Cristina Cunha (6719-B9AE-4AB5)

Curriculum Vitae

Cristina Cunha

Cristina Cunha graduated in Biology from the University of Minho in 2007 and received a PhD in Biology and Experimental Medicine in 2013 from the University of Perugia, Italy. Between 2014 and 2019, she developed postdoctoral studies on the genetic basis of susceptibility to fungal infection at the Life and Health Sciences Research Institute (ICVS) of the University of Minho. Since 2020, she has been an Assistant Researcher at ICVS, where she is focusing her research on deciphering the contribution of the crosstalk between genetics, immunology, and metabolism to the susceptibility to infectious and inflammatory diseases. This multidisciplinary approach has allowed her to develop cutting-edge research and deliver important contributions towards the elucidation of the molecular and cellular events that regulate immunity and inflammation, contributing to the identification of novel prognostic, diagnostic, and therapeutic targets for personalized medical interventions. Her track record is currently mirrored by 107 publications in international peer-reviewed journals (>5,400 citations and h-index=35, ISI Web of Knowledge; January 2024) and 7 book chapters. In particular, she is the senior author of recent papers in Thorax 2022 and Nat Commun 2020, besides first authorship papers in high-impact journals, such as JACI 2017, N Engl J Med 2014, and Blood 2010. She has also relevant collaborations in Lancet Microbe 2024, Cell Host Microbe 2023, Nat Microbiol 2022, Lancet Respir Med 2022, Nature 2018, Nat Microbiol 2018, Immunity 2013, Cell Metab 2016, and Nat Commun 2021. She is the Principal Investigator of 6 grants funded by the "la Caixa" Foundation, Institut Mérieux, Gilead Sciences, and the Fundação para a Ciência e a Tecnologia (FCT), and she is involved as a researcher in several other national and international grants (e.g., H2020 and "la Caixa" Foundation). She has supervised 3 post-doctoral fellows, 5 PhD students, and 9 MSc students, and co-organized one international scientific conference. As a result of her contributions to the field over the years, she has received multiple prizes or awards, including the Jon van Rood Award for outstanding contributions in the field of immunogenetics. She was recently nominated as a Gilead Research Scholar in Antifungals.

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Identification

Personal identification

Full name: Cristina Cunha

Citation names

Cunha, Cristina

Author identifiers

Ciência ID: 6719-B9AE-4AB5
ORCID iD: 0000-0002-6002-5782
Google Scholar ID: 0O7w_fcAAAAJ&hl
Researcher Id: D-2687-2009
Scopus Author Id: 57097771800

Email addresses

cristinacunha@med.uminho.pt (Professional)

Telephones

Telephone

253604945 (Professional)

Addresses

Instituto de Investigação em Ciências da Vida e Saúde (ICVS), Escola de Medicina, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, 4710-057, Braga, Braga, Portugal (Professional)

Websites

https://www.researchgate.net/profile/Cristina_Cunha6 (Professional)
http://www.icvs.uminho.pt/research-scientists/microbiology--infection/people/cristinacunha (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Cell Biology
Medical and Health Sciences - Health Sciences - Infectious Diseases
Medical and Health Sciences - Basic Medicine - Human Genetics
Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
Spanish; Castilian	Intermediate (B1)	Advanced (C1)	Beginner (A1)	Intermediate (B1)	Advanced (C1)
Italian	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2013 Concluded	Dottorato in Biologia e Medicina Sperimentale (PhD in Biology and Experimental Medicine) (Dottorato di Ricerca) Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy "Genetic susceptibility to invasive aspergillosis in the hematopoietic stem cell transplantation setting" (THESIS/DISSERTATION)	Approved
2007 Concluded	Licenciatura em Biologia Aplicada (Degree in Applied Biology) (Licenciatura) Universidade do Minho Escola de Ciências, Portugal "Evaluation of the cellular division process by multiple budding of dimorphic pathogenic fungus Paracoccidioides brasiliensis" (THESIS/DISSERTATION)	14

Affiliation

Science

	Category Host institution	Employer
2020 - Current	Auxiliary Researcher (Research)	Universidade do Minho Escola de Medicina, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2020	Contracted Researcher (Research)	Universidade do Minho Escola de Medicina, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014 - 2019	Postdoc (Research)	Universidade do Minho Escola de Medicina, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2013	Researcher (Research)	Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy
	Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy
2008 - 2009	Visiting Researcher (Research)	Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy
	Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy
2007 - 2008	Visiting Researcher (Research)	Universidade do Minho Escola de Medicina, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2007	Research Trainee (Research)	Universidade do Minho Escola de Medicina, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Projects

