Daniela Madeira (6413-7DC1-BC87)

Curriculum Vitae

Daniela Madeira

Daniela Madeira. Completed the Mestrado in Investigação Biomédica in 2017/09/11 by Universidade de Coimbra Faculdade de Medicina and Licenciatura in Biologia Humana in 2014/07/04 by Universidade de Évora. Attends the Doutoramento in Ciências da Saúde by Universidade de Coimbra Faculdade de Medicina since 2018/09.

Identification

Personal identification

Full name: Daniela Madeira

Citation names

Madeira, Daniela

Author identifiers

Ciência ID: 6413-7DC1-BC87
ORCID iD: 0000-0002-6027-5407

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Upper intermediate (B2)	Advanced (C1)	Upper intermediate (B2)	Advanced (C1)	Upper intermediate (B2)

Education

	Degree	Classification
2018/09 - 2022/09 Ongoing	Ciências da Saúde (Doutoramento) Major in Neurociências Universidade de Coimbra Faculdade de Medicina, Portugal "Crosstalk entre recetores de adenosina A2A e conexina 43 na doença de Alzheimer" (THESIS/DISSERTATION)
2016/09/07 - 2017/09/11 Concluded	Investigação Biomédica (Mestrado) Major in Neurociências Universidade de Coimbra Faculdade de Medicina, Portugal "ATP and glutamate release by astrocytes under Alzheimer´s disease conditions: modulation by adenosine A2A receptors" (THESIS/DISSERTATION)	18
2011/09 - 2014/07/04 Concluded	Biologia Humana (Licenciatura) Universidade de Évora, Portugal "Allergen profile of soluble protein fraction of pollen from Quercus rotundifolia" (THESIS/DISSERTATION)	16

Projects

Contract

	Designation	Funders
2016/05/01 - 2019/07/31	Papel dos astrócitos no controlo da memória- foco nos recetores adenosina A2A PTDC/NEU-NMC/4154/2014 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Conference poster

