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I am a physician (FMUSP, BR, 1999) with specialisations in General and Internal Medicine (HCFMUSP, BR, 2003) and Travel Medicine (IHMT NOVA, PT, 2018) and a scientist in the field of Medical and Health Sciences with a PhD in Science/Host-Pathogen Interactions (ICBUSP, BR, 2011). As a doctoral researcher in some Portuguese institutions of the highest international prestige, I have shown: 1. The participation of immunoregulatory mechanisms in the sequestration phenomenon of Plasmodium-infected erythrocytes using an experimental rodent model and intra-vital microscopy (https://doi.org/10.1371/journal.pone.0081409), 2. The molecular mechanisms observed in enzymopathies implicated in erythrocyte resistance to malaria infection, shedding light on host-directed therapies (https://doi.org/10.3389/fcimb.2022.840968, https://doi.org/10.3390/ijms24021336) 3. The effect of new compounds and repurposed drugs on Plasmodium development in the invertebrate host and on liver and blood stages of malaria infection in experimental rodent models, (https://doi.org/10.3390/plants12040963) 4. The association between revaccination with the bivalent live-attenuated oral polio vaccine (OPV) and a healthier microbiome composition in the gut and upper respiratory tract of revaccinated infants, that could drive OPV non-specific effects to unrelated pathogens (https://doi.org/10.3389/fmicb.2022.1016220). As an assistant researcher at the IHMT-NOVA, my current research interests focus on: 1. The genetic diversity of Plasmodium falciparum parasites in low-density infections and the contribution of low-density infections to the maintenance of malaria transmission in pre-elimination malaria settings in sub-Saharan Africa (SUBFAM protocol in collaboration with the Bandim Health Project in Guinea-Bissau) - I have been supervising a PhD student at IHMT NOVA (PhD Programme in Global Health and Tropical Diseases) in this project, who received a PhD scholarship (UI/BD/151069/2021, in progress) from the Portuguese National Foundation for Science and Technology, FCT. 2. The development of point-of-care technologies based on isothermal amplification of nucleic acids for the diagnosis of Plasmodium infections – (Project DxHub -HORIZON-WIDERA-2023-ACCESS-07) 3. The development of point-of-care technologies based on isothermal amplification of nucleic acids for the identification of antimalarial resistant Plasmodium parasites (RESMALDETECT project in collaboration with researchers from the University of Rovira i Virgili, Tarragona, Spain) - I have been supervising a Master's student at IHMT NOVA (Master in Medical Parasitology) who is developing her Master dissertation within this project. As a medical doctor at the IHMT-NOVA, I have done pre-travel consultations at the ADMT (Tropical Medicine Development Association) Travellers' Clinic since 2022.
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Identification

Personal identification

Full name
Márcia Melo Medeiros

Citation names

  • Medeiros, Márcia Melo
  • Medeiros, MM
  • Márcia M. Medeiros

Author identifiers

Ciência ID
641A-91BB-0CDA
ORCID iD
0000-0002-5364-9087
Scopus Author Id
55975207300

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Parasitology
  • Medical and Health Sciences - Clinical Medicine - General and Internal Medicine
  • Natural sciences - Biological Sciences - Microbiology
  • Medical and Health Sciences - Health Sciences - Tropical Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2018/04/20 - 2018/08/13
Concluded
 Travel Medicine (Título de especialista)
Major in Travel Medicine - Tropical Medicine
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 15
2007/01/01 - 2011/11/17
Concluded
 Sciences - Biology of Host and Pathogen Interactions (Doktor (PhD))
Major in Parasitolgy - Malaria - Plasmodium falciparum
The University of São Paulo - Insitute of Biomedical Sciences, Brazil
"Humoral immune response profile of symptomatic and asymptomatic patients of falciparum malaria, from Western Brazilian Amazon, against polymorphic antigens exported to the surface of infected erythrocyte and merozite expressed antigens." (THESIS/DISSERTATION)
 Approved - Excellent
2001/02/01 - 2003/01/31
Concluded
 General and Internal Medicine (Doctor)
Major in Specialist in General and Internal Medicine
The University of São Paulo Medical School, Brazil
 Approved
1993/01 - 1999/10/27
Concluded
 Medicine (Master Universitario)
Major in Medicine- Equivalent to Integrated Master in Medicine by University of Lisbon Medical School.
The University of São Paulo Medical School, Brazil
 Approved - (7.5/10 or 15/20)
Affiliation

Science

Category
Host institution 		Employer
2023/04/01 - Current Auxiliary Researcher (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2022/04/01 - 2022/09/30 Contracted Researcher (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
(...)
2019/04/01 - 2021/09/30 Contracted Researcher (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal
(...)
2017/03/13 - 2019/03/31 Postdoc (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal
2013/02/16 - 2016/06/30 Postdoc (Research) Instituto de Medicina Molecular João Lobo Antunes, Portugal
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2012/01/02 - 2012/11/30 Postdoc (Research) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES, Brazil
Instituto Gulbenkian de Ciência, Portugal
2004/08/01 - 2006/08/19 Research Assistant (Research) Fundação Oswaldo Cruz - Rondônia, Brazil
Fundação Oswaldo Cruz - Rondônia, Brazil
(...)

