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Carmen Diniz (August, 1968, Canada) holds a PhD in Pharmacology (2003) from the University of Porto-Faculty of Pharmacy, a MSc in Human Biology (1997) from the University of Porto-Faculty of Medicine, and a degree in Pharmaceutical Sciences (1992) from the University of Coimbra-Faculty of Pharmacy. C. Diniz is currently an Assistant Professor at the Department of Drug Sciences of the University of Porto (Portugal) and Integrated Researcher at REQUIMTE LAQV Porto. She has supported several national and international research projects and postgraduate trainings (PDFTEC and DEMSSO of U.Porto and of Doctorado Farmacologia y Fisiologia of Universidad Autonoma de Madrid) in the Pharmacology field (14 PhD, 6 MSc, 1 PosDoc). She has authored 72 scientific publications, 8 book chapters and edited 1 book (H-index=16, ca. 1140 citations) and has co-organized 6 international and national scientific events. She has been involved as a researcher in 28 projects and as principal investigator in 4 projects. In her professional activities, she interacted with 181 co-authors of scientific works. C. Diniz is a reviewer for several international journals in the field of pharmacology, image analysis, cardiometabolic diseases and cancer and a member of several international committees for the evaluation of scientific research projects (MRC-France, CNCS-Romenia, OTKA-Hungary). C. Diniz holds a FELASA C certificate and is accredited by the Direção Geral de Alimentação e Veterinária (DGAV, Portugal) to work with laboratory animals, including animal models of disease. Her current research interests are in medical biotechnology research using cell, tissue and organ-based assays, with a focus on drugs, food and health: Effects of drugs and foods on proteins/enzymes and receptors and their utility in physiology and pathophysiology, namely in cancer (treatment and prevention), inflammation, oxidative stress, endothelial dysfunction and angiogenesis, hypertension and fetal programming. An important part of my work has been dedicated to the implementation of methodologies that allow the study of cell signaling pathways (alphascreen methodology combined with qPCR and immunohistochemistry/Western blot) and image analysis in animal tissues and in cell culture models (primary and immortalized). C. Diniz currently maintains national and international scientific collaborations, namely with the University Autonoma de Madrid (Spain), Universidade de São Paulo (Brazil), University of Kosice (Eslováquia), Universidade de Aveiro (Portugal), Universidade de Coimbra (Portugal), and in her curriculum the most frequent terms related to scientific results are Cancer cells; in vivo; oxidative stress; adenosine; proliferation, invasion, image analysis, oncology, noradrenaline, GPCR, metal-based chemotherapeutics.
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Identification

Personal identification

Full name
Carmen Diniz Pereira

Author identifiers

Ciência ID
601A-38A8-811A
ORCID iD
0000-0003-4668-9360
Google Scholar ID
https://scholar.google.com/citations?view_op=list_works&hl=pt-PT&user=UeQtCD0AAAAJ
Researcher Id
D-6293-2013
Scopus Author Id
7006548490

Websites

Education
Degree Classification
2013/06/17
Concluded
 Creditado como Investigador Coordenador para a prática de experimentação animal (Título de Habilitação de Coordenação Científica)
Direcção-Geral de Alimentação e Veterinária, Portugal
2003
Concluded
 Farmacologia (Doutoramento)
Major in Sem especialidade
Universidade do Porto Faculdade de Farmácia, Portugal
"Variabilidade na Modulação Exercida pela Adenosina na Transmissão Simpática Pós-ganglionar em Tecidos com Cotransmissão Noradrenalina/atp" (THESIS/DISSERTATION)
1997/11/13
Concluded
 Biologia Humana (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
"Libertação da taurina induzida por estimulação eléctrica do canal deferente de Rato: causas e possíveis mecanismos de libertação" (THESIS/DISSERTATION)
1992
Concluded
 Ciências Farmacêuticas (Mestrado integrado)
Major in Farmácia de Oficina e Hospitalar
Universidade de Coimbra Faculdade de Farmácia, Portugal
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2003/03/29 - Current Assistant Professor (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal
1997/11 - 2003/03 Assistant (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal
1997 - 1997 Trainee Assistant (University Teacher) Universidade do Porto, Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
1993 - 1996/09 Empresa de produtos de equipamentos e produtos de laboratório ELNOR SA, Portugal
1992 - 1993 Farmácia Farmácia Falcão, Portugal
Projects

Grant

Designation Funders
2023/11/01 - Current Blackcurrant anthocyanins: A promising dietary strategy as chemopreventive and chemotherapy adjuvant for triple negative breast cancer?
2023.05253.BD
Supervisor
Ongoing
2020 - Current Recovery of peptides from brewing by-products to control hypertension
SFRH/BD/146243/2019
Supervisor
Universidade do Porto, Faculdade de Farmácia, Portugal
Ongoing
2017/01 - 2023 Biochemical Impact of Platinum and Palladium-based Anticancer Agents
PD/BD/135460/2017
Supervisor
REQUIMTE LAQV Porto, Portugal
 N/A
Concluded
2009/09/01 - 2014/11 Role of Adenosine Receptors In Vascular Responsiveness: Influence of ROS Levels and NO-Mediated Effects, And Its Relation With Hypertension
SFRH/BD/63420/2009
Supervisor
Concluded
2009/09/01 - 2014/06 The Role of Adenosine Receptor Subtypes In Human Melanoma: In Vitro And In Vivo Studies
SFRH/BD/64911/2009
Supervisor
Concluded
2006/09/01 - 2013/01 Papel potencial dos receptores de adenosina vasculares no desenvolvimento/manutenção da hipertensão em ratos espontaneamente hipertensos
SFRH/BD/32161/2006
Supervisor
Concluded
1996/09 - 1997 Libertação da taurina induzida por estimulação eléctrica do canal deferente de Rato: causas e possíveis mecanismos de libertação
PRAXIS XXI/BM/6734/95
Master Student Fellow
Universidade do Porto, Faculdade de Medicina , Portugal
Concluded

Contract

Designation Funders
2023 - Current A relevância da composição e estrutura da parede celular para a resistência ao nemátode da madeira do pinheiro em cenários de alterações climát
PTDC/ASP-SIL/3142/2020
Researcher
Ongoing
2021 - 2025 Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
LA/P/0008/2020
Researcher
Ongoing
2020 - 2024 Unidade de I&D Química-Física Molecular
UIDP/00070/2020
Researcher
2020 - 2024 Unidade de I&D Química-Física Molecular
UIDB/00070/2020
Researcher
2022 - 2023 Promoção do sucesso académico e redução do abandono escolar na U. Porto
POCH-02-53I2-FSE-000051
Researcher
Concluded
2020 - 2023 LAQV - Base - Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
UIDB/50006/2020
Researcher
Concluded
2020 - 2023 LAQV - programático - Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
UIDP/50006/2020
Researcher
Concluded
2018/06/30 - 2023 Novos ingredientes alimentares de plantas maritimas
PTDC/BAA-AGR/29305/2017
Co-Principal Investigator (Co-PI)
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Molecular Physical-Chemistry
UID/Multi/00070/2019
Universidade de Coimbra, Portugal

Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Associated Laboratory for Green Chemistry - Clean Technologies and Processes
UID/QUI/50006/2019
Universidade do Porto Faculdade de Ciências, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/07/01 - 2019/12/31 Impacto Bioquímico de Agentes Anticancerígenos de Platina e Paládio
PTDC/QEQ-MED/1890/2014
Researcher
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019 - 2019 Unidade de I&D Química-Física Molecular
UID/MULTI/00070/2019
Researcher
Concluded
2019 - 2019 Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
UID/QUI/50006/2019
Researcher
Concluded
2015 - 2018 Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
UID/QUI/50006/2013
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2014 - 2018 Unidade de I&D Química-Física Molecular
UID/MULTI/00070/2013
Researcher
Concluded
2013 - 2018 Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
UID/QUI/50006/2013
Researcher
Concluded
2010/05/01 - 2013/10/31 Desenvolvimento e validação de um modelo farmacocinético/farmacodinâmico para a individualização das doses de carboplatina e gemcitabina a administrar em doentes idosos com carcinoma de pulmão de não pequenas células avançado
PTDC/SAU-FCF/104448/2008
Researcher
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Characterization of adenosine receptors in mesenteric artery and their putative role in hypertension
E-73/2010
Principal investigator
Conselho de Reitores da Universidades Portuguesas
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 6 - 2011-2012
PEst-C/EQB/LA0006/2011
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/03/31 Novas abordagens terapêuticas no cancro: desenho racional e síntese de novos ligandos dos receptores A3 da adenosina
PTDC/QUI/70359/2006
Researcher
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2006/10/01 - 2010/09/29 Novo tipo de compostos orientados para receptores biológicos com potenciais aplicações farmacológicas
PDCT/QUI/56985/2004
Researcher
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2009/12/31 Protective role of adenosine in inflammatory processes: development of new therapeutic strategies
E-44/07
Researcher
Conselho de Reitores da Universidades Portuguesas
Concluded
2007/09/01 - 2009/07/31 Rational development of new A3 receptor ligands as new therapeutic approaches in cancer
new A3 receptor
Principal investigator
Universidade do Porto Faculdade de Farmácia
Concluded
2005/10/15 - 2008/10/14 Desenvolvimento de novos agentes anticancerígenos: derivados fenólicos de origem natural ou sintética - relações estrutura-actividade
POCI/QUI/55631/2004
Co-Principal Investigator (Co-PI)
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/10 - 2008/10 Desenvolvimento de novos agentes anticancerígenos: derivados fenólicos de origem natural ou sintética - relações estrutura-actividade
POCI/QUI/55631/2004
 Fundação para a Ciência e a Tecnologia
2005/05/01 - 2008/06/30 Papel protector da adenosina na inflamação vascular: mecanismos moleculares e implicações clínicas
POCI/SAU-FCF/60782/2004
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2005/05 - 2008/06 Papel protector da adenosina na inflamação vascular: mecanismos moleculares e implicações clínicas
POCI/SAU-FCF/60782/2004
 Fundação para a Ciência e a Tecnologia
2003/09/01 - 2006/12/30 Libertação neuronal de nucleotidases e o seu papel na modulação purinérgica da transmissão sináptica
POCTI/FCB/45549/2002
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2003 - 2006 Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto
POCTI/0226/2003
Researcher
Concluded
2000/11/01 - 2005/07/31 Role of adenosine in neurotransmitter release and synaptic activity from myoneural, vascular and hippocampal synapses: influence of calcium
POCTI/FCB/36545/1999
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2000/11 - 2005/07 Role of adenosine in neurotransmitter release and synaptic activity from myoneural, vascular and hippocampal synapses: influence of calcium
POCTI/FCB/36545/1999
 Fundação para a Ciência e a Tecnologia

