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Karina Xavier is am Principal Investigator at Instituto Gulbenkian de Ciência in Portugal since 2006. The main focus of her research is inter-species cell-cell communication in bacteria and its role in beneficial and hostile interactions with the host. K. Xavier received her PhD from ITQB - Nova, Lisbon in 1999 for her work on carbohydrate metabolism in Archaea. She started working on bacterial quorum sensing in her postdoc at Princeton University with Professor Bonnie Bassler. At Princeton, she showed that the quorum sensing signal autoinducer-2 (AI-2) can foster interspecies communication in bacteria. As an independent PI of several European and National funded grants, she has established an independent research group and went on to discover novel mechanisms involved in quorum sensing signal transduction networks and metabolism. In 2012, she was awarded an HHMI International Early Career Award. Via the HHMI funded project, her group established a setup to manipulate inter-species quorum sensing in the mammalian gut. As a result of this work, her group showed that it is possible to influence the species composition of the microbiota by manipulating interspecies quorum sensing directly in the mouse gut and that AI-2 increase can ameliorate the effect of antibiotic-induced dysbiosis. Currently, K. Xavier's group is studying mechanisms involved in the recovery of microbiota imbalances and has identified a keystone microbiota member that is sufficient for restoring colonization resistance against Enterobacteriaceae post-antibiotic treatment. K. Xavier most recent work highlights the importance of the gut metabolic environment shaped by the microbiota and diet in driving ecology and evolution of this ecosystem. In 2019 she was elected member of the European Academy for Microbiology, EMBO member in 2021, and member of the American Academy for Microbiology in 2022.
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Identification

Personal identification

Full name
Karina Xavier

Citation names

  • Xavier, Karina
  • Karina B. Xavier

Author identifiers

Ciência ID
641F-7328-B863
ORCID iD
0000-0001-5210-1434

Email addresses

  • kxavier@igc.gulbenkian.pt (Professional)

Telephones

Telephone
  • 214464655 (Professional)

Addresses

  • Instituto Gulbenkian de Ciência. Apartado 14, P-2781-901, Oeiras, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
1999
Concluded
 Bioquímica (Doutoramento)
Major in Sem especialidade
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Carbohydrate Metabolism in Hypperthermophylic Microorganisms" (THESIS/DISSERTATION)
1994
Concluded
 Biochemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Studies of Microbial Metabolism using Non-Invasive in vivo NMR Techniques." (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2017 - Current Coordinating Researcher (Research) Fundação Calouste Gulbenkian, Portugal
Instituto Gulbenkian de Ciência, Portugal
2012 - 2017 Researcher (Research) Howard Hughes Medical Institute, United States
2006 - 2017 Principal Investigator (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2006 - 2014 Auxiliary Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2003 - 2006 Researcher (Research) Princeton University, United States
2000 - 2003 Postdoc (Research) Princeton University, United States
Projects

Grant

Designation Funders
2022/11/01 - 2025/12/31 Advanced Training Course in Host-Microbe Symbiosis
GBMF11550
GBMF11550
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Gordon and Betty Moore Foundation
Ongoing
2021/03 - 2024/08/31 Manipulating Quorum Sensing to promote Muribaculum resilience in gut microbiota dysbiosis
PTDC/BIA-MIC/6990/2020
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2022/06/28 Deciphering the mechanisms of interspecies bacterial communication towards the manipulation of the mammalian gut microbiota
PTDC/BIA-BQM/29668/2017
Researcher
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10 - 2022/02 Identification of novel quorum sensing signals in the mammalian gut microbiota
PTDC/BIA-MIC/30487/2017
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/05 - 2019/04 Role of the microbiota in the defense against multidrug-resistant Enterobacteriaceae
Infect-ERA/0004/2015
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 ERAMET
Concluded
2016/01 - 2018/12 The role of inter-species quorum sensing in the recovery from antibiotic-induced imbalances of gut microbiota
Provided by PTCRIS: 142819
grant.Provided by PTCRIS: 142819
PTDC/BIA-MIC/4188/2014
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/02 - 2017/01 Inter-species cell-cell signalling: its role in bacteria consortia
HHMI 55007436
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Howard Hughes Medical Institute
Concluded
2013/06 - 2016/05 NMR Net - National Facility for Nuclear Magnetic Resonance: from Molecular Structure and Dynamics to Protein Function, Cell Physiology, and Metabolomics
grant.Provided by PTCRIS: 127013
RECI/BBB-BQB/0230/2012
Other
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/03 - 2016/02 Host microbe interaction at Instituto Gulbenkian de Ciência
grant.Provided by PTCRIS: 124215
RECI/IMI-IMU/0038/2012
Other
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/03 - 2015/02 Adaptation of commensal bacteria to the mammalian gut
grant.Provided by PTCRIS: 118075
PTDC/BIA-EVF/118075/2010
Other
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/03 - 2014/04 Studies on the structure/activity relationship of AI-2, a bacterial signalling molecule for inter-species communication.
grant.Provided by PTCRIS: 113880
Other
Stichting Weten
2010/02 - 2013/02 Inhibition of bacterial plant virulence by interference with interspecies cell-cell communication.
grant.Provided by PTCRIS: 101585
PTDC/BIA-BCM/101585/2008
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/10 - 2010/09 Identification and characterization of quorum sensing systems involved in bacterial inter-species communication
grant.Provided by PTCRIS: 73676
PTDC/BIA-BCM/73676/2006
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/10 - 2009/09 Quorum Sensing in Escherichia coli
grant.Provided by PTCRIS: 82010
PPCDT/DG/BIA/82010/2006
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2006/03 - 2008/02 Inter-species cell-cell signalling in bacteria
031108
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Concluded
2006 - 2007 Portugal-EUA: Research Network Grants 2006
Proj. 600-10/2006
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação Luso-Americana

