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Identification

Personal identification

Full name
Guillem Hernandez Gras

Citation names

  • Hernandez, Guillem

Author identifiers

Ciência ID
611C-6209-D3CB
ORCID iD
0000-0003-4438-5611

Email addresses

  • guillem.hernandez@itqb.unl.pt (Professional)

Addresses

  • Rua da Bempostinha 21 5DT, 1150-065, Lisboa, Lisboa, Portugal (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biophysics
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Catalan (Mother tongue)
Spanish; Castilian (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2019/02 - 2023/12
Concluded
 PhD in Molecular Biosciences (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Structure and Dynamics of Pathogenic Scaffold Proteins" (THESIS/DISSERTATION)
2016/09 - 2017/06
Concluded
 Master Universitari en Química Orgànica (Mestrado)
Universitat de Barcelona Facultat de Química, Spain
"Synthesis of JANUS base PNA monomer and its application to molecular recognition of U·U mismatched base pairs" (THESIS/DISSERTATION)
 8.3/10 ; 17/20
2011/09 - 2016/07
Concluded
 Grau en Química (Graduado)
Universitat de Barcelona Facultat de Química, Spain
"Synthesis of new polynuclear gold(I) compounds: study of application as sensors and potential luminescent hydrogels" (THESIS/DISSERTATION)
 7/10 ; 14/20
Affiliation

Science

Category
Host institution 		Employer
2019/02 - 2023/06/15 Research Trainee (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
(...)
2018/04 - 2019/02 Contracted Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/09 - 2017/07 Research Trainee (Research) Universitat de Barcelona Facultat de Química, Spain
Universitat de Barcelona Facultat de Química, Spain
(...)
2016/03 - 2016/08 Research Trainee (Research) Universitat de Barcelona Facultat de Química, Spain
Universitat de Barcelona Facultat de Química, Spain
(...)
2015/09 - 2016/02 Research Trainee (Research) Universitat de Barcelona Facultat de Química, Spain
Universitat de Barcelona Facultat de Química, Spain
(...)
Projects

Grant

Designation Funders
2022/01/01 - Current HUBs: The architecture of a pathogen-driven signailing hub
PTDC/BIA-BFS/0391/2021
PhD Student Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Ongoing
Outputs

