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Maria Teresa Cruz (MT Cruz) holds a degree in Pharmaceutical Sciences (1991) from the University of Lisbon, a master's in Drug Technologies (1996), and a PhD in Pharmacology (2004) at UC. She is associate professor with Habilitation at the Faculty of Pharmacy, Group Leader at the Centre for Innovative Biomedicine and Biotechnology, and Principal Investigator of the Innate Immunity in inflammation-related diseases research line within the CNC Cell Signaling and Metabolism in Disease group. She holds the European Registered Toxicologist title, awarded by EUROTOX (Federation of European Toxicologists and European Societies of Toxicology) since 2018 and European Certified Pharmacologist title, awarded by EPHAR (Federation of European Pharmacological Societies) since 2024. MT Cruz has actively participated in numerous national and international funded projects (49 projects), with 21 of them under her responsibility, including those funded by the European Union 7th Framework Programme, John Hopkins, Cosmetics Europe, Lierac, and Vichy. She has contributed to 7 international patents and filed 5 provisional patent requests, authored 6 book chapters, and published 208 articles in SCI indexed journals. Included in the "World's Top 2% Scientists" concerning the most cited researchers in 2022 and 2023, MT Cruz boasts an h-index of 40 with 8158 citations, as per the Web of Science. She has supervised or co-supervised 21 doctoral (9 completed dissertations), 33 master (25 completed dissertations), and 3 post-doctoral students. MT Cruz regularly reviews R&D projects for various institutions, including ERA4Health, Netherlands Organisation for Scientific Research, French National Research Agency, Alzheimer's Association Research Fellowship Program, External Expert for COST proposals evaluation, among others. In terms of knowledge transfer and valorization, MT Cruz has played a pivotal role in creating a spin-off from the UC, Toxfinder, which has received several entrepreneurship awards and has been actively involved in patents and providing specialized services to national and international entities. Furthermore, MT Cruz contributed to the design and establishment of a Pilot Production Unit for Cell Therapy, the UpCells laboratory, resulting from a partnership between UC and the pharmaceutical industry Tecnimede, meeting all the requirements for the preparation and handling of cellular products for clinical application according to GMP. Given her expertise in Innovation and Entrepreneurship, MT Cruz was invited by the UC Rectorate to participate in the "Together for the Future of the UC" event, a crucial component of UC's Strategic Planning 2023-2027. She was invited to join the Acelera@UC mentoring team, organized by UC Business - Technology Transfer Office, aimed at guiding entrepreneurs in creating commercially viable, successful, and sustainable businesses. During the SARS-CoV-2 pandemic, MT Cruz played a pivotal role as part of the coordination team at the University of Coimbra, overseeing diagnostic testing for Covid-19. She adapted laboratory facilities, conducted diagnostic tests, and trained nine teams of volunteers, totaling approximately 80 individuals. In terms of pedagogical activity, MT Cruz teaches various curricular units at the Faculty of Pharmacy, covering subjects such as Pharmacology, Histology and Human Embryology, Cell Biology, Molecular Biology, Immunology, Pathophysiology, Anatomy and Human Physiology, Pre-Clinical Drug Development, and Pharmacological Screening. She has also contributed to several master's and doctoral programs at the University of Coimbra and other institutions.
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Identification

Personal identification

Full name
Maria Teresa Cruz

Citation names

  • Cruz, Maria Teresa
  • Cruz MT
  • Cruz T

Author identifiers

Ciência ID
6111-F90A-3CE1
ORCID iD
0000-0001-9846-6754
Google Scholar ID
http://scholar.google.com/citations?user=sFivkSoAAAAJ
Researcher Id
F-5288-2013
Scopus Author Id
7201363895

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Beginner (A1) Advanced (C1) Intermediate (B1) Beginner (A1)
Education
Degree Classification
2024/07/11 - 2024/07/11
Concluded
 Ciências Farmacêuticas, na especialidade de Farmacologia e Farmacoterapia (Título de Agregado)
Universidade de Coimbra, Portugal
2004/06/17
Concluded
 Doutoramento em Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
 Aprovado por unanimidade com distinção e louvor
2004
Concluded
 Farmácia (Doutoramento)
Major in Especialidade: Farmacologia
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Vias de Sinalização Intracelular Envolvidas na Expressão da Isoforma Indutível da Sintase do No: Efeito do Lipopolissacarídeo, Citocinas e Alergénios em Células Dentríticas da Pele" (THESIS/DISSERTATION)
1996
Concluded
 Mestrado em Tecnologias do Medicamento (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
 Muito Bom
1992
Concluded
 Ciências Farmacêuticas (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 17 valores
Affiliation

Science

Category
Host institution 		Employer
1996/10/07 - Current Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2022/04/01 - Current Associate Professor (University Teacher) Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2004/06/18 - Current Assistant Professor (University Teacher) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Hospitais da Universidade de Coimbra, Portugal
1996/10/08 - 2004/06/17 Assistant (University Teacher) Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal

Other Careers

Category
Host institution 		Employer
1993/04/26 - 1993/10/11 Técnico Superior (Técnico Superior) Hospital Infante Dom Pedro-Aveiro, Portugal
Hospital Infante Dom Pedro-Aveiro, Portugal
1992/04/01 - 1992/04/26 Técnico Superior (Técnico Superior) Hospital Curry Cabral, Portugal

Others

Category
Host institution 		Employer
2011/09/01 - Current Sócio fundador da Spin off da Universidade de Coimbra Toxfinder Lda, Portugal
Toxfinder Lda, Portugal
Projects

Grant

Designation Funders
2019 - Current Circadian rhythm disruption in Bipolar disorder: from molecular mechanisms to novel therapeutic targets
SFRH/BD/148653/2019
SFRH/BD/148653/2019
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
2016 - Current Estágio de investigação no Departamento de Microbiologia e Imunologia, na UNESP, Campus de Botucatu, Brasil,
ESTÁGIO INVESTIGAÇÃO
Invited Scientist Fellow
Fundação para o Desenvolvimento da UNESP, Brazil
2013 - Current estágio de investigação no Departamento de Microbiologia e Imunologia, na UNESP, Campus de Botucatu, Brasil
estágio de investigação no Departamento de Microbiologia e Imunologia, na UNESP
Invited Scientist Fellow
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil
Concluded
2011/01/01 - Current IN VITRO CELLULAR APPROACH FOR SKIN SENSITIZATION HAZARD: AN EU LEGISLATION DEMAND
SFRH/BD/73065/2010
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/06/30 - 2022/05/31 Characterization of phytochemical components of Eucalyptus globulus leaves and their pharmacological potentials: a multi-functional insight.
InPaCTus” COMPETE2020 nº 21874
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ongoing
2018/06/30 - 2022/05/31 Development of a Medical Device for prevention of Allergic Contact Dermatitis
PD/BDE/142926/2018
PD/BDE/142926/2018
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2021/01/22 - 2021/11/16 TECNICOV: Development of rapid testes for antibody anti-SARS-CoV-2 monitorization in serum and saliva.
POCI-01-02B7-FEDER-069745
 Fundação para a Ciência e a Tecnologia
Concluded
2017/03/01 - 2021/02/28 Desenvolvimento de plataformas baseadas em células dendriticas para screening toxicológico e farmacológico
PD/BDE/135076/2017
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/04/01 - 2020/03/30 “Desenvolvimento de uma plataforma in-vitro/in chemico para a identificação de alergénios respiratórios
SFRH/BD/110717/2015
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2012/01/01 - 2016/12/31 ELECTROPHILIC STRESS: MOLECULAR TARGETS FOR SKIN SENSITIZERS
SFRH/BPD/90378/2012
Supervisor
Universidade de Aveiro, Portugal
Concluded
2014/06/01 - 2015/12/31 ToxVitroTesting”.
Quadro de Referência Estratégico Nacional (QREN) – Empresas em co-promoção project ref: 38977, 2014
Supervisor
Toxfinder Lda, Portugal
Concluded
2011/01/01 - 2014/12/31 FRAGARIA VESCA LEAF AS A SOURCE OF BIOACTIVE PHYTOCHEMICALS - A FOCUS ON ELLAGITANNINS AND THEIR HUMAN MICROFLORA METABOLITES
SFRH/BD/72918/2010
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/10/01 - 2012/12/31 Cellular and Molecular Mechanisms of Impaired Wound Healing in Diabetes: Understanding the Role of Substance P and Mast Cells
SFRH/BD/48624/2008
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012/12/31 Anti-inflammatory mechanism and properties of plants used in traditional medicine: evaluation of their potential use as source for new anti-inflammatory drugs
SFRH/BD/46281/2008
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/01/01 - 2010/12/31 Identification of cellular and molecular markers selectively activated by skin sensitizers in dendritic cells
SFRH/BD/30563/2006
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1996/01/01 - 1996/05/31 Vias de sinalização intracelular envolvidas na expressão da isoforma indutível da sintase do NO: efeito do lipopolissacarídeo, citocinas e alergénios em células dendríticas da pele
BD/5176/95
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1993/10/01 - 1995/09/30 Mestrado em Tecnologias do Medicamento
BM/2363/93
Master Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2020 - Current Impacto da ação de produtos naturais sobre células envolvidas na imunidade e em células tumorais humanas
CAPES-PRINT-UNESP – EDITAL 02/2019
CONVÊNIO CAPES-PRINT-UNESP – EDITAL 02/2019, REDES DE PESQUISA INTERNACIONAIS
CONVÊNIO CAPES-PRINT-UNESP EDITAL 02/2019, REDES DE PESQUISA INTERNACIONAIS
CAPES-PRINT-UNESP EDITAL 02/2019
Invited Scientist Fellow
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil
 N/A
Ongoing
2018/07/22 - Current PulManCar: Microparticles design for active compounds pulmonary delivery using insulin as model
POCI-01-0145-FEDER-029560
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
2017/09/01 - Current ImmunoDCs@CancerStemCells: Imunoterapia celular direcionada para a eliminação de células estaminais cancerígenas
033532
Researcher
Universidade de Coimbra, Portugal
Ongoing
2017 - Current IBERPHENOL: Red cooperativa de investigación en el ámbito de polifenoles y sus aplicaciones industriales
, project EP - INTERREG V A España Portugal (POCTEP)
, project EP - INTERREG V A España Portugal (POCTEP)
Researcher
Universidade de Coimbra Faculdade de Farmácia, Portugal
 N/A
Ongoing
2017 - Current HealthyAging2020
CENTRO-01-0145-FEDER-000012-2017-2020
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2017 - Current InPaCTus”, Centro de Excelência, PORTUGAL2020, projeto co-promoção "The Navigator Company"-RAIZ-Univ. Coimbra-Univ. Aveiro (sub-projeto “Extractos de valor acrescentado de biomassa floresta
portugal 2020
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ongoing
2021/01/01 - 2025/12/31 Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado
LA/P/0058/2020
10.54499/LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/12 - 2024/09/11 Epigenetic modulation of blood-brain barrier integrity for the prevention of epileptogenesis
2022.03133.PTDC
10.54499/2022.03133.PTDC
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/09/01 - 2024/03/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/10 - 2022/10 "Impact of the action of natural products on human innate immune and tumor cells."
# 88887.194785/2018-00
Researcher
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Instituto de Biociências, Brazil
 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Ongoing
2018/06/22 - 2022/04/21 Development of a Novel Nose-to-Brain multifunctional nanoplatform for the treatment of Depression and prevention of pharmacoresistance development
PTDC/SAU-SER/30752/2017
CENTRO-01-0145-FEDER-030752
Researcher
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia

Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2018/09 - 2021/09/16 Vesículas extracelulares de Giardia lamblia na imunomodulação de células do hospedeiro: potencial aplicação terapêutica das EVs de Giardia na inflamação intestinal
PTDC/SAU-PAR/31506/2017
PTDC/SAU-PAR/31506/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT

Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/27 - 2021/07/25 The ups and downs of cellular stress: the “MAM hypothesis” for Bipolar disorder pathophysiology
CENTRO-01-0145-FEDER-028214
PTDC/MED-NEU/28214/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT

Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/26 - 2021/07/25 Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease
PTDC/MED-FAR/29369/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/15 - 2021/07/14 Hepatitis B therapeutic vaccine: Production of glucan-based nanoparticles towards selective delivery hepatitis B antigens to immune cells to induce antiviral activity.
PTDC/MEC-GAS/30331/2017
POCI-01-0145-FEDER-030331
POCI-01-0145-FEDER-030331
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia

Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2018/07/28 - 2021/06/30 Allergens4AD-Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease
POCI-01-0145-FEDER-029369
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/06/30 Microparticles design for active compounds pulmonary delivery using insulin as model
PTDC/EQU-EPQ/29560/2017
Universidade de Aveiro, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/02/02 - 2021 Optimization of a defined approach for skin sensitizer potency integrating in silico, in chemico and in vitro cell data for classifying chemicals accordingly to five categories (extreme, strong, moderate, weak and non-sensitizer).
Cosmetics Europe
Principal investigator
Cosmetics Europe, Belgium
Ongoing
2017 - 2018 Valorization of the Thermal resorts of the Centre Region - Characterization of the bioactive potential of the thermal water resources of the Region - "Study of the therapeutic properties of thermal waters - dermocosmetic"
CENTRO-04-3928-FEDER-000010
CENTRO-04-3928-FEDER-000010
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 N/A
Concluded
2015 - 2017 Própolis: “Modulation of antigenic presentation and differential activation of T lymphocytes”.
2015/03493-3
Researcher
Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2014 - 2015 Development and validation of a pilot laboratory for cell therapy (UpCells)
5378/2014
5378/2014
Researcher
N/A
Concluded
2014 - 2015 Exosomes: putative biomarkers for respiratory and cutaneous allergens hazard
PRIME-XS project, grant agreement number 262067
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2014 - 2015 ToxVitroTesting
38977
Principal investigator
Toxfinder Lda, Portugal
Concluded
2014 - 2015 Generation of a novel dendritic cell-based vaccine against glioblastoma
INOVC
Principal investigator
Concluded
2013 - 2015 In chemico, in silico and in vitro dendritic cell modeling to predict human respiratory allergens
John Hopkins 2013
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2010/05/01 - 2013/10/31 Anti-inflammatory mechanism and properties of medicinal plants: a multidisciplinary research for their validation and utilization as a source of phytopharmaceuticals
PTDC/SAU-FCF/105429/2008
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/105429/PT
Researcher
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Estudos Farmacêuticos, Portugal

Universidade de Aveiro, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia

Associação para a Inovação e Desenvolvimento da FCT
Concluded
2010/04/01 - 2013/09/30 Implication of sirtuin proteins in the regulation of antigen presenting cells apoptosis during leishmaniasis: a therapeutic approach
PTDC/SAU-FCF/100749/2008
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia

Associação para a Inovação e Desenvolvimento da FCT
Concluded
2010/04/01 - 2013/09/30 In vitro alternative approach for chemical skin sensitization hazard: an EU legislation demand
PTDC/SAU-OSM/099762/2008
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/99762/PT
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia

Associação para a Inovação e Desenvolvimento da FCT
Concluded
2010/04/01 - 2013/09/30 Role and mechanism of action of immunoregulatory iNKT and DC cells in Leishmania infection: new approaches for vaccination?
PTDC/SAU-FCF/101017/2008
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/101017/PT
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia

Associação para a Inovação e Desenvolvimento da FCT
Concluded
2011 - 2013 Phenolic compounds of cork: cosmetic validation, alimentary evaluation and nutraceutic potential – NutraCork
21597/2011
Researcher
Concluded
2009/01/05 - 2012/10/04 Whole human genome analysis of genetic imbalances and numerical abnormalities by single-nucleotide polymorphism (SNP)-arrays in gliomas: correlation with clinical and biological features of the disease.
PIC/IC/83108/2007
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Hospitais da Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2011 Extraction and isolation of compounds with high biological potential from by-products of the cork industry – BioactiveCork
5455/2009
Researcher
Concluded
2008 - 2010 Dissecting the molecular mechanisms of wound healing in diabetes - the role of neuropeptides
PTDC/SAU-MII/098567/2008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2007/08/16 - 2009/12/31 ROLE OF DENDRITIC CELLS IN LEISHMANIASIS: intracellular signalling pathways activated by virulent and attenuated parasite Leismania infantum
PTDC/SAU-FCF/67351/2006
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008 - 2009 Cellular and molecular mechanisms of dendritic cells activation by skin sensitizers and irritants
Lierac, grupo Alés, Paris
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2007 - 2008 Identificação de marcadores celulares activados selectivamente por alergénios de contacto em células dendríticas
17/07
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra Faculdade de Medicina
Concluded
2006 - 2008 Papel das Células dendríticas na Leishmaniose: estudos de sinalização intracelular na infecção pelo parasita Leishmania infantum virulento ou atenuado
PTDC/SAU-FCF/67351/2006
PTDC/SAU-FCF/67351/2006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2006 - 2008 Intracellular Signaling pathways involved on the expression of proteins related to the glioblastoma cells progression
CIMAGO, 10/06
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia
Concluded
2006 - 2007 Activação de vias de sinalização intracelular em células dendríticas: acção de fármacos imunossupressores
12/06
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra Faculdade de Medicina
Concluded
2001/01/15 - 2003 Early Cellular Events Induced by Different Sensitizing Chemicals in Skin Derived Dendritic Antigen Presenting Cells
info:eu-repo/grantAgreement/FCT/POCI/36373/PT
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
1996 - 1998 Intracellular signaling pathways activated by cytokines and allergens in antigen presenting cells
PRAXIS/PSAU/P/SAU/126/96
PRAXIS/PSAU/P/SAU/126/96
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
1995 - 1997 Mecanismos de morte celular durante a terapia fotodinâmica em células excitáveis
PRAXIS XXI/SAU/1198/95
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
1995/12/01 - 1996/04/30 MECANISMOS DE MORTE CELULAR DURANTE A TERAPIA FOTODINÂMICA DAS CÉLULAS EXCITÁVEIS
PRAXIS XXI/BD/5176/95
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2013 - 2014 How does autophagy modulate inflammasome activation?
GAI 2014_2
Universidade de Coimbra Faculdade de Medicina, Portugal
 Universidade de Coimbra Faculdade de Medicina
Concluded
Outputs