National Science Foundation Directorate for Biological Sciences
Concluded
Outputs

Publications

Book chapter
  1. Taga, M.E.; Xavier, K.B.. "Methods for analysis of bacterial autoinducer-2 production". In Current Protocols in Microbiology, 1C.1.1-1C.1.15. Wiley, 2011.
    10.1002/9780471729259.mc01c01s23
Journal article
  1. Julia C. van Kessel; Wai-Leung Ng; Karina B. Xavier. "The Queen of Quorum Sensing: Scientist, Bacterial Linguist, Professor, Mentor". Israel Journal of Chemistry (2023): https://doi.org/10.1002/ijch.202300080.
    10.1002/ijch.202300080
  2. Rita A. Oliveira; Vitor Cabral; Inês Torcato; Karina B. Xavier. "Deciphering the quorum-sensing lexicon of the gut microbiota". Cell Host & Microbe (2023): https://doi.org/10.1016/j.chom.2023.03.015.
    10.1016/j.chom.2023.03.015
  3. Rodrigues, M.V.; Kis, P.; Xavier, K.B.; Ventura, M.R.. "Synthesis and potential of Autoinducer-2 and analogs to manipulate inter-species Quorum Sensing". Israel Journal of Chemistry (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85146527315&partnerID=MN8TOARS.
    10.1002/ijch.202200091
  4. Dapa, T.; Wong, D.P.; Vasquez, K.S.; Xavier, K.B.; Huang, K.C.; Good, B.H.. "Within-host evolution of the gut microbiome". Current Opinion in Microbiology 71 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85145651858&partnerID=MN8TOARS.
    10.1016/j.mib.2022.102258
  5. Dapa, Tanja; Ramiro, Ricardo Serotte; Pedro, Miguel Filipe; Gordo, Isabel; Xavier, Karina Bivar. Corresponding author: Xavier, Karina Bivar. "Diet leaves a genetic signature in a keystone member of the gut microbiota". Cell Host & Microbe 30 2 (2022): 183-199.e10. http://dx.doi.org/10.1016/j.chom.2022.01.002.
    Published • 10.1016/j.chom.2022.01.002
  6. Djukovic, A.; Garzón, M.J.; Canlet, C.; Cabral, V.; Lalaoui, R.; García-Garcerá, M.; Rechenberger, J.; et al. "Lactobacillus supports Clostridiales to restrict gut colonization by multidrug-resistant Enterobacteriaceae". Nature Communications 13 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85138457852&partnerID=MN8TOARS.
    10.1038/s41467-022-33313-w
  7. Vasquez, Kimberly S.; Willis, Lisa; Cira, Nate J.; Ng, Katharine M.; Pedro, Miguel F.; Aranda-Díaz, Andrés; Rajendram, Manohary; et al. "Quantifying rapid bacterial evolution and transmission within the mouse intestine". Cell Host & Microbe 29 9 (2021): 1454-1468.e4. http://dx.doi.org/10.1016/j.chom.2021.08.003.
    10.1016/j.chom.2021.08.003
  8. Oliveira, Rita A.; Cabral, Vitor; Xavier, Karina B.. Corresponding author: Xavier, Karina B.. "Microbiome diet interactions drive antibiotic efficacy". Nature Microbiology 6 7 (2021): 824-825. http://dx.doi.org/10.1038/s41564-021-00926-8.
    10.1038/s41564-021-00926-8
  9. Ascenso, Osvaldo S.; Carrau, Gonzalo; Xavier, Karina B.; Ventura, M. Rita; Maycock, Christopher D.. "An Efficient Synthesis of Optically Active [4-13C] Labelled Quorum Sensing Signal Autoinducer-2". Molecules 26 2 (2021): 369. http://dx.doi.org/10.3390/molecules26020369.
    10.3390/molecules26020369
  10. Filipe J. D. Vieira; Pol Nadal-Jimenez; Luis Teixeira; Karina B. Xavier; Karina B. Xavier; Christopher M. Waters; Edward G. Ruby. Corresponding author: Karina B. Xavier. "Erwinia carotovora Quorum Sensing System Regulates Host-Specific Virulence Factors and Development Delay in Drosophila melanogaster". mBio 11 3 (2020): e01292--20. https://mbio.asm.org/content/mbio/11/3/e01292-20.full.pdf.
    Open access • Published • 10.1128/mBio.01292-20
  11. João Barroso-Batista; Miguel F. Pedro; Joana Sales-Dias; Catarina J.G. Pinto; Jessica A. Thompson; Helena Pereira; Jocelyne Demengeot; et al. Corresponding author: Karina B. Xavier. "Specific Eco-evolutionary Contexts in the Mouse Gut Reveal Escherichia coli Metabolic Versatility". Current Biology 30 6 (2020): 1049-1062.e7. https://doi.org/10.1016/j.cub.2020.01.050.
    10.1016/j.cub.2020.01.050
  12. Oliveira, Rita A.; Ng, Katharine M.; Correia, Margarida B.; Cabral, Vitor; Shi, Handuo; Sonnenburg, Justin L.; Huang, Kerwyn Casey; Xavier, Karina B.. Corresponding author: Xavier, Karina B.. "Klebsiella michiganensis transmission enhances resistance to Enterobacteriaceae gut invasion by nutrition competition". Nature Microbiology 5 4 (2020): 630-641. http://dx.doi.org/10.1038/s41564-019-0658-4.
    10.1038/s41564-019-0658-4
  13. Djukovic, Ana; González-Barberá, Eva M.; Sanz, Jaime; Artacho, Alejandro; Peñaranda, Iván; Herrera, Beatriz; Garzón, María José; et al. "High Heterogeneity of Multidrug-Resistant Enterobacteriaceae Fecal Levels in Hospitalized Patients Is Partially Driven by Intravenous ß-Lactams". Antimicrobial Agents and Chemotherapy 64 2 (2019): e01415-e01419. http://dx.doi.org/10.1128/aac.01415-19.
    10.1128/aac.01415-19