Other

Designation Funders
2012 - 2013 Estudo desenvolvido para a Hovione (contrato n. 2) para estudo de efeito de um fármaco em animais
contrato n.2
Estudo desenvolvido para a Hovione (contrato n. 2)
REQUIMTE LAQV Porto, Portugal
Concluded
2011 - 2012 Estudo desenvolvido para a Hovione (contrato n. 1) para estudo de efeito de um fármaco em animais
Contrato n.1
Estudo desenvolvido para a Hovione (contrato n. 1)
REQUIMTE LAQV Porto, Portugal
 Hovione
Concluded
2006 - 2007 Bioensaios, análise, síntese e tecnologia
Basetec - ADI iniciativa Neotec
Researcher
Agência Nacional de Inovação SA
Concluded
Outputs

Publications

Book
  1. Image analysis in life sciences. 2009.
Book chapter
  1. Sousa, Joana; Diniz, Carmen. "Vascular Sympathetic Neurotransmission and Endothelial Dysfunction". In Endothelial Dysfunction - Old Concepts and New Challenges. InTech, 2018.
    10.5772/intechopen.72442
  2. Sousa, JB; Soares, AS; Fresco, P; Diniz, C; Pereira, Carmen. "Adenosine receptors in the vasculature: Physiology, pharmacology and therapeutic perspectives". 2014.
  3. Soares, AS; Sousa, JB; Diniz, C; Fresco, P. "Insights on the role of adenosine and adenosine receptors on melanoma: New therapeutic strategies". 2014.
  4. Diniz, C; Sousa, JB; Fresco, P. "Imaging receptors with Laser Scanning Confocal Microscopy: qualitative and quantitative analysis". 201-208. Formatex Research, 2014.
    Published
  5. Leito-Rocha, Ana; Beatriz, Joana; Diniz, Carmen. "Adenosinergic System in the Mesenteric Vessels". In The Cardiovascular System - Physiology, Diagnostics and Clinical Implications. InTech, 2012.
    10.5772/38534
  6. Diniz, C. "Microscopic image analysis using computer-assisted methodology to quantify immunstained receptors". In Microscopy: Science, Technology, Applications and Education, 1516-1525. Formatex Research Center, 2010.
  7. Diniz, C; Rocha-Pereira, C; Fresco, P. "Image analysis in microscopy – An historical perspective.". In Image Analysis in Life Science, 1-18. Research Signpost, 2009.
    Published
  8. Diniz, C; Rocha-Pereira, C; Foote, K; Leal, S; Fresco, P. "Quantitative image analysis of immunohistochemistry specimens using SACAIA method". In Image Analysis in Life Science, 19-33. Research Signpost, 2009.
    Published
Conference abstract
  1. Soares, AF; Diniz, C; Fresco, P. "A(3)-adenosine receptor effects on malignant melanoma cells". 2012.
  2. Rocha Pereira, C; Fresco, P; Arribas, SM; Gonzalez, MC; Conde, MV; Goncalves, J; Diniz, C. "PRESYNAPTIC ADENOSINE RECEPTORS IN SUPERIOR MESENTERIC ARTERY FROM SPONTANEOUSLY HYPERTENSIVE RATS: A FUNCTIONAL AND MORPHOLOGICAL STUDY". 2010.
  3. Rocha Pereira, C; Fresco, P; Arribas, SM; Gonzalez, MC; Conde, MV; Goncalves, J; Diniz, C. "EVIDENCE FOR A LESS EFFICIENT A1 RECEPTOR-MEDIATED INHIBITION OF NORADRENALINE RELEASE IN MESENTERIC ARTERIES FROM SPONTANEOUSLY HYPERTENSIVE RATS (SHR)". 2009.
  4. Fresco, P; Diniz, C; Goncalves, J. "Involvement of the PLC-PKC pathway on the interaction between alpha(2)-auto-receptors and the facilitatory adenosine A(2A) receptors in rat tail artery". 2004.
  5. Goncalves, J; Queiroz, G; Fresco, P; Diniz, C. "Interaction of facilitatory adenosine receptors and presynaptic-inhibitory receptors on noradrenaline release". 2004.
  6. Queiroz, G; Diniz, C; Goncalves, J. "Interactions between alpha(2)-autoreceptors and the A(1) and A(2A)-adenosine receptors on the modulation of noradrenaline release in the rat vas deferens". 2001.
  7. Diniz, C; Leal, S; Queiroz, G; Goncalves, J. "A differential distribution of adenosine receptors along the rat vas deferens revealed by immunohistochemistry". 2001.
  8. Leal, S; Diniz, C; Goncalves, J. "An immunohistochemistry study of P-1-receptors expression in the aorta and tail arteries of the rat". 2001.
  9. Diniz, C; Fresco, P; Queiroz, G; Goncalves, J. "Influence of alpha(2)-autoreceptor blockade on the A(2A)-mediated facilitation of noradrenaline release in rat isolated tail artery". 1999.
  10. Queiroz, G; Diniz, C; Fresco, P; Goncalves, J. "Facilitation by adenosine of noradrenaline release in rat isolated vas deferens is prevented by blockade of alpha(2)-autoreceptors". 1999.
  11. Fresco, P; Diniz, C; Goncalves, J. "Tissue and frequency dependence of the A(2A)-adenosine receptor mediated facilitation of noradrenaline release". 1997.
Conference paper
  1. Ana Cerquido; Martin Vojtek; Olga Viegas; Patricia Dias-Pereira; Carmen Diniz. "Adenosine Overcomes Triple-Negative Breast Cancer Resistance to Platinum-Derived Chemotherapeutic Drugs". 2022.
    10.3390/ECMC2022-13458
  2. Martin Vojtek; Maria P. M. Marques; Ana L. M. Batista de Carvalho; Helder Mota-Filipe; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Palladium-Spermine Complex (Pd2Spm) Triggers Autophagy and Caspase-Independent Cell Death in Triple-Negative Breast Cancer Cells". 2022.
    10.3390/ECMC2022-13469
  3. Rita Ribeiro-Oliveira; Zita E. Martins; Miguel Ângelo Faria; Joana Beatriz Sousa; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Natural Brewing Peptides with Enhanced Inhibitory Effects on Angiotensin I-Converting Enzyme". 2022.
    10.3390/ECMC2022-13426
  4. Sousa, JB; Fresco, P; Diniz, C. "Endothelial nitric oxide modulatory role on vascular sympathetic reactivity". 2013.
  5. Falcato Soares, A; Diniz, C; Fresco, P. "Characterization of Adenosine Receptors in Human and Mouse Melanoma Cells". 2013.
Journal article
  1. Carneiro, Tatiana J.; Carvalho, Ana L. M. Batista; Vojtek, Martin; Carmo, Inês F.; Marques, Maria Paula M.; Diniz, Carmen; Gil, Ana M.. "Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics". Cancer Cell International 23 1 (2023): http://dx.doi.org/10.1186/s12935-023-03124-0.
    Accepted • 10.1186/s12935-023-03124-0
  2. Martin Vojtek; Clara B. Martins; Raquel Ramos; Sara Gomes Duarte; Isabel M. P. L. V. O. Ferreira; Ana L. M. Batista de Carvalho; M. Paula M. Marques; Carmen Diniz. "Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity towards TNBC-Sensitive and -Resistant to Cisplatin". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041205.
    10.3390/pharmaceutics15041205
  3. Tatiana J. Carneiro; Martin Vojtek; Salomé Gonçalves-Monteiro; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232213773.
    10.3390/ijms232213773
  4. Ana Sofia Cerquido; Martin Vojtek; Rita Ribeiro-Oliveira; Olga Viegas; Joana Beatriz Sousa; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Unravelling Potential Health-Beneficial Properties of Corema album Phenolic Compounds: A Systematic Review". Pharmaceuticals (2022): https://doi.org/10.3390/ph15101231.
    10.3390/ph15101231
  5. Rita Ribeiro-Oliveira; Zita E. Martins; Miguel Ângelo Faria; Joana Beatriz Sousa; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Protein Hydrolysates from Brewing By-Products as Natural Alternatives to ACE-Inhibitory Drugs for Hypertension Management". Life (2022): https://doi.org/10.3390/life12101554.
    10.3390/life12101554
  6. Maria Sofia Vieira-Rocha; Joana Beatriz Sousa; Pilar Rodríguez-Rodríguez; Silvia Madaglena Arribas; Carmen Diniz. "Elevated Vascular Sympathetic Neurotransmission and Remodelling Is a Common Feature in a Rat Model of Foetal Programming of Hypertension and SHR". Biomedicines (2022): https://doi.org/10.3390/biomedicines10081902.
    10.3390/biomedicines10081902
  7. Ana Sofia Cerquido; Martin Vojtek; Rita Ribeiro-Oliveira; Salomé Gonçalves-Monteiro; Maria João Barroca; Aida Moreira da Silva; Olga Viegas; et al. "Corema album Leaves Mediate DNA Damage in Triple-Negative Breast Cancer Cells". Current Issues in Molecular Biology (2022): https://www.mdpi.com/1467-3045/44/8/246.
    10.3390/cimb44080246
  8. Maria Sofia Vieira-Rocha; Pilar Rodriguez-Rodriguez; Mariana Ferreira-Duarte; Miguel Faria; Joana Beatriz Sousa; Manuela Morato; Silvia Magdalena Arribas; Carmen Diniz. "Fetal Undernutrition Modifies Vascular RAS Balance Enhancing Oxidative Damage and Contributing to Remodeling". International Journal of Molecular Sciences 23 3 (2022): 1233-1233. https://doi.org/10.3390/ijms23031233.
    10.3390/ijms23031233
  9. Tatiana J. Carneiro; Martin Vojtek; Salomé Gonçalves-Monteiro; João R. Neves; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of Healthy Mice". Pharmaceutics 14 2 (2022): 259-259. https://doi.org/10.3390/pharmaceutics14020259.
    10.3390/pharmaceutics14020259
  10. Martin Vojtek; Salomé Gonçalves-Monteiro; Patrícia Šeminská; Katarína Valová; Loreto Bellón; Patrícia Dias-Pereira; Franklim Marques; et al. "Pd2Spermine Complex Shows Cancer Selectivity and Efficacy to Inhibit Growth of Triple-Negative Breast Tumors in Mice". Biomedicines (2022): https://www.mdpi.com/2227-9059/10/2/210.
    10.3390/biomedicines10020210
  11. Ribeiro-Oliveira, Rita; Martins, Zita E.; Sousa, Joana Beatriz; Ferreira, Isabel M.P.L.V.O.; Diniz, Carmen. "The health-promoting potential of peptides from brewing by-products: An up-to-date review". Trends in Food Science & Technology 118 (2021): 143-153. http://dx.doi.org/10.1016/j.tifs.2021.09.019.
    10.1016/j.tifs.2021.09.019
  12. Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Impact of the Pd2Spm (Spermine) Complex on the Metabolism of Triple-Negative Breast Cancer Tumors of a Xenograft Mouse Model". International Journal of Molecular Sciences 22 19 (2021): 10775-10775. https://doi.org/10.3390/ijms221910775.
    10.3390/ijms221910775
  13. Pilar Rodríguez-Rodríguez; Maria Sofía Vieira-Rocha; Begoña Quintana-Villamandos; Ignacio Monedero-Cobeta; Parichat Prachaney; Angel Luis López de Pablo; Maria del Carmen González; et al. "Implication of RAS in Postnatal Cardiac Remodeling, Fibrosis and Dysfunction Induced by Fetal Undernutrition". Pathophysiology (2021): https://doi.org/10.3390/pathophysiology28020018.
