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Joana São José Dias Amaral concluiu o Doutoramento em Farmácia, em 2008, pela Universidade de Lisboa. Licenciou-se em Biologia (ramo científico), em 2002, pela Faculdade de Ciências da Universidade de Lisboa. Leciona as aulas laboratoriais de Bioquímica II do Mestrado Integrado em Ciências Farmacêuticas, bem como as unidades curriculares de Sinalização Celular e Oncobiologia do Mestrado em Ciências Biofarmacêuticas da Faculdade de Farmácia da ULisboa. Publicou 33 artigos em revistas especializadas. Possui 3 capítulos de livros. Recebeu 4 prémios e/ou homenagens. Atua na área de Ciências Médicas e da Saúde com ênfase em Medicina Básica. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica são: neuroinflamação; necroptose; apoptose; metabolismo; sinalização celular; p53; fígado; tumorigénese; spirooxindóis; interação p53-Mdm2; células estaminais; neuroregeneração; pequenas moléculas; doença de Parkinson; neurodegenerescência; drug discovery; microRNAs.
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Identification

Personal identification

Full name
Joana São José Dias Amaral

Citation names

  • Amaral, Joana
  • Amaral, JD

Author identifiers

Ciência ID
641A-6130-88ED
ORCID iD
0000-0001-9504-5102
Researcher Id
M-4660-2013
Scopus Author Id
8912000100

Knowledge fields

  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2015
Concluded
 Comunicação de Ciência (Pós-Graduação)
Universidade Nova de Lisboa Faculdade de Ciências Sociais e Humanas, Portugal
"n/a" (THESIS/DISSERTATION)
 16/20
2008
Concluded
 Doutoramento em Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"p53, a novel molecular target of ursodeoxycholic acid in modulating hepatocyte apoptosis" (THESIS/DISSERTATION)
 Aprovado com Distinção e Louvor
2002
Concluded
 Biologia (ramo científico) (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Construção de recombinantes NAT2 e expressão heteróloga em células de mamífero - Definição de um modelo para o estudo de factores genéticos e ambientais de susceptibilidade a doenças neurodegenerativas" (THESIS/DISSERTATION)
 16/20
Affiliation

Science

Category
Host institution 		Employer
2019/02 - 2020/12/31 Contracted Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/02/01 - 2019/02/10 Postdoc (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2009/01/01 - 2014/12/31 Postdoc (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021/01/01 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2019 Invited Assistant Professor (University Teacher) Universidade de Lisboa, Portugal
2011/12/23 - 2018/12/22 Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/10/01 - 2017/12/31 Visiting Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2016 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2016/07/01 - 2016/07/31 Professional training in Pre-Award Grant Management, under the supervision of Dr. Beatriz García Fernandez, Coordinator of Centro de Investigação, ISPA – Instituto Universitário de Ciências Psicológic Instituto Universitário de Ciências Psicológicas Sociais e da Vida, Portugal
2014/09/15 - 2015/06/30 Post-graduation course on Science Communication Universidade Nova de Lisboa Faculdade de Ciências Sociais e Humanas, Portugal
2008/10/01 - 2008/12/31 Research Fellowship (BI) Universidade de Lisboa Faculdade de Farmácia, Portugal
2004/09/01 - 2008/08/31 PhD Fellowship Universidade de Lisboa Faculdade de Farmácia, Portugal
2002/11/01 - 2004/09/30 Research Fellowship (BIC) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2001/10/01 - 2002/10/01 Professional Training Universidade de Lisboa Faculdade de Farmácia, Portugal
Outputs