  14. Ng, Katharine Michelle; Aranda-Díaz, Andrés; Tropini, Carolina; Frankel, Matthew Ryan; Van Treuren, William; O’Laughlin, Colleen T.; Merrill, Bryan Douglas; et al. "Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs". Cell Host & Microbe 26 5 (2019): 650-665.e4. http://dx.doi.org/10.1016/j.chom.2019.10.011.
    10.1016/j.chom.2019.10.011
  15. Miranda, Vanessa; Torcato, Inês M.; Xavier, Karina B.; Ventura, M. Rita. "Synthesis of d-desthiobiotin-AI-2 as a novel chemical probe for autoinducer-2 quorum sensing receptors". Bioorganic Chemistry 92 (2019): 103200. http://dx.doi.org/10.1016/j.bioorg.2019.103200.
    10.1016/j.bioorg.2019.103200
  16. Lalaoui, Rym; Djukovic, Ana; Bakour, Sofiane; Sanz, Jaime; Gonzalez-Barbera, Eva M.; Salavert, Miguel; López-Hontangas, Jose Luis; et al. "Detection of plasmid-mediated colistin resistance, mcr-1 gene, in Escherichia coli isolated from high-risk patients with acute leukemia in Spain". Journal of Infection and Chemotherapy 25 8 (2019): 605-609. http://dx.doi.org/10.1016/j.jiac.2019.03.007.
    10.1016/j.jiac.2019.03.007
  17. Ascenso, Osvaldo S.; Torcato, Inês M.; Miguel, Ana Sofia; Marques, João C.; Xavier, Karina B.; Ventura, M. Rita; Maycock, Christopher D.. "Synthesis and biological activity of a potent optically pure autoinducer-2 quorum sensing agonist". Bioorganic Chemistry 85 (2019): 75-81. http://dx.doi.org/10.1016/j.bioorg.2018.12.022.
    10.1016/j.bioorg.2018.12.022
  18. Torcato, Inês M.; Kasal, Meghann R.; Brito, Patrícia H.; Miller, Stephen T.; Xavier, Karina B.. "Identification of novel autoinducer-2 receptors in Clostridia reveals plasticity in the binding site of the LsrB receptor family". Journal of Biological Chemistry 294 12 (2019): 4450-4463. http://dx.doi.org/10.1074/jbc.ra118.006938.
    10.1074/jbc.ra118.006938
  19. Rechenberger, Julia; Samaras, Patroklos; Jarzab, Anna; Behr, Juergen; Frejno, Martin; Djukovic, Ana; Sanz, Jaime; et al. "Challenges in Clinical Metaproteomics Highlighted by the Analysis of Acute Leukemia Patients with Gut Colonization by Multidrug-Resistant Enterobacteriaceae". Proteomes 7 1 (2019): 2. http://dx.doi.org/10.3390/proteomes7010002.
    10.3390/proteomes7010002
  20. Özkaya, Özhan; Balbontín, Roberto; Gordo, Isabel; Xavier, Karina B.. "Cheating on Cheaters Stabilizes Cooperation in Pseudomonas aeruginosa". Current Biology 28 13 (2018): 2070-2080. http://dx.doi.org/10.1016/j.cub.2018.04.093.
    10.1016/j.cub.2018.04.093
  21. Bivar Xavier, Karina. "Bacterial interspecies quorum sensing in the mammalian gut microbiota". Comptes Rendus Biologies 341 5 (2018): 297-299. http://dx.doi.org/10.1016/j.crvi.2018.03.006.
    10.1016/j.crvi.2018.03.006
  22. Cabral, Vitor; Xavier, Karina B.. "Bacterial Call to Arms for Warfare at the Infection Site". Cell Host & Microbe 23 3 (2018): 285-287. http://dx.doi.org/10.1016/j.chom.2018.02.009.
    10.1016/j.chom.2018.02.009
  23. Özkaya, Özhan; Xavier, Karina B.; Dionisio, Francisco; Balbontín, Roberto. "Maintenance of Microbial Cooperation Mediated by Public Goods in Single- and Multiple-Trait Scenarios". Journal of Bacteriology 199 22 (2017): e00297-17. http://dx.doi.org/10.1128/jb.00297-17.
    10.1128/jb.00297-17
  24. Valente, Rita S.; Nadal-Jimenez, Pol; Carvalho, André F. P.; Vieira, Filipe J. D.; Xavier, Karina B.. "Signal Integration in Quorum Sensing Enables Cross-Species Induction of Virulence in Pectobacterium wasabiae". mBio 8 3 (2017): e00398-17. http://dx.doi.org/10.1128/mbio.00398-17.
    10.1128/mbio.00398-17
  25. Lourenço, Marta; Ramiro, Ricardo S.; Güleresi, Daniela; Barroso-Batista, João; Xavier, Karina B.; Gordo, Isabel; Sousa, Ana. "A Mutational Hotspot and Strong Selection Contribute to the Order of Mutations Selected for during Escherichia coli Adaptation to the Gut". PLOS Genetics 12 11 (2016): e1006420. http://dx.doi.org/10.1371/journal.pgen.1006420.
    10.1371/journal.pgen.1006420
  26. Thompson, J.A.; Oliveira, R.A.; Xavier, K.B.. "Chemical conversations in the gut microbiota". Gut microbes 7 2 (2016): 163-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015632481&partnerID=MN8TOARS.
    10.1080/19490976.2016.1145374
  27. Valente, R.S.; Xavier, K.B.. "The Trk potassium transporter is required for RsmB-mediated activation of virulence in the phytopathogen Pectobacterium wasabiae". Journal of Bacteriology 198 2 (2016): 248-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953896746&partnerID=MN8TOARS.
    10.1128/JB.00569-15
  28. Thompson, J.A.; Oliveira, R.; Djukovic, A.; Ubeda, C.; Xavier, K.B.. "Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota". Cell Reports 10 11 (2015): 1861-1871. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925600482&partnerID=MN8TOARS.
    10.1016/j.celrep.2015.02.049
  29. Barroso-Batista, João; Sousa, Ana; Lourenço, Marta; Bergman, Marie-Louise; Sobral, Daniel; Demengeot, Jocelyne; Xavier, Karina B.; Gordo, Isabel. "The First Steps of Adaptation of Escherichia coli to the Gut Are Dominated by Soft Sweeps". PLoS Genetics 10 3 (2014): e1004182. http://dx.doi.org/10.1371/journal.pgen.1004182.