Other Careers

Category
Host institution 		Employer
2003/04/01 - 2003/12/31 Assistente graduado (Médica) Ministry of Health - Brazil, Brazil
Public Center of Primary Health Care of Campos Belos de Goiás - Goiás - Brasil, Brazil
1999/12/01 - 2000/08/01 Assistente graduado (Médica) Ministry of Health - Brazil, Brazil
Public center of Primary Health Care of Sobral - Ceará - Brazil, Brazil
Projects

Grant

Designation Funders
2023/09 - Current RESMALDETECT - Rapid Detection Of Single Nucleotide Polymorphisms (SNPs) Associated With Drug-resistant Malaria Using An Isothermal Amplification Approach
UIDB/04413/2020/RESMALDETECT
Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universitat Rovira i Virgili, Spain
Universidade Nova de Lisboa Saúde Global e Medicina Tropical
Ongoing
2017/03/13 - 2019/03/31 MicroOPV: assessing the effect of oral poliomyelitis vaccine (OPV) on microbiomes of gut and upper respiratory tract of Bissau-Guinean infants.
UID/Multi/04413/2013
Post-doc Fellow
Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal

Bandim Health Project, Guinea-Bissau

Statens Serum Institute, Denmark

Syddansk Universitet, Denmark
Fundação para a Ciência e a Tecnologia
Concluded
2013/03/01 - 2016/06/30 Host-Plasmodium interactions: a tale of sensing and being sensed.
EXCL/IMIMIC/0056/2012
Post-doc Fellow
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/12/26 - 2012/12/21 Biology of regulatory T cells in a murine experimental model of malaria infection
5677/11-4
Post-doc Fellow
Instituto Gulbenkian de Ciência, Portugal
 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Concluded
2007/01/18 - 2011/11/17 Perfil da resposta imune humoral de pacientes sintomáticos e assintomáticos para malária falciparum, da Amazônia Ocidental Brasileira, contra antígenos polimórficos exportados para a superfície da hemácia infectada e antígenos expressos no merozoíto.
06/56241-2
PhD Student Fellow
The University of São Paulo - Insitute of Biomedical Sciences, Brazil

Fundação Oswaldo Cruz - Rondônia, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded

Contract

Designation Funders
2022/03/21 - 2022/09/30 MALREP - Identification of new antimalarial treatments through a target-centred "drug repositioning" approach
PTDC_SAU_PAR_28459_2017
Research Fellow
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/04/01 - 2021/09/30 PlasmDPG - When the host cell is not so cosy anymore… A drop off in energy or an increase in toxicity?
PTDC/BIA -CEL/28456/2017
Research Fellow
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Saúde Global e Medicina Tropical
UID/Multi/04413/2019
Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal

Universidade Nova de Lisboa, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2019 - 2023 SUBFAM - Submicroscopic Plasmodium falciparum infections: a barrier to malaria elimination?
SUBFAM
Principal investigator
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Bandim Health Project, Guinea-Bissau
Ongoing
Outputs

