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Ildete L Ferreira is currently an Assistant Investigator at the CNC-Center for Neuroscience and Cell Biology, University of Coimbra (UC), integrated in Mitochondria and Neurodegenerative Disorders (MiND) group headed by A. Cristina Rego. She works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine, particularly Neurosciences. She graduated in Biochemistry in 1987 from UC, and completed her Master degree in Cellular Biology in 1993 and her PhD degree in Cell Biology also from UC under the supervision of Prof. Arsélio Pato de Carvalho. As a postdoc, she moved to the Department of Cell Biology, University of Aveiro and in 2005, she returned to the CNC to joint A. Cristina Rego lab. In 2008 she awarded a position as "Ciência Investigator". Currently, she is Principal Investigator in a funded FCT project, having been a team member of 18 additional research projects. Her main contribution has been focused on studying mitochondrial dysfunction, biogenesis and dynamics and cell signaling processes, including redox dysregulation and related glutamatergic dysfunction in Alzheimer's (AD) and Huntington¿s (HD) disorders to understand the cellular mechanisms that occur in early phases of the disease. Currently, she is interested in studying the role of transcription deregulation by targeting class I and II histone deacetylases as therapeutic strategy to treat mitochondrial dysfunction in Alzheimer¿s disease. In addition, she is motivated to study dysfunction of cortico-striatal glutamatergic synapses through the analysis of striatal dendritic SAPAP3 and related proteins in early psychiatric disturbances in pre-motor stages of Huntington's disease. To date her work has accrued >2180 citations and as led to primary research papers in peer-reviewed journals as described in 42 PubMed indexed publications (35 original/7 reviews) and 4 book chapters and an h index of 27 an i10 index of 36 and an accumulated impact factor of 150,86. IL Ferreira is also author of more than 140 abstracts in research meetings (39 oral communications and 101 posters in conferences) and was awarded in 4 poster/2 oral communication. She has co-supervised 2 PhD students (one concluded and one ongoing), 20 Master students, 3 undergraduate students and 13 lab rotations. She also acts as ad-hoc reviewer for scientific peer-reviewed journals.
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Identification

Personal identification

Full name
Ildete Luísa de Araújo Ferreira

Citation names

  • Ferreira, IL

Author identifiers

Ciência ID
691B-D9E3-6368
ORCID iD
0000-0001-6552-4479
Google Scholar ID
http://scholar.google.pt/citations?hl=pt-PT&user=ocpw3_MAAAAJ&view_op=list_works
Scopus Author Id
7102134994

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Portuguese (Mother tongue)
Education
Degree Classification
2003
Concluded
 PhD in Cellular Biology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Toxicidade em células amácrinas da retina em cultura-envolvimento dos receptores ionotrópicos do glutamato em ambientes excitotóxicos" (THESIS/DISSERTATION)
 Very Good with Distinction and Honour
1993
Concluded
 Master in Cellular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Regulação da libertação de [3H]GABA por receptores do glutamato em células da retina em cultura" (THESIS/DISSERTATION)
 Very Good
1987
Concluded
 Bachelor in Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Purificação e caracterização química da glicoproteína P-80 em substância branca e do cérebro e plasma humanos" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2018/07 - Current Contracted Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/10 - 2018/06 Postdoc (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/05 - 2015/09 Research Assistant (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01 - 2009/04 Postdoc (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2003/10 - 2004/09 Postdoc (Research) Universidade de Aveiro, Portugal
2002/01 - 2003/09 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1993/12 - 1998/12 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1987/01 - 1992/12 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Grant

Designation Funders
2018 - 2022 Transcriptional activity modulation in Alzheimer's disease by inhibitors of histone deacetylases
POCI-01-0145-FEDER-032316