Publications

Conference abstract
  1. Vieira, Marta; Hernandez, Guillem; Veloso, Tiago; Cordeiro, TN. "THE DISORDERED INTRACELLULAR SIDE OF THE TRANSLOCATED INTIMIN RECEPTOR". Paper presented in EUROMAR 2020, Bilbao, 2020.
    Published
  2. Bruno Salgueiro; Filipe Folgosa; Célia V. Romão; Hernandez, Guillem; Cordeiro, TN; Carlos Frazão; Miguel Teixeira. "Biochemical and structural characterization of a new Flavorubredoxin from Photobacterium swingsii". Paper presented in BioMetals 2020 - 12th International Biometals Web-Symposium, Grenoble, 2020.
    Published
Conference poster
  1. Lança Martins, Maria; Hernandez, Guillem; Brissos, Vânia; Martins, Lígia O.; Cordeiro, TN. Corresponding author: Cordeiro, TN. "A Hybrid-NMR Approach to Study Substrate Binding in directed evolution". Paper presented in Instruct Biennial Structural Biology, Cascais, Lisbon Portugal, 23 – 24 May 2024, 2024.
  2. Hernandez, Guillem; Lança Martins, Maria; Fernandes, Nuno P.; Veloso, Tiago; Castro, Laura Jesus; GOMES, TIAGO; Cordeiro, TN. Corresponding author: Cordeiro, TN. "Elucidating the conformational landscape and oligomerization pathways of the SARS-CoV-2 Nucleocapsid Protein through modelling and construct diversity". Paper presented in Instruct Biennial Structural Biology, Cascais, Lisbon Portugal, 23 – 24 May 2024, 2024.
  3. GOMES, TIAGO; Pau Martin-Malpartida; Hernandez, Guillem; Ruiz, Lidia; Veloso, Tiago; Lopes, João; Aragón, Eric; et al. "Integrative structural biology of full-length, flexible and oligomeric multidomain proteins involved in pathogenicity". Paper presented in EMBO Workshop - Proteostasis: From translation to degradation, 2023.
  4. Martins, Maria; Hernandez, Guillem; Brissos, Vânia; Martins, Lígia; Cordeiro, TN. "NMR Studies of Transient Enzyme-Substrate Interactions". Paper presented in TIMB3 Final Meeting, 2022.
  5. Hernandez, Guillem; Vieira, Marta; Veloso, Tiago; Martins, Maria; Cordeiro, TN. "Diving into the structure of the N-Terminal intracellular domain of Tir". Paper presented in 11th PhD Meeting at ITQB, 2021.
  6. Vieira, Marta; Veloso, Tiago; Hernandez, Guillem; Cordeiro, TN. "Dissecting the C-Terminus region of Tir bacterial weapon at residue level". Paper presented in 10th PhD Meeting at ITQB, 2020.
  7. Vieira, Marta; Monteiro, Hugo; Hernandez, Guillem; Veloso, Tiago; Cordeiro, TN. "Ensemble characterization of the C-Terminal Region of Tir: one step closer to solve a disordered puzzle". Paper presented in Twin to Illuminate Metals in Biology and Biocatalysis through Biospectroscopy (TIMB3), 2019.
  8. Hernandez, Guillem; Vieira, Marta; Monteiro, Hugo; Salgueiro, Bruno; Frazão, Carlos; Cordeiro, TN. "Dissecting the Structure of the N-Terminal Cytosolic Tail of the Translocated Intimin Receptor". Paper presented in 2019 PT NMR Satellite Meeting to SMASH, 2019.
  9. Salgueiro, Bruno; Ribeiro, Ricardo; Romão, Célia; Hernandez, Guillem; Cordeiro, Tiago; Sá-Correia, Isabel; Frazão, Carlos. "Haa1 transcription factor DNA binding domain structural analysis of two homologous proteins". Paper presented in 1º Encontro Nacional de Cristalografia - Aveiro, 2019.
  10. Salgueiro, Bruno; Ribeiro, R.; Romão, C.V.; Hernandez, Guillem; Cordeiro, TN; Sá-Correia, I; Frazão, Carlos. "Haa1 transcription fator DNA binding domain structural analysis of two homologous proteins". Paper presented in I National Crystallography Meeting, 2019.
  11. Monteiro, Hugo; Vieira, Marta; Hernandez, Guillem; González, Amaia; Borges, Patrícia; Frazão, Carlos; Monza, Emanuele; et al. "Dynamic Strucutral Studies – From Pathogenic Disordered Proteins To Folded Relevant Enzymes". Paper presented in Twin to Illuminate Metals in Biology and Biocatalysis through Biospectroscopy (TIMB3), 2018.
  12. Monteiro, Hugo; Vieira, Marta; Hernandez, Guillem; Cordeiro, TN. "The virulent effector Tir: getting structural and dynamics insights through SAXS and Molecular Modelling". Paper presented in Lisbon Biophysics Meeting Meeting, 2018.
Journal article
  1. Vieira, Marta; Hernandez, Guillem; Zhong, Qiyun; Arbesú, Miguel; Veloso, Tiago; GOMES, TIAGO; Lança Martins, Maria; et al. "The pathogen-encoded signalling receptor Tir exploits host-like intrinsic disorder for infection". Communications Biology (2024):
    Accepted