Publications

Book chapter
  1. Medeiros, MM. "Microbioma respiratório saudável: um projeto inovador na primeira coorte de nascimento em Angola". 2018.
    10.25761/ANAISIHMT.65
Conference poster
  1. Ana Balau; Sobral, Daniel; Márcia M. Medeiros; Antunes, Sandra; Carvalho, Maria; Inês Navalho Morais; Filomena Aréde de Carvalho; et al. "Turning a vulnerability into a strength - deciphering the protective mechanisms of pyruvate kinase deficiency against malaria". Paper presented in EMBL Conference: BioMalPar XX: biology and pathology of the malaria parasite, 2024.
  2. Silva, Ronise; Rodrigues, Amabelia; Ana Paula Arez; Medeiros, MM. "Reassessing malaria epidemiology in a pre-elimination setting by exploring a multiple targeting strategy on the parasite 18S rRNA gene". Paper presented in XIV Jornadas Cientificas do IHMT NOVA, 2023.
  3. Mariana Pinto [6F1D-8422-5B85]; Ana Lopes Tavares; Mayreli Ortiz; Vasoula Skouridou; Miriam Jauset-Rubio; Viveiros, Miguel; Ana Paula Arez; Ciara K. O' Sullivan; Márcia M. Medeiros. Corresponding author: Márcia M. Medeiros. "Rapid detection of Single Nucleotide Polymorphisms associated with drugresistance in malaria parasites using isothermal amplification approach .". Paper presented in Congress of Microbiology and Biotechnology 2023 (Microbiotec'23), 2023.
  4. Balau, Ana; Sobral, Daniel; Abrantes, Patrícia; Carvalho, Maria; Morais, Inês; Mixão, Verónica; Medeiros, Márcia Melo; et al. "Unveiling the Protective Mechanisms of Pyruvate Kinase Deficiency against Malaria: Transforming Vulnerability into Resilience". Paper presented in MicroBiotec 2023, 2023.
  5. Silva, Ronise; Rodrigues, Amabelia; Ana Paula Arez; Márcia M. Medeiros. "The importance of the genomic analysis of host and pathogens for malaria control and elimination". Paper presented in 16th International Conference on Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases, 2023.
  6. Silva, Ronise; Rodrigues, Amabelia; Ana Paula Arez; Medeiros, MM. "Low-density malaria infections: are they important to sustain malaria in Guinea-Bissau?". Paper presented in India EMBO Lecture Course. Malaria molecular epidemiology, population genetics, and evolution: Principles to practices, 2022.
  7. Silva, Ronise; Rodrigues, Amabelia; Ana Paula Arez; Medeiros, MM. "Low-density malaria infections: are they important to sustain malaria in Guiné-Bissau?". Paper presented in Encontro Ciência 2022, 2022.
  8. Ana Lopes Tavares; Miguel Lanaspa, MD, PhD; Line Møller Pedersen; Claudino Correia; Ane Baerent Fisker, PhD; Christine Stabell Benn, PhD; Ana Paula Arez; Medeiros, MM. "Biotropical Resources - GHTM/IHMT NOVA Biobank: Biobanking African Pedriatic Upper Respiratory and Gut Microbiomes". Paper presented in IV International Conference NOVAhealth Chronic Disease and Infection - Microbiota and Health, 2021.
  9. Medeiros, Márcia Melo; Anna Cäcilia Ingham; Line Møller Pedersen; Claudino Correia; Marc Stegger; Paal Skyt Andersen; Ane Baerent Fisker; et al. Corresponding author: Medeiros, Márcia Melo. "Oral poliomyelitis revaccination is associated with changes in gut and upper respiratory microbiomes of infants". Paper presented in Microbiotec21 - Webconference, 2021.
  10. Ana Tavares; Line Møller Pedersen; Claudino Correia; Ane Baerent Fisker; Christine Stabell Benn; Ana Paula Arez; Medeiros, MM. "Biotropical Resources (GHTM/IHMT NOVA biobank): Biobanking African Pedriatic Upper Respiratory and Gut Microbiomes". Paper presented in Microbiotec21 - Webconference, 2021.
  11. Inês Morais; Medeiros, MM; Maria Carvalho; Ana Paula Arez. "The effect of 2,3-diphosphoglycerate (2,3-DPG) on malaria parasite development: is there a potential for a host-directed therapy tool?". Paper presented in III International Conference NOVAhealth Chronic Disease and Infection “Infection, Cancer and Global Health, 2020.
  12. Maria Carvalho; Catarina S Lopes; Inês Morais; Medeiros, MM; Nuno C Santos; Filomena A. Carvalho, PhD; Ana Paula Arez. "Protective effect of red blood cell pyruvate kinase deficiency against malaria: is there a role for the host cell membrane?". Paper presented in III International Conference NOVAhealth Chronic Disease and Infection “Infection, Cancer and Global Health", 2020.
    https://novahealth-chronicdiseaseandinfection.unl.pt/past-conference/2020/sites/default/files/inline-files/28-09livreto_iii_ic_cdi_09102020.pdf)
  13. Julyana Cerqueira Buery; A.M.R.C. Duarte; F.E.C. Alencar; C. Furieri; S.L. Mendes; A.C. Loss; C.R. Vicente; et al. "One piece more in the puzzle of Plasmodium simium and Plasmodium vivax identity: detection of P. vivax in a liver sample of a howler-monkey". Paper presented in III International Conference NOVAhealth Chronic Disease and Infection - Infection, Cancer and Global Health, 2020.
  14. Medeiros, MM; Wesley Luzetti Fotoran, PhD; Rosimeire Dalla-Martha, PhD; Prof. Gerhard Wunderlich, PhD. "PLASMODIUM FALCIPARUM MEROZOITE ANTIGENS ASSOCIATED TO PROTECTION FROM NATURALLY ACQUIRED IMMUNE RESPONSE IN THE BRAZILIAN AMAZON.". Paper presented in XXVII Reunião Anual da Sociedade Brasileira de Protozoologia XXXVIII Reunião Anual sobre Pesquisa básica em Doença de Chagas, 2011.
  15. Medeiros, MM; Wesley Luzetti Fotoran, PhD; Rosimeire Dalla-Martha, PhD; Prof. Gerhard Wunderlich, PhD. "HUMORAL IMMUNE RESPONSE AGAINST Plasmodium falciparum MEROZOITE SURFACE PROTEINS MSP2, MSP3, MSP5 IS ASSOCIATED WITH ASYMPTOMATIC INFECTIONS IN WESTERN BRAZILIAN AMAZON.". Paper presented in XII Reunião Nacional de Pesquisa em Malária, 2010.
  16. Medeiros, MM; Catarina Castineiras, PhD; Prof. Gerhard Wunderlich, PhD; Medeiros, Márcia Melo; Catarina Castineiras; Gehrard Wunderlich. "Expression of recombinant proteins from trophozoites and merozoites of Plasmodium falciparum isolates from Brazilian Amazon and immune response analysis.". Paper presented in American Society of Tropical Medicine and Hygiene 58th Annual Meeting, 2009.
    https://doi.org/10.4269/ajtmh.2009.81.51
  17. Medeiros, MM; Prof. Gerhard Wunderlich, PhD. "Expression of recombinant SURFIN proteins of Plasmodium falciparum isolates from Brazilian Amazon and immune response analysis.". Paper presented in XXIV Meeting of the Brazilian Society of Protozoology XXXV Annual Meeting on Basic Research in Chagas Disease, 2008.