Publications

Book chapter
  1. Dionísio, Pedro A.; Amaral, Joana D.; Rodrigues, Cecília M.P.. "Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases". In International Review of Cell and Molecular Biology. Elsevier, 2020.
    10.1016/bs.ircmb.2019.12.006
  2. Amaral, JD; Rodrigues, CMP. "Inter-relações metabólicas e patologias – Apoptose.". In Bioquímica - Fundamentos e Correlações Clínicas.. Lisboa, Portugal: Lidel, 2018.
    In press
  3. Amaral, Joana; Solá, Susana; Steer, Clifford; Rodrigues, Cecília. "Nuclear Steroid Receptors in Apoptosis". In Modern Insights Into Disease From Molecules to Man; Apoptosis, 115-131. Londres, United Kingdom: Science Publishers, 2010.
    Published • 10.1201/9781439845431-10
Conference abstract
  1. Amaral, JD; Dionísio, PA; Oliveira, SR; Rodrigues, CMP. "Genetic ablation of RIP3 protects from dopaminergic neuronal death in the MPTP-mouse model of Parkinson’s disease.". Paper presented in Euroconference on Apoptosis, St. Petersburg, 2019.
    Published
  2. Amaral JD, Dionísio PE, Oliveira SR, Rodrigues CMP.. "Genetic ablation of RIP3 protects from dopaminergic neuronal death in the MPTP-mouse model of Parkinson’s disease.". Paper presented in 26th Conference of European Cell Death Organization, St. Petersburg, 2018.
    Published
  3. Dionísio, PA; Amaral, JD; Ribeiro, MF; Lo, AC; D'Hooge, R; Rodrigues, CMP. "TUDCA Treatment Ameliorates Inflammation in Alzheimer’s Disease (AD) Models.". Paper presented in International Conference on Alzheimer's & Parkinson's Diseases, NIce, 2015.
    Published
  4. Ribeiro, MF; Dionísio, PA; Lo, AC; D'Hooge, R; Amaral, JD; Rodrigues, CMP. "TUDCA attenuates A-beta load in APP/PS1 mice before and after the onset of amyloid pathology by modulating abeta clearance.". Paper presented in International Conference on Alzheimer's & Parkinson's diseases., Nice, 2015.
    Published
  5. Afonso, MB; Rodrigues, PM; Simão, AL; Cortez-Pinto, H; Ofengeim, D; Amaral, JD; Castro, RE; Yuan, J; Rodrigues, CMP. "Necroptosis contributes to the pathogenesis of cholestatic liver injury.". Paper presented in The International Liver Conference, Vienna, 2015.
    Published
  6. Afonso MB, Rodrigues PM, Simão AL, Cortez-Pinto H, Ofengeim D, Amaral JD, Castro RE, Yuan J, Rodrigues CMP.. "Papel da necroptose na colestase em ratinhos e doentes.". Paper presented in Semana Digestiva - Sociedade Portuguesa de Gastrenterologia, Porto, 2015.
    Published
  7. Amaral, JD; Borralho, PM; Nunes, AF; Zeng, Y; Sarver, AL; Steer, CJ; Rodrigues, CMP. "Understanding brain microRNA profiling in the double transgenic APP/PS1 mouse model of Alzheimer’s disease.". Paper presented in Alzheimer's Association International Conference, Vancouver, 2012.
    Published
  8. Amaral, JD; Castro, RE; Solá, S; Rodrigues, CMP. "Modulation of the p53 ubiquitin-proteasome degradation pathway by ursodeoxycholic acid.". Paper presented in The International Liver Conference, Copenhagen, 2009.
    Published
  9. Amaral JD, Castro RE, Solá S, Rodrigues CMP.. "Modulation of the p53 ubiquitin-proteasome degradation pathway by ursodeoxycholic acid.". Paper presented in 44th Annual Meeting of the European Association for the Study of the Liver, Copenhagen, 2009.
    Published
  10. Amaral, JD; Castro, RE; Solá, S; Rodrigues, CMP. "Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53.". Paper presented in The International Liver Conference, Milan, 2008.
    Published
  11. Amaral, JD; Castro, RE; Solá, S; Rodrigues, CMP. "Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53.". Paper presented in Annual Meeting of the American Association for the Study of Liver Diseases, San Francisco, 2008.
    Published
  12. Amaral, JD; Castro RE, Solá S, Rodrigues CMP.. "O ácido ursodesoxicólico modula a degradação da proteína p53 pelo proteossoma.". Paper presented in Semana Digestiva - Sociedade Portuguesa de Gastrenterologia, 2008.
    Published
  13. Amaral, JD; Castro, RE; Solá, S; Rodrigues, CMP. "p53 is a specific molecular target of ursodeoxycholic acid.". Paper presented in The International Liver Conference, Barcelona, 2007.
    Published • 10.1158/1538-7445.am10-595
  14. Castro, RE; Amaral, JD; Solá, S; Kren, BT; Steer, CJ; Rodrigues, CMP. "Differential regulation of cyclin D1 and apoptosis by bile acids in primary rat hepatocyte.". Paper presented in The International Liver Conference, Barcelona, 2007.
  15. Amaral, JD; Castro, RE; Solá, S; Steer, CJ; Rodrigues, CMP. "p53 is a specific molecular target of ursodeoxycholic acid in regulating apoptosis.". Paper presented in Annual Meeting of the American Association for the Study of Liver Diseases, Boston, 2007.
