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Vera Neves holds a PhD degree in Bionanotechnology, from University of Surrey, UK, obtained as part of a Marie Curie fellowship. Currently, she is a Staff Scientist (Research Assistant level) at iMM and an Invited assistant professor at Lisbon School of Medicine. Vera Neves has more than 15 years¿ experience in translational research, focusing on the delivery of therapeutics across the blood-brain barrier (BBB) for the treatment and diagnosis of brain diseases. At the Physical Biochemistry of Drugs & Targets Lab led by Prof. Miguel Castanho, Dr. Neves is responsible for a specific line of research and was the first to establish the in vitro models of the BBB (2D); to discover new BBB peptide shuttle; and supervised the work for the development of breast cancer (BC) spheroids and BC therapeutics. Dr. Neves has international experience, she has worked in both industrial (Biopeptides Corp., USA and TechnoPhage) and academia (University of Surrey, UK and iMM) environments and has engaged in research visits to different institutes (in Poland, Spain, Hungary, USA). Dr. Neves has coordinated five projects related to BBB crossing (total of 1,234,846.01¿), having 38 high-impact publications (9 as corresponding author) and 4 international patents (H-index of 17). Dr. Neves manages a team of six researchers (post-doctoral researchers, PhD students, MSc researcher and students). She collaborates with different national and international groups, including Dr. Ramos-Cabrer from CIC biomaGUNE, Spain with expertise in preclinical imaging in vivo; and Dr. Deli from Biological Research Centre, Hungary, with expertise in BBB models. Keywords: drug delivery systems, blood-brain barrier, peptides, neurotherapies, and nanomedicine.
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Identification

Personal identification

Full name
Vera Neves

Citation names

  • Neves, Vera

Author identifiers

Ciência ID
671C-1860-A160
ORCID iD
0000-0002-2989-7208
Google Scholar ID
https://scholar.google.pt/citations?hl=en&user=R_cciXIAAAAJ&view_op=list_works&gmla=AJsN-F5wwYFaAZznL84T8FcHytBg9jtPnpwK6vXYprEf5knQDJpi1SQWBl7NNm64DvF4i3ZvBTM1QXl9wsSBqtyPqMRV5pexvlJlrCSNQteWQqYJ-Q_gn68

Telephones

Telephone
  • 217985136 Ext.: 47256 (Professional)

Addresses

  • Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz, Edifício Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Advanced (C1)
Education
Degree Classification
2017/06 - 2017/06
Concluded
 iMM MasterClass in Fundamentals of Innovation and Tech Transfer (Outros)
Instituto de Medicina Molecular, Portugal
2016/06 - 2016/06
Concluded
 Leadership and Management skills course for scientists. (Outros)
hfp consulting, Germany
2013/05 - 2013/06
Concluded
 Laboratory animal science accreditation (Outros)
Instituto de Medicina Molecular, Portugal
2007/04/01 - 2011/02/06
Concluded
 Bionanotechnology (Doutoramento)
Major in nanomedicine
University of Surrey, United Kingdom
"Carbon nanotubes: Feasibility as nano-bio agents to target cancer" (THESIS/DISSERTATION)
1999/09/15 - 2004/12/09
Concluded
 Biotechnology engineering (Licenciatura)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
"Physiological aspects of yeast Debaryomyces hansenii" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2022/10/01 - Current Auxiliary Researcher (Research) Instituto de Medicina Molecular, Portugal
2018/08/01 - 2022/09/30 Contracted Researcher (Research) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2014/09/01 - 2018/07/31 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2018/02/07 - 2018/07/06 Visiting Researcher (Research) ProteoDesign, Spain
2012/04/01 - 2014/02/28 Postdoc (Research) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2007/04/01 - 2011/02 Research Trainee (Research) University of Surrey, United Kingdom
2008/11/01 - 2009/02/01 Visiting Researcher (Research) Zachodniopomorski Uniwersytet Technologiczny Instytut Fizyki, Poland
2005/03/01 - 2006/10/31 Researcher (Research) Biopeptides corp, United States

Teaching in Higher Education

Category
Host institution 		Employer
2019/04/01 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2024/01/08 - Current Development of an organ-on-a-chip of triple-negative breast cancer metastases for drug screening (TNBC-BM model),
Centro de Tecnologia e Inovação (CTI) - iMM
Principal investigator
Instituto de Medicina Molecular, Portugal
 Instituto de Medicina Molecular
Ongoing
2024/01/02 - Current AVITHRAPID: Antiviral therapeutics for rapid response agaisnt pandemic infectious diseases.
101137192
Researcher
Instituto de Medicina Molecular, Portugal
 European Commission
Ongoing
2022/02/02 - Current Search-AnD-See - Towards the development of a nanoparticle for early diagnosis of Alzheimer¿s Disease, based on the reversible translocation of the blood brain barrier.
PTDC/BTM-MAT/2472/2021
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - Current MolNanoBone - A molecular and nano approach to target the RANK-TRAF6 interface for bone metastases treatment
PTDC/QUIOUT/3854/2021
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/12/15 - Current Breast-Brain-N-BBB - Protecting the brain from metastatic breast cancer
HR21-00605
Researcher
Instituto de Medicina Molecular, Portugal
 Obra Social La Caixa
2021 - Current TRESPASS2TREAT - A novel approach in pharmacotherapies for breast cancer patients with brain metastasis.
PTDC/BIA-BQM/5027/2020
Researcher
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/09/01 - Current ''One size fits all'' unique drug to eradicate multiple viral species simultaneously from the central nervous system of co-infected individuals
828774
Researcher
Instituto de Medicina Molecular, Portugal
 European Commission
Ongoing
2020/11/01 - 2023/10/31 Epiepinet: Epileptogenesis and epilepsy network: from genes, synapses and circuits to pave the way for novel drugs and strategies
952455
952455
Researcher
Instituto de Medicina Molecular, Portugal
 EU Framework Programme for Research and Innovation Euratom
Ongoing
2019/04/01 - 2022/12/31 Development of a blood-brain barrier shuttle platform for applicability in Alzheimer's disease
FCT/NKFIH, 2019/2020
Researcher
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/10/01 - 2021/12/31 Selecting anti-Zika virus drug leads able to translocate the blood-placental and blood-brain barriers. Combining innovative and effective translocating peptides with new antivirals to target Zika across barriers.
PTDC/BIA-VIR/29495/2017
Principal investigator
Instituto de Medicina Molecular, Portugal