    10.1371/journal.pgen.1004182
  30. Thompson, J.A.; Oliveira, R.A.; Xavier, K.B.. "Can chatter between microbes prevent cholera?". Trends in Microbiology 22 12 (2014): 660-662. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922768886&partnerID=MN8TOARS.
    10.1016/j.tim.2014.10.006
  31. Marques, J.C.; Oh, I.K.; Ly, D.C.; Lamosa, P.; Ventura, M.R.; Miller, S.T.; Xavier, K.B.. "LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2". Proceedings of the National Academy of Sciences of the United States of America 111 39 (2014): 14235-14240. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907587733&partnerID=MN8TOARS.
    10.1073/pnas.1408691111
  32. Gordo, I.; Demengeot, J.; Xavier, K.. "Escherichia coli adaptation to the gut environment: A constant fight for survival". Future Microbiology 9 11 (2014): 1235-1238. http://www.scopus.com/inward/record.url?eid=2-s2.0-84914679700&partnerID=MN8TOARS.
    10.2217/fmb.14.86
  33. Pereira, C.S.; Thompson, J.A.; Xavier, K.B.. "AI-2-mediated signalling in bacteria". FEMS Microbiology Reviews 37 2 (2013): 156-181. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873315902&partnerID=MN8TOARS.
    10.1111/j.1574-6976.2012.00345.x
  34. Brito, P.H.; Rocha, E.P.C.; Xavier, K.B.; Gordo, I.. "Natural genome diversity of AI-2 quorum sensing in Escherichia coli: Conserved signal production but labile signal reception". Genome Biology and Evolution 5 1 (2013): 16-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876583216&partnerID=MN8TOARS.
    10.1093/gbe/evs122
  35. Jimenez, P.N.; Koch, G.; Thompson, J.A.; Xavier, K.B.; Cool, R.H.; Quax, W.J.. "The multiple signaling systems regulating virulence in Pseudomonas aeruginosa". Microbiology and Molecular Biology Reviews 76 1 (2012): 46-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860539275&partnerID=MN8TOARS.
    10.1128/MMBR.05007-11
  36. Rui, F.; Marques, J.C.; Miller, S.T.; Maycock, C.D.; Xavier, K.B.; Ventura, M.R.. "Stereochemical diversity of AI-2 analogs modulates quorum sensing in Vibrio harveyi and Escherichia coli". Bioorganic and Medicinal Chemistry 20 1 (2012): 249-256. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855192035&partnerID=MN8TOARS.
    10.1016/j.bmc.2011.11.007
  37. Pereira, C.S.; Santos, A.J.M.; Bejerano-Sagie, M.; Correia, P.B.; Marques, J.C.; Xavier, K.B.. "Phosphoenolpyruvate phosphotransferase system regulates detection and processing of the quorum sensing signal autoinducer-2". Molecular Microbiology 84 1 (2012): 93-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858861493&partnerID=MN8TOARS.
    10.1111/j.1365-2958.2012.08010.x
  38. Ascenso, O.S.; Marques, J.C.; Santos, A.R.; Xavier, K.B.; Rita Ventura, M.; Maycock, C.D.. "An efficient synthesis of the precursor of AI-2, the signalling molecule for inter-species quorum sensing". Bioorganic and Medicinal Chemistry 19 3 (2011): 1236-1241. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551471667&partnerID=MN8TOARS.
    10.1016/j.bmc.2010.12.036
  39. Marques, J.C.; Lamosa, P.; Russell, C.; Ventura, R.; Maycock, C.; Semmelhack, M.F.; Miller, S.T.; Xavier, K.B.. "Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): Characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein". Journal of Biological Chemistry 286 20 (2011): 18331-18343. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955945955&partnerID=MN8TOARS.
    10.1074/jbc.M111.230227
  40. Diaz, Z.; Xavier, K.B.; Miller, S.T.. "The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF". PLoS ONE 4 8 (2009): e6820. http://www.scopus.com/inward/record.url?eid=2-s2.0-69949092198&partnerID=MN8TOARS.
    10.1371/journal.pone.0006820
  41. Trindade, S.; Sousa, A.; Xavier, K.B.; Dionisio, F.; Ferreira, M.G.; Gordo, I.. "Positive epistasis drives the acquisition of multidrug resistance". PLoS Genetics 5 7 (2009): e1000578. http://www.scopus.com/inward/record.url?eid=2-s2.0-68249108837&partnerID=MN8TOARS.
    10.1371/journal.pgen.1000578
  42. Pereira, C.S.; De Regt, A.K.; Brito, P.H.; Miller, S.T.; Xavier, K.B.. "Identification of functional LsrB-like autoinducer-2 receptors". Journal of Bacteriology 191 22 (2009): 6975-6987. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350440286&partnerID=MN8TOARS.
    10.1128/JB.00976-09
  43. Pereira, C.S.; McAuley, J.R.; Taga, M.E.; Xavier, K.B.; Miller, S.T.. "Sinorhizobium meliloti, a bacterium lacking the autoinducer-2 (AI-2) synthase, responds to AI-2 supplied by other bacteria". Molecular Microbiology 70 5 (2008): 1223-1235. http://www.scopus.com/inward/record.url?eid=2-s2.0-55349147336&partnerID=MN8TOARS.
    10.1111/j.1365-2958.2008.06477.x