Grant

	Designation	Funders
2023/01 - 2025/12	Metabolic control of immune cell function in respiratory fungal disease 2022.06674.PTDC Principal investigator Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/10 - 2025/09	Whole-systems analysis of the microbiome-metabolome crosstalk for biomarker discovery and therapy of respiratory fungal diseases LCF/PR/HR22/00879 Principal investigator Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Obra Social La Caixa Ongoing
2022 - 2024	Immunometabolic regulation of granulomatous inflammation in sarcoidosis PTDC/MED-OUT/1112/2021 Co-Principal Investigator (Co-PI) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020 - 2024	HDM-FUN: Host-directed medicine in invasive fungal infection 847507 Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	EU Framework Programme for Research and Innovation Health Demographic Change and Wellbeing Ongoing
2021 - 2023	Host-microbiome interactions in the quest for Fibrosing ILD Biomarkers that Rule Acceleration (FIBRA-Lung) PTDC/MEC-RES/0158/2020 Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021 - 2023	Dissecting itaconate-mediated mechanisms of antifungal activity in invasive pulmonary aspergillosis Gilead Research Scholars – Anti-Fungals Principal investigator Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Gilead Sciences Europe Ltd Concluded
2019 - 2023	TRANS-CPA: A transdisciplinary approach to the identification of personalized biomarkers and therapeutic targets for chronic pulmonary aspergillosis LCF/PR/HP17/52190003 Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Obra Social La Caixa Fundação para a Ciência e a Tecnologia Concluded
2018 - 2022	Innate regulation of inflammation in sarcoidosis PTDC/MED-GEN/28778/2017 Principal investigator Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018 - 2022	The host-microbiota interaction in fungal diseases: towards biomarker discovery and therapy PTDC/SAU-SER/29635/2017 Principal investigator Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016 - 2020	Predictive diagnostics and personalized treatment of infectious diseases in patients with hematological malignancies: immunometabolic and genetic control of susceptibility NORTE-45-2015-02 Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Concluded
2015 - 2020	The role of inflammasome-autophagy crosstalk in fungal infection IF/00735/2014 Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2017 - 2019	The genetic architecture of the immune response to Aspergillus fumigatus: from biological understanding to therapeutic intervention Mérieux Research Grant 2017 Principal investigator Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Institut Mérieux Concluded
2017 - 2019	The genetic architecture of the immune response to Aspergillus fumigatus: from biological understanding to therapeutic intervention ESCMID Research Grant 2017 Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	European Society of Clinical Microbiology and Infectious Diseases Concluded
2017 - 2018	PTX3-mediated innate regulation of inflammation in sarcoidosis 2-CA Grant 2017 Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	2CA- Clinic Academic Center Concluded
2017 - 2018	O papel da sobreexpressão de IL-10 na imunidade antifúngica e no risco de infeção fúngica em doentes imunocomprometidos Ações Integradas Luso-Alemãs A-43/16 Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Conselho de Reitores das Universidades Portuguesas (CRUP) Concluded
2016 - 2018	Translating the host-microbiota interaction into risk assessment of fungal diseases Mérieux Research Grant 2016 Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Institut Mérieux Concluded
2012 - 2015	Interaction between immune genes and quality of caregiver's behaviours for child's attachment outcomes PTDC/PSI-PCL/116897/2010 Researcher Universidade do Minho Centro de Investigação em Psicologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2014	Genetic variants of PTX3 and invasive aspergillosis: from risk assessment to mechanistic insights ESCMID Research Grant 2012/5 Researcher Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy	European Society of Clinical Microbiology and Infectious Diseases Concluded
2012 - 2014	Targeting pathogenic pathways leading to inflammatory Th17 responses in cystic fibrosis: a drug discovery approach FFC#16/2012 Researcher Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy	Fondazione per La Ricerca sulla Fibrosi Cistica Concluded
2012 - 2014	FunMeta: Metabolomics of fungal diseases: a systems biology approach for biomarkers discovery and therapy ERC-2011-AdG-293714 Researcher Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy	European Research Council Concluded
2010 - 2014	ALLFUN: Fungi in the setting of inflammation, allergy and autoimmune diseases: translating basic sciences into clinical practices HEALTH-F2-2010-260338 Researcher Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy	European Commission Seventh Framework Programme for Research and Technological Development Concluded
2012 - 2013	Genetic polymorphisms in patients with invasive aspergillosis: a new frontier for diagnosis and therapy Gilead Fellowship Program 2012 Researcher Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy	Gilead Sciences Concluded
2010 - 2013	The Th17 pathway: new insights into the pathogenesis and treatment of immunoreconstitution diseases through a systems biology approach RF-PGN-2009-1302800 Researcher Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy	Ministero della Salute Concluded
2010 - 2012	Th17 responses in cystic fibrosis: paving the way for novel anti-inflammatory strategies and immunogenetic screening FFC#21/2010 Researcher Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy	Fondazione per la Ricerca sulla Fibrose Cistica Concluded