Universitat Pompeu Fabra - Campus de la Comunicació Poblenou, Spain

Universidade Federal do Rio de Janeiro, Brazil
Fundação para a Ciência e a Tecnologia
Ongoing
2018/06/14 - 2021/06/13 Development of a novel class of antibody-drug conjugates molecules for cancer treatment
PTDC/BTM-SAL/32085/2017
PI of participating institution (iMM)
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2021 Fighting Zika virus with antiviral peptides and conjugates translocating blood-placental and blood-brain barriers
HR17-00409
Researcher
Obra Social La Caixa
Ongoing
2016/05 - 2020/02/29 TRANSDRUG - Peptides for Blood-brain barrier transmigration and drug delivery
PTDC/BBBNAN/ 1578/2014
Principal investigator
Fundação para a Ciência e a Tecnologia
2016/05 - 2019/10/31 Alzheimer3D: Trifunctional Conjugates for the Selective Drug Delivery in Alzheimer’s Disease
PTDC/QEQMED/ 5512/2014
PI of participating institution (iMM)
Fundação para a Ciência e a Tecnologia
2016/05/01 - 2019/08/31 Overcoming the Brain Drug Delivery Bottleneck: Development of single domain antibodies for brain targeting and drug delivery across the Blood-Brain Barrier.
PTDC/BBB-BIO/0508/2014
PI of participating institution (iMM)
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Instituto de Medicina Molecular, Portugal

Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/02/01 - 2019/01/31 INPACT- Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training, and communication
644167
Researcher
Instituto de Medicina Molecular, Portugal
Concluded
2016/01/01 - 2017/01/31 Development of a new immunoliposome drug delivery system for treatment of pneumococcal meningitis
UID/CVT/00276/2013
Researcher
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
Concluded
2007/04/01 - 2011/02/06 Multifunctional carbon nanotubes for biomedical applications
MRTN-CT-2006-035616
MRTN-CT-2006-035616
PhD Student Fellow
University of Surrey, United Kingdom
 N/A
Concluded

Contract

Designation Funders
2023/02/01 - Current Innovative diagnostic tool to overcome the blood-brain barrier to blood-detection of early stages of Alzheimer disease
2022.11370.BD
Supervisor
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/10/01 - Current Diagnostic tool for Alzheimer’s disease based on a proprietary blood-brain barrier peptide shuttle-nanoparticle
2021.00895.CEECIND
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/10/01 - Current Multifunctional magnetic nanoparticles for targeted Alzheimer Disease theranostics
SFRH/BD/148588/2019
Supervisor
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/03/01 - 2025/02/28 Anticancer activity of a minibody against triple negative breast cancer brain metastases
UI/BD/151171/2021
Supervisor
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/05/01 - 2022/04 Kyotorphin as new pharmacological therapeutic strategy for Alzheimer’s Disease
PD/BD/114337/2016
Supervisor
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/01/01 - 2022/03/23 Trans-BBB peptides for targeting brain metastases
PD/BD/128281/2017
Supervisor
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2014/09/01 - 2018/07/31 Peptides for blood-brain barrier transmigration and drug delivery – novel therapies for the central nervous system (CNS).
SFRH/BPD/94466/2013
PTDC/BBB-NAN/1578/2014
Post-doc Fellow
Instituto de Medicina Molecular, Portugal

