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Liliana Dias holds a Master's degree in Biochemistry (2018) and a Bachelor's degree in Biology (2016) from the Faculty of Sciences and Technology, University of Coimbra. Currently pursuing a PhD in Health Sciences at the Faculty of Medicine, University of Coimbra, supported by an FCT PhD fellowship, focusing on the impact of stress conditions on aquaporin-4 and its modulation by adenosine A2A receptors. Her previous experience includes research on calcium dynamics and purinergic receptors in Alzheimer’s disease conditions, developed during her master’s thesis and further expanded through a research fellowship. These experiences contributed to the development of diverse skills in advanced cellular and molecular techniques. Published 8 peer-reviewed articles in journals such as Journal of Neurochemistry and International Journal of Molecular Sciences. Recipient of multiple distinctions, including travel grants for international conferences and participation in advanced training programs. Actively participated in numerous national and international scientific conferences, presenting her research findings. She has also been involved in outreach activities, such as neuroscience workshops for primary schools during Brain Awareness Week. Experienced in supervising undergraduate and master’s students, with a strong commitment to combining academic rigor with translational impact. Her research interests include astrocytes, neuropsychiatric and neurodegenrative disorders, including maladaptive stress, depression and Alzheimer's disease; glymphatic system, aquaporin-4, astrocytic calcium dynamics and adenosine A2A receptors.
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Identification

Personal identification

Full name
Liliana Rodrigues Dias

Citation names

  • Dias, Liliana

Author identifiers

Ciência ID
6418-41B9-C723
ORCID iD
0000-0001-7032-5212

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1) Upper intermediate (B2)
Spanish; Castilian Intermediate (B1) Advanced (C1) Intermediate (B1) Upper intermediate (B2) Intermediate (B1)
Education
Degree Classification
2023/07/01 - 2023/07/29
Concluded
 Health Innovation Entrepreneurship Program - Top Female Founders Summer School 2023, promoted by EIT Health and Boehringer Ingelheim (Outros)
Major in Health Innovation Entrepreneurship
Boehringer Ingelheim Pharmaceutical Research and Development Centre Vienna, Austria

EIT Health, Germany
Approved
2020/09 - 2023
Ongoing
 Doctoral Programme in Health Sciences (Doutoramento)
Major in Biomedicine
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/11 - 2020/11/20
Concluded
 IV Modular Training in Laboratory Animal Science (Outros)
Universidade de Coimbra, Portugal
 Approved
2016/08/11 - 2018/09/10
Concluded
 Biochemistry (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Effect of amyloid-beta peptides on astrocytic Ca2+ signaling and gliotransmission: modulation by adenosine A2A receptors" (THESIS/DISSERTATION)
 18
2013/09/11 - 2016/07/12
Concluded
 Biology (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2020/03/01 - Current Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/11/22 - 2020/02/29 Researcher (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/09/01 - 2018/09/13 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Grant

Designation Funders
2020/03/01 - Current Role of astrocytic adenosine A2A receptors in controlling aquaporin 4 under conditions of chronic stress
SFRH/BD/147159/2019
PhD Student Fellow
Fundação para a Ciência e a Tecnologia

