| Conference poster |
- João S Gonçalves; Raquel M. Seiça; João Laranjinha; Cátia F. Lourenço. "Neurovascular coupling and spatial memory are modulated
by nitrate in a rat model of diabetes". Paper presented in BRAIN & BRAIN PET 2022 (accepted - TBD), 2022.
- João S Gonçalves; Raquel M. Seiça; João Laranjinha; Cátia F. Lourenço. "Impairment of neurovascular coupling and spatial memory
in a rodent model of type 2 diabetes: impact of dietary nitrate intervention". Paper presented in XVII Meeting of the Portuguese
Society for Neuroscience, 2021.
- Reva, Katerina; João S Gonçalves; Ana Raquel Santiago; João Laranjinha; Cátia F Lourenço. "Dietary nitrate, a metabolic precursor
of nitric oxide, mitigates diabetic retinopathy in a type 2 diabetes rodent model". Paper presented in V Symposium of Portuguese
Glial Network, 2021.
- Katerina Reva; Ana Raquel Santiago; João Laranjinha; Cátia F Lourenço. "Spatial navigation improvement induced by dietary
nitrate in a chronic cerebral hypoperfusion rodent model is independent of visual function status.". Paper presented in no
XVII Meeting of the Portuguese Society for Neuroscience, 2021.
- Cátia F. Lourenço; João S. Gonçalves; José Sereno; João Sargento-Freitas; Castelo-Branco, Miguel; João Laranjinha. "Disruption
of neurovascular coupling in a rodent model of vascular dementia – can we rescue it by nitrate supplementation?". Paper presented
in 20th Biennial Meeting of SFRR International SFRR-I 2021, 2021.
- Ledo, A.; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Tracking neurometabolic markers during seizure activity
in awake rodents". Paper presented in Neuroscience 2019 - Chicago, 2019.
- Gonçalves, J.S,.; Lourenço, C.F.; Laranjinha, J.. "The nitrate-nitrite-nitric oxide pathway as rescuing mechanisms of cerebral
dysfunction in a rodent model of vascular dementia". Paper presented in SFRR-E Meeting Ferrara 2019 (Ferrara, Italy),
2019.
- Barbosa, R.M.; Lourenço, C.F.; Nunes, C.; Manaia, M.; Ferreira, N.R.; Laranjinha, J.; Ledo, A.. "Monitoring Hydrogen Peroxide
in Biological Media: Electrochemical Sensing Approaches". Paper presented in SFRR-E Meeting Ferrara 2019 (Ferrara, Italy),
2019.
- Dias, C.; Lourenço, C.F.; Barbosa, R.M.; Ledo, A.; Laranjinha, J.. "Nitrite modulates mitochondrial respiration in brain ischemia/reperfusion".
Paper presented in SFRR-E FERRARA MEETING 2019 (Ferrara, Italy), 2019.
- Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Aberrant changes in oxygen levels in the brain during
Seizures in awake freely behaving rodents.". Paper presented in Europhysiology 2018 (London, UK), 2018.
- Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Simultaneous recording of neurometabolic changes
and local field potential in central nervous system in awake behaving rodent models of epilepsy". Paper presented in 11th
FENS Forum of Neuroscience (Berlin, Germany), 2018.
- Ledo, A.; Lourenço, C.F.; Nunes, C.; Santos, D.; Barbosa, R.M.. "Electrochemical (bio)sensors for high-resolution measurements
of hydrogen peroxide in biological media". Paper presented in 19th SFRRI Biennial Meeting (Lisboa, Portugal), 2018.
- Dias, C.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Age-dependent impairment of the glutamate-nitric oxide
pathway in the hippocampus of the triple transgenic mouse model of Alzheimer's disease". Paper presented in 19th SFRRI
Biennial Meeting (Lisboa, Portugal), 2018.