  44. Bejerano-Sagie, M.; Xavier, K.B.. "The role of small RNAs in quorum sensing". Current Opinion in Microbiology 10 2 (2007): 189-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247134625&partnerID=MN8TOARS.
    10.1016/j.mib.2007.03.009
  45. Xavier, K.B.; Miller, S.T.; Lu, W.; Kim, J.H.; Rabinowitz, J.; Pelczer, I.; Semmelhack, M.F.; Bassler, B.L.. "Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria". ACS Chemical Biology 2 2 (2007): 128-136. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847700090&partnerID=MN8TOARS.
    10.1021/cb600444h
  46. Xavier, K.B.; Bassler, B.L.. "Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli". Journal of Bacteriology 187 1 (2005): 238-248. http://www.scopus.com/inward/record.url?eid=2-s2.0-11144288181&partnerID=MN8TOARS.
    10.1128/JB.187.1.238-248.2005
  47. Xavier, K.B.; Bassler, B.L.. "Interference with AI-2-mediated bacterial cell-cell communication". Nature 437 7059 (2005): 750-753. http://www.scopus.com/inward/record.url?eid=2-s2.0-26944472857&partnerID=MN8TOARS.
    10.1038/nature03960
  48. Miller, S.T.; Xavier, K.B.; Campagna, S.R.; Taga, M.E.; Semmelhack, M.F.; Bassler, B.L.; Hughson, F.M.. "Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2". Molecular Cell 15 5 (2004): 677-687. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444332516&partnerID=MN8TOARS.
    10.1016/j.molcel.2004.07.020
  49. Xavier, K.B.; Bassler, B.L.. "LuxS quorum sensing: More than just a numbers game". Current Opinion in Microbiology 6 2 (2003): 191-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037676088&partnerID=MN8TOARS.
    10.1016/S1369-5274(03)00028-6
  50. Johnsen, U.; Selig, M.; Xavier, K.B.; Santos, H.; Schönheit, P.. "Different glycolytic pathways for glucose and fructose in the halophilic archaeon Halococcus saccharolyticus". Archives of Microbiology 175 1 (2001): 52-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035106495&partnerID=MN8TOARS.
    10.1007/s002030000237
  51. Xavier, K.B.; Da Costa, M.S.; Santos, H.. "Demonstration of a novel glycolytic pathway in the hyperthermophilic archaeon Thermococcus zilligii by 13C-labeling experiments and nuclear magnetic resonance analysis". Journal of Bacteriology 182 16 (2000): 4632-4636. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033905714&partnerID=MN8TOARS.
    10.1128/JB.182.16.4632-4636.2000
  52. Xavier, K.B.; Peist, R.; Kossmann, M.; Boos, W.; Santos, H.. "Maltose metabolism in the hyperthermophilic archaeon Thermococcus litoralis: Purification and characterization of key enzymes". Journal of Bacteriology 181 11 (1999): 3358-3367. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033003021&partnerID=MN8TOARS.
  53. Horlacher, R.; Xavier, K.B.; Santos, H.; Diruggiero, J.; Kossmann, M.; Boos, W.. "Archaeal binding protein-dependent ABC transporter: Molecular and biochemical analysis of the trehalose/maltose transport system of the hyperthermophilic archaeon Thermococcus litoralis". Journal of Bacteriology 180 3 (1998): 680-689. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031888811&partnerID=MN8TOARS.
  54. Selig, M.; Xavier, K.B.; Santos, H.; Schönheit, P.. "Comparative analysis of Embden-Meyerhof and Entner-Doudoroff glycolytic pathways in hyperthermophilic archaea and the bacterium Thermotoga". Archives of Microbiology 167 4 (1997): 217-232. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031002263&partnerID=MN8TOARS.
    10.1007/BF03356097
  55. Xavier, K.B.; Martins, L.O.; Peist, R.; Kossmann, M.; Boos, W.; Santos, H.. "High-affinity maltose/trehalose transport system in the hyperthermophilic archaeon Thermococcus litoralis". Journal of Bacteriology 178 16 (1996): 4773-4777. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029779716&partnerID=MN8TOARS.
    10.1128/jb.178.16.4773-4777.1996
  56. Xavier, K.B.; Kossmann, M.; Santos, H.; Boos, W.. "Kinetic analysis by in vivo 31P nuclear magnetic resonance of internal P(i) during the uptake of sn-glycerol-3-phosphate by the pho regulon- dependent Ugp system and the glp regulon-dependent GlpT system". Journal of Bacteriology 177 3 (1995): 699-704. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028952583&partnerID=MN8TOARS.
    10.1128/jb.177.3.699-704.1995
  57. Schäfer, T.; Xavier, K.B.; Santos, H.; Schönheit, P.. "Glucose fermentation to acetate and alanine in resting cell suspensions of Pyrococcus furiosus: Proposal of a novel glycolytic pathway based on13C labelling data and enzyme activities". FEMS Microbiology Letters 121 1 (1994): 107-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028234865&partnerID=MN8TOARS.
    10.1111/j.1574-6968.1994.tb07083.x
Preprint
  1. Vitor Cabral; Rita A. Oliveira; Margarida B. Correia; Miguel F. Pedro; Carles Ubeda; Karina B. Xavier. "Gut protectiveKlebsiellaspecies promotes microbiota recovery and pathobiont clearance while preventing inflammation". 2023. https://doi.org/10.1101/2023.11.14.566997.
    10.1101/2023.11.14.566997