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019 - 2020 Análise da (dis)função mitocondrial e alterações redox em células sanguíneas derivadas de doentes com Diabetes mellitus tipo-2 e periodontite
Programa de Estímulo a Projetos de Investigação Interdisciplinar e Translacional (PEPITA)
Researcher
Universidade de Coimbra Faculdade de Medicina, Portugal
 Banco Santander Portugal
Concluded
2018 - 2019 Exploring striatal postsynaptic SAPAP3 in Huntington's disease
European Huntington Disease Network (EHDN)
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Euro-HD Network, EHDN
2014 - 2016 Evaluation of oxidative stress and mitochondrial dysfunction in animal models and patients of Huntington's disease using Cu(II)-ATSM PET
Prémio Neurociências Mantero Belard 2013 (1ª edição)
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Santa Casa da Misericórdia de Lisboa
Concluded
2013 - 2015 New strategies to manage brain diseases
CENTRO-07-ST24-FEDER-002002
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 QREN ‘Mais Centro’
Concluded
2010 - 2013 Analysis of transcription deregulation in brain and peripheral Huntington's disease models: influence of modulating histone deacetylases
PTDC/SAU-FCF/108056/2008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
2009 - 2011 Phosphorylation and oxidation of NMDA receptor subunits in Alzheimer's disease and protective role of memantine
Lundbeck 2009-2011
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 H Lundbeck AB
2007 - 2010 Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer's disease
PTDC/SAU-NEU/71675/2006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
2006 - 2010 Aging, Stress And Chronic Diseases: From Mechanisms to Therapeutics
CENTRO-07-ST24-FEDER-002006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 QREN ‘Mais Centro’
2005 - 2008 Transcription regulation by FK506 and BDNF control mitochondrial-dependent cell death: a protective role in Huntington's disease
POCTI/SAU-NEU/57310/2004
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
2005 - 2006 Oxidative stress in Huntington's disease cybrids and striatal cells expressing mutant huntingtin
III/BIO/49/2005
Post-doc
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra Instituto de Investigação Interdisciplinar
2003 - 2004 Molecular basis of Alzheimer's disease
QLK-CT-2001-02 362
Researcher
Universidade de Aveiro, Portugal
 DIADEM
2003 - 2004 Stress and AD: A molecular approach
(POCTI/NSE/33520/2000)
Researcher
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
2002 - 2003 Influence of sexual hormones on the production of inflammatory mediators and on condrocyte metabolism
POCTI 43638/99
Researcher
Fundação para a Ciência e a Tecnologia
1994 - 1999 Spatial distribution of glutamate receptors and of calcium channels as determined by imaging techniques
PRAXIS/2/2.1/BIA/74/94; PRAXIS XXI; 09/1996-09/1999
Researcher
Fundação para a Ciência e a Tecnologia
1995 - 1998 Activity of the glutamate receptors in cholinergic amacrine cells; imagiology studies
PBIC/BIA/2079/95
Researcher
Fundação para a Ciência e a Tecnologia
1993 - 1997 Toxicidade em células amácrinas da retina em culturaenvolvimento dos receptores ionotrópicos do glutamato em ambientes excitotóxicos
CIÊNCIA/BD/2564/93
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
1991 - 1994 Calcium metabolism and neurosecretion
----
Researcher
Fundação para a Ciência e a Tecnologia
1990 - 1991 Regulation of the intracellular pH
----
Researcher

Other

Designation Funders
2013 - 2014 Strategic Project - LA 1 - 2013-2014
PEst-C/SAU/LA0001/2013
Researcher
Fundação para a Ciência e a Tecnologia
2011 - 2012 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Researcher
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Marinho, D; Lorenzoni, R; Ferreira, IL; Rego, AC. "Communication between mitochondria and other organelles: ER-mitochondria crosstalk". In Mitochondria in Neurological Disorders. Elsevier, 2022.
    In press
  2. Ferreira, IL; Carmo, C; Naia, L; Mota, SI; Rego, AC. "Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington's Disease". In Methods in Molecular Biology, 415-442. Springer, 2018.
    Published • 10.1007/978-1-4939-7825-0_19
  3. Ferreira, IL; Duarte, EP; Comprido, D; Baltazar, G; Rego, AC; Duarte, CB. "Fatores neurotróficos - principais recetores e vias de sinalização". In Neurociências, 231-252. Portugal: Lidel, 2017.