Publications

Book
  1. Mendes, Alexandrina Ferreira ; Cruz, Maria Teresa; Gualillo, O.. The Physiology of Inflammation – The Final Common Pathway to Disease. Frontiers Media SA. 2019.
    10.3389/978-2-88945-729-8
  2. Babo, Maria Augusta; Pinto, José Gomes; Cruz, Maria Teresa. Tecnologias culturais e Artes dos Media. Lisboa, Portugal: CECL/UnyLeya. 2016.
    Published
  3. Francisco, V.; Costa, G.; Neves, B.M.; Cruz, M.T.; Batista, M.T.. Anti-Inflammatory Activity of Polyphenols on Dendritic Cells. 2013.
    10.1016/B978-0-12-398456-2.00028-1
Book chapter
  1. Calmeiro, João; Carrascal, Mylene; Gomes, Célia; Falcão, Amílcar; Cruz, Maria Teresa; Neves, Bruno Miguel. "Highlighting the Role of DC-NK Cell Interplay in Immunobiology and Immunotherapy". In Dendritic Cells. InTech, 2018.
    10.5772/intechopen.78804
  2. Francisco, V.; Costa, G.; Neves, B.M.; Cruz, M.T.; Batista, M.T.. "Antiinflammatory activity of polyphenols on dendritic cells". 395-415. 2018.
  3. Neves, Bruno Miguel; Martins, João Demétrio; Ferreira, Isabel; Silva, Ana; Cruz, Maria Teresa. "In Vitro Dendritic Cell-Based Test for Skin Sensitizers Identification and Potency Estimation". In Alternatives for Dermal Toxicity Testing, 417-435. Springer International Publishing, 2017.
    10.1007/978-3-319-50353-0_29
  4. Cruz, Maria Teresa; Liberal, Joana; Ferreira, Isabel V.; Cardoso, Eliza O.; Silva, Ana; Bartolomeu, Ariane R.; Martins, Joao; et al. "Anti-Inflammatory Activity of the Honeybee Plant- Derived Products Honey, Pollen and Propolis". In Chemistry, Biology and Potential Applications of Honeybee Plant- Derived Products, 313-346. BENTHAM SCIENCE PUBLISHERS, 2016.
    10.2174/9781681082370116010012
  5. Francisco, V.; Costa, G.; Neves, B.M.; Cruz, M.T.; Batista, M.T.. "Anti-Inflammatory Activity of Polyphenols on Dendritic Cells". In Polyphenols in Human Health and Disease, 373-392. Elsevier, 2014.
    10.1016/b978-0-12-398456-2.00028-1
  6. Cruz, Maria Teresa. "Células dendríticas". In Fundamentos de Imunologia. lidel, 2012.
    Published
  7. Miguel, Bruno; Celeste, Maria; Teresa, Maria. "Pathogen Strategies to Evade Innate Immune Response: A Signaling Point of View". In Protein Kinases. InTech, 2012.
    10.5772/37771
Conference abstract
  1. Calmeiro J; Carrascal M; Mendes, LF; Duarte, Iola F; Gomes, Célia; Serra J; Falcão A; Cruz MT; Neves, Bruno. "Dendritic-cell based immunotherapy targeting pancreatic and NSCLC cancer stem cells". Paper presented in iTOCC7 - The 7th Leading International Cancer Immunotherapy Conference in Europe - Abstracts published in Journal for ImmunoTherapy of Cancer 8, Suppl2, A36, 2020.
  2. Alves-Silva, Jorge; Guerra, Inês; Gonçalves, Maria José; Cavaleiro, Carlos; Cruz, Maria Teresa; Figueirinha, Artur; Salgueiro, Lígia. "Chemical characterization of the hydrodistillation residual water and essential oil of Crithmum maritimum". Paper presented in 11º Encontro Nacional de Cromatografia, Lisboa, 2019.
    Published
  3. Oliveira, AS; Vaz, CV; Silva, A.; Correia, S.; Ferreira, R.; Breitenfeld, L.; Martinez-de-Oliveira, J.; et al. "Portuguese Thermal Waters: in vitro effect on microbial growth and skin cell regeneration". Paper presented in XIII Annual CICS-UBI Symposium, Covilhã, 2018.
    Published
  4. Alves-Silva, Jorge; Zuzarte, Mónica; Gonçalves, Maria José; Cavaleiro, Carlos; Cruz, Maria Teresa. "Óleos essenciais de Daucus carota: marcadores quimiotaxonómicos e agentes bioativos". Paper presented in V Congresso Ibérico de Apicultura 1-3 February 2018, Coimbra, 2018.
  5. Gonçalo, Margarida; Martins, João Demétrio; Neves, Bruno Miguel; Silva, Ana Cristina Rosa da; Figueiredo, Américo; Lopes, Maria Celeste; Cruz, Maria Teresa. "As contact sensitizers, drugs causing delayed drug erutpions activate THP-1 cells". Paper presented in 12th Congress of the European Society of Contact Dermatitis, Barcelona, 2014.
    Published
  6. Martins, J.; Neves, Bruno Miguel; Gonçalo, Margarida; Lopes, Maria Celeste; Domingues, M. R.; Cruz, Maria Teresa. "Role of extracelular danger signal adenosine-5’-triphosphate on the 1-fluoro-2,4-dinitrobenzene-induced maturation of THP-1 cells". Paper presented in 42nd Annual ESDR Meeting, Veneza, 2012.
    Published
  7. Neves, Bruno; Silvestre, Ricardo; Cunha, Joana; Tavares, Joana; Resende, Mariana; Ouaissi, Ali; Lopes, MC; Cruz, Maria Teresa; Cordeiro-da-Silva, Anabela. "Immunomodulation of dendritic cells by virulent and attenuated Leishmania infantum strains". Paper presented in 2nd European Congress of Immunology, Berlim, 2009.
    Published
  8. Neves, B.; Francisco, Vera; Cruz, Maria Teresa; Gonçalo, Margarida; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria Celeste. "Modulation of CXCR4 by skin sensitizers and irritants in dendritic cells.". Paper presented in 9th ESDC Congress, Estoril, 2008.
    Published
  9. Francisco, Vera; Neves, B.; Cruz, Maria Teresa; Gonçalo, Margarida; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria Celeste. "The sensitizer nickel increases thioredoxin in dendritic cells". Paper presented in 9th ESDC Congress, Estoril, 2008.
    Published
  10. Gonçalo, Margarida; Cruz, Maria Teresa; Duarte, Carlos B.; Figueiredo, Américo; Lopes, Maria Celeste. "Immunossupressive drugs in Ni-induced iNOS expression in skin DC". Paper presented in 8th ESCD Congress, Berlim, 2006.
    Published
  11. Cruz, Maria Teresa; Jaleco, S. P.; Duarte, Carlos B.; Gonçalo, Margarida; Figueiredo, Américo; Carvalho A. P.; Lopes, Maria Celeste. "Early cellular events induced by DNFB and DCNB in a fetal skin derived dendritic cell line.". Paper presented in 5th ESCD Congress, Amsterdam, 2000.
    Published
  12. Cruz, Maria Teresa; Gonçalo, Margarida; Duarte, Carlos B.; Carvalho A. P.; Lopes, C.. "A skin derived dendritic cell line produces nitric oxide after stimulation with LPS and GM-CSF.". Paper presented in 6th EADV Congress, Dublin, 1997.
    Published
  13. Cruz, Maria Teresa; Gonçalo, Margarida; Duarte, Carlos B.; Carvalho A. P.; Lopes, Maria Celeste. "Estudo da expressão da isoforma indutiva da sintase do óxido nitrico numa linha celular dendrítica isolada da pele do rato". Paper presented in 1º Congresso de Investigação em Medicina, Coimbra, 1997.
    Published
Conference poster
  1. Páscoa, Ricardo; Mota, Sandra; Torres, Ana; Joana Rocha e Silva; Agostinho Almeida; Helena N. Ferreira; Cruz, Maria Teresa; Isabel F. Almeida. Corresponding author: Isabel F. Almeida. "Unlocking the Potential of Cork Powder: Sustainable Sourcing for the Cosmetic Industry.". Paper presented in Cosmetinnov, 2024.
  2. Panão Costa, João; Colaço, Mariana; Félix, Paulo; Melo, Alexandra; Lebre, Filipa; Cruz, Maria Teresa; Alfaro-Moreno, Ernesto; Moreira, João Nuno; Borges, Olga. "ß-glucan polymeric microparticles: innovating cancer immunotherapy through targeted antigen delivery". Paper presented in 6th ASPIC International Congress, 2024.
  3. Gouveia, Filipa; Fonseca, Carla; Bicker, Joana; Camins, Antoni; Cruz, Maria Teresa; Ettcheto, Miren; Fortuna Ana. "Intranasal Administration of Irbesartan as a New Strategy for Addressing Neurodegeneration in a Neuroinflammation Mice Model: Pharmacokinetic and Efficacy Evaluation". Paper presented in Congresso do Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra, 2024.
  4. Sebastião, AI; Oliveira, Filomena; Simões, Gonçalo; Mateus, Daniela; Gomes, Célia; Neves, Bruno; Carrascal, Mylène A.; Cruz, Maria Teresa. Corresponding author: Cruz, Maria Teresa. "Dendritic cells loaded with cancer-testis antigens to halt triple-negative breast cancer". Paper presented in III ASPIC-ASEICA International Meeting, 2023.
  5. Gouveia, Filipa; Bicker, Joana; Carona, Andreia; Ettcheto, Miren; Cruz, Maria Teresa; Fortuna, Ana. "Ultra High Performance Liquid Chromatography Technique to support Pharmacokinetic Monitoring of Losartan, Irbesartan and Valsartan". Paper presented in X Congresso Iberoamericano de Ciências Farmacêuticas, 2023.
  6. Susano, Patrícia; Silva, Joana; Alves, Celso; Martins, Alice; Pinteus, Susete; Cruz, Maria Teresa; Gabig-Ciminska, Magdalena; Pedrosa, Rui. "Cytotoxic and anti-inflammatory effects of seaweed-derived compounds in human keratinocytes (HaCaT cells)". Paper presented in International Symposium on Marine Natural Products and European Conference on Marine Natural Products, 2023.
  7. Mota, Sandra; Silva, José Paulo ; Pinto, Cláudia; Torres, A; Rego, Liliana; Cravo, Sara; Afonso, Carlos; et al. "A tríade de sustentabilidade do Quercus Suber como fonte de ingredientes cosméticos: Longevidade, Regeneração e Upcycling". Paper presented in XXVI COLAMIQC 2023, 2023.
  8. Faria, Clarissa Perez; Ferreira, Bárbara; Ágata Lourenço; Mateus, Daniela; Sebastião, Ana Isabel; Neves, Bruno; Cruz, Maria Teresa; Maria do Céu Rodrigues de Sousa. Corresponding author: Maria do Céu Rodrigues de Sousa. "Extracellular Vesicles of Giardia lamblia modulate host cell innate immunity: new avenues for the exploitation of novel therapies". Paper presented in 33rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2023.
  9. Sebastião, AI; Oliveira, Filomena; Simões, Gonçalo; Mateus, Daniela; Gomes, Célia; Neves, Bruno; Carrascal, Mylène A.; Cruz, Maria Teresa. Corresponding author: Cruz, Maria Teresa. "Dendritic Cell-Loading Vaccine With Cancer-Testis Antigens To Halt Triple-Negative Breast Cancer Cell". Paper presented in XLVIII SPI Annual Meeting 2023, 2023.
  10. Ana Sofia Oliveira; Cátia Vaz; Carolina Proença Gomes; Rolo, Joana; Palmeira-de-Oliveira, Rita; Ana Silva; Cláudia Pereira; Cruz, Maria Teresa; Oliveira, Ana Cristina Palmeira de. "The potential of Portuguese Thermal Waters as cosmetic ingredients for fragilized skin with a focus on skin repairing activity". Paper presented in OncoSkin: I Congresso de Skincare, Estética e Dermocosmética em Oncologia, 2023.
  11. Mateus, Daniela; Sebastião, Ana Isabel; Carrascal, Mylène; Cortes, Luisa; Carmo, Anália; Matos, Ana Miguel; Maria Goreti Ferreira Sales; Cruz, Maria Teresa. Corresponding author: Cruz, Maria Teresa. ""SARS-CoV-2, Dendritic Cells, and Immunity: the connected dots"". Paper presented in BEB day, 2022.
  12. MoreiraP; Macedo, Jéssica; Figueirinha A; Salgueiro L; Batista MT; Silva S; Branco PC; Cruz MT; Pereira CF. "Protective effects of extracts from Eucalyptus globulus biomass in Alzheimer's disease in vitro and in vivo models. Beneficial effects of compounds extracted from Eucalyptus globulus biomass on skin health.". Paper presented in Iberoamerican Congress on Pulp and Paper Research (CIADICYP), Girona, 2022.
  13. Moreira, Patricia; Macedo, Jéssica; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Silva, Sónia; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Neuroprotective properties of extracts from Eucalyptus globulus biomass and its beneficial effects in an Alzheimer's disease mouse model". Paper presented in 16th International Conference on Alzheimer's & Parkinson's Diseases, Barcelona, Spain, 2022.
  14. Silva, Ana Cristina Rosa da; Pereira, Marta; Carrascal, Mylene; Brites, Gonçalo Sousa; Neves, Bruno; Moreira, Patricia; Resende, Rosa; et al. "EFFECT OF SKIN ALLERGENS TARGETING NRF2 TRANSCRIPTION FACTOR ACTIVATION ON ALZHEIMER’S DISEASE HALMARKS". Paper presented in 15th International Conference on Alzheimer's and Parkinson's Diseases (ADPD2021), 2021.
  15. Moreira, Patricia; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Silva, Sónia; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Effects of extracts from forestry biomass in Alzheimer's disease in vitro and in vivo models: interplay between bioeconomy and health benefits". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal, 2021.
  16. Moreira, Patricia; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Chemical composition and bioactivity of phenolic compounds extracted from Eucalyptus globulus biomass". Paper presented in IberPhenol - International Conference, Coimbra, Portugal, 2020.
  17. Calmeiro, João; Mylène Carrascal; Luis Mendes; Iola F. Duarte; Célia Gomes; João Serra; Amílcar Falcão; Cruz, Maria Teresa; Neves, Bruno. "Dendritic cell plasticity in cancer immunotherapy: functional and metabolic characterization of the impact of different GMP serum-free media in human-monocyte-derived DCs". Paper presented in 1st Meeting of the French Society of Cancer Immunotherapy, Institut Curie, Paris, France, 2019.
  18. Sousa, Fábio J.; Carrascal, Myléne A.; Moreira, Paula I.; Santos, Armanda E.; Cruz, Maria Teresa; Pereira, Cláudia. "Impact of Endoplasmic Reticulum stress on neuronal mitochondria". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, Coimbra, Portugal, 2019.
  19. Moreira, Patricia; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Antifungal activity and cytotoxicity evaluation of phenolic compounds extracted from Eucalyptus globulus biomass". Paper presented in Iberian Congress of Phenolic Compounds, Ourense, Spain, 2019.
  20. Silva, Ana; Pereira, Marta; Brites, Gonçalo; Neves, Bruno; Moreira, Patricia; Resende, Rosa; Silva, Maria Manuel; et al. "Skin allergens and Alzheimer´s disease: preliminary studies on an (im)probable link". Paper presented in Cell Signalingin Aging and Neurodegenerative Diseases, Coimbra, Portugal, 2019.
  21. Moreira, Patricia; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Determination of safe bioactive doses of essential oil and phenolic compounds extracted from Eucalyptus globulus leaves". Paper presented in Natural Products in Drug Discovery and Human Health (NatProdDDH) – PSE Meeting, Lisbon, Portugal, 2019.
  22. Calmeiro, João; Mylène Carrascal; Luis Mendes; Iola F. Duarte; Célia Gomes; João Serra; Amílcar Falcão; Cruz, Maria Teresa; Neves, Bruno. "Impact of different GMP serum-free media in the plasticity of dendritic cells for clinical use in cancer immunotherapy". Paper presented in 26th Porto Cancer Meeting & Porto-Bordeaux joint meeting: the cancer ecosystem, i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal, 2019.
  23. Calmeiro, João; Mylène Carrascal; Luis Mendes; Iola F. Duarte; Célia Gomes; João Serra; Amílcar Falcão; Cruz, Maria Teresa; Neves, Bruno. "Dendritic cells plasticity for clinical use in cancer immunotherapy: functional and metabolic characterization of the impact of different GMP serum-free media in monocyte-derived dendritic cells.". Paper presented in 5th Workshop on Dendritic Cell Biology: antitumoral immunotherapy, from biology to the clinic. Champalimaud Foundation, Lisbon, Portugal, 2019.