Intellectual property

Patent
  1. Karina B. Xavier. 2005. "LsrB structure and AI-2 analogous". United States.
    Granted/Issued

Other

Other output
  1. Quorum sensing regulation in Erwinia carotovora affects development of Drosophila melanogaster infected larvae. bioRxiv. doi: https://doi.org/10.1101/2019.12.13.876318. 2019. Filipe J. D. Vieira; Pol Nadal-Jimenez; Luis Teixeira; Karina B. Xavier. https://doi.org/10.1101/2019.12.13.876318.
    10.1101/2019.12.13.876318
  2. Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet and Environmental Reservoirs. 2019. Ng, K.M.; Aranda-Diaz, A.; Tropini, C.; Frankel, M.R.; van Treuren, W.W.; O’Laughlin, C.; Merrill, B.D.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85113994599&partnerID=MN8TOARS.
    10.2139/ssrn.3325029
  3. Cheating on cheaters dramatically affects social interactions in Pseudomonas aeruginosa. bioRxiv. https://doi.org/10.1101/118240. 2017. Özhan Özkaya; Roberto Balbontín; Isabel Gordo; Karina B. Xavier. https://doi.org/10.1101/118240.
    10.1101/118240
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11 Keystone gut microbiota promoting pathobiont clearance by nutrition competition and microbiota recovering Biozentrum, University of Basel, Infection Biology, Departmental Seminar
University of Basel (Switzerland)
2023/07 Interspecies Interactions Shaping gut Microbiota Functions Gordon Research Conference on Adhesin and Signal Transduction
Gordon Research Conference (United States)
2022/11 Diet shapes evolution of a key member of the gut microbiota Seminar
Pasteur Institute (France)
2022/09 Social Interactions in gut Microbiota Communities. EMBO-FEBS Lecture Course - The new microbiology.
EMB-FEBS (Greece)
2022/04 Diet shapes evolution of a key member of the gut microbiota Departmental Seminar
Oxford University (United Kingdom)
2021/10/01 Nutrition competition in the intestinal microbiome International Conference “12 Topics in Rheumatology, 3rd Edition”.
NOVA Medical School | Universidade Nova de Lisboa (Lisbon, Portugal)
2019/07 Talking from the gut: Quorum Sensing in the gut microbiota Molecular advances in understanding bacterial communication.
Princeton University (United States)
2018/07 Bacterial Interspecies Quorum Sensing in the Mammalian Gut Microbiota Microbial Sciences Institute Seminar. Yale University
Yale University (United States)
2018/06 Talking from the gut: cell-cell communication in the gut microbiome Workshop: Physical Principles Governing the Organization of Microbial Communities
(Aspen, CO, United States)
2018/04 Bacterial Interspecies Quorum Sensing in the Mammalian Gut Microbiota CIIMAR
Universidade do Porto (Porto, Portugal)
2018/01 Bacterial Interspecies Quorum Sensing in the Mammalian Gut Microbiota
Bioengineering Department, Shriram Center, Stanford University (Standford, United States)
2018/01 Bacterial Interspecies Quorum Sensing in the Mammalian Gut Microbiota Gordon Research Conference on Sensing and Signaling: From Single Molecules to Host-Microbe Interactions
(Ventura, CA, United States)
2018 Inter-species Quorum sensing in the mammalian gut microbiota. VAAM-FG Summer School in Mechanisms of Gene Regulation.
(Tutzing, Germany)
2017/05 Bacterial Interspecies Quorum Sensing in the Mammalian Gut Microbiota iBiMED
Universidade de Aveiro (Aveiro, Portugal)
2017/03 Manipulation of Interspecies Quorum Sensing Signalling in the Mouse Gut Molecular Virology and Microbiology Seminar Series
Baylor College of Medicine (Texas, United States)
2017/03 Manipulation of the Interspecies Quorum Sensing Signal in Mouse Gut Gordon Research Conference on Multi-Drug Efflux Systems
(Galveston, TX, United States)
2017 Bacterial interspecies quorum sensing in the mammalian gut microbiota Symposium - Symbiosis and cohabitation
Institut de France, Académie des Sciences (Paris, France)
2016/07 Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota Gordon Research Conference on Microbial Stress Response
Mount Holyoke College South Hadley (Hadley, United States)
2016/06 Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota Gordon Research Conference on Bacterial Cell Surfaces
(Mount Snow, Vermont, United States)
2016/05 AI-2 and homeostasis of gut microbiota International Symposium at the College France on “Communication among Complex Microbial Populations and Their Host”
(Paris, France)
2015/09 Manipulation of bacterial interspecies Quorum Sensing in the mouse gut Max Planck Institute for Terrestrial Microbiology
SYNMarburg (Marburg, Germany)
2015/07 Manipulation of bacterial interspecies Quorum Sensing in the mouse gut
Instituto de Medicina Molecular (Lisboa, Portugal)
2015/07 Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota 8th Congress of the International Symbiosis Society
(Lisboa, Portugal)
2015/05 Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota Bacterial Networks (BACNET/15) – ESF-EMBO Symposium
(Spain)
2015/03 Manipulation of bacterial interspecies Quorum Sensing in the mouse gut
Laboratoire de Chimie Bactérienne (Marseille, France)
2015/02 Manipulation of bacterial interspecies Quorum Sensing in the mouse gut Centre of Excellence in Bacteriology
University of Geneva (Geneva, Switzerland)
2015/02 Manipulation of bacterial interspecies Quorum Sensing in the mouse gut
Faculdade Ciências, Universidade de Lisboa (Lisboa, Portugal)
2014/11 Manipulating the Interspecies Quorum Sensing Signal AI-2 in the Mouse Gut HHMI Scientific Meeting
Janelia Farm Research Campus (Virginia, United States)
2014/10 Manipulating the Interspecies Quorum Sensing Signal AI-2 in the Mouse Gut 5th ASM Conference on Cell-Cell Communication in Bacteria
(San Antonio, Texas, United States)
2014/06 Manipulating interspecies quorum sensing in bacterial consortia
Universidade de Coimbra (Coimbra, Portugal)
2014/05 Small RNAs are central in integrating quorum sensing signals in plant associated pathogens RNA Workshop: Post-Transcriptional Control of Microbial Gene Expression
ITQB (Oeiras, Portugal)
2014/05 Manipulating interspecies quorum sensing in the mouse gut 3rd Mol Micro Meeting
(Würzburg, Germany)
2014/04 Manipulating interspecies quorum sensing in bacterial consortia
College of Life Sciences, University of Dundee (Dundee, Scotland, United Kingdom)
2014/03 Manipulating interspecies quorum sensing in bacterial consortia
Max Planck Institute for Infection Biology (Berlin, Germany)
2014/01 Cell-cell communication in multispecies bacterial communities
Faculdade de Ciencias, Universidade de Lisboa (Lisboa, Portugal)
2013/11 Sensing and processing the interspecies quorum sensing signal AI-2
Department of Microbiology and Molecular Genetics & Public Health Research Institute, Rutgers University (New Jersey, United States)
2013/07 Regulation of the AI-2 quorum sensing signal FEMS Microbiology Congress 2013
(Germany)
2013/06 Sensing and processing the interspecies quorum sensing signal AI-2 Society for General Microbiology (SGM) sponsored seminar
Department of Biology, University of York (York, United Kingdom)
2013/06 Sensing and processing the interspecies quorum sensing signal AI-2
ZMBH, University of Heidelberg (Heidelberg, Germany)
2013/05 Escherichia coli adaptation to the mouse gut Cell Symposia: Microbiome and Host Health