  18. Medeiros, MM; Prof. Gerhard Wunderlich, PhD. "Analysis of surf gene family in Plasmodium falciparum field isolates.". Paper presented in XXIII Meeting of the Brazilian Society of Protozoology XXXIV Annual Meeting on Basic Research in Chagas Disease, 2007.
Journal article
  1. Silva, Ronise; Lopes, Luis Filipe; Rodrigues, Amabelia; Arez, Ana Paula; Medeiros, Márcia M.. Corresponding author: Medeiros, Márcia M.. "Assessing the burden of submicroscopic Plasmodium infections in a pre-elimination malaria setting in sub-Saharan Africa, Guinea-Bissau". Malaria Journal 23 1 (2024): http://dx.doi.org/10.1186/s12936-024-05138-z.
    Open access • Published • 10.1186/s12936-024-05138-z
  2. Essoh, Anyse P.; Cassiano, Gustavo Capatti; Mandim, Filipa; Barros, Lillian; Gomes, Isildo; Medeiros, Márcia Melo; Moura, Mónica; Cravo, Pedro Vitor Lemos; Romeiras, Maria M.. "Antimalarial and Cytotoxic Activity of Native Plants Used in Cabo Verde Traditional Medicine". Plants 12 4 (2023): 963. http://dx.doi.org/10.3390/plants12040963.
    Open access • Published • 10.3390/plants12040963
  3. Carvalho, Maria; Medeiros, MM; Morais, Inês; Lopes, Catarina S.; Balau, Ana; Santos, Nuno C.; Carvalho, Filomena A.; Arez, Ana Paula. "2,3-Diphosphoglycerate and the Protective Effect of Pyruvate Kinase Deficiency against Malaria Infection—Exploring the Role of the Red Blood Cell Membrane". International Journal of Molecular Sciences 24 2 (2023): 1336. http://dx.doi.org/10.3390/ijms24021336.
    Open access • Published • 10.3390/ijms24021336
  4. Tavares, Wilson; Morais, Joana; Martins, José F.; Scalsky, Ryan J.; Stabler, Thomas C.; Medeiros, Márcia M.; Fortes, Filomeno J.; Arez, Ana Paula; Silva, Joana C.. "Malaria in Angola: recent progress, challenges and future opportunities using parasite demography studies". Malaria Journal 21 1 (2022): http://dx.doi.org/10.1186/s12936-022-04424-y.
    Open access • Published
  5. Medeiros, Márcia Melo; Ingham, Anna Cäcilia; Nanque, Line Møller; Correia, Claudino; Stegger, Marc; Andersen, Paal Skyt; Fisker, Ane Baerent; et al. "Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.1016220.
    Published • 10.3389/fmicb.2022.1016220
  6. Morais, Inês Navalho; Medeiros, MM; Carvalho, Maria; Morello, Judit; Teixeira, Sara M.; Maciel, Suelma; Nhantumbo, Janice; et al. "Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerate (2,3-DPG) Inhibits Plasmodium falciparum Development In Vitro". Frontiers in Cellular and Infection Microbiology 12 (2022): http://dx.doi.org/10.3389/fcimb.2022.840968.
    Published • 10.3389/fcimb.2022.840968
  7. Buery, Julyana Cerqueira; de Alencar, Filomena Euridice Carvalho de; Duarte, Ana Maria Ribeiro de Castro; Loss, Ana Carolina; Vicente, Creuza Rachel; Ferreira, Lucas Mendes; Fux, Blima; et al. "Atlantic Forest Malaria: A Review of More than 20 Years of Epidemiological Investigation". Microorganisms 9 1 (2021): 132. http://dx.doi.org/10.3390/microorganisms9010132.
    Open access • Published
  8. Cláudia Conceição, MD, PhD; Medeiros, MM; Nélia Pereira, MSc; Luzia Gonçalves, PhD; Abílio Antunes; Ellen Blondé; Rosa Teodósio, MD; Carlos Araújo, MD; Filomena Pereira, MD, PhD. "Health Problems During and After Travel: A Prospective Observational Study in a Travel Clinic in Portugal". Acta Médica Portuguesa 34 (2021): https://doi.org/10.20344/amp.14098.
    Published
  9. Cabral, Fernanda J; Vianna, Luciana G; Medeiros, Marcia M; Carlos, Bianca Cechetto; Martha, Rosimeire D; Silva, Nadia Maria; Silva, Luiz Hildebrando P da; Stabeli, Rodrigo G; Wunderlich, Gerhard. "Immunoproteomics of Plasmodium falciparum-infected red blood cell membrane fractions". Memórias do Instituto Oswaldo Cruz 112 12 (2017): 850-856. http://dx.doi.org/10.1590/0074-02760170041.
    Open access • Published • 10.1590/0074-02760170041
  10. Macedo-Silva, Tatiane; Araujo, Rosana Beatriz Duque; Meissner, Kamila Anna; Fotoran, Wesley Luzetti; Medeiros, Márcia Melo; de Azevedo, Mauro Ferreira; Wunderlich, Gerhard. "Knockdown of the Plasmodium falciparum SURFIN4.1 antigen leads to an increase of its cognate transcript". PLOS ONE 12 8 (2017): e0183129. http://dx.doi.org/10.1371/journal.pone.0183129.
    Open access • Published • 10.1371/journal.pone.0183129
  11. Lanaspa, Miguel; Bassat, Quique; Medeiros, Marcia Melo; Muñoz-Almagro, Camen. "Respiratory microbiota and lower respiratory tract disease". Expert Review of Anti-infective Therapy 15 7 (2017): 703-711. http://dx.doi.org/10.1080/14787210.2017.1349609.
    Open access • Published • 10.1080/14787210.2017.1349609
  12. Fotoran, Wesley L.; Santangelo, Rachele M.; Medeiros, Márcia M.; Colhone, Marcelle; Ciancaglini, Pietro; Barboza, Renato; Marinho, Claudio Romero Farias; Stábeli, Rodrigo Guerino; Wunderlich, Gerhard. "Liposomes loaded with P. falciparum merozoite-derived proteins are highly immunogenic and produce invasion-inhibiting and anti-toxin antibodies". Journal of Controlled Release 217 (2015): 121-127. http://dx.doi.org/10.1016/j.jconrel.2015.08.045.
    Published • 10.1016/j.jconrel.2015.08.045
  13. Fratus, Alessandra Sampaio Bassi; Cabral, Fernanda Janku; Fotoran, Wesley Luzetti; Medeiros, Márcia Melo; Carlos, Bianca Cechetto; Martha, Rosimeire dalla; Silva, Luiz Hildebrando Pereira da; et al. "Antibody recognition of Plasmodium falciparum infected red blood cells by symptomatic and asymptomatic individuals in the Brazilian Amazon". Memórias do Instituto Oswaldo Cruz 109 5 (2014): 598-601. http://dx.doi.org/10.1590/0074-0276140027.
    Open access • Published • 10.1590/0074-0276140027
  14. Medeiros, M.M.; Fotoran, W.L.; dalla Martha, R.C.; Katsuragawa, T.H.; Pereira da Silva, L.H.; Wunderlich, G.. "Natural antibody response to Plasmodium falciparum merozoite antigens MSP5, MSP9 and EBA175 is associated to clinical protection in the Brazilian Amazon". BMC Infectious Diseases 13 608 (2013): https://doi.org/10.1186/1471-2334-13-608.
    Open access • Published • 10.1186/1471-2334-13-608