  24. Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Morais, S; Madeira, N; Cruz, Maria Teresa; Pereira, Cláudia. "Mitochondria-Associated Membranes: the putative link between cellular stress and inflammasome activation in Bipolar Disorder". Paper presented in Encontro Nacional da Sociedade Portuguesa de Psiquiatria e Saúde Mental (SPPSM)| II Encontro das Secções, 2019.
  25. Pereira, Marta; Silva, Ana; Neves, Bruno; Moreira, Patricia; Silva, Maria Manuel; Santos, Armanda Emanuela; Pereira, Cláudia Fragão; Cruz, Maria Teresa. "Molecules with an improbable therapeutic application for Alzheimer’s disease". Paper presented in Ageing: models, mechanisms and therapies, Coimbra, Portugal, 2019.
  26. Faria CP; Neves BM; Lourenço A; Cruz MT; Martins JD; Ana Silva; Pereira, Sónia; Sousa MC. "Giardia lamblia modulates LPS-induced pro-inflammatory response in macrophages through cleavage of NF-kB p65RelA by proteases". Paper presented in MicroBiotec19 - Congress of Microbiology and Biotechnology, 2019.
  27. Sousa, Fábio J.; Carrascal, Mylene; Moreira, Paula Isabel; Santos, Armanda E; Cruz, Maria Teresa; Pereira, Cláudia. "Impact of ER stress on neuronal mitochondria". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  28. Brites , Gonçalo; Filipa, Silva; Ferreira, Isabel; Silva, Ana; Mylène A. Carrascal; Miguel Neves, Bruno; Cruz, Maria Teresa. "Managing allergic contact dermatitis: screening of molecules with potential for preventing the disease". Paper presented in 24th World Congress of Dermatology, 2019.
  29. Palmeira-de-Oliveira, Rita; Oliveira, A.S.; Vaz CV; Correia S.; Ferreira R.; Breitenfeld, L.; JMO - 8812-C62C-364F; et al. "The anti-inflammatory and anti-aging properties of Portuguese thermal waters". Paper presented in IV Congresso Científico Anual UBIPharma - Inovar e Reinventar a Prática Farmacêutica, 2018.
  30. Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Madeira, N; Cruz, Maria Teresa; Pereira, Cláudia. "Resposta ao stresse celular em células do sistema imune inato na doença Bipolar". Paper presented in 2º Semina´rio da Sociedade Portuguesa para o Estudo da Saúde Mental - SPESM, 2018.
  31. Ferreira, Isabel; Silva, Ana Cristina Rosa da; Martins, João Demétrio; Neves, Bruno Miguel; Cruz, Maria Teresa. "Respiratory and skin allergies: a matter of differential ROS origin and kinetics?". Paper presented in 14th Congress European Society of Contact Dermatitis, 2018.
  32. Oliveira, AS; Vaz CV; Silva A; Correia S; Ferreira R; Breitenfeld L; Martinez-de-Oliveira J; et al. "Antimicrobial activity and regenerating and healing properties of Portuguese thermal waters". Paper presented in 30TH IFSCC CONGRESS. Munich, Germany, 2018.
  33. Palmeira-de-Oliveira, A; Silva AC; Vaz CV; Oliveira, AS; Correia S; Ferreira R; Breitenfeld L; et al. "Anti-inflammatory activity of portuguese thermal waters". Paper presented in 54th Congress of the European Societies of Toxicology (EUROTOX 2018). Brussels, Belgium, 2018.
  34. Vaz CV; Silva AC; Oliveira, AS; Correia S; Ferreira R; Breitenfeld L; Martinez-de-Oliveira J; et al. "In vitro effect of portuguese thermal waters on inflammation biomarkers". Paper presented in XIII Annual CICS-UBI Symposium. Covilhã. Portugal, 2018.
  35. Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Cruz, Maria Teresa; Pereira, Cláudia. "Role of Mitochondria-Associated Membranes in the endoplasmic reticulum stress response in the innate immune system". Paper presented in MitoPorto International Symposium, 2018.
  36. Oliveira, AS; Vaz CV; Silva AC; Correia S; Ferreira R; Breitenfeld L; Martinez-de-Oliveira J; et al. "Effect of Portuguese Thermal Waters on Cell Viability and against Skin Commensal and Pathogenic Microorganisms". Paper presented in V Congresso da Sociedade Portuguesa de Ciências Cosmetológicas (COSMETINNOV). Porto, Portugal, 2018.
  37. Martins, VMR; Simões, J; Ferreira, Isabel; Cruz, Maria Teresa; Domingues, MR; Coimbra, MA. "The polysaccharides from Pterospartum Tridentatum (L.) willk. inflorescences and their contribution to in vitro macrophage nitric oxide production". Paper presented in XIXth EuroFoodChem Conference, 2017.
  38. Ferreira, Isabel; Silva, Ana Cristina Rosa da; Martins, João Demétrio; Neves, Bruno Miguel; Cruz, Maria Teresa. "Differential modulation of toxicity pathways by respiratory and cutaneous allergens: interaction with physiopathology". Paper presented in International Conference on Occupational & Environmental Toxicology, ICOETOX, 2016.
  39. Célia Cabral; Miranda, Margarida; M. J. Gonçalves; Cavaleiro, Carlos; Cruz, Maria Teresa; Ligia Salgueiro. "Essential oil of the Portuguese endemic Santolina impressa Hoffmanns. & Link: assessment of antifungal safe doses". Paper presented in 6th International Congress of Aromatic and Medicinal Plants (CIPAM2016), 2016.
  40. Martins, Vitor MR; Simões, Joana; Ferreira, Isabel; Cruz, Maria Teresa; Domingues, Maria Rosário; Coimbra, Manuel A. "Structural characterization and macrophage immunostimulatory activity of polysaccharides present in the hot water extracts from P. tridentatum dried inflorescences.". Paper presented in 3rd International Congress on Cocoa, Coffee and Tea, 2015.
  41. Martins, Vitor MR; Simões, Joana; Ferreira, Isabel; Cruz, Maria Teresa; Domingues, Maria Rosário; Coimbra, Manuel A. "Structural features and macrophage immunostimulatory activity of the polysaccharides from Fraxinus angustifolia and Mentha suaveolens hot water extracts". Paper presented in 3rd International Congress on Cocoa, Coffee and Tea, 2015.
  42. Abu-Darwish, MS; Cabral, Célia; Ferreira, Isabel; Gonçalves, MJ; Cavaleiro, Carlos; Cruz, Maria Teresa; Al-bdour, TH; Salgueiro, Lígia. "Essential oils of Salvia officinalis L. from Jordan: Assessment of safety in mammalian cells, and their antifungal and anti-inflammatory potential". Paper presented in 5th International Congress on Medicinal and Aromatic Plants ¿ CIPAM 2014, 2014.
  43. Liberal, Joana; Costa, Gustavo; Carmo, Anália; Cruz, Maria Teresa; Batista, Maria Teresa; Liberal, J.T.; Costa, G; et al. "Ellagitannin-enriched fraction from Fragaria vesca leaves inhibits proliferation and induces cell cycle arrest in the human hepatocellular carcinoma cell line HepG2". Paper presented in 8th World Congress on Polyphenols Applications - ISANH, 2014.
    10.1055/s-0033-1352234
  44. Martins, Vitor MR; Ferreira, Isabel; Cruz, Maria Teresa; Batista, Maria Teresa; Coimbra, Manuel A. "Pectic polysaccharides from the infusions of P. tridentatum, F. angustifolia and M. suaveolens: structural characterization and modulation of the inflammatory activity". Paper presented in 2nd International Congress on Cocoa, Coffee and Tea, 2013.
  45. Costa, Gustavo; Francisco, Vera; Liberal, Joana; Cruz, Maria Teresa; Lopes, Maria Celeste; Batista, Maria Teresa. "Inhibition of proteasome system by natural compounds: source of new anti-inflammatory and anti-cancer drugs". Paper presented in 6th European Congress of Pharmacology, 2012.
  46. Resende, Mariana; Moreira, Diana; Cunha, Joana; Augusto, J; Neves, Bruno; Cruz, Maria Teresa; Estaquier, Jerôme; Cordeiro-da-Silva, Anabela; Silvestre, Ricardo. "Leishmania-infected mature dendritic cells polarize CD4+ T cells towards a non-protective T-bet+ INF-gamma+ IL10+ phenotype". Paper presented in 3rd I3S Scientific Retreat, 2012.
  47. Gonçalo, Margarida; Coutinho, I.; Martins, J.; Neves, B.; Silva, Ana; Nunes, R.; Martinho, A.; Cruz, Maria Teresa; Lopes, Maria Celeste. "Severe adverse drug reactions from allopurinol. In vivo and in vitro studies to understand pathophysiology". 2012.
  48. Resende, Mariana; Moreira, Diana; Cunha, Joana; Neves, Bruno; Costa-Lima, Sofia; Cruz, Maria Teresa; Cordeiro-da-Silva, Anabela; Silvestre, Ricardo. "Infected but not Bystander Dendritic Cells polarize CD4+ T cells towards a non-protective T-bet+ INF-gamma+ IL10+ phenotype". Paper presented in XXXVII Annual Meeting of the Portuguese Society for Immunology, 2011.
  49. Rosa, Susana Carvalho; Neves, B.; Gonçalo, Margarida; Domingos, M. R.; Santinha, D.; Macedo, B.; Lopes, Maria Celeste; Cruz, Maria Teresa. "Modulation of sphingosine-1 receptors by LPs and the contact allergen PPD". 2011.
  50. Neves, B.; Rosa, Susana Carvalho; Gonçalo, Margarida; Martins, J.; Lopes, Maria Celeste; Cruz, Maria Teresa. "A in vitro cell test for skin sensitizers based on the analysis of gene expression and cell signaling pathways". 2011.
  51. Resende, Mariana; Silvestre, Ricardo; Neves, Bruno; Cunha, Joana; Cruz, Maria Teresa; Cordeiro-da-Silva, Anabela. "Differential effect of Leishmania infantum on infected and bystander dendritic cells". Paper presented in XXXVI Annual Meeting of the Portuguese Society for Immunology, 2010.
  52. Neves, Bruno; Silvestre, Ricardo; Cunha, Joana; Tavares, Joana; Resende, Mariana; Ouaissi, Ali; Lopes, MC; Cruz, Maria Teresa; Cordeiro-da-Silva, Anabela. "Poster PA11/60 Immunomodulation of dendritic cells by virulent and attenuated Leishmania infantum strains". Paper presented in European Congress of Immunology 2009, 2009.
  53. Ralha, T.; Jacinto, N.; Gonçalo, Margarida; Cruz, Maria Teresa; Figueiredo, Américo; Lopes, Maria Celeste. "Expressão da iNOS induzida por alergenos em células dendríticas da pele". 2006.
  54. Jacinto, N.; Ralha, T.; Gonçalo, Margarida; Cruz, Maria Teresa; Figueiredo, Américo; Lopes, Maria Celeste. "Efeito de imunossupressores na expressão de iNOS induzida pelo níquel em células dendríticas da pele". 2006.
  55. Cruz, Maria Teresa; Gonçalo, Margarida; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria Celeste. "Effect of immunossupressive drugs on nitric oxide production induced by skin sensitizers". 2006.
  56. Cruz, Maria Teresa; Sagradas, J.; Gonçalo, Margarida; Duarte, Carlos B.; Lopes, Maria Celeste. "Transcription factor NF-¿B activation in skin dendritic cells". 2005.
  57. Gonçalo, Margarida; Vital, A. L.; Cruz, Maria Teresa; Lopes, Maria Celeste; Figueiredo, Américo. "Dexamethasone inhibits dendritic cell activation by skin sensitizers". 2004.
  58. Cruz, Maria Teresa; Vital, A. L.; Gonçalo, Margarida; Duarte, Carlos B.; Lopes, Maria Celeste. "The contact sensitizer nickel sulfate activates the transcription factors NF-kB and AP-1 and increases the expression of the inducible isoform of nitric oxide synthase in a skin dendritic cell line". 2003.
  59. Vital, A. L.; Cruz, Maria Teresa; Gonçalo, Margarida; Duarte, Carlos B.; Lopes, Maria Celeste. "Nitric oxide synthase type II expression and NF-kB activation by GM-CSF in a skin dendritic cell line". 2003.
  60. Vital, A. L.; Gonçalo, Margarida; Cruz, Maria Teresa; Duarte, Carlos B.; Lopes, Maria Celeste. "Expression of CD40 costimulatory molecule and IL-12 receptor induced by the sensitizers nickel and dinitrofluorobenzene in a fetal skin dendritic cell line". 2003.
  61. Cruz, Maria Teresa; Gonçalo, Margarida; Figueiredo, Américo; Carvalho A. P.; Duarte, Carlos B.; Lopes, Maria Celeste. "The contact sensitizer nickel activates the transcritpion factors NF-kB and AP-1 and induces the expression of nitric oxide synthase in a skin dendritic cell line". 2002.
  62. Lopes, Maria Celeste; Vital, A. L.; Cruz, Maria Teresa; Gonçalo, Margarida; Duarte, Carlos B.; Figueiredo, Américo; Carvalho A. P.. "GM-CSF activates PKC and PI3K and induces the expression of the nitric oxide synthase type II in a mouse dendrtitic cell line". 2002.
  63. Vital, A. L.; Gonçalo, Margarida; Cruz, Maria Teresa; Duarte, Carlos B.; Figueiredo, Américo; Carvalho A. P.; Lopes, Maria Celeste. "GM-CSF activates Pi3 kinase and induces the expression of the nitric oxide synthase type II in a mouse dendritic cell line". 2002.
  64. Vital, A. L.; Gonçalo, Margarida; Figueiredo, Américo; Carvalho A. P.; Duarte, Carlos B.; Lopes, Maria Celeste; Cruz, Maria Teresa. "Expression of CD40 costimulatory molecule and IL-12 receptor induced by the sensitizers nickel and dinitrofluorbenzene in a fetal skin dendritic cell line". 2002.
  65. Vital, A. L.; Cruz, Maria Teresa; Gonçalo, Margarida; Duarte, Carlos B.; Figueiredo, Américo; Carvalho A. P.; Lopes, Maria Celeste. "The sensitizer dinitrofluorbenzene induces the expression of CD40 and IL-12 receptor in a fetal skin dendritic cell line". 2001.
  66. Cruz, Maria Teresa; Carvalho, J. N. P.; Gonçalo, Margarida; Lopes, Maria Celeste. "The skin irritant tributyl causes cell death of a skin dendritic cell line". 2000.
  67. Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Carvalho A. P.; Lopes, Maria Celeste. "The colony stimulating factor GM-CSF activates transcritpion factors and induces the NO synthase type II expression in a mouse skin dendritic cell line". 2000.
  68. Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Carvalho A. P.; Lopes, Maria Celeste. "Intracellular signalling involved in nitric oxide production by a skin dendritic cell line activated by GM-CSF". 2000.
  69. Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Carvalho A. P.; Lopes, Maria Celeste. "Signal transduction for the expression of the inducible NO synthase induced by LPS in a fetal skin dendritic cell line". 1999.
Edited book
  1. Cruz, Maria Teresa; Silva Babo, Maria Augusta Pérez da ; Pinto, José G.. CRUZ, M.Teresa, BABO, M. Augusta, PINTO, José G. (org.) (2016) Tecnologias Culturais e Artes dos Media, Lisboa, Rio de janeiro: Leya / Unyleya (e-book) (ISBN BR: 978-85441-0493-4 / ISBN PT: 9789899850361). 2016.
    Published
Journal article
  1. Jorge M. Alves-Silva; Sónia Pedreiro; Mónica Zuzarte; Maria Teresa Cruz; Artur Figueirinha; Lígia Salgueiro. "Unlocking the Bioactive Potential and Exploring Novel Applications for Portuguese Endemic Santolina impressa". Plants (2024): https://doi.org/10.3390/plants13141943.
    10.3390/plants13141943
  2. Panão Costa, João; Jesus, Sandra; Colaço, Mariana; Lebre, Filipa; Mateus, Daniela; Sebastião, Ana Isabel; Cruz, Maria Teresa; Alfaro-Moreno, Ernesto; Borges, Olga. "Exploring the immunomodulatory properties of glucan particles in human primary cells". International Journal of Pharmaceutics 655 123996 (2024): https://www.sciencedirect.com/science/article/pii/S0378517324002308?via%3Dihub.
    Published