(Lisboa, Portugal)
2013/03 Adaptation of Escherichia coli in the mouse gut Bacterial Networks (BACNET/13) – ESF-EMBO Symposium
(Poland)
2012 Interference with bacterial inter-species quorum sensing
Center for integrated protein science, Ludwig-Maximilians-Universitaet Muenchen (Munich, Germany)
2010/09 The LsrB family of receptors for the inter-species quorum sensing signal AI-2 Bacterial Networks (BACNET/10) - ESF
(Sant Feliu de Guixols, Spain)
2010/07 Interference with Inter-species Quorum Sensing Symposium - SMALL TALK: Chemical Communication in Bacteria
Danish Society for Biochemistry and Molecular Biology and Danish Biotechnology Society (Copenhagen, Denmark)
2010 Bacterial Languages
Centro de Malária e Doenças Tropicais, Instituto de Higiene e Medicina Tropical (Lisboa, Portugal)
2009 Quorum Sensing and Inter-Species Communication in Bacteria
Instituto de Biologia Molecular e Cellular, Universidade do Porto (Porto, Portugal)
2009 Quorum Sensing: The chemical language of bacteria
Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (Lisboa, Portugal)
2009 Interference with bacterial communication
Department of Chemistry and Biochemistry, Universidade de Lisboa (Lisboa, Portugal)
2008/07 Processing the inter-species quorum sensing signal AI-2 Gordon Research Conference on Microbial Stress Response
Mount Holyoke College South Hadley (Hadley, United States)
2008/04 Small non-coding RNAs controlling pathogenesis 18th European Congress of Clinical Microbiology and Infectious Diseases
(Barcelona, Spain)
2008 Quorum Sensing in Bacteria
Center for Neuroscience and Cell Biology, Universidade de Coimbra (Coimbra, Portugal)
2008 Quorum Sensing in Bacteria
Instituto de Medicina Molecular, Universidade de Lisboa (Lisboa, Portugal)
2007 Bacterial Inter-species Communication
Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (Lisboa, Portugal)
2007 Communication in bacteria
Department of Chemistry and Biochemistry, Universidade de Lisboa (Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2016/01/01 - 2021/02/18 Regulation of virulence in the vector borne plant pathogen Erwinia carotovora
Supervisor
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/09/01 - 2021/01/18 Characterization of growth and quorum sensing responses in Barnesiella and Muribaculum gut microbiota members
Supervisor
 Molecular Genetics and Biomedicine
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2020 Interspecies interactions in recovery of gut microbiota functions.
Supervisor
 Host-microbe interactions (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018 - 2019 Identification of Mechanisms of Colonization Resistance of Commensal Klebsiella spp. against other Proteobacteria
Supervisor
 Medical Microbiology (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2019 Discovery of novel autoinducer-2 receptors
Supervisor
 Biochemistry (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015 - 2019 Synthesis of new bioactive autoinducer-2 analogues
Co-supervisor
 Chemistry (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012 - 2017 Genetic Bases of Cooperator/Cheater Dynamics in Bacterial Populations
Supervisor
 Biologia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015 - 2016 Metabolic-derived functions during adaptation of E. coli to the mammalian gut
Supervisor
 Molecular Biology and Genetics (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2013 - 2014 The impact of the phytopathogen Pectobacterium carotovorum in Drosophila melanogaster development
Supervisor
 Applied Microbiology (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2009 - 2014 Cell-to-cell Communication in Pectobacterium wasabiae
Supervisor
 Biologia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012 - 2013 The Lsr system : a switcher for bacterial behaviours?
Supervisor
 Biopharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2011 Regulation of the Mechanism of interference with quorum sensing in Escherichia coli
Supervisor
 Applied Microbiology (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2007 - 2011 Bacterial inter-species communication mediated by the autoinducer-2 signal
Supervisor
 Biologia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2008 - 2009 Comunicação inter-específica e o seu efeito na taxa de mutação em Escherichia coli
Supervisor
 Evolutionary Biology and Development (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2008 - 2009 Influência do sistema biossensor de quórum via AI-2 para a colonização do ambiente intestinal de mamíferos
Supervisor
 Evolutionary Biology and Development (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2006 - 2007 Termination of the AI-2 signalling cycle in enteric bacteria.
Supervisor
 Cell Biology and Biotechnology (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016 - Current International Symposium at the College France: “Communication among Complex Microbial Populations and Their Host”. May 30 – 31, 2016 Member of Scientific Committee with: Brett Finlay, Jean-Marc Ghigo, Philippe Sansonetti. (2016/05/30 - 2016/05/31)
Symposium (Member of the Scientific Committee)
 Collège de France, France
2015/07 - Current International PhD Summer School on “Host-microbe symbioses” – Organizer. Five editions, two weeks course run in July 2023 / 2022 / 2019 / 2017 / 2015 at IGC, PT. First edition was in 2015 and was co-organized by myself, L.Teixeira (IGC), M. Blaser (now at Rutgers Univ.), M. McFall-Ngai (now at Carnegie), later joined by Thomas Bosch (Kiel Univ). In each of the 5 editions we had 30-35 students, from more than 17 different nationalities and 14 International speakers. (2015/07)
Meeting (Co-organisor)
 Instituto Gulbenkian de Ciência, Portugal
2022/01/13 - 2022/01/14 Global Microbiome Network Symposium – GloMiNe Symposium for Africa – Organizer. Online Event, 518 Participants from 46 Countries. Jan 13-14, 2022. (2022/01/13 - 2022/01/14)
Symposium
 Instituto Gulbenkian de Ciência, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2007 - Current IGC PhD Program in Integrative Biomedical Sciences Co-organizer and Lecturer of the course: Host-Pathogen Interactions (2017 to 2019); Co-organizer and Lecturer of the course: From cells to organisms (2012 to 2016 and 2021); Lecturer in the course: Between Cells (2007 to 2011). Instituto Gulbenkian de Ciência, Portugal
2007 - Current Responsible for Curricular Unit and Lecturer “Evolution and Dynamics of the Host-Microbe Interactions” in the PhD Program – Biology at the Host-Microbe Interface (2018-Present) and “Ecology and Evolution of Microbial Populations” in the PhD Program – Molecular Biosciences (2014-present). Lecturer in “Bacterial Quorum Sensing” and Tutorials in “Cell-cell signalling” postgraduate course (2009-2013). Lecturer and Co-Organizer of the week course “Microbial Physiology and Pathogenesis” (2007 and 2008). Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009 - 2012 IGC Programme for Advanced Medical Education – From 2009-2012 – Lecturer in the “Host-Pathogen Interactions” course. Instituto Gulbenkian de Ciência, Portugal
2001 - 2002 Advanced Microbial Genetics Graduate Course - Fall term. Princeton University, Molecular Biology Department - 2001/2002. Lecturer Princeton University, United States