Centro de Ciências e Tecnologias Nucleares, Portugal

Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/04/01 - 2014/02/28 DoIT – desenvolvimento e operacionalização da investigação de translação (QREN). Secção D – PPS – sdAb+péptido- Investigação translacional em Alzeimer.
QREN
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Neves, V.; Coley, H. M.; McFadden, J.; Silva, S. R. P.. "Uptake, Intracellular Localization and Biodistribution of Carbon Nanotubes". In Carbon Nanotubes for Biomedical Applications, 169-182. Springer Berlin Heidelberg, 2011.
    10.1007/978-3-642-14802-6_9
  2. Heister, Elena; Neves, Vera; Silva, S. Ravi P.; McFadden, Johnjoe; Coley, Helen M.. "Carbon Nanotubes Loaded with Anticancer Drugs: A Platform for Multimodal Cancer Treatment". In Carbon Nanotubes for Biomedical Applications, 223-245. Springer Berlin Heidelberg, 2011.
    10.1007/978-3-642-14802-6_12
Conference poster
  1. O. Alarcão, Rodrigo; Neves, Vera; Sebastião, AM. Corresponding author: O. Alarcão, Rodrigo. "Characterizing the effects of psychedelics and polydrug abuse on the blood-brain barrier properties". Paper presented in ECNP Workshop Neuropsychopharmacology 24', 2024.
  2. Martins, Sofia A.; Rosa, Cátia; Cavaco, Marco; Melo, Rita; Andreu, David; Valle, Javier; Neves, Vera; Castanho, Miguel A. R. B.; Correia, João D. G.. "Bone-Seeking Peptides Targeting the RANK-TRAF6 Interface for Bone Metastases Theranostics". Paper presented in XVIII Iberian Peptide Meeting, 2023.
  3. Simões, Beatriz T.; Chaparro, Catarina I. P.; Castanho, Miguel; Ramos-Cabrer, Pedro; Paula I. P. Soares; Neves, Vera. Corresponding author: Simões, Beatriz T.. "Nanoparticles as a drug delivery system of therapeutics for brain diseases". Paper presented in Spanish & Portuguese Advanced Optical Microscopy Meeting, 2023.
  4. O. Alarcão, Rodrigo; Neves, Vera; Sebastião, AM. Corresponding author: O. Alarcão, Rodrigo. "Impact of psychoactive drugs on the blood-brain barrier properties". Paper presented in 36th ECNP Congress, 2023.
  5. Simões, Beatriz T.; Chaparro, Catarina I. P.; Cavaco, Marco; Castanho, Miguel; Ramos-Cabrer, Pedro; Paula I. P. Soares; Neves, Vera. "Development of a nanoparticle for early diagnosis of Alzheimer's disease". Paper presented in 33rd European Society of Biomaterials Conference, Davos, Switzerland, 2023.
  6. Neves, Vera. Corresponding author: Neves, Vera. "Blood-brain barrier peptide shuttles to improve therapeutics action in the central nervous system.". Paper presented in 28th American Peptide Symposium - APS2023, 2023.
  7. Neves, Vera. Corresponding author: Neves, Vera. "Peptide shuttles to assist the transport of therapeutics across the blood-brain barrier". Paper presented in Cerebral Vascular Biology Meeting - 14th international meeting, 2023.
  8. Anikó Szecskó; Mária Mészáros; Gergo Porkoláb; Neves, Vera; Cavaco, Marco; Simões, Beatriz T.; Chaparro, Catarina I. P.; et al. Corresponding author: Anikó Szecskó. "Investigation of viral peph3 peptide-functionalized nanoparticles on a culture model of the blood-brain barrier". Paper presented in Hungarian Neuroscience Doctoral Conference, 2023.
  9. O. Alarcão, Rodrigo; Neves, Vera; Sebastião, AM. "Impact of psychostimulants and alcohol on the blood-brain barrier properties". Paper presented in Epileptogenesis and Epilepsy Network: from genes, synapses and circuitries to pave the way for novel drugs and strategies (EpiEpiNet), 2022.
  10. Neves, Vera. Corresponding author: Neves, Vera. "DPepH3, an Improved Peptide Shuttle for Receptor-independent Transport across the Blood-Brain Barrier.". Paper presented in 36th European Peptide Symposium and 12th International Peptide Symposium., 2022.
  11. Neves, Vera. Corresponding author: Neves, Vera. "Design of biologicals for blood-brain barrier crossing.". Paper presented in IUBMB-FEBS-PABMB 2022 Congress, 2022.
  12. Neves, Vera. Corresponding author: Neves, Vera. "Development of a Blood Brain Barrier Peptide Shuttle and its conjugation to an Fc domain for brain delivery of therapeutic biomolecules". Paper presented in XXI National Congress of Biochemistry “Tunning Biochemistry with Life and Society”, 2021.
  13. Neves, Vera. Corresponding author: Neves, Vera. "Dual-active Peptides for the Treatment of Brain Metastases". Paper presented in 26th Annual Blood-Brain Barrier Consortium Meeting, 2021.
  14. Aguiar, Sandra I; Neves, Vera; Castanho, Miguel A. R. B.; Aires-da-Silva, Frederico. "Overcoming the BBB: in vivo selection of single domain antibodies for brain targeting and drug delivery". Paper presented in 11th Annual PEGS EUROPE, 2019.
  15. Neves, Vera; Aires-da-Silva, Frederico; Gano, Lurdes; Sofia Corte-Real; João D. G. Correia; Miguel Augusto Rico Botas Castanho. "Peptide delivery systems to overcome the Blood-Brain Barrier to treat brain diseases: focus on Alzeimers disease.". Paper presented in Controlled Release Society Annual Meeting & Exposition, 2019.