  15. Medeiros, Márcia M.; Silva, Henrique B. da; Reis, Aramys S.; Barboza, Renato; Thompson, Joanne; Lima, Maria Regina D'Império; Marinho, Cláudio R. F.; Tadokoro, Carlos E.. "Liver Accumulation of Plasmodium chabaudi-Infected Red Blood Cells and Modulation of Regulatory T Cell and Dendritic Cell Responses". PLoS ONE 8 11 (2013): e81409. http://dx.doi.org/10.1371/journal.pone.0081409.
    Open access • Published • 10.1371/journal.pone.0081409
  16. Mariuba, Luis Andre; Orlandi, Patricia Puccinelli; Medeiros, Márcia; Holanda, Rudson; Grava, Andrea; Nogueira, Paulo Afonso. "Improving the production of the denatured recombinant N-terminal domain of rhoptry-associated protein 2 from a Plasmodium falciparum target in the pathology of anemia in falciparum malaria". Memórias do Instituto Oswaldo Cruz 103 6 (2008): 522-527. http://dx.doi.org/10.1590/s0074-02762008000600002.
    Open access • 10.1590/s0074-02762008000600002
Preprint
  1. Essoh, Anyse Pereira; Cassiano, Gustavo Capatti; Mandim, Filipa; Gomes, Isildo; Moura, Mónica; Medeiros, Márcia Melo; Cravo, Pedro; Romeiras, Maria Manuel. "Studies on the in vitro antiplasmodial activity of endemic and native plants from Cabo Verde". 2022. http://dx.doi.org/10.21203/rs.3.rs-1881844/v1.
  2. Buery, J.C.; Duarte, A.M.R.C.; Alencar, F.E.C.; Furieri, C.; Mendes, S.L.; Loss, A.C.; Vicente, C.R.; et al. "Detection of Plasmodium vivax in a liver sample of a howler-monkey: one evidence more in favour of the identity between Plasmodium simium and P. vivax". 2020. http://dx.doi.org/10.1101/2020.09.06.279869.
Thesis / Dissertation
  1. Medeiros, Márcia Melo. "Perfil da resposta imune humoral de pacientes sintomáticos e assintomáticos para malária falciparum, da Amazônia Ocidental Brasileira, contra antígenos polimórficos exportados para a superfície da hemácia infectada e antígenos exportados para a superfície da hemácia infectada e antígenos expressos no merozoíto.". PhD, Universidade de São Paulo - Instituto de Ciências Biomédicas, 2011. http://dx.doi.org/10.11606/t.42.2011.tde-21032012-144526.
    10.11606/t.42.2011.tde-21032012-144526
Working paper
  1. Julyana Cerqueira Buery; Ana Maria Ribeiro de Castro Duarte; Filomena Euridice Carvalho de Alencar; C. Furieri; S.L. Mendes; A.C. Loss; C.R. Vicente; et al. 2020. "Detection of Plasmodium vivax in a liver sample of a howler-monkey: one evidence more in favour of the identity between Plasmodium simium and P. vivax". https://novaresearch.unl.pt/en/publications/fd6b95ad-64a6-4cf7-83b4-8b95d30eebdc.
    10.1101/2020.09.06.279869
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/10/21 Oral poliomyelitis vaccine (OPV) boost drives changes in gut and upper respiratory microbiomes of infants. IV International Conference NOVAhealth Chronic Disease and Infection - Microbiota and Health
NOVA Saúde Chronic Disease and Infection Group (Portugal)
2018/07/04 HEALTH PROBLEMS DURING AND AFTER TRAVEL: A STUDY IN TRAVELERS ATTENDING AT THE IHMT'S TRAVEL CLINIC Encontro CIÊNCIA 2018
Ministério da Ciência, Tecnologia e Ensino Superior, Portugal (Lisboa, Portugal)
2011/09/19 "PLASMODIUM FALCIPARUM MEROZOITE ANTIGENS ASSOCIATED TO PROTECTION FROM NATURALLY ACQUIRED IMMUNE RESPONSE IN THE BRAZILIAN AMAZON" XXVII Annual Meeting of the Brazilian Society of Protozoology/ XXXVIII Annual Meeting on basic research in Chagas´Disease
Brazilian Society of Protozoology (SBPZ) (Foz do Iguaçu, Brazil)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/02/14 - Current Epidemiological analysis of sleeping sickness in Guinea-Bissau using an inhibition enzyme-linked immunosorbent assay - iELISA
Supervisor of Silvia Pires
 Master in Tropical Health (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2023/09/01 - Current Rapid detection of Single Nucleotide Polymorphisms (SNPs) associated with drug resistance in malaria parasites using isothermal amplification approach
Supervisor of Mariana de Andrade Ramos Pinto
 Master in Medical Parasitology (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - Current Infeções maláricas de baixa-densidade: importantes para a perpetuação da malária na Guiné-Bissau? Low-density infections: important for sustaining malaria in Guinea-Bissau?
Supervisor of Ronise Eneide Almeida Silva Gomes da Silva
 PhD in Global Health and Tropical Diseases (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/03/01 - 2022/06/01 Eritrócitos infetados com Plasmodium falciparum tratados e não tratados com o intermediário glicolítico sintético 2,3-difosfoglicerato (2,3-DPG): análise do perfil metabólico da célula hospedeira e do parasita.
Supervisor of Suelma de Jesus Oliveira Maciel
 Master in Biomedical Sciences (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/10/01 - 2021/06/30 Protective effect of red blood cell pyruvate kinase deficiency against malaria: is there a role for the host cell membrane?
Co-supervisor of Maria Duarte de Carvalho
Master in Medical Parasitology (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/01/13 - 2020/05/31 Glycolysis inside Plasmodium falciparum-infected erythrocyte - metabolomic profile of the erythrocyte and parasite
Supervisor of Ana Filipa Correia
 Project in Cell and Molecular Biology (PBCM) (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/09/01 - Current Journal clubs for postdocs and PhD students. Once a month, each person presents a scientific article for discussion, or the latest results of the thesis defence (PhD students), or their current or planned scientific project. (2017/09/01)
Meeting (President of the Organising Committee)
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2003/04/01 - 2003/12/31 Sports activities - walking - involving patients with Diabetes and Systemic Arterial Hypertension attended at the Public Center of Primary Health Care. (2003/04 - 2003/10)
Other (Co-organisor)
 Public Center of Primary Health Care of Campos Belos de Goiás - Goiás - Brasil, Brazil
1999/12/01 - 2000/08/01 Sports activities - walking - involving patients with Diabetes and Systemic Arterial Hypertension attended at the Public Center of Primary Health Care. (1999/12/01 - 2000/08/01)
Other (Co-organisor)
 Public center of Primary Health Care of Sobral - Ceará - Brazil, Brazil