- Dias, C.; Monteiro, T.; Lourenço, C.F.; Ledo, A.; Almeida, M.G.; Laranjinha, J.; Barbosa, R.M.. "Probing nitrite and nitric
oxide biochemistry in the brain in vivo by a novel sensing approach.". Paper presented in Joint meeting of the International
Society of Neurochemistry and the European Society for Neurochemistry (Paris, France), 2017.
- Barbosa, R.M.; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Ledo, A.. "Monitoring neurometabolic markers in vivo with electrochemical
microsensor arrays". Paper presented in 68th Annual Meeting of the International Society of Electrochemistry. (Providencia,
USA)., 2017.
- Monteiro, T.; Dias, C.; Lourenço, C.F.; Ledo, A.; Almeida, G.. "Micro(bio)sensing tools for nitrite detection in the brain.".
Paper presented in International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society (Lion,
France), 2017.
- Lourenço, C.F.; Ledo, A.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Alterations in the glutamate-nitric oxide pathway
in the hippocampus of the triple transgenic model of Alzheimer’s disease are age-dependent and affect neurometabolic regulation".
Paper presented in XIX National Congress of Biochemistry (Guimarães, Portugal), 2016.
- Huettl, P.; Ledo, A.; Lourenço, C.F.; Hampson, R.E.; Deadwyler, S.A.; Laranjinha, J.; Barbosa, R.M.; Gerhardt, G.A.. "Optimising
biomorphic microelectrode arrays for electrophysiological and neurochemical recordings". Paper presented in Neuroscience
2016, Society for Neuroscience (San Diego, USA), 2016.
- Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Huettl, P.; Pomerleau, F.; Barbosa, R.M.; Gerhardt, G.A.. "Simultaneous recording
of neurometabolic changes and local field potential-related currents in rodent models of Epilepsy.". Paper presented in Neuroscience
2016 (San Diego, USA)., 2016.
- Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Monitoring metabolic changes in the central nervous
system of awake behaving rodent models of epilepsy". Paper presented in Monitoring Molecules in Neuroscience 2016,
2016.
- Ledo, A.; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Neurometabolic Coupling: from Glutamate Neurotransmission
to Oxygen and Glucose. Enzyme-Modified Microelectrodes for Monitoring Neurochemicals In Vivo.". Paper presented in 9th
World Congress International Brain Research Organization (Rio de Janeiro, Brazil), 2015.
- Laranjinha, J.; Lourenço, C.F.; Ferreira, N.R.. "Nitric oxide-mediated neurovascular coupling in Alzheimer disease and under
metabolic acidosis.". Paper presented in European Society for Neurochemistry's Conference (Tartu, Estonia), 2015.
- Barbosa, R.M.; Ledo, A.; Lourenço, C.F.; Ferreira, N.R.; Gerhardt, G.A.; Laranjinha, J.. "Microelectrode-based sensors and
biosensors for high resolution measurements of neurochemicals in the brain". Paper presented in n Oxygen Club of California
World Congress 2015 Oxidants and Antioxidants in Biology (Valencia, Spain), 2015.
- Ledo, A.; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Neurometabolic Changes in the Central Nervous System
of Awake Behaving Rodent Models of Epilepsy.". Paper presented in Oxygen Club of California World Congress 2015 Oxidants
and Antioxidants in Biology (Valencia, Spain), 2015.
- Dias, C.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Age-dependent changes in the NMDAr-NO pathway in the hippocampus
of a triple transgenic mouse model of Alzheimer´s disease: implications for neurometabolic regulation". Paper presented in
In Oxygen Club of California World Congress 2015 Oxidants and Antioxidants in Biology (Valencia, Spain), 2015.
- Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Derailment in nitric oxide-dependent neurovascular and neurometabolic
coupling in aging". Paper presented in XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function.,
2015.
- Lourenço, C.F.; Ledo, A.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Oxidase-based microbiosensor for real time monitoring
of glucose and neuronal activity in awake behaving animals". Paper presented in XXVIIth International Symposium on Cerebral
Blood Flow, Metabolism and Function., 2015.