  3. Galrinho, Miguel; Silva, Lisete; Lopes, Guido R.; Bernardo A. C. Ferreira; Valente, Sara A.; Isabel Ferreira; Pinheiro, Benedita; et al. Corresponding author: Passos, Claudia P.. "The study of galactomannans with different molecular weights and their ability to form microparticles suitable for pulmonary delivery". Carbohydrate Polymers (2024):
    Under revision
  4. Sandra Mota; Gonçalo P. Rosa; Maria Carmo Barreto; Jorge Garrido; Emília Sousa; Maria T. Cruz; Isabel F. Almeida; Clara Quintas. "Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmenting Agents". Pharmaceuticals (2023): https://doi.org/10.3390/ph17010055.
    10.3390/ph17010055
  5. Daniela Mateus; Ana I. Sebastião; Manuela F. Frasco; Mylène A. Carrascal; Amílcar Falcão; Célia M. Gomes; Bruno Neves; Maria G. F. Sales; Maria T. Cruz. "Artificial Dendritic Cells: A New Era of Promising Antitumor Immunotherapy". Small (2023): https://doi.org/10.1002/smll.202303940.
    10.1002/smll.202303940
  6. Clarissa Perez Faria; Maria de Fátima Matos Almeida Henriques de Macedo; Barbara Ferreira; Ágata Lourenço; Inês Guerra; Tânia Melo; Pedro Domingues; et al. "Lipidome of extracellular vesicles from Giardia lamblia". PLOS ONE (2023): https://doi.org/10.1371/journal.pone.0291292.
    10.1371/journal.pone.0291292
  7. Isabel Ferreira; Gonçalo Brites; Ana Silva; Francisco Caramelo; Bárbara Oliveiros; Bruno Miguel Neves; Maria Teresa Cruz. "Development of an in chemico high-throughput screening method for the identification of skin sensitization potential". Archives of Toxicology (2023): https://doi.org/10.1007/s00204-023-03550-z.
    10.1007/s00204-023-03550-z
  8. Jorge Miguel Alves-Silva; Sónia Pedreiro; Cruz MT; Salgueiro L.; Artur Figueirinha. "Exploring the Traditional Uses of Thymbra capitata Infusion in Algarve (Portugal): Anti-Inflammatory, Wound Healing, and Anti-Aging". Pharmaceuticals (2023): https://www.mdpi.com/1424-8247/16/9/1202.
    10.3390/ph16091202
  9. Jorge M. Alves-Silva; Sónia Pedreiro; Carlos Cavaleiro; Maria Teresa Cruz; Artur Figueirinha; Lígia Salgueiro. "Effect of Thymbra capitata (L.) Cav. on Inflammation, Senescence and Cell Migration". Nutrients (2023): https://doi.org/10.3390/nu15081930.
    10.3390/nu15081930
  10. Ana Torres; Liliana Rego; Márcia S. Martins; Marta S. Ferreira; Maria T. Cruz; Emília Sousa; Isabel F. Almeida. "How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies". Pharmaceuticals (2023): https://doi.org/10.3390/ph16040573.
    10.3390/ph16040573
  11. Sara A. Valente; Guido R. Lopes; Isabel Ferreira; Miguel F. Galrinho; Margarida Almeida; Paula Ferreira; Maria T. Cruz; Manuel A. Coimbra; Cláudia P. Passos. "Polysaccharide-Based Carriers for Pulmonary Insulin Delivery: The Potential of Coffee as an Unconventional Source". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041213.
    10.3390/pharmaceutics15041213
  12. Ana Jesus; Ana I. Sebastião; Gonçalo Brites; Marta Correia-da-Silva; Honorina Cidade; Maria T. Cruz; Emília Sousa; Isabel F. Almeida. "A Hydrophilic Sulfated Resveratrol Derivative for Topical Application: Sensitization and Anti-Allergic Potential". Molecules (2023): https://doi.org/10.3390/molecules28073158.
    10.3390/molecules28073158
  13. Cátia. S. D. Oliveira; Patrícia Moreira; Maria T. Cruz; Cláudia M. F. Pereira; Artur M. S. Silva; Sónia A. O. Santos; Armando J. D. Silvestre. "Exploiting the Integrated Valorization of Eucalyptus globulus Leaves: Chemical Composition and Biological Potential of the Lipophilic Fraction before and after Hydrodistillation". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24076226.
    10.3390/ijms24076226
  14. Jorge Miguel Alves-Silva; Delia Maccioni; Emma Cocco; Maria José Gonçalves; Silvia Porcedda; Alessandra Piras; Maria Teresa Cruz; Lígia Salgueiro; Andrea Maxia. "Advances in the Phytochemical Characterisation and Bioactivities of Salvia aurea L. Essential Oil". Plants (2023): https://doi.org/10.3390/plants12061247.
    10.3390/plants12061247
  15. Ana Isabel Sebastião; Daniela Mateus; Mylène A. Carrascal; Cátia Sousa; Luísa Cortes; Martin F. Bachmann; Anália do Carmo; et al. "CuMV VLPs Containing the RBM from SARS-CoV-2 Spike Protein Drive Dendritic Cell Activation and Th1 Polarization". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15030825.
    10.3390/pharmaceutics15030825
  16. Mariana Colaço; Tiago Roquito; João Panão Costa; Maria Teresa Cruz; Olga Borges. "The Effect of Curcumin-Loaded Glucan Nanoparticles on Immune Cells: Size as a Critical Quality Attribute". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15020623.
    10.3390/pharmaceutics15020623
  17. Jorge M. Alves-Silva; Maria José Gonçalves; Ana Silva; Carlos Cavaleiro; Maria Teresa Cruz; Lígia Salgueiro. "Chemical Profile, Anti-Microbial and Anti-Inflammaging Activities of Santolina rosmarinifolia L. Essential Oil from Portugal". Antibiotics (2023): https://doi.org/10.3390/antibiotics12010179.
    10.3390/antibiotics12010179
  18. Jorge M. Alves-Silva; Emma Cocco; Alessandra Piras; Maria José Gonçalves; Ana Silva; Danilo Falconieri; Silvia Porcedda; et al. "Unveiling the Chemical Composition and Biological Properties of Salvia cacaliifolia Benth. Essential Oil". Plants (2023): https://doi.org/10.3390/plants12020359.
    10.3390/plants12020359
  19. Ana Jesus; Sandra Mota; Ana Torres; Maria T. Cruz; Emília Sousa; Isabel F. Almeida; Honorina Cidade. "Antioxidants in Sunscreens: Which and What For?". Antioxidants (2023): https://doi.org/10.3390/antiox12010138.
    10.3390/antiox12010138
  20. B.J. Conti; K.B. Santiago; E.O. Cardoso; F.L. Conte; M.A. Golim; M.T. Cruz; J.M. Sforcin. "Effect of propolis on Th2 and Th17 cells: interplay with EtxB- and LPS-treated dendritic cells". Brazilian Journal of Medical and Biological Research (2023): https://doi.org/10.1590/1414-431x2023e12659.
    10.1590/1414-431x2023e12659
  21. Cátia S. D. Oliveira; Patrícia Moreira; Maria T. Cruz; Cláudia M. F. Pereira; Alexandre Gaspar; Carlos Pascoal Neto; Paula C. R. O. Pinto; et al. "An integrated green process for the extraction of triterpenic acids from Eucalyptus globulus leaves after hydrodistillation". RSC Sustainability (2023): https://doi.org/10.1039/D3SU00076A.
    10.1039/D3SU00076A
  22. Ana Jesus; Inês Augusto; Joana Duarte; Emília Sousa; Honorina Cidade; Maria T. Cruz; José M. Sousa Lobo; Isabel F. Almeida. "Recent Trends on UV filters". Applied Sciences (2022): https://doi.org/10.3390/app122312003.
    10.3390/app122312003
  23. Cruz MT. "Development of colorimetric cellulose-based test-strip for the rapid detection of antibodies against SARS-CoV2 virus.". Cellulose (London, England) (2022): https://europepmc.org/articles/PMC9483301.
    10.1007/s10570-022-04808-y
  24. Patrícia Moreira; Patrícia Matos; Artur Figueirinha; Lígia Salgueiro; Maria Teresa Batista; Pedro Costa Branco; Maria Teresa Cruz; Cláudia Fragão Pereira. "Forest Biomass as a Promising Source of Bioactive Essential Oil and Phenolic Compounds for Alzheimer’s Disease Therapy". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23158812.
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  25. Marcelo D. Catarino; Ana Rita Circuncisão; Bruno Neves; Catarina Marçal; Artur M. S. Silva; Maria Teresa Cruz; Susana M. Cardoso. "Impact of Gastrointestinal Digestion on the Anti-Inflammatory Properties of Phlorotannins from Himanthalia elongata". Antioxidants (2022): https://doi.org/10.3390/antiox11081518.
    10.3390/antiox11081518
  26. Vaz CV; Oliveira AS; Silva A; Cortes L; Correia S; Ferreira R; Breitenfeld L; et al. "Protective role of Portuguese natural mineral waters on skin aging: in vitro evaluation of anti-senescence and anti-oxidant properties.". International journal of biometeorology (2022): http://europepmc.org/abstract/med/35994120.
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  27. Cardoso, Ana Rita; João Frederico Alves; Frasco, Manuela F; Ana Margarida L. Piloto; Serrano, Verónica; Mateus, Daniela; Sebastião, Ana Isabel; et al. Corresponding author: Maria Goreti Ferreira Sales. "An ultra-sensitive electrochemical biosensor using the Spike protein for capturing antibodies against SARS-CoV-2 in point-of-care". Materials Today Bio 16 100354 (2022):
    Published
  28. Sara Oliveira; Tamaeh Monteiro-Alfredo; Rita Henriques; Carlos Fontes Ribeiro; Raquel Seiça; Teresa Cruz; Célia Cabral; et al. "Improvement of Glycaemia and Endothelial Function by a New Low-Dose Curcuminoid in an Animal Model of Type 2 Diabetes". International Journal of Molecular Sciences 23 10 (2022): 5652-5652. https://doi.org/10.3390/ijms23105652.
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  29. "Exploring the antioxidant, anti-inflammatory and antiallergic potential of Brazilian propolis in monocytes". Phytomedicine Plus 2 2 (2022): 100231-100231. http://dx.doi.org/10.1016/j.phyplu.2022.100231.
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  30. "Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer’s disease: Past, present and future". Ageing Research Reviews 77 (2022): 101612-101612. http://dx.doi.org/10.1016/j.arr.2022.101612.
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  31. "ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system". Cellular and Molecular Life Sciences 79 4 (2022): http://dx.doi.org/10.1007/s00018-022-04211-7.
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  32. Diana I. S. P. Resende; Ana Jesus; José M. Sousa Lobo; Emília Sousa; Maria T. Cruz; Honorina Cidade; Isabel F. Almeida. "Up-to-Date Overview of the Use of Natural Ingredients in Sunscreens". Pharmaceuticals 15 3 (2022): 372-372. https://doi.org/10.3390/ph15030372.
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  33. Patrícia Moreira; Fábio J. Sousa; Patrícia Matos; Brites, G; Maria José Gonçalves; Carlos Cavaleiro; Artur Figueirinha; et al. "Chemical Composition and Effect against Skin Alterations of Bioactive Extracts Obtained by the Hydrodistillation of Eucalyptus globulus Leaves". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/3/561.
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  34. Ana Jesus; Emília Sousa; Maria T. Cruz; Honorina Cidade; José M. Sousa Lobo; Isabel F. Almeida. "UV Filters: Challenges and Prospects". Pharmaceuticals 15 3 (2022): 263-263. https://doi.org/10.3390/ph15030263.
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  35. Monica Zuzarte; Cátia Sousa; Carlos Cavaleiro; Maria Teresa Cruz; Lígia Salgueiro. "The Anti-Inflammatory Response of Lavandula luisieri and Lavandula pedunculata Essential Oils". Plants (2022): https://doi.org/10.3390/plants11030370.
    10.3390/plants11030370
  36. Ana Catarina Pereira; Nuno Madeira; Sofia Morais; António Macedo; Maria Teresa Cruz; Cláudia M. F. Pereira. "Mitochondria Fusion upon SERCA Inhibition Prevents Activation of the NLRP3 Inflammasome in Human Monocytes". Cells 11 3 (2022): 433-433. https://doi.org/10.3390/cells11030433.
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  37. Zuzarte, Monica; Francisco, Vera; Neves, Bruno; Liberal, Joana; Cavaleiro, Carlos; Canhoto, Jorge; Salgueiro, Lígia; Cruz, Maria Teresa; Salgueiro, Ligia. "Lavandula viridis L´Hér. Essential Oil Inhibits the Inflammatory Response in Macrophages Through Blockade of NF-KB Signaling Cascade". Frontiers in Pharmacology 12 (2022): http://dx.doi.org/10.3389/fphar.2021.695911.
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  38. Marcelo D. Catarino; Iva Fernandes; Hélder Oliveira; Mylene Carrascal; Rita Ferreira; Artur M. S. Silva; Maria Teresa Cruz; Nuno Mateus; Susana M. Cardoso. "Antitumor Activity of Fucus vesiculosus-Derived Phlorotannins through Activation of Apoptotic Signals in Gastric and Colorectal Tumor Cell Lines". International Journal of Molecular Sciences 22 14 (2021): 7604-7604. https://doi.org/10.3390/ijms22147604.
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  39. Mónica Zuzarte; Pedro M. P. Correia; Jorge M. Alves-Silva; Maria J. Gonçalves; Carlos Cavaleiro; Teresa Cruz; Lígia Salgueiro. "Antifungal and Anti-Inflammatory Potential of Bupleurum rigidum subsp. paniculatum (Brot.) H.Wolff Essential Oil". Antibiotics 10 5 (2021): 592-592. https://doi.org/10.3390/antibiotics10050592.
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  40. Diva Silva; Marta Salvador Ferreira; José Manuel Sousa-Lobo; Maria Teresa Cruz; Isabel Filipa Almeida. "Anti-Inflammatory Activity of Calendula officinalis L. Flower Extract". Cosmetics (2021): https://doi.org/10.3390/cosmetics8020031.
    10.3390/cosmetics8020031
  41. Cláudia P. Passos; Rita M. Costa; Sónia S. Ferreira; Guido R. Lopes; Maria T. Cruz; Manuel A. Coimbra. "Role of Coffee Caffeine and Chlorogenic Acids Adsorption to Polysaccharides with Impact on Brew Immunomodulation Effects". Foods (2021): https://doi.org/10.3390/foods10020378.
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  42. Calmeiro, J.; Carrascal, M.A.; Tavares, A.R.; Ferreira, D.A.; Gomes, C.; Cruz, M.T.; Falcão, A.; et al. "Pharmacological combination of nivolumab with dendritic cell vaccines in cancer immunotherapy: An overview". Pharmacological Research 164 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85099552475&partnerID=MN8TOARS.
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  187. Tavares, A.C.; Gonçalves, M.J.; Cavaleiro, C.; Cruz, M.T.; Lopes, M.C.; Canhoto, J.; Salgueiro, L.R.; et al. "Essential oil of Daucus carota subsp. halophilus: Composition, antifungal activity and cytotoxicity". Journal of Ethnopharmacology 119 1 (2008): 129-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349115295&partnerID=MN8TOARS.
    10.1016/j.jep.2008.06.012
  188. Neves, B.M.; Cruz, M.T.; Francisco, V.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.; et al. "Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSDC cell line". Toxicology Letters 177 1 (2008): 74-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-39549123001&partnerID=MN8TOARS.
    10.1016/j.toxlet.2007.12.006
  189. Carmo, A.; Patrlcio, M. I.; Amaro, P.; Cruz, M. T.; Lopes, M. C.. "CXCR4 expression mediates the survival and proliferation of glioma cells". Ejc Supplements 6 9 (2008): 20-20. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000257919000078&KeyUID=WOS:000257919000078.
    10.1016/s1359-6349(08)71252-7
