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Maria S. M. Mendes graduated in Biochemistry in 2019 at University of Aveiro, with a final project entitled "Novel systems for the controlled delivery of non-steroidal anti-inflammatory drugs". During this period, she worked with the preparation of deep eutectic solvents (DES) comprising active pharmaceutical ingredients and their incorporation into biopolymer-based drug delivery systems for transdermal administration. This work resulted in oral communications in international conferences and in an original research article. In 2021 at the same institution, she obtained her MSc degree in Biochemistry - Specialization in Clinical Biochemistry, with the Master Thesis final classification of 19 (in a scale of 0-20). Her Master's dissertation was focused on the pretreatment of human fluids using three-phase partitioning systems for the diagnosis and prognosis of lung cancer. She worked as a researcher in the field of Chemical Engineering at the research group "Process and Product Applied Thermodynamics" (PATh), CICECO - Aveiro Institute of Materials, University of Aveiro, Portugal, with a 12-month scholarship under a project funded by the FCT. Currently, she is a PhD student in Chemical Engineering at the University of Aveiro, Portugal. Maria has worked with a diversity of scientific techniques having experience in formulation and characterization of deep eutectic solvents; experience in liquid-liquid extraction with aqueous biphasic systems (ABS); experience in characterization techniques such as Fourier transform infrared (FTIR); experience in quantification techniques such as high-performance liquid chromatography (HPLC) and enzyme-linked immunosorbent assays (ELISA).
Identification

Personal identification

Full name
Maria Silvina Marques Mendes

Citation names

  • Maria S. M. Mendes
  • M. S. M. Mendes
  • Mendes, Maria S. M.
  • Mendes, M. S. M.

Author identifiers

Ciência ID
681E-D4A9-B13B
ORCID iD
0000-0001-6631-9821

Email addresses

  • msilvinamm@ua.pt (Professional)

Addresses

  • Campus Universitário de Santiago, 3810-193, Aveiro, Aveiro, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Engineering and Technology - Chemical Engineering

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
French Upper intermediate (B2) Intermediate (B1) Intermediate (B1) Upper intermediate (B2) Elementary (A2)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2022/10/01 - 2026/12/20
Ongoing
Engenharia Química (Doutoramento)
Major in Engenharia Biotecnológica
Universidade de Aveiro, Portugal
2019/09/12 - 2021/07/23
Concluded
Bioquímica (Mestrado)
Major in Bioquímica Clínica
Universidade de Aveiro, Portugal
"Human fluids pretreatment using three-phase partitioning systems for the diagnosis and prognosis of lung cancer." (THESIS/DISSERTATION)
18
2016/09/13 - 2019/07/02
Concluded
Bioquímica (Licenciatura)
Universidade de Aveiro, Portugal
"Novos sistemas de administração controlada de fármacos anti-inflamatórios não-esteróides." (THESIS/DISSERTATION)
15
2013 - 2016
Concluded
Curso de Ciências e Tecnologias (Ensino secundário)
Escola secundária Aquilino Ribeiro, Portugal
16
Projects