    10.3390/pathophysiology28020018
  14. Salomé Gonçalves-Monteiro; Rita Ribeiro-Oliveira; Maria Sofia Vieira-Rocha; Martin Vojtek; Joana B. Sousa; Carmen Diniz. "Insights into Nuclear G-Protein-Coupled Receptors as Therapeutic Targets in Non-Communicable Diseases". Pharmaceuticals 14 5 (2021): 439-439. https://doi.org/10.3390/ph14050439.
    10.3390/ph14050439
  15. Carneiro, Tatiana J.; Araújo, Rita; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Diniz, Carmen; Batista de Carvalho, Ana L. M.; Marques, M. Paula M.; Gil, Ana M.. "Novel Insights into Mice Multi-Organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent". Metabolites 11 2 (2021): 114. http://dx.doi.org/10.3390/metabo11020114.
    10.3390/metabo11020114
  16. Martin Vojtek; Salomé Gonçalves-Monteiro; Edgar Pinto; Sára Kalivodová; Agostinho Almeida; MPM Marques; Ana Batista de Carvalho; et al. "Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd2Spm) in Mice". Pharmaceuticals (2021): https://www.mdpi.com/1424-8247/14/2/173.
    10.3390/ph14020173
  17. Daniela Patinha; Carla Abreu; Carla Carvalho; Olga Mariana Cunha; Mariana Mota; Joana Afonso; Teresa Sousa; et al. "Adenosine A2A and A3 Receptors as Targets for the Treatment of Hypertensive-Diabetic Nephropathy". Biomedicines 8 11 (2020): 529-529. https://doi.org/10.3390/biomedicines8110529.
    10.3390/biomedicines8110529
  18. Mariana Ferreira-Duarte; Joana Beatriz Sousa; Carmen Diniz; Teresa Sousa; Margarida Duarte-Araújo; Manuela Morato. "Experimental and Clinical Evidence of Endothelial Dysfunction in Inflammatory Bowel Disease". Current Pharmaceutical Design (2020): https://doi.org/10.2174/1381612826666200701212414.
    10.2174/1381612826666200701212414
  19. Maria S. Vieira-Rocha; Joana B. Sousa; Pilar Rodriguez-Rodriguez; Manuela Morato; Silvia M. Arribas; Carmen Diniz. "Insights into sympathetic nervous system and GPCR interplay in fetal programming of hypertension: a bridge for new pharmacological strategies". Drug Discovery Today (2020): https://doi.org/10.1016/j.drudis.2020.01.019.
    10.1016/j.drudis.2020.01.019
  20. Martin Vojtek; Edgar Pinto; Salomé Gonçalves-Monteiro; Agostinho Almeida; M. P. M. Marques; Helder Mota-Filipe; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies". Analytical Methods (2020): https://doi.org/10.1039/D0AY01328E.
    10.1039/D0AY01328E
  21. Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Carmen Diniz; Ana L.M. Batista de Carvalho; Maria Paula M. Marques; Ana M. Gil. "Multi-Organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisplatin in Mice". Metabolites 9 11 (2019): 279-279. https://doi.org/10.3390/metabo9110279.
    10.3390/metabo9110279
  22. Ribeiro-Oliveira, Rita; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Vieira-Rocha, Maria Sofia; Sousa, Joana B.; Gonçalves, Jorge; Diniz, Carmen. "Nuclear G-protein-coupled receptors as putative novel pharmacological targets". Drug Discovery Today 24 11 (2019): 2192-2201. http://dx.doi.org/10.1016/j.drudis.2019.09.003.
    Published • 10.1016/j.drudis.2019.09.003
  23. Patinha, Daniela; Carvalho, Carla; Abreu, Carla; Cunha, Olga M.; Mota, Mariana C.; Afonso, Joana; Albino-Teixeira, António; Diniz, Carmen; Morato, Manuela. "Diabetes downregulates renal adenosine A2A receptors in an experimental model of hypertension". PLOS ONE 14 5 (2019): e0217552. http://dx.doi.org/10.1371/journal.pone.0217552.
    10.1371/journal.pone.0217552
  24. Vojtek, Martin; Marques, Maria P.M.; Ferreira, Isabel M.P.L.V.O.; Mota-Filipe, Hélder; Diniz, Carmen. "Anticancer activity of palladium-based complexes against triple-negative breast cancer". Drug Discovery Today (2019): http://dx.doi.org/10.1016/j.drudis.2019.02.012.
    10.1016/j.drudis.2019.02.012
  25. Viegas, Olga; Faria, Miguel A.; Sousa, Joana B.; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Suliburska, Joanna; Diniz, Carmen; Ferreira, Isabel M.P.L.V.O.. "Delphinidin-3-O-glucoside inhibits angiogenesis via VEGFR2 downregulation and migration through actin disruption". Journal of Functional Foods 54 (2019): 393-402. http://dx.doi.org/10.1016/j.jff.2019.01.039.
    10.1016/j.jff.2019.01.039
  26. Ana Sousa-Oliveira; Ana Brandão; Martin Vojtek; Salomé Gonçalves-Monteiro; Joana B. Sousa; Carmen Diniz. "Vascular impairment of adenosinergic system in hypertension: increased adenosine bioavailability and differential distribution of adenosine receptors and nucleoside transporters". Histochemistry and Cell Biology (2018): https://doi.org/10.1007/s00418-018-1743-0.
    10.1007/s00418-018-1743-0
  27. Vieira-Rocha, M.S.; Rodríguez-Rodríguez, P.; Sousa, J.B.; González, M.C.; Arribas, S.M.; López de Pablo, A.L.; Diniz, C.. "Vascular angiotensin AT1 receptor neuromodulation in fetal programming of hypertension". Vascular Pharmacology (2018): http://dx.doi.org/10.1016/j.vph.2018.10.003.
    10.1016/j.vph.2018.10.003
  28. Sousa, JB; Pereira, Carmen; Fresco, P; Diniz, C; Goncalves, J. "Adenosine Receptor Ligands on Cancer Therapy: A Review of Patent Literature". Recent Patents on Anti-Cancer Drug Discovery 13 1 (2018): 40-69.
    Published • 10.2174/1574892812666171108115959
  29. Joana Sousa; Carmen Diniz. "The Adenosinergic System as a Therapeutic Target in the Vasculature: New Ligands and Challenges". Molecules 22 5 (2017): 752-752. https://doi.org/10.3390/molecules22050752.
    10.3390/molecules22050752
  30. Diniz, Carmen; Suliburska, Joanna; Ferreira, Isabel M.P.L.V.O.. "New insights into the antiangiogenic and proangiogenic properties of dietary polyphenols". Molecular Nutrition & Food Research 61 6 (2017): 1600912. http://dx.doi.org/10.1002/mnfr.201600912.
    10.1002/mnfr.201600912
  31. Ana L. M. Batista de Carvalho; Aamir Ahmad; Paula S. C. Medeiros; Francisco M. Costa; Vanessa P. Ribeiro; Joana B. Sousa; Carmen Diniz; Maria P. M. Marques. "Anti-Invasive and Anti-Proliferative Synergism between Docetaxel and a Polynuclear Pd-Spermine Agent". PLOS ONE 11 11 (2016): e0167218-e0167218. https://doi.org/10.1371/journal.pone.0167218.
    10.1371/journal.pone.0167218
  32. Sousa, JB; Vieira Rocha, MS; Arribas, SM; Gonzalez, MC; Fresco, P; Diniz, C. "Endothelial and Neuronal Nitric Oxide Activate Distinct Pathways on Sympathetic Neurotransmission in Rat Tail and Mesenteric Arteries". PLOS ONE (2015):
    10.1371/journal.pone.0129224
  33. Soares, Ana Sofia; Costa, Vera Marisa; Diniz, Carmen; Fresco, Paula. "Inosine Strongly Enhances Proliferation of Human C32 Melanoma Cells through PLC-PKC-MEK1/2-ERK1/2 and PI3K Pathways". Basic & Clinical Pharmacology & Toxicology 116 1 (2015): 25-36.
    10.1111/bcpt.12280
  34. Sousa, J.B.; Fresco, P.; Diniz, C.. "Endothelial dysfunction impairs vascular neurotransmission in tail arteries". Neurochemistry International 80 (2015): 7-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919372516&partnerID=MN8TOARS.
    10.1016/j.neuint.2014.11.001
  35. Vidal, H; Goncalinho, H; Monteiro, J; das Neves, J; Sarmento, B; Diniz, C; Fresco, P. "Development and validation of a rapid and simple reversed-phase HPLC method for the determination of gemcitabine in human plasma". International Journal of Pharmacy and Pharmaceutical Sciences (2014):
  36. Sousa, JB; Vieira Rocha, MS; Sa, C; Ferreirinha, F; Correia de Sa, P; Fresco, P; Diniz, C. "Lack of Endogenous Adenosine Tonus on Sympathetic Neurotransmission in Spontaneously Hypertensive Rat Mesenteric Artery". PLOS ONE (2014):
    10.1371/journal.pone.0105540
  37. Soares, Ana S.; Costa, Vera M.; Diniz, Carmen; Fresco, Paula. "Combination of Cl-IB-MECA with paclitaxel is a highly effective cytotoxic therapy causing mTOR-dependent autophagy and mitotic catastrophe on human melanoma cells". Journal of Cancer Research and Clinical Oncology 140 6 (2014): 921-935.
    10.1007/s00432-014-1645-z
  38. Soares, A.S.; Costa, V.M.; Diniz, C.; Fresco, P.. "The combination of Cl-IB-MECA with paclitaxel: A new anti-metastatic therapeutic strategy for melanoma". Cancer Chemotherapy and Pharmacology 74 4 (2014): 847-860. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925546690&partnerID=MN8TOARS.
    10.1007/s00280-014-2557-y
  39. Rocha-Pereira, C.; Sousa, J. B.; Vieira-Rocha, M. S.; Fresco, P.; Goncalves, J.; Diniz, C.. "Differential inhibition of noradrenaline release mediated by inhibitory A(1)-adenosine receptors in the mesenteric vein and artery from normotensive and hypertensive rats". Neurochemistry International 62 4 (2013): 399-405.
    10.1016/j.neuint.2013.02.010
  40. Soares, Ana S.; Costa, Vera M.; Diniz, Carmen; Fresco, Paula. "Potentiation of cytotoxicity of paclitaxel in combination with Cl-IB-MECA in human C32 metastatic melanoma cells: A new possible therapeutic strategy for melanoma". Biomedicine & Pharmacotherapy 67 8 (2013): 777-789.
    10.1016/j.biopha.2013.08.003
  41. Rocha-Pereira, Carolina; Magdalena Arribas, Silvia; Fresco, Paula; Carmen Gonzalez, Maria; Goncalves, Jorge; Diniz, Carmen. "Impaired Inhibitory Function of Presynaptic A(1)-Adenosine Receptors in SHR Mesenteric Arteries". Journal of Pharmacological Sciences 122 2 (2013): 59-70.
    10.1254/jphs.12266FP
  42. Fresco, P.; Borges, F.; Marques, M.; Diniz, C.. "The Anticancer Properties of Dietary Polyphenols and its Relation with Apoptosis". Current Pharmaceutical Design 16 1 (2010): 114-134. http://dx.doi.org/10.2174/138161210789941856.
    10.2174/138161210789941856
  43. Diniz, C.; Borges, F.; Santana, L.; Uriarte, E.; Oliveira, J. M. A.; Goncalves, J.; Fresco, P.. "Ligands and therapeutic perspectives of adenosine A(2A) receptors". Current Pharmaceutical Design 14 17 (2008): 1698-1722.
    10.2174/138161208784746842