    Published
  16. Amaral, JD; Castro RE, Solá S, Rodrigues CMP.. "A proteína p53 é um alvo molecular chave na regulação da apoptose mediada pelo ácido ursodesoxicólico.". Paper presented in Semana Digestiva - Sociedade Portuguesa de Gastrenterologia, 2007.
    Published
  17. Amaral, JD; Castro, RE; Solá, S; Rodrigues, CMP. "Modulation of pro-apoptotic p53 transcriptional targeting by bile acids in primary rat hepatocytes.". Paper presented in The International Liver Conference, Vienna, 2006.
    Published
  18. Castro, RE; Amaral, JD; Borralho, PM; Solá, S; Kren, BT; Steer, CJ; Rodrigues, CMP. "Bile acids differentially regulate cell cycle and apoptosis-related proteins in primary rat hepatocytes.". Paper presented in The International Liver Conference, Vienna, 2006.
    Published
  19. Castro, RE; Amaral, JD; Kren, BT; Steer, CJ; Rodrigues, CMP. "Ursodeoxycholic acid modulates cell cycle proteins that control apoptosis of primary rat hepatocytes.". Paper presented in The International Liver Conference, Paris, 2005.
    Published
  20. Solá, S; Amaral, JD; Castro, RE; Ramalho, RM; Kren, BT; Steer, CJ; Rodrigues, CMP. "Nuclear steroid receptors modulate cellular trafficking of ursodeoxycholic acid in primary rat hepatocytes.". Paper presented in The International Liver Conference, Paris, 2005.
    Published
  21. Ramalho, RM; Borralho, PM; Solá, S; Castro, RE; Amaral, JD; Rodrigues, CMP. "Modulation of neurotoxicity associated with Alzheimer’s disease-linked amyloid precursor protein mutations by tauroursodeoxycholic acid.". Paper presented in The FEBS Congress, Budapest, 2005.
    Published
  22. Solá, S; Amaral, JD; Castro, RE; Ramalho, RM; Borralho, PM; Kren, BT; Steer, CJ; Rodrigues, CMP. "Nuclear translocation of UDCA via the glucocorticoid receptor is essential for inhibiting TGF-ß1-induced apoptosis of rat hepatocytes.". Paper presented in Annual Meeting of the American Association for the Study of Liver Diseases, San Francisco, 2005.
    Published
  23. Solá S, Amaral JD, Castro RE, Ramalho RM, Kren BT, Steer CJ, Rodrigues CMP.. "Receptores nucleares de esteróides modulam o tráfego celular do ácido ursodesoxicólico em hepatocitos de rato.". Paper presented in Semana Digestiva - Sociedade Portuguesa de Gastrenterologia, 2005.
    Published
Conference paper
  1. Elizabeth A. Lopes; Margarida Espadinha; Joana D. Amaral; Rebecca Piccarducci; Elisa Zappelli; Simona Daniele; Claudia Martini; et al. "Designing novel spiropyrazoline oxindoles to dual target p53-MDM2/X PPIs". 2023.
    10.14232/syrmpnpr.2023.12
Conference poster
  1. Dionísio PA, Oliveira SR, Amaral JD, Rodrigues CMP.. "Genetic deletion of RIP3 abrogates dopaminergic neuronal death in the MPTP-mouse model of Parkinson’s disease.". Paper presented in The 14th International Conference on Alzheimer’s & Parkinson’s diseases., 2019.
  2. Oliveira SR, Dionísio PA, Correia-Guedes L, Ferreira JJ, Amaral JD, Rodrigues CMP.. "Circulating miRNAs in discovery and validation cohorts of patients with Parkinson’s disease.". Paper presented in The 14th International Conference on Alzheimer’s & Parkinson’s diseases., 2019.
  3. Pinho JO, Ferreira M, Mendes E, Rocha MJ , Amaral JD, Rodrigues CMP, Francisco AP, Gaspar MM.. "New hybrid molecule with high potential against melanoma: in vitro and in vivo evaluation.". Paper presented in XIV Congreso de la Sociedad Española de Farmacia Industrial y Galénica (SEFIG), 2019.
  4. Oliveira SR, Dionísio PA, Correia-Guedes L, Ferreira JJ, Amaral JD, Rodrigues CMP.. "Circulating miRNAs in discovery and validation cohorts of patients with Parkinson’s disease.". Paper presented in 4th Meeting from the Mind-Brain College of the Universidade de Lisboa, 2019.
  5. Amaral JD, Dionísio PA, Oliveira SR, Rodrigues CMP. "Parkin influences necroptosis and inflammation in microglia.". Paper presented in Workshop on Integrative Approaches in Neurodegeneration, 2018.
  6. Dionísio PA, Oliveira SR, Amaral JD, Rodrigues CMP. "Parkin influences necroptosis and inflammation in microglia.". Paper presented in 11th FENS Forum of Neuroscience, 2018.
  7. Oliveira SR, Dionísio PA, Brito H, Rodrigues CAB, Guedes RC, Afonso CAM, Amaral JD, Rodrigues CMP. "Phenotypic screening identifies a new inhibitor of necroptosis and neuroinflammation.". Paper presented in 11th FENS Forum of Neuroscience, 2018.
  8. Oliveira SR, Dionísio PA, Brito H, Rodrigues CAB, Guedes RC, Afonso CAM, Amaral JD, Rodrigues CMP.. "Phenotypic screening identifies a new inhibitor of necroptosis and neuroinflammation.". Paper presented in 10th iMed.ULisboa Postgraduate Students Meeting and 2nd i3DU Meeting, 2018.