Contract

	Designation	Funders
2024 - Current	Dissecting the role of interleukin-37 in the metabolic regulation of antifungal immunity 2023.02637.BD Supervisor Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2024 - Current	Metabolic regulation of granulomatous inflammation by tryptophan catabolism 2023.03013.BD Supervisor Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2023 - Current	Metabolic circuits of immune regulation and function during fungal infection 2022.12062.BD Supervisor Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020 - Current	A Synthetic Biology Approach to the Microbiome-Metabolome Crosstalk in Respiratory Fungal Diseases CEECIND/04058/2018 Principal investigator Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/09 - 2022/10	Metabolic regulation of antifungal immunity through the mevalonate pathway SFRH/BD/136814/2018 Supervisor Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/09 - 2022/10	Innate regulation of antifungal immunity in chronic obstructive pulmonary disease SFRH/BD/141127/2018 Supervisor Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019 - 2020	Whole-systems Analysis of the Microbiome-Metabolome Crosstalk for Biomarker Discovery and Therapy of Respiratory Fungal Diseases CEECIND/04601/2017 Principal investigator Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014 - 2019	THE ROLE OF INFLAMMASOME ACTIVATION IN HOST IMMUNITY TO FUNGAL INFECTION SFRH/BPD/96176/2013 Post-doc Fellow Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010 - 2013	Genetic susceptibility to invasive aspergillosis in the hematopoietic stem cell transplantation setting SFRH/BD/65962/2009 PhD Student Fellow Università degli Studi di Perugia Dipartimento di Medicina Sperimentale, Italy	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Gonçalves, S.M.; Duarte-Oliveira, C.; Cunha, C.; Carvalho, A.. "The lung microbiome, metabolome, and breath volatolome in the diagnosis of pulmonary disease". In Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications, 297-305. National Academies Press, 2019. 10.1016/B978-0-12-815249-2.00031-2 Cunha, C.; Gonçalves, S.M.; Carvalho, A.. "Role of deficits in pathogen recognition receptors in infection susceptibility". In Management of Infections in the Immunocompromised Host, 115-131. Springer International Publishing, 2018. 10.1007/978-3-319-77674-3_6 Rodrigues, Cláudia S.; Campos, Cláudia F.; Cunha, Cristina; Carvalho, Agostinho. "Metabolic Regulation of Innate Immunity to Fungal Infection". In Metabolic Interaction in Infection, 403-420. Springer International Publishing, 2018. 10.1007/978-3-319-74932-7_11 Campos, Cláudia F.; van de Veerdonk, Frank L.; Gonçalves, Samuel M.; Cunha, Cristina; Netea, Mihai G.; Carvalho, Agostinho. "Host Genetic Signatures of Susceptibility to Fungal Disease". In Current Topics in Microbiology and Immunology, 237-263. Springer International Publishing, 2018. 10.1007/82_2018_113 Cunha, C.; Gonçalves, S.M.; Carvalho, A.. "Host-derived biomarkers for risk assessment of invasive fungal diseases". 153-165. 2017. 10.1007/978-1-4939-6515-1_7 Carvalho, Agostinho; Cunha, Cristina; Galosi, Claudia; Romani, Luigina. "Antifungal Vaccines and Immunotherapeutics". In Antifungals: From Genomics to Resistance and the Development of Novel Agents, 267-288. Caister Academic Press, 2015. 10.21775/9781910190012.12 Cunha, Cristina; Aversa, Franco; Romani, Luigina; Carvalho, Agostinho. "T Cell Responses in Fungal Infections". In Human Fungal Pathogens, 109-127. Springer Berlin Heidelberg, 2013. 10.1007/978-3-642-39432-4_6
Conference abstract	Parente, R.; Possetti, V.; Stravalaci, M.; Sironi, M.; Valentino, S.; Day, A.; Bottazzi, B.; et al. "The alternative pathway of complement and long pentraxin PTX3 form a functional axis in the immune response to Aspergillus fumigatus". Paper presented in ICW – 2021 Virtual Workshop of the International Complement Society (ICS), 2022.
Journal article	Feys, S.; Vanmassenhove, S.; Kraisin, S.; Yu, K.; Jacobs, C.; Boeckx, B.; Cambier, S.; et al. "Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study". The Lancet Microbe (2024): 10.1016/S2666-5247(23)00368-3 Fernandes, R.; Sabino, R.; Cunha, C.; Cornely, O.A.; Carvalho, A.; Salmanton-García, J.. "Multicentric Study on the Clinical Mycology Capacity and Access to Antifungal Treatment in Portugal". Mycopathologia 189 1 (2024): 15. 10.1007/s11046-024-00830-9 Vieira, S.F.; Gonçalves, S.M.; Gonçalves, V.M.F.; Llaguno, C.P.; Macías, F.; Tiritan, M.E.; Cunha, C.; et al. "Echinacea purpurea Fractions Represent Promising Plant-Based Anti-Inflammatory Formulations". Antioxidants 12 2 (2023): 425. 10.3390/antiox12020425 Antunes, D.; Gonçalves, S.M.; Matzaraki, V.; Rodrigues, C.S.; Gonçales, R.A.; Rocha, J.; Sáiz, J.; et al. "Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus". Microbiology Spectrum 11 1 (2023): e0225622. 10.1128/spectrum.02256-22 Jia, L.-J.; Rafiq, M.; Radosa, L.; Hortschansky, P.; Cunha, C.; Cseresnyés, Z.; Krüger, T.; et al. "Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway". Cell Host & Microbe 31 3 (2023): 373-388. 10.1016/j.chom.2023.02.002 Feys, S.; Heylen, J.; Carvalho, A.; Van Weyenbergh, J.; Wauters, J.; Gonçalves, S.M.; Cunha, C.; et al. "A signature of differential gene expression in bronchoalveolar lavage fluid predicts mortality in influenza-associated pulmonary aspergillosis". Intensive Care Medicine 49 2 (2023): 254-257. 10.1007/s00134-022-06958-w Araújo, M.; Moreira, D.; Mesquita, I.; Ferreira, C.; Mendes-Frias, A.; Barros-Carvalho, S.; Dinis-Oliveira, R.J.; et al. "Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis". Immunology 170 4 (2023): 510-526. 10.1111/imm.13686 Tavares, M.; Sousa-Filho, J.C.; Machado, I.A.; Gonçales, R.A.; Antunes, D.; Mendes-Frias, A.; Silvestre, R.; et al. "Development of a Versatile Toolbox for Genetic Manipulation of Sporothrix brasiliensis". Microbiology Spectrum 11 2 (2023): e0456422. 