  44. Chaves, S.; Gil, M.; Canário, S.; Jelic, R.; Romão, M.J.; Trincão, J.; Herdtweck, E.; et al. "Biologically relevant O,S-donor compounds. Synthesis, molybdenum complexation and xanthine oxidase inhibition". Dalton Transactions 13 (2008): 1773-1782. http://www.scopus.com/inward/record.url?eid=2-s2.0-40849130962&partnerID=MN8TOARS.
    10.1039/b717172b
  45. Leal, S; Carlos, SA; Goncalves, J; Fresco, P; Diniz, C. "Immunohistochemical Characterization of Adenosine Receptors in Rat Aorta and Tail Arteries". MICROSCOPY RESEARCH AND TECHNIQUE (2008):
    10.1002/jemt.20609
  46. Fresco, Paula; Oliveira, Jorge M. A.; Kunc, Filip; Soares, Ana Sofia; Rocha-Pereira, Carolina; Goncalves, Jorge; Diniz, Carmen. "A(2A) adenosine-receptor-mediated facilitation of noradrenaline release in rat tail artery involves protein kinase C activation and beta gamma subunits formed after alpha(2)-adrenoceptor activation". Neurochemistry International 51 1 (2007): 47-56.
    10.1016/j.neuint.2007.03.009
  47. Diniz, C; Leal, S; Logan, K; Rocha Pereira, C; Soares, AS; Rocha, E; Goncalves, J; Fresco, P. "Immunohistochemical localization of angiotensin II receptor types 1 and 2 in the mesenteric artery from spontaneously hypertensive rats". MICROSCOPY RESEARCH AND TECHNIQUE (2007):
    10.1002/jemt.20453
  48. Leal, S; Diniz, C; Sa, C; Goncalves, J; Soares, AS; Rocha Pereira, C; Fresco, P. "Semiautomated computer-assisted image analysis to quantify 3,3 '-diaminobenzidine tetrahydrochloride-immuno stained small tissues". ANALYTICAL BIOCHEMISTRY (2006):
    10.1016/j.ab.2006.07.017
  49. Fresco, P.; Borges, F.; Diniz, C.; Marques, M.P.M.. "New insights on the anticancer properties of dietary polyphenols". Medicinal Research Reviews 26 6 (2006): 747-766. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750958329&partnerID=MN8TOARS.
    10.1002/med.20060
  50. Marques, M.P.M.; Borges, F.; Sousa, J.; Calheiros, R.; Garrido, J.; Gaspar, A.; Antunes, F.; Diniz, C.; Fresco, P.. "Cytotoxic and COX-2 inhibition properties of hydroxycinnamic derivatives". Letters in Drug Design and Discovery 3 5 (2006): 316-320. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745603707&partnerID=MN8TOARS.
    10.2174/157018006777574212
  51. Diniz, C.; Fresco, P.; Gonçalves, J.. "Regional differences in extracellular purine degradation in the prostatic and epididymal portions of the rat vas deferens". Clinical and Experimental Pharmacology and Physiology 32 9 (2005): 721-727. http://www.scopus.com/inward/record.url?eid=2-s2.0-26944496887&partnerID=MN8TOARS.
    10.1111/j.1440-1681.2005.04252.x
  52. Fresco, P.; Diniz, C.; Gonçalves, J.. "Facilitation of noradrenaline release by activation of adenosine A 2A receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery". Cardiovascular Research 63 4 (2004): 739-746. http://www.scopus.com/inward/record.url?eid=2-s2.0-4043096370&partnerID=MN8TOARS.
    10.1016/j.cardiores.2004.05.015
  53. Diniz, C.; Fresco, P.; Leal, S.; Gonçalves, J.. "Adenosine receptors involved in modulation of noradrenaline release in isolated rat tail artery". European Journal of Pharmacology 504 1-2 (2004): 17-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-6944256808&partnerID=MN8TOARS.
    10.1016/j.ejphar.2004.09.048
  54. Diniz, C; Leal, S; Goncalves, J. "Regional differences in the adenosine A(2) receptor-mediated modulation of contractions in rat vas deferens". EUROPEAN JOURNAL OF PHARMACOLOGY (2003):
    10.1016/S0014-2999(02)02926-6
  55. Fresco, P.; Diniz, C.; Queiroz, G.; Gonçalves, J.. "Release inhibitory receptors activation favours the A 2A-adenosine receptor-mediated facilitation of noradrenaline release in isolated rat tail artery". British Journal of Pharmacology 136 2 (2002): 230-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036267399&partnerID=MN8TOARS.
    10.1038/sj.bjp.0704686
  56. Queiroz, G; Diniz, C; Goncalves, J. "Facilitation of noradrenaline release by adenosine A(2A) receptors in the epididymal portion and adenosine A(2B) receptors in the prostatic portion of the rat vas deferens". European Journal of Pharmacology 448 1 (2002): 45-50.
    10.1016/S0014-2999(02)01906-4
  57. Diniz, C.; Da Cruz Fresco, P.; Gonçalves, J.. "Taurine release in the rat vas deferens is modulated by Ca2+ and is independent of contractions". European Journal of Pharmacology 376 3 (1999): 273-278. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033055521&partnerID=MN8TOARS.
    10.1016/s0014-2999(99)00388-x
Report
  1. Ana Sofia Cerquido; Martin Vojtek; Rita Ribeiro-Oliveira; Olga Viegas; Joana Beatriz Sousa; Isabel M.P.L.V.O. Ferreira; Carmen Diniz. 2022. Unravelling potential health-beneficial properties of Corema album phenolic compounds: a systematic review. https://doi.org/10.37766/inplasy2022.8.0022.
    10.37766/inplasy2022.8.0022
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023 Influence of fetal programming of hypertension on angiotensin receptors expression Renin-angiotensin-aldosterone system in health and disease: new insights into a classic system
(Portugal)
2023 Development of Palladium-spermine complex (Pd2Spm) for triple negative breast cancer cells – in vitro and in vivo I Congresso Iberoamericano de Ciências Farmacêuticas
2023 Brewing bioactive peptides as angiotensin-converting enzyme inhibitors Renin-angiotensin-aldosterone system in health and disease: new insights into a classic system
(Portugal)
2023 Interplay between sympathetic nervous system and fetal programming of hypertension: tonic activation mediated by Angiotensin II Renin-angiotensin-aldosterone system in health and disease: new insights into a classic system
(Portugal)
2023 Brewing bioactive peptides as angiotensin-converting enzyme inhibitors: Sex differences in spontaneously hypertensive rats 18 YES meeting
(Portugal)
2022 Interplay between sympatehtic nervous system nad GPCR in fetal programming of hypertension 25th European Council for Cardiovascular Research (ECCR)
2022 Alterations of renin-angiotensin and sympathetic nervous systems in fetal programming of hypertension Symposium in materno-fetal health, Faculdad de Medicina Autonoma de Madrid
(Spain)
2022 Natural brewing peptides with enhanced inhibitory effect towards Angiotensing Converting Enzyme Em The 8th International Electronic Conference on Medicinal Chemistry.
2022 Adenosine Overcomes Triple Negative Breast Cancer Resistance to Platin-Derived Chemotherapeutic Drugs The 8th International Electronic Conference on Medicinal Chemistry
2022 Palladium-spermine complex (Pd2Spm) triggers autophagy and caspase-independent cell death in triple-negative breast cancer cells The 8th International Electronic Conference on Medicinal Chemistry
2022 In vivo NMR metabolomics: triple negative breast cancer response to anticancer drug Pd2(Spermine)”. Em 8th International Iberian Biophysics Congress
(Spain)
2022 Impact of adenosine on sensitivity of triple negative breast cancer cells towards platin-derived chemotherapeutic drugs” IJUP-2022
2022 Promising synergistic effect of blackcurrant anthocyanins and docetaxel on triple negative breast cancer cells IJUP-2022
2022 Impact of adenosine on sensitivity of triple negative breast cancer cells towards platin-derived chemotherapeutic drugs I3A – LAQV, Reunião Anual. 2019, Mindful nutrition: knowing both benefits and risks of foods
2022 Developing and understanding of anticancer effects of metal based drugs against breast cancer I3A – LAQV, Reunião Anual. 2019, Mindful nutrition: knowing both benefits and risks of foods
2022 Exploit the anticancer potential of an extract with high phenolic content of Corema album leaves on triple negative breast cancer (TNBC) I3A – LAQV, Reunião Anual. 2019, Mindful nutrition: knowing both benefits and risks of foods
2021/05 Promising In Vitro Biological Activity of Extracts from Corema Album Leaves IJUP 21
(Porto, Portugal)
2020/02/07 ANTICANCER PALLADIUM-SPERMINE COMPLEX: IN VIVO ACTIVITY AGAINST TRIPLE-NEGATIVE BREAST CANCER IN MICE SPF 2020 - L REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVIII REUNIÃO FARMACOLOGIA CLÍNICA, XIX REUNIÃO TOXICOLOGIA
(Coimbra, Portugal)
2019/02/07 MESENTERIC ARTERY HYPERSYMPATHETIC ACTIVATION IN AN ANIMAL MODEL OF FETAL PROGRAMMING OF HYPERTENSION SPF2019 - XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVII REUNIÃO FARMACOLOGIA CLÍNICA, XVIII REUNIÃO TOXICOLOGIA
(Porto, Portugal)
2018/02/06 ANTICANCER METAL COMPLEXES WITH POLYAMINES AGAINST BREAST CANCER: CELLULAR DRUG UPTAKE AND SELECTIVE CYTOTOXICITY SPF 2018 - XLVIII REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVI REUNIÃO FARMACOLOGIA CLÍNICA, XVII REUNIÃO TOXICOLOGIA
(Lisboa, Portugal)
2018/02 NOVEL COST-EFFECTIVE ICP-MS METHOD FOR PHARMACO-TOXICOKINETIC STUDIES OF PLATINUM AND PALLADIUM-BASED DRUGS IN VARIETY OF ANIMAL TISSUES SPF 2018
(Lisboa, Portugal)
2017 Impact of presynaptic Angiontensin II receptor AT1 in an animal model of Fetal Programming of Hypertension
2016/06/30 Impact of presynaptic angiotensin II receptors in an animal model of fetal programming hypertension FarmaMadrid
(Madrid, Spain)
2016/06/30 Synergic effect induced by docetaxel and Pd-spermine complex in human triple negative breast cancer FarmaMadrid
(Madrid, Spain)
2016/06/30 Characterization of adenosine receptors and nucleoside equilibrative transporters distribution in spontaneously hypertensive mesenteric arteries and veins FarmaMadrid
(Madrid, Spain)
2016/02 Distribution profile of adenosine receptors and equilibrative transporters in the mesenteric vessels of spontaneously hypertensive rats SPF 2016
(Portugal)
2015/02 Distribution profile of adenosine receptors in the kidney of SHR diabetic rats SPF 2015
(Portugal)
2015/02 Distribution profile of adenosine receptors in the mesenteric vessels of spontaneously hypertensive rats IJUP
(Porto, Portugal)