  9. Dionísio PA, Oliveira SR, Amaral JD, Rodrigues CMP.. "Microglial Parkin at the crossroads between neuroinflammation and necroptosis.". Paper presented in XV Meeting of the Portuguese Society for Neurosciences, 2017.
  10. Amaral JD, Oliveira SR, Dionísio PA, Rodrigues CAB, Afonso CAM, Rodrigues CMP. "Screening for potential modulators of necroptosis in a microglial cell line.". Paper presented in 10th FENS Forum of Neuroscience, 2016.
  11. Dionísio PA, Ribeiro MFC, Lo AC, D’Hooge RC, Rodrigues CMP; Amaral, JD. "TUDCA attenuates amyloid-ß pathology and glial activation in in vivo and in vitro models of Alzheimer’s disease.". Paper presented in EMBO Workshop - Macromolecular assemblies at the crossroads of cell stress and function, 2015.
  12. Afonso MB, Rodrigues PM, Simão AL, Cortez-Pinto H, Ofengeim D,; Amaral, JD; Castro RE, Yuan J, Rodrigues CMP.. "Pathogenic role of necroptosis in cholestatic liver disease.". Paper presented in AASLD and Industry Colloquium: Novel Targets and Therapies in Liver Disease, 2015.
  13. Dionísio PA,; Amaral, JD; Ribeiro MFC, Lo AC, D’Hooge R, Rodrigues CMP. "Tauroursodeoxycholic acid ameliorates neuroinflammation in in vivo and in vitro models of Alzheimer’s Disease.". Paper presented in EMBO|EMBL Symposium – Mechanisms of Neurodegeneration, 2015.
  14. Ribeiro MFC, Dionísio PA, Lo AC, D’Hooge R,; Amaral, JD; Rodrigues CMP.. "TUDCA attenuates amyloid-beta peptide load in APP/PS1 mice before and after the onset of amyloid pathology.". Paper presented in EMBO|EMBL Symposium – Mechanisms of Neurodegeneration, 2015.
  15. Amaral, JD; Dionísio PA, Ribeiro MF, Lo AC, D’Hooge R, Rodrigues CMP.. "TUDCA attenuates neuroinflammation and amyloid precursor protein processing in APP/PS1 mice after the onset of amyloid pathology.". Paper presented in 9th FENS Forum of Neuroscience., 2014.
  16. Afonso MB, Caridade M, Rodrigues PM, Cortez-Pinto H,; Amaral, JD; Castro RE, Rodrigues CMP. "Regulated necrosis in bile acid-induced toxicity.". Paper presented in XXIII International Bile Acid Meeting, 2014.
  17. Ribeiro, CJA; Amaral, JD; Rodrigues CMP, Moreira R, Santos MMM.. "Spiroisoxazoline Oxindoles: New p53-MDM2 Interaction Inhibitors.". Paper presented in Frontiers in Medicinal Chemistry, 2013.
  18. Ribeiro CJA,; Amaral, JD; Rodrigues CMP, Moreira R, Santos MMM.. "Spiroisoxazoline Oxindoles: Novel Small-Molecule Inhibitors of the p53-MDM2 Interaction.". Paper presented in 2nd Working Group Meeting of COST Action CMI 106: Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells, 2013.
  19. Dionísio PA, Amaral JD, Lo AC, D’Hooge R, Rodrigues CMP.. "TUDCA reduces amyloid precursor protein processing in APP/PS1 mice after the onset of amyloid pathology.". Paper presented in EMBO Young Scientists' Forum, 2013.
  20. Amaral, JD; Borralho PM, Nunes AF, Zeng Y, Sarver AL, Steer CJ, Rodrigues CMP.. "Bile acid modulation of brain microRNAs in the double transgenic APP/PS1 mouse model of Alzheimer’s disease.". Paper presented in XXII International Bile Acid Meeting, 2012.
  21. Ribeiro CJA, Amaral JD, Rodrigues CMP, Moreira R, Santos MMM.. "Synthesis and biological evaluation of new spiroisoxazoline oxindoles as potential anticancer agents.". Paper presented in European Federation for Medicinal Chemistry - 22nd International Symposium on Medicinal Chemistry (EFMC-ISMC), 2012.
  22. Amaral, JD; Castro RE, Solá S, Steer CJ, Rodrigues CMP.. "Ursodeoxycholic acid specifically targets p53 to modulate apoptosis.". Paper presented in 15th Euroconference on Apoptosis of the European Cell Death Organization, 2007.
  23. Solá S, Amaral JD, Borralho PM, Ramalho RM, Castro RE, Aranha MM, Steer CJ, Rodrigues CMP.. "Inhibition of nuclear steroid receptor expression by small interference RNA modulates the anti-apoptotic effect of tauroursodeoxycholic acid in rat cortical neurons.". Paper presented in Keystone Symposium – MicroRNAs and siRNAs: Biological Functions and Mechanisms, 2007.
  24. Castro RE, Amaral JD, Solá S, Kren BT, Rodrigues CMP, Steer CJ.. "Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes.". Paper presented in Annual Research Day Meeting, University of Minnesota, 2007.
  25. Amaral, JD; Castro RE, Solá S, Rodrigues CMP.. "Bile acids modulate p53 transcriptional targeting in primary rat hepatocytes.". Paper presented in Cell Signaling World 2006, 2006.
  26. Amaral, JD; Castro RE, Nan Z, Aranha MM, Steer CJ, Low WC, Rodrigues CMP.. "In vitro modulation of 6-hydroxydopamine neuronal death by an endogenous bile acid.". Paper presented in 6th ESH - UT MD Anderson Cancer Center Interdisciplinary Euroconference on Mechanisms of Cell Death and Disease: Advances in Therapeutic Intervention and Drug Development, 2006.