  190. Neves, B.; Cruz, M. T.; Goncalo, M.; Figueiredo, A.; Duarte, C. B.; Lopes, M. C.. "Differential CXCR4 expression induced by skin sensitizers or irritants in dendritic cell models". Journal of Investigative Dermatology 127 (2007): S5-S5. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000249933400026&KeyUID=WOS:000249933400026.
  191. Cruz, M.T.; Neves, B.M.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.. "Effect of skin sensitizers on inducible nitric oxide synthase expression and nitric oxide production in skin dendritic cells: Role of different immunosuppressive drugs". Immunopharmacology and Immunotoxicology 29 2 (2007): 225-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548553284&partnerID=MN8TOARS.
    10.1080/08923970701512304
  192. Vital, A.L.; Gonçalo, M.; Cruz, M.T.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.. "The sensitizers nickel sulfate and 2,4-dinitrofluorobenzene increase CD40 and IL-12 receptor expression in a fetal skin dendritic cell line". Bioscience Reports 24 3 (2005): 191-202. http://www.scopus.com/inward/record.url?eid=2-s2.0-23944504971&partnerID=MN8TOARS.
    10.1007/s10540-005-2580-7
  193. Cruz, M.T.; Gonçalo, M.; Paiva, A.; Morgado, J.M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.. "Contact sensitizers downregulate the expression of the chemokine receptors CCR6 and CXCR4 in a skin dendritic cell line". Archives of Dermatological Research 297 1 (2005): 43-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-25644435637&partnerID=MN8TOARS.
    10.1007/s00403-005-0574-8
  194. Cruz, M.T.; Gonçalo, M.; Figueiredo, A.; Carvalho, A.P.; Duarte, C.B.; Lopes, M.C.. "Contact sensitizer nickel sulfate activates the transcription factors NF-kB and AP-1 and increases the expression of nitric oxide synthase in a skin dendritic cell line". Experimental Dermatology 13 1 (2004): 18-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-0842308107&partnerID=MN8TOARS.
    10.1111/j.0906-6705.2004.00105.x
  195. Vital, Ana Luísa; Gonçalo, Margarida; Cruz, Maria Teresa; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria Celeste. "The Sensitizers Nickel Sulfate and 2,4-dinitrofluorobenzene Increase CD40 and IL-12 Receptor Expression in a Fetal Skin Dendritic Cell Line". (2004): http://hdl.handle.net/10316/7941.
  196. Cruz, Maria Teresa; Gonçalo, Margarida; Américo Figueiredo; Carvalho A. P.; Duarte, Carlos B.; Lopes, Maria Celeste. "The contact sensitizer Nickel sulphate activates the transcription factor NF-kB and AP-1 and induces the expression of nitric oxide in a skin dendritic cell line". Experimental Dermatol 13 (2004): 18-26.
    Published
  197. Vital, A. L.; Gonçalo, Margarida; Cruz, Maria Teresa; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria Celeste. "The sensitizers nickel sulfate and 2,4-dinitrofluorobenzene induce the expression of CD40 and IL-12 receptor in a fetal skin dendritic cell line, whereas 2,4-dichloronitrobenzene has no effect.". Bioscience Reports 24 (2004): 191-202.
    Published
  198. Cruz, M. T.; Duarte, C. B.; Goncalo, M.; Figueiredo, A.; Carvalho, A. P.; Lopes, M. C.; Cruz, M.T.; et al. "The sensitizer 2,4-dinitrofluorobenzene activates caspase-3 and induces cell death in a skin dendritic cell line". International Journal of Toxicology 22 1 (2003): 43-48. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000180837500006&KeyUID=WOS:000180837500006.
    10.1080/10915810390181490
  199. Vital, A.L.; Gonçalo, M.; Cruz, M.T.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.. "Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-¿B activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line". Mediators of Inflammation 12 2 (2003): 71-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038466135&partnerID=MN8TOARS.
    10.1080/0962935031000097673
  200. Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Figueiredo, Américo; Carvalho, Arsélio P.; Lopes, Maria Celeste. "The Sensitizer 2,4-Dinitrofluorobenzene Activates Caspase-3 and Induces Cell Death in a Skin Dendritic Cell Line". (2003): http://hdl.handle.net/10316/11811.
  201. Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Figueiredo, Américo; Carvalho A. P.; Lopes, Maria Celeste. "The sensitizer 2,4 dinitrofluorbenzene induces cell death in a skin dendritic cell line by activating caspase 3". International Journal of Toxicology 22 (2003): 43-48.
    Published
  202. Vital, A. L.; Gonçalo, Margarida; Cruz, Maria Teresa; Duarte, Carlos B.; Figueiredo, Américo; Carvalho A. P.; Lopes, Maria Celeste. "Dexamethasone prevents GM-CSF induced NF-kB activation, iNOS expression and NO production in a skin dendritic cell line". Mediators Inflammation 12 (2003): 71-78.
    Published
  203. Cruz MT; Duarte CB; Gonçalo M; Figueiredo A; Carvalho AP; Lopes MC; Cruz, M. T.; et al. "Differential activation of nuclear factor kappa B subunits in a skin dendritic cell line in response to the strong sensitizer 2,4-dinitrofluorobenzene.". Archives of Dermatological Research 294 9 (2002): 419-425. http://europepmc.org/abstract/med/12522580.
    10.1007/s00403-002-0342-y
  204. Cruz, M.T.; Duarte, C.B.; Gonçalo, M.; Figueiredo, A.; Carvalho, A.P.; Lopes, M.C.. "Granulocyte-macrophage colony-stimulating factor activates the transcription of nuclear factor kappa B and induces the expression of nitric oxide synthase in a skin dendritic cell line". Immunology and Cell Biology 79 6 (2001): 590-596. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035176476&partnerID=MN8TOARS.
    10.1046/j.1440-1711.2001.01041.x
  205. Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Carvalho A. P.; Lopes, Maria Celeste; Cruz, M.T.; Duarte, C.B.; et al. "LPS induction of IkB-¿ degradation and iNOS expression in a skin dendritic cell line is prevented by the Janus Kinase 2 inhibitor, tyrphostin B42". Nitric Oxide: Biology and Chemistry 5 5 (2001): 53-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035708551&partnerID=MN8TOARS.
    Published • 10.1006/niox.2000.0320
  206. Gomes, E. R.; Cruz, T.; Lopes, C. F.; Carvalho, A. P.; Duarte, C. B.; Gomes, E.R.; Lopes, C.F.; Carvalho, A.P.; Duarte, C.B.. "Photosensitization of lymphoblastoid cells with phthalocyanines at different saturating incubation times". Cell Biology and Toxicology 15 4 (1999): 249-260. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000084642800005&KeyUID=WOS:000084642800005.
    10.1023/a:1007615813184
  207. Cruz, M.T.; Duarte, C.B.; Gonçalo, M.; Carvalho, A.P.; Lopes, M.G.; Cruz, M. T.; Duarte, C. B.; et al. "Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells". American Journal of Physiology - Cell Physiology 277 6 46-6 (1999): C1050-C1057. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033373205&partnerID=MN8TOARS.
    10.1152/AJPCELL.1999.277.6.C1050
  208. Cruz, M.T.; Carmo, A.; Carvalho, A.P.; Lopes, M.C.. "Calcium-dependent nitric oxide synthase activity in rat thymocytes". Biochemical and Biophysical Research Communications 248 1 (1998): 98-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032499870&partnerID=MN8TOARS.
    10.1006/bbrc.1998.8865
  209. Mendes, AF; Wong, H; Caramona, MM; Carvalho, AP; Lopes, MC; Cruz, TF. "Inhibition of ROS production prevents IL-1ß-induced iNOS expression in articular chondrocytes". Naunyn-Schmiedeberg's Archives of Pharmacology (1998): https://publons.com/wos-op/publon/10621892/.
  210. Cruz, T.; Gaspar, R.; Donato, A.; Lopes, C.. "Interaction between polyalkylcyanoacrylate nanoparticles and peritoneal macrophages: MTT metabolism, NBT reduction, and NO production". Pharmaceutical Research 14 1 (1997): 73-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031042535&partnerID=MN8TOARS.
    10.1023/A:1012059501947
Newspaper article
  1. Resende, Rosa; Silva, Ana; Cláudia Maria Fragão Pereira (PhD); Moreira, Paula Isabel; Santos, Armanda E; Cruz, Maria Teresa; Fernandes, Tânia; et al. "Doenças neurodegenerativas: um quebra-cabeças com solução à vista", O Público, 2021
  2. Cruz, Maria Teresa. "Portuguese Natural Mineral Waters: chemical signature and antimicrobial activity against skin pathogenic and commensal microorganisms", 2020
Preprint
  1. Clarissa Pérez Faria; Sandra Jesus; Ágata Lourenço; Bárbara Ferreira; Ana Isabel; Daniela Mateus; Bruno Neves; et al. "Unraveling the potential of Giardia extracellular vesicles as a vaccine candidat". 2024. https://doi.org/10.20944/preprints202403.0845.v1.
    10.20944/preprints202403.0845.v1
  2. Jorge M. Alves-Silva; Patrícia Moreira; Carlos Cavaleiro; Cláudia Pereira; Maria Teresa Cruz; Lígia Salgueiro. "Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging". 2023. https://doi.org/10.20944/preprints202310.1432.v1.
    10.20944/preprints202310.1432.v1
  3. Silva, Ana; Silva, Sónia; Macedo, Jéssica; Moreira, Patrícia; Baptista, Diana; Bicker, Joana; Fortuna, Ana; et al. "Targeting Alzheimer's disease hallmarks with the Nrf2 activator Isoeugenol". 2023. http://dx.doi.org/10.32388/luxm7w.
    10.32388/luxm7w
Thesis / Dissertation
  1. Oliveira, Constança Pinto Cruz Bonito de. "Internship and Monograph reports entitled”Exosomes as new therapeutic vectors for pancreatic cancer treatment"". Master, 2020. http://hdl.handle.net/10316/93113.
  2. Sebastião, Ana Isabel Madaleno. "Internship and Monograph reports entitled “NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify”.". Master, 2020. http://hdl.handle.net/10316/93094.
  3. Marques, Sara Gabriela Costa. "Relatórios de Estágio e Monografia intitulada “Fumarato de Dimetilo, da Esclerose Múltipla às doenças Neurodegenerativas”". Master, 2020. http://hdl.handle.net/10316/93027.
  4. Portugal, Ricardo Antunes. "Dados do mundo real relativos ao tratamento com pembrolizumab de doentes com cancro do pulmão de células não-pequenas em estadio avançado previamente tratados.". Master, 2020. http://hdl.handle.net/10316/92926.
  5. Pereira, Marta Sofia Rosendo. "Skin allergens: Molecules with an improbable therapeutic application for Alzheimer's disease". Master, 2019. http://hdl.handle.net/10316/89648.
  6. Silva, Filipa Alexandra Lopes Simões da. "Sensibilizadores cutâneos: novas abordagens para previsão de toxicidade e gestão do risco". Master, 2019. http://hdl.handle.net/10316/88098.
  7. Mateus, Daniela Marques. "Relatório de Estágio e Monografia intitulada "Células T CAR - Uma nova estratégia imunoterapêutica".". Master, 2019. http://hdl.handle.net/10316/88339.
  8. Oliveira, Joana Margarida Monteiro. "Relatórios de Estágio e Monografia intitulada “Envolvimento da inflamação na doença bipolar: identificação de novos alvos terapêuticos”". Master, 2019. http://hdl.handle.net/10316/88293.
  9. Silva, Inês Filipa Cruz Soares. "To explore the use of a BH3-mimetic (ABT-737) as a chemosensitizer of osteosarcoma cells to doxorubicin.". Master, 2019. http://hdl.handle.net/10316/88347.
  10. Ribeiro, Inez Quaresma. "Estratégias Imunoterapêuticas aplicadas à Doença de Parkinson". Master, 2018. http://hdl.handle.net/10316/84495.
  11. Alves, Joana Filipa Catarino. "Chemo-enzymatic synthesis of new flavonoid derivatives with anti-inflammatory activity". Master, 2018. http://hdl.handle.net/10316/84606.
  12. Nogueira, João Filipe Duarte. "Relatórios de Estágio e Monografia intitulada “Inflamassomas – da Investigação à Terapêutica”". Master, 2017. http://hdl.handle.net/10316/83634.
  13. Turé, Jorge. "Relatório de estágio em Farmácia Comunitária e Monografia intitulada: "PLANTAS MEDICINAIS UTILIZADAS NA GUINÉ BISSAU PARA O TRATAMENTO DA MALÁRIA"". Master, 2017. http://hdl.handle.net/10316/83637.
  14. Branco, Tiago Miguel Dinis Prata. "Relatórios de Estágio e Monografia intitulada “Autofagia e Inflamassoma - Crosstalk e Relevância Fisiopatológica no Cancro”". Master, 2017. http://hdl.handle.net/10316/83709.
  15. Barbosa, Josiane Magalhães. "Preparação e avaliação da atividade anti-inflamatória de novos derivados polifenólicos glicosilados". Master, 2016. http://hdl.handle.net/10316/36550.
  16. Liberal, Joana Manuela Torres. "Fragaria vesca leaf as a source of bioactive phytochemicals - a focus on ellagitannins and their human microflora metabolites". PhD, 2016. http://hdl.handle.net/10316/30182.
  17. Carvalho, Amadeu Manuel Rodrigues. "O papel do farmacêutico na dispensa de suplementos alimentares e dispositivos médicos na farmácia comunitária em Portugal e no Brasil". Master, 2016. http://hdl.handle.net/10316/42832.
  18. Évora, Leisa Nélida Pinto. "Actividades biológicas e citotoxidade do óleo essencial de Rosmarinus officinalis L.". Master, 2015. http://hdl.handle.net/10316/30998.
  19. Catarino, Marcelo Dias. "Phenolic characterization and evaluation of the antioxidant and anti-inflammatory properties of Eriocephalus africanus and Geranium robertianum extracts". Master, 2015. http://hdl.handle.net/10316/31068.
  20. Lourenço, Ana Rita Pinho. "Fisiopatologia e farmacoterapia da asma". Master, 2015. http://hdl.handle.net/10316/88861.
  21. Jorge, Maria Inês Lourenço. "Relatório de estágio em farmácia hospitalar". Master, 2015. http://hdl.handle.net/10316/88975.
  22. Rodrigues, Vanessa Raquel Fonseca. "Avaliação da atividade anti-inflamatória do óleo essencial de Thymus zygis subsp. sylvestris e dos seus compostos principais". Master, 2014. http://hdl.handle.net/10316/30177.
  23. Tellechea, Ana Luísa Alves. "Cellular and molecular mechanisms of impaired wound healing in diabetes : understanding the role of substance P and mast cells". PhD, 2014. http://hdl.handle.net/10316/26466.
  24. Correia, Marlise Barbosa. "Vacinas baseadas em células dendríticas na esclerose múltipla". Master, 2014. http://hdl.handle.net/10316/89341.
  25. Santinha, Deolinda da Conceição Ribafeita. "Changes in lipidomic profile induced by lipopolysaccharide and skin sensitizer in dendritic cells and keratinocytes". Master, 2011. http://hdl.handle.net/10316/31379.
  26. Silva, Lucília Pereira. "Neurotensin effect on skin dendritic cells and fibroblasts: repercussions in wound healing and diabetic wound healing". Master, 2010. http://hdl.handle.net/10316/28818.
  27. Marques, Diane Raphaela. "Avaliação de perfil lipídico de células dendríticas imaturas e maduras". Master, 2010. http://hdl.handle.net/10773/3147.
  28. Rosete, Maria Teresa de Teixeira Cruz. "Vias de sinalização intracelular envolvidas na expressão da isoforma indutível da sintase do No : efeito do lipopolissacarídeo, citocinas e alergénios em células dentríticas da pele". PhD, 2004. http://hdl.handle.net/10316/532.