- Barbosa, R.M.; Lourenço, C.F.; Ledo, A.; Caetano, M.; Ferreira, N.R.; Gerhardt, G.A.; Laranjinha, J.. "Design of implantable
enzyme-based microelectrodes for real-time measurements of neurochemicals and metabolic markers in vivo in the rat brain.".
Paper presented in 4th International Conference on Bio-Sensing Technology (Lisboa, Portugal), 2015.
- Miranda, S.; Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "The fluctuations of nitric oxide and O2 in rat hippocampus
with functional implications for neurometabolism". Paper presented in XVIII Congress of the Portuguese Biochemical Society
(Coimbra, Portugal), 2014.
- Ferreira, N.R.; Lourenço, C.F.; Costa, S.M.; Barbosa, R.M.; Laranjinha, J.. "Nitrite is a precursor of nitric oxide in the
brain hippocampus of living animals via redox interaction with ascorbate. An in vivo study in real-time.". Paper presented
in In XVIII Congress of the Portuguese Biochemical (Coimbra, Portugal), 2014.
- Ledo, A.; Lourenço, C.F.; Caetano, M.; Barbosa, R.M.; Laranjinha, J.. "The glutamate-nNOS-nitric oxide pathway is impaired
in aging. An in vivo study in Fisher 344 rats.". Paper presented in XVIII Congress of the Portuguese Biochemical Society
(Coimbra, Portugal), 2014.
- Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Impaired nitric oxide-mediated neurovascular coupling is an early
functional deficiency in Alzheimer’s disease: an in vivo study in a rodent model.". Paper presented in XVIII Congress of
the Portuguese Biochemical Society (Coimbra, Portugal), 2014.
- Ferreira, N.R.; Lourenço, C.F.; Costa, S.A.; Laranjinha, J.; Barbosa, R.M.. "Simultaneous Measurements of Ascorbate and Glutamate
In Vivo in the Rat Brain.". Paper presented in 65th Annual meeting of the International Society of Electrochemistry (Lausanne,
Switzerland), 2014.
- Caetano, M; Lourenço, C.F.; Santos, R.M.; Laranjinha, J.; Barbosa, R.M.. "Development of Carbon Fiber Microelectrode-Based
Biosensor for Glucose Measurement In Vivo in the Brain.". Paper presented in Symposium of the Analytical Division of SPQ
(Coimbra, Portugal), 2014.
- Lourenço, C.F.; Davis, V.A.; Batten, S.R.; Quintero, G.; Pormeleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.; Barbosa,
R.M.. "Teasing apart Nitric Oxide’s role in erection: how hard can it be?". Paper presented in Neuroscience 2013 (San Diego,
USA), 2013.
- Ferreira, N.R.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.. "The redox interplay between nitrite, ascorbate and nitric
oxide in the brain". Paper presented in XIII meeting of the Portuguese Society for Neurosciences (Luso, Portugal),
2013.
- Lourenço, C.F.; Caetano, M; Ledo, A.; Laranjinha, J.; Barbosa, R.M.. "Matching oxygen and glucose dynamics during neurovascular
coupling in rat hippocampus". Paper presented in XIII meeting of the Portuguese Society for Neurosciences (Luso, Portugal),
2013.
- Lourenço, C.F.; Barbosa, R.M.; Cadenas, E.; Rafael Radi; Laranjinha, J.. "Neuronal-nitric oxide dynamics and coupled neurovascular
coupling in Alzheimer Disease and Aging.". Paper presented in Gordon Research Conference on Oxidative Stress and Disease
(Les Diablerets, Switzerland), 2013.
- Ferreira, N.R; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.. "Nitric oxide bridges glutamatergic activity and ascorbate release
to the extracellular space in the rat hippocampus". Paper presented in Conference Monitoring Molecules in Neuroscience
(London, UK), 2012.