10.1128/spectrum.04564-22 Hérivaux, A.; Willis, J.R.; Mercier, T.; Lagrou, K.; Goncalves, S.M.; Goncales, R.A.; Maertens, J.; et al. "Lung microbiota predict invasive pulmonary aspergillosis and its outcome in immunocompromised patients". Thorax 73 3 (2022): 283-291. 10.1136/thoraxjnl-2020-216179 Gonçalves, S.M.; Ferreira, A.V.; Cunha, C.; Carvalho, A.. "Targeting immunometabolism in host-directed therapies to fungal disease". Clinical and Experimental Immunology 208 2 (2022): 158-166. 10.1093/cei/uxab014 Gonçalves, S.M.; Cunha, C.; Carvalho, A.. "Understanding the genetic basis of immune responses to fungal infection". Expert Review of Anti-Infective Therapy 20 7 (2022): 987-996. 10.1080/14787210.2022.2063839 Hoenigl, M.; Seidel, D.; Sprute, R.; Cunha, C.; Oliverio, M.; Goldman, G.H.; Ibrahim, A.S.; Carvalho, A.. "COVID-19-associated fungal infections". Nature Microbiology 7 8 (2022): 1127-1140. 10.1038/s41564-022-01172-2 da Silva-Ferreira, S.; Duarte-Oliveira, C.; Antunes, D.; Barbosa-Matos, C.; Mendes-Frias, A.; Torrado, E.; Costa, S.; et al. "Hypoxia inducible-factor 1 alpha regulates neutrophil recruitment during fungal-elicited granulomatous inflammation". Frontiers in Cellular and Infection Microbiology 12 (2022): 1005839. 10.3389/fcimb.2022.1005839 Wang, X.; Cunha, C.; Grau, M.S.; Robertson, S.J.; Lacerda, J.F.; Campos, A.; Lagrou, K.; et al. "MAVS Expression in Alveolar Macrophages Is Essential for Host Resistance against Aspergillus fumigatus". Journal of Immunology 209 2 (2022): 346-353. 10.4049/jimmunol.2100759 Olival, A.; Vieira, S.F.; Gonçalves, V.M.F.; Cunha, C.; Tiritan, M.E.; Carvalho, A.; Reis, R.L.; Ferreira, H.; Neves, N.M.. "Erythrocyte-derived liposomes for the treatment of inflammatory diseases". Journal of Drug Targeting 30 8 (2022): 873-883. 10.1080/1061186X.2022.2066107 Feys, S.; Gonçalves, S.M.; Khan, M.; Choi, S.; Boeckx, B.; Chatelain, D.; Cunha, C.; et al. "Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study". The Lancet Respiratory Medicine 10 12 (2022): 1147-1159. 10.1016/S2213-2600(22)00259-4 Matzaraki, V.; Beno, A.; Jaeger, M.; Gresnigt, M.S.; Keur, N.; Boahen, C.; Cunha, C.; et al. "Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis". Redox Biology 55 (2022): 102391. 10.1016/j.redox.2022.102391 Gonçales, R.A.; Bastos, H.N.; Duarte-Oliveira, C.; Antunes, D.; Sokhatska, O.; Jacob, M.; Rolo, R.; et al. "Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis". American Journal of Respiratory and Critical Care Medicine 206 9 (2022): 1140-1152. 10.1164/rccm.202112-2771OC Ferreira, C.M.; Micheli, C.; Barreira-Silva, P.; Barbosa, A.M.; Resende, M.; Vilanova, M.; Silvestre, R.; et al. "IL-10 Overexpression After BCG Vaccination Does Not Impair Control of Mycobacterium tuberculosis Infection". Frontiers in Immunology 13 (2022): 10.3389/fimmu.2022.946181 Bernal-Martínez, L.; Gonçalves, S.M.; de Andres, B.; Cunha, C.; Gonzalez Jimenez, I.; Lagrou, K.; Mellado, E.; et al. "TREM1 regulates antifungal immune responses in invasive pulmonary aspergillosis". Virulence 12 1 (2021): 570-583. 10.1080/21505594.2021.1879471 Lima, A.C.; Campos, C.F.; Cunha, C.; Carvalho, A.; Reis, R.L.; Ferreira, H.; Neves, N.M.. "Biofunctionalized Liposomes to Monitor Rheumatoid Arthritis Regression Stimulated by Interleukin-23 Neutralization". Advanced Healthcare Materials 10 2 (2021): e2001570. 10.1002/adhm.202001570 Fevereiro, J.; Fraga, A.G.; Capela, C.; Sopoh, G.E.; Dossou, A.; Ayelo, G.A.; Peixoto, M.J.; et al. "Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer". Emerging Microbes and Infections 10 1 (2021): 223-225. 10.1080/22221751.2021.1878936 Sánchez-Maldonado, J.M.; Moñiz-Díez, A.; Ter Horst, R.; Campa, D.; Cabrera-Serrano, A.J.; Martínez-Bueno, M.; Garrido-Collado, M.P.; et al. "Polymorphisms within the TNFSF4 and MAPKAPK2 loci influence the risk of developing invasive aspergillosis: A two-stage case control study in the context of the aspbiomics consortium". Journal of Fungi 7 1 (2021): 1-17. 10.3390/jof7010004 Doni, A.; Parente, R.; Laface, I.; Magrini, E.; Cunha, C.; Colombo, F.S.; Lacerda, J.F.; et al. "Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus". Nature Communications 12 1 (2021): 3739. 10.1038/s41467-021-24021-y Gonçales, R.A.; Ricci-Azevedo, R.; Vieira, V.C.S.; Fernandes, F.F.; Thomaz, S.M.D.O.; Carvalho, A.; Vendruscolo, P.E.; et al. "Paracoccin Overexpression in Paracoccidioides brasiliensis Enhances Fungal Virulence by Remodeling Chitin Properties of the Cell Wall". Journal of Infectious Diseases 224 1 (2021): 164-174. 10.1093/infdis/jiaa707 Castro, I.; Sampaio-Marques, B.; Areias, A.C.; Sousa, H.; Fernandes, Â.; Sanchez-Maldonado, J.M.; Cunha, C.; et al. "Functional genetic variants in ATG10 are associated with acute myeloid leukemia". Cancers 13 6 (2021): 1-16. 10.3390/cancers13061344 Dewi, I.M.W.; Cunha, C.; Jaeger, M.; Gresnigt, M.S.; Gkountzinopoulou, M.E.; Garishah, F.M.; Duarte-Oliveira, C.; et al. "Neuraminidase and SIGLEC15 modulate the host defense against pulmonary aspergillosis". Cell Reports Medicine 2 5 (2021): 100289. 10.1016/j.xcrm.2021.100289 Gonçalves, S.M.; Antunes, D.; Leite, L.; Mercier, T.; Horst, R.T.; Vieira, J.; Espada, E.; et al. "Genetic variation in PFKFB3 impairs antifungal immunometabolic responses and predisposes to invasive pulmonary aspergillosis". mBio 12 3 (2021): e0036921. 10.1128/mBio.00369-21 Sueiro-Olivares, M.; Scott, J.; Gago, S.; Petrovic, D.; Kouroussis, E.; Zivanovic, J.; Yu, Y.; et al. "Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response". PLoS Biology 19 6 (2021): e3001247. 10.1371/journal.pbio.3001247 Ferreira, C.M.; Barbosa, A.M.; Barreira-Silva, P.; Silvestre, R.; Cunha, C.; Carvalho, A.; Rodrigues, F.; et al. "Early IL-10 promotes vasculature associated CD4+ T cells unable to control Mycobacterium tuberculosis infection". JCI Insight 6 21 (2021): e150060. 