Grant

Designation Funders
2021/11/01 - 2022/10/31 ILSurvive - Integração do pré-tratamento de fluidos humanos e deteção de biomarcadores tumorais utilizando sistemas aquosos bifásicos formados por líquidos iónicos em dispositivos microfluídicos
PTDC/EMD-TLM/3253/2020
Research Fellow
Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference poster
  1. Maria S. M. Mendes; Chu, Virginia; Mara G. Freire; e Silva, Francisca A.; João P. Conde. "Ionic-liquid-based aqueous biphasic systems for improved detection of cancer biomarkers in microfluidic devices". Paper presented in 7th Iberoamerican Meeting on Ionic Liquids, 2024.
  2. Maria S. M. Mendes; Marguerita E. Rosa; Coutinho, Joao A. P.; Mara G. Freire; e Silva, Francisca A.. "Enhanced Quantification of Pentraxin-3 Using Aqueous Biphasic Systems as Serum Pretreatment Strategies". Paper presented in 43rd International Symposium and Exhibit on the Separation, Purification and Characterization of Biologically Important Molecules, 2024.
  3. Maria S. M. Mendes; Marguerita E. Rosa; Coutinho, Joao A. P.; Mara G. Freire; Francisca A. e Silva. "Improved accuracy in pentraxin-3 quantification assisted by aqueous biphasic systems as serum pretreatment strategies". Paper presented in Jornadas do CICECO 2024, 2024.
  4. Cruz, Inês; Maria S. M. Mendes; Hugo Santos; Francisca A. e Silva; Neves, Márcia C.; Mara G. Freire. "Pretreatment of human fluids using alternative adsorbents for diagnostic purposes". Paper presented in Jornadas do CICECO 2024, 2024.
  5. Inês B. Santana; Maria S. M. Mendes; Mara G. Freire; Francisca A. e Silva. "Improving bisphenol A detection in human serum using aqueous biphasic systems". Paper presented in Jornadas do CICECO 2024, 2024.
  6. Inês B. Santana; Maria S. M. Mendes; Mara G. Freire; e Silva, Francisca A.. "Exploring alternative methods for serum pretreatment using aqueous biphasic systems for enhanced biomarker detection". Paper presented in 6th Meeting of Medicinal Biotechnology, 2024.
  7. Inês B. Santana; Maria S. M. Mendes; Mara G. Freire; e Silva, Francisca A.. "Development of alternative serum pretreatment strategies resorting to ionic liquid-based aqueous biphasic systems". Paper presented in VIII meet.Lab Coimbra, 2024.
  8. Maria S. M. Mendes; Maria C. Souza; João P. Conde; Mara G. Freire; e Silva, F. A.. "Novel Platforms For Human Serum Pretreatment and Breast Cancer Biomarkers Extraction Using Ionic Liquid-Based Aqueous Biphasic Systems". Paper presented in Congress of Microbiology and Biotechnology 2023 (MicroBiotech 2023), 2023.
  9. Marguerita E. Rosa; Maria S. M. Mendes; Ana P. M. Tavares; João A. P. Coutinho; Mara G. Freire; e Silva, F. A.. "Application of ionic-liquid-based aqueous biphasic systems in the extraction and purification of prostate-specific antigen from human serum". Paper presented in 7th International Conference on Ionic Liquid-based Materials (ILMAT 2023), 2023.
  10. Maria S. M. Mendes; Maria C. Souza; João P. Conde; Freire, Mara G.; Francisca A. e Silva. "Ionic liquid-based aqueous biphasic systems as efficient approaches for the extraction of a breast cancer biomarker from human serum". Paper presented in Jornadas CICECO 2023, 2023.
  11. Sofia Pedro; Maria S. M. Mendes; Mara G. Freire; Francisca A. e Silva . Corresponding author: Sofia Pedro. "Serum pretreatment using aqueous biphasic systems and solid-phase extraction: promising routes to assist the detection of prostate-specific antigen". Paper presented in Jornadas do CICECO 2023, 2023.
  12. Maria S. M. Mendes; Maria C. Souza; João P. Conde; Mara G. Freire; Francisca A. e Silva. "Development of efficient platforms for breast cancer biomarkers extraction resorting to ionic liquid-based aqueous biphasic systems". Paper presented in 14th International Chemical and Biological Engineering Conference, 2023.
  13. Maria S. M. Mendes; Marguerita E. Rosa; João A. P. Coutinho; Francisca A. e Silva ; Mara G. Freire. Corresponding author: Maria S. M. Mendes. "Detection of pentraxin-3 in human serum assisted by aqueous biphasic systems". Paper presented in Ciência 2023, 2023.
  14. Maria S. M. Mendes; Marguerita E. Rosa; Coutinho, Joao A. P.; Francisca A. e Silva ; Mara G. Freire. "Use of aqueous biphasic systems to improve the detection of pentraxin-3 in human serum". Paper presented in 5 EBTM - Encontro de Biotecnologia Medicinal, 2022.