- Santos, R.M; Lourenço, C.F.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M. "Nitric Oxide and L-Glutamate Concentration Profiles
in the Rat Hippocampus: Temporal and Spatial Relationship". Paper presented in Neuroscience 2011 (Washington, USA),
2011.
- Laranjinha, J.; Lourenço, C.F.; Cadenas, E.; Radi, R.; Barbosa, R.M.. "Neurovascular coupling in Alzheimer´s disease: in vivo
and real-time measurement of nitric oxide and cerebral blood flow.". Paper presented in 23rd Biennial Meeting of ISN-ESN
(Athens, Greece), 2011.
- Lourenço, C.F.; Laranjinha, J.; Cadenas, E.; Radi, R.; Barbosa, R.M.. "Brain microcirculation is regulated by neuronal-derived
nitric oxide: real time and in vivo demonstration". Paper presented in Annual Meeting of the Physiological Society, Physiology
2011 (Oxford, UK), 2011.
- Lourenço, C.F.; Santos, R.M.; Barbosa, R.M.; Cadenas, E.; Laranjinha, J.. "Nitric oxide dynamics couples neuronal activity
with hippocampus microcirculation: a mechanism impaired in a triple-transgenic mouse model of Alzheimer disease". Paper presented
in XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function (Barcelona, Spain), 2011.
- Lourenço, C.F.. "Assessing Nitric Oxide Diffusion in the Brain: How diffusible is this messenger". Paper presented in XVII
Congresso Nacional de Bioquímica (Porto, Portugal), 2010.
- Nuno Ricardo Ferreira; Lourenço, C.F.; Ricardo Miguel Santos; Ana Ledo; João António Nave Laranjinha; Rui Manuel Silva Barbosa.
"In Vivo Monitoring of Nitric Oxide in the Rat Brain: Characterization of a Carbon Fiber Microelectrode Based Probe". Paper
presented in XVII Congresso Nacional de Bioquímica (Porto, Portugal), 2010.
- Lourenço, C.F.; Ricardo Miguel Santos; Rafael Radi; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "Neurovascular
coupling in hippocampus of a triple-transgenic mouse model of Alzheimer disease.". Paper presented in XVII Congresso Nacional
de Bioquímica (Porto, Portugal), 2010.
- Ricardo Miguel Santos; Lourenço, C.F.; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Experimental
Evidence for a Facilitated Nitric Oxide Diffusion In Vivo in the Brain". Paper presented in Neuroscience 2010, San Diego,
Estados Unidos da América, 2010.
- Lourenço, C.F.; Ricardo Miguel Santos; Rafael Radi; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "Nitric oxide
in rat hippocampus: is a free radical the key of neurovascular coupling?". Paper presented in International Symposium on
the Pathophysiology of Reactive Oxygen and Nitrogen Species, 2010.
- Lourenço, C.F.; Ricardo Miguel Santos; Rafael Radi; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "Probing neurovascular
coupling in the hippocampus using an array of nitric oxide microelectrode and a laser Doppler probe". Paper presented in 13th
International Conference on In Vivo Methods, 2010.
- Rui Manuel Silva Barbosa; Ricardo Miguel Santos; Lourenço, C.F.; Ana Ledo; Greg A. Gerhardt; João António Nave Laranjinha.
"Nanocomposite-modified Microelectrodes for Nitric Oxide Monitoring in vivo in the rat brain.". Paper presented in 61st
Annual Meeting of the International Society of Electrochemistry- Electrochemistry from Biology to Physics, 2010.
- Mariano Redondo-Horcajo; Patrícia Martínez-Acedo; António Martínez-Ruiz; Cecilian Quijano; Lourenço, C.F.; N Movilla; JA Enriquez;
et al. "Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide". Paper
presented in International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species, 2010.