10.1172/jci.insight.150060 Mesquita, I.; Ferreira, C.; Moreira, D.; Kluck, G.E.G.; Barbosa, A.M.; Torrado, E.; Dinis-Oliveira, R.J.; et al. "The Absence of HIF-1a Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis". Cell Reports 30 12 (2020): 4052-4064.e7. 10.1016/j.celrep.2020.02.098 Mondanelli, G.; Coletti, A.; Greco, F.A.; Pallotta, M.T.; Orabona, C.; Iacono, A.; Belladonna, M.L.; et al. "Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation". Proceedings of the National Academy of Sciences of the United States of America 117 7 (2020): 3848-3857. 10.1073/pnas.1918215117 Lupiañez, C.B.; Martínez-Bueno, M.; Sánchez-Maldonado, J.M.; Badiola, J.; Cunha, C.; Springer, J.; Lackner, M.; et al. "Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis". Infection and Immunity 88 4 (2020): e00882-19. 10.1128/IAI.00882-19 Pinto, R.; Belsky, J.; Baptista, J.; Carvalho, A.; Cunha, C.; Soares, I.; Mesquita, A.R.. "Mothers' distress exposure and children's withdrawn behavior – A moderating role for the Interferon Gamma gene (IFNG)". Developmental Psychobiology 62 6 (2020): 783-791. 10.1002/dev.21955 Ferreira, C.; Mesquita, I.; Barbosa, A.M.; Osório, N.S.; Torrado, E.; Beauparlant, C.-J.; Droit, A.; et al. "Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis". 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Journal of Pharmaceutical and Biomedical Analysis 189 (2020): 113473. 10.1016/j.jpba.2020.113473 Sánchez-Maldonado, J.M.; Campa, D.; Springer, J.; Badiola, J.; Niazi, Y.; Moñiz-Díez, A.; Hernández-Mohedo, F.; et al. "Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium". Blood Cancer Journal 10 7 (2020): 75. 10.1038/s41408-020-00341-y Gonçalves, S.M.; Duarte-Oliveira, C.; Campos, C.F.; Aimanianda, V.; ter Horst, R.; Leite, L.; Mercier, T.; et al. "Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity". Nature Communications 11 1 (2020): 2282. 10.1038/s41467-020-16120-z Ferreira, B.H.; Ramírez-Prado, J.H.; Neves, G.W.P.; Torrado, E.; Sampaio, P.; Felipe, M.S.S.; Vasconcelos, A.T.; et al. "Ploidy determination in the pathogenic fungus Sporothrix spp". Frontiers in Microbiology 10 FEB (2019): 284. 10.3389/fmicb.2019.00284 Antunes, D.; Cunha, C.; Carvalho, A.. "Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis". Current Fungal Infection Reports 13 3 (2019): 77-85. 10.1007/s12281-019-00344-8 Bernal-Martínez, L.; Alcazar Fuoli, L.; Miguel-Revilla, B.; Carvalho, A.; Cuétara Garcia, M.S.; Garcia-Rodriguez, J.; Cunha, C.; Gómez-García de la Pedrosa, E.; Gomez-Lopez, A.. "High-resolution melting assay for genotyping variants of the CYP2C19 enzyme and predicting voriconazole effectiveness". Antimicrobial Agents and Chemotherapy 63 6 (2019): e02399-18. 10.1128/AAC.02399-1 Campos, C.F.; Leite, L.; Pereira, P.; Vaz, C.P.; Branca, R.; Campilho, F.; Freitas, F.; et al. "PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantation". Frontiers in Immunology 10 JAN (2019): 88. 10.3389/fimmu.2019.00088 Bacelo, E.; Da Silva, M.A.; Cunha, C.; Faria, S.; Carvalho, A.; Reis, R.L.; Martins, A.; Neves, N.M.. "Biofunctional nanofibrous substrate for local TNF-capturing as a strategy to control inflammation in arthritic joints". Nanomaterials 9 4 (2019): 88. 10.3390/nano9040567 Cunha, C.; Carvalho, A.. "Genetic defects in fungal recognition and susceptibility to invasive pulmonary aspergillosis". Medical Mycology 57 (2019): S211-S218. 10.1093/mmy/myy057 Campos, C.F.; van de Veerdonk, F.L.; Gonçalves, S.M.; Cunha, C.; Netea, M.G.; Carvalho, A.. "Host genetic signatures of susceptibility to fungal disease". Current Topics in Microbiology and Immunology 422 (2019): 237-263. 10.1007/82_2018_113 Stappers, M.H.T.; Clark, A.E.; Aimanianda, V.; Bidula, S.; Reid, D.M.; Asamaphan, P.; Hardison, S.E.; et al. "Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus". Nature 555 7696 (2018): 382-386. 10.1038/nature25974 Gaifem, J.; Gonçalves, L.G.; Dinis-Oliveira, R.J.; Cunha, C.; Carvalho, A.; Torrado, E.; Rodrigues, F.; et al. 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American Journal of Respiratory and Critical Care Medicine 188 11 (2013): 1338-1350. 10.1164/rccm.201305-0986OC De Luca, Antonella; Carvalho, Agostinho; Cunha, Cristina; Iannitti, Rossana G.; Pitzurra, Lucia; Giovannini, Gloria; Mencacci, Antonella; et al. "IL-22 and IDO1 Affect Immunity and Tolerance to Murine and Human Vaginal Candidiasis". Plos Pathogens 9 7 (2013): e1003486. 10.1371/journal.ppat.1003486 Iannitti, Rossana G.; Carvalho, Agostinho; Cunha, Cristina; De Luca, Antonella; Giovannini, Gloria; Casagrande, Andrea; Zelante, Teresa; et al. "Th17/Treg Imbalance in Murine Cystic Fibrosis Is Linked to Indoleamine 2,3-Dioxygenase Deficiency but Corrected by Kynurenines". American Journal of Respiratory and Critical Care Medicine 187 6 (2013): 609-620. 10.1164/rccm.201207-1346OC Menino, Joao Filipe; Saraiva, Margarida; Gomes-Alves, Ana G; Lobo-Silva, Diogo; Sturme, Mark; Gomes-Rezende, Jessica; Saraiva, Ana Laura; et al. 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Frontiers in Microbiology 3 (2012): 176. 10.3389/fmicb.2012.00176 Carvalho, Agostinho; Cunha, Cristina; Bozza, Silvia; Moretti, Silvia; Massi-Benedetti, Cristina; Bistoni, Francesco; Aversa, Franco; Romani, Luigina. "Immunity and tolerance to fungi in hematopoietic transplantation: principles and perspectives.". Frontiers in immunology 3 (2012): 156-156. 10.3389/fimmu.2012.00156 Carvalho, A.; Cunha, C.; Bistoni, F.; Romani, L.. "Immunotherapy of aspergillosis". Clinical Microbiology and Infection 18 2 (2012): 120-125. 10.1111/j.1469-0691.2011.03681.x Carvalho, Agostinho; Cunha, Cristina; Iannitti, Rossana G.; De Luca, Antonella; Giovannini, Gloria; Bistoni, Francesco; Romani, Luigina; et al. "Inflammation in aspergillosis: the good, the bad, and the therapeutic". Annals of the New York Academy of Sciences 1273 (2012): 52-59. 10.1111/j.1749-6632.2012.06754.x Cunha, C; Rodrigues, F; Zelante, T; Aversa, F; Romani, L; Carvalho, A. 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Other