  15. Maria S. M. Mendes; Marguerita E. Rosa; Coutinho, Joao A. P.; Francisca A. e Silva ; Mara G. Freire. "Enhanced detection of pentraxin-3 in human serum using aqueous biphasic systems as sample pretreatment techniques". Paper presented in Jornadas do CICECO 2022, 2022.
  16. Marguerita E. Rosa; Maria S. M. Mendes; Coutinho, Joao A. P.; Francisca A. e Silva ; Mara G. Freire. Corresponding author: Marguerita E. Rosa. "Human serum pre-treatment and biomarker extraction: ionic liquids as selectivity enhancers of PEG-salt-based three-phase partitioning systems". Paper presented in Jornadas do CICECO 2022, 2022.
  17. Maria S. M. Mendes; Marguerita E. Rosa; Francisca A. e Silva ; Mara G. Freire. "Detection of pentraxin-3 in human serum assisted by aqueous biphasic systems". Paper presented in Biopartitioning & Purification Conference, 2022.
  18. Marguerita E. Rosa; Maria S. M. Mendes; Coutinho, Joao A. P.; Francisca A. e Silva ; Mara G. Freire. "Human serum pretreatment for better cancer biomarkers' detection: using ionic liquids to tune the performance of polymer-salt-based tree-phase partitioning systems". Paper presented in Biopartitioning & Purification Conference, 2022.
  19. Francisca A. e Silva ; Maria S. M. Mendes; Marguerita E. Rosa; Pereira, Matheus M.; Coutinho, Joao A. P.; Mara G. Freire. "Advances achieved in the analysis of serum biomarkers using aqueous biphasic systems". Paper presented in Biopartitioning & Purification Conference, 2022.
  20. Maria S. M. Mendes; Rosa, M.E.; e Silva, F. A.; Mara G. Freire. "Sample preparation using three-phase partitioning systems for accurate detection of pentraxin-3 in human serum". Paper presented in 2nd European Sample Preparation e-Conference (EuSP2022), 2022.
  21. Maria S. M. Mendes; Marguerita E. Rosa; Francisca A. e Silva; Mara G. Freire. "Sample Preparation Using Three-Phase Partitioning Systems for Improved Detection of Pentraxin-3 in Human Serum". Paper presented in 2nd European Sample Preparation and 1st Green and Sustainable Analytical Chemistry e-Conferences, 2022.
  22. M. Sharma; Maria. S. M. Mendes; A. P. M. Tavares; N. Singh; D. Mondal; Neves, Márcia C.; K. Prasad; Mara G. Freire. "Purification of immunoglobulin G antibodies using hybrid alginate-protein cryogel beads". Paper presented in 40th International Symposium on the Separation of Proteins, Peptides & Polynucleotides, 2021.
  23. Maria. S. M. Mendes; Rosa, M.E.; e Silva, F. A.; Mara G. Freire. "Improved detection of lung cancer biomarkers using three-phase partitioning systems as human serum pretreatment techniques". Paper presented in Jornadas CICECO 2021, 2021.
Journal article
  1. Rosa, Marguerita E.; Mendes, Maria S.M.; Belchior, Diana C.V.; Coutinho, João A.P.; e Silva, Francisca A.; Freire, Mara G.. "Enhancing biomarker detection in human serum for lung cancer diagnosis: Aqueous biphasic systems for simultaneous depletion of high-abundance proteins and efficient extraction of CYFRA 21–1". Advances in Sample Preparation 10 (2024): 100116. http://dx.doi.org/10.1016/j.sampre.2024.100116.
    Accepted • 10.1016/j.sampre.2024.100116
  2. Maria S. M. Mendes; Marguerita E. Rosa; Coutinho, Joao A. P.; Mara G. Freire; Francisca A. e Silva. "Improved accuracy in pentraxin-3 quantification assisted by aqueous biphasic systems as serum pretreatment strategies". International Journal of Biological Macromolecules 253 8 (2023): 127540.
    Published
  3. Marguerita E. Rosa; Maria S. M. Mendes; Eduarda Carmo; João P. Conde; Coutinho, Joao A. P.; Mara G. Freire; Francisca A. e Silva . Corresponding author: Marguerita E. Rosa. "Tailored pretreatment of serum samples and biomarker extraction afforded by ionic liquids as constituents of aqueous biphasic systems". Separation and Purification Technology 322 (2023): 124248.
    Published
  4. Pedro, Sónia N.; Mendes, Maria S. M.; Neves, Bruno M.; Almeida, Isabel Filipa; Costa, Paulo; Correia-Sá, Inês; Vilela, Carla; et al. "Deep Eutectic Solvent Formulations and Alginate-Based Hydrogels as a New Partnership for the Transdermal Administration of Anti-Inflammatory Drugs". Pharmaceutics 14 4 (2022): 827. http://dx.doi.org/10.3390/pharmaceutics14040827.
    Published • 10.3390/pharmaceutics14040827
Newspaper article
  1. Maria S. M. Mendes; Marguerita E. Rosa; Fábio Ramalho; Mara G. Freire; Francisca A. e Silva. "Aqueous two-phase systems as multipurpose tools to improve biomarker analysis", Separation and Purification Technology, 2023, https://www.sciencedirect.com/science/article/pii/S1383586623007839.