2015/02 Adenosine Equilibrative Transporters: Distribution and quantification profile in mesenteric vessels IJUP
(Porto, Portugal)
2014 Loss of inhibitory adenosine tonus in mesenteric arteries of spontaneously hypertensive rats: a possible role for the redistribution of A1 receptors on sympathetic nerves SPF 2014
2013 Relationship between NADPH oxidase and nNOS with sympathetuc nerve terminals in mesenteric adevntitial layer from spontaneous hypertensive rats SPF 2013
2013 Noradrenaline release from vascular postganglionic sympathetic terminal is enhanced by endotelial nitric oxide. SPF 2013 - XLIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXI Reunião de Farmacologia Clínica e XII Reunião de Toxicologia
(Portugal)
2013 Distribution of adenosine receptors in the glomeruli of SHR diabetic rats SPF 2013 -XLIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXI Reunião de Farmacologia Clínica e XII Reunião de Toxicologia
(Portugal)
2013 Potentiation of paclitaxel cytoxicity by CL-IB-MECA in human C32 melanoma cells: possible involvement of the intrinsic apoptotic pathway SPF 2013 XLIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXI Reunião de Farmacologia Clínica e XII Reunião de Toxicologia
(Portugal)
2012 Role of A3 Adenosine Receptor on Malignant Melanoma Cells SPF 2012 XLII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXX Reunião de Farmacologia Clínica e XI Reunião de Toxicologia
(Portugal)
2012 Pharmacokinetic-Pharmacodynamic Model For Dosification Of Carboplatin-Gemcitabine Scheme In Elderly Advanced Non-Small Cell Lung Cancer Patients – Analytical Phase SPF 2012 XLII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXX Reunião de Farmacologia Clínica e XI Reunião de Toxicologia
(Portugal)
2011 Pharmacokinetic-Pharmacodynamic support for a reduction of carboplatin dosis in elderly advanced non-small cell lung cancer patients XLI Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIX Reunião de Farmacologia Clínica
2010 Biological activity of caffeic acid derivatives: antioxidant and anti-inflammatory effects IJUP
(Portugal)
2010 Putative role of presynaptic adenosine receptors in hypertension: a functional and morphological study in the mesenteric artery XVII Congresso Nacional de Bioquimica
(Portugal)
2010 Chemopreventive effect of a green tea catechin, EGCG, on Human melanoma cells IJUP
(Portugal)
2010 Optimisation of immunohistochemical procedures to detect adenosine transporters in vessels IJUP
(Portugal)
2009 Presynaptic A1 receptors in SHR superior mesenteric artery and vein: functional and morphological characterization. XL Reunião Anual da Sociedade Portuguesa de Farmacologia e XXVIII Reunião de Farmacologia Clínica
(Portugal)
2009 Cytotoxic effects of (-)-epigallocatechin-3-gallate (EGCG) on Human A-375 Melanoma cells XL Reunião Anual da Sociedade Portuguesa de Farmacologia e XXVIII Reunião de Farmacologia Clínica
(Portugal)
2009 Intervenção Farmacêutica no Acompanhamento de Idosos Institucionalizados 1as Jornadas Científicas de Farmácia Comunitária
(Portugal)
2009 A3 adenosine receptor location and function in spontaneouly hypertensive rat mesenteric bed XL Reunião Anual da Sociedade Portuguesa de Farmacologia e XXVIII Reunião de Farmacologia Clínica
(Portugal)
2009 Inhibition of xanthine oxidase by cafeic and sinaptic acid derivatives XL Reunião Anual da Sociedade Portuguesa de Farmacologia e XXVIII Reunião de Farmacologia Clínica
(Portugal)
2008 Comparison of Adenosine A2A and A2B Receptors Distribution Patterns in the Mesenteric vein and Artery from Normotensive and Spontaneously Hypertensive Rats using Immunohistochemistry SPF 2008
(Portugal)
2007 Immunohistochemical distribution of adenosine A2A and A2B receptors in the mesenteric vein and artery from normal and spontaneously hypertensive rats SPF 2007 - XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXV Reunião de Farmacologia Clinica
(Portugal)
2006 Quantitative analysis of adenosine receptors distribution in rat abdominal aorta and tail arteries. XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clinica
(Portugal)
2006 The medicinal chemistry artwork on the development of new phenolic antioxidants XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clinica
(Portugal)
2006 Medicinal Chemistry in the Design of Novel Anticancer Agents. edicinal Chemistry in the 21st Century (Sociedade Portuguesa de Química
(Portugal)
2006 Immunohistochemical distribution of adenosine A1 receptors in the mesenteric vein and artery from normal and spontaneous hypertensive rats. XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clinica
(Portugal)
2004 New insights in the mechanisms of cross-talk between alpha2-autoreceptores and A2A receptors in rat tail artery. XIX Congresso Nacional de Bioquímica
(Portugal)
2004 Interaction of facilitatory adenosine receptors and presynaptic-inhibitory receptors on noradrenaline release 4th EPHAR
(Porto, Portugal)
2003 A2A-adenosine recpetor mediated facilitaion of noradrenaline release in rat tail artery requires activation of both PKA and PKC XXIV Reunião Anual da Sociedade Portuguesa de Farmacologia e XXII Reunião de Farmacologia Clinica
2003 A PKC-dependent pathway is involved on the interaction between modulation of noradrenaline release mediated by the ¿2-adrenoceptor- and A2A-adenosine receptors in rat tail artery XI Meeting of adrenergic Mechanisms
2002 The purine degradation system may differ in the epididymal and prostatic portions of the rat vas deferens XXXIII Reunião da Sociedade Portuguesa de Farmacologia e XXI Reunião de Farmacologia Clínica
2002 Quantative analysis of A2 adenosine receptor immunoreactivity in rat arteries XXXIII Reunião da Sociedade Portuguesa de Farmacologia e XXI Reunião de Farmacologia Clínica
2002 Distribution of adenosine receptors in rat heart revealed by immunohistochemistry XXXIII Reunião da Sociedade Portuguesa de Farmacologia e XXI Reunião de Farmacologia Clínica
2002 Evidence for the involvement of A2B receptors on the modulation of [3H]-noradrenaline release in rat tail artery XXXIII Reunião da Sociedade Portuguesa de Farmacologia e XXI Reunião de Farmacologia Clínica
2001 Regional differences of P1-receptor mediated modulation of purinergic and adrenergic contractions in the rat vas deferens XXXII Reunião da Sociedade Portuguesa de Farmacologia e XX Reunião de Farmacologia Clínica
2001 Immunohistochemical characterization of P1-receptors in rat tail artery XXXII Reunião da Sociedade Portuguesa de Farmacologia e XX Reunião de Farmacologia Clínica
2001 Evidences for regional differences in the adenosine receptor modulation of responses to exogenous noradrenaline in the prostatic and epididymal portions of the rat vas deferens First Iberian Purinergic Meeting
2001 A2A-adenosine receptor mediated facilitation of noradrenaline release in rat tail artery: evidence for the occurrence of an interaction with ¿¿-adrenoceptors First Iberian Purinergic Meeting
2000 Differential adenosine-receptor modulation of responses to noradrenaline in the epididymal and prostatic portions of the rat vas deferens XXXI Reunião da Sociedade Portuguesa de Farmacologia e XIX Reunião de Farmacologia Clínica
2000 The efficacy of the ATP inactivation system may differ in the epididymal and prostatic portions of the rat vas deferens XXXI Reunião da Sociedade Portuguesa de Farmacologia e XIX Reunião de Farmacologia Clínica
2000 Immunohistochemical localization of adenosine receptor subtypes in the prostatic and epididymal portions of the rat vas deferens XXXI Reunião da Sociedade Portuguesa de Farmacologia e XIX Reunião de Farmacologia Clínica
2000 Interaction between ¿¿¿autoreceptors and adenosine receptors on the modulation of noradrenaline release in the epididymal portion of the rat vas deferens XXXI Reunião da Sociedade Portuguesa de Farmacologia e XIX Reunião de Farmacologia Clínica
2000 Regional differences on the adenosine–receptor mediated modulation of noradrenaline release in the rat vas deferens X Meeting of adrenergic Mechanisms
2000 Influence of adenosine in the adrenergic transmission in the epididiymal and prostatic portions of the rat vas deferens XVI Latin American Congress of Pharmacology
1999 Evidences for regional differences in the purinergic modulation of noradrenaline release in the rat vas deferens XXX Reunião da Sociedade Portuguesa de Farmacologia e XVIII Reunião de Farmacologia Clínica
1999 Influence of ¿2-autoreceptor blockade on the A2A- mediated facilitation of noradrenaline release in rat isolated tail artery Joint Meeting of The British and The Portuguese Pharmacological Societies
1999 Facilitation by adenosine of noradrenaline release in rat isolated vas deferens is prevented by blockade of ¿2-autoreceptors Joint Meeting of The British and The Portuguese Pharmacological Societies
1998 Purinergic facilitation of 3H-noradrenaline release in rat tail artery: influence of tonic noradrenergic modulation XXIX Reunião da Sociedade Portuguesa de Farmacologia e XVII Reunião de Farmacologia Clínica
1998 Modulation of noradrenaline release in rat tail artery mediated by P1 receptors: the role of A1 and A2A receptors 9th International Symposium on Vascular Neuroeffector Mechanisms
1997 43. Taurine release in rat vas deferens is dependent on stimulation conditions but is not secondary to contractions Joint Meeting of the Portuguese and Nordic Pharmacological Societies
1997 Calcium inhibits the electrically-evoked taurine release in rat vas deferens Joint Meeting of the Portuguese and Nordic Pharmacological Societies
1997 Influence of inhibitors of anion transporters and/or anion channels on the electrically-evoked taurine release in rat vas deferens Joint Meeting of the Portuguese and Nordic Pharmacological Societies