- Ricardo Miguel Santos; Lourenço, C.F.; Francois Pormeleau; Petter Huettl; Greg A. Gerhardt; João António Nave Laranjinha;
Rui Manuel Silva Barbosa. "Nitric oxide inactivation in the central nervous system is governed by the vasculature". Paper
presented in International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species, 2010.
- João António Nave Laranjinha; Lourenço, C.F.; Rafael Radi; Rui Manuel Silva Barbosa. "Neurovascular coupling between neuronal
activity and blood flow in hippocampus mediated by nitric oxide". Paper presented in 4th European Society for Neurochemistry
Conference on Advances in Molecular Mechanisms of Neurological Disorders, 2009.
- Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "In vivo
concentration dynamics of nitric oxide in hippocampus and striatum of anesthetized rat following activation of glutamate receptors".
Paper presented in 4th European Society for Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological
Disorders, 2009.
- Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "In Vivo
inactivation of nitric oxide in the rat CNS: Quantitative and mechanistic features". Paper presented in 11th Meeting of
the Portuguese Society for Neuroscience., 2009.
- Lourenço, C.F.; Ricardo Miguel Santos; Rafael Radi; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "Nitric oxide
mediates the neurovascular coupling between neuronal activity and blood flow in rat hippocampus: in vivo and direct evidence".
Paper presented in 11th Meeting of the Portuguese Society for Neuroscience, 2009.
- Rui Manuel Silva Barbosa; Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; João António Nave Laranjinha. "In vivo
Inactivation of nitric oxide in CNS". Paper presented in 4th European Society for Neurochemistry Conference on Advances
in Molecular Mechanisms of Neurological Disorders, 2009.
- Rui Manuel Silva Barbosa; Lourenço, C.F.; Ricardo Miguel Santos; Francois Pormeleau; Petter Huettl; Greg A. Gerhardt; João
António Nave Laranjinha. "In Vivo Real Time Measurement of Nitric Oxide in Anesthetized Rat Brain". Paper presented in 59th
Annual Meeting of the International Society of Electrochemistry., 2008.
- Ricardo Miguel Santos; Lourenço, C.F.; Ana Piedade; Roger Andrews; Francois Pormeleau; Petter Huettl; João António Nave Laranjinha;
Rui Manuel Silva Barbosa. "A Comparative Study of Carbon Fiber-Based Microelectrodes for the Measurement of Nitric Oxide in
Brain Tissues". Paper presented in The 59th Annual Meeting of the International Society of Electrochemistry., 2008.
- Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "In vivo
concentration dynamics of nitric oxide in anesthetized rat brain.". Paper presented in SFRR-Europe Summer School 2008.,
2008.
- Ricardo Miguel Santos; Lourenço, C.F.; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "In vivo
real time kinetics of nitric oxide inactivation in the anesthetized rat brain". Paper presented in 6th Federation of European
Neuroscience Societies Forum, 2008.
- Lourenço, C.F.. "In vivo concentration dynamics of nitric oxide in anesthetized rat brain". Paper presented in Meeting
SFRR-Europe 2008, 2008.
- Lourenço, C.F.; Ricardo Miguel Santos; Greg A. Gerhardt; Rui Manuel Silva Barbosa; João António Nave Laranjinha. "P5. Regional
nitric oxide concentration dynamics in the hippocampus of living rats evoked by stimulation of the glutamate receptors". Paper
presented in Meeting SFRR-Europe 2007., 2007.
- Ricardo Miguel Santos; Lourenço, C.F.; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Real time
in vivo measurement of nitric oxide concentration dynamics in the rat hippocampus". Paper presented in Meeting SFRR-Europe
2007, 2007.
- Lourenço, C.F.; Ricardo Miguel Santos; Michel Stephens; Francois Pormeleau; Greg A. Gerhardt; João António Nave Laranjinha;
Rui Manuel Silva Barbosa. "Real time in vivo measurement of nitric oxide microelectrodes in the CA1 and CA3 regions in the
rat hippocampus.". Paper presented in 10th Meeting of the Portuguese Society for Neuroscience, 2007.