Other output

MAVS expression in alveolar macrophages is essential for host resistance against Aspergillus fumigatus. 2021. Wang, X.; Cunha, C.; Grau, M.S.; Robertson, S.J.; Lacerda, J.F.; Campos, A.; Lagrou, K.; et al.
10.1101/2021.08.07.21261611
Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections. 2019. Schmidt, F.; Thywißen, A.; Röcker, M.; Cunha, C.; Cseresnyés, Z.; Schmidt, H.; Galiani, S.; et al.
10.1101/606939
Paracoccin overexpression in Paracoccidioides brasiliensis reveals the influence of chitin hydrolysis on fungal virulence and host immune response. 2019. Gonçales, R.A.; Silva Vieira, V.C.; Ricci-Azevedo, R.; Fernandes, F.F.; de Oliveira Thomaz, S.M.; Carvalho, A.; Vendruscolo, P.E.; et al.
10.1101/515056

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2022/05	Metabolic control of immune cell function during fungal infection	FEBS Advanced Lecture Course HFP2022: “Molecular Mechanisms of Host-Pathogen Interactions and Virulence in Human Fungal Pathogens” Federation of European Biochemical Societies (La-Colle-sur-Loup, France)
2022/04	Role of pathogen and host pathophysiology in fungal diagnosis	32nd European Congress of Clinical Microbiology and Infectious Diseases European Society of Clinical Microbiology and Infectious Diseases (Lisbon, Portugal)
2021/06	Toward new insights into the role of the lung microbiota in invasive pulmonary aspergillosis	Mycology 2021 British Society for Medical Mycology (London, United Kingdom)
2021/06	Calcium sequestration by fungal melanin reprograms macrophage metabolism toward glycolysis and antifungal immunity	Mycology 2021 British Society for Medical Mycology (London, United Kingdom)
2020/02	Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity	9th Advances Against Aspergillosis and Mucormycosis (Lugano, Switzerland)
2019/10	Metabolic regulation of innate immunity to Aspergillus fumigatus	9th Trends in Medical Mycology (Nice, France)
2019/06	Diagnosis of aspergillosis based on metabolomics data - application of relative expression analysis-RXA to minimize interindividual metabolic differences	Metabolomics 2019 - 15th Annual Conference of the Metabolomics Society (The Hague, Netherlands)
2018/11	Regulação da inflamação na sarcoidose pela pentraxina-3 (PTX3)	XXXIV Congresso de Pneumologia (Albufeira, Portugal)
2018/10	Translating the host-microbiota interaction into risk assessment of fungal diseases	Mérieux Research Grant Meeting 2018 (Annecy, France)
2018/10	Inhibition of host neuraminidase increases susceptibility to invasive pulmonary aspergillosis	IDWeek 2018 (Washington, United States)
2018/09	The long pentraxin-3 restrains inflammation in sarcoidosis by regulating leukocyte recruitment and granuloma formation	Symposium 'New Frontiers in Innate Immunity and Inflammation' (Cluj-Napoca, Romania)
2018/07	New insights in diagnosis and immunopathology of aspergillosis	20th Congress of the International Society for Human and Animal Mycology (ISHAM) (Amsterdam, Netherlands)
2017/10	Translating the host-microbiota interaction into risk assessment of fungal diseases	Mérieux Research Grant Meeting 2017 (Annecy, France)
2017/10	The microbiome-metabolome crosstalk in the pathogenesis of invasive aspergillosis	8th Trends in Medical Mycology (TIMM) (Belgrade, Serbia)
2017/06	Inflammasome-mediated regulation of antifungal immunity in hematological patients	22nd European Hematology Association (EHA) Meeting (Madrid, Spain)
2014/02	Functional aspects of IA-linked genetic variants	6th Advances Against Aspergillosis (Madrid, Spain)
2013/08	Immunity and tolerance to fungi: the contribution of gut microbiota via tryptophan catabolism	15th International Congress of Immunology (ICI) (Milan, Italy)
2012/11	Genomica funzionale della aspergillosi	XI Congresso Nazionale FIMUA (Catania, Italy)
2012/05	Immunogenetics of aspergillosis: towards improved diagnosis and therapy	ESF Workshop “Omics and Aspergillosis: Past and Future” (Deshaies/Guadeloupe, France)
2011/04	Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity	37th Annual Meeting of the European Group for Blood and Marrow Transplantation (Paris, France)
2010/09	Immunity and tolerance to fungal infections in experimental HSCT: discriminating donor’s vs. host’s cellular and molecular pathways	6th Symposium on Haploidentical Stem Cell Transplantation (Jerusalem, Israel)
2010	Genetic susceptibility to aspergillosis in allogeneic stem cell transplantation	4th Advances Against Aspergillosis (Rome, Italy)
2009/11	Polymorphisms in immune genes and susceptibility to infections in allogeneic stem cell transplantation	EBMT Immunobiology Working Party Meeting 2009 (Perugia, Italy)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024 - Current	Dissecting the role of interleukin-37 in the metabolic regulation of antifungal immunity Supervisor of Inês Caldeira	PhD in Health Sciences (PhD) Universidade do Minho Escola de Medicina, Portugal
2024 - Current	Metabolic regulation of granulomatous inflammation by tryptophan catabolism Co-supervisor of Marcela Oliveira	PhD in Health Sciences (PhD) Universidade do Minho Escola de Medicina, Portugal
2024 - Current	Unravelling the role of galectin-3 in the regulation of antifungal immunity in viral-fungal co-infections Co-supervisor of Inês Pereira	PhD in Health Sciences (PhD) Universidade do Minho Escola de Medicina, Portugal
2023 - Current	Metabolic circuits of immune regulation and function during fungal infection Co-supervisor of Raquel Fernandes	PhD in Health Sciences (PhD) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - Current	Immunoregulatory role of c-Met in pulmonary fibrosis progression Supervisor of Catarina Matos	PhD in Health Sciences (PhD) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2022 - 2023	Dissecting itaconate-mediated mechanisms of anti-fungal activity in invasive pulmonary aspergillosis Supervisor of Inês Caldeira	Research Assistant (Other) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021 - 2023	The role of host lipid metabolism in the regulation of antifungal immunity Supervisor of Adrian Barnutiu	MSc in Biotechnology in Health Sciences (Master) Universidade de Trás-os-Montes e Alto Douro, Portugal