Other

Designation Funders
2017/09/01 - 2019/07/31 Role of astrocytes on the control of memory - focus on adenosine A2A receptors
PTDC/NEU-NMC/4154/2014
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Dias, Liliana; Ana Margarida Nabais; Ferreira, Samira G.; Joana Silva; Canas, Paula M.; Cunha, Rodrigo A.; Agostinho, Paula. "Astrocytic aquaporin-4 alterations under stress conditions: modulation by adenosine A2A receptors". Paper presented in VII Symposium of the Portuguese GlialNetwork, 2024.
  2. Dias, Liliana; Nabais, Margarida; Ferreira, Samira G.; Silva, Joana; Canas, Paula M.; Cunha, Rodrigo A.; Agostinho, Paula. "Stress conditions affect astrocytic aquaporin-4: modulation by adenosine A2A receptors". Paper presented in 11th IBRO World Congress, 2023.
  3. Dias, Liliana; Nabais, Margarida; Ferreira, Samira G.; Silva, Joana; Canas, Paula M.; Cunha, Rodrigo A.; Agostinho, Paula. "Adenosine A2A receptors control the alterations of astrocytic aquaporin-4 under stress conditions". Paper presented in ISN-ESN Meeting, 2023.
  4. Dias, Liliana; Dias, Rafael; Tomé, Angelo R.; Cunha, Rodrigo A.; Agostinho, Paula. "Microglial Ca2+ levels: crosstalk between ATP-P2X7 and adenosine A2A receptors". Paper presented in VI Symposium of the Portuguese Glial Network, 2022.
  5. Nabais, Margarida; Dias, Liliana; Cunha, Rodrigo A.; Agostinho, Paula. "Astrocytes role in protein clearance under stress-like conditions: modulation by adenosine A2A receptors". Paper presented in VI Symposium of the Portuguese Glial Network, 2022.
  6. Dias, Liliana; Madeira, Daniela; Tomé, Angelo R.; Cunha, Rodrigo A.; Agostinho, Paula. "Involvement of purinergic receptors in astrocytic Ca2+ dynamics in Alzheimer's disease conditions". Paper presented in International Conference on Alzheimer's and Parkinson's Diseases, 2022.
  7. Agostinho, Paula; Dias, Cândida; Carvalho, Rui A.; Ledo, Ana; Laranjinha, João; Madeira, Daniela; Dias, Liliana; et al. "Astrocytic GPR55 Receptors Fuel Glycolysis". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  8. Dias, Liliana; Dias, Rafael; Tomé, Angelo R.; Cunha, Rodrigo A.; Agostinho, Paula. "Crosstalk between ATP-P2X7 and adenosine A2A receptors in the control of microglial Ca2+ levels". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  9. Dias, Liliana; Madeira, Daniela; Tomé, Angelo R.; Cunha, Rodrigo A.; Agostinho, Paula. "Crosstalk between ATP-P2Y1 and adenosine A2A receptors in the modulation of astrocytic Ca2+ dynamics in Alzheimer's disease conditions". Paper presented in V Symposium of the Portuguese Glial Network, 2021.
  10. Agostinho, Paula; Dias, Cândida; Carvalho, Rui A.; Ledo, Ana; Laranjinha, João; Madeira, Daniela; Dias, Liliana; et al. "Astrocytic GPR55 receptors fuel glycolysis". Paper presented in V Symposium of the Portuguese Glial Network, 2021.
  11. Dias, Liliana; Madeira, Daniela; Tomé, Ângelo R.; Canas, Paula; Cunha, Rodrigo A.; Agostinho, Paula. "Astrocytic Ca2+ dynamics and gliotransmitter release in Alzheimer's disease conditions". Paper presented in CIBB Meeting, 2019.
  12. Dias, Liliana; Madeira, Daniela; Tomé, Ângelo R.; Canas, Paula M.; Cunha, Rodrigo A.; Agostinho, Paula. "Astrocytic Ca2+ dynamics and gliotransmitter release in Alzheimer's disease conditions". Paper presented in 8th Workshop on Calcium Signaling in Aging and Neurodegenerative Diseases of European Calcium Society, 2019.
  13. Madeira, Daniela; Dias, Liliana; Tomé, Ângelo R.; Canas, Paula M; Cunha, Rodrigo A.; Agostinho, Paula. "Adenosine A2A receptors control amyloid-ß peptides-induced alteration of Ca2+ dynamics and ATP release in astrocytes". Paper presented in XVI European Meeting on Glial Cells in Health and Disease, 2019.
  14. Dias, Liliana; Madeira, Daniela; Canas, Paula M.; Tomé, Ângelo R.; Cunha, Rodrigo A.; Agostinho, Paula. "Amyloid-ß peptides affect astrocytic Ca2+ dynamics and exocytotic gliotransmitter release". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  15. Madeira, Daniela; Dias, Liliana; Canas, Paula M.; Cunha, Rodrigo A.; Agostinho, Paula. "Alterations in connexin 43 triggered by amyloid-ß in astrocytes: modulation by adenosine A2A receptors". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  16. Madeira, Daniela; Dias, Liliana; Tomé, Ângelo R.; Santos, Patrícia; Canas, Paula M.; Rodrigo, Cunha A.; Agostinho, Paula. "Amyloid-ß peptides affect astrocytic gliotransmitter release and Ca2+ dynamics. Protection by adenosine A2A receptors blockade". Paper presented in 14th International Conference on Alzheimer's and Parkinson's Diseases, 2019.
  17. Madeira, Daniela; Dias, Liliana; Tomé, Ângelo R.; Canas, Paula M.; Cunha, Rodrigo A.; Agostinho, Paula. "Impact of amyloid-ß peptides on astrocytic gliotransmitter release and Ca2+ dynamics - modulation by adenosine A2A receptors". Paper presented in 11th FENS Forum of Neuroscience in Berlin, 2018.
  18. Dias, Liliana; Madeira, Daniela; Santos, Patrícia; Canas, Paula M.; Cunha, Rodrigo A.; Agostinho, Paula. "Alterations in astrocytic gliotransmitter release triggered by amyloid-ß peptides - modulation by adenosine A2A receptors". Paper presented in III Symposium of Portuguese Glial Network, 2018.