  27. Solá S, Amaral JD, Borralho PM, Ramalho RM, Castro RE, Aranha MM, Steer CJ, Rodrigues CMP.. "Small interference RNA against nuclear steroid modulates the anti-apoptotic effect of tauroursodeoxycholic acid in rat cortical neurons.". Paper presented in 6th ESH-UT MD Anderson Cancer Center International Conference on “Mechanisms of Cell Death and Disease: Advances in Therapeutic Intervention and Drug Development, 2006.
  28. Solá S, Amaral JD, Borralho PM, Ramalho RM, Castro RE, Aranha MM, Steer CJ, Rodrigues CMP.. "Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis.". Paper presented in 5th Forum of European Neuroscience, 2006.
  29. Castro RE, Amaral JD, Borralho PM, Solá S, Kren BT, Steer CJ, Rodrigues CMP.. "Selective targeting of cyclin D1 by bile acids influences their ability to modulate apoptosis in primary rat hepatocytes.". Paper presented in 14th Euroconference on Apoptosis of the European Cell Death Organization, 2006.
Journal article
  1. Gonçalves, Joana; Amaral, JD; Capela, Rita; Perry, Maria Jesus; Braga, Cláudia; Gaspar, Maria Manuela; Piedade, Fátima; et al. Corresponding author: Rodrigues, Cecília. "Necroptosis Induced by Ruthenium (II) Complexes as Mitochondrial Disruptors". (2024):
    Submitted
  2. André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra I.; Leonardo, Ana; Nogueira, Sara; Amaral, JD; Fernandes, Célia; et al. "Panobinostat-loaded folate targeted liposomes as a promising drug delivery system for treatment of canine B-cell lymphoma". Frontiers in Veterinary Science 10 (2023): http://dx.doi.org/10.3389/fvets.2023.1236136.
    10.3389/fvets.2023.1236136
  3. Pinho, Jacinta O.; Matias, Mariana; Godinho-Santos, Ana; Amaral, JD; Mendes, Eduarda; Perry, Maria Jesus; Francisco, Ana Paula; Rodrigues, Cecília M.P.; Gaspar, M. Manuela. Corresponding author: Gaspar, M. Manuela. "A step forward on the in vitro and in vivo assessment of a novel nanomedicine against melanoma". International Journal of Pharmaceutics 640 (2023): 123011. http://dx.doi.org/10.1016/j.ijpharm.2023.123011.
    10.1016/j.ijpharm.2023.123011
  4. Pinho, Jacinta O.; Matias, Mariana; Marques, Vanda; Eleutério, Carla; Fernandes, Célia; Gano, Lurdes; Amaral, JD; et al. "Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management". Biomedicine & Pharmacotherapy 157 (2023): 114021. http://dx.doi.org/10.1016/j.biopha.2022.114021.
    Published • 10.1016/j.biopha.2022.114021
  5. Espadinha, Margarida; Lopes, Elizabeth A.; Marques, Vanda; Amaral, JD; dos Santos, Daniel J.V.A.; Mori, Mattia; Daniele, Simona; et al. "Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors". European Journal of Medicinal Chemistry 241 (2022): 114637. http://dx.doi.org/10.1016/j.ejmech.2022.114637.
    Published • 10.1016/j.ejmech.2022.114637
  6. Aniceto, Natália; Marques, Vanda; Amaral, JD; Serra, Patrícia A.; Moreira, Rui; Rodrigues, Cecília M. P.; Guedes, Rita C.. "Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors". Molecules 27 15 (2022): 4718. http://dx.doi.org/10.3390/molecules27154718.
    Published • 10.3390/molecules27154718
  7. Jacinta O. Pinho; Inês V. da Silva; Joana D. Amaral; Cecília M.P. Rodrigues; Angela Casini; Graça Soveral; Maria Manuela Gaspar. "Therapeutic potential of a copper complex loaded in pH-sensitive long circulating liposomes for colon cancer management". International Journal of Pharmaceutics (2021): https://doi.org/10.1016/j.ijpharm.2021.120463.
    10.1016/j.ijpharm.2021.120463
  8. Sara R. Oliveira; Pedro A. Dionísio; Maria M. Gaspar; Leonor Correia Guedes; Miguel Coelho; Mário M. Rosa; Joaquim J. Ferreira; Joana D. Amaral; Cecília M. P. Rodrigues. "miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson’s Disease". Frontiers in Cell and Developmental Biology (2021): https://publons.com/publon/47508971/.
    10.3389/FCELL.2021.661461
  9. Dionisio, P. A.; Amaral, J. D.; Rodrigues, C. M. P.. "Oxidative stress and regulated cell death in Parkinson's disease". Ageing Research Reviews (2021): https://publons.com/publon/39386485/.
    10.1016/J.ARR.2021.101263
  10. Sara R. Oliveira; Pedro A. Dionísio; Maria M. Gaspar; Maria B. T. Ferreira; Catarina A. B. Rodrigues; Rita G. Pereira; Mónica S. Estevão; et al. "Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice". International Journal of Molecular Sciences (2021): https://publons.com/publon/36314428/.
    10.3390/IJMS22105289