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - Current Blackcurrant anthocyanins: A promising dietary strategy as chemopreventive and chemotherapy adjuvant for triple negative breast cancer? (Doutoramento)
Co-supervisor
2023 - Current Unlocking Triple-Negative Breast Cancer resistance in 3D models
Co-supervisor
2023 - Current Reversão da resistência do cancro da mama triplo negativo ao tratamento co Sabrina Atella Barreiram o fármaco comum Cisplatina
Co-supervisor
2023 - Current Adenosine receptors in triple negative breast cancer: location of receptors in the nuclei as putative biomarker of cancer resistance (ERASMUS)
Supervisor
2022 - Current “Oral Administration – An in Vitro Approach for Digestion, Absorption and Metabolism (ERASMUS)
Supervisor
2022 - Current “Impact of Oral Administration in BSG/BSY Bioactivities (ERASMUS)
Supervisor
2022 - Current “GPCRs’ inhibition in vascular cells: impact in hypertension (ERASMUS(
Supervisor
2021 - Current O efeito de Pd2Espermina (SPM) no metaboloma lipofilico no cérebro de murganhos
Co-supervisor
2021 - Current Atividade anticancerígena de novos complexos trinucleados de platina e paládio com espermidina contra o cancro da mama
Co-supervisor
2021 - Current Estratégia de Combate à Resistência de Células de Cancro da Mama: Sinergismo de Fármacos Derivados de Platina (II) com Adenosina
Co-supervisor
2021 - Current Bioactivity studies of protein hydrolysates from brewing by-products in rat primary vascular cell cultures (ERASMUS)
Supervisor
2020 - Current Recovery of peptides from brewing by-products to control hypertension (Doutoramento)
Supervisor
 Programa Doutoral em Ciências (PhD)
2020 - Current Metabolic biomarkers of chemotherapeutic efficacy of potential novel drugs in breast cancer: a metabolomics study (Doutoramento)
Co-supervisor
2020 - Current Breast cancer and anti-inflammatory properties of plant extracts (ERASMUS)
Supervisor
2020 - Current Antiproliferative effects of metal-based compounds in breast cancer cells (ERASMUS)
Supervisor
2019 - 2030 Does adenosine enhance metal-based drugs sensitivity in breast cancer cells? (ERASMUS)
Supervisor
2023 - 2024 Antiproliferative activity of new diarylisoxazole compound DHl1 on leukemia cell Lines (Doutoramento)
Co-supervisor
2017 - 2023 Preclinical Pharmacology of Novel Palladium-Based Antineoplastic Agents for Breast Cancer (Doutoramento)
Supervisor of Martin Vojtek
Universidade do Porto Faculdade de Farmácia, Portugal
2021 - 2022 Impact of Adenosine on Sensitivity of Triple Negative Breast Cancer Cells Towards Platin-Derived Chemotherapeutic Drugs (Mestrado)
Supervisor
2021 - 2022 Impact of the Nucleoside, Adenosine, in Triple Negative Breast Cancer (Licenciatura)
Supervisor
2021 - 2022 PDE3 inhibition on the experimental sepsis model (Doutoramento)
Co-supervisor
2019 - 2020/07 Anti-inflammatory and antioxidant activities exerted by phenolic compounds from Corema album (Licenciatura)
Co-supervisor
2016 - 2020/05 Fetal Programming of Hypertension: interplay between vascular sympathetic nerves, renin-angiotensin system and oxidative stress (Doutoramento)
Co-supervisor
Universidad Autónoma de Madrid Facultad de Medicina, Spain
2019 - 2019 Exploring the possibilities to increase the cytotoxicity of metal-polyamine complexes against breast cancer (Mobilidade - ERASMUS)
Supervisor
2019 - 2019 Anti-migratory properties of metal-polyamine complexes and antioxidants in breast cancer in vitro models (Mobilidade - ERASMUS)
Supervisor
2018 - 2019 Polyphenols and antihipertensive drugs in the metastatic process (Mobilidade - ERASMUS)
Supervisor
2018 - 2018 Bio-distribution and pharmacokinetics of novel metal drug for breast cancer - a non-clinical drug study in animal tissues (Mobilidade - ERASMUS)
Supervisor
2018 - 2018 Evaluation of anti-metastatic potential of metal-spermine complexes (Mobilidade - ERASMUS)
Supervisor
2017 - 2018 Adenosine Receptors and the Nuclear Membrane in Vascular Tissues (Mestrado)
Co-supervisor
 mestrado em bioquímica (Master)
2017 - 2018 Expression of angiotensin II AT2 receptor in the colon of TNBS-treated rats (Investigação-Projecto I, Mestrado Integrado em Ciências Farmacêuticas)
Co-supervisor
2017 - 2018 Influência do género na distribuição dos recetores dos sistema renina-angiotensins na hipertensão induzida por restrição alimentar materna (Investigação-Projecto I, Mestrado Integrado em Ciências Farmacêuticas)
Supervisor
2016 - 2017 Perfil de distribuição dos receptores do sistema renina-angiotensina num modelo experimental de hipertensão induzida por restrição alimentar materna (Mobilidade - ERASMUS)
Supervisor
2015 - 2017 Avaliação da alterações do ritmo circadiano e a sua relação com fatores de organização temporal do trabalho (Doutoramento)
Co-supervisor
2016 - 2016 Adenosine receptors location in vascular tissues from normotensive and hypertensive rodents (Mobilidade - ERASMUS)
Supervisor
2015 - 2016 Perfil de distribuição cardíaca dos recetores do sistema renina-angiotensina (SRA) num modelo exoerimental de hipertensão induzido por restrição maternal calórica (Investigação-Projecto I, Mestrado Integrado em Ciências Farmacêuticas)
Supervisor
2015 - 2015 Implicación del estrés oxidativo en las alteraciones cardiovasculares asociadas a la programación fetal de la hipertensión arterial (Doutoramento)
Co-supervisor
2014 - 2015 Perfil de distribuição e quantificação dos recetores de adenosina em vasos mesentéricos (Investigação-Projecto I, Mestrado Integrado em Ciências Farmacêuticas)
Supervisor
2014 - 2015 Transportadores equilibrativos de adenosina: Caracterização da sua distribuição e quantificação em vasos mesentéricos (Investigação-Projecto I, Mestrado Integrado em Ciências Farmacêuticas)
Supervisor
2013 - 2014 Anti-Angiogenic Properties of a Palladium Derivative Compound, the Pd2-Spm (Investigação-Projecto I, Mestrado Integrado em Ciências Farmacêuticas)
Supervisor
2013 - 2014 Distribuição de recetores A2A da adenosina no rim de rato hipertenso diabético (Investigação-Projecto I, Mestrado Integrado em Ciências Farmacêuticas)
Co-supervisor
2009 - 2014 New Perspectives on Melanoma Therapy: Insights on the Role of Adenosine and Adenosine Receptors (Doutoramento)
Co-supervisor of Ana Sofia Falcato Soares
Universidade do Porto Faculdade de Farmácia, Portugal
2009 - 2014 Adenosine receptors in vascular sympathetic neurotransmission: The role of endothelium and of nitric oxide-mediated effects and their relation with hypertension (Doutoramento)
Supervisor of Joana Beatriz Alves da Silva Pinheiro de Sousa
Universidade do Porto Faculdade de Farmácia, Portugal
2012 - 2013 Efeito da Diabetes na localização de recetores de adenosina no rim de ratos hipertensos (Investigação-Projecto I, Mestrado Integrado em Ciências Farmacêuticas)
Co-supervisor
2012 - 2013 Distribuição de recetores de adenosina no rim de rato hipertenso diabético: efeito do tratamento in vivo com um agonista ou com um antagonista desses recetores (Investigação-Projecto I, Mestrado Integrado em Ciências Farmacêuticas)
Co-supervisor
2007 - 2013 Functional and morphological characterization of vascular presynaptic adenosine receptors in spontaneously hypertensive rats (Doutoramento)
Supervisor of Maria Carolina Rocha e Pinho Pereira Meireles Amorim
Universidade do Porto Faculdade de Farmácia, Portugal
2010 - 2011 Osteoporose (Mestrado)
Supervisor
2010 - 2010 Distribution of adenosine transporters in the rat tail artery of Wistar Kyoto and Spontaneously Hypertensive Rats (Mestrado)
Co-supervisor
2008 - 2009 Actividade Biológica de Derivados do Ácido Cafeico: Efeito Antioxidante e Anti-inflamatório (Mestrado)
Supervisor of Joana Beatriz Alves da Silva Pinheiro de Sousa
Universidade do Porto Faculdade de Farmácia, Portugal
2008 - 2009 Adenosine transporters distribution pattern characterization in cardiovascular tissues from normotensive and hypertensive rats
Supervisor
2008 - 2008 Putative Role of Adenosine A2A Receptors In Inflammatory Processes (Mobilidade - ERASMUS)
Co-supervisor
2007 - 2007 Imunohistochemical characterization of adenosine A1 receptors in vessels from spontaneously hypertensive rats (Mobilidade - ERASMUS)
Supervisor
2006 - 2007 Protective role of adenosine in inflamatory processes: development of new therapeutic strategies- analysis of the anti-inflamatory activities of adensoine and xanthine derivatives on macrophages Raw 246.7 cells (Mobilidade - ERASMUS)
Co-supervisor
2005 - 2007 Papel Protector da Adenosina nos Processos Inflamatórios: Desenvolvimento de Novas Estratégias Terapêuticas
Co-supervisor
2002 - 2006 Caracterização Imuno-Histoquímica da Distribuição de Receptores da Adenosina no Sistema Cardiovascular em Ratos Normais e Hipertensos (Doutoramento)
Supervisor of Sandra Carla Ferreira Leal
Universidade do Porto Faculdade de Farmácia, Portugal
2004 - 2005 Interacção entre os receptores moduladores da libertação de noradrenalina, receptores A2A da adenosina e receptores alfa2 adrenérgicos na artéria da cauda de Rato (Mobilidade - ERASMUS)
Co-supervisor
2003 - 2004 Caracterização imuno-histoquímica e funcional da distribuição de receptores de adenosina no sistema cardiovascular em ratos normais e hipertensos (Investigação prégraduada)
Co-supervisor
2003 - 2004 Caracterização imuno-histoquímica e funcional da distribuição de receptores de adenosina no sistema cardiovascular em ratos normais e hipertensos (Investigação prégraduada)
Co-supervisor