Intellectual property

Patent
  1. 2022. "SMALL MOLECULES FOR USE IN PREVENTING AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES". Portugal.
    Pending
  2. Cruz, Maria Teresa; Neves, Bruno; Rosa, Susana; Amílcar Falcão; João D. Martins; Isabel Cristina Ferreira; Joana Filipa Sousa; Ana Cristina Rosa da Silva. 2016. "Method for Determining Low Molecular Weight Respiratory Allergens (Provisional Patent Application no201510000228)". Portugal.
    Granted/Issued
  3. Cruz, Maria Teresa. 2015. "Cork hydroglycolic extract, method for preparing same, formulations comprising said extract and use thereof".
    Pending
  4. Cruz, Maria Teresa. 2012. "Development of a dendritic cell-derived in vitro test to detect skin sensitizers".
    Expired
Provisional application for patent
  1. 2015. "AN IN SILICO AND IN VITRO INTEGRATIVE APPROACH TO ASSESS THE POTENCY OF CONTACT ALLERGENS".
  2. 2015. "METHOD FOR DETERMINING LOW MOLECULAR WEIGHT RESPIRATORY ALLERGENS".
    Protected
  3. 2014. "AN IN SILICO AND IN VITRO INTEGRATIVE APPROACH TO ASSESS THE POTENCY OF CONTACT ALLERGENS".
  4. 2014. "METHOD FOR DETERMINING LOW MOLECULAR WEIGHT RESPIRATORY ALLERGENS".
  5. 2014. "FUNCTIONALIZED MATRICES TO DETECT THE HAPTENIZATION CAPACITY OF XENOBIOTICS".
    Protected
  6. 2013. "A QUANTITATIVE APPROACH TO ASSESS THE POTENCY OF CONTACT ALLERGENS".
    Protected
  7. 2011. "AN IN VITRO CELL-BASED TEST FOR SKIN SENSITIZATION PREDICTION".