    Published
  4. Cunha-Oliveira, T; Ferreira, IL; Rego, AC. "Consequences of Mitochondrial Dysfunction in Huntington's Disease and Protection via Phosphorylation Pathways". In Huntington's Disease - Core Concepts and Current Advances, 361-390. InTech, 2012.
    Published • 10.5772/32728
Conference abstract
  1. Moraes, BJ; Ferreira, IL; Lino, P; Passos, D; Coelho, P; Fão, L; Peça, J; Rego, AC. "Postsynaptic decrease of SAPAP3 scaffold protein in Huntington's disease". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisboa, 2019.
    Published
  2. Rego, AC; Ferreira, IL; Ferreiro, E; Cardoso, JM; Oliveira, CR. "NMDA receptors mediate calcium rise and mitochondrial dysfunction caused by amyloid-beta peptide in cortical neurons". Paper presented in 2012 Neuroscience Meeting Planner, Online, 2012.
    Published
  3. Cunha-Oliveira, T; Naia, L; Ferreira, IL; Rosenstock, TR; Duarte, AI; Ribeiro, M; Laço, MN; et al. "Activation of IGF-1 and insulin signaling pathways ameliorate energy metabolism and mitochondrial function in Huntington’s disease human lymphoblasts". Paper presented in 2012 Neuroscience Meeting Planner, Online, 2012.
    Published
  4. Ferreiro, E; Ferreira, IL; Cardoso, JM; Oliveira, CR; Pereira, CM; Rego, AC. "Amyloid-beta 1-42 peptide-evoked changes in calcium levels and mitochondrial function through activation of NMDA receptors in rat cortical neurons". Paper presented in FENS2012, Barcelona, 2012.
    Published
  5. Ferreira, IL; Mota, SI; Bajouco, LM; d'Amati, C; Oliveira, CR; Rego, AC. "Involvement of GluN2B subunit in amyloid-beta peptide-induced calcium rise and ROS in rat cortical neurons". Paper presented in FENS2012, Barcelona, 2012.
    Published
  6. Mota, SI; Ferreira, IL; Ferreiro, E; Pereira, CM; Oliveira, CR; Rego, AC. "Age and gender-dependent modifications in NMDA receptor subunits in the cortex and hippocampus of Alzheimer's disease transgenic mice". Paper presented in FENS2012, Barcelona, 2012.
    Published
  7. Mota, SI; Ferreira, IL; Pereira, CM; Oliveira, CR; Rego, AC. "Amyloid-beta oligomers cause microtubule deregulation through NMDA receptors in mature hippocampal neurons". Paper presented in 10th AD/PD 2011 Conference, Barcelona, 2011.
    Published
  8. Ferreira, IL; Mota, SI; Costa, RO; Padovano, C; Fonseca, AC; Letra, L; Oliveira, CR; et al. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Paper presented in 10th AD/PD 2011 Conference, Barcelona, 2011.
    Published
  9. Ferreiro, E; Ferreira, IL; Cardoso, JM; Oliveira, CR; Pereira, CM; Rego, AC. "Mitochondria control NMDA receptor-dependent calcium rise evoked by amyloid-ß 1-42 oligomers in rat cortical neurons". Paper presented in Alzheimer's Association International Conference (AAIC) 2011, Paris, 2011.
    Published
  10. Cunha-Oliveira, T; Ferreira, IL; Nascimento, MV; Ribeiro, M; Proença, MT; Januário, C; Oliveira, CR; Rego, AC. "Impairment of energy metabolism in Huntington's disease human cybrids". Paper presented in 2011 Neuroscience Meeting Planner, Online, 2011.
    Published
  11. Ribeiro, M; Rosenstock, TR; Ferreira, IL; Oliveira, CR; Rego, AC. "Modulation of antioxidant-related proteins by insulin and IGF-1 in Huntington’s disease knock-in striatal cells". Paper presented in 2010 Neuroscience Meeting Planner, Online, 2010.