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/02/06 - 2019/02/08 XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVII REUNIÃO FARMACOLOGIA CLÍNICA, XVIII REUNIÃO TOXICOLOGIA (2019/02/06 - 2019/02/08)
Congress (Member of the Organising Committee)
2017/02/11 - 2017/02/11 Seminário ROLE OF PREGNANCY AND PERINATAL LIFE ON CARDIOVASCULAR DISEASE PROGRAMMING (2017/02/11 - 2017/02/11)
Seminar (President of the Organising Committee)
 Universidade do Porto, Faculdade de Farmácia, Portugal
2013 - 2013 Seminário Fetal and Perinatal Programming of Cardiovascular Disease, Conferências, Seminários e Cursos na FFUP, JAN 11, 2013 (2013/01/11 - 2013/01/11)
Seminar (President of the Organising Committee)
 Universidade do Porto, Faculdade de Farmácia, Portugal
2010/09/08 - 2010/09/10 VI Congresso Ibérico de Espectroscopia, XXII Reunion Nacional de Espectroscopia, SEP 8-10, 2010. (2010/09/08 - 2010/09/10)
Congress (Member of the Organising Committee)
2010/05/28 - 2010/05/28 Workshop em Farmacologia, Conferências, Seminários e Cursos na FFUP, MAI 28 – JUN 4, 2010 (2010/05/28 - 2010/05/28)
Workshop (Member of the Organising Committee)
 Universidade do Porto, Faculdade de Farmácia, Portugal
2008/11/11 - 2008/11/12 II Congresso Científico da AEFFUP-Abordagens terapêuticas em Saúde Mental, Psicoses, Ansiedade e Depressão, NOV 11-12, 2008 (2008/11/11 - 2008/11/12)
Congress (Member of the Scientific Committee)
2006 - 2007 1th First Iberic Meeting of Medicinal Chemistry-Anticancer Agents, 28 Abril - 1 de Maio de 2007 (2007/04/28 - 2007/05/01)
Congress (Member of the Organising Committee)
2003 - 2004 4th Congress of the Federation of the European Pharmacological Societies (EPHAR 2004), JUL 14-17, 2004. (2004/07/14 - 2004/07/17)
Congress (Member of the Organising Committee)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2016 Doutoramento
(Thesis) Arguer
 Pilar Rodriguez Rodriguez (PhD)
2016 Mestrado Ciências Farmacêuticas (Presidente do júri)
President of the jury
 Ana Isabel Sousa Oliveira (Master)
2016 Mestrado em Bioquímica
(Thesis) Arguer
 João Oliveira Maia (Master)
2016 Mestrado em Ciências Farmacêuticas (Orientador e vogal)
Thesis Member
 Teresa Gomes (Master)
2015 Doutoramento em Química (Arguente principal)
(Thesis) Main arguer
 Inês Lamego (PhD)
2015 Mestrado em Ciências Farmacêuticas (Presidente do júri)
President of the jury
 Francisco Moreira e Costa (Master)
2015 Doutoramento em Segurança e Saúde Ocupacionais (Arguente)
(Thesis) Arguer
 Joana Cristina Cardoso Guedes (PhD)
2014 Doutoramento em Ciências Farmacêuticas (Orientador e vogal)
Thesis Member
 Joana Beatriz Alves da Silva Pinheiro de Sousa (PhD)
2013 Doutoramento em Ciências Farmacêuticas (Orientador e vogal)
Thesis Member
 Maria Carolina Rocha e Pinho Pereira Meireles Amorim (PhD)
2013 Doutoramento em Bioquímica (Arguente)
(Thesis) Arguer
 Tânia Raquel de Magalhães e Silva. (PhD)
2013 Mestrado em Ciências Farmacêuticas (Arguente)
(Thesis) Arguer
 Sérgio Rafael Teixeira Neves (Master)
2013 Mestrado em Ciências Farmacêuticas (Arguente)
(Thesis) Arguer
 Tânia Faria Coelho (Master)
2013 Mestrado em Ciências Farmacêuticas (Arguente)
(Thesis) Arguer
 Ana Rita Barbosa Magalhães Ferreira (Master)
2013 Mestrado em Ciências Farmacêuticas (Arguente)
(Thesis) Arguer
 Luísa Margarida da Fonte Senra (Master)
2012 Doutoramento em Tecnologia Farmacêutica (Arguente)
(Thesis) Arguer
 Jucimary Vieira dos Santos (PhD)
Universidade de Coimbra, Portugal
2012 Mestrado em Terapias Moleculares (Arguente)
(Thesis) Arguer
 Catarina Raquel Marques Baldaia Moreira (Master)
2010 Mestrado (Arguente)
(Thesis) Main arguer
 Luis António Abrantes Paulico (Master)
Universidade de Coimbra, Portugal
2008 Doutoramento em Farmacologia (Vogal)
Thesis Member
 Sandra Carla Ferreira Leal (PhD)
Universidade do Porto, Faculdade de Farmácia, Portugal
2004 Doutoramento em Farmacologia (Vogal)
Thesis Member
 Hélder José Marques Pinheiro (PhD)
Universidade do Porto, Faculdade de Farmácia, Portugal