Madeira, Daniela; Dias, Liliana; Cunha, Rodrigo A; Canas, Paula M; Agostinho, Paula. "ATP release by astrocytes exposed to amyloid-ß peptides is modulated by a crosstalk between adenosine A2A receptors and connexin 43". Paper presented in International Conference on Alzheimer’s & Parkinson’s Diseases, 2022.
Madeira, Daniela; Dias, Liliana; Santos, Patrícia; Cunha, Rodrigo A; Canas, Paula M; Agostinho, Paula. "Association between adenosine A2A receptors and connexin 43 modulates hemichannels activity and ATP release in astrocytes exposed to amyloid-ß peptides". Paper presented in 11th FENS Forum of Neuroscience, 2022.
Madeira, Daniela; Dias, Liliana; Santos, Patrícia; Cunha, Rodrigo A; Canas, Paula M; Agostinho, Paula. "Association between adenosine A2A receptors and connexin 43 modulates hemichannels activity and ATP release in astrocytes exposed to peptides". Paper presented in VI symposium of the Portuguese Glia Network, 2022.
Lopes, Cátia; Madeira, Daniela; Domingues, Joana; Simões, Ana P; Canas, Paula M; Cunha, Rodrigo A; Agostinho, Paula. "The impact of silencing astrocytic A2A receptors on hippocampal synaptic plasticity and memory". Paper presented in 8th European Synapse Meeting, 2022.
Agostinho, Paula; Dias, Cândida; Carvalho, Rui A; Ledo, Ana; Laranjinha, João; Madeira, Daniela; Dias, Liliana; et al. "Astrocytic GPR55 receptors fuel glycolysis". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
Madeira, Daniela; Liliana, Dias; Santos, Patrícia; Cunha, Rodrigo A.; Canas, Paula M; Agostinho, Paula. "Association between adenosine A2A receptors and connexin 43 regulates hemichannels activity and ATP release in astrocytes exposed to amyloid-ß peptides". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
Agostinho, Paula; Dias, Cândida; Carvalho, Rui A ; Ledo, Ana; Laranjinha, João; Madeira, Daniela; Dias, Liliana; et al. "Astrocytic GPR55 receptors fuel glycolysis". Paper presented in Satellite of the XVII Meeting of the Portuguese Society for Neuroscience, 2021.
Dias, Liliana; Madeira, Daniela; Tomé, Angelo R.; Cunha, Rodrigo A.; Agostinho, Paula. "Crosstalk between ATP-P2Y1 and adenosine A2A receptors in the modulation of Ca2+ dynamics in Alzheimer's disease conditions". Paper presented in V Symposium Portuguese Glial Network – Satellite of the XVII Meeting of the Portuguese Society for Neuroscience, 2021.
Madeira, Daniela; Lopes, Cátia R.; Simões, Ana P; Canas, Paula M; Cunha, Rodrigo A.; Agostinho, Paula. "Effect of astrocytic A2A receptors on hippocampal synaptic plasticity and memory". Paper presented in V Symposium Portuguese Glial Network – Satellite of the XVII Meeting of the Portuguese Society for Neuroscience, 2021.
Dias, Liliana; Madeira, Daniela; Tomé, Ângelo; Canas, Paula; Cunha, Rodrigo; Agostinho, Paula. "Astrocytic Ca2+ dynamics and gliotransmitter release in Alzheimer's disease conditions". Paper presented in 8th Workshop on Calcium Signaling in Aging and Neurodegenerative Diseases of European Calcium Society, 2019.
Madeira, Daniela; Dias, Liliana; Tomé, Ângelo; Canas, Paula; Cunha, Rodrigo; Agostinho, Paula. "Adenosine A2A receptors control amyloid-ß peptides-induced alteration of Ca2+ dynamics and ATP release in astrocytes". Paper presented in XIV European Meeting on Glial Cells in Health and Diseases, 2019.
Madeira, Daniela; Dias, Liliana; Tomé, Ângelo; Canas, Paula; Cunha, Rodrigo; Agostinho, Paula. "Alterations in connexin 43 triggered by amyloid-ß in astrocytes: modulation by adenosine A2A receptors". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
Dias, Liliana; Madeira, Daniela; Canas, Paula; Tomé, Ângelo; Cunha, Rodrigo; Agostinho, Paula. "Amyloid-ß peptides affect astrocytic Ca2+ dynamics and exocytotic gliotransmitter release". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
Madeira, Daniela; Dias, Liliana; Tomé, Ângelo; Canas, Paula; Cunha, Rodrigo; Agostinho, Paula. "Amyloid-ß peptides affect astrocytic gliotransmitter release and Ca2+ dynamics. Protection by adenosine A2A receptors blockade". Paper presented in 14th International Conference on Alzheimer’s & Parkinson’s Diseases, 2019.
Madeira, Daniela; Dias, Liliana; Tomé, Ângelo; Canas, Paula; Cunha, Rodrigo; Agostinho, Paula. "Impact of amyloid-ß peptides on astrocytic gliotransmitter release and Ca2+ dynamics. Modulation by adenosine A2A receptors". Paper presented in 11th FENS Forum of Neuroscience, 2018.
10.5220/0001062300520057
Santos, Patrícia; Madeira, Daniela; Cunha, Rodrigo; Canas, Paula. "The role of astrocytic adenosine A2A receptors in depressive-like conditions". Paper presented in 11th FENS Forum of Neuroscience, 2018.
Dias, Liliana; Madeira, Daniela; Santos, Patrícia; Canas, Paula; Cunha, Rodrigo; Agostinho, Paula. "Alterations in astrocytic gliotransmitter release triggered by amyloid-ß peptides - modulation by adenosine A2A receptors". Paper presented in III Symposium of the Portuguese Glial Network, 2018.
Madeira, Daniela; Santos, Patrícia; Canas, Paula; Cunha, Rodrigo; Agostinho, Paula. "ATP and glutamate release by astrocytes under Alzheimer´s disease conditions: Modulation by adenosine A2A receptors". Paper presented in 31st Reunion of the group for the study of cerebral aging and dementia, 2017.
10.1109/sai.2015.7237286
Madeira, Daniela; Santos, Patrícia; Canas, Paula; Cunha, Rodrigo; Agostinho, Paula. "Astrocytic ATP (and glutamate) release under Alzheimer’s disease conditions.". Paper presented in XV Meeting of the Portuguese Society for Neuroscience, 2017.