    https://doi.org/10.1016/j.seppur.2023.123875
Thesis / Dissertation
  1. "Human fluids pretreatment using three-phase partitioning systems for the diagnosis and prognosis of lung cancer". Master, Universidade de Aveiro, 2021. http://hdl.handle.net/10773/31941.
  2. "Novos sistemas de administração controlada de fármacos anti-inflamatórios não-esteróides". Degree, Universidade de Aveiro, 2019.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/10/30 Detection of cancer biomarkers using microfluidic devices assisted by serum pretreatment with ionic liquid-based aqueous biphasic systems 43rd International Symposium and Exhibit on the Separation, Purification and Characterization of Biologically Important Molecules
(Delray Beach, United States)
2024/07/17 Enhanced cancer biomarker detection in microfluidic devices using ionic liquid-based aqueous biphasic systems for serum pretreatment 16th National Physical Chemistry Meeting (16ENQF) and 5th Computational Chemistry Symposium
Faculdade de Ciências da Universidade de Lisboa (Lisboa, Portugal)
2024/05/17 Ionic-liquid-based aqueous biphasic systems: An efficient platform for breast cancer biomarker extraction 6th Meeting of Medicinal Biotechnology
Escola Superior de Saúde do Porto (Porto, Portugal)
2023/09/22 Enhancing sample pretreatment and biomarker extraction using ionic liquid-based aqueous biphasic systems Path Workshop
Universidade de Aveiro (Aveiro, Portugal)
2023/07/12 Ionic liquid-based aqueous biphasic systems as effective platforms for human serum pretreatment and breast cancer biomarkers extraction Research Summit
Universidade de Aveiro (Aveiro, Portugal)
2023/02/08 Improved sample pretreatment and biomarker extraction using aqueous biphasic systems comprising ionic liquids ILSEPT - 5th International Conference on Ionic Liquids in Separation and Purification Technology
Elsevier (Scotsdalle, Arizona, United States)
2023/02/06 Extraction of breast cancer biomarkers from human serum using ionic liquid-based aqueous biphasic systems ILSEPT - 5th International Conference on Ionic Liquids in Separation and Purification Technology
Elsevier (Scotsdalle, Arizona, United States)
2022/06 Enhancing human serum pretreatment using ionic liquids as adjuvants in polymer-salt-based tree-phase partitioning systems Euchemsil2022
(Patras, Greece)
2021/11/22 Pretreatment of biological samples using three-phase partitioning systems: a tool to enhance early diagnosis Microbiotec 21 - Congress of Microbiology and Biotechnology 2021
(Lisboa, Portugal)
2021/11/07 Aqueous biphasic systems comprising homo- or copolymers and a citrate buffered salt: Ternary liquid-liquid phase equilibria 19th Internation Symposium on Solubility on Solubility Phenomena and Related Equilibrium Processes (ISSP-19)
2021/10/06 Improved detection of lung cancer biomarkers using three-phase partitioning systems as human serum pretreatment techniques Jornadas CICECO 2021
CICECO (Aveiro, Portugal)
2021/06/17 Delivery of Deep Eutectic Solvents Comprising Nonsteroidal Anti-inflammatory Drugs using Biopolymer Based Systems 2nd International Meeting on Deep Eutectic Systems
(Lisboa, Portugal)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2024/10/10 - Current Attendance to Jornadas do CICECO 2024 with poster communication
Conference
Jornadas do CICECO 2024
Universidade de Aveiro CICECO, Portugal
2023/09/22 - Current Attendance to Path Workshop - Universidade de Aveiro with oral communication
Workshop
Path Workshop
Universidade de Aveiro, Portugal
2023/07/12 - Current Attendance to Research Summit - Universidade de Aveiro with oral communication
Conference
Research Summit
2024/11/20 - 2024/11/22 Attendance to 7th Iberoamerican Meeting on Ionic Liquids with poster presentation
Conference
7th Iberoamerican Meeting on Ionic Liquids
Universidade de Coimbra, Portugal
2024/10/27 - 2024/10/30 Attendance to 43rd International Symposium and Exhibit on the Separation, Purification and Characterization of Biologically Important Molecules with oral communication
Conference
43rd International Symposium and Exhibit on the Separation, Purification and Characterization of Biologically Important Molecules