  11. Oliveira, Sara R.; Dionísio, Pedro A.; Correia Guedes, Leonor; Gonçalves, Nilza; Coelho, Miguel; Rosa, Mário M.; Amaral, Joana D.; Ferreira, Joaquim J.; Rodrigues, Cecília M. P.. "Circulating Inflammatory miRNAs Associated with Parkinson’s Disease Pathophysiology". Biomolecules 10 6 (2020): 945. http://dx.doi.org/10.3390/biom10060945.
    Published • 10.3390/biom10060945
  12. Santos-Rebelo, Ana; Kumar, Pradeep; Pillay, Viness; Choonara, Yahya E.; Eleutério, Carla; Figueira, Mariana; Viana, Ana S.; et al. "Development and Mechanistic Insight into the Enhanced Cytotoxic Potential of Parvifloron D Albumin Nanoparticles in EGFR-Overexpressing Pancreatic Cancer Cells". Cancers 11 11 (2019): 1733. http://dx.doi.org/10.3390/cancers11111733.
    Published • 10.3390/cancers11111733
  13. Pedro A. Dionísio; Sara R. Oliveira; Maria M. Gaspar; Maria J. Gama; Margarida Castro-Caldas; Joana D. Amaral; Cecilia M. P. Rodrigues. "Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson’s disease". Cell Death & Disease 10 11 (2019): https://doi.org/10.1038/s41419-019-2078-z.
    10.1038/s41419-019-2078-z
  14. Jacinta O Pinho; Joana D Amaral; Rui E Castro; Cecília MP Rodrigues; Angela Casini; Graça Soveral; Maria Manuela Gaspar. "Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models". Nanomedicine 14 7 (2019): 835-850. https://doi.org/10.2217%2Fnnm-2018-0388.
    10.2217/nnm-2018-0388
  15. Joana D. Amaral; Dário Silva; Cecília M. P. Rodrigues; Susana Solá; Maria M. M. Santos. "A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation". Frontiers in Chemistry 7 (2019): https://doi.org/10.3389%2Ffchem.2019.00015.
    10.3389/fchem.2019.00015
  16. Dionisio, Pedro A.; Oliveira, Sara R.; Amaral, Joana D.; Rodrigues, Cecilia M. P.. "Tuning cell death in neuroinflammation". European Journal of Clinical Investigation (2019): https://publons.com/publon/30227155/.
  17. Amaral, Joana D.; Dionisio, Pedro A.; Oliveira, Sara R.; Rodrigues, Cecilia M. P.. "Genetic ablation of RIP3 protects from dopaminergic neuronal death in the MPTP-mouse model of Parkinson's disease". Cell Death Discovery (2019): https://publons.com/publon/30227161/.
  18. Amaral, Joana D.; Silva, Dario; Rodrigues, Cecilia M. P.; Sola, Susana; Santos, Maria M. M.. "[Correction] A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation (vol 7, 15, 2019)". Frontiers in Chemistry (2019): https://publons.com/publon/30227121/.
    10.3389/FCHEM.2019.00282
  19. Sara R. Oliveira; Joana D. Amaral; Cecília M. P. Rodrigues. "Mechanism and disease implications of necroptosis and neuronal inflammation". Cell Death & Disease 9 9 (2018): https://doi.org/10.1038/s41419-018-0872-7.
    10.1038/s41419-018-0872-7
  20. Sara R. Oliveira; Pedro A. Dionísio; Hugo Brito; Lídia Franco; Catarina A. B. Rodrigues; Rita C. Guedes; Carlos A. M. Afonso; Joana D. Amaral; Cecília M. P. Rodrigues. "Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation". Cell Death Discovery 5 1 (2018): https://doi.org/10.1038%2Fs41420-018-0067-0.
    10.1038/s41420-018-0067-0
  21. Dionisio, Pedro Eloi Antunes; Oliveira, Sara Rodrigues; Amaral, Joana Sao Jose Dias; Rodrigues, Cecilia Maria Pereira. "Loss of Microglial Parkin Inhibits Necroptosis and Contributes to Neuroinflammation.". Molecular neurobiology (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:30074231&KeyUID=MEDLINE:30074231.
    10.1007/s12035-018-1264-9
  22. Nunes, R.C.; Ribeiro, C.J.A.; Monteiro, Â.; Rodrigues, C.M.P.; Amaral, J.D.; Santos, M.M.M.. "In vitro targeting of colon cancer cells using spiropyrazoline oxindoles". European Journal of Medicinal Chemistry 139 (2017): 168-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026814888&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.07.057
  23. Ribeiro, C.J.A.; Nunes, R.C.; Amaral, J.D.; Gonçalves, L.M.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties". European Journal of Medicinal Chemistry 140 (2017): 494-509. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030537870&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.09.037
  24. da Costa, M.; Bernardi, J.; Costa, L.; Fiuza, T.; Brandão, R.; Ribeiro, M.F.; Amaral, J.D.; Rodrigues, C.M.P.; Pereira, M.E.. "N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin". Chemico-Biological Interactions 272 (2017): 37-46. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019180713&partnerID=MN8TOARS.
    10.1016/j.cbi.2017.05.008
  25. Ribeiro, C.J.A.; Amaral, J.D.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Spirooxadiazoline oxindoles with promising in vitro antitumor activities". MedChemComm 7 3 (2016): 420-425. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961801651&partnerID=MN8TOARS.
    10.1039/c5md00450k