Journal article
  1. Liliana Dias; Ana Margarida Nabais; Vladimir P. P. Borges-Martins; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Impact of Glucocorticoid-Associated Stress-Like Conditions on Aquaporin-4 in Cultured Astrocytes and Its Modulation by Adenosine A2A Receptors". Journal of Neurochemistry (2025): https://doi.org/10.1111/jnc.16299.
    10.1111/jnc.16299
  2. Xiaoting Sun; Liliana Dias; Chenlei Peng; Ziyi Zhang; Haoting Ge; Zejun Wang; Jiayi Jin; et al. "40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice". Cell Discovery (2024): https://doi.org/10.1038/s41421-024-00701-z.
    10.1038/s41421-024-00701-z
  3. Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.; Gonçalves, Francisco Q.; Rial, Daniel; et al. "Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress". ACS Chemical Neuroscience 14 7 (2023): 1299-1309. http://dx.doi.org/10.1021/acschemneuro.2c00810.
    Published • 10.1021/acschemneuro.2c00810
  4. Liliana Dias; Daniela Madeira; Rafael Dias; Ângelo R. Tomé; Rodrigo A. Cunha; Paula Agostinho. "Aß1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes". Cellular and Molecular Life Sciences (2022): https://doi.org/10.1007/s00018-022-04492-y.
    10.1007/s00018-022-04492-y
  5. Madeira, Daniela; Dias, Liliana; Santos, Patrícia; Cunha, Rodrigo A.; Agostinho, Paula; Canas, Paula M.. "Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes". Purinergic Signalling (2022):
    Accepted
  6. Madeira, Daniela; Dias, Liliana; Santos, Patrícia; Cunha, Rodrigo A.; Canas, Paula M.; Agostinho, Paula. "Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-ß Peptides". Molecular Neurobiology 58 12 (2021): 6232-6248. http://dx.doi.org/10.1007/s12035-021-02538-z.
    Published • 10.1007/s12035-021-02538-z
  7. Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana; Pochmann, Daniela; Machado, Nuno J.; Tomé, Angelo R.; Agostinho, Paula; Cunha, Rodrigo A.. "Crosstalk between ATP-P2X7 and adenosine A2A receptors controlling neuroinflammation and in rats subject to repeated restraint stress". Frontiers in Cellular Neuroscience 15 639322 (2021): https://www.frontiersin.org/articles/10.3389/fncel.2021.639322/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Cellular_Neuroscience&id=639322.
    Open access • Published • 10.3389/fncel.2021.639322
  8. Paula Agostinho; Daniela Madeira; Liliana Dias; Ana Patrícia Simões; Rodrigo A. Cunha; Paula M. Canas. "Purinergic signaling orchestrating neuron-glia communication". Pharmacological Research (2020): 105253-105253. https://doi.org/10.1016/j.phrs.2020.105253.
    10.1016/j.phrs.2020.105253
Thesis / Dissertation
  1. "Effect of Amyloid-beta Peptides on Astrocytic Ca2+ Signalling and Gliotransmission: Modulation by Adenosine A2A Receptors". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2018. https://hdl.handle.net/10316/86153.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/05/27 Stress conditions affect astrocytic aquaporin-4: modulation by adenosine A2A receptors 10th IMFAHE International Conference
2023/12/20 Impact of stress-like conditions in astrocytes: modulation by adenosine A2A receptors CIBB meeting 2023
(Coimbra, Portugal)
2023/02/03 Stress conditions affect the activity of the glymphatic system: involvement of adenosine A2A receptors LII Reunião Anual da Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)
2023/02/02 Impact of restrain stress on the density of aquaporin 4 and Kir4.1: putative modulation by adenosine A2A receptors LII Reunião Anual da Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)
2022/02/11 Association between adenosine A2A receptors and connexin43 regulates hemichannels activity in astrocytes exposed to amyloid-ß peptides LII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2022/02/10 Involvement of adenosine A2A receptors in glymphatic system activity in stress-like conditions LII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2021/02/17 Functional Interaction between ATP-P2X7 and adenosine A2A receptors in the control of microglial Ca2+ levels 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2021/02/17 Adenosine A2A receptors modulate hemichannels activity in astrocytes treated with amyloid-B peptides 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2020/02/06 Involvement of purinergic receptors in astrocytic Ca2+ dynamics in Alzheimer's disease conditions
L Reunião Anual da Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/02/07 Involvement of adenosine A2A receptors in astrocytic Ca2+ dynamics in Alzheimer’s disease-like conditions XLIV Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/02/07 Impact of amyloid-ß peptides on astrocytic gliotransmitters release: modulation by adenosine A2A receptors XLIV Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2018/02/05 ATP and glutamate release by astrocytes under Alzheimer´s disease conditions: modulation by adenosine A2A receptors XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/03 - Current Neuroscience outreach activities conducted in primary schools as part of Brain Awareness Week
Other
 Brain Awareness Week 2024