2018 - 2023	Metabolic regulation of antifungal immunity: from basic mechanisms to clinical translation Co-supervisor of Samuel Gonçalves	PhD in Health Sciences (PhD) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018 - 2023	Innate regulation of antifungal immunity in chronic pulmonary aspergillosis Co-supervisor of Cláudio Oliveira	PhD in Health Sciences (PhD) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018 - 2023	Macrophage's secretome: a novel therapeutic strategy for lung maturation and repair Supervisor of Caroline Pereira	Phd in Applied Health Sciences (PhDiHES) (PhD) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2022 - 2022	The host-microbiota interaction in fungal diseases: towards biomarker discovery and therapy Supervisor of Joana Rocha	Post-doctoral Researcher (Other) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021 - 2022	Innate regulation of inflammation in sarcoidosis Co-supervisor of Raquel Fernandes	Research Assistant (Other) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2022	Innate regulation of inflammation in sarcoidosis Co-supervisor of Relber Gonçales	Post-doctoral Researcher (Other) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021 - 2021	O papel imunometabólico da homeostasia do colesterol na resposta à infeção pelo fungo Aspergillus fumigatus Supervisor of Rui Pereira	BSc in Applied Biology (Degree) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021 - 2021	O papel do itaconato na resposta à infeção por Aspergillus fumigatus Supervisor of Ana Santos	BSc in Applied Biology (Degree) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021 - 2021	Dissecting itaconate-mediated mechanisms of anti-fungal activity in invasive pulmonary aspergillosis Supervisor of Tânia Pinheiro	Research Assistant (Other) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020 - 2021	Innate regulation of inflammation in sarcoidosis Co-supervisor of Sara Ferreira	Research Assistant (Other) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020 - 2021	The host-microbiota interaction in fungal diseases: towards biomarker discovery and therapy Supervisor of Carolina Pereira	Research Assistant (Other) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2021	Immunometabolic regulation of antifungal immunity by itaconate Co-supervisor of Carolina Pereira	MSc in Health Sciences (Master) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2021	HIF-1a-mediated regulation of antifungal immunity in chronic pulmonary obstructive disease Co-supervisor of Sara Ferreira	MSc in Health Sciences (Master) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2021	The host-microbiota interaction in fungal diseases: towards biomarker discovery and therapy Supervisor of Anais Hérivaux	Post-doctoral Researcher (Other) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020 - 2020	Metabolic regulation of immune function during fungal infection Supervisor of Adrian Barnutiu	BSc in Applied Biology (Degree) Universidade do Minho Escola de Ciências, Portugal
2018 - 2019	Genetic variation in pentraxin-3 and susceptitiblity to cytomegalovirus reactivation Co-supervisor of Francisco Silva	Integrated MSc in Medicine (Master) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018 - 2018	Regulation of antifungal immunity by the transcription factor HIF-1a Co-supervisor of Cátia Gomes	BSc in Applied Biology (Degree) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018 - 2018	The role of cholesterol in the immunometabolic response to infection Co-supervisor of Carolina Pereira	BSc in Applied Biology (Degree) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018 - 2018	Evaluation of the mechanisms of regulation of inflammation in sarcoidosis Co-supervisor of Luisa Carvalho	BSc in Biochemistry (Degree) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2018	Immunometabolic control of antifungal innate immunity Supervisor of Cláudia Rodrigues	MSc in Health Sciences (Master) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2018	Innate regulation of granulomatous inflammation in sarcoidosis Co-supervisor of Cláudia Campos	MSc in Health Sciences (Master) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2018	Sporothrix brasiliensis: from the genome to the phenotype Co-supervisor of Beatriz Ferreira	MSc in Health Sciences (Master) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016 - 2017	Translating the host-microbiota interaction into risk assessment of invasive aspergillosis Supervisor of Samuel Gonçalves	MSc in Health Sciences (Master) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016 - 2017	Trichosporonosis: from the pathogen to the disease Supervisor of Cláudio Oliveira	MSc in Health Sciences (Master) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016 - 2016	The contribution of PTX3 to the human immune response to Trichosporon spp. Supervisor of Cláudia Campos	BSc in Biochemistry (Degree) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016 - 2016	The immunometabolic profile of human macrophages during infection with the fungus Aspergillus fumigatus Co-supervisor of Cláudia Rodrigues	BSc in Applied Biology (Degree) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016 - 2016	The role of IL-10 overexpression in antifungal immunity Co-supervisor of Liliana Ferreira	BSc in Biochemistry (Degree) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015 - 2015	The role of inflammasome activation in the immune response to infection Supervisor of Samuel Gonçalves	BSc in Applied Biology (Degree) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015 - 2015	The role of autophagy in the immune response to infection Co-supervisor of Tânia Pinheiro	BSc in Applied Biology (Degree) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2014 - Current	Postgraduation Course "Autophagy in Health and Disease: Conceptual and Methodological Advances" (2015/04/07 - 2015/04/10) Other (Member of the Organising Committee)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2021	Genetic determinants of malaria therapeutics cross resistance with novel compounds (Thesis) Arguer	Carla Calçada (PhD) Universidade do Minho Escola de Medicina, Portugal
2019	Elaboração e implementação de um plano de higienização a uma unidade fabril e revisão da documentação associada (Thesis) Main arguer	Maria Inês Queirós (Master) Universidade do Minho Centro de Engenharia Biológica, Portugal
2018	Immunometabolic control of antifungal innate immunity Supervisor	Cláudia Rodrigues (Master) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017	Translating the host-microbiota interaction into risk assessment of invasive aspergillosis Supervisor	Samuel Gonçalves (Master) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017	Trichosporonosis: from the pathogen to the disease Supervisor	Cláudio Oliveira (Master) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016	The role of LKB1-AMPK pathway on acute myeloid leukemia (Thesis) Arguer	Ângela Fernandes (PhD) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Association member