  26. Afonso, M.B.; Rodrigues, P.M.; Simão, A.L.; Ofengeim, D.; Carvalho, T.; Amaral, J.D.; Gaspar, M.M.; et al. "Activation of necroptosis in human and experimental cholestasis". Cell Death and Disease 7 9 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019011199&partnerID=MN8TOARS.
    10.1038/cddis.2016.280
  27. Dionísio, P.A.; Amaral, J.D.; Ribeiro, M.F.; Lo, A.C.; D'Hooge, R.; Rodrigues, C.M.P.. "Amyloid-ß pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset". Neurobiology of Aging 36 1 (2015): 228-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920453379&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2014.08.034
  28. Ribeiro, C.J.A.; Amaral, J.D.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents". Bioorganic and Medicinal Chemistry 22 1 (2014): 577-584. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891490447&partnerID=MN8TOARS.
    10.1016/j.bmc.2013.10.048
  29. Ramalho, R.M.; Nunes, A.F.; Dias, R.B.; Amaral, J.D.; Lo, A.C.; D'Hooge, R.; Sebastião, A.M.; Rodrigues, C.M.P.. "Tauroursodeoxycholic acid suppresses amyloid ß-induced synaptic toxicity in vitro and in APP/PS1 mice". Neurobiology of Aging 34 2 (2013): 551-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869091863&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2012.04.018
  30. Simões, A.E.S.; Pereira, D.M.; Amaral, J.D.; Nunes, A.F.; Gomes, S.E.; Rodrigues, P.M.; Lo, A.C.; et al. "Efficient recovery of proteins from multiple source samples after trizol®or trizol®LS RNA extraction and long-term storage". BMC Genomics 14 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874944258&partnerID=MN8TOARS.
    10.1186/1471-2164-14-181
  31. Amaral, J.D.; Herrera, F.; Rodrigues, P.M.; Dionísio, P.A.; Outeiro, T.F.; Rodrigues, C.M.P.. "Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system". Biochemical Pharmacology 85 6 (2013): 745-752. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874114339&partnerID=MN8TOARS.
    10.1016/j.bcp.2012.12.009
  32. Nunes, A.F.; Amaral, J.D.; Lo, A.C.; Fonseca, M.B.; Viana, R.J.S.; Callaerts-Vegh, Z.; D'Hooge, R.; Rodrigues, C.M.P.. "TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-ß deposition in APP/PS1 mice". Molecular Neurobiology 45 3 (2012): 440-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867485621&partnerID=MN8TOARS.
    10.1007/s12035-012-8256-y
  33. Amaral, J.D.; Xavier, J.M.; Steer, C.J.; Rodrigues, C.M.P.. "Targeting the p53 pathway of apoptosis". Current Pharmaceutical Design 16 22 (2010): 2493-2503. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955630266&partnerID=MN8TOARS.
    10.2174/138161210791959818
  34. Amaral, J.D.; Correia, A.R.; Steer, C.J.; Gomes, C.M.; Rodrigues, C.M.P.. "No evidence of direct binding between ursodeoxycholic acid and the p53 DNA-binding domain". Bioscience Reports 30 5 (2010): 359-364. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954733196&partnerID=MN8TOARS.
    10.1042/BSR20090107
  35. Amaral, J.D.; Castro, R.E.; Solá, S.; Steer, C.J.; Rodrigues, C.M.P.. "Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53". Biochemical and Biophysical Research Communications 400 4 (2010): 649-654. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957258575&partnerID=MN8TOARS.
    10.1016/j.bbrc.2010.08.121
  36. Amaral, J.D.; Xavier, J.M.; Steer, C.J.; Rodrigues, C.M.. "The role of p53 in apoptosis.". Discovery medicine 9 45 (2010): 145-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952554792&partnerID=MN8TOARS.
  37. "The Role of p53 in Apoptosis". Discovery Medicine (2010): https://publons.com/publon/11694532/.
    10.1201/9781482295276-11
  38. Amaral, J.D.; Castro, R.E.; Steer, C.J.; Rodrigues, C.M.P.. "p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis". Trends in Molecular Medicine 15 11 (2009): 531-541. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449109071&partnerID=MN8TOARS.
    10.1016/j.molmed.2009.09.005
  39. Amaral, J.D.; Viana, R.J.S.; Ramalho, R.M.; Steer, C.J.; Rodrigues, C.M.P.. "Bile acids: Regulation of apoptosis by ursodeoxycholic acid". Journal of Lipid Research 50 9 (2009): 1721-1734. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350417325&partnerID=MN8TOARS.
    10.1194/jlr.R900011-JLR200
  40. Amaral, J.D.; Solá, S.; Steer, C.J.; Rodrigues, C.M.P.. "Role of nuclear steroid receptors in apoptosis". Current Medicinal Chemistry 16 29 (2009): 3886-3902. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450193159&partnerID=MN8TOARS.
    10.2174/092986709789178028
  41. Amaral, J.D.; Solá, S.; Steer, C.J.; Rodrigues, C.P.. "Function of nuclear steroid receptors in apoptosis: Role of ursodeoxycholic acid". Expert Review of Endocrinology and Metabolism 2 4 (2007): 487-501. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547549183&partnerID=MN8TOARS.