  16. Belo RF; Neves, Vera; Miguel Augusto Rico Botas Castanho; Maria José Diogenes. "The neuroprotective effect Amidated-Kyotorphin on Alzheimer’s Disease.". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, Lisbon, Portugal., 2019.
  17. Belo RF; Neves, Vera; Castanho, Miguel A.R.B.; Diógenes, MJ. "Amidated-Kyotorphin neuroprotective effect on Alzheimer’s Disease.". Paper presented in 14th International Conference on Alzheimer’s & Parkinson’s diseases, 2019.
  18. Marco Calvinho Cavaco; Miguel Augusto Rico Botas Castanho; Neves, Vera. "Overcoming the Blood-Brain barrier with peptide-conjugates.". Paper presented in EMBO Workshop: Current advances in protein translocation across membranes, Sant Feliu, Spain., 2019.
  19. Aguiar, Sandra I; Gaspar, Maria Manuela; André, Ana; Martins, Diana; Ferreira, Marta; Carvalheiro, Manuela; Neves, Vera; et al. "sdAb-immunoliposomes for brain targeting and drug delivery.". Paper presented in PEGS Europe, 2018.
  20. Neves, Vera; Aires-da-Silva, Frederico; Correia, J. D. G.; Castanho, Miguel A.R.B.. "Trans-Blood brain barrier peptides to enhace delivery of therapeutic molecules to treat Alzheimers disease.". Paper presented in 35th European Peptide Symposium, Dublin, Irland., 2018.
  21. Neves, Vera; Aires-da-Silva, Frederico; Morais, M.; Gano, M L; Miranda, H; Corte-Real, Sofia; Correia, J. D. G.; Castanho, Miguel A. R. B.. "Novel Peptide delivery systems for Blood brain barrier translocation with a focus on Alzheimers disease.". Paper presented in Barriers of the CNS - Gordon Research Conference, USA, 2018.
  22. Neves, Vera. "Novel peptides derived from Dengue virus capsid protein translocate reversibly the blood-brain barrier through a receptor-free mechanism.". Paper presented in 25th American Peptide Symposium, Whistler, BC, Canada., 2017.
Journal article
  1. Simões, Beatriz T.; Chaparro, Catarina I. P.; Vieira, Tânia; Cavaco, Marco; Neves, Vera; Silva, Jorge Carvalho; Borges, João; Almeida, Filipe; Paula I. P. Soares. Corresponding author: Paula I. P. Soares. "Inhibition of nanoparticles uptake by melanoma cells improves magnetic hyperthermia in vitro". Communications Biology, Springer Nature (2024):
    Submitted
  2. Marco Cavaco; Clara Pérez-Peinado; Javier Valle; Ruben D.M. Silva; Lurdes Gano; João D.G. Correia; David Andreu; Miguel A.R.B. Castanho; Vera Neves. "The use of a selective, nontoxic dual-acting peptide for breast cancer patients with brain metastasis". Biomedicine & Pharmacotherapy (2024): https://doi.org/10.1016/j.biopha.2024.116573.
    10.1016/j.biopha.2024.116573
  3. Chaparro, Catarina I. P.; Simões, Beatriz T.; Borges, João P.; Castanho, Miguel A. R. B.; Soares, Paula I. P.; Neves, Vera. "A Promising Approach: Magnetic Nanosystems for Alzheimer¿s Disease Theranostics". Pharmaceutics 15 9 (2023): 2316. http://dx.doi.org/10.3390/pharmaceutics15092316.
    Published • 10.3390/pharmaceutics15092316
  4. Dias, Susana A.; Pinto, Sandra N.; Silva-Herdade, Ana S.; Cavaco, Marco; Neves, Vera; Tavares, Luís; Oliveira, Manuela; et al. "Quantitative Imaging of the Action of vCPP2319, an Antimicrobial Peptide from a Viral Scaffold, against Staphylococcus aureus Biofilms of a Clinical Isolate". ACS Infectious Diseases 9 10 (2023): 1889-1900. http://dx.doi.org/10.1021/acsinfecdis.3c00195.
    Published • 10.1021/acsinfecdis.3c00195
  5. André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra I.; Leonardo, Ana; Nogueira, Sara; Amaral, Joana D.; Fernandes, Célia; et al. "Panobinostat-loaded folate targeted liposomes as a promising drug delivery system for treatment of canine B-cell lymphoma". Frontiers in Veterinary Science 10 (2023): http://dx.doi.org/10.3389/fvets.2023.1236136.
    10.3389/fvets.2023.1236136
  6. Zandona, Antonio; Madunic, Josip; Mi¿, Katarina; Marakovic, Nikola; Dubois-Geoffroy, Pierre; Cavaco, Marco; Mi¿etic, Petra; et al. "Biological response and cell death signaling pathways modulated by tetrahydroisoquinoline-based aldoximes in human cells". Toxicology (2023): 153588. http://dx.doi.org/10.1016/j.tox.2023.153588.
    10.1016/j.tox.2023.153588
  7. Ana S. André; Joana N. R. Dias; Sandra Aguiar; Sara Nogueira; Pedro Bule; Joana Inês Carvalho; João P. M. António; et al. "Rabbit derived VL single-domains as promising scaffolds to generate antibody–drug conjugates". Scientific Reports 13 1 (2023): http://dx.doi.org/10.1038/s41598-023-31568-x.
    10.1038/s41598-023-31568-x
  8. Bárbara B. Sousa; Cátia Rebelo de Almeida; Ana F. Barahona; Raquel Lopes; Ana Martins-Logrado; Marco Cavaco; Vera Neves; et al. "Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors". ACS Pharmacology & Translational Science (2022): https://doi.org/10.1021/acsptsci.2c00163.
    10.1021/acsptsci.2c00163
  9. Toni Todorovski; Diogo A. Mendonça; Lorena O. Fernandes-Siqueira; Christine Cruz-Oliveira; Giuseppina Guida; Javier Valle; Marco Cavaco; et al. "Targeting Zika Virus with New Brain- and Placenta-Crossing Peptide–Porphyrin Conjugates". Pharmaceutics 14 4 (2022): 738-738. https://doi.org/10.3390/pharmaceutics14040738.
    10.3390/pharmaceutics14040738
  10. Cavaco, Marco; Castanho, Miguel A. R. B.; Neves, Vera. "The Use of Antibody-Antibiotic Conjugates to Fight Bacterial Infections". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.835677.
    10.3389/fmicb.2022.835677
  11. Caccuri, Francesca; Neves, Vera; Gano, Lurdes; Correia, João D. G.; Oliveira, Maria Cristina Fialho; Mazzuca, Pietro; Caruso, Arnaldo ; Castanho, Miguel. "The HIV-1 Matrix Protein p17 Does Cross the Blood-Brain Barrier". Journal of Virology 96 1 (2022): http://dx.doi.org/10.1128/jvi.01200-21.
    10.1128/jvi.01200-21
  12. Fonseca-Gomes, João; Rodrigues, Tiago M; Vaz, Sandra H.; Ramalho, Rita M; Vicente Miranda, Hugo; Tanqueiro SR; de Almeida-Borlido, Carolina; et al. Corresponding author: Diógenes, MJ. "A Small TAT-TrkB Peptide Prevents BDNF Receptor Cleavage and Restores Synaptic Physiology in Alzheimer¿s Disease". in preparation (2022):
  13. Marco Cavaco; Silvia Frutos; Paula Oliete; Javier Valle; David Andreu; Miguel A. R. B. Castanho; Miquel Vila-Perelló; Vera Neves. "Conjugation of a Blood Brain Barrier Peptide Shuttle to an Fc Domain for Brain Delivery of Therapeutic Biomolecules". ACS Medicinal Chemistry Letters (2021): https://doi.org/10.1021/acsmedchemlett.1c00225.
    10.1021/acsmedchemlett.1c00225
  14. Filipa D. Oliveira; Marco Cavaco; Tiago N. Figueira; Javier Valle; Vera Neves; David Andreu; Diana Gaspar; Miguel A. R. B. Castanho. "The antimetastatic breast cancer activity of the viral protein-derived peptide vCPP2319 as revealed by cellular biomechanics". The FEBS Journal (2021): https://doi.org/10.1111/febs.16247.
    10.1111/febs.16247
  15. Marco Cavaco; Patrícia Fraga; Javier Valle; David Andreu; Miguel A. R. B. Castanho; Vera Neves. "Development of Breast Cancer Spheroids to Evaluate Cytotoxic Response to an Anticancer Peptide". Pharmaceutics (2021): https://doi.org/10.3390/pharmaceutics13111863.
    10.3390/pharmaceutics13111863
  16. Filipa D. Oliveira; Miguel A. R. B. Castanho; Vera Neves. "Exosomes and Brain Metastases: A Review on Their Role and Potential Applications". International Journal of Molecular Sciences 22 19 (2021): 10899-10899. https://doi.org/10.3390/ijms221910899.
    10.3390/ijms221910899
  17. Sandra Isabel Aguiar; Joana N. R. Dias; Ana André; Marta Lisete Silva; Diana Martins; Belmira Carrapiço; Miguel Castanho; et al. "Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening". Pharmaceutics (2021): https://www.mdpi.com/1999-4923/13/10/1598.
    10.3390/pharmaceutics13101598
  18. Diogo A. Mendonça; Mariët Bakker; Christine Cruz-Oliveira; Vera Neves; Maria Angeles Jiménez; Sira Defaus; Marco Cavaco; et al. "Penetrating the Blood-Brain Barrier with New Peptide–Porphyrin Conjugates Having anti-HIV Activity". Bioconjugate Chemistry (2021): https://doi.org/10.1021/acs.bioconjchem.1c00123.
    10.1021/acs.bioconjchem.1c00123
  19. Maria Gallo; Estefanía Moreno; Sira Defaus; Antonio Ortega-Alvaro; Angel Gonzalez; Patricia Robledo; Marco Cavaco; et al. "Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects". Journal of Medicinal Chemistry (2021): https://doi.org/10.1021/acs.jmedchem.1c00484.
    10.1021/acs.jmedchem.1c00484
  20. Ben Woods; Rúben D. M. Silva; Claudia Schmidt; Darren Wragg; Marco Cavaco; Vera Neves; Vera F. C. Ferreira; et al. "Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo". Bioconjugate Chemistry (2021): https://doi.org/10.1021/acs.bioconjchem.0c00659.
    10.1021/acs.bioconjchem.0c00659
  21. Marco Calvinho Cavaco; Clara Peinado; Javier Valle; Ruben Diogo Marques da Silva; João Domingos Galamba Correia; David Andreu Martinez; Miguel Augusto Rico Botas Castanho; Neves, Vera. "To What Extent Do Fluorophores Bias the Biological Activity of Peptides? A Practical Approach Using Membrane-Active Peptides as Models.". Frontiers in bioengineering and biotechnology (2020): https://europepmc.org/articles/PMC7509492.
    10.3389/fbioe.2020.552035
  22. Rita Belo; Margarida Martins; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, João; Neves, Vera; et al. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid ß Peptide-Induced Alzheimer's Disease Pathophysiology.". Frontiers in pharmacology (2020): https://europepmc.org/articles/PMC7363954.
    10.3389/fphar.2020.00985
  23. Marco Calvinho Cavaco; Javier Valle Garcia; Ruben Diogo Marques da Silva; João Domingos Galamba Correia; Miguel Augusto Rico Botas Castanho; David Andreu Martinez; Vera Luísa Santos Neves. "DPepH3, an Improved Peptide Shuttle for Receptor-independent Transport across the Blood-Brain Barrier". Current Pharmaceutical Design (2020): https://doi.org/10.2174/1381612826666200213094556.
    10.2174/1381612826666200213094556
  24. Cavaco, Marco; Gaspar, Diana; Neves, Vera; Castanho, Miguel A.. "The Effect of Different Fluorophores on Fluorescence-Based Techniques". Biophysical Journal 118 3 (2020): 153a. http://dx.doi.org/10.1016/j.bpj.2019.11.953.
    10.1016/j.bpj.2019.11.953
  25. Cavaco, Marco; Gaspar, Diana; ARB Castanho, Miguel; Neves, Vera. "Antibodies for the Treatment of Brain Metastases, a Dream or a Reality?". Pharmaceutics 12 1 (2020): 62. http://dx.doi.org/10.3390/pharmaceutics12010062.
    10.3390/pharmaceutics12010062
  26. Cavaco, Marco; Castanho, Miguel A. R. B.; Neves, Vera. "Peptibodies: An elegant solution for a long-standing problem". Peptide Science 110 1 (2018): e23095. http://dx.doi.org/10.1002/bip.23095.
    10.1002/bip.23095
  27. Neves-Coelho, Sara; Eleutério, Rute; Enguita, Francisco; Neves, Vera; Castanho, Miguel. "A New Noncanonical Anionic Peptide That Translocates a Cellular Blood–Brain Barrier Model". Molecules 22 10 (2017): 1753. http://dx.doi.org/10.3390/molecules22101753.
    10.3390/molecules22101753
  28. Neves, Vera; Aires-da-Silva, Frederico; Morais, Maurício; Gano, Lurdes; Ribeiro, Elisabete; Pinto, Antónia; Aguiar, Sandra; et al. "Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood–Brain Barrier through a Receptor-Free Mechanism". ACS Chemical Biology 12 5 (2017): 1257-1268. http://dx.doi.org/10.1021/acschembio.7b00087.
    10.1021/acschembio.7b00087
  29. Neves, V.; Aires-da-Silva, F.; Corte-Real, S.; Castanho, M.A.R.B.. "Antibody Approaches To Treat Brain Diseases". Trends in Biotechnology 34 1 (2016): 36-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955244848&partnerID=MN8TOARS.
    10.1016/j.tibtech.2015.10.005
  30. Neves, V; Heister, E; Costa, S; Tîlmaciu, C; Flahaut, E; Soula, B; Coley, H M; McFadden, J; Silva, S R P. "Design of double-walled carbon nanotubes for biomedical applications". Nanotechnology 23 36 (2012): 365102. http://dx.doi.org/10.1088/0957-4484/23/36/365102.
    10.1088/0957-4484/23/36/365102
  31. Neves, Vera; Gerondopoulos, Andreas; Heister, Elena; Tîlmaciu, Carmen; Flahaut, Emmanuel; Soula, B.; Silva, S. Ravi P.; McFadden, Johnjoe; Coley, Helen M.. "Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells". Nano Research 5 4 (2012): 223-234. http://dx.doi.org/10.1007/s12274-012-0202-9.
    10.1007/s12274-012-0202-9
  32. Heister, Elena; Neves, Vera; Lamprecht, Constanze; Silva, S.Ravi P.; Coley, Helen M.; McFadden, Johnjoe. "Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with carbon nanotubes". Carbon 50 2 (2012): 622-632. http://dx.doi.org/10.1016/j.carbon.2011.08.074.
    10.1016/j.carbon.2011.08.074
  33. del Rio, Beatriz; Fuente, Jesus Lajara; Neves, Vera; Dattwyler, Raymond; Seegers, Jos F.M.L.; Gomes-Solecki, Maria. "Platform technology to deliver prophylactic molecules orally: An example using the Class A select agent Yersinia pestis". Vaccine 28 41 (2010): 6714-6722. http://dx.doi.org/10.1016/j.vaccine.2010.07.084.
    10.1016/j.vaccine.2010.07.084
  34. Neves, Vera; Heister, Elena; Costa, Sara; Tîlmaciu, Carmen; Borowiak-Palen, Ewa; Giusca, Cristina E.; Flahaut, Emmanuel; et al. "Uptake and Release of Double-Walled Carbon Nanotubes by Mammalian Cells". Advanced Functional Materials 20 19 (2010): 3272-3279. http://dx.doi.org/10.1002/adfm.201000994.
    10.1002/adfm.201000994
  35. Heister, Elena; Lamprecht, Constanze; Neves, Vera; Tîlmaciu, Carmen; Datas, Lucien; Flahaut, Emmanuel; Soula, Brigitte; et al. "Higher Dispersion Efficacy of Functionalized Carbon Nanotubes in Chemical and Biological Environments". ACS Nano 4 5 (2010): 2615-2626. http://dx.doi.org/10.1021/nn100069k.
    10.1021/nn100069k
  36. Lamprecht, C; Liashkovich, I; Neves, V; Danzberger, J; Heister, E; Rangl, M; Coley, H M; et al. "AFM imaging of functionalized carbon nanotubes on biological membranes". Nanotechnology 20 43 (2009): 434001. http://dx.doi.org/10.1088/0957-4484/20/43/434001.
    10.1088/0957-4484/20/43/434001
  37. Ivanova, Larisa; Christova, Iva; Neves, Vera; Aroso, Miguel; Meirelles, Luciana; Brisson, Dustin; Gomes-Solecki, Maria. "Comprehensive seroprofiling of sixteen B. burgdorferi OspC: Implications for Lyme disease diagnostics design". Clinical Immunology 132 3 (2009): 393-400. http://dx.doi.org/10.1016/j.clim.2009.05.017.
    10.1016/j.clim.2009.05.017
  38. Heister, Elena; Neves, Vera; Tîlmaciu, Carmen; Lipert, Kamil; Beltrán, Vanesa Sanz; Coley, Helen M.; Silva, S. Ravi P.; McFadden, Johnjoe. "Triple functionalisation of single-walled carbon nanotubes with doxorubicin, a monoclonal antibody, and a fluorescent marker for targeted cancer therapy". Carbon 47 9 (2009): 2152-2160. http://dx.doi.org/10.1016/j.carbon.2009.03.057.
    10.1016/j.carbon.2009.03.057
  39. del Rio, B.; Dattwyler, R. J.; Aroso, M.; Neves, V.; Meirelles, L.; Seegers, J. F. M. L.; Gomes-Solecki, M.. "Oral Immunization with Recombinant Lactobacillus plantarum Induces a Protective Immune Response in Mice with Lyme Disease". Clinical and Vaccine Immunology 15 9 (2008): 1429-1435. http://dx.doi.org/10.1128/cvi.00169-08.
    10.1128/cvi.00169-08
  40. Del Rio, B.; Dattwyler, R.J.; Aroso, M.; Neves, V.; Meirelles, L.; Seegers, J.F.M.L.; Gomes-Solecki, M.. "Oral immunization with recombinant Lactobacillus plantarum induces a protective immune response in mice with lyme disease". Clinical and Vaccine Immunology 15 9 (2008): 1429-1435. http://www.scopus.com/inward/record.url?eid=2-s2.0-51649091939&partnerID=MN8TOARS.
    10.1128/CVI.00169-08

Intellectual property

Patent
  1. Cavaco, M; Neves, Vera; Castanho, Miguel A. R. B.. 2023. "Métodos para identificação de péptidos transportadores de barreira hematoencefálica".
    Pending
  2. ARB Castanho, Miguel. 2022. "ANTI-INFECTIVE CONJUGATE FOR USE IN THE TREATMENT OF ZIKA VIRUS INFECTION". Germany.
    Pending
  3. Casado, V.; Moreno, E.; Maldonado, R.; Andreu, D.; Gallo, M.; Castanho, M.; Neves, Vera; Cavaco, M.. 2019. "Peptide compounds for reducing side effects of CB1 receptor agonists".
    Pending
  4. Neves, Vera; Côrte-Real, Sofia; Neves, Vera; Oliveira, Soraia; Canhão, P; Outeiro, Tiago; Castanho, Miguel; Aires-da-Silva, Frederico. 2016. "Antibody molecules and peptide delivery systems for use in Alzheimer’s disease and related disorders". United States.
    Allowed
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11/28 Peptide Shuttles to improve therapeutic action in the central nervous system XVIII Iberian Peptide Meeting
Peptide society (Sesimbra, Portugal)
2023/01/26 Peptide shuttles for receptor independent transport across the BBB Symposium "Cell Based Research in Toxicology and Drug Design”
Institute for Medical Reserach and Occupational Health, Zagreb, Croatia (Zagreb, Croatia)
2022/06/10 Crossing Biological Barriers using Peptides. Institute visit
Wyss Institute (Boston, United States)
2021/10/16 Development of a Blood Brain Barrier Peptide Shuttle and its conjugation to an Fc domain for brain delivery of therapeutic biomolecules XXI National Congress of Biochemistry
(Évora)
2021/03/19 Peptide shuttles for receptor-independent transport across the BBB Models of the Blood-Brain Barrier Scientific Tools to Target the Brain
Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)
2018/02/06 Novel Peptide delivery systems for Blood brain barrier translocation with a focus on Alzheimer’s disease 16th Iberian peptide meeting
(Barcelona, Spain)
2017/11 Novel peptides derived from Dengue virus capsid protein translocate reversibly the blood-brain barrier through a receptor-free mechanism iMM annual PDA meeting
(Lisboa, Portugal)
2017/10 New cell-penetrating peptide for drug delivery to the brain. 5th Italian Experience in Biomedical Research: Young Minds at Work
(Lombardy, Italy)
2016/02/11 A novel peptide platform derived from Dengue virus for drug delivery into the brain EPI XV – Iberian peptide meeting
(Porto, Portugal)
2009/06/24 Carbon nanotubes: Interaction with cells for gene targeting NT09: Tenth International Conference on the Science and Application of Nanotubes
(Beijing , China)
2009/06/15 Carbon nanotubes: Interaction with cells for gene targeting 2nd ESF Summer School Nanomedicine
(Lisbon, Portugal)
2008/04/10 Carbon nanotubes: Delivery to cancer cells for gene targeting and therapy INNANO conference
(Innsbruck, Austria)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/10/01 - Current Identification and characterization of cancer stem cells in breast cancer biopsies and comparison with cancer cell lines
Supervisor
 Medicine (Degree)
Universidade de Lisboa Faculdade de Medicina, Portugal
2023/02/01 - Current Innovative diagnostic tool to overcome the blood-brain barrier to blood-detection of early stages of Alzheimer disease
Supervisor of Patricia Fraga
Instituto de Medicina Molecular, Portugal
2023/01/05 - Current 26.º Programa “Educação pela Ciência” / Bolsas CHLN/FMUL, project Development of a 3D Blood-Brain Barrier (BBB) Microfluidic model to assess transport of peptide-funcionalized Nanoparticles"
Supervisor of João Grancho
 Medicine (Degree)
Universidade de Lisboa Faculdade de Medicina, Portugal
2022/09/15 - Current Impact of psychostimulants and alcohol on the blood-brain barrier properties
Supervisor of Rodrigo Alarcão
 Mestrado em Neurociências (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/03/01 - Current Anticancer activity of a minibody against triple negative breast cancer brain metastases
Supervisor of Catarina Gonçalves
 Biochemistry (PhD)
Instituto de Medicina Molecular, Portugal
2019/10/01 - Current Multifunctional magnetic nanoparticles for targeted Alzheimer Disease theranostics
Co-supervisor of Catarina Isabel Parente Chaparro
 Nanotecnologias e Nanociências (PhD)
Universidade Nova de Lisboa Centro de Investigação em Materiais, Portugal

Instituto de Medicina Molecular, Portugal
2023/09/15 - 2024 Design of peptide-based inhibitors to tackle triple-negative breast cancer
Supervisor of Alexandra Afonso
 Biomedical research (Master)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2016/05/01 - 2022/04 Kyotorphin as new pharmacological therapeutic strategy for Alzheimer’s Disease
Co-supervisor of Rita Belo
 M2B PhD (Neurosciences) (PhD)
Instituto de Medicina Molecular, Portugal
2017/01/01 - 2022/03/23 Trans-BBB peptides for targeting brain metastases
Supervisor of Marco Cavaco
 LisbonBioMed program (PhD)
Instituto de Medicina Molecular, Portugal
2020/10/01 - 2021/11/12 Development of a brain metastasis co-culture cellular model for drug testing.
Supervisor of Patrícia Fraga
 Mestrado em Ciências Biofarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Instituto de Medicina Molecular, Portugal
2018 - 2019 Blood based biomarkers for Alzheimer’s disease – an in vitro proof of concept
Co-supervisor of Abeda Ahmad
 Biochemistry for health (Master)
Instituto de Medicina Molecular, Portugal
2015/01/01 - 2018/01/23 Kyotorphin and its derivatives: Unveiling routes and targets
Supervisor of Juliana Perazzo
LisbonBioMed program (PhD)
Instituto de Medicina Molecular, Portugal
2017 - 2018 Importância da utilização de péptidos com capacidade de transmigração da barreira hemato-encefálica em metástases no cérebro
Supervisor of Francisco António de Aguilar Baptista
 Medicina (Degree)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015/09/15 - 2017/01 Peptide optimization for specific delivery to the blood-brain barrier
Co-supervisor of Sara Neves Coelho
 Neurosciences (Master)
Instituto de Medicina Molecular, Portugal
2015 - 2016 Translocation mechanism of blood-brain barrier by peptides derived from Dengue virus - New drug delivery systems
Supervisor of Rute Eleuterio
Biochemistry (Master)
Universidade Nova de Lisboa Departamento de Química, Portugal
2015 - 2016 Development of a theranostic system for central nervous system based on superparamagnetic nanoparticles
Co-supervisor of Mariana Amaro
Biochemistry (Master)
Universidade Nova de Lisboa Departamento de Química, Portugal
2015 - 2015 Importância da Utilização de Péptidos com Capacidade de Transmigração da Barreira Hemato-Encefálica na Doença de Alzheimer
Supervisor of Inês Moita Ladeiras Coutinho dos Santos
 Medicine (Degree)
Universidade de Lisboa Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/09/27 - 2021/10/01 Summer School, part of the EpiEpiNet (Epileptogenesis and Epilepsy Network) Twinning Project, entitled "Trends and Challenges in Epilepsy Research", involving around 20-25 participants, the audience being mostly PhD students and post-docs from different countries. (2021/09/27 - 2021/10/01)
Symposium (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal
2018/06 - 2018/12 Conference on "Innovative approaches in targeted therapies: Brain, Infections and Cancer." as part of project RISE -INPACT - innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutic development, product market targeting, training and communication. (2018/12/13 - 2018/12/14)
Conference (Member of the Scientific Committee)
 Instituto de Medicina Molecular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/09/23 - 2022/09/24 EPILEPTOGENESIS AND EPILEPSY NETWORK: from genes, synapses, and circuitries to pave the way for novel drugs and strategies. EPIEPINET is a European Consortium funded by the European Union.
Symposium
 3rd Annual Meeting EPIEPINET
Instituto de Medicina Molecular, Portugal
2022/05/23 - 2022/05/26 EATRIS-Plus Summer School in Personalised Medicine
Symposium
 EATRIS-Plus Summer School in Personalised Medicine
Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2019/07/21 - 2019/07/24 Poster Presentation - Peptide delivery systems to overcome the Blood-Brain Barrier to treat brain diseases: focus on Alzeimers disease.
Congress
 Controlled Release Society Annual Meeting & Exposition
2019/03/26 - 2019/03/26 Workshop: The Promise and Pitfalls of Real-world evidence in Alzheimer’s Disease, part of 14th¿ International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders.
Conference
 14th¿ International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders
2018/08/26 - 2018/08/31 Poster presentartion: Trans-Blood brain barrier peptides to enhance delivery of therapeutic molecules to treat Alzheimer’s disease. (P153).
Conference
 35th European Peptide Symposium
2017/06/17 - 2017/06/22 Poster presentation: Novel peptides derived from Dengue virus capsid protein translocate reversibly the blood-brain barrier through a receptor-free
Conference
 25th American Peptide Symposium