2024/07/17 - 2024/07/19 Attendance to 16th National Physical Chemistry Meeting (16ENQF) and 5th Computational Chemistry Symposium with oral communication
Conference
16th National Physical Chemistry Meeting (16ENQF) and 5th Computational Chemistry Symposium
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2024/05/17 - 2024/05/17 Attendance to 6th Meeting of Medicinal Biotechnology with oral communication
Conference
6th Meeting of Medicinal Biotechnology
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2023/12/07 - 2023/12/09 Attendance to Microbiotec 2023 - Congress of Microbiology and Biotechnology Conference with poster communication
Conference
Microbiotec 2023 - Congress of Microbiology and Biotechnology Conference
Universidade da Beira Interior, Portugal
2023/09/12 - 2023/09/15 Attendance to CHEMPOR - 14th International Chemical and Biological Engineering Conference with poster communication
Conference
14th International Chemical and Biological Engineering Conference
Instituto Politécnico de Bragança, Portugal
2023/07/05 - 2023/07/07 Attendance to Ciência 2023 with poster communication.
Conference
Ciência 2023
2023/02/05 - 2023/02/08 Attendance to ILSEPT - 5th International Conference on Ionic Liquids in Separation and Purification Technology with oral communication.
Conference
ILSEPT - 5th International Conference on Ionic Liquids in Separation and Purification Technology
Elsevier Inc, United States
2022/10/21 - 2022/10/21 Attendance to 5EBTM - Encontro de Biotecnologia Medicinal with poster presentation
Congress
5 EBTM - Encontro de Biotecnologia Medicinal
2022/10/12 - 2022/10/12 Attendance to Jornadas CICECO 2022 with poster presentation.
Meeting
Jornadas do CICECO 2022
Universidade de Aveiro, Portugal
2022/09/25 - 2022/09/28 Attendance to Biopartitioning & Purification Conference with poster presentation
Conference
Biopartitioning & Purification Conference
2022/04/06 - 2022/04/06 Attendance to 10th Workshop in Lipidomics - Health & Disease.
Workshop
Universidade de Aveiro, Portugal
2022/03/14 - 2022/03/16 Attendance to 2nd European Sample Preparation e-Conference (EuSP2022) with poster presentation.
Conference
2nd European Sample Preparation e-Conference (EuSP2022)
2021/11/23 - 2021/11/26 Attendance to Microbiotec 21-Congress of Microbiology and Biotechnology 2021 with oral communication.
Congress
Microbiotec 21-Congress of Microbiology and Biotechnology 2021
Universidade Nova de Lisboa, Portugal
2021/11/07 - 2021/11/10 Attendance to 40th International Symposium on the Separation of Proteins, Peptides & Polynucleotides with poster presentation.
Symposium
40th International Symposium on the Separation of Proteins, Peptides & Polynucleotides
2021/10/06 - 2021/10/07 Attendance to Jornadas CICECO 2021 with poster presentation and oral communication.
Meeting
Jornadas CICECO 2021
Universidade de Aveiro, Portugal
2021/07/11 - 2021/07/16 Attendance to 19th International Symposium on Solubility Phenomena and Related Equilibrium Processes with oral communication.
Symposium
19th International Symposium on Solubility Phenomena and Related Equilibrium Processes
2021/07/08 - 2021/07/15 Participation in the Born from Knowledge (BfK) ideas 2020 with the project: CTRL ALT IMMUN: Controlling population immunity to coronavirus at the point of impact.
Other
Born from Knowledge (BfK) ideas 2020
Agência Nacional de Inovação SA, Portugal
2019/05/15 - 2019/05/15 Attendance to XI Biochemistry Day - The challenges and opportunities of Biochemistry organized by the Students' Nucleus of the Department of Chemistry of the University of Aveiro.
Conference
XI Biochemistry Day -The challenges and opportunities of Biochemistry
Universidade de Aveiro, Portugal
2019/04/12 - 2019/04/15 Attendance to XII National Meeting of Biochemistry students.
Meeting
XII Nacional gathering of Biochemistry students
Universidade de Aveiro, Portugal
2019/04 - 2019/04 Attendance to the Workshop Entrepreneurship and Start-up at University of Aveiro.
Workshop
Entrepreneurship and Start-up
Universidade de Aveiro, Portugal
2019/04 - 2019/04 Attendance to the Workshop Magnetism around us (and inside us) at University of Aveiro.
Workshop
Magnetism around us (and inside us)
Universidade de Aveiro, Portugal
2019/02/26 - 2019/03/13 Attendance to the Workshop Python for data science at University of Aveiro. The course included three sessions of 3 hours each.
Workshop
Python for data science
Universidade de Aveiro, Portugal