    Published
  12. Rego, AC; Ferreira, IL; Mota, SI; Bajouco, LM; Pereira, CM; Oliveira, CR. "Early intracellular calcium deregulation and microtubule disassembly induced by amyloid-beta 1-42 oligomers in primary cultured neurons – role of NR2B receptor subunit". Paper presented in FENS2010, Amsterdam, 2010.
    Published
  13. Oliveira, CR; Ferreira, IL; Costa, RO; Mota, SI; Bajouco, LM; Lacor, PN; Clyne, WL; Rego, AC; Pereira, CM. "Binding of amyloid-beta oligomers to NR2B subunits is associated with endoplasmic reticulum stress in hippocampal neurons". Paper presented in 2009 Neuroscience Meeting Planner, Online, 2009.
    Published
  14. Ferreira, IL; Mota, SI; Bajouco, LM; Pereira, CM; Oliveira, CR; Rego, AC. "Role of NMDA Receptors Subunits NR2A and NR2B on Neuronal Dysfunction caused by Oligomeric Amyloid-beta Peptide". Paper presented in XI Meeting of the Portuguese Society for Neuroscience (SPN2009), Braga, 2009.
    Published
  15. Ferreira, IL; Nascimento, MV; Ribeiro, M; Almeida, S; Cardoso, SM; Januário, C; Oliveira, CR; Rego, AC. "Apoptotic Cell Death and Oxidative Stress in Huntington". Paper presented in XI Meeting of the Portuguese Society for Neuroscience (SPN2009), Braga, 2009.
    Published
  16. Ferreira, IL; Ribeiro, M; Nascimento, MV; Almeida, S; Louros, S; Cardoso, SM; Januário, C; Oliveira, CR; Rego, AC. "Increased susceptibility to apoptosis and oxidative stress in Huntington’s disease cybrids". Paper presented in 5th Plenary Meeting of the European Huntington's Disease Network (EHDN), Lisboa, 2008.
    Published
  17. Ribeiro, M; Ferreira, IL; Duarte, AI; Oliveira, CR; Rego, AC. "Detailing oxidative stress features in an in vitro model of Huntington’s disease". Paper presented in 5th Plenary Meeting of the European Huntington's Disease Network (EHDN), Lisboa, 2008.
    Published
  18. Duarte, AI; Ribeiro, M.; Ferreira, IL; Oliveira, CR; Rego, AC. "Insulin protects from oxidative stress and caspase-3 activation in an in vitro model of Huntington’s disease". Paper presented in 5th Plenary Meeting of the European Huntington's Disease Network (EHDN), Lisboa, 2008.
    Published
  19. Ribeiro, M; Nascimento, MV; Louros, S; Ferreira, IL; Almeida, S; Cardoso, SM; Oliveira, CR; Rego, AC. "Oxidative stress in striatal cells expressing mutant huntingtin and in Huntington's disease cybrids". Paper presented in Society for Free Radical Research (SFRR)-Europe Meeting 2007, Vilamoura, 2007.
    Published
  20. Carvalho, AP; Santos, PF; Ferreira, IL; Duarte, CB. "Release of glutamate by chick retina cells in culture: Role of Ca2+ and arachidonic acid". Paper presented in Association for Research in Vision and Ophthalmology 1996 annual meeting, Fort Lauderdale, FL, 1996.
    Published
  21. Ferreira, IL; Santos, PF; Duarte, CB; Carvalho, AP. "Glutamate increases the [Ca2+]i but stimulates Ca2+-independent release of 3H-GABA in cultured chick retina cells". 1993.
    Published • 10.1016/0197-0186(92)91968-3
  22. Ferreira, IL; Santos, PF; Carvalho, AP. "Excitatory amino-acid regulation on [3H]GABA release from cultured chick retina cells". Paper presented in 14th International Society for Neurochemistry (ISN) Meeting, Montpelljer, 1993.