Consulting

Activity description Institution / Organization
2012 - 2013 Consultoria e Parecer sobre a actividade de um fármaco para a empresa HOVIONE

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2016 - Current Métodos de Farmacologia in vitro (Programa Doutoral em Farmacologia e Toxicologia Experimentais e Clinicas) Farmacologia e Toxicologia Experimentais e Clínicas (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2014 - Current Alvos Terapêuticos na Doença Vascular (Mestrado Integrado em Ciências Farmacêuticas) Ciências Farmacêuticas (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2010 - Current Seminários Multidisciplinares (Programa Doutoral em Segurança e Saúde Ocupacionais) Segurança e Saúde Ocupacionais (Doutoramento) Universidade do Porto Faculdade de Farmácia, Portugal
2008 - Current Anatomia e Histologia (Mestrado Integrado em Ciências Farmacêuticas) Ciências Farmacêuticas (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2020/07/27 - 2020/10/23 Escola de Verão: Dieta, imunidade e inflamação (Outros) REQUIMTE LAQV Porto, Portugal

Universidade do Porto, Faculdade de Farmácia, Portugal
2019 - 2019 Fisiopatologia e Farmacoterapia II (Mestrado Integrado em Ciências Farmacêuticas) Ciências Farmacêuticas (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2015 Farmacologia II (Mestrado Integrado em Ciências Farmacêuticas) Ciências Farmacêuticas (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2007 - 2007 Farmacologia I (Licenciatura em Ciências Farmacêuticas ) Ciências Farmacêuticas (Licenciatura) Universidade do Porto Faculdade de Farmácia, Portugal
2004 - 2007 Anatomia e Histologia (Licenciatura em Ciências Farmacêuticas) Ciências Farmacêuticas (Licenciatura) Universidade do Porto Faculdade de Farmácia, Portugal
2006 - 2006 Cuidados Farmacêuticos no Idoso (Curso de Pós-graduação) Curso de Pós-graduação de Especialização em Cuidados Farmacêuticos (Especialização pós-licenciatura) Universidade do Porto, Faculdade de Farmácia, Portugal
2006 - 2006 Cuidados Farmacêuticos em Doentes com HIV e Tuberculose (Curso de Pós-graduação) Curso de Pós-graduação de Especialização em Cuidados Farmacêuticos Universidade do Porto, Faculdade de Farmácia, Portugal
2004 - 2006 Controlo Biológico e Toxicológico (Mestrado em Controlo de Qualidade) Mestrado em Controlo de Qualidade (Mestrado) Universidade do Porto, Faculdade de Farmácia, Portugal
2004 - 2006 Fisiologia (Licenciatura em Ciências Farmacêuticas) Ciências Farmacêuticas (Licenciatura) Universidade do Porto, Faculdade de Farmácia, Portugal
2003 - 2004 Histologia Humana (Licenciatura em Ciências Farmacêuticas) Ciências Farmacêuticas (Licenciatura) Universidade do Porto Faculdade de Farmácia, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021 - 2021 Agence Nationale de la Recherche Medical Research Council (MRC)- Avaliation Comitte
Evaluator
2012 - 2016 ROMANIAN NATIONAL RESEARCH COUNCIL
Evaluator
2010 - 2010 Projetos pluridisciplinares UPorto: Ciências da Saúde-neurofarmacologia
Evaluator
2010 - 2010 Projetos pluridisciplinares UPorto: Ciências da Saúde-neurofarmacologia
Evaluator
2010 - 2010 Projetos pluridisciplinares UPorto: Fisiologia Cardiovascular
Evaluator
2009 - 2009 Projetos pluridisciplinares UPorto 2009
Evaluator
2008 - 2008 HUNGARIAN SCIENTIFIC RESEARCH FUND (OTKA)
Evaluator

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current Cancers
2021 - Current Pharmaceuticals
2021 - Current Cell
2020 - Current Applied Sciences
2020 - Current The FEBS journal
2020 - Current RSC Advances
2019 - Current Biomolecules
2019 - Current Journal of the Renin-Angiotensin-Aldosterone System
2018 - Current Gene (0378-1119) Elsevier
2018 - Current Food & Function (2042-650X) The Royal Society of Chemistry
2018 - Current Cardiovascular Research
2017 - Current International Journal of Molecular Sciences (1422-0067) MDPI AG
2017 - Current Computers & Education (0360-1315) Elsevier
2016 - Current Molecules (1420-3049) MDPI AG
2014 - Current PLoS ONE (1932-6203) Public Library of Science
2012 - Current Letters in Drug Design & Discovery (1570-1808) Bentham Science
2012 - Current Drug Development and Industrial Pharmacy (1520-5762) Informa UK (Taylor & Francis)
2007 - Current Computer Methods and Programs in Biomedicine (0169-2607) Elsevier
2010 - 2014 Nature Products Research
2008 - 2008 Pharmacological Reports (2299-5684) Springer-Verlag
2007 - 2007 British Journal of Pharmacology (1476-5381) Wiley (Blackwell Publishing)
Distinctions

Award

2023 Best Oral communication
I Congresso Iberoamericano de Ciências Farmacêuticas, Portugal
2013 Best Poster
YES Meeting, Portugal
2009 Best poster -
14th Annual Meeting of the European-Council-for-Cardiovascular-Research. , France
2009 Best poster
1as Jornadas Científicas de Farmácia Comunitária., Portugal
2007 Best poster
II Simpósio Lusófono de Cuidados Farmacêuticos., Portugal