Other

Other output
  1. Imunoterapia baseada em células dendríticas no cancro pancreático. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. cancro pancreático (PC) representa um dos tumores sólidos mais agressivos e devastadores, caracterizado por apresentar uma elevada incidência e um mau prognóstico. As estratégias terapêuticas atuais são, muitas vezes, insat. 2016. Rosete, Maria Teresa Teixeira Cruz. http://hdl.handle.net/10316/43064.
  2. Alzheimer e vacinas terapêuticas. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. A doença de Alzheimer (AD) é uma doença progressiva, multifatorial e complexa, em que a fisiopatologia antecede cerca de 10 a 20 anos o aparecimento de sintomas clínicos. Ao longo dos anos, a patogénese da AD tem sido assoc. 2016. Rosete, Maria Teresa Teixeira Cruz. http://hdl.handle.net/10316/43062.
  3. Exosomes in Alzheimer's disease: potential biomarkers for pre-clinical diagnosis and their therapeutic role. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. Alzheimer disease (AD) is chronic, progressive, increasingly prevalent and has a long asymptomatic latency period. Current diagnosis of AD consists mainly in imaging techniques and measurement of bioindicators in the bodily. 2016. Rosete, Maria Teresa Teixeira Cruz. http://hdl.handle.net/10316/48528.
  4. Suplementos alimentares e dispositivos médicos na prevenção e tratamento de cististes recorrentes na mulher. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. Os suplementos alimentares e dispositivos médicos estão disponíveis nas farmácias comunitárias e constituem um instrumento relevante para um melhor aconselhamento farmacêutico. O aumento da comercialização e introdução dest. 2015. Rosete, Maria Teresa Teixeira Cruz. http://hdl.handle.net/10316/79834.
  5. O envolvimento das células dendríticas no lúpus eritematoso sistémico. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. O Lúpus Eritematoso Sistémico (LES) resulta de um funcionamento incorreto do sistema imunitário, afetando preferencialmente mulheres na sua idade fértil. O desenvolvimento desta patologia é modulado por fatores genéticos, h. 2015. Rosete, Maria Teresa. http://hdl.handle.net/10316/81309.
  6. Imunoterapia com células dendríticas: uma promessa para terapia de cancro. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. As células dendríticas (DCs) são consideradas o centro do sistema imunitário, dado que estabelecem a ligação entre a imunidade inata e adaptativa, apresentando capacidade de controlo não só da reposta imune, mas também da t. 2014. Rosete, Maria Teresa Teixeira Cruz. http://hdl.handle.net/10316/79621.
  7. Associação de vacinas baseadas em células dendríticas com quimioterapia : uma nova estratégia terapêutica contra o cancro. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. As células dendríticas são consideradas as células apresentadoras de antigénios mais potentes e desempenham um papel crucial na programação e regulação de respostas imunes específicas antitumorais. Devido às suas caracterís. 2014. Rosete, Maria Teresa Teixeira Cruz. http://hdl.handle.net/10316/80528.
Spin-off company
  1. 2012. Toxfinder Lda. Previsão Toxicológica. http://toxfinder.pt/pt-pt/.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020 - Current Circadian rhythm disruption in Bipolar disorder: from molecular mechanisms to novel therapeutic targets
Supervisor of Ana Catarina de Jesus Pais Pereira
2018 - Current Development of a Medical Device for prevention of Allergic Contact Dermatitis
Supervisor of Gonçalo Sousa Brites
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 - Current Characterization of phytochemical components of Eucalyptus globulus leaves and their pharmacological potentials: a multi-functional insight.
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017 - Current Desenvolvimento de plataformas baseadas em células dendriticas para screening toxicológico e farmacológico
Supervisor of João Miguel Calmeiro
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015 - Current Desenvolvimento de uma plataforma in-vitro/in chemico para a identificação de alergénios respiratórios
Supervisor of Isabel Ferreira
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - Current In vitro cellular approach for skin sensitization hazard: an EU legislation demand
Supervisor of Joao Demetrio Goncalves Boto Martins
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - Current Discovery of new anti-inflammatory drugs from natural products through bio-guided assays
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - Current Discovery of new anti-inflammatory and anti-fungal drugs from esential oils
Supervisor
2019/07 - 2020/07 Immunotherapy for pancreatic and lung cancer: Potentiation of antigen cross-presentation in dendritic-cell based vaccines.
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/07 - 2020/07 Avaliação do efeito dos regimes clássicos de quimioterapia e imunoterapia no perfil metabolómico de linhas celulares de cancro de pulmão de não pequenas células
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2020/07 Dados do mundo real do tratamento com pembrolizumab de doentes com cancro com pulmão de células não-pequenas em estadio avançado previamente tratados
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/07 - 2020/07 Pesquisa de novos Biomarcadores para o Carcinoma de células renais claras
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/07 - 2019/07 Skin allergens: molecules with an improbable therapeutic application for Alzheimer’s disease
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/07 - 2019 Skin sensitizers: moving forward new approaches for toxicity prevision and sensitization management”
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/07 - 2018/07 Chemo-enzymatic synthesis of new flavonoid derivatives with anti-inflammatory activity
Supervisor
2015 - 2016 O papel do farmacêutico na dispensa de suplementos alimentares e dispositivos médicos na farmácia comunitária em Portugal e no Brasil
Supervisor
2015/07 - 2015/07 Preparação e avaliação da actividade anti-inflamatória de novos derivados polifenólicos glicosilados
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/07 - 2015/07 THE ROLE OF CARDIOMYOCYTES-DERIVED EXOSOMES IN MACROPHAGE ACTIVATION AND POLARIZATION
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/07 - 2015/07 Bioactivity of essential oils obtained from Rosmarinus officinalis L.
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014 - 2015 Evaluation of the antioxidant and anti-inflammatory properties of Eriocephalus africanus extracts
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2014 Avaliação da atividade anti-inflamatória do óleo essencial de Thymus zygis subsp. sylvestris e dos seus compostos principais
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/09 - 2013/09 Evaluation of ER stress induced by DNFB in dendritic cells
Supervisor
Universidade de Aveiro, Portugal
2012 - 2013 AUTOPHAGY AND INFLAMMSOME: HOW ARE THEY RELATED?
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2009 - 2013 Anti-inflammatory mechanism and properties of plants used in traditional medicine: evaluation of their potential use as source for new anti-inflammatory drugs
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2009 - 2013 Molecular Mechanisms of Wound Healing
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/09 - 2011/09 Efeito de alergénios cutâneos no perfil lipídico de células dendríticas e queratinócitos
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - 2011 Alergias do Tracto Respiratório Rinite Alérgica/Asma
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - 2011 Reações de hipersensibilidade do aparelho respiratório
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - 2011 Diagnóstico e Tratamento das Doenças da Próstata
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2007 - 2011 Identification of cellular and molecular markers selectively activated by skin sensitizers in dendritic cells
Supervisor of Bruno Miguel Neves
Universidade de Coimbra Faculdade de Farmácia, Portugal
2009/07 - 2010/07 Neuropeptides and skin inflammation
Supervisor
2009/07 - 2010 Profiling changes triggered during dendritic cells maturation: a lipidomic approach
Supervisor
Universidade de Aveiro, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/02/05 - 2020/02/07 Membro da Comissão Organizadora e Científica da 50.ª Reunião da Sociedade Portuguesa de Farmacologia, 38.ª Reunião de Farmacologia Clínica e 19.ª Reunião de Toxicologia, que decorreu na FFUC (2020/02/05)
Congress
2019 - 2019 Co-organization of the advanced course Neurodegenerative Disorders, Program in Experimental Biology and Biomedicine (BEB), CNC (2019)
2008 - 2008 Co-organization of two advanced courses in Immunology, Ph.D. Program in Experimental Biology and Biomedicine (BEB), CNC (2008)
2006 - 2006 Co-organization of one advanced course in Neuroimmunology, Ph.D. Program in Experimental Biology and Biomedicine (BEB), CNC (2006)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020 Metabolic networks and metabolism in acute myeloid leucemia Olga Marisa da Silva Pereira (PhD)
Universidade do Minho, Portugal
2019 DESENVOLVIMENTO DE METODOLOGIAS PARA O ESTUDO DA INFLUÊNCIA DA OXIDAÇÃO DE AMINOFOSOFOLIPIDOS NA RESPOSTA IMUNE Simone Colombo (PhD)
Universidade de Aveiro, Portugal
2018 High value-added products from macroalgae: lipids as bioactive compounds Elisabete Valente da Costa (PhD)
2017 Preclinical performance of vaginal semisolid products: technological and safety evaluations assuming physiologic parameters Rita Solange Machado (PhD)
Universidade da Beira Interior, Portugal
2017 Towards an Efficient Filtration and Characterization of Airborne Nanoparticles Rita Joana Vaz dos Santos (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 Analytical Strategies based on mass spectrometry toward identifying nitro oxidative modifications in phospholipids Tânia Sofia Rodrigues de Melo (PhD)
Universidade de Aveiro, Portugal
2016 FRAGARIA VESCA LEAF AS A SOURCE OF BIOACTIVE PHYTOCHEMICALS - A FOCUS ON ELLAGITANNINS AND THEIR HUMAN MICROFLORA METABOLITES Joana Manuela Torres Liberal (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015 Adjuvant nanocarriers for hepatitis B vaccine: formulation design and mechanistic studies Sandra Cristina de Jesus (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014 Structural Characterization and Biological Activity of Polysaccharides from infusions used in popular tradition Vitor Manuel Ramalheira Martins (PhD)
Universidade de Aveiro, Portugal
2014 Oxidação e glicoxidação da fosfatidilserina e os seus efeitos na resposta imune: uma abordagem lipidómica Maria Elisabete Maciel (PhD)
Universidade de Aveiro, Portugal
2014 Glucose sensing and modulation of human chondrocyte functions by hyperglycemia: relevance as pharmacological targets for diabetes-associated OA Ana Teresa Rufino (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014 Cellular and molecular mechanisms of impaired wound healing in diabetes: understanding the role of substance P and mast cells Ana Luísa Tellechea (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 Efeito da própolis e de compostos isolados sobre a expressão de receptores, produção de citocinas e atividade fungicida de monócitos humanos Michelle Cristiane Bufalo (PhD)
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Botucatu, Brazil
2013 Geoprópolis de Melipona fasciculata Smith: ações citotóxica, imunomoduladora, antibacteriana e antifúngica Maria José Abigail Mendes Araújo (PhD)
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Botucatu, Brazil
2013 Drug Discovery of new anti-inflammatory phytochemicals using in vitro bio-guided assays: the case study of Cymbopogun citratus Vera Lúcia Francisco (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012 Portuguese Lavanders: evaluation of their potential use for health and agricultural purposes Mónica da Rocha Zuzarte (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 Genetic imbalances and numerical chromossomal alterations in glioblastomas as assessed by single-nucleotide polymorphism (SNP)-arrays and their impacto n gene expression Ana Inês Rebelo Crespo (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 Intratumoral Genetic Heterogeneity of Gliomas as assessed by combined interphase FISH and cDNA micro-arrays: impact on the clinical and biological behavior of the disease Ana Luísa Vital Castanheira de Carvalho (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 CYMBOPOGON CITRATUS COMPOSIÇÃO FENÓLICA E ACTIVIDADE ANTI-INFLAMATÓRIA Artur Manuel Machado Figueirinha (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 Identification of cellular and molecular markers selectively activated by skin sensitizers in dendritic cells Bruno Miguel Neves (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 Alergias do Tracto Respiratório Rinite Alérgica/Asma Lara Sofia Bolota Fonseca Alves Correia Machado (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 Reações de hipersensibilidade do aparelho respiratório Maria Luísa Pinto Ferreira (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 Condrócitos Susana Carvalho Rosa (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 Avaliação do perfil lipídico de células dendríticas imaturas e maduras Diana Marques (Master)
Universidade de Aveiro, Portugal
2010 Neuropeptides and skin inflammation Lucília Santos (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 Thymbra Capitata (L.) Cav. Waste Materials as a Resource of Bioactive Polyphenols Marta Geraldes Dias (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 Profiling changes triggered during dendritic cells maturation: a lipidomic approach Diana Raphaela Marques (Master)
Universidade de Aveiro, Portugal
2010 Neuropeptides and skin inflammation Lucília Santos (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 Modulation of dendritic cells function by Leishmania excreted/secreted antigens
(Thesis) Arguer
 Mariana Resende (Master)
Universidade do Porto, Portugal
2009 Screening e identificação de inibidores naturais da produção de NO e da activação do NF-kB, induzidas pela Interleucina-1beta,em condrócitos humanos
(Thesis) Arguer
 Ângela Neves (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2008 Neuropeptídeo Y e os seus receptores na retina: da proliferação Celular à Neuroprotecção Ana Rita da Costa e Silva Álvaro (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2007 Alterações induzidas pelo sensibilizador químico DNFB em células dendríticas da pele: regulação das MAPK, da libertação de IL-1¿ e de receptores membranares Maria Teresa de Jesus Matos (PhD)

Association member

Society Organization name Role
2020/02/04 - Current Sociedade Portuguesa de Imunologia
2017/04/06 - Current European Registered Toxicologist
2015/06/03 - Current Associação Portuguesa de Toxicologia (APTox)
2014/03/06 - Current Sociedade Portuguesa de Farmacologia
1992/02/06 - Current Ordem dos Farmacêuticos

Committee member

Activity description
Role 		Institution / Organization
2020/03/06 - Current Involvement in the adaptation of a Biosafety level 3 laboratory at the University of Coimbra for the diagnostic of the novel coronavirus, SARS-Coronavirus-2 (SARS-CoV-2), which is currently performing about 400 tests per day.
Coordinator
 Universidade de Coimbra, Portugal
2020/01/02 - Current 2ª vogal do Conselho de Administração da Associação UC Tecnimede
Member
 Universidade de Coimbra, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2017 - 2017 Member of the evaluation panel of scientific projects in the areas of Cellular and Molecular Biology and Immunology
Evaluator
 National Center of Science and Technology Evaluation Ministry of Education and Science Republic of Kazakhstan, Kazakhstan, Kazakhstan
2015 - 2015 Member of the evaluationpanel of scientific projects inthe areas of Cellular and Molecular Biology and Immunology
Evaluator
 National Center of Science and Technology Evaluation Ministry of Education and Science Republic of Kazakhstan, Kazakhstan, Kazakhstan
2013 - 2013 Avaliadora de bolsas FCT (doutoramento)
Evaluator
2013 - 2013 Avaliadora de projetos no âmbito do concurso Arrisca Coimbra - Concurso de Planos de Negócio, DITS
Evaluator

Journal scientific committee

Journal title (ISSN) Publisher
2018 - Current Evidence-based Complementary and Alternative Medicine (1741-4288) Hindawi Limited
2016/03/06 - Current Scientific Reports (2045-2322) Springer Science and Business Media LLC
2019 - 2019 Frontiers in Physiology (1664-042X) Frontiers Media SA
2019 - 2019 Pharmaceutics (1999-4923) MDPI AG

Legal proceeding

Activity description Case
2017/02/03 - Current Establishement of the UC / Tecnimede Cell Therapy pilot laboratory. This pilot laboratory aims to provide the region center with infrastructures that will enable it to take the lead of Cellular Therapy in Portugal. To obtain Good Manufacturing Practice ( GMP) for handling cellular products for clinical application

Mentoring / Tutoring

Topic Student name
2019 - Current Allergens4AD-Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease Ana Silva
2012 - Current Electrophilic stress: molecular targets for skin sensitizers Sofia Guedes
Distinctions

Award

2018 The best poster in basic research
European Society of Contact Dermatitis, Germany

Other distinction

2018 Melhor trabalho apresentado na área de Investigação Básica, no décimo quarto Congresso da Sociedade Europeia de Dermatite de Contacto, realizado em Milão, Itália,
2018 ImmunoTools Special Award para o projeto de doutoramento do aluno João Calmeiro
2013 Prémio de inovação e empreendedorismo
2012 Regional Business Ideas Competition
2011 BOLSAS DE IGNIÇÃO para o projecto “Detecção do potencial sensibilizador cutâneo de químicos”.
2011 Idea to Product
Fundación Cotec, Spain
2010 Prémio “Igualdade” - do Concurso de Ideias de Negócio Arrisca Coimbra '10 com o projecto “Teste in vitro para detecção do potencial alérgico cutâneo de químicos: uma imposição da nova legislação europeia” .
2008 Melhor poster na area de investigaçao basica e clinica
2008 “Prix de Recherche Sientific Lierac”
1993 Mellhor classificação na licenciaturado do Ramo A (Farmácia de Oficina e Hospitalar)
Ordem dos Farmaceuticos, Portugal