Mentoring / Tutoring

Topic Student name
2023/02 - Current Experimental project tutor in the advanced course “Pathogenic Mechanisms in Neuropsychiatric and Neurodegenerative Disorders” of the Doctoral Program in Experimental Biology and Biomedicine 1 PhD student
2019 - 2023 Bench-supervisor of 3 master's students within the scope of their thesis 3 Master's students
2019 - 2023 Bench-supervisor of 5 bachelor's students within the scope of their project internship 5 Bachelor's students
Distinctions

Award

2023 Travel Grant - International Society for Neurocheistry/European Society for Neurochemistry
International Society for Neurochemistry, Switzerland
2023 IBRO World Congress Travel Grant
International Brain Research Organization, France

Other distinction

2023 Early Career Training Program - Selected by IBRO for a short-stay in the laboratory of Prof. Marta Navarrete, with the project “Characterization of the physiological consequences of astrocyte-to-neuron emsembles on local neuron excitability"
International Brain Research Organization, France
2023 Selected student in Top Female Founders School 2023 – Health Innovation Entrepreneurship Program, promoted by EIT Health and Boehringer Ingelheim
Boehringer Ingelheim Pharmaceutical Research and Development Centre Vienna, Austria

EIT Health, Germany
2023 Selected mentee for the International Mentoring Program of IMFAHE's Platform of Talent 2023-2024
2019 Awarded a PhD fellowship by the Fundação para a Ciência e a Tecnologia (FCT)
Fundação para a Ciência e a Tecnologia, Portugal