- Ricardo Miguel Santos; Lourenço, C.F.; Greg A. Gerhardt; João António Nave Laranjinha; Rui Manuel Silva Barbosa. "Carbon fiber
microelectrodes for in vivo electrochemical detection of neurochemicals". Paper presented in 6º Encontro da Divisão de
Química Analítica da Sociedade Portuguesa de Química., 2007.
- Lourenço, C.F.; Bruno Gago; Joana Martins; João António Nave Laranjinha. "Phenols from red wine and olive oil recycle vitamin
E in LDL particles, modulating its oxidizability in plasma". Paper presented in III Annual Meeting Center for Neurosciences
and Cell Biology, 2005.
- Maria de São José Nascimento; Pedro, M.; Lourenço, C.F.; Madalena Pinto; Cidade, H.; Kijjoa, A.. "The effect of natural prenylated
flavones on ER+ and ER- breast carcinoma cell lines.". Paper presented in Transmediterranean Colloquium on Heterocycle
Chemistry TRAMECH 2004, 2004.
|
| Journal article |
- Gonçalves, J.S,.; Laranjinha, J.; Rocha, B.S.; Lourenço, C.F.. "Dietary Nitrate Supplementation and Cognitive Health: the
nitric oxide-dependent neurovascular coupling hypothesis". Biochemical Society Transactions (2024):
Accepted
- Dias, C.; Lourenço, C.F.; Laranjinha, J.; Ledo, A.. "Modulation of oxidative neurometabolism in ischemia/reperfusion by nitrite".
Free Radical Biology and Medicine 193 (2022): 779-786. http://dx.doi.org/10.1016/j.freeradbiomed.2022.11.021.
10.1016/j.freeradbiomed.2022.11.021
- Gonçalves, João S.; Seiça, Raquel M.; Laranjinha, João; Lourenço, Cátia F.. "Impairment of neurovascular coupling in the hippocampus
due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats". Free Radical
Biology and Medicine 193 (2022): 669-675. http://dx.doi.org/10.1016/j.freeradbiomed.2022.11.009.
10.1016/j.freeradbiomed.2022.11.009
- Lourenço, Cátia F.; Laranjinha, João. "Nitric Oxide Pathways in Neurovascular Coupling Under Normal and Stress Conditions
in the Brain: Strategies to Rescue Aberrant Coupling and Improve Cerebral Blood Flow". Frontiers in Physiology 12 (2021):
http://dx.doi.org/10.3389/fphys.2021.729201.
10.3389/fphys.2021.729201
- Mancini, Gianni; Dias, Candida; Lourenço, Catia F.; Laranjinha, Joao; de Bem, Andreza; Ledo, Ana. "A High Fat/Cholesterol
Diet Recapitulates Some Alzheimer’s Disease-Like Features in Mice: Focus on Hippocampal Mitochondrial Dysfunction". Journal
of Alzheimer's Disease 82 4 (2021): 1619-1633. http://dx.doi.org/10.3233/jad-210122.
10.3233/jad-210122
- Monteiro, Tiago; Dias, Cândida; Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M.; Almeida, M. Gabriela. "Microelectrode Sensor
for Real-Time Measurements of Nitrite in the Living Brain, in the Presence of Ascorbate". Biosensors 11 8 (2021): 277.
http://dx.doi.org/10.3390/bios11080277.
10.3390/bios11080277
- Ledo, A; Lourenço, C.F.; Cadenas, E; Barbosa, R.M.; Laranjinha, J.. "The bioactivity of neuronal-derived nitric oxide in aging
and neurodegeneration: Switching signaling to degeneration". Free Radical Biology and Medicine (2020): http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.005.
10.1016/j.freeradbiomed.2020.11.005
- Laranjinha, J.; Nunes, C.; Ledo, A.; Lourenço, C.F.; Rocha, B.S.; Barbosa, R.M.. "The Peculiar Facets of Nitric Oxide as a
Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling".