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/01/23 - Current "Educational Thursdays": monthly sessions, generally on Thursdays, for academic community of IHMT NOVA to improve teaching and learning processes. The first session was about coaching methodologies in the guidance of 2nd and 3rd cycle dissertations.
Seminar
 Educational Thursdays
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2023/05/10 - 2023/05/10 Atttended the 4th Virtual Conference on and Malaria Immunology and Elimination (MIE-2023) on 10 May 2023.
Conference
 Malaria Immunology and Elimination
USG United Scientific Group, United States

Sociedade Portuguesa de Medicina do Viajante, Portugal
2021/11/08 - 2021/11/08 Attended the annual meeting of the Portuguese Society of Travel Medicine, which was held partly virtually due to the COVID-19 pandemic.
Meeting
 "Back to travel in times of COVID-19"
Sociedade Portuguesa de Medicina do Viajante, Portugal
2021/06/07 - 2021/06/09 Attended the Genomic Epidemiology of Malaria 2021 conference, which was entirely virtual due to the COVID-19 pandemic, with all participants' registration costs covered by the Bill and Melinda Gates Foundation.
Conference
 Genomic Epidemiology of Malaria 2021
Wellcome Connecting Science, United Kingdom
2019/11/21 - 2019/11/21 Attendance the Global Health and Tropical Medicine (GHTM) Special Session "Third GHTM Antimicrobial Resistance Awareness Day"
Seminar
 Third GHTM Antimicrobial Resistance Awareness Day
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/04/05 - 2019/04/05 Attendance the seminar "Deciphering Tick-Parasite Interactions Towards Human And Animal Health Improvement" organized under the project: PTDC/CVT/29073/2017 "Exploring the tick-host interactome: on the path to vaccine development"
Seminar
 "Deciphering Tick-Parasite Interactions Towards Human And Animal Health Improvement"
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017/12/14 - 2017/12/15 Attendance the workshop on the "History of Tropical Medicine"
Workshop
 History of Tropical Medicine
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017/12/12 - 2017/12/12 Attendance the scientific internal meeting "8as Jornadas Científicas do IHMT", in which NOVAIHMT PhD students of last cycles present yours final results. An invited speaker always gives the close session. In that year, Prof. Charles Stephen Mgone, President of the Scientific and Technical Advisory Committee of TDR and Vice-President of Hubert Kariuki Memorial University, Tanzania, gave the conference: "The Critical Transition: From Training to Practice".
Meeting
 8as Jornadas Científicas do IHMT
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017/10/30 - 2017/10/31 Attendance the workshop "Malaria transmission: current challenges and new tools in the elimination context"
Workshop
 Malaria transmission: current challenges and new tools in the elimination context
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017/06/05 - 2017/06/06 Attendance the course "Developing Supervisory Skills" (28 hours of work) at The NOVA Doctoral School, which aimed at providing additional training to supervisors, enhancing their personal and professional development and contributing to an inspiring work environment.
Other
 "Developing Supervisory Skills" course
Universidade Nova de Lisboa NOVA Doctoral School, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/06/27 Evaluation of the emergence of molecular markers of resistance to artemether-lumefantrine in Plasmodium falciparum from patients with uncomplicated malaria in Guinea-Bissau
President of the jury
 Sam Lourenço Mendes (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2015/10/19 "Avaliação da eficácia da vacina contra malária placentária em modelo experimental" - Evaluation of the efficacy of a vaccine against placental malaria in a experimental model"
(Thesis) Main arguer
 Sónia Ferreira Cunha (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023/07/12 - Current International Journal of Molecular Sciences (1422-0067) Multidisciplinary Digital Publishing Institute