Mentoring / Tutoring

Topic Student name
2023/10/01 - 2024/10/31 Application of aqueous biphasic systems in the pretreatment of human serum and bisphenol A extraction Inês Bruno Santana
2024/03/01 - 2024/07/20 Líquidos iónicos suportados no pré-tratamento de urina para fins de diagnóstico Maria Inês Zilhão de Sá Caçoilo
2024/03/01 - 2024/07/20 Pretreatment of human fluids using alternative adsorbents for diagnostic purposes Hugo Miguel Dias dos Santos
2022/10/01 - 2023/10/01 Pré-tratamento de soro usando sistemas aquosos bifásicos e extração em fase sólida para deteção do cancro da próstata Sofia Ferreira Pedro
2022/03/10 - 2022/06/24 Uso de sistemas aquosos bifásicos no pré-tratamento de soro humano para quantificação de biomarcadores do cancro da próstata Eduarda Fernandes do Carmo
2022/03/10 - 2022/06/24 Uso de sistemas aquosos bifásicos no pré-tratamento de soro humano para quantificação de biomarcadores do cancro da mama Maria Clara Dutra de Souza
Distinctions

Award

2024 Best poster award
2023 2nd Place Best Oral Communication
Elsevier Inc, United States
2022 Best Poster Award
Universidade de Aveiro, Portugal