    Published
  23. Carvalho, CM; Duarte, CB; Ferreira, IL; Carvalho, AP. "Relation of [3H]GABA and membrane potential to dopamine release in striatum synaptosomes". Paper presented in 14th International Society for Neurochemistry (ISN) Meeting, Montpelljer, 1993.
    Published
Conference poster
  1. Lorenzoni, R; Marinho, D; Ferreira, IL; Rego, AC. "Transcriptional modulation of mitochondrial function by histone deacetylase inhibitors in cell models of Alzheimer’s disease". Paper presented in XVII Meeting of the Portuguese Society for Neurosciences (SPN2021), 2021.
  2. Marinho, D; Ferreira, IL; Rego, AC. "Nuclear histone deacetylases control ER-mitochondria crosstalk in Alzheimer’s disease cell model". Paper presented in XVII Meeting of the Portuguese Society for Neurosciences (SPN2021), 2021.
  3. Coelho, P; Lourenço, AS; Ferreira, IL; Marinho, D; Anjo, SI; Mas, P; Carvalho, M; et al. "Postsynaptic SAPAP3 modulates mitochondrial function and dynamics". Paper presented in XVII Meeting of the Portuguese Society for Neurosciences (SPN2021), 2021.
  4. Muñoz-Montero, A; Marinho, D; Ferreira, IL; Gandía, L; Rego, AC. "Calcium signaling involving P2x7 receptor activation in astrocytes of APP/PS1 Alzheimer's Disease mice". Paper presented in V Symposium of the Portuguese Glial Network: Glial cells at the crossroad of health and disease, 2021.
  5. Esteves, AR; Munoz-Pinto, MF; Candeias, E; Silva, DF; Magalhães, JD; Ferreira, IL; Pereira-Santos, AR; et al. "The Parkinson Pandemic: a microbial toxin elicits Parkinson’s disease-like neurodegeneration". Paper presented in 55th Annual Scientific Meeting of the ESCI-European Society for Clinical Investigation, 2021.
  6. Rego, AC; Marinho, D; Ferreira, IL. "Histone deacetylase inhibitors alleviate mitochondrial and ER-calcium retention in cell models of Alzheimer’s disease". Paper presented in 12th FENS Forum of Neuroscience, 2020.
  7. Ferreira, IL; Marinho, D; Rego, AC. "Modified mitochondrial function by histone deacetylase inhibitors in neuronal models of Alzheimer’s disease". Paper presented in 49th Annual Meeting of the Society for Neuroscience (SFN), 2019.
  8. Fokt, O; Ferreira, IL; Costa, AS; Baptista, IP; Rego, AC. "Atividade mitocondrial e antioxidante em doentes com diabetes mellitus e periodontite". Paper presented in XXXIX Anual Meeting Sociedade Portuguesa de Estomatologia e Medicina Dentária (SPEMD), 2019.
  9. Marinho, D; Ferreira, IL; Rego, AC. "Histone deacetylase inhibitors prevent mitochondrial calcium retention in hippocampal neurons from a mice model of Alzheimer's disease". Paper presented in 8th Workshop of the European Calcium Society (ECS): “Cell Signaling in Aging and Neurodegenerative Diseases”, 2019.
  10. Marinho, D; Ferreira, IL; Rego, AC. "Modified mitochondrial function by class I histone deacetylase inhibitors in cell models of Alzheimer’s disease". Paper presented in Ageing: models, mechanisms and therapies, 2019.
  11. Marinho, D; Martinho, V; Duarte, AI; Ferreira, IL; Rego, AC. "Role of class I histone deacetylase inhibitors in cell and animal models of Alzheimer’s disease". Paper presented in XVI Meeting of the Portuguese Society for Neurosciences (SPN2019), 2019.
  12. Moraes, BJ; Ferreira, IL; Lino, P; Passos, D; Coelho, P; Fão, L; Rego, AC. "Postsynaptic decrease of SAPAP3 scaffold protein in Huntington’s disease". Paper presented in XVI Meeting of the Portuguese Society for Neurosciences (SPN2019), 2019.