    10.1586/17446651.2.4.487
  42. Castro, R.E.; Amaral, J.D.; Solá, S.; Kren, B.T.; Steer, C.J.; Rodrigues, C.M.P.. "Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes". American Journal of Physiology - Gastrointestinal and Liver Physiology 293 1 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-34547109141&partnerID=MN8TOARS.
    10.1152/ajpgi.00093.2007
  43. Amaral, J.D.; Castro, R.E.; Solá, S.; Steer, C.J.; Rodrigues, C.M.P.. "p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis". Journal of Biological Chemistry 282 47 (2007): 34250-34259. http://www.scopus.com/inward/record.url?eid=2-s2.0-36348941176&partnerID=MN8TOARS.
    10.1074/jbc.M704075200
  44. Solá, S.; Amaral, J.D.; Aranha, M.M.; Steer, C.J.; Rodrigues, C.M.P.. "Modulation of hepatocyte apoptosis: Cross-talk between bile acids and nuclear steroid receptors". Current Medicinal Chemistry 13 25 (2006): 3039-3051. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749433408&partnerID=MN8TOARS.
    10.2174/092986706778521823
  45. Solá, S.; Amaral, J.D.; Borralho, P.M.; Ramalho, R.M.; Castro, R.E.; Aranha, M.M.; Steer, C.J.; Rodrigues, C.M.P.. "Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid ß-peptide-induced apoptosis". Molecular Endocrinology 20 10 (2006): 2292-2303. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749332011&partnerID=MN8TOARS.
    10.1210/me.2006-0063
  46. Freire, P.; Amaral, J.D.; Santos, J.M.; Arraiano, C.M.. "Adaptation to carbon starvation: RNase III ensures normal expression levels of bolA1p mRNA and sS". Biochimie 88 3-4 (2006): 341-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644841173&partnerID=MN8TOARS.
    10.1016/j.biochi.2005.09.004
  47. Solá, S.; Garshelis, D.L.; Amaral, J.D.; Noyce, K.V.; Coy, P.L.; Steer, C.J.; Iaizzo, P.A.; Rodrigues, C.M.P.. "Plasma levels of ursodeoxycholic acid in black bears, Ursus americanus: Seasonal changes". Comparative Biochemistry and Physiology - C Toxicology and Pharmacology 143 2 (2006): 204-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646196447&partnerID=MN8TOARS.
    10.1016/j.cbpc.2006.02.002
  48. Solá, S.; Amaral, J.D.; Castro, R.E.; Ramalho, R.M.; Borralho, P.M.; Kren, B.T.; Tanaka, H.; Steer, C.J.; Rodrigues, C.M.P.. "Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-ß1-induced apoptosis in rat hepatocytes". Hepatology 42 4 (2005): 925-934. http://www.scopus.com/inward/record.url?eid=2-s2.0-25844516609&partnerID=MN8TOARS.
    10.1002/hep.20870
Thesis / Dissertation
  1. Amaral, JD. "p53, a novel molecular target of ursodeoxycholic acid in modulating hepatocyte apoptosis". PhD, Universidade de Lisboa Faculdade de Farmácia, 2008.
  2. Amaral, JD. "Construção de Recombinantes NAT2 e Expressão Heteróloga em Células de Mamífero – Definição de um modelo para o estudo de factores genéticos e ambientais de susceptibilidade a Doenças Neurodegenerativas". Degree, Universidade de Lisboa Faculdade de Ciências, 2002.
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/05/14 - Current "O Cérebro Trocado em Miúdos", science outreach event organized in collaboration with the Natural History and Science Museum (MUHNAC), within the framework of the Brain Awareness Week global campaign. Family-oriented leisure activities about how our brains work, why learning about that matters, and how they can behave to protect it. Activies organized in different work stations intended to be both fun and educational. - (2023/05/14)
Other (Other)
 Universidade de Lisboa Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/12/21 REDOX REGULATION OF MITOCHONDRIAL DYNAMICS AND FUNCTION IN PARKINSON’S DISEASE
(Thesis) Arguer
 Fabiana Alexandra Carvalho dos Santos (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/12/19 CYTOTOXICITY OF MARINE FUNGI EXTRACTS ON COLORECTAL CANCER CELLS AND RELATED MECHANISMS OF ACTION
(Thesis) Arguer
 Mariana Ramos da Costa Atalaia (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/10/06 TARGETING NEUROINFLAMMATION AND NEURODEGENERATION IN PARKINSON’S DISEASE
Supervisor
 Sara Rodrigues Oliveira (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/10/04 Design, synthesis and biological evaluation of novel p53 activators by targeting p53 protein-protein interactions
(Thesis) Arguer
 Margarida Leonor Florindo Espadinha (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
Distinctions

Award

2023 Brain Awareness Week Grant 2023
Dana Foundation, United States

Federation of European Neuroscience Societies, Belgium
2020 Best Oral Presentation
Ordem dos Farmaceuticos, Portugal