  2. Bárria, Cátia; Athayde, Diogo; Hernandez, Guillem; Fonseca, Leonor; Casinhas, Jorge; Cordeiro, Tiago N.; Archer, Margarida; et al. "Structure and function of Campylobacter jejuni polynucleotide phosphorylase (PNPase): Insights into the role of this RNase in pathogenicity". Biochimie 216 (2024): 56-70. http://dx.doi.org/10.1016/j.biochi.2023.10.006.
    10.1016/j.biochi.2023.10.006
  3. Marini, Eleonora; Olivença, Carmen; Ramalhete, Sara; Aguirre, Andrea Martinez; Ingle, Patrick; Melo, Manuel N.; Antunes, Wilson; et al. "A sporulation signature protease is required for assembly of the spore surface layers, germination and host colonization in Clostridioides difficile". PLOS Pathogens 19 11 (2023): e1011741. http://dx.doi.org/10.1371/journal.ppat.1011741.
    10.1371/journal.ppat.1011741
  4. Pinto, Daniela; Gonçalo, Raquel; Louro, Mariana; Silva, Marta Sousa; Hernandez, Guillem; Cordeiro, Tiago N.; Cordeiro, Carlos; São-José, Carlos. "On the Occurrence and Multimerization of Two-Polypeptide Phage Endolysins Encoded in Single Genes". Microbiology Spectrum 10 4 (2022): http://dx.doi.org/10.1128/spectrum.01037-22.
    Published • 10.1128/spectrum.01037-22
  5. Trindade, I. B.; Hernandez, G.; Lebègue, E.; Barrière, F.; Cordeiro, T.; Piccioli, M.; Louro, R. O.. "Conjuring up a ghost: structural and functional characterization of FhuF, a ferric siderophore reductase from E. coli". JBIC Journal of Biological Inorganic Chemistry (2021): http://dx.doi.org/10.1007/s00775-021-01854-y.
    Published • 10.1007/s00775-021-01854-y
  6. Borges, Patrícia T.; Brissos, Vânia; Hernandez, Guillem; Masgrau, Laura; Lucas, Maria Fátima; Monza, Emanuele; Frazão, Carlos; Cordeiro, Tiago N.; Martins, Lígia O.. "Methionine-Rich Loop of Multicopper Oxidase McoA Follows Open-to-Close Transitions with a Role in Enzyme Catalysis". ACS Catalysis 10 13 (2020): 7162-7176. http://dx.doi.org/10.1021/acscatal.0c01623.
    Published • 10.1021/acscatal.0c01623
  7. Fernandes, Catarina G.; Martins, Diogo; Hernandez, Guillem; Sousa, Ana L.; Freitas, Carolina; Tranfield, Erin M.; Cordeiro, TN; et al. "Temporal and spatial regulation of protein cross-linking by the pre-assembled substrates of a Bacillus subtilis spore coat transglutaminase". PLOS Genetics 15 4 (2019): e1007912. http://dx.doi.org/10.1371/journal.pgen.1007912.
    Accepted • 10.1371/journal.pgen.1007912
  8. Pinto, Andrea; Hernandez, Guillem; Gavara, Raquel; Aguiló, Elisabet; Moro, Artur J.; Aullón, Gabriel; Malfois, Marc; Lima, João Carlos; Rodríguez, Laura. "Supramolecular tripodal Au(i) assemblies in water. Interactions with a pyrene fluorescent probe". New Journal of Chemistry 43 21 (2019): 8279-8289. http://dx.doi.org/10.1039/c9nj00469f.
    Accepted • 10.1039/c9nj00469f
Thesis / Dissertation
  1. "Structure and Dynamics of Pathogenic Scaffold Proteins". PhD, Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, 2023. https://run.unl.pt/handle/10362/163109.
  2. Hernandez, Guillem. "Synthesis of JANUS base PNA monomer and its application to molecular recognition of U·U mismatched base pairs.". Master, Universitat de Barcelona Departament de Química Orgànica, 2017. http://www.qo.ub.edu/masterqo/data/tfm/data/2016-17/data/TFM2016_Hernandez_Gras_Guillem.memoria.pdf.
  3. Hernandez, Guillem. "Synthesis of new polynuclear gold(I) compounds: study of application as sensors and potential luminescent hydrogels". Degree, Universitat de Barcelona Departament de Química Inorgànica, 2016. https://www.ub.edu/portal/documents/1749702/4538327/Hernandez_Gras_Guillem_summary.pdf/3155cf75-f6c5-42c6-abe3-7dddc79d4e8d.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/05/31 Structure and Dynamics of Pathogenic Scaffold Proteins
Instituto de Tecnologia Química e Biologica - Universidade Nova de Lisboa (Oeiras, Portugal)
2017/01 Au(I)Supramolecular System As A Potential Sensor of Pyrene II Workshop on Chemistry of Group 11 Elements
Univesitat de Barcelona (Barcelona, Spain)

Committee member

Activity description
Role 		Institution / Organization
2019/11 - Current Gender Equality WorkGroup at ITQB
Member
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Mentoring / Tutoring

Topic Student name
2023/04/01 - Current Mentoring - Bench Guidance - Post-master fellow André Meireis
2022/10/01 - 2023/04/30 Mentoring - Bench Guidance - Post-master fellow Laura Castro
2022/02/01 - 2022/06 Mentoring - Bench Guidance - Undergrade thesis Joao Lopes
2021/02 - 2022/03 Mentoring - Bench guidance - Master thesis Maria Martins