolates. Congress	VI Congress of the Portuguese Society of Veterinary Science Instituto Nacional de Investigação Agrária e Veterinária, Portugal
2014 - Current	Poster presentation: Torres A., Batista M., Diniz P., Silva E., Mateus L., Lopes-da-Costa L. (2014). Transcription of genes coding for enzymes of the prostaglandins and progesterone synthesis pathways in bovine in vitro-produced embryos is affected by donor age and embryonic stage of development. Congress	VI Congress of the Portuguese Society of Veterinary Science, Instituto Nacional de Investigação Agrária e Veterinária, Portugal
2012 - Current	Course on Laboratory Animal Science, (100h), FMV-UTL in collaboration with the University of Utrecht (FELASA C level), 2012 Other	Course on Laboratory Animal Science, (100h), FMV-UTL in collaboration with the University of Utrecht (FELASA C level), 2012 Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2004 - Current	Poster presentation: Trindade A., Benedito R., Diniz P., Costa L., Henrique D., Duarte A.. (2004). mDll4 overexpression causes arterial hypertrophy and loss of venous identity in developing mouse embryos. Congress	XXXI Jornadas da Portuguesas de Genética Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2003 - Current	Poster Presentation: Trindade A., Benedito R., Diniz P., Costa L., Henrique D., Duarte A.. (2003). mDll4 overexpression causes arterial hypertrophy and loss of vascular identity in developing mouse embryos. Conference	Gordon Conference.
2019/06/01 - 2019/06/06	Image acquisition course applied to the study of reproduction - Precision 2d Multi-scale Imaging for the Study of Reproduction”. INRA, Nouzilly – France Workshop	Precision 2d Multi-scale Imaging for the Study of Reproduction”
2018/09/27 - 2018/09/29	Poster presentation: Diniz P., Batista M., Mateus L., Lopes-da-Costa L., Silva, E. (2018). Dynamic remodeling of Notch signaling proteins in bovine spermatozoa during the acrosome reaction. Congress	22nd Annual ESDAR Conference
2017/12/07 - 2017/12/09	Poster presentation: Silva E., Lourenço B., Semedo-Lemsaddek T., Carneiro C., Silva M.F., Diniz P., Lopes-Da-Costa, L., Mateus, L. (2017). Within-household sharing of fecal and vaginal Escherichia coli between healthy female dogs. Congress	MICROBIOTEC17; Congress of Microbiology and Biotechnology.
2016/10/27 - 2016/10/29	Poster presentation: Diniz P., Batista M., Murta D., Torres A.C., Mateus L., Lopes-da-Costa L., Silva E. (2016). Notch expression in bovine spermatozoa. Congress	20th Annual ESDAR conference. European Society for Animal Reproduction
2016/06/22 - 2016/06/25	Poster presentation: Henriques S., Silva M.F, Diniz P., Lopes-da-Costa L., Silva E, Mateus L.. (2016). Effect of hemolytic and non-hemolytic E. coli on canine endometrial epithelial and stromal cells. Congress	Proceedings of the 8th International Symposium on Canine and Feline Reproduction with XIX EVSSAR Congress
2012/10/01 - 2012/10/03	Poster presentation: Woclawek-Potocka I., Torres A., Kowalczyk-Zieba I., Diniz P., Raposo M., Blache J.S.S., Skarzynski D.J., Lopes da Costa L.. (2012). The bovine embryo – Source and target of lysophosphatidic acid in the cow. Congress	Proceedings of the 3rd General Meeting of GEMINI
2012/06/03 - 2012/06/08	Poster presentation: Barros Luís, Diniz Patrícia, Mateus Luísa, Lopes da Costa Luís. (2012). Effects of calving related diseases on reproductive parameters of high-yielding dairy cows. XXVII Congresso Mundial de Buiatria, 3 a 8 de Jun. Lisboa, Portugal, pp.201. Congress	XXVII Congresso Mundial de Buiatria
2012/05/16 - 2012/05/17	Poster presentation: Boruszewska D., Torres A.C., Kowalczyk-Zieba I., Diniz P., Raposo M., Skarzynski D.J., Lopes da Costa L., Woclawek-Potocka I.. (2012). The effect of lysophosphatidic acid on bovine embryo culture- in vitro study. Symposium	IX SYMPOSIUM: "Genetic, physiological and environmental conditions of animal reproduction and health as well as safety and quality of animal origin food."
2009/10/01 - 2009/10/03	Poster presentation: Batista M.R., Torres A.C., Diniz P., Mateus L., Lopes da Costa L.. (2009). Performance of luteal cells in an in vitro culture system designed for bovine in vitro embryo production. Congress	Proceedings of the 2nd General Meeting of GEMINI
2002/10/10 - 2002/10/12	Poster Presentation: Freitas Duarte A., Diniz P., Pimenta J., Benedito R., Trindade A., Matos M., Rodriguez, T., Henrique D., Lopes da Costa, L. (2002). Caracterização de um novo gene Delta (mDelta4) com expressão endotelial por técnicas de transgénese em mamíferos. Proc. do Congresso de Ciências Veterinárias, Oeiras, Portugal, 10-12 Out. pp. 453. Congress	Proc. do Congresso de Ciências Veterinárias
2001/05/24 - 2001/05/25	Poster Presentation: Freitas Duarte, A., Pimenta J., Diniz P., Henrique, D., Lopes da Costa, L. (2001). Cloning and Characterization of a novel mammalian Delta homologue, mDELTA-4. Proc. 1º Simposium Internacional do CIISA, Lisboa, Portugal, 24-25 Mai. pp 83. Symposium	Proc. 1º Simposium Internacional do CIISA Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal