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Carla Cruz is an Associate Professor at Chemistry Department - Faculty of Sciences of University of Beira Interior (UBI). In 2017, she was awarded with a highly competitive FCT Investigator contract (IF/00959/2015) as Assistant Researcher. She is the GROUP LEADER of G4Lab (https://gquadruplex.wixsite.com/ccruz) at CICS-UBI, establishing her independent research line since 2015. Currently, her team has 1 post-doc, 6 PhD and 2 MSc students. During her scientific career, she supervised until completion 2 post-docs, 3 PhD, 30 MSc and 26 BSc students, plus 14 other students with research grants. She has also experience in committee members of PhD and MSc theses, as well as on committees for research fellowships under projects and for the acquisition of equipment. Her RESEARCH TOPIC is focused on drug design, development and delivery, as well as on the optimization of biophysical/cellular and molecular methods to study nucleic acids, including DNA/RNA G-quadruplex (G4) aptamers and protein targets towards cancer . This has been RECOGNIZED by the scientific community, having published more than 95 articles, 47 in the last 5 years, being the first and/or corresponding author in more than 80% of those papers, in addition to 2 patents and over 150 conference presentations, including 33 oral communications and more than 20 invited talks. She is/was the PRINCIPAL INVESTIGATOR of 15 national/international projects and a Member of 6 other funded projects (ICON_CENTRO-010145-FEDER-000013, NANOGLIO, PUREmiRSILs, CICS4COVID, CovidOUT, COMBINE). Since 2021, she is COORDINATOR of the Biopharmaceuticals and Biomaterials group at CICS-UBI, a Member of its Executive Board, Coordinator of PTNMR infrastructure integrated in European INSTRUCT-ERIC infrastruture at CICS-UBI (PINFRA/22161/2016) funded with 6.3 MEur, and Coordinator of the International PhD Program in NMR Applied to Chemistry, Materials and Biosciences (PD/00065/2013) at UBI. She belongs to the Management Committee of COST Action CA17140 (Nano2Clinic) and she is a Member of COST Action CA17013 (Delivery of Antisense RNA). She collaborated with several International Institutions all over the world, through published papers, funded projects and joint supervision of students with FCT grants, namely with MIT, Univ. Texas at Austin, Penn State College of Medicine, IECB-Univ. Bordeaux, Institut de Biologie Structurale Grenoble, Autonomous University of Madrid, Ecole Polytechnique Paris, Univ. Santiago de Compostela, Univ. Burgos, Univ. Ferrara, ETH Zurich, and Univ. Barcelona. She has also collaborated with the CRODA-UK and LABFIT companies and with the CHUCB and HUC hospitals, in additional to the following Portuguese Institutions: IPATIMUP, INESC-MN, IST-C2TN, REQUIMTE/LAQV Univ Aveiro, UCIBIO FCT NOVA, and CITAB-UTAD. She was a visiting scientist at Univ. Strasbourg (with Dr. S. Ladame), IECB-Univ. Bordeaux (with Dr. JL. Mergny and Dr. G. Salgado), Penn State College of Medicine (with Dr. Craig Meyers), Magnetic Resonance Center (with Dr. Marco Fragai) and National Centre for Biotechnology (with Dr. Leonor KREMER). Her outreach activities include being a speaker at Hospitals, Cancer Day, Science Week, newspapers, radio (Antena 1) and TV interviews. She was also the organizer of Advanced NMR courses at UBI.
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Identification

Personal identification

Full name
Carla Patrícia Alves Freire Madeira Cruz

Citation names

  • Cruz, Carla

Author identifiers

Ciência ID
6816-7888-F8B1
ORCID iD
0000-0001-6630-1242
Researcher Id
I-7806-2013
Scopus Author Id
7202701394

Email addresses

  • ccruz@ubi.pt (Professional)

Telephones

Mobile phone
  • 966861483 (Personal)
Telephone
  • 275329076 Ext.: 5076 (Professional)

Addresses

  • Av. Infante D. Henrique, 6200-506, Covilhã, Covilhã, Portugal (Professional)
  • Rua Belsol nº41, 6200-818, Tortosendo, Covilhã, Portugal (Personal)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2021/09/01 - 2023/08/31
Ongoing
 Assistant Researcher (Outros)
Major in UIDP/Multi/00709/2020
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/01/01 - 2021/08/31
Concluded
 Assistant Researcher FCT Investigator contract (IF/00959/2015) (Outros)
Major in FCT Investigator contract (IF/00959/2015)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/01/01 - 2016/12/31
Concluded
 Bioengineering and Biotechnology (Pós-doutoramento)
Major in SFRH/BPD/100015/2014
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2009/02/01 - 2016/12/31
Concluded
 Biochemistry and Biotechnology (Pós-doutoramento)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2009/01/15
Concluded
 Coordination and Supramolecular Chemistry (Doutoramento)
Major in Coordination and Supramolecular Chemistry
Universidade de Aveiro, Portugal
2000/12/07
Concluded
 Chemistry (Diploma de especialização)
Major in Master in Chemistry - Quality Control
Universidade de Coimbra, Portugal
1998/06/18
Concluded
 Chemistry (Licenciatura)
Universidade de Coimbra, Portugal
Affiliation

Science

Category
Host institution 		Employer
2017/01/01 - 2022/08/31 Auxiliary Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2022/04/01 - 2022/04/30 Visiting Researcher (Research) Institut Européen de Chimie et Biologie, France
2019/09/01 - 2019/12/15 Invited Principal Investigator (Research) Institut Européen de Chimie et Biologie, France
2019/05/13 - 2019/05/17 Visiting Researcher (Research) Centro de Ciências e Tecnologias Nucleares, Portugal
2018/08/01 - 2018/08/31 Visiting Researcher (Research) Penn State College of Medicine Department of Microbiology and Immunology, United States
2015/03/01 - 2015/03/31 Invited Principal Investigator (Research) Institut Européen de Chimie et Biologie, France
2013/01/05 - 2013/02/02 Visiting Researcher (Research) Institut Européen de Chimie et Biologie, France
2012/10/20 - 2012/10/24 Research Trainee (Research) Bruker BioSpin GmbH, Germany
2011/02/01 - 2011/04/30 Visiting Researcher (Research) Università degli Studi di Firenze Centro di Ricerca di Risonanze Magnetiche, Italy
2010/06/01 - 2010/09/30 Visiting Researcher (Research) Centro Nacional de Biotecnología, Spain
2010/02/02 - 2010/03/30 Visiting Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/09/15 - 2009/12/15 Visiting Researcher (Research) Centro Nacional de Biotecnología, Spain
2009/06/01 - 2009/06/30 Visiting Researcher (Research) Institut de Science et d'Ingénierie Supramoléculaires, France
2009/01/02 - 2009/04/30 Visiting Researcher (Research) Universidade Nova de Lisboa Departamento de Química, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2024/10/08 - Current Associate Professor (University Teacher) Universidade da Beira Interior Faculdade de Ciências, Portugal
2022/09/01 - 2024/10/07 Assistant Professor (University Teacher) Universidade da Beira Interior Faculdade de Ciências, Portugal
2010/03/01 - 2022/07/31 Invited Assistant Professor (University Teacher) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Positions / Appointments

Category
Host institution 		Employer
2021/11/10 - Current Organic Unit Director Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2016/01/02 - Current Coordinator of International PhD Program in NMR Applied to Chemistry, Materials and Biosciences. at UBI Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2012/01/02 - Current Coordinator of Portuguese Nuclear Magnetic Resonance Network at UBI Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2010/02/01 - Current Manager of Laboratory, Institute, Museum, Centre or Observatory Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Others

Category
Host institution 		Employer
2015/07/01 - Current Responsible Researcher for the internship developed under Scientific International Exchanges of Medical Students Associations (IFSMA) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/06/22 - Current Responsible researcher for the integrated internship on the program "Live Science in the Lab - Scientific Occupation of Young students in Holidays Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Grant

Designation Funders
2023/03/14 - Current PAPILOMA- ARRISCA C+
ARRISCA C+
Principal investigator
Fundo Europeu de Desenvolvimento Regional , Portugal
Ongoing
2022/11/01 - Current Novel approach to control let-7e miRNA biogenesis: Unveiling the relationship between structure and function of let-7e precursor miRNA/nucleolin complex
Instruct-ERIC Pilot R&D project call 2022
Principal investigator
Ongoing
2021 - Current BInov 2021 Award, Innovation Grant funded by the Southern and Autonomous Regions Regional Section (SRSRA) of the Order of Pharmacists
BInov 2021
Researcher
Ongoing
2023/02/01 - 2023/06/30 DEFEND - Vaginal gel for cancerous lesions caused by the Human Papilloma Virus
CENTRO-01-0246-FEDER-000044
Principal investigator
Fundo Europeu de Desenvolvimento Regional , Portugal
 Fundo Europeu de Desenvolvimento Regional
Ongoing
2020/11/01 - 2021/12/31 SENSE - Deteção de eStruturas de G-quadruplEx no SARS-CoV-2 utilizando soNdas fluorescentes
ref. 6- Principal Investigator
Principal investigator
Centro de Competências em Cloud Computing (C4)
Concluded
2015/02/01 - 2016/12/31 Purification, detection and stabilization of G-quadruplex for cancer therapy
SFRH/BPD/100015/2014
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2009/02/01 - 2015/01/31 Estudos de ligação entre oligonucleótidos e aminoácidos por ressonância de plasma de superfície e ressonância magnética nuclear
SFRH/BPD/46934/2008
Post-doc Fellow
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/10/01 - 2011/10/31 Structural analysis between amino acids affinity ligands and plasmid DNA pGL1 -FP7 BiO-NMR
-
Researcher
Università degli Studi di Firenze Centro di Ricerca di Risonanze Magnetiche, Italy
 European Commission Seventh Framework Programme for Research and Technological Development Health
Concluded
2009/07/22 - 2009/07/31 Short-Term Scientific Mission (STSM) COST -STSM-MP0802-05023
COST-STSM-MP0802-4788
Researcher
European Cooperation in Science and Technology, Belgium
Concluded
2004/10/01 - 2008/09/30 Estudo de receptores sintéticos no reconhecimento molecular de substratos aniónicos e iões metálicos
SFRH/BD/19266/2004
PhD Student Fellow
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2001/03/01 - 2004/09 Non-Symmetric Macrocycles for Metal Complexes and Supramolecular Aggregates with Pesticides
info:eu-repo/grantAgreement/FCT/POCI/35396/PT
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
2001/12/31 - 2003/12/31 Actividade contra Mycobacterium tuberculosis e complexo Mycobacterium avium
POCTI/ESP/35877/1999
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação Para a Ciência e Tecnologia
Concluded

Contract

Designation Funders
2021/04/01 - 2023/09/30 Test, Track, and Innovate in COVID-19 Diagnosis
02/SAICT/2020
Researcher
Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização, Portugal
Ongoing
2021/09/01 - 2023/08/31 ORACLE: BiOmarkeR-integrated targeted therapies Approach for non-small Cell Lung CancEr
UIDP/Multi/00709/2020
Principal investigator
Fundação para a Ciência e a Tecnologia, Portugal
Ongoing
2022/07/01 - 2023/06/30 Vaginal gel for topical application in precancerous lesions caused by the Human Papilloma Virus
CENTRO-01-0145-FEDER-181235
Principal investigator
Comissão de Coordenação e Desenvolvimento Regional do Centro, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Ongoing
2017/01/01 - 2022/12/31 International Doctoral Training Program in Magnetic Resonance Applied to Chemistry, Materials and Biosciences
PD/00065/2013
Local Coordinator at CICS-UBI
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/11/01 - 2022/10/31 CombinatiOn aptaMer-drug Based therapeutics for ocular neovascular dIsease
UIDP/Multi/00709/2020
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Ongoing
2019/01/01 - 2022/06/30 Ionic Liquid-based supports for pre-miRNAs purification targeting Alzheimer's disease
02/SAICT/2017: POCI-01-0145-FEDER-029496
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2021/12/31 Production of the full-length nucleolin for structural studies
10168
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Instruct-ERIC Hub
Concluded
2019/01/01 - 2021/12/31 KRAS G-quadruplexes as an innovative theragnostic strategy for cervical cancer
5079/2019
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/01/01 - 2021/12/31 Portuguese Nuclear Magnetic Resonance Network-PTNMR
PINFRA/22161/2016
Local Coordinator at CICS-UBI
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/09/01 - 2021/12/31 Nucleolin targeting by G-quadruplex aptamers for cervical cancer therapy
IF/00959/2015/CP1300/CT0002
Principal investigator
Fundação para a Ciência e a Tecnologia, Portugal
Concluded
2018/09/01 - 2021/08/31 Multifunctional Nanoseeds for Chemoradiotherapy of Glioblastoma
PTDC/MED-QUI/29649/2017
Researcher
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento
Concluded
2021/03/01 - 2021/06/30 CovidOUT - Mask and nose spray to reduce transmission of the new coronavirus
69358
Researcher
HPRD – Health Products Research and Development Lda, Portugal
Concluded
2018/11/05 - 2020/10/30 DRug dElivery nAnosysteM for HPV infection therapy
UTAP-EXPL/NTec/0015/2017
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2020/05/25 - 2020/08/24 Track and Trace COVID-19
149_596826219
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/05/01 - 2020/04/30 Desafios interdisciplinares em Neurodegeneração (ICON)
CENTRO-01-0145-FEDER-000013
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundo Europeu de Desenvolvimento Regional
Concluded
2018/09/01 - 2020/02/27 BIOmedical DEVICE development based on pre-miRNA G-quadruplex
MIT-EXPL/BIO/0008/2017
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação Para a Ciência e Tecnologia
Concluded
2017/01/01 - 2019/12/31 G-quadruplex aptamers for cervical cancer therapy
TC-15/17
Principal investigator
Conselho de Reitores das Universidades Portuguesas, Portugal
 Conselho de Reitores das Universidades Portuguesas
Concluded
2018/01/01 - 2018/12/31 Development of drug delivery nanocarrier for HPV infection - ref. 45/2018
ref. 45/2018
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação Luso-Americana (FLAD) Healthcare 2020
Concluded
2013/01/01 - 2016/01/01 Hormonal and Inflammatory basis of age-related diseases
CENTRO-07-ST24-FEDER-002015
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Referência Estratégico Nacional
Concluded
2014/01/01 - 2015/12/31 G-quadruplex binders for cancer therapy
EXPL/QEQ-MED/1068/2013
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2004/01/01 - 2007/01/01 Activity Against Mycobacterium Tuberculosis and Mycobacterium avium Complex, and Immunomodulation by Macrocyclic Compounds
POCTI/ESP/35877/1999
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2003/01/01 - 2004/01/01 Non-Symmetric Macrocycles for Metal Complexes and Supramolecular Aggregates with Pesticides
POCTI/QUI/35396/1999
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2019/01/01 - Current Determination of the expression of circulating miRNAs in samples of blood of patients diagnosed with lung cancer - Clinical study nº 35/2019
nº 35/2019
Principal investigator
Centro Hospitalar Cova da Beira EPE, Portugal
Ongoing
2020/12/23 - 2021/12/31 Track and Trace COVID-19 - Clinical study nº74/2020
nº74/2020
Principal investigator
Centro Hospitalar Cova da Beira EPE, Portugal
Concluded
2019/04/01 - 2020/12/31 Determination of expression of nucleolin in blood samples from patients diagnosed with prostate cancer - Clinical study n.º 31/PI/2019
31/PI/2019
Principal investigator
Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Portugal
Concluded
2018/02/01 - 2020/12/31 Drug delivery nanosystem for therapy of HPV infection - Clinical study nº 92/2018
92/2018
Principal investigator
Centro Hospitalar Cova da Beira EPE, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Cruz, Carla. Corresponding author: Cruz, Carla. "Aptamer-based microfluidics for circulating tumor cells". In Aptamers Engineered Nanocarriers for Cancer Therapy - Elsevier. 2022.
    Under revision
  2. Carla Cruz 0000-0001-6630-1242. Corresponding author: Carla Cruz 0000-0001-6630-1242. "Aptamer-functionalized quantum dots for targeted cancer therapy". In Aptamers Engineered Nanocarriers for Cancer Therapy. 2022.
    Published
Conference abstract
  1. Cruz, Carla. Corresponding author: Cruz, Carla. "Tiago Santos; André Miranda; Lionel Imbert; Gilmar F. Salgado; Eurico J. Cabrita; Carla Cruz. Targeting a G-quadruplex from let-7e pre-miRNA with small molecules and nucleolin.". Paper presented in RSC: CHEMICAL BIOLOGY SYMPOSIUM 2022., 2022.
  2. Carla Cruz. Corresponding author: Carla Cruz. "Figueiredo, J., Carreira-Barral, I., Quesada, R., Mergny, J-L., Cruz, C., Phenanthroline-based derivatives as G-quadruplex pre-MIR150 binders: Synthesis and evaluation.". Paper presented in 4th National organic chemistry meeting and 7th National Medicinal Chemistry Meeting, 2022.
    Accepted
  3. Cruz, Carla. Corresponding author: Cruz, Carla. "Daniela Alexandre, Tiago Santos, Jéssica Lopes-Nunes, André Miranda, Joana Figueiredo, Micael Silva, Jean-Louis Mergny, Pedro V.Batista, Carla Cruz, Structural characterization of a G-quadruplex aptamer and their ligands". Paper presented in 14th National Organic Chemistry Meeting, 7th National Medicinal Chemistry Meeting, 2022.
    Accepted
  4. Cruz, Carla. Corresponding author: Cruz, Carla. "Jéssica Lopes-Nunes, José Lifante, Yingli Shen, Erving C. Ximendes, M. Carmen Iglesias-de la Cruz, Daniel Jaque, Carla Cruz, ICG-tagged aptamer as drug delivery system for malignant melanoma". Paper presented in COST Action CA17140 STSM Conference, 16 March 2022, virtual meeting, 2022.
    Accepted
  5. Cruz, Carla. Corresponding author: Cruz, Carla. "André Miranda; Roi Lopez-Blanco; Eduardo Fernandez-Megia; Carla Cruz. Development of aptadendrimers for prostate cancer therapy.". Paper presented in 1st CA17140 STSM Virtual Conference, 2022.
    Accepted
  6. Cruz, Carla. Corresponding author: Cruz, Carla. "Figueiredo, J., Carreira-Barral, I., Quesada, R., Mergny, J-L., Cruz, C., Synthesis and evaluation of phenanthroline-based derivatives as human pre-MIR150 G-quadruplex binders for lung cancer therapy,". Paper presented in First CA17140 STSM Virtual Conference, 2022.
  7. Cruz, Carla. Corresponding author: Cruz, Carla. "Jéssica Lopes-Nunes, Paula A Oliveira, Carla Cruz, AS1411 derivatives G-quadruplex for Acridine Orange Derivatives Delivery". Paper presented in Innovative ThERApeutiC Targets In nOn-canonical Nucleic acids structures Winter InterNational School 2021, 2021.
    Accepted
  8. Cruz, Carla. Corresponding author: Cruz, Carla. "Tiago Santos, André Miranda, Lionel Imbert, David Monchaud, Gilmar Salgado, Eurico Cabrita, Carla Cruz: Formation of a RNA G-quadruplex in pre-let-7e and its interaction with ligands and nucleolin". Paper presented in InteractionWins 2021 - Virtual Winter School., 2021.
    Accepted
  9. Cruz, Carla. Corresponding author: Cruz, Carla. "Jéssica Lopes-Nunes, Paula A Oliveira, Carla Cruz, Development of novel aptamer-functionalized liposomes for oral cancer therapy". Paper presented in 7th International Electronic Conference on Medicinal Chemistry, 2021.
    Accepted
  10. Cruz, Carla. Corresponding author: Cruz, Carla. "Tiago Santos, Lionel Imbert, Gilmar Salgado, Eurico J. Cabrita, Carla Cruz, RNA G-quadruplexes as nanotools to target nucleolin in cancer cells". Paper presented in 1st Symposium on Advanced Technologies for Drug Delivery, 2021.
    Accepted
  11. Cruz, Carla. Corresponding author: Cruz, Carla. "Jéssica Lopes-Nunes, Paula A Oliveira, Carla Cruz, AS1411 derivatives-functionalized liposomes for anticancer drug delivery in oral cancer". Paper presented in 1st Symposium on Advanced Technologies for Drug Delivery,, 2021.
    Accepted
  12. Cruz, Carla. Corresponding author: Cruz, Carla. "Pedro Simões, Jéssica Lopes-Nunes, Cândida Tomaz, Carla Cruz, Development of RNA Functionalized Nanoparticle for Oral Cancer Therapy". Paper presented in UT Austin Portugal 2021 Annual Conference, 2021.
    Accepted
  13. Cruz, Carla. Corresponding author: Cruz, Carla. "Figueiredo, J., Carreira-Barral, I., Quesada, R., Mergny, J-L., Cruz, C., Synthesis and development of phenanthroline-based derivatives to interact with the G-quadruplex motif present in human pre-MIR150". Paper presented in First Cost Action CA17140 Conference, 2021.
    Accepted
  14. Cruz, Carla. Corresponding author: Cruz, Carla. "André Miranda, Tiago Santos, Eric Largy, Carla Cruz. Flanking duplex can be a locking mechanism of structural polymorphism of AS1411 aptamer maintaining their properties?". Paper presented in 1st Symposium on Oligonucleotide Technologies and Therapeutics, Portugal, OTP2021, 2021.
  15. Cruz, Carla. Corresponding author: Cruz, Carla. "Figueiredo, J., Mergny, J-L., Cruz, C., Characterization of G-quadruplex structure in pre-MIR150: potential target for anti-cancer approaches in non-small cell lung cancer". Paper presented in International Symposium on SupraBiomolecular Systems 2021, 2021.
  16. Cruz, Carla. Corresponding author: Cruz, Carla. "Characterization of G-quadruplex structure in pre-MIR150: potential target for anti-cancer approaches in non-small cell lung cancer.". Paper presented in International Symposium on SupraBiomolecular Systems 2021, 2021.
  17. Cruz, Carla. Corresponding author: Cruz, Carla. "Tiago Santos; André Miranda; Lionel Imbert; Gilmar F. Salgado; Cabrita, Eurico J.; Carla Cruz. Formation of a G-quadruplex structure by a sequence found in pre-miRNA-let-7e". Paper presented in International Symposium on SupraBiomolecular Systems 2021, 2021.
    Accepted
  18. Cruz, Carla. Corresponding author: Cruz, Carla. "Tiago Santos, Lionel Imbert, Gilmar Salgado, Eurico Cabrita, Carla Cruz: Insights into pre-miRNA-149 G-quadruplex recognition by nucleolin: A structural study.". Paper presented in 9th IberoAmerican NMR meeting/10th GERMN biennial NMR meeting, 2021.
    Accepted
  19. Cruz, Carla. Corresponding author: Cruz, Carla. "Tiago Santos; André Miranda; Andreia Jardim; Catarina Caneira; Virginia Chu; João P. Conde; Lionel Imbert, Carla Cruz. Pre-miR-149 G-quadruplex as a molecular recognition agent of Nucleolin.". Paper presented in Applied Nanotechnology and Nanoscience International Conference 2021, 2021.
    Accepted
  20. Cruz, Carla. Corresponding author: Cruz, Carla. "Jéssica Lopes-Nunes, Ana S Agonia, Tiago Rosado, Eugénia Gallardo, Rita Palmeira-de-Oliveira, Ana Palmeira-de-Oliveira, José Martinez-de-Oliveira, José, Fonseca-Moutinho, Maria Paula Cabral Campello, António Paulo, Andrew D Ellignton, Carla Cruz: Topical Formulation with AS1411-Gold Nanoparticles as Cervical Cancer Drug Delivery System". Paper presented in Applied Nanotechnology and Nanoscience International Conference 2021, 2021.
    Accepted
  21. Cruz, Carla. Corresponding author: Cruz, Carla. "Microfluidic assay based on G-quadruplex aptamer for nucleolin detection in prostate cancer". Paper presented in 1st International Electronic Conference on Biosensors, 2020.
    Accepted
  22. Cruz, Carla. Corresponding author: Cruz, Carla. "Targeting Human Papillomavirus Promoter Regions as a Potential Antiviral Strategy". Paper presented in 33rd International Papillomavirus Conference (IPVC2020), 2020.
    Accepted
  23. Cruz, Carla. Corresponding author: Cruz, Carla. "Nucleolin detection for diagnosis of prostate cancer". Paper presented in Annual Meeting of the American Urological Association, 2020.
    Accepted
  24. Cruz, Carla. Corresponding author: Cruz, Carla. "Nucleolin detection for diagnosis of prostate cancer". Paper presented in III Health Sciences Research Congress: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer, 2019.
    Accepted
  25. Cruz, Carla. Corresponding author: Cruz, Carla. "Detection of the potential cancer biomarker nucleolin in a microfluidic system". Paper presented in III Health Sciences Research Congress: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer, 2019.
    Accepted
  26. Cruz, Carla. Corresponding author: Cruz, Carla. "A reversible miRNA hairpin G- quadruplex Conformational Transition and its biological relevance". Paper presented in III Health Sciences Research Congress: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer, 2019.
    Accepted
  27. Cruz, Carla. Corresponding author: Cruz, Carla. "Formulation of G-Quadruplex Nanosystem for Cervical Cancer Therapy.". Paper presented in III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer, 2019.
    Accepted
  28. Cruz, Carla. Corresponding author: Cruz, Carla. "Evaluation of the Cytotoxic activity of the AS1411-AO-nanosystem for HPV cancer therapy". Paper presented in Nanotechnology in Cancer: Engineering for Oncology, 2019.
    Accepted
  29. Cruz, Carla. Corresponding author: Cruz, Carla. "G-quadruplex aptamers-gold nanoparticles as drug delivery systems for cervical cancer.". Paper presented in Nano Today Conference 2019, 2019.
    Accepted
  30. Cruz, Carla. Corresponding author: Cruz, Carla. "Nucleolin targeting by RNA G-quadruplex of pre-miR-149". Paper presented in International Symposium BIONIC 2018, 2018.
    Accepted
  31. Cruz, Carla. Corresponding author: Cruz, Carla. "NMR studies of G-Quadruplex targeting by ligands". Paper presented in VIII Ibero-American NMR meeting - 6th Iberian NMR Meeting - 9th GERMN - 4th Portuguese RNRMN Meeting, 2018.
    Accepted
  32. Carla Cruz. Corresponding author: Carla Cruz. "Aptamer-based targeted delivery of G-quadruplex ligands in HeLa cervical cancer cells". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
    Accepted
  33. Carla Cruz. Corresponding author: Carla Cruz. "Nanosystem based on AS1411 G-quadruplex derivative for cancer therapy". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
    Accepted
  34. Carla Cruz. Corresponding author: Carla Cruz. "Targeting Human Papilloma Virus G-rich Regions by an Aptamer-based G-quadruplex Ligands Delivery System". Paper presented in Advances in Noncanonical Nucleic Acids, 2017.
    Accepted
  35. Cruz, Carla. Corresponding author: Cruz, Carla. "Selective isolation of G-quadruplex parallel sequences with naphthalene amine affinity support". Paper presented in 6th International Meeting on Quadruplex Nucleic Acids, Prague, 2017.
    Accepted
  36. Carla Cruz. Corresponding author: Carla Cruz. "Structure and ligand binding studies of a G-Quadruplex found in the KRAS proto-oncogene promoter sequence". Paper presented in 6th International Meeting on Quadruplex Nucleic Acids, 2017.
    Accepted
  37. Cruz, Carla. Corresponding author: Cruz, Carla. "Structure and ligand binding studies of a G-Quadruplex found in the KRAS proto-oncogene promoter sequence". Paper presented in 6th International Meeting on Quadruplex Nucleic Acids, 2017.
    Accepted
  38. Cruz, Carla. Corresponding author: Cruz, Carla. "KRAS-22RT G-quadruplex stabilization by Acridine Orange derivatives". Paper presented in 6th International Meeting on Quadruplex Nucleic Acids, 2017.
    Accepted
  39. Cruz, Carla. Corresponding author: Cruz, Carla. "G-quadruplex AS1411 derivative-phenanthroline nanosystem for cervical cancer therapy". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2017.
    Accepted
  40. Cruz, Carla. Corresponding author: Cruz, Carla. "Synthesis and biological evaluation of steroid and polyoxazole derivatives for G-quadruplex binding". Paper presented in International Symposium on Synthesis and Catalysis - ISySyCat, 2015.
    Accepted
  41. Cruz, Carla. Corresponding author: Cruz, Carla. "G-quadruplex production and stabilization". Paper presented in 5th International Meeting on Quadruplex Nucleic Acids, 2015.
    Accepted
  42. Cruz, Carla. Corresponding author: Cruz, Carla. "Development of G-quadruplex calixarene ligands for cancer therapy". Paper presented in EFMC- 1st YOUNG Medicinal Chemist Symposium, 2014.
    Accepted
  43. Cruz, Carla. Corresponding author: Cruz, Carla. "G-quadruplex binders for cancer therapy". Paper presented in XXIII International Symposium on Medicinal Chemistry, 2014.
    Accepted
  44. Cruz, Carla. Corresponding author: Cruz, Carla. "Screening nucleotide binding to amino acid coated supports by surface plasmon resonance and nuclear magnetic resonance". Paper presented in ESBES (9th European Symposium on Biochemical Engineering Science) and ISPPP (32nd International Symposium on the Separation of Proteins, Peptides and Polynucleotides), 2012.
    Accepted
  45. Carla Cruz. Corresponding author: Carla Cruz. "Synthesis and evaluation of the biological activity of new macrocyclic ligands in A7r5 cell line". Paper presented in 21st International Symposium on Medicinal Chemistry, EFMC-ISMC, 2010.
    Accepted
  46. Carla Cruz. Corresponding author: Carla Cruz. "Study of the biological effects of heterocyclic compounds in living cells: in vitro cytotoxicity assay and live-cell imaging microscopy". Paper presented in 21st International Symposium on Medicinal Chemistry, EFMC-ISMC, 2010.
    Accepted
  47. Cruz, Carla. "Effect of free and complexed cations against Mycobacterium tuberculosis". Paper presented in 4th Symposium on Drug Discovery, 2005.
    Accepted
Conference paper
  1. Nunes, Jéssica; Cruz, Carla; Oliveira, Paula. Corresponding author: Cruz, Carla. "Development of novel aptamer-functionalized liposomes for oral cancer therapy". 2021.
    Accepted • 10.3390/ecmc2021-11516
  2. Miranda, André; Cruz, Carla; Santos, Tiago; Carvalho, Josué; Alexandre, Daniela; Jardim, Andreia; Caneira, Catarina; et al. Corresponding author: Cruz, Carla. "Microfluidic assay based on G-quadruplex aptamer for nucleolin detection in prostate cancer". 2020.
    Accepted • 10.3390/iecb2020-07064
  3. Cruz, Carla. "Understanding the role of proto-oncogene Kras G-quadruplexes: Structural and ligand binding characterization". Paper presented in JOINT 12 th EBSA congress and 10 th ICBP - IUPAP congress, 2019.
  4. Cruz, Carla. Corresponding author: Cruz, Carla. "Characterisation of homo-oligonucleotide binding to immobilized amino acids using STD-NMR and SPR spectroscopy". Paper presented in Proceedings of the 14th International Biotechnology Symposium and Exhibition, 2010.
    Accepted
  5. "Molecular dynamics study of the uptake of aromatic carboxylate anions by polyazamacrocycles". Paper presented in Proceedings of the 1st Portuguese Young Chemists Meeting 1st PYCheM, 2008.
    Accepted
  6. "Protonation and coordination properties of a new bis-phenanthroline macrocyclic compound". Paper presented in Proceedings of the XV Spanish-Italian Congress on the Thermodynamics of Metal Complexes — SIMEC 2004, 2004.
    Accepted
Conference poster
  1. "Development of G-Quadruplex Functionalized Liposomes for Anticancer Drugs Delivery". Paper presented in XVI CICS-UBI Symposium, 2021.
  2. "David Moreira, Jéssica Lopes-Nunes, Fátima Santos, Carla Cruz, Cândida Tomaz, Development of Aptamer Nanoparticles for Treatment of Retinal Diseases". Paper presented in XVI CICS-UBI Symposium, 2021.
  3. "Figueiredo, J., Mergny, J-L., Cruz, C., Characterization of G-quadruplex structure in pre-MIR150: potential target for anti-cancer approaches in non-small cell lung cancer". Paper presented in XIV Annual CICS Symposium, 2021.
  4. "Tiago Santos, Gilmar Salgado, Eurico J. Cabrita and Carla Cruz, Identification and characterization of an RNA G-quadruplex as Nucleolin binder". Paper presented in XVI Annual CICS-UBI Symposium, 2021.
  5. "Pedro Simões, Jéssica Lopes-Nunes, Cândida Tomaz, Carla Cruz, Development of RNA Functionalized Nanopaticle for Oral Cancer Therapy". Paper presented in XVI CICS-UBI Symposium, 2021.
  6. Cruz, Carla. Corresponding author: Cruz, Carla. "André Miranda; Tiago Santos; Josué Carvalho; Daniela Alexandre; Virgílio Vaz; Bruno Pereira; Carla Cruz. Nucleolin: a clinically relevant biomarker in prostate cancer patients?". Paper presented in 3th ENJIO - NATIONAL MEETING OF YOUNG RESEARCHERS IN ONCOLOGY 2021, 2021.
  7. Cruz, Carla. Corresponding author: Cruz, Carla. "Pedro Simões, Jéssica Lopes-Nunes, Carla Cruz, Desenvolvimento de Nanopartículas Funcionalizadas com RNA para Terapia do Cancro Oral". Paper presented in National Meeting of Young Oncology Researchers, 2021.
  8. Cruz, Carla. Corresponding author: Cruz, Carla. "Figueiredo, J., Lopes-Nunes, J., Miranda, A., Carvalho, J., Alexandre, D., Valente, S., Cruz, C., Estudo da expressão da proteína nucleolina no cancro do pulmão de não-pequenas células". Paper presented in National Meeting of Young Researchers in Oncology, Portuguese League Against Cancer, 2021.
  9. Cruz, Carla. Corresponding author: Cruz, Carla. "Jéssica Lopes-Nunes, Paula A Oliveira, Carla Cruz, Desenvolvimento de lipossomas funcionalizados com aptameros de G-quadruplex para entrega de compostos anticancerígenos". Paper presented in National Meeting of Young Oncology Researchers, 2021.
  10. "Tiago Santos, André Miranda, Lionel Imbert, Gilmar Salgado, Eurico Cabrita, Carla Cruz: Formation of a G-quadruplex by pre-miRNA-149 and its interaction with nucleolin protein.". Paper presented in 1st Symposium on Oligonucleotide Technologies and Therapeutics, 2021.
  11. "Tiago Santos, Gilmar Salgado, Eurico Cabrita, Carla Cruz: RNA G-quadruplex: a strategy in the target of cell surface nucleolin.". Paper presented in Eucaryotic initiation factors, Meeting of ARNA Laboratory, Université de Bordeaux, 2021.
  12. "André Miranda, Tiago Santos, Eric Largy,Carla Cruz. Flanking duplex can be a locking mechanism of structural polymorphism of AS1411 aptamer maintaining their properties?". Paper presented in National Meeting with Science and Technology, 2021.
  13. "Jéssica Lopes-Nunes, Paula A Oliveira, Carla Cruz, Topical Formulation of AS1411 Gold Nanoparticles as Cervical Cancer Drug Delivery System". Paper presented in Science Meeting 2021, 2021.
  14. Cruz, Carla. Corresponding author: Cruz, Carla. "Tiago Santos, Lionel Imbert, Gilmar Salgado, Eurico Cabrita, Carla Cruz: RNA G-quadruplexes in pre-miRNAs: A new way in the target of nucleolin". Paper presented in WG2 ONLINE CA17140 COST CONFERENCE Characterisation of nanomaterials towards safe and efficient nanodrugs, 2021.
  15. Cruz, Carla. Corresponding author: Cruz, Carla. "Jéssica Lopes-Nunes, José Lifante, Yingli Shen, Erving C. Ximendes, Daniel Jaque, M. Carmen Iglesias-de la Cruz, Carla Cruz, ICG-tagged aptamer as drug delivery system for malignant melanoma". Paper presented in WG2 ONLINE CA17140 COST CONFERENCE Characterization of nanomaterials towards safe and efficient nanodrug, 2021.
  16. Cruz, Carla. Corresponding author: Cruz, Carla. "André Miranda,Tiago Santos, Eric Largy,Carla Cruz. Could a dual elongation of the AS1411 aptamer sequence induce a lock on structural polymorphism and maintenance of properties?". Paper presented in International Symposium on SupraBiomolecular Systems 2021, 2021.
  17. Cruz, Carla. Corresponding author: Cruz, Carla. "Figueiredo, J., Mergny, J-L., Cruz, C., Characterization of G-quadruplex structure in pre-MIR150: potential target for anti-cancer approaches in non-small cell lung cancer". Paper presented in International Symposium on SupraBiomolecular Systems 2021, 2021.
  18. Cruz, Carla. Corresponding author: Cruz, Carla. "André Miranda, Tiago Santos, Eric Largy, Carla Cruz. Lock of AS1411 polymorphism with a flanking duplex.". Paper presented in 9th IberoAmerican NMR meeting/10th GERMN biennial NMR meeting, 2021.
  19. "Detection of Nucleolin Using a Microfluidic Assay Based on G Quadruplex Aptamer". Paper presented in Science and Technology Summit in Portugal - Ciência 2020, 2020.
  20. "Recognition of nucleolin by interaction with an RNA G-quadruplex motif". Paper presented in I Semana da Investigação do Centro Hospitalar Universitário Cova da Beira, 2020.
  21. "Formulation of nanoparticles with AS1411 for drug delivery in HPV lesions". Paper presented in I Semana da Investigação do Centro Hospitalar Universitário Cova da Beira, 2020.
  22. "Reversible conformational transition between duplex and g-quadruplex in pre-mir- 150 and their biological relevance in the development of non-small cell lung cancer". Paper presented in ANNUAL CICS-UBI SYMPOSIUM 2020, 2020.
  23. "As1411- Gold Nanoparticles as Cervical Cancer Drug Delivery System". Paper presented in XV Annual CICS-UBI Symposium, 2020.
  24. Cruz, Carla. Corresponding author: Cruz, Carla. "Biological relevance of pre-miR-150 in the development of non-small cell lung cancer.". Paper presented in ENJIO - NATIONAL MEETING OF YOUNG RESEARCHERS IN ONCOLOGY, 2020.
  25. Cruz, Carla. Corresponding author: Cruz, Carla. "Development of nanoparticle formulations for topical drug deliver". Paper presented in II National Meeting of Young Researchers in Oncology, 2020.
  26. "From fundamental research to clinical practice- World Cancer Day 2020 seminars". Paper presented in World Cancer Day 2020 seminars, 2020.
  27. Cruz, Carla. Corresponding author: Cruz, Carla. "Molecular Beacon Derived from AS1411 for Nucleolin Detection". Paper presented in III Health Sciences Research Congress: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer, 2019.
  28. Cruz, Carla. Corresponding author: Cruz, Carla. "Nucleolin/miR-149 complex: A strategy in the target of prostate cancer cells.". Paper presented in III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer, 2019.
  29. Cruz, Carla. Corresponding author: Cruz, Carla. "Formulation of a nanosystem-loaded topical gel for cervical cancer therapy". Paper presented in UT Austin Portugal Program 2019 Annual Conference Create Knowledge, Foster Change: Towards a New Decade of Joint Achievements, 2019.
  30. "Development of nanoparticle formulations for topical drug delivery". Paper presented in I Encontro Nacional de Jovens Investigadores em Oncologia, Liga Portuguesa Contra o Cancro, 2019.
  31. "The pre-miRNA 149 -nucleolin complex: An integrated strategy to assembly the complex for the targeting of prostate cancer cells". Paper presented in XIV Annual CICS-UBI Symposium, 2019.
  32. "G-Quadruplex Aptamer Beacons for the Detection of Nucleolin". Paper presented in XIV Annual CICS-UBI Symposium, 2019.
  33. "AS1411 derivatives as carriers of G-quadruplex ligands for cervical cancer cells". Paper presented in XIV Annual CICS-UBI Symposium, 2019.
  34. "Nucleolin detection for diagnosis of prostate cancer". Paper presented in XIV Annual CICS-UBI Symposium, 2019.
  35. "Aptamer-guided acridine derivatives for cervical cancer". Paper presented in XIV Annual CICS-UBI Symposium, 2019.
  36. Cruz, Carla. Corresponding author: Cruz, Carla. "G-quadruplex enrobed nanovesicles against Kras-dependent cancers". Paper presented in 6th Nano Today Conference, 2019.
  37. Cruz, Carla. Corresponding author: Cruz, Carla. "Screening of G-quadruplex Ligands for Human Papillomaviruses". Paper presented in Biology of non-canonical nucleic acids: from humans to pathogens - BIONIC 2018, 2018.
  38. Cruz, Carla. Corresponding author: Cruz, Carla. "Purification of Influenza DNA vaccine using pHEMA cryogel support". Paper presented in European Society of Biochemical Engineering Sciences 2018, 2018.
  39. Cruz, Carla. Corresponding author: Cruz, Carla. "Study of the interaction between an a RNA G-quadruplex aptamer and ligands". Paper presented in XII Annual CICS-UBI Symposium, 2018.
  40. Cruz, Carla. Corresponding author: Cruz, Carla. "G-quadruplex DNA aptamer for cervical cancer therapy". Paper presented in XII Annual CICS-UBI Symposium, 2018.
  41. Cruz, Carla. Corresponding author: Cruz, Carla. "Acridine orange derivatives binding to RNA G-quadruplex and potential use in nucleolin targeting,". Paper presented in XIII Annual CICS-UBI symposium, 2018.
  42. Cruz, Carla. Corresponding author: Cruz, Carla. "Development of a NMR bioreactor for the evaluation of 5-Fluorouracil cytotoxicity in living human cells". Paper presented in XII Annual CICS-UBI Symposium, 2018.
  43. Cruz, Carla. Corresponding author: Cruz, Carla. "Production of G-quadruplex pre-miRNA-149 and its purification by affinity chromatography". Paper presented in XIII Annual CICS-UBI symposium 2018, 2018.
  44. Cruz, Carla. Corresponding author: Cruz, Carla. "Drug delivery G-quadruplex aptamer for cervical cancer therapy". Paper presented in XII Annual CICS-UBI Symposium, 2018.
  45. Cruz, Carla. Corresponding author: Cruz, Carla. "NMR studies of G-Quadruplex targeting by ligands". Paper presented in VIII Ibero-American NMR meeting - 6th Iberian NMR Meeting - 9th GERMN - 4th Portuguese RNRMN Meeting, 2018.
  46. Cruz, Carla. Corresponding author: Cruz, Carla. "Nucleolin as target of RNA G-quadruplex aptamer for prostate cancer diagnosis". Paper presented in 6th National Meeting of Chemistry Students, 2018.
  47. Cruz, Carla. Corresponding author: Cruz, Carla. "Stabilization of modified AS1411 G-quadruplex aptamer by acridine orange and phenantrolines derivatives for cervical cancer therapy". Paper presented in Encontro Nacional de Estudantes de Química (ENEQUI), 2018.
  48. Cruz, Carla. Corresponding author: Cruz, Carla. "G-quadruplex AS1411 DNA derivatives for cervical cancer therapy,". Paper presented in Encontro Nacional de Estudantes de Química (ENEQUI), 2018.
  49. Cruz, Carla. Corresponding author: Cruz, Carla. "Development of drug delivery systems based on G-quadruplex aptamers". Paper presented in Encontro Nacional de Estudantes de Química (ENEQUI), 2018.
  50. Cruz, Carla. Corresponding author: Cruz, Carla. "Purification of Influenza DNA vaccine by a pHEMA cryogel support". Paper presented in XIII Annual CICS-UBI symposium, 2017.
  51. Cruz, Carla. Corresponding author: Cruz, Carla. "Acridine orange derivatives binding to RNA G-quadruplex and potential use in nucleolin targeting". Paper presented in XIII Annual CICS-UBI Symposium, 2017.
  52. Cruz, Carla. Corresponding author: Cruz, Carla. "Ligands effects on stabilization of DNA G-quadruplex aptamer". Paper presented in XII Annual CICS-UBI Symposium, 2017.
  53. Cruz, Carla. Corresponding author: Cruz, Carla. "New affinity support to isolate G4 parallel sequences". Paper presented in II Congress in Health Sciences Research: Towards innovation and entrepreneurship, 2017.
  54. Cruz, Carla. Corresponding author: Cruz, Carla. "Study of the interaction between a novel indole-based compound and the biologically relevant c-MYC G-quadruplex". Paper presented in 1st joint French-Portuguese NMR and XXVII GERM Conference, 2016.
  55. Cruz, Carla. Corresponding author: Cruz, Carla. "Purification of plasmid DNA using a chromatographic support derived from G-quadruplex ligands". Paper presented in XVI Latin-American Congress on Chromatography and 9th National Meeting on Chromatography, 2016.
  56. Cruz, Carla. Corresponding author: Cruz, Carla. "Purification of the supercoiled G-quadruplex pDNA for in vitro transcription". Paper presented in XVI Latin-American Congress on Chromatography and 9th National Meeting on Chromatography, 2016.
  57. Cruz, Carla. "Novel superporous arginine matrix for supercoiled p53 encoding plasmid isolation". Paper presented in MicroBiotec'15, 2015.
  58. Cruz, Carla. Corresponding author: Cruz, Carla. "Purification of G-quadruplex supercoiled plasmid DNA with chromatographic supports based on amino acids". Paper presented in I Congress in Health Sciences Research: Towards Innovation and Entrepreneurship, 2015.
  59. Cruz, Carla. Corresponding author: Cruz, Carla. "Development of a chromatographic support using synthesized G-quadruplex ligands". Paper presented in X Annual CICS-UBI Symposium, 2015.
  60. Cruz, Carla. "Screening of histidine-based ligands to modify monolithic supports and purify the supercoiled isoform of different plasmids". Paper presented in 6th Monolith Summer School & Symposium, 2014.
  61. Cruz, Carla. Corresponding author: Cruz, Carla. "Biorecognition study of oligonucleotides and plasmid DNA to L-methionine chromatography support". Paper presented in Micro Biotech13 - Portuguese Congress of Microbiology and Biotechnology, 2013.
  62. Cruz, Carla. Corresponding author: Cruz, Carla. "Binding evaluation of G-quadruplex ligands". Paper presented in XXVth International Conference on Magnetic Resonance in Biological Systems, 2012.
  63. Cruz, Carla. Corresponding author: Cruz, Carla. "Binding analysis between immobilized L-Histidine and oligonucleotides using surface plasmon resonance and nuclear magnetic resonance spectroscopy". Paper presented in 2nd PTNMR Meeting - NMR, 2012.
  64. Cruz, Carla. Corresponding author: Cruz, Carla. "Direct detection of nucleotides binding to L-histidine chromatography supports by STD-NMR spectroscopy". Paper presented in EUROMAR 2010 and 17th ISMAR Conference, 2010.
  65. Cruz, Carla. "Molecular design of macrocyclic receptors containing two phenanthroline units and evaluation of their binding ability". Paper presented in II International Symposium on Macrocyclic and Supramolecular Chemistry ISMSC 2007, 2007.
  66. Cruz, Carla. "Molecular recognition studies between a novel bis-phenanthroline macrocyclic receptor and aromatic carboxylate anions". Paper presented in XXX International Symposium on Macrocyclic Chemistry ISMC 2005, 2005.
  67. Cruz, Carla. "Molecular recognition of carboxilate anions by a polyaza macrocyclic receptor". Paper presented in XXXVI International Conference on Coordination Chemistry ICCC36, 2004.
  68. Cruz, Carla. "Dinuclear copper and zinc complexes of a hexaazamacrocycle containing p-xylyl spacers and bridging anions. Molecular modelling and spectroscopic studies". Paper presented in XXVIII International Symposium on Macrocyclic Chemistry ¿ ISMC 2003, 2003.
  69. Cruz, Carla. "Metal complexes of a dipyridine octaazamacrocycle: Stability constants and structural studies". Paper presented in XXVIII International Symposium on Macrocyclic Chemistry ISMC 2003, 2003.
  70. Cruz, Carla. "Metal complexes of 30- and 40-membered dipyridine oxaazamacrocycles". Paper presented in 7th FIGIPS Meeting in Inorganic Chemistry, 2003.
  71. Cruz, Carla. "Molecular recognition of anions by dipyridine octaazamacrocycle: an investigation by NMR spectroscopy and molecular dynamics studies". Paper presented in 7th FIGIPS Meeting in Inorganic Chemistry, 2003.
Journal article
  1. Lopes-Nunes, Jéssica; Oliveira, Paula A.; Cruz, Carla. Corresponding author: Cruz, Carla. "Enhanced targeted liposomal delivery of imiquimod via aptamer functionalization for head and neck cancer therapy". Colloids and Surfaces B: Biointerfaces 243 (2024): 114121. http://dx.doi.org/10.1016/j.colsurfb.2024.114121.
    Published • 10.1016/j.colsurfb.2024.114121
  2. Lopes-Nunes, Jéssica; Oliveira, Paula A.; Cruz, Carla. Corresponding author: Cruz, Carla. "Nanotherapy for human papillomavirus-associated cancers: breakthroughs and challenges". Trends in Pharmacological Sciences (2024): http://dx.doi.org/10.1016/j.tips.2024.07.004.
    Published • 10.1016/j.tips.2024.07.004
  3. Moreira, David; Alexandre, Daniela; Miranda, André; Lourenço, Pedro; Baptista, Pedro V.; Tomaz, Cândida; Lu, Yi; Cruz, Carla. Corresponding author: Cruz, Carla. "Detecting mir-155-3p through a Molecular Beacon Bead-Based Assay". Molecules 29 13 (2024): 3182. http://dx.doi.org/10.3390/molecules29133182.
    10.3390/molecules29133182
  4. Maocha, Izamara; Rosado, Beatriz; Lopes-Nunes, Jéssica; Lopes, Melanie; Rolo, Joana; Pires, Bruno; Gallardo, Eugénia; et al. Corresponding author: Cruz, Carla. "Imiquimod-Loaded Nanosystem for Treatment Human Papillomavirus-Induced Lesions". Pharmaceutics 16 7 (2024): 864. http://dx.doi.org/10.3390/pharmaceutics16070864.
    10.3390/pharmaceutics16070864
  5. Miranda, André; Cucchiarini, Anne; Esnault, Cyril; Andrau, Jean-Christophe; Oliveira, Paula A.; Mergny, Jean-Louis; Cruz, Carla. Corresponding author: Cruz, Carla. "G-quadruplex forming motifs in the promoter region of the B-MYB proto-oncogene". International Journal of Biological Macromolecules 270 (2024): 132244. http://dx.doi.org/10.1016/j.ijbiomac.2024.132244.
    Published • 10.1016/j.ijbiomac.2024.132244
  6. Lourenço, Pedro; Miranda, André; Campello, Maria Paula Cabral; Paulo, António; Louis-Mergny, Jean; Cruz, Carla. Corresponding author: Cruz, Carla. "Targeting proto-oncogene B-MYB G-quadruplex with a nucleic acid–based fluorescent probe". International Journal of Biological Macromolecules 266 (2024): 131055. http://dx.doi.org/10.1016/j.ijbiomac.2024.131055.
    Published • 10.1016/j.ijbiomac.2024.131055
  7. Gamboa, Joana; Pedro Lourenço 071C-E24D-2A32; Cruz, Carla; F617-5CA5-EF61. Corresponding author: Cruz, Carla. "Aptamers for the Delivery of Plant-Based Compounds: A Review". Pharmaceutics (2024): 10.3390/pharmaceutics16040541.
    Published
  8. Palma, Elisa; Içhedef, Cigdem; Fernandes, Célia; Belchior, Ana; Raposinho, Paula; Gano, Lurdes; Miranda, André; et al. "Targeting of G-quadruplex DNA with 99mTc(I)/Re(I) Tricarbonyl Complexes Carrying Pyridostatin Derivatives". Chemistry – A European Journal (2024): http://dx.doi.org/10.1002/chem.202400285.
    Published • 10.1002/chem.202400285
  9. Alexandre, Daniela; Fernandes, Alexandra R.; Baptista, Pedro V.; Cruz, Carla. Corresponding author: Cruz, Carla. "Evaluation of miR-155 silencing using a molecular beacon in human lung adenocarcinoma cell line". Talanta 274 (2024): 126052. http://dx.doi.org/10.1016/j.talanta.2024.126052.
    Published • 10.1016/j.talanta.2024.126052
  10. Figueiredo, Joana; Mergny, Jean-Louis; Cruz, Carla. Corresponding author: Cruz, Carla. "G-quadruplex ligands in cancer therapy: Progress, challenges, and clinical perspectives". Life Sciences 340 (2024): 122481. http://dx.doi.org/10.1016/j.lfs.2024.122481.
    Published • 10.1016/j.lfs.2024.122481
  11. Lopes-Nunes, Jéssica; Simões, Pedro; Moreira, David; Leandro, Kevin; Nobre, Rui Jorge; Pereira de Almeida, Luís; Campello, Maria Paula Cabral; et al. Corresponding author: Cruz, Carla. "RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation". International Journal of Biological Macromolecules 259 (2024): 129157. http://dx.doi.org/10.1016/j.ijbiomac.2023.129157.
    Published • 10.1016/j.ijbiomac.2023.129157
  12. Joana Figueiredo; Mojgan Djavaheri-Mergny; Lucille Ferret; Jean-Louis Mergny; Carla Cruz. Corresponding author: Carla Cruz. "Harnessing G-quadruplex ligands for lung cancer treatment: A comprehensive overview". Drug Discovery Today (2023): https://doi.org/10.1016/j.drudis.2023.103808.
    Published • 10.1016/j.drudis.2023.103808
  13. Santos, Tiago; Silva, Micael; Imbert, Lionel; Campello, Maria P. C.; Paulo, António; Amrane, Samir; Salgado, Gilmar F.; Cruz, Carla; Cabrita, Eurico J.. Corresponding author: Cruz, Carla. "Structural Perspective into the Interaction of an Oncogenesis-Relevant pre-miRNA G-Quadruplex Ligand Carrier with the Protein Nucleolin". Chemistry – A European Journal (2023): http://dx.doi.org/10.1002/chem.202301181.
    Published • 10.1002/chem.202301181
  14. Cruz, Carla; Lopes-Nunes, Jéssica; Santos, Fátima Milhano; Campello, Maria Paula Cabral; Oliveira, Maria Cristina; Paulo, António; Tomaz, Cândida; Cruz, Carla. Corresponding author: Cruz, Carla. "Assessment of Aptamer as a Potential Drug Targeted Delivery for Retinal Angiogenesis Inhibition". Pharmaceuticals 16 5 (2023): 751. http://dx.doi.org/10.3390/ph16050751.
    Published • 10.3390/ph16050751
  15. Santos, Fátima M.; Ciordia, Sergio; Mesquita, Joana; Cruz, Carla; Sousa, João Paulo Castro e; Passarinha, Luís A.; Tomaz, Cândida T.; Paradela, Alberto. "Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory biomarkers of vitreoretinal eye diseases". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1107295.
    10.3389/fimmu.2023.1107295
  16. Miranda, André; Lopez-Blanco, Roi; Lopes-Nunes, Jéssica; Melo, Ana M.; Campello, Maria Paula Cabral; Paulo, António; Oliveira, Maria Cristina; et al. Corresponding author: Cruz, Carla. "Gallic Acid–Triethylene Glycol Aptadendrimers Synthesis, Biophysical Characterization and Cellular Evaluation". Pharmaceutics 14 11 (2022): 2456. http://dx.doi.org/10.3390/pharmaceutics14112456.
    10.3390/pharmaceutics14112456
  17. Figueiredo, Joana; Carreira-Barral, Israel; Quesada, Roberto; Mergny, Jean-Louis; Cruz, Carla. Corresponding author: Cruz, Carla. "Synthesis and evaluation of 2,9-disubstituted-1,10-phenanthroline derivatives as G-quadruplex binders". Bioorganic & Medicinal Chemistry 73 (2022): 116971. http://dx.doi.org/10.1016/j.bmc.2022.116971.
    10.1016/j.bmc.2022.116971
  18. Moreira, David; Leitão, Daniela; Lopes-Nunes, Jéssica; Santos, Tiago; Figueiredo, Joana; Miranda, André; Alexandre, Daniela; et al. Corresponding author: Cruz, Carla. "G-Quadruplex Aptamer-Ligand Characterization". Molecules 27 20 (2022): 6781. http://dx.doi.org/10.3390/molecules27206781.
    10.3390/molecules27206781
  19. Santos, Tiago; Miranda, André; Imbert, Lionel; Monchaud, David; Salgado, Gilmar F.; Cabrita, Eurico J.; Cruz, Carla. Corresponding author: Cruz, Carla. "Targeting a G-quadruplex from let-7e pre-miRNA with small molecules and nucleolin". Journal of Pharmaceutical and Biomedical Analysis 215 (2022): 114757. http://dx.doi.org/10.1016/j.jpba.2022.114757.
    Published • 10.1016/j.jpba.2022.114757
  20. Santos, Tiago; Lopes-Nunes, Jéssica; Alexandre, Daniela; Miranda, André; Figueiredo, Joana; Silva, Micael S.; Mergny, Jean-Louis; Cruz, Carla. Corresponding author: Cruz, Carla. "Stabilization of a DNA aptamer by ligand binding". Biochimie (2022): http://dx.doi.org/10.1016/j.biochi.2022.05.002.
    Published • 10.1016/j.biochi.2022.05.002
  21. Ramos, Catarina I.V.; Almodôvar, Vitor A.S.; Candeias, Nuno R.; Santos, Tiago; Cruz, Carla; Neves, M. Graça P.M.S.; Tomé, Augusto C.. Corresponding author: Cruz, Carla. "Diketopyrrolo[3,4-c]pyrrole derivative as a promising ligand for the stabilization of G-quadruplex DNA structures". Bioorganic Chemistry 122 (2022): 105703. http://dx.doi.org/10.1016/j.bioorg.2022.105703.
    Published • 10.1016/j.bioorg.2022.105703
  22. Santos, Tiago; Salgado, Gilmar F.; Cabrita, Eurico J.; Cruz, Carla. Corresponding author: Cruz, Carla. "Nucleolin: a binding partner of G-quadruplex structures". Trends in Cell Biology (2022): http://dx.doi.org/10.1016/j.tcb.2022.03.003.
    Published • 10.1016/j.tcb.2022.03.003
  23. Alexandre, Daniela; Teixeira, Bernardo; Rico, André; Valente, Salete; Craveiro, Ana; Baptista, Pedro V.; Cruz, Carla. Corresponding author: Cruz, Carla. "Molecular Beacon for Detection miRNA-21 as a Biomarker of Lung Cancer". International Journal of Molecular Sciences 23 6 (2022): 3330. http://dx.doi.org/10.3390/ijms23063330.
    Published • 10.3390/ijms23063330
  24. Figueiredo, Joana; Peitinho, David; Campello, Maria Paula Cabral; Oliveira, Maria Cristina; Paulo, António; Mergny, Jean-Louis; Cruz, Carla. Corresponding author: Cruz, Carla. "Screening of Scaffolds for the Design of G-Quadruplex Ligands". Applied Sciences 12 4 (2022): 2170. http://dx.doi.org/10.3390/app12042170.
    Published • 10.3390/app12042170
  25. Santos, Tiago; Miranda, André; Imbert, Lionel; Jardim, Andreia; Caneira, Catarina R.F.; Chu, Virgínia; Conde, João P.; et al. Corresponding author: Cruz, Carla. "Pre-miRNA-149 G-quadruplex as a molecular agent to capture nucleolin". European Journal of Pharmaceutical Sciences 169 (2022): 106093. http://dx.doi.org/10.1016/j.ejps.2021.106093.
    10.1016/j.ejps.2021.106093
  26. Maocha, Izamara Gomes; Carvalho, Josué; Lopes-Nunes, Jéssica; Rosado, Tiago; Gallardo, Eugénia; Tomás, Mariana; Palmeira-de-Oliveira, Ana; et al. Corresponding author: Cruz, Carla. "Drug formulations for localized treatment of Human Papillomavirus-induced lesions". Journal of Pharmaceutical Sciences (2022): http://dx.doi.org/10.1016/j.xphs.2022.02.004.
    10.1016/j.xphs.2022.02.004
  27. Silva, Francisco; D’Onofrio, Alice; Mendes, Carolina; Pinto, Catarina; Marques, Ana; Campello, Maria Paula Cabral; Oliveira, Maria Cristina; et al. "Radiolabeled Gold Nanoseeds Decorated with Substance P Peptides: Synthesis, Characterization and In Vitro Evaluation in Glioblastoma Cellular Models". International Journal of Molecular Sciences 23 2 (2022): 617. http://dx.doi.org/10.3390/ijms23020617.
    10.3390/ijms23020617
  28. Carvalho, Josué; Lopes-Nunes, Jéssica; Figueiredo, Joana; Santos, Tiago; Miranda, André; Riscado, Micaela; Sousa, Fani; et al. Corresponding author: Cruz, Carla. "Molecular Beacon Assay Development for Severe Acute Respiratory Syndrome Coronavirus 2 Detection". Sensors 21 21 (2021): 7015. http://dx.doi.org/10.3390/s21217015.
    10.3390/s21217015
  29. Joana Figueiredo; Tiago Santos; André Miranda; Daniela Alexandre; Bernardo Teixeira; Pedro Simões; Jéssica Lopes-Nunes; Carla Cruz. Corresponding author: Carla Cruz. "Ligands as Stabilizers of G-Quadruplexes in Non-Coding RNAs". Molecules 26 20 (2021): 6164-6164. https://doi.org/10.3390/molecules26206164.
    10.3390/molecules26206164
  30. Lopes-Nunes, Jessica; Agonia, Ana S.; Rosado, Tiago; Gallardo, Eugénia; Palmeira-de-Oliveira, Rita; Palmeira-de-Oliveira, Ana; Martinez-de-Oliveira, José; et al. Corresponding author: Cruz, Carla. "Aptamer-Functionalized Gold Nanoparticles for Drug Delivery to Gynecological Carcinoma Cells". Cancers 13 16 (2021): 4038. http://dx.doi.org/10.3390/cancers13164038.
    10.3390/cancers13164038
  31. Tiago Santos; Gilmar F. Salgado; Eurico J. Cabrita; Carla Cruz. Corresponding author: Carla Cruz. "G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions". Pharmaceuticals 14 8 (2021): 769-769. https://doi.org/10.3390/ph14080769.
    10.3390/ph14080769
  32. Carvalho, Josué; Lopes-Nunes, Jéssica; Vialet, Brune; Rosado, Tiago; Gallardo, Eugenia; Vale, João; Eloy, Catarina; et al. Corresponding author: Cruz, Carla. "Nanoaggregate-forming lipid-conjugated AS1411 aptamer as a promising tumor-targeted delivery system of anticancer agents in vitro". Nanomedicine: Nanotechnology, Biology and Medicine 36 (2021): 102429. http://dx.doi.org/10.1016/j.nano.2021.102429.
    10.1016/j.nano.2021.102429
  33. Cadoni, Enrico; Magalhães, Pedro R.; Emídio, Rita M.; Mendes, Eduarda; Vítor, Jorge; Carvalho, Josué; Cruz, Carla; Victor, Bruno L.; Paulo, Alexandra. "New (Iso)quinolinyl-pyridine-2,6-dicarboxamide G-Quadruplex Stabilizers. A Structure-Activity Relationship Study". Pharmaceuticals 14 7 (2021): 669. http://dx.doi.org/10.3390/ph14070669.
    10.3390/ph14070669
  34. Jéssica Lopes-Nunes; Paula Oliveira; Carla Cruz. Corresponding author: Carla Cruz. "G-Quadruplex-Based Drug Delivery Systems for Cancer Therapy". Pharmaceuticals 14 7 (2021): 671-671. https://doi.org/10.3390/ph14070671.
    10.3390/ph14070671
  35. Elisa Palma; Josué Carvalho; Carla Cruz; António Paulo. "Metal-Based G-Quadruplex Binders for Cancer Theranostics". Pharmaceuticals (2021): https://doi.org/10.3390/ph14070605.
    10.3390/ph14070605
  36. Miranda, André; Santos, Tiago; Carvalho, Josué; Alexandre, Daniela; Jardim, Andreia; Caneira, CatarinaR.F.; Vaz, Vírgilio; et al. Corresponding author: Cruz, Carla. "Aptamer-based approaches to detect nucleolin in prostate cancer". Talanta 226 (2021): 122037. http://dx.doi.org/10.1016/j.talanta.2020.122037.
    10.1016/j.talanta.2020.122037
  37. Cruz, Carla; Pedro, Augusto Q.; Carvalho, Josué; Santos, Tiago; Talhada, Daniela; Paiva, Artur; Queiroz, João A.; et al. Corresponding author: Cruz, Carla. "Nucleolin as a potential biomarker for canine malignant neoplasia". Research in Veterinary Science 135 (2021): 297-303. http://dx.doi.org/10.1016/j.rvsc.2020.10.004.
    10.1016/j.rvsc.2020.10.004
  38. André Miranda; Tiago Santos; Eric Largy; Carla Cruz. Corresponding author: Carla Cruz. "Locking up the AS1411 Aptamer with a Flanking Duplex: Towards an Improved Nucleolin-Targeting". Pharmaceuticals (2021): https://doi.org/10.3390/ph14020121.
    10.3390/ph14020121
  39. Carvalho, Josué; Lopes-Nunes, Jéssica; Campello, Maria Paula Cabral; Paulo, António; Milici, Janice; Meyers, Craig; Mergny, Jean-Louis; et al. Corresponding author: Cruz, Carla. "Human Papillomavirus G-Rich Regions as Potential Antiviral Drug Targets". Nucleic Acid Therapeutics 31 1 (2021): 68-81. http://dx.doi.org/10.1089/nat.2020.0869.
    10.1089/nat.2020.0869
  40. Joana Figueiredo; André Miranda; Jéssica Lopes-Nunes; Josué Carvalho; Daniela Alexandre; Salete Valente; Jean-Louis Mergny; Carla Cruz. Corresponding author: Carla Cruz. "Targeting Nucleolin By RNA G-Quadruplex-Forming Motif". Biochemical Pharmacology (2021): https://doi.org/10.1016/j.bcp.2021.114418.
    10.1016/j.bcp.2021.114418
  41. Patrícia Pereira; Maria Barreira; Carla Cruz; Joana Tomás; Ângelo Luís; Augusto Q. Pedro; João A. Queiroz; Fani Sousa. "Brain-Targeted Delivery of Pre-miR-29b Using Lactoferrin-Stearic Acid-Modified-Chitosan/Polyethyleneimine Polyplexes". Pharmaceuticals 13 10 (2020): 314-314. https://doi.org/10.3390/ph13100314.
    10.3390/ph13100314
  42. Lopes-Nunes, Jéssica; Lifante, José; Shen, Yingli; Ximendes, Erving C.; Jaque, Daniel; Iglesias-de la Cruz, M. Carmen; Cruz, Carla. Corresponding author: Cruz, Carla. "Biological studies of an ICG-tagged aptamer as drug delivery system for malignant melanoma". European Journal of Pharmaceutics and Biopharmaceutics 154 (2020): 228-235. http://dx.doi.org/10.1016/j.ejpb.2020.07.018.
    10.1016/j.ejpb.2020.07.018
  43. Santos, Tiago; Miranda, André; Paula Cabral Campello, Maria; Paulo, António; Salgado, Gilmar; Cabrita, Eurico J.; Cruz, Carla. Corresponding author: Cruz, Carla. "Recognition of Nucleolin Through Interaction with RNA G-Quadruplex". Biochemical Pharmacology (2020): 114208. http://dx.doi.org/10.1016/j.bcp.2020.114208.
    10.1016/j.bcp.2020.114208
  44. Lopes-Nunes, Jéssica; Carvalho, Josué; Figueiredo, Joana; Ramos, Catarina I.V.; Lourenço, Leandro M.O.; Tomé, João P.C.; G.P.M.S. Neves, Maria; et al. Corresponding author: Cruz, Carla. "Phthalocyanines for G-quadruplex aptamers binding". Bioorganic Chemistry (2020): 103920. http://dx.doi.org/10.1016/j.bioorg.2020.103920.
    10.1016/j.bioorg.2020.103920
  45. Carvalho, Josué; Mergny, Jean-Louis; Salgado, Gilmar F.; Queiroz, João A.; Cruz, Carla. Corresponding author: Cruz, Carla. "G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies". Trends in Molecular Medicine (2020): http://dx.doi.org/10.1016/j.molmed.2020.05.002.
    10.1016/j.molmed.2020.05.002
  46. Carvalho, Josué; Cruz, Carla. Corresponding author: Cruz, Carla. "Forster resonance energy transfer for studying nucleic acids denaturation: A chemical and biological sciences laboratory experiment". Biochemistry and Molecular Biology Education 48 4 (2020): 329-336. http://dx.doi.org/10.1002/bmb.21353.
    10.1002/bmb.21353
  47. Eddahmi, Mohammed; Moura, Nuno M. M.; Bouissane, Latifa; Faustino, Maria A. F.; Cavaleiro, José A. S.; Paz, Filipe A. A.; Mendes, Ricardo F.; et al. "Synthesis and Biological Evaluation of New Functionalized Nitroindazolylacetonitrile Derivatives". ChemistrySelect 4 48 (2019): 14335-14342. http://dx.doi.org/10.1002/slct.201904344.
    10.1002/slct.201904344
  48. Santos, Tiago; Pereira, Patrícia; Queiroz, João A.; Cruz, Carla; Sousa, Fani. Corresponding author: Cruz, Carla. "Plasmid production and purification: An integrated experiment-based biochemistry and biotechnology laboratory course". Biochemistry and Molecular Biology Education 47 6 (2019): 638-643. http://dx.doi.org/10.1002/bmb.21290.
    10.1002/bmb.21290
  49. Josué Carvalho; Tiago Santos; Rui Carrilho; Fani Sousa; Gilmar F. Salgado; João António Queiroz; Carla Cruz. Corresponding author: Carla Cruz. "Ligand screening to pre-miRNA 149 G-quadruplex investigated by molecular dynamics". Journal of Biomolecular Structure and Dynamics (2019): 1-15. https://doi.org/10.1080/07391102.2019.1632743.
    10.1080/07391102.2019.1632743
  50. Figueiredo, Joana; Lopes-Nunes, Jéssica; Carvalho, Josué; Antunes, Francisca; Ribeiro, Márcia; Campello, Maria Paula Cabral; Paulo, António; et al. Corresponding author: Cruz, Carla. "AS1411 derivatives as carriers of G-quadruplex ligands for cervical cancer cells". International Journal of Pharmaceutics (2019): 118511. http://dx.doi.org/10.1016/j.ijpharm.2019.118511.
    10.1016/j.ijpharm.2019.118511
  51. Santos, Tiago; Pereira, Patrícia; Paula Cabral Campello, Maria; Paulo, António; Queiroz, João A.; Cabrita, Eurico; Cruz, Carla. Corresponding author: Cruz, Carla. "RNA G-quadruplex as supramolecular carrier for cancer-selective delivery". European Journal of Pharmaceutics and Biopharmaceutics (2019): http://dx.doi.org/10.1016/j.ejpb.2019.07.017.
    10.1016/j.ejpb.2019.07.017
  52. Carvalho, Josué; Paiva, Artur; Cabral Campello, Maria Paula; Paulo, António; Mergny, Jean-Louis; Salgado, Gilmar F.; Queiroz, João A.; Cruz, Carla. Corresponding author: Cruz, Carla. "Aptamer-based Targeted Delivery of a G-quadruplex Ligand in Cervical Cancer Cells". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-44388-9.
    Published • 10.1038/s41598-019-44388-9
  53. Ramos, Catarina; Almeida, Susana; Lourenço, Leandro; Pereira, Patrícia; Fernandes, Rosa; Faustino, M.; Tomé, João; et al. "Multicharged Phthalocyanines as Selective Ligands for G-Quadruplex DNA Structures". Molecules 24 4 (2019): 733. http://dx.doi.org/10.3390/molecules24040733.
    10.3390/molecules24040733
  54. Josué Carvalho; Sara Alves; M. Margarida C.A. Castro; Carlos F.G.C. Geraldes; João A. Queiroz; Carla P. Fonseca; Carla Cruz. Corresponding author: Carla Cruz. "Development of a bioreactor system for cytotoxic evaluation of pharmacological compounds in living cells using NMR spectroscopy". Journal of Pharmacological and Toxicological Methods 95 (2019): 70-78. https://doi.org/10.1016/j.vascn.2018.11.004.
    10.1016/j.vascn.2018.11.004
  55. Josué Carvalho; Jéssica Lopes-Nunes; Ana Catarina Lopes; Maria Paula Cabral Campello; António Paulo; João A. Queiroz; Carla Cruz. Corresponding author: Carla Cruz. "Aptamer-guided acridine derivatives for cervical cancer". Organic & Biomolecular Chemistry (2019): https://doi.org/10.1039/C9OB00318E.
    10.1039/C9OB00318E
  56. Santos, Tiago; Brito, Andreia; Boto, Renato; Sousa, Pedro; Almeida, Paulo; Cruz, Carla; Tomaz, Cândida. "Influenza DNA vaccine purification using pHEMA cryogel support". Separation and Purification Technology 206 (2018): 192-198. http://dx.doi.org/10.1016/j.seppur.2018.06.002.
    10.1016/j.seppur.2018.06.002
  57. Josué Carvalho; Edgar Pereira; Julien Marquevielle; Maria P.C. Campello; Jean-Louis Mergny; António Paulo; Gilmar F. Salgado; João A. Queiroz; Carla Cruz. Corresponding author: Carla Cruz. "Fluorescent light-up acridine orange derivatives bind and stabilize KRAS-22RT G-quadruplex". Biochimie 144 (2018): 144-152. https://doi.org/10.1016/j.biochi.2017.11.004.
    10.1016/j.biochi.2017.11.004
  58. Josué Carvalho; Telma Quintela; Nassima M. Gueddouda; Anne Bourdoncle; Jean-Louis Mergny; Gilmar F. Salgado; João A. Queiroz; Carla Cruz. Corresponding author: Carla Cruz. "Phenanthroline polyazamacrocycles as G-quadruplex DNA binders". Organic & Biomolecular Chemistry (2018): https://doi.org/10.1039/C8OB00247A.
    10.1039/C8OB00247A
  59. Santos, T.; Proença, Z.; Queiroz, J.A.; Tomaz, C.; Cruz, C.. Corresponding author: Cruz, C.. "Plasmid purification by using a new naphthalene tripodal support". Separation and Purification Technology 188 (2017): 81-89. http://dx.doi.org/10.1016/j.seppur.2017.06.072.
    10.1016/j.seppur.2017.06.072
  60. Josué Carvalho; João A. Queiroz; Carla Cruz. Corresponding author: Carla Cruz. "Circular Dichroism of G-Quadruplex: a Laboratory Experiment for the Study of Topology and Ligand Binding". Journal of Chemical Education 94 10 (2017): 1547-1551. https://doi.org/10.1021/acs.jchemed.7b00160.
    10.1021/acs.jchemed.7b00160
  61. Diana Costa; Carolina Costa; Margarida Caldeira; Luísa Cortes; João A. Queiroz; Carla Cruz. "Targeting of Cellular Organelles by Fluorescent Plasmid DNA Nanoparticles". Biomacromolecules 18 9 (2017): 2928-2936. https://doi.org/10.1021/acs.biomac.7b00877.
    10.1021/acs.biomac.7b00877
  62. Medeiros-Silva, João; Guédin, Aurore; Salgado, Gilmar F.; Mergny, Jean-Louis; Queiroz, João A.; Cabrita, Eurico J.; Cruz, Carla. Corresponding author: Cruz, Carla. "Phenanthroline-bis-oxazole ligands for binding and stabilization of G-quadruplexes". Biochimica et Biophysica Acta (BBA) - General Subjects 1861 5 (2017): 1281-1292. http://dx.doi.org/10.1016/j.bbagen.2016.11.024.
    10.1016/j.bbagen.2016.11.024
  63. Josué Carvalho; Pierre Nottelet; Jean-Louis Mergny; João A. Queiroz; Gilmar F. Salgado; Carla Cruz. Corresponding author: Carla Cruz. "Study of the interaction between indole-based compounds and biologically relevant G-quadruplexes". Biochimie 135 (2017): 186-195. https://doi.org/10.1016/j.biochi.2017.02.005.
    10.1016/j.biochi.2017.02.005
  64. Gaspar, Vítor M.; Cruz, Carla; Queiroz, João A.; Pichon, Chantal; Correia, Ilídio J.; Sousa, Fani. "Highly selective capture of minicircle DNA biopharmaceuticals by a novel zinc-histidine peptide conjugate". Separation and Purification Technology 174 (2017): 417-424. http://dx.doi.org/10.1016/j.seppur.2016.10.054.
    10.1016/j.seppur.2016.10.054
  65. João Ferreira; Tiago Santos; Patrícia Pereira; Marta C. Corvo; João A. Queiroz; Fani Sousa; Carla Cruz. Corresponding author: Carla Cruz. "Naphthalene amine support for G-quadruplex isolation". The Analyst 142 16 (2017): 2982-2994. https://doi.org/10.1039/C7AN00648A.
    10.1039/C7AN00648A
  66. Santos, Tiago; Carvalho, Josué; Corvo, Marta C.; Cabrita, Eurico J.; Queiroz, J.A.; Cruz, C.. Corresponding author: Cruz, C.. "l-tryptophan and dipeptide derivatives for supercoiled plasmid DNA purification". International Journal of Biological Macromolecules 87 (2016): 385-396. http://dx.doi.org/10.1016/j.ijbiomac.2016.02.079.
    10.1016/j.ijbiomac.2016.02.079
  67. Santos, Tiago; Pereira, Patrícia; Sousa, Fani; Queiroz, João A.; Cruz, Carla. Corresponding author: Cruz, Carla. "Purification of supercoiled G-quadruplex pDNA for in vitro transcription". Separation and Purification Technology 163 (2016): 59-71. http://dx.doi.org/10.1016/j.seppur.2016.02.036.
    10.1016/j.seppur.2016.02.036
  68. Carvalho, Josué; Ferreira, João; Pereira, P.; Coutinho, E.; Guédin, Aurore; Nottelet, Pierre; Salgado, Gilmar F.; et al. Corresponding author: Cruz, C.. "Stabilization of novel immunoglobulin switch regions G-quadruplexes by naphthalene and quinoline-based ligands". Tetrahedron 72 9 (2016): 1229-1237. http://dx.doi.org/10.1016/j.tet.2016.01.022.
    10.1016/j.tet.2016.01.022
  69. Pereira, Patrícia; Cruz, Carla; Queiroz, João A.; Figueiras, Ana; Sousa, Fani. "Analysis of pre-miR-29b binding conditions to amino acids by using a surface plasmon resonance biosensor". Analytical Methods 8 1 (2016): 205-213. http://dx.doi.org/10.1039/c5ay02329g.
    10.1039/c5ay02329g
  70. Ferreira, Soraia; Carvalho, Josué; Valente, Joana F.A.; Corvo, Marta C.; Cabrita, Eurico J.; Sousa, Fani; Queiroz, João A.; Cruz, Carla. Corresponding author: Cruz, Carla. "Affinity analysis and application of dipeptides derived from l -tyrosine in plasmid purification". Journal of Chromatography B 1006 (2015): 47-58. http://dx.doi.org/10.1016/j.jchromb.2015.10.025.
    10.1016/j.jchromb.2015.10.025
  71. Santos, Diana; Medeiros-Silva, João; Cegonho, Sara; Alves, Elisabete; Ramilo-Gomes, Filipa; Santos, Adriana O.; Silvestre, Samuel; Cruz, Carla. Corresponding author: Cruz, Carla. "Cell proliferation effects of calix[4]arene derivatives". Tetrahedron 71 40 (2015): 7593-7599. http://dx.doi.org/10.1016/j.tet.2015.07.077.
    10.1016/j.tet.2015.07.077
  72. Amorim, Lúcia F. A.; Sousa, Fani; Queiroz, João A.; Cruz, Carla; Sousa, Ângela. "Screening ofl-histidine-based ligands to modify monolithic supports and selectively purify the supercoiled plasmid DNA isoform". Journal of Molecular Recognition 28 6 (2015): 349-358. http://dx.doi.org/10.1002/jmr.2449.
    10.1002/jmr.2449
  73. Mota, E.; Sousa, F.; Queiroz, J. A.; Cruz, C.. "Quantitative analysis of the interaction between L-methionine derivative and oligonucleotides". Journal of Biochemistry 157 4 (2014): 261-270. http://dx.doi.org/10.1093/jb/mvu073.
    10.1093/jb/mvu073
  74. Cruz, C.; Sousa, Â.; Mota, É.; Sousa, F.; Queiroz, J.A.. Corresponding author: Cruz, C.. "Quantitative analysis of histamine- and agmatine-DNA interactions using surface plasmon resonance". International Journal of Biological Macromolecules 70 (2014): 131-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904357281&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2014.06.044
  75. Mota, E.; Sousa, F.; Sousa, Â.; Queiroz, J.A.; Cruz, C.. Corresponding author: Cruz, C.. "Molecular recognition of oligonucleotides and plasmid DNA by L-methionine". Journal of Molecular Recognition 27 10 (2014): 588-596. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906888435&partnerID=MN8TOARS.
    10.1002/jmr.2382
  76. Cruz, C.; Boto, R.E.F.; Drzazga, A.K.; Almeida, P.; Queiroz, J.A.. Corresponding author: Cruz, C.. "NMR screening of new carbocyanine dyes as ligands for affinity chromatography". Journal of Molecular Recognition 27 4 (2014): 197-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897606172&partnerID=MN8TOARS.
    10.1002/jmr.2351
  77. Cruz, C.; Sousa, A.; Sousa, F.; Queiroz, João A.. Corresponding author: Cruz, C.. "Affinity analysis between immobilized l-arginine and plasmid isoforms provided by surface plasmon resonance". Analytical Methods 5 7 (2013): 1682. http://dx.doi.org/10.1039/c3ay40213d.
    10.1039/c3ay40213d
  78. Luís, Â.; Cruz, C.; Duarte, A.P.; Domingues, F.. "An alkenylresorcinol derivative from Hakea sericea fruits and their antimicrobial activity". Natural Product Communications 8 10 (2013): 1459-1462. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886771135&partnerID=MN8TOARS.
  79. Cruz, Carla; Cairrao, Elisa; Lourenco, Olga; Almeida, Paulo; Verde, Ignacio; Queiroz, Joao A.. Corresponding author: Cruz, Carla. "Polyazamacrocycles as Potential Antitumor Agents for Human Prostate Cancer Cells". Chemical Biology & Drug Design 81 4 (2013): 517-526. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000316915200010&KeyUID=WOS:000316915200010.
    10.1111/cbdd.12098
  80. Cruz, Carla; Santos, Sandra D.; Cabrita, Eurico J.; Queiroz, Joao A.. Corresponding author: Cruz, Carla. "Binding analysis between L-histidine immobilized and oligonucleotides by SPR and NMR". International Journal of Biological Macromolecules 56 (2013): 175-180. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000318142300026&KeyUID=WOS:000318142300026.
    10.1016/j.ijbiomac.2013.02.012
  81. Gaspar, Vitor M.; Cruz, Carla; Queiroz, Joao A.; Pichon, Chantal; Correia, Ilidio J.; Sousa, Fani. "Sensitive Detection of Peptide-Minicircle DNA Interactions by Surface Plasmon Resonance". Analytical Chemistry 85 4 (2013): 2304-2311. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000315326900049&KeyUID=WOS:000315326900049.
    10.1021/ac303288x
  82. Cruz, C.; Sousa, A.; Sousa, F.; Queiroz, J. A.. Corresponding author: Cruz, C.. "Study of the specific interaction between L-methionine chromatography support and nucleotides". Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 909 (2012): 1-5. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000311764400001&KeyUID=WOS:000311764400001.
    10.1016/j.jchromb.2012.09.037
  83. Cruz, Carla; Cabrita, Eurico J.; Queiroz, Joao A.. Corresponding author: Cruz, Carla. "Screening nucleotide binding to amino acid-coated supports by surface plasmon resonance and nuclear magnetic resonance". Analytical and Bioanalytical Chemistry 401 3 (2011): 983-993. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000292970200022&KeyUID=WOS:000292970200022.
    10.1007/s00216-011-5124-y
  84. Cruz, Carla; Cabrita, Eurico J.; Queiroz, Joao A.. Corresponding author: Cruz, Carla. "Analysis of nucleotides binding to chromatography supports provided by nuclear magnetic resonance spectroscopy". Journal of Chromatography A 1218 22 (2011): 3559-3564. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000291132600020&KeyUID=WOS:000291132600020.
    10.1016/j.chroma.2011.03.055
  85. Cruz, Carla; Cairrao, Elisa; Silvestre, Samuel; Breitenfeld, Luiza; Almeida, Paulo; Queiroz, Joao A.. Corresponding author: Cruz, Carla. "Targeting of Mitochondria-Endoplasmic Reticulum by Fluorescent Macrocyclic Compounds". Plos One 6 11 (2011): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000297789900008&KeyUID=WOS:000297789900008.
    10.1371/journal.pone.0027078
  86. Cruz, Carla; Boto, Renato E. F.; Almeida, Paulo; Queiroz, Joao A.. Corresponding author: Cruz, Carla. "Study of specific interaction between nucleotides and dye support by nuclear magnetic resonance". Journal of Molecular Recognition 24 6 (2011): 975-980. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000298599500009&KeyUID=WOS:000298599500009.
    10.1002/jmr.1144
  87. Cruz, Carla; Martin, M. Teresa; Kremer, Leonor; Cabrita, Eurico J.; Queiroz, Joao A.. Corresponding author: Cruz, Carla. "Characterisation of homo-oligonucleotide binding to immobilized amino acids using STD-NMR and SPR spectroscopy". Journal of Biotechnology 150 (2010): S200-S200. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000288873401181&KeyUID=WOS:000288873401181.
    10.1016/j.jbiotec.2010.09.003
  88. Sousa, F.; Cruz, C.; Queiroz, J. A.. "Amino acids-nucleotides biomolecular recognition: from biological occurrence to affinity chromatography". Journal of Molecular Recognition 23 6 (2010): 505-518. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000284022700002&KeyUID=WOS:000284022700002.
    10.1002/jmr.1053
  89. Cruz, Carla; Calisto, Vania; Delgado, Rita; Felix, Vitor. "Design of Protonated Polyazamacrocycles Based on Phenanthroline Motifs for Selective Uptake of Aromatic Carboxylate Anions and Herbicides". Chemistry-a European Journal 15 13 (2009): 3277-3289. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000264674300028&KeyUID=WOS:000264674300028.
    10.1002/chem.200800993
  90. Cruz, Carla; Delgado, Rita; Drew, Michael G. B.; Felix, Vitor. "Evaluation of the binding ability of a novel dioxatetraazamacrocyclic receptor that contains two phenanthroline units: Selective uptake of carboxylate anions". Journal of Organic Chemistry 72 11 (2007): 4023-4034. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000246570200005&KeyUID=WOS:000246570200005.
    10.1021/jo062653p
  91. David, S.; Barros, V.; Cruz, C.; Delgado, R.. "In vitro effect of free and complexed indium(III) against Mycobacterium tuberculosis". Fems Microbiology Letters 251 1 (2005): 119-124. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000232194100017&KeyUID=WOS:000232194100017.
    10.1016/j.femsle.2005.07.044
  92. Cruz, C.; Delgado, R.; Drew, M. G. B.; Felix, V.. "Supramolecular aggregates between carboxylate anions and an octaaza macrocyclic receptor". Organic & Biomolecular Chemistry 2 20 (2004): 2911-2918. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000224420700008&KeyUID=WOS:000224420700008.
    10.1039/b412059k
  93. Cruz, C.; Carvalho, S.; Delgado, R.; Drew, M. G. B.; Felix, V.; Goodfellow, B. J.. "Metal complexes of a dipyridine octaazamacrocycle: stability constants, structural and modelling studies". Dalton Transactions 16 (2003): 3172-3183. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000184935200005&KeyUID=WOS:000184935200005.
    10.1039/b304381a
  94. Carvalho, S.; Cruz, C.; Delgado, R.; Drew, M. G. B.; Felix, V.. "Dinuclear copper and zinc complexes of a hexaazamacrocycle containing p-xylyl spacers and bridging anions: theoretical and spectroscopic studies". Dalton Transactions 22 (2003): 4261-4270. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000186367800014&KeyUID=WOS:000186367800014.
    10.1039/b306486g
Thesis / Dissertation
  1. Cruz, Carla. "Study of synthetic receptors in molecular recognition of anionic substrates and metal ions". PhD, Universidade de Aveiro, 2009.

Intellectual property

Patent
  1. Carla Cruz. 2022. "Molecular detection method for SARS-CoV-2 RNA". Portugal.
  2. Cruz, Carla. 2015. "Isolamento de um novo alquil-resorcinol com actividade anti-microbiana a partir dos frutos de Hakea sericea Schrader". Portugal.
    Granted/Issued
  3. Cruz, Carla. 2012. "Método para a marcação da mitocôndria e do retículo endoplasmático utilizando compostos macrocíclicos fluorescentes". Portugal.
    Granted/Issued
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/12/02 G-quadruplexes: a promising target for cancer therapy G-quadruplex international webinar seminars, 2th December, 2021, online.
2021/05/08 Targeted delivery of therapeutic molecules by G-quadruplex aptamers to cervical cancer cells XI Congress Biomedical Sciences
2020/11/03 A breakthrough transatlantic project in the area of cancer treatment, DREAM - Drug delivery nanosysteM for HPV infection therapy Science and Technology Summit in Portugal - Ciência 2020
2020/10/10 Microfluidic assay based on G-quadruplex aptamer for nucleolin detection in prostate cancer XV Annual CICS-UBI symposium 2020
2020/02/04 Nucleolin as a potential cancer biomarker: an applied perspective in Health Biotechnology World Cancer Day 2020 seminars
Centro Hospitalar Cova da Beira
2019/11/14 Human Papillomavirus G-Rich Regions as Potential Targets For Antiviral Drug Development. III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer
Universidade da Beira Interior
2019/11/10 Nucleolin detection for diagnosis of prostate cancer 2nd Portuguese Symposium on Research and Innovations in Urology
Porto Business School
2019/11/10 AS1411 Derived Molecular Beacon to Nucleolin Detection 2nd Portuguese Symposium on Research and Innovations in Urology
2019/10/15 G-quadruplexes Nanosystems for Cancer Therapy FIRST CA17140 COST CONFERENCE Cancer Nanomedicine – from the Bench to the Bedside
Bellevue Park Hotel Riga
2019/09/22 miR-149 G-quadruplex recognition by the nucleolin protein in prostate cancer cells PTNMR meeting - SMASH conference 2019
2019/07/08 G-quadruplexes for cancer diagnosis and therapy Meeting with Science and Technology in Portugal 2019
Fundação para a Ciência e Tecnologia (Lisbon, Portugal)
2019/07/05 Aptamer-based Targeted Delivery of a G-quadruplex Ligand in Cervical Cancer Cells XIV Annual CICS-UBI Symposium
2019/06/20 AS1411 aptamer-conjugated polymeric micelle for the delivery of antiviral and anticancer agents 6th Nano Today Conference
2018/12/02 Development of G-quadruplex mediated HPV antiviral drugs, Eurogin 2018
2018/10/01 BIOmedical DEVICE development based on pre-miRNA G-quadruplex 2018 MIT Portugal Annual Conference
Culturgest - Auditório Pequeno - Lisbon (Portugal)
2018/07/05 Nucleolin-targeted G-quadruplex aptamer as a drug delivery system for cervical cancer cells XIII Annual CICS-UBI Symposium
2018/06/09 Circulating nucleolin as a potential biomarker for canine tumours. XXIII Meeting of the Portuguese Society of Animal Pathology
(Covilha, Portugal)
2018/03/03 Nucleolin as target of RNA G-quadruplex aptamer for prostate cancer diagnosis 6th National Meeting of Chemistry Students
2017/05/17 Fluorescent Acridine Orange derivatives bind and stabilize KRAS-22RT G-quadruplex II International Congress in Health Sciences Research
2017/01/11 Acridine Orange derivatives as G-quadruplex ligands V Ciclo de Conferências da Faculdade de Ciências
(Portugal)
2016/07/02 Screening of L-tryptophan and dipeptide derivatives as ligands for affinity chromatography XI Annual CICS-UBI Symposium
2016/06/11 Targeting G-quadruplexes: Novel Indole-based Ligands XI Annual CICS-UBI Symposium
2016/05/18 NMR Structure and Ligand Binding of a new G-Quadruplex Forming Sequence within the KRAS Promoter Region ANNA 2016
2015/09/02 Phenantroline dioxazole as potential G-quadruplex ligand for cancer therapy International Symposium on Synthesis and Catalysis - ISySyCat 2015
2015/07/02 Biosynthesis of a G-quadruplex- forming sequence and its stabilization by naphthalene-based ligands. Annual CICS-UBI Symposium
2015/07/01 Production and purification of DNA G-quadruplex using pPH600 plasmid X Annual CICS-UBI Symposium
2015/04/02 G-quadruplex-forming sequence production and stabilization III Conferences of Chemistry and Biochemistry
2015/04/01 Synthesis and characterization of novel naphthalene and quinoline-based G-quadruplex ligands for cancer therapy I Congress in Health Sciences Research: Towards Innovation and Entrepreneurship
2013/12/06 Understanding affinity chromatography ligands-nucleic acids interactions Micro Biotech13 - Portuguese Congress of Microbiology and Biotechnology
2013/09/23 Study of the interaction between immobilized L-methionine and oligonucleotides by chromatography, STD-NMR and SPR analysis 19th International Symposium on Separation Sciences
2011/11/14 Analysis of nucleotide binding to affinity chromatography support Modern Methods of Structure Elucidation
2011/06/16 Comprehensive Study of the Interactions Between Nucleotides and Chromatography Supports Provided by STD-NMR Spectroscopy 19th Biennial Meeting Affinity 2011
2009/06/30 Spectroscopic studies to evaluate the recognition of nucleic acids IV Annual CICS Symposium

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/11/01 - Current Exploring one-hit-multiple-target strategies for Lung Cancer
Supervisor
 Bioquímica (PhD)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/09/01 - Current Identification of the G-quadruplex structure present in pre-mir150 in lung cancer cell lines
Supervisor
 Biotecnologia (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/09/01 - Current New Scaffolds for the Design of G-Quadruplex Ligands
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/03/01 - Current Pos-doctoral PTNMR NMR technician for CICS-UBI
Supervisor
 PhD Engenharia Química (Other)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/01/09 - Current Detection of circulating miRNA-155 for lung cancer diagnosis
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/01/02 - Current Determination of the expression of a circulating microRNA in plasma and / or peripheral blood mononuclear cells as a potential biomarker for the diagnosis of non-small cell lung cancer
Supervisor
 Master in Biomedical Sciences (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/01/01 - Current B-MYB G-quadruplex motif as a therapeutic strategy for Non-Small Cell Lung Cancer
Supervisor
 PhD in Biochemistry (PhD)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020/11/01 - Current Novel Aptamer-guided Liposomes for Human Papillomavirus Related Malignant Lesions
Supervisor
 PhD in Biomedicine (PhD)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020/09/01 - Current Formulation of nanoparticles for lung cancer therapy
Supervisor
 Master Biomedical Sciences (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020/01/01 - Current G-quadruplex miR-150 RNA aptamer evaluation for cancer therapy
Supervisor
 Chemistry (PhD)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/01/01 - Current miR-150 G-quadruplex targeting by ligands as a therapeutic strategy for Non-Small Cell Lung Cancer
Supervisor
 PhD Chemistry (PhD)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2018/10/01 - Current miRNA identifying chip for Lung Cancer Diagnosis
Supervisor
 Biochemistry (PhD)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/01/01 - Current NMR metabolomic analysis of cardiovascular disease risk in elderly
Co-supervisor
 Pharmaceutical Sciences (PhD)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2016/01/01 - Current Target da Nucleolina por aptameros do G-quadruplex para terapia do cancro do colo do útero
Supervisor
 Biomedicine (PhD)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/09/01 - 2023/01/15 Development of aptamer nanoparticles for retinal pathologies
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/07/01 - 2022/11/04 Development of RNA-based nanoparticles for cancer therapy
Supervisor
 Master in Biomedical Sciences (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/01/01 - 2022/10/07 Recognition of G-quadruplexes in microRNA precursors by nucleolin and its implications in cancer
Supervisor
 Biomedicine (PhD)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/08/01 - 2021/12/31 PTNMR - NMR technician for CICS-UBI
Supervisor
 Bioquimica (Other)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020/09/01 - 2021/11/18 Detection of microRNAs for diagnosis of non-small cell lung cancer
Supervisor
 Master in Biotechnology (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020/01/01 - 2021/03/03 Development of drug delivery formulations for the treatment of cancerous lesions caused by the Human Papilloma Virus
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/09/01 - 2021/02/19 Screening of novel protein A ligands by surface plasmon resonance for antibody capture
Co-supervisor
 Biotecnologia (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/02/01 - 2020/12/15 G-quadruplex aptamers for cervical cancer therapy
Supervisor
 PhD Biomedicine (PhD)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/07/01 - 2020/07/04 G-Quadruplex Aptamer Beacon for Detection of Prostate Cancer Biomarker
Supervisor
 Master in Biotechnology (Master)
2019/01/04 - 2019/11/15 Biomedical device development based on pre-miRNA G-quadruplex
Supervisor
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/03/01 - 2019/06/30 Produção e purificação da proteína nucleolina e sua utilização no diagnóstico do cancro da próstata
Supervisor
 Biotecnologia (Degree)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/03/01 - 2019/06/30 Desenvolvimento de nanossistemas baseados em RNA G-quadruplex para terapia do cancro do pulmão
Supervisor
 Biotecnologia (Degree)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/03/01 - 2019/06/30 Study of the effect of solvent on the formulation of functionalized micelles with aptamers
Supervisor
 Bioquímica (Degree)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/02/02 - 2019/06/30 Identificação da nucleolina como um potencial biomarcador tumoral do cancro da próstata
Supervisor
 Medicine (Specialization course)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/02/02 - 2019/06/30 Avaliação da expressão de nucleolina em tecidos com lesão pré-cancerosa induzida por HPV
Supervisor
 Medicine (Specialization course)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/07/05 - 2018/10/21 Avaliação da atividade anticancerígena de aptameros de DNA para terapia do cancro do colo do útero
Supervisor
 Biochemistry (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/09/01 - 2018/10/12 Produção e purificação do pre-miRNA-149 com potencial aplicação no diagnóstico do cancro da próstata
Supervisor
 Biotechnology (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/07/04 - 2018/10/10 Nanosistema de entrega de fármacos para o tratamento de infeções por HPV
Supervisor
 Biochemistry (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/09/01 - 2018/10/07 Molecular Modelling of a novel G-quadruplex structure and its interaction with ligands
Supervisor
 Biomedical Sciences (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/06/01 - 2018/10/06 Nanosistema de entrega de fármacos para o tratamento de infeções por HPV
Supervisor
 Biomedical Sciences (Master)
Universidade da Beira Interior Centro de Investigação em Sistemas Electromecatrónicos, Portugal
2017/06/01 - 2017/07/31 G-quadruplex aptamers for cervical cancer therapy: structure, function and application
Supervisor
 Medicine (Specialization course)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/06/01 - 2017/07/31 G-quadruplex aptamers for cervical cancer therapy
Supervisor
 Medicine (Specialization course)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/06/01 - 2017/07/30 G-quadruplex ligands target cancer therapy
Supervisor
 Medicine (Specialization course)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/01/04 - 2017/07/05 Optimização do aptamero AS411 com aumento da afinidade para células cancerígenas
Supervisor
 Biotechnology (Degree)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/01/01 - 2017/07/05 Conjugação de aptameros a agentes de escape endossomal para entrega de fármacos
Supervisor
 Biochemistry (Degree)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/09/01 - 2016/09/02 Desenvolvimento de transportadores de fatores neuroprotectores derivados de macrociclos permeáveis à barreira hematoencefálica
Co-supervisor
 Biochemistry (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2016/01/01 - 2016/07/04 Aptameros de G-quadruplex radiomarcados para detecção de células cancerígenas infectadas por HPV
Supervisor
 Biochemistry (Degree)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/10/01 - 2015/12/31 Technologies for purification and controlled release of biopharmaceuticals to be applied in age-related diseases
Supervisor
 postdoctoral in Biochemistry (Other)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/01/01 - 2015/12/31 Purification of Biopharmaceuticals
Supervisor
 Biochemistry (Scientific initiation)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/07/06 - 2015/11/04 Síntese e avaliação biológica de poliaminoamidas esteroides antitumorais que interagem com o G-quadruplex
Co-supervisor
 Biochemistry (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/09/04 - 2015/11/03 Síntese de ligandos do G-quadruplex e sua avaliação em células cancerígenas
Co-supervisor
 Biomedical Sciences (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/07/02 - 2015/11/02 Terapia Génica Mitocondrial Desenvolvimento de um vetor com afinidade pela mitocôndria
Co-supervisor
 Biotechnology (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/09/01 - 2015/11/01 Desenvolvimento de suportes cromatográficos derivados de compostos heterocíclicos para purificação de plasmídeos contento fragmentos de G-quadruplex
Supervisor
 Biotechnology (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/07/05 - 2015/10/05 Síntese de ligandos do G-quadruplex e sua avaliação em células cancerígenas
Supervisor
 Biomedical Sciences (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/07/04 - 2015/10/03 Purificação do plasmídeo pVAX-G4 utilizando suportes cromatográficos derivados de compostos heterocíclicos
Supervisor
 Biotechnology (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/05/01 - 2015/09/03 G-4 ligands for cancer therapy
Supervisor
 Biochemistry (Master)
Universidade Nova de Lisboa, Portugal
2014/06/01 - 2015/07/05 Biosynthesis of a G-Quadruplex—forming sequence and its stabilization by ligands
Supervisor
 Biotechnology (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/06/01 - 2015/07/04 Produção e purificação do DNA G-quadruplex utilizando o plasmídeo pPH600
Supervisor
 Biotechnology (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/01/01 - 2015/07/02 Produção de DNA quadruplex isotopicamente marcado para estudos de interação com polioxazóis
Supervisor
 Biochemistry (Degree)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/06/01 - 2014/12/31 G-quadruplex binders for cancer therapy
Supervisor
 Biochemistry (Scientific initiation)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/03/01 - 2014/12/31 G-quadruplex binders for cancer therapy
Supervisor
 Pharmaceutical Sciences (Scientific initiation)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/09/01 - 2014/11/02 Study of the interactions between intercalators and pDNA for molecular therapy
Supervisor
 Biotechnology (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/09/01 - 2014/10/02 Estudo de novos ligandos para purificação de ácidos nucleicos
Supervisor
 Biomedical Sciences (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/09/01 - 2014/10/01 Desenvolvimento de novos potenciais anticancerígenos com ação no G-quadruplex
Supervisor
 Biotechnology (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/09/01 - 2014/10/01 Desenvolvimento de novos suportes cromatográficos para purificação do DNA plasmídico Biotecnology (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/07/01 - 2014/07/02 Purification of supercoiled HPV-16 E6/E7 plasmid using a modified monolithic support
Co-supervisor
 Biomedical Sciences (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2012/09/01 - 2013/08/31 Project in Chemistry, fellowship SWG - Ciência sem fronteiras, Process: 237613/2012-3
Supervisor
 Chemistry (Scientific initiation)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/01/01 - 2013/07/07 Expressão e purificação da proteína b-amilóide humana isotopicamente marcada com 15N e 13C para estudos estruturais de RMN
Supervisor
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/01/01 - 2013/07/04 Estudos por RMN da estabilidade de complexos do quadruplex com porfirinas
Supervisor
 Biotechnology (Degree)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2012/01/03 - 2012/07/04 Síntese de compostos macrocíclicos para aplicação na terapia do cancro
Supervisor
 Biochemistry (Degree)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2012/01/01 - 2012/07/04 Reconhecimento molecular de ADN telomérico humano por fármacos utilizando o biosensor óptico
Supervisor
 Biotechnology (Degree)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2012/01/01 - 2012/07/01 Reconhecimento molecular de estruturas de DNA quadruplex por fármacos anti-cancerígenos
Supervisor
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2012/01/02 - 2012/06/05 Estudos de interacção entre estruturas de DNA quadruplex e fármacos anti-cancerígenos por Ressonância Magnética Nuclear
Supervisor
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/05/05 - Current Hands-on NMR-based Metabolomics: principles, methods and applications (2022/05/05)
Meeting (President of the Organising Committee)
2021/09/07 - Current XVI Annual CICS-UBI Symposium (2021/09/07)
Symposium
2019/11/14 - Current III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer (2019/11/14)
Conference (Member of the Organising Committee)
2018/07/05 - Current XIII Annual CICS-UBI symposium 2018 (2018/07/05)
Symposium (Member of the Scientific Committee)
2020/10/01 - 2020/10/02 XV ANNUAL CICS-UBI SYMPOSIUM 2020 (2020/10/01)
Symposium (Member of the Scientific Committee)
2020/04/28 - 2020/04/30 Hands-on in metabolomics using NMR (2020/04/28 - 2020/04/30)
Other (President of the Organising Committee)
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2018/09/21 - 2018/09/21 Lab-on-chip platforms for chemical and biological analysis. João Pedro Conde Professor Catedrático Department of Bioengineering, Instituto Superior Técnico University of Lisbon and INESC Microssistemas e Nanotecnologias (2018/09/21 - 2018/09/21)
Seminar (President of the Organising Committee)
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2018/04/21 - 2018/04/21 DNA-targeted Metalloconjugates for Cancer Theranostics. António Paulo, Investigador Principal no Instituto Superior Técnico Radiopharmaceutical Sciences and Health Physics - Centro de Ciências e Tecnologias Nucleares (2018/04/21 - 2018/04/21)
Seminar (President of the Organising Committee)
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2016/01/07 - 2016/01/09 NMR Applications to Biological Systems (2016/01/07 - 2016/01/09)
Symposium (President of the Organising Committee)
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/02/10 - 2014/02/14 2ª edition NMR - from theory to practice (2014/02/10 - 2014/02/14)
Symposium (President of the Organising Committee)
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/06/25 - 2013/06/27 Metabonomics NMR course: from theory to pratice Dr. Fang Fang e Dr. Eberhard Humpfer (2013/06/25 - 2013/06/27)
Symposium (President of the Organising Committee)
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2012/02/13 - 2012/02/17 Hands on course, NMR - From Theory to Practice (2012/02/13 - 2012/02/17)
Symposium (President of the Organising Committee)
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2011/05/05 - 2011/05/05 Ligand-Based NMR Interaction Studies (2011/05/05 - 2011/05/05)
Seminar (President of the Organising Committee)
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/02/04 - Current World Cancer Day 2022 - Round Table online with CICS-UBI Researchers
Round table
 World Cancer Day 2022

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/06/01 Strategies for reducing the allergenicity of hen egg by treatment with natural antioxidants
Thesis Member
 Alcides Vapor (PhD)
Universidade da Beira Interior, Portugal
2021/11/17 Design of Deep Eutectic Solvents to improve RNA stabilization and storage
(Thesis) Main arguer
 Ana Isabel da Silva Pereira Ferro (Master)
Universidade da Beira Interior, Portugal
2021/02/25 Novel Excipient Candidates for RNA Stabilization
(Thesis) Main arguer
 Sofia Pereira Oliveira (Master)
2018/12/06 Estudos de interação de porfirinas e ftalocianinas catiónicas com ADN
(Thesis) Main arguer
 Susana Pinho de Almeida (Master)
Universidade de Aveiro, Portugal
2017/07/05 Marcadores Genéticos no cancro do pâncreas
(Thesis) Main arguer
 David Carriço Teixeira (Other)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/06/04 Desenvolvimento de sistemas de entrega de fármacos inovadores
(Thesis) Main arguer
 Cláudia Dias da Silva (Other)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2016/10/08 Desenvolvimento de Esteroides Funcionalizados Nos Anéis A e D Como Potenciais Agentes Anti-Alzheimer
(Thesis) Main arguer
 Jessica Patrícia Melo Ribeiro (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/06/05 Ressonância magnética no diagnóstico do cancro da mama
(Thesis) Main arguer
 Catarina Chendo (Other)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/09/05 A oxidação de álcoois esteroides na preparação de compostos bioativos e seus intermediários sintéticos
(Thesis) Main arguer
 Filipa João Fernandes Ramilo Gomes (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/07/05 Caracterização de fatores de risco para a Doença Cardiovascular, em Pré-diabéticos e Diabéticos, numa amostra populacional da Cova da Beira
Thesis Member
 Diana Inês Mota Gaspar (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/07/04 Efeito da Testosterona na compartimentação do cGMP a nível vascula
Thesis Member
 Joana Rita Oliveira Feiteiro (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/06/05 Será que a maquinaria de transdução olfativa está presente no intestino
Thesis Member
 Carla Filipa Costa (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/06/02 Understanding ion-exchange adsorption mechanism under overloaded conditions
Thesis Member
 Gonçalo Fradique Lopes da Silva (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2011/07/05 Extracção e purificação de proteínas do vinho
(Thesis) Main arguer
 Carla Gomes (Other)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2011/07/02 Avaliação da qualidade e origem do tomate por FT-IR
(Thesis) Main arguer
 Ana Afonso (Other)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2021/02/01 - Current Molecular Therapy - Nucleic Acids
2020/04/04 - Current Sensors & Actuators: B. Chemical
2020/01/02 - Current Nanoscale
2019/02/01 - Current Int. J. Mol. Sci.
2019/02/01 - Current FEBS LETTERS
2019/02/01 - Current International Journal of Nanomedicine
2019/01/01 - Current Molecules
2018/02/01 - Current Nucleic Acids Therapeutics
2018/02/01 - Current Molecular Pharmaceutics
2018/01/01 - Current Nucleic Acids Research
2017/04/01 - Current ChemBioChem
2017/02/01 - Current ChemEurJ
2012/02/02 - Current BBA - General Subjects
2012/01/02 - Current Protein Letters
2012/01/01 - Current Bioconjugate Chemistry
2011/04/01 - Current Scientific Reports
2011/01/01 - Current Physical Chemistry Chemical Physics
2010/01/01 - Current Dalton Transactions
2009/01/01 - Current Chemical Communications
2009/01/01 - Current Organic & Biomolecular Chemistry

Committee member

Activity description
Role 		Institution / Organization
2022/07/01 - Current European infrastructure for translational medicine - EATRIS- Small Molecules plataform
Member
2021/12/01 - Current COST Member Expert to evaluate scientific activities related to the COST (European Cooperation in Science and Technology)
Member
2021/12/01 - Current Member of European Association for Cancer Research, EACR32133
Member
 European Association For Cancer Research, United Kingdom
2021/11/14 - Current Coordinator Ciencia Aberta FCT at CICS-UBI
Coordinator
2021/11/11 - Current Coordinator of the Biopharmaceuticals and Biomaterials Group at Health Sciences Research Center (CICS) -University of Beira Interior (UBI)
Coordinator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/11/02 - Current Member of Committee of Thesis Biochemistry -University of Beira Interior
Member
 Universidade da Beira Interior, Portugal
2021/11/01 - Current Member of Committee of Thesis Biomedicine- University of Beira Interior
Member
 Universidade da Beira Interior, Portugal
2021/09/07 - Current XVI Annual CICS-UBI Symposium
Member
2021/02/15 - Current Cancer Mission International Brokerage Turquia
Member
2021/01/02 - Current Erasmus+ Evaluator
Member
 Erasmus Plus, Belgium
2020/10/01 - Current XV Annual CICS-UBI Symposium
Member
2020/09/01 - Current Member WP1 da COST Action -Delivery of Antisense RNA Therapeutics (DARTER), Ref. CA17013
2020/03/01 - Current Member of Committee of Thesis - A microfluidic platform for rapid detection of antibiotic resistant bacteria at the point-of-need,
Member
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/11/15 - Current Ciência Vitae Promotor at FCT
Advisor / Consultant
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/11/01 - Current Member of the Executive Comission of Health Sciences Research Centre (CICS-UBI)
Member
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/02/01 - Current COST Action CA17140: Nano2Clinic Cancer Nanomedicine - from the bench to the bedside
Member
2018/09/28 - Current Member of Management Committee COST Action CA17140 Cancer nanomedicine - from the bench to the bedside
Member
 European Cooperation in Science and Technology, Belgium
2017/09/15 - Current Coordinator of Biomedicine and Pharmaceutical Sciences 3rd Cycle Degree Clinical Rotations I/II.
Coordinator
2015/01/01 - Current Group Leader of the G-quadruplex Group at CICS-UBI : https://gquadruplex.wixsite.com/ccruz
Coordinator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/11/01 - 2021/10/30 Vice-Coordinator of reseach group Biopharmaceuticals and Biomaterials at Health Sciences Research Centre (CICS-UBI) https://www.ubi.pt/Sites/cics/en/Pagina/about#organization
President / Vice-president
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/11/01 - 2021/10/30 Coordinator of Funding and Internationalization Comission at Health Sciences Research Centre (CICS-UBI)
Coordinator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2009/06/01 - 2012/12/31 COST Action MP0802 - "Self-Assembled Guanosine Structures for Molecular Electronic Devices"
Member
 European Cooperation in Science and Technology, Belgium

Conference scientific committee

Conference name Conference host
2020/10/01 - Current ANNUAL CICS-UBI SYMPOSIUM 2020
2019/11/15 - Current III International Congress in Health Sciences Research Universidade da Beira Interior
2018/04/07 - 2018/04/10 Anais do 5º Encontro Regional de Química & 4º Encontro Nacional de Química Editora Edgard Blücher
2017/05/17 - 2017/05/20 II International Congress in Health Sciences Research

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/03/01 - Current Bioquímica II Bioquímica (Licenciatura) Universidade da Beira Interior Faculdade de Ciências, Portugal
2022/03/01 - Current Cursos Avançados II Biomedicina (Doutoramento) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2020/02/15 - Current Drug Development and Synthesis Ciências Farmacêuticas (Mestrado integrado) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/09/15 - Current Introdução às Ciências Biomédicas (códigos 8361 TP1-TP3 Biomedical Sciences (Licenciatura) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/02/19 - Current Seminário (códigos 8396 OT1-OT3 e SE1-SE3) Biomedical Sciences (Licenciatura) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2011/03/02 - Current Rotações Laboratoriais I and II Biomedicine , Pharmaceutical Sciences and Biochemistry (Doutoramento) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2010/04/02 - Current Estrutura e Função das Proteínas Biochemistry, Biotechnology and Medicinal Chemistry (Mestrado) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2010/04/03 - 2015/07/05 Biologia Vegetal Biochemistry and Biotechnology (Licenciatura) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2010/03/02 - 2011/04/05 Corpo Humano: dos Sistemas às Moléculas I Medicine (Mestrado integrado) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/10/22 - Current One Health room, XVII International Montenegro Veterinary Congress 2021
Other
2021/06/27 - Current Evaluator of research projects from QNRF - Qatar National Research Fund
Evaluator
 Qatar National Research Fund, Qatar
2020/01/02 - Current Evaluator of research projects from National Center of Science and Technology, Republic of Kazakhstan.
Evaluator
2019/11/14 - 2019/11/16 III International Congress in Health Sciences Research
Evaluator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/07/04 - 2019/07/05 XIV ANNUAL CICS-UBI SYMPOSIUM 2019
Evaluator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/03/01 - 2019/03/31 Evaluator of research projects from National Science Center, Poland
Evaluator
2018/07/05 - 2018/07/06 XIII Annual CICS-UBI Symposium Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/05/17 - 2017/05/20 II International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Biotechnology for Biomedical Applications
Evaluator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2020/12/05 Interview published in the supplement Perspetiva Atual newspaper SOL, edition nº5-December 2020 with Principal Investigator Carla Cruz - project Track and Trace COVID-19. Perspetiva Atual jornal SOL
2020/06/29 News / interview published in the supplement Forum Covilha 2020 with Principal Investigator Carla Cross on the project Forum Covilha
2020/04/05 Jornal de Noticias- Project Track and Trace Covid-19
2020/04/04 Jornal Expresso- Project Track and Trace Covid-19 https://expresso.pt/coronavirus/2020-04-22-Universidade-da-Beira-Interior-investiga-imunidade-e-diagnostico-mais-rapido
2020/04/04 Interior- Project Track and Trace Covid-19
2020/04/04 Noticias da Covilhã - Project Track and Trace Covid-19
2020/04/04 journal of University of Beira Interior and CICS webpage - Project Track and Trace Covid-19
2019/10/28 Project DREAM: Using Aptamers to Decrease Side-Effects of Anti-Cancer Drugs -The University of Texas at Austin NEWS Center for systems and Synthetic Biology (CSSB)- The University of Texas at Austin
2019/10/28 University of Texas at Austin- Center for Systems and Synthetic Biology, project UTAPEXPL/ NTec/0015/2017 DREAM site of University of Texas at Austin- Center for Systems and Synthetic Biology
2019/10/09 Exploratory Research team expects to decrease the side effects of anticancer drugs- UTAustin Portugal News UTAustin Portugal News
2019/07/26 Aptamer-based targeted Delivery of a G-quadruplex Ligand in Cervical Cancer Cells Portuguese Association for Cancer Research
2019/07/26 “Aptamerbased targeted Delivery of a G-quadruplex Ligand in Cervical Cancer Cell” Associação Portuguesa de Investigação em Cancro (ASPIC)
2018/01/23 FCT MIT BIOmedical DEVICE development based on pre-miRNA Gquadruplex interview- Jornal do Fundão Jornal do Fundão
2018/01/23 BIOmedical DEVICE development based on pre-miRNA G-quadruplex

Interview (tv / radio show)

Program Topic
2020/04/05 - Current Radio Caria- project Track and Trace Covid-19
2020/04/04 - Current Radio Cova Beira - Project Track and Trace Covid-19
2020/04/04 - Current RTP-noticias - Project Track and Trace Covid-19
2020/04/04 - Current Saúde Mais- Project Track and Trace Covid-19
2020/04/02 - Current Radio da Covilhã- project Track and Trace Covid-19
2019/01/13 - Current 90 segundos de Ciência Antena 1 BIOmedical DEVICE development based on pre-miRNA G-quadruplex
2018/01/23 - Current Rádio Cova da Beira- MIT project "Biomedical device development based on pre-miRNA G-quadruplex" Biomedical device development based on pre-miRNA G-quadruplex
2018/01/04 - Current Radio Cova da Beira - “Development of drug delivery nanocarrier for HPV infection", project FLAD Healthcare 2020 FLAD Healthcare 2020

Journal scientific committee

Journal title (ISSN) Publisher
2021/05/01 - Current Biomolecules mdpi
2021/05/01 - Current Biomedicines
2021/04/01 - Current Cancers mdpi

Other jury / evaluation

Activity description Institution / Organization
2010/01/03 - Current Corday-Morgan Prize attributed by Royal Society of Chemistry - Professor Jonathan Steed from Durham University Royal Society of Chemistry, United Kingdom
Distinctions

Award

2023 Third place in -ARRISCA C Business Ideas Contest, Innovation category
2023 First place in -Concurso de Ideias de Negócio WIN-UBI
Universidade da Beira Interior, Portugal
2023 Second place -UI.CAN –Universidades como Interface para o Empreendedorismo
Universidade de Aveiro, Portugal
2022 Short Term Scientific Mission (STSM) grant COST Action CA17140 Nanomedicine - from the bench to the bedside (NANO2CLINIC) with University Ferrara, Claudio NASTRUZZI
European Cooperation in Science and Technology, Belgium
2021 Short Term Scientific Mission (STSM) grant COST Action CA17140 Nanomedicine - from the bench to the bedside (NANO2CLINIC) with Universidad de Santiago de Compostela
European Cooperation in Science and Technology, Belgium
2021 Short Term Scientific Mission (STSM) grant COST Action CA17140 Nanomedicine - from the bench to the bedside (NANO2CLINIC) with Faculty of Sciences, Chemistry Department, University of Burgos
European Cooperation in Science and Technology, Belgium
2020 1st International Electronic Conference on Biosensors - "Microfluidic Assay Based on G-quadruplex Aptamer for Nucleolin Detection in Prostate Cancer" - Best Poster Award
2020 Targeting Human Papillomavirus Promoter Regions as a Potential Antiviral Strategy - International IPVC 2020 - The 33rd International Papillomavirus Conference - Best Poster Award
2019 III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer - Detection of the potential cancer biomarker nucleolin in a microfluidic system - Best Poster Award
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019 Short Term Scientific Mission (STSM) grant COST Action CA17140 Nanomedicine - from the bench to the bedside (NANO2CLINIC) with Universidad Autónoma de Madrid
European Cooperation in Science and Technology, Belgium
2019 Health Research MSD 2019 - The Biodevice validation for the diagnosis of prostate cancer -Merck Sharp and Dohme
Merck Sharp and Dohme, Australia
2019 Best oral communication award in XIV Annual CICS-UBI Symposium
2017 Best oral communication award" in II International Congress in Health Sciences Research
2017 Best poster communication award in XII Annual CICS-UBI Symposium
2016 Best oral communication award" in XI Annual CICS-UBI Symposium
2015 Best poster communication award in Jornadas de Química e Bioquímica 2015
2011 F7 BiO-NMR - Structural analysis between amino acids affinity ligands and plasmid DNA pGL1-
European Commission Seventh Framework Programme for Research and Technological Development, Belgium
2009 Short Term Scientific Mission (STSM) grant COST Action COST MP0802 - Self-assembled guanosine structures for molecular electronic devices, ref. COST-STSM-MP0802-4788
European Cooperation in Science and Technology, Belgium
2003 Third Prize for the Communication presented at ISMC 2003
XXVIII International Symposium on Macrocyclic Chemistry , Poland