Association member

Society Organization name Role
2022/12/15 - Current Sociedade Portuguesa de Medicina do Viajante - Portuguese Society of Travelers' Medicine Member
2017/01/12 - Current Portuguese Medical Association - Ordem dos Médicos de Portugal Associate member with professional card number 63227.
1999 - Current CREMESP - Regional Council of Medicine of the State of São Paulo Associate member with professional card number 100111. Current situation of inactivity, as I have not been living in Brazil.

Committee member

Activity description
Role 		Institution / Organization
2023/06 - Current Member representing IHMT NOVA in the Tourism and Hospitality Executive Committee of the NOVA University of Lisbon. The objective of this committee is improving, training and adding value to one of Portugal's most important economic sectors. As a medical doctor and scientist with experience of working in tropical areas, and with recent training and practice in travellers' medicine, I have contributed to the fundamental role that NOVA IHMT plays with regard to the issue of health in tourism activities.
Member
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Conference scientific committee

Conference name Conference host
2023/04/18 - 2023/04/21 6th National Conference on Tropical Medicine - Tropical Medicine and Sustainable Development Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical

Consulting

Activity description Institution / Organization
2019 - 2019/06/25 Reviewer of the article: "How worthwhile is methylene blue as a treatment of malaria?" (doi: 10.1080/14787210.2019.1634545 reported in "Expert Review of Anti-infective Therapy" (ISSN: 1478-7210 (Print) 1744-8336 (Online) Journal homepage: https://www.tandfonline.com/loi/ierz20).
2009/12/01 - 2010/10/05 Reviewer of the article titled " Directing pathogen-derived proteins to cells responsible for the immune response activation" (doi: 10.7594/revbio.6b.03) reported in Revista da Biologia (Rev. Biol., ISSN 1984-5154, DOI 10.7594/revbio) The University of São Paulo - Institute of Biosciences, Brazil