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/11/27 Therapeutic application of Argonaute-2 to enhance neurovascular repair and inflammatory restitution in stroke
(Thesis) Arguer
 Marta Pereira (PhD)
Universidade da Beira Interior, Portugal
2023/02/17 Unravelling and modulating the interplay between breast cancer cells and blood-brain barrier endothelial cells: a new hope to prevent brain metastasis formation
(Thesis) Main arguer
 Ana Rita da Costa Garcia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/12/12 Development of lipid-polymer hybrid nanoparticles as a strategy to treat Alzheimer´s Disease
(Thesis) Main arguer
 Catarina Cachão Roque (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/11/19 In Silico design of novel peptides for treating cancer through inhibition of the RANK-TRAF6 interaction
(Thesis) Main arguer
 Sara Batalha Galhofo Celestino Perdigão (Master)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2018 From rabbit to men: Development of single domain antibodies against gp120 receptor of HIV
(Thesis) Main arguer
 Isabel Beatriz Fernandes Parreira (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/12/18 Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines
(Thesis) Main arguer
 Catarina Isabel Parente Chaparro (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2022 - Current Bioconjugate chemistry (1043-1802) ACS publications
2019 - Current Molecules MDPI
2019 - Current Pharmaceutics MDPI
2019 - Current Biomolecules MDPI
2017 - Current Nanomedicina: Nanotechnology, Biology, and Medicine (1549-9634) Elsevier

Association member

Society Organization name Role
2022/04/01 - Current National Cancer Hub Portugal, NCH-PT Participant
2019/04/29 - Current Controlled Release Society Member
2018/05/04 - Current Children’s Brain Tumour Drug Delivery Consortium (CBTDDC) Participant
2017/12/11 - Current European Peptide Society Member

Conference scientific committee

Conference name Conference host
2018/12/13 - 2018/12/14 Innovative approches in targeted therapies: Brain, Infections and Cancer Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/04/01 - Current Módulo II.1 do Mestrado Integrado em Medicina - aulas práticas de bioquímica Medicina (Licenciatura) Universidade de Lisboa Faculdade de Medicina, Portugal
2017/09 - Current Blood Brain barrier: Challenges to develop new therapeutic tools to act in the brain Neurosciences (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2017/01/31 - 2018/01/30 Lecturer - Blood Brain barrier: Challenges to develop new therapeutic tools to act in the brain LisbonBioMed Program (Doutoramento) Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2022/07/22 On World Brain Day, we advocate for health care, education, and research into neurological disorders. The theme for 2022 campaign is “our brain, our future”. Opinion article on "What are the challenges and progress in the development of drugs for the brain?" Activa magazine (Health)

Mentoring / Tutoring

Topic Student name
2018/12/20 - Current Role of non-psychoactive cannabinoids in neural stem cell differentiation: relevance for Neurodegenerative diseases Diogo Lourenço
2023/10/16 - 2023/12/15 Characterization of newly designed blood-brain barrier peptide shuttles Lucija Marcelic
2023/02/20 - 2023/06/09 Erasmus + "Traineeship biomedical laboratory technology specialization" Richa Guldentops
2023/02/06 - 2023/03/17 Visiting student - Assays to evaluate transport across the blood-brain barrier in vitro Albert Gator
2021/08 - 2021/09 Visiting student - EMBO Scientific Exchange Grant (number 8731) Antonio Zandona
2018/09 - 2018/12 Visiting PhD student from University Pompeu Fabra, Spain. Maria Gallo
2018/08 - 2018/08 Visiting student (undergraduate) from University of Surrey, UK. Rachel Mendes
2016 - 2017 Visiting PhD student from University of Brescia, Italy. Pietro Mazzuca
2009 - 2010 Effect of the mycobacterium cell entry protein MCE1a on facilitating siRNA delivery into prostate cells using carbon nanotube-based vectors Houmam Kafa

Other jury / evaluation

Activity description Institution / Organization
2021/07/28 - 2021/07/28 Provas do Curso de Doutoramento em Farmácia da Faculdade de Farmácia da Universidade de Lisboa, especialidade de Biologia Celular e Molecular, da doutoranda Joana Godinho Pereira Universidade de Lisboa Faculdade de Farmácia, Portugal
Distinctions

Award

2018 2nd Poster prize
European Peptide Society , Ireland
2010 AACR annual meeting in Washington
British Association for Cancer Research, United Kingdom
2009 Nanomedicine summer school
European Science Foundation, France