  13. Candeias, E; Esteves, AR; Magalhães, JD; Silva, DF; Ferreira, IL; Rego, AC; Empadinhas, N; Cardoso, SM. "Pathogen-associated molecular patterns as culprits for mitochondria-driven Parkinson disease neurodegeneration (P170-T)". Paper presented in 53rd Annual Scientific Meeting of the ESCI-European Society for Clinical Investigation, 2019.
  14. Esteves, AR; Candeias, E; Silva, DF; Magalhães, JD; Ferreira, IL; Rego, AC; Empadinhas, N; Cardoso, SM. "Mitochondria as a probable target of a bacterial neurotoxin: relevance to Parkinson’s disease etiology". Paper presented in 14th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD Meeting), 2019.
  15. Silva, DF; Candeias, E; Esteves, AR; Magalhães, JD; Ferreira, IL; Rego, AC; Empadinhas, N; Cardoso, SM. "Cortical neurons exposed to bacteria metabolites develop Alzheimer's disease-related hallmarks". Paper presented in 14th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD Meeting), 2019.
  16. Candeias, E; Esteves, AR; Magalhães, JD; Ferreira, IL; Rego, AC; Empadinhas, N; Cardoso, SM. "Chronic antibiotic treatment induces neurodegenerative features through the mitochondria". Paper presented in 14th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD Meeting), 2019.
  17. Baptista, IP; Costa, AS; Ferreira, IL; Rego, AC. "Resistin levels and its relation with body mass index and hydrogen peroxide production in blood cells from diabetic periontal patients". Paper presented in 9th Congress of European Federation of Periodontology, 2018.
  18. Costa, AS; Ferreira, IL; Rego, AC; Baptista, IP. "Níveis de resistina e de peróxido de hidrogénio em doentes com diabetes e periodontite". Paper presented in XXXVII Anual Meeting Sociedade Portuguesa de Estomatologia e Medicina Dentária (SPEMD), 2017.
  19. Lino, P; Ferreira, IL; Hayden, M; Peça, J; Rego, AC. "SAPAP3 levels in post synaptic densities in Huntington’s disease". Paper presented in 8th Meeting on Signal Transduction (SINAL), 2017.
  20. Maranga, C; Ferreira, IL; Mota, SI; Laço, MN; de Rosa, M; Sereno, J; Oliveira, FP; et al. "Major mitochondrial modifications in striatum and cortex of early symptomatic Huntington’s disease mouse model". Paper presented in MitoPorto - Advances in Mitochondrial Research International Symposium, 2017.
  21. Almeida, F; Ferreira, IL; Naia, L; Lopes, C; Duarte-Silva, S; Maciel, P; Rego, AC. "Mutant ataxin-3 causes mitochondrial dysfunction in PC6-3 cells and in the cerebellum of Machado-Joseph disease transgenic mouse model". Paper presented in MitoPorto - Advances in Mitochondrial Research International Symposium, 2017.
  22. Costa, AS; Ferreira, IL; Rego, AC; Baptista, IP. "Análise dos níveis de resistina em doentes diabéticos com periodontite". Paper presented in XXVI Reunião Anual de Medicina Dentária e Estomatologia de Coimbra (RAMDEC), 2017.
  23. Ferreira, IL; Maranga, C; Mota, SI; Laço, MN; Sereno, J; Abrunhosa, A; Hayden, M; Castelo-Branco, M; Rego, AC. "Redox and mitochondrial functional switches in striatum and cortex of pre-symptomatic and symptomatic Huntington’s disease mouse model". Paper presented in XIX National Congress of Biochemistry (SPB), 2016.
  24. Rego, AC; Maranga, C; Ferreira, IL; Laço, MN; Mota, SI; Naia, L; Sereno, J; et al. "Redox changes and bioenergetic defects in striatum and cortex of pre-symptomatic andsymptomatic Huntington disease mice". Paper presented in 46th Annual Meeting of the Society for Neuroscience (SFN), 2016.