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/09/01 - Current Coordinator of the Viral Infections Curricular Unit of the Master's Degree in Tropical Health, Tropical Clinical Teaching and Research Unit. As well as coordinating the course, I teach classes on the epidemiology, clinical aspects, pathophysiology, treatment and prevention of influenza, measles, poliomyelitis and rabies, and supervise students in the seminars they present. Master in Tropical Health (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2022/06 - Current Practical classes on travel medicine for physicians, as part of the specialization course in Travel Medicine. Objectives: The course aims to impart knowledge about the prevention and treatment of travel-related diseases and risks. At the end, participants should be able to: Recognize the importance of travel medicine and recognize that each traveler and each region has its own specificities; Know the associated risk factors and how to overcome them; Know the sources of information available on travel medicine and know how to use them. Specialist in Travel Medicine (Especialização pós-licenciatura) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2018/03 - Current Theoretical class on "Immune response to malaria infection in endemic areas: from symptomatic infections to the lack of sterile immunity" for Master students of Master in Tropical Health program. Master in Tropical Health (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017/11 - Current Theoretical and practical classes on "Humoral Immunity" for students of Master on Biomedical Sciences, Course Unit "Immunology". The successive events involved in the ontogeny of B lymphocytes, development of the B cell receptor and at the primary activation of B cells are evidenced. Also, details of the types of immunoglobulins and their respective functions are provided, together with possible applications of specific antibodies in diagnostic tests, such as Immunoblotting, ELISA and Immunofluorescence. Master on Biomedical Sciences (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2010/06 - 2010/12 Laboratorial practice and theoretical teaching of Parasitology for undergraduate students of the University of São Paulo Faculty of Dental Medicine. Parasitolgy for Dental Medicine (Licenciatura) The University of São Paulo - Insitute of Biomedical Sciences, Brazil

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023 - Current Member of the interview team that selected the candidates for the Master's Degree in Tropical Health 2023/2024, offered by the Clinica Tropical Teaching and Research Unit, IHMT NOVA.
Evaluator
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2021/03/18 - Current Evaluation of projects in the field of Parasitology, which were submitted to the AIMS Meeting, Faculty of Medicine, University of Lisbon. AIMS Meeting [Annual International (bio)Medical Students Meeting] is the largest European Biomedical Conference organized by medical students from all years. It is essentially advocated by the Faculty of Medicine of the Lisbon Students' Local Committee and highlights the importance of medical education for all students of health sciences through a diverse approach.
Evaluator
 Universidade de Lisboa Faculdade de Medicina, Portugal

Students' Association of the Faculty of Medicine- University of Lisbon - AEFML, Portugal

Mentoring / Tutoring

Topic Student name
2023/07/24 - 2023/07/28 Ciência Viva - Science Holidays for Young People at GHTM-IHMTNOVA Cristiana Luo and Lucas Lehnert
2022/08/01 - 2022/08/12 Ciência Viva - Science Holidays for Young People at GHTM-IHMTNOVA Maria Gomes and Gustavo Santos
2019/07/22 - 2019/07/30 "Ciência Viva" at the laboratory at IHMTNOVA: "Fever, chills and body aches? Is it malaria? How to find the hidden parasite!" Beatriz Vaz Franscisco and Rita S.A. Lourenço
2014/01/06 - 2014/07/18 "DMXAA: a possible adjuvant in antimalarial vaccination strategies?" Melisssa Newling (s1860011)
2013/06/01 - 2013/08/31 "Blood stage suppression on liver stage immunity" Michel da Veiga

Other jury / evaluation

Activity description Institution / Organization
2019/11/18 - Current Member of the selection committee for the call for applications for a Master's Research Fellowship in the project: "When the host cell is no longer so welcoming... A drop in energy or an increase in toxicity? A drop in energy or an increase in toxicity? (PlasmDPG)", funded by national resources through the Foundation for Science and Technology, under the reference PTDC/BIA-CEL/28456/2017. Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Scientific expedition

Activity description Institution / Organization
2018/08/30 - 2018/12/20 Collection, processing and storage of faecal and nasopharyngeal biological samples, from 4 - 8 months older infants from Guinea-Bissau. Spervision and training in the field of a nurse and field worker of the Bandim Health Project. Elaboration of SOPs (collection, processing and storage of microbiome contents, DNA extraction to NGS), under the MicroOPV project- assesing the effect of oral poliomyelitis vaccine on gut and respiratory microbiomes of Bissau-Guinean infants, which were integrated in the Biotropical resources, the GHTM/IHMT-NOVA biobank. Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal

Bandim Health Project, Guinea-Bissau

Statens Serum Institute, Denmark
2004/08/01 - 2004/09/01 Collection of peripheral venous blood and bone marrow from Plasmodium falciparum-infected patients living in Western Brazilian Amazon, under a field work organized by IPEPATRO, in collaboration with Université de la Méditerranée. Results highlighting the hole of P. falciparum antigen RSP-2 on triggering anaemia in malaria, boosted studies on this potential therapeutic target. Antibody recognition of the recombinant N-terminal domain of RSP-2 by plasmas of anaemic P.falciparum infected patients were reported in doi.org/10.1590/S0074-02762008000600002 Fundação Oswaldo Cruz - Rondônia, Brazil

Instituto de Pesquisas em Patologias Tropicais de Rondônia - IPEPATRO, Brazil

Université de la Méditérranée (Aix-Marseille II), France
Distinctions

Title

2004 Specialist in General and Internal Medicine
Associação Médica Brasileira, Brazil

Sociedade Brasileira de Clínica Médica, Brazil

Other distinction

2013 Ability to carry out research on experimental animal models as investigator - FELASA category B
Direção Geral de Alimentação e Veterinária, Portugal