	Society Organization name	Role
2017 - Current	Portuguese Society for Immunology	Member
2014 - Current	European Society of Clinical Microbiology and Infectious Diseases	Member
2007 - Current	Portuguese Society of Biochemistry	Member

Committee member

	Activity description Role	Institution / Organization
2014 - Current	Scientific Council of ICVS, University of Minho Member	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2014 - Current	Fundamentals of Immunology and Infection	(Pós-Graduação)	Universidade do Minho Escola de Medicina, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2023 - 2023	MRC Clinical Research Training Fellowship Evaluator	Medical Research Council, United Kingdom	Medical Research Council

Distinctions

Award

2023	SPI Best Paper Award 2023 Sociedade Portuguesa de Imunologia, Portugal
2022	Honorable Mention at the Maratona da Saúde Prize 2022 - Infectious Diseases Research FCT and the Maratona da Saúde Associação (MdS), Portugal
2021	Gilead Research Scholars - Antifungals Gilead Sciences Europe Ltd, United Kingdom
2017	HPF2017 Award at the HFP2017 Advanced Lecture Course 'Molecular Mechanisms of Host-Pathogens Interactions and Virulence in Human Fungal Pathogens' Journal of Fungi, Switzerland
2016	Prémio Robalo Cordeiro SPP/Novartis 2016 Sociedade Portuguesa de Pneumologia, Portugal
2015	ICVS Incentive to Research Award 2015 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012	ALLFUN Young Investigator Award European Commission Seventh Framework Programme for Research and Technological Development, Belgium
2012	ESID 2012 Award at the 15th Biennial Meeting of the European Society for Immunodeficiencies European Society for Immunodeficiencies, Netherlands
2011	Young Investigator Award at the 4th FEBS Advanced Lecture Course “Human Fungal Pathogens: Molecular Mechanisms of Host-Pathogen Interactions and Virulence” Federation of European Biochemical Societies, United Kingdom
2011	Jon J van Rood Award European Group for Blood and Marrow Transplantation Leiden, Netherlands
2008	Award for Best Contribution to the field of Genomics, Proteomics, Cellular Biology and Molecular Biology Asociación Colombiana de Microbiología, Colombia
2007	Young Investigator Award at the 2nd FEBS Advanced Lecture Course “Human Fungal Pathogens: Molecular Mechanisms of Host-Pathogen Interactions and Virulence” Federation of European Biochemical Societies, United Kingdom