  25. Almeida, F; Naia, L; Ferreira, IL; Duarte-Silva, S; Maciel, P; Rego, AC. "Machado-Joseph disease models exhibit impaired mitochondrial function". Paper presented in XL Jornadas Portuguesas de Genética, 2016.
  26. Mota, SI; Laço, MN; de Rosa, M; Maranga, C; Ferreira, IL; Rego, AC. "Age-dependent oxidative stress in presynaptic terminals of a mouse model of Huntington’s disease". Paper presented in 7th Regional Meeting of the International Society for Neurochemistry (ISN), 2016.
  27. Maranga, C; de Rosa, M; Laço, MN; Mota, SI; Ferreira, IL; Rego, AC. "Altered oxidative stress-related proteins in Huntington’s disease YAC128 mouse model". Paper presented in XIII Encontro Anual do Centro de Neurociências e Biologia Celular, 2015.
  28. Laço, MN; Mota, SI; Ferreira, IL; Rego, AC. "Huntington’s disease YAC128 transgenic mouse model exhibits increased brain levels of hydrogen peroxide". Paper presented in XIV Meeting of the Portuguese Society for Neurosciences, 2015.
  29. Ferreiro, E; Lanzillo, M; Carvalho da Silva, AM; Mastrella, G; Mota, SI; Fontes, AR; Ferreira, IL; et al. "Linking impairment of hippocampal neurogenesis and memory loss in a diabetic-like Alzheimer’s disease mouse model". Paper presented in Adult Neurogenesis: Evolution, Regulation and Function, 2015.
  30. Laço, MN; Mota, SI; Ferreira, IL; Rego, AC. "Hydrogen peroxide production increases with Huntington’s disease progression in brains of YAC128 transgenic animal model". Paper presented in XVIII National Congress of Biochemistry (SPB), 2014.
  31. Ferreira, IL; Ferreiro, E; Schmidt, J; Cardoso, JM; Pereira, CMF; Carvalho, AL; Oliveira, CR; Rego, AC. "Amyloid-beta peptide and N-methyl-D-aspartate receptor activation cause mitochondrial dysfunction involving calcium release from endoplasmic reticulum". Paper presented in XVIII National Congress of Biochemistry (SPB), 2014.
  32. Ferreiro, E; Lanzillo, M; Silva, A; Mastrella, G; Fontes, AR; Ferreira, IL; Oliveira, CR; Valero, J; Rego, AC. "Impaired memory in a transgenic mouse model of Alzheimer’s disease under hyperglycemia – a link to reduced hippocampal neurogenesis?". Paper presented in XIII Encontro Anual do Centro de Neurociências e Biologia Celular, 2014.
  33. Mota, SI; Ferreira, IL; Valero, J; Ferreiro, E; Carvalho, AL; Oliveira, CR; Rego, AC. "Impaired Src signaling and post-synaptic actin polymerization in Alzheimer´s disease mice hippocampus - linking NMDA receptors and the reelin pathway". Paper presented in XIII Encontro Anual do Centro de Neurociências e Biologia Celular, 2014.
  34. Ferreira, IL; Ferreiro, E; Schmidt, J; Cardoso, JM; Pereira, CMF; Carvalho, AL; Oliveira, CR; Rego, AC. "Synergistic effect of Aß and GluN2B-composed NMDA receptor activation on mitochondrial dysregulation involving calcium release". Paper presented in XIII Encontro Anual do Centro de Neurociências e Biologia Celular, 2014.
  35. Ferreira, IL; de Rosa, M; Caldeira, G; Oliveira, CR; Rego, AC. "Early changes in Ca2+-dependent CREB and ERK activity induced by oligomers of beta-amyloid 1-42 involve the activation of NMDA receptors". Paper presented in 4th PF2MUC Symposium Personalized Medicine: Myth or Reality? Dia da Faculdade de Medicina, 2013.
  36. Mota, SI; Ferreira, IL; Ferreiro, E; Valero, J; Carvalho, AL; Oliveira, CR; Rego, AC