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2020 - 2023 Member of the Scientific Advisory Board of the HELMHOLTZ CENTRE FOR INFECTION RESEARCH
Member
 Helmholtz-Zentrum für Infektionsforschung Abteilung Genregulierung und -differenzierung, Germany
2014 - 2016 Panel Member of European Research Council (ERC) Panel Member for LS6, Immunity and Infection, Consolidator calls 2014 and 2016.
Member
 European Research Council, Belgium
2015 - 2015 Panel Member in the qualitative evaluation of completed ERC-funded projects, 2015. Panel LS6 - Infection and Immunity.
Member
 European Research Council, Belgium
2010 - 2010 FCT. Call for applications for Individual Grants 2010. Panel Member.
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal
2008 - 2008 FCT. Call for applications for Individual Grants 2008. Panel Member. Fundação para a Ciência e a Tecnologia, Portugal

Other jury / evaluation

Activity description Institution / Organization
2007 - Current Ad hoc Grant Reviewer: ERC- Starter and Consolidator, 2018-2019. Welcome Trust Investigator Awards 2016-2017. Human Frontier Science Program - Career Development Award, 2014. Israel Science Foundation, Individual Research Grant 2009 and 2018. BBSRC, UK – Research Grants, 2015. National Science Foundation (NSF, USA), 2013 program Postdoctoral Research Fellowships in Biology. University of Copenhagen, Department of Biology. Assessment Committee for Associate Professor. 2011. Netherlands Organization for Scientific Research. Innovational. 2007
2006 - Current Reviewing Manuscript: Elife (as editor); Cell Reports; PNAS; Cell Host-Micro; Molecular Microbiology - Blakwell Publishing; Plos Biology; Plos Pathogen; Plos One; Sci. Reports; American Society for Microbiology: Journal of Bacteriology, MBio, and Applied Environmental Microbiology; J. Med. Micro.; Nature Rev. Micro; Nature Communication; ISME; ACS Synthetic Biol; ACS Nano Particles; Trends in Micro; Trends in Ecology and Evolution; BMC Microbiology. https://publons.com/researcher/1195370/karina-xavier/
Distinctions

Award

2017 FCT Investigator Programme - Consolidator Award, 2017-2022.
Fundação para a Ciência e a Tecnologia, Portugal
2015 PLOS Genetics Research Prize 2015
Plos, United States
2014 NIH Travel Award for the 5th ASM Conference on Cell-Cell Communication in Bacteria
2012 Howard Hughes Medical Institute International Early Career Award
Howard Hughes Medical Institute, United States

Other distinction

2022 Elected to the American Academy of Microbiology
American Academy of Microbiology, United States
2022 Appointed member of Editorial Board at mBio
American Society for Microbiology, United States
2021 Elected EMBO Member
EMBO, Germany
2019 Elected Member of European Academy of Microbiology (EAM)
Federation Of European Microbiological Societies, Netherlands
2019 Appointed eLlife Board of Reviewing Editors
eLife Sciences Publications Ltd, United Kingdom