Journal article

Madeira, Daniela; Joana Domingues; Cátia R. Lopes; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors". Cellular and Molecular Life Sciences (2023): https://doi.org/10.1007/s00018-023-04983-6.
10.1007/s00018-023-04983-6
Daniela Madeira; Cátia R. Lopes; Ana P. Simões; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice". Glia (2023): https://doi.org/10.1002/glia.24384.
10.1002/glia.24384
Cátia R. Lopes; Joana S Silva; Joana Santos; Matilde S Rodrigues; Madeira, Daniela; Andreia Oliveira; Ana Moreira-de-Sá; et al. "Downregulation of sirtuin 1 does not account for the impaired long-term potentiation in the prefrontal cortex of female APPswe/PS1dE9 mice modelling Alzheimer's disease". International journal of molecular sciences 24 8 (2023): 6968.
Published • 10.3390/ijms24086968
Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula Agostinho; Paula M. Canas. "Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes". Purinergic Signalling (2022): https://doi.org/10.1007/s11302-022-09864-4.
10.1007/s11302-022-09864-4
Lopes, Cátia R.; Amaral, Inês M; Pereira, Marlene F; Lopes, João P; Madeira, Daniela; Canas, Paula M; Cunha, Rodrigo A.; Agostinho, Paula. "Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure". Journal of Neurochemistry (2022):
Published
Liliana Dias; Madeira, Daniela; Rafael Dias; Ângelo R Tomé; Rodrigo A Cunha; Paula Agostinho. "Aß1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes". Cellular and molecular life sciences 79 8 (2022): 457.
Published • 10.1007/s00018-022-04492-y
Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula M. Canas; Paula Agostinho. "Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-ß Peptides". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-021-02538-z.
10.1007/s12035-021-02538-z
Pereira, Marlene F; Amaral, Inês M ; Lopes, Cátia R.; Leitão, Catarina; Madeira, Daniela; Lopes, João P; Gonçalves, Francisco Q; et al. "L-a- aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory". The FASEB Journal 35 8 (2021): e21726.
Published • 10.1096/fj.202100336R
Paula Agostinho; Daniela Madeira; Liliana Dias; Ana Patrícia Simões; Rodrigo A. Cunha; Paula M. Canas. "Purinergic signaling orchestrating neuron-glia communication". Pharmacological Research (2020): 105253-105253. https://doi.org/10.1016/j.phrs.2020.105253.
10.1016/j.phrs.2020.105253

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023	Adenosine A2A receptors modulate astrocytic hemichannels activity in the hippocampus in non-pathological and Alzheimer's disease-like conditions	Annual Reunion of the Portuguese Society of Pharmacology (Coimbra, Portugal)
2022/02/11	Astrocytes are active players in Alzheimer's Disease through the modulation of synaptic plasticity	Annual Reunion of the Portuguese Society of Pharmacology (Porto, Portugal)
2022/02/11	Astrocytic A2A receptors modulate hippocampal-dependent memory and synaptic plasticity	Annual Reunion of the Portuguese Society of Pharmacology (Porto, Portugal)
2022/02/11	Association between adenosine A2A receptors and connexin43 regulates hemichannels activity in astrocytes exposed to amyloid-ß peptides	Annual Reunion of the Portuguese Society of Pharmacology (Porto, Portugal)
2021/02/17	Adenosine A2A receptors modulate hemichannels activity in astrocytes treated with amyloid-ß peptides	Annual Reunion of the Portuguese Society of Pharmacology Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2021/02/17	Functional interaction between ATP-P2X7 and adenosine A2A receptors in the control of microglial Ca2+ levels	Annual Reunion of the Portuguese Society of Pharmacology Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2020/02	Effect of astrocytic A2A receptors on hippocampal synaptic plasticity and memory	L Annual Reunion of the Portuguese Society of Pharmacology Portuguese Society of Pharmacology (Coimbra, Portugal)
2020/02	Involvement of purinergic receptors in astrocytic Ca2+ dynamics in Alzheimer's disease conditions	L Annual Reunion of the Portuguese Society of Pharmacology Portuguese Society of Pharmacology (Coimbra, Portugal)
2020/02	Gliotoxin L-¿-Aminoadipate causes a biphasic effect on astrocytes with negative impact on synaptic plasticity in the mouse hippocampus	L Annual Reunion of the Portuguese Society of Pharmacology Portuguese Society of Pharmacology (Coimbra, Portugal)
2019/02	Impact of amyloid-ß peptides on astrocytic gliotransmitters release: modulation by adenosine A2A receptors	XLIX Annual Reunion Portuguese Society of Pharmacology (Porto, Portugal)
2019/02	Involvement of adenosine A2A receptors in astrocytic Ca2+ dynamics in Alzheimer’s disease-like conditions	XLIX Annual Reunion of the Portuguese Society of Pharmacology Portuguese Society of Pharmacology (Porto, Portugal)
2018/02	ATP and glutamate release by astrocytes under Alzheimer´s disease conditions: Modulation by adenosine A2A receptors	XLVIII Annual Reunion of the Portuguese Society of Pharmacology Portuguese Society of Pharmacology (Lisbon, Portugal)