Neurochemical Research (2020):
Published • 10.1007/s11064-020-03015-0
- Lourenço, Cátia F.; Caetano, Miguel; Ledo, Ana; Barbosa, Rui M.. "Platinized carbon fiber-based glucose microbiosensor designed
for metabolic studies in brain slices". Bioelectrochemistry 130 (2019): 107325. http://dx.doi.org/10.1016/j.bioelechem.2019.06.010.
10.1016/j.bioelechem.2019.06.010
- Ana Ledo; Cátia F. Lourenço; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa. "Concurrent measurements of neurochemical
and electrophysiological activity with microelectrode arrays: New perspectives for constant potential amperometry". Current
Opinion in Electrochemistry 12 (2018): 129-140. https://doi.org/10.1016/j.coelec.2018.05.018.
10.1016/j.coelec.2018.05.018
- Lourenço, Cátia F.; Ledo, Ana; Caetano, Miguel; Barbosa, Rui M.; Laranjinha, João. "Age-Dependent Impairment of Neurovascular
and Neurometabolic Coupling in the Hippocampus". Frontiers in Physiology 9 (2018): http://dx.doi.org/10.3389/fphys.2018.00913.
10.3389/fphys.2018.00913
- Dias, C.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Analysis of respiratory capacity in brain tissue preparations:
high-resolution respirometry for intact hippocampal slices". Analytical Biochemistry 551 (2018): 43-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047068802&partnerID=MN8TOARS.
10.1016/j.ab.2018.05.010
- Cátia F. Lourenço; Ana Ledo; Greg A. Gerhardt; João Laranjinha; Rui M. Barbosa. "Neurometabolic and electrophysiological changes
during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arrays". Scientific
Reports 7 1 (2017): https://doi.org/10.1038/s41598-017-07119-6.
10.1038/s41598-017-07119-6
- Ana Ledo; Cátia F. Lourenço; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa. "Combined in Vivo Amperometric Oximetry and
Electrophysiology in a Single Sensor: A Tool for Epilepsy Research". Analytical Chemistry (2017): https://doi.org/10.1021/acs.analchem.7b03452.
10.1021/acs.analchem.7b03452
- Ana Ledo; Cátia F. Lourenço; João Laranjinha; Christopher M. A. Brett; Greg A. Gerhardt; Rui M. Barbosa. "Ceramic-Based Multisite
Platinum Microelectrode Arrays: Morphological Characteristics and Electrochemical Performance for Extracellular Oxygen Measurements
in Brain Tissue". Analytical Chemistry 89 3 (2017): 1674-1683. https://doi.org/10.1021/acs.analchem.6b03772.
10.1021/acs.analchem.6b03772
- Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular uncoupling in the triple transgenic model of Alzheimer's
disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling". Experimental Neurology
291 (2017): 36-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011654048&partnerID=MN8TOARS.
10.1016/j.expneurol.2017.01.013
- Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular-neuroenergetic coupling axis in the brain: master
regulation by nitric oxide and consequences in aging and neurodegeneration". Free Radical Biology and Medicine 108
(2017): 668-682. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018262522&partnerID=MN8TOARS.
10.1016/j.freeradbiomed.2017.04.026
- Dias, C.; Lourenço, C.F.; Ferreiro, E.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Age-dependent changes in the glutamate-nitric
oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation".
Neurobiology of Aging 46 (2016): 84-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978903965&partnerID=MN8TOARS.
10.1016/j.neurobiolaging.2016.06.012
- Lourenço, C.F.; Ledo, A.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Microelectrode array biosensor for high-resolution
measurements of extracellular glucose in the brain". Sensors and Actuators, B: Chemical 237 (2016): 298-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976594136&partnerID=MN8TOARS.
10.1016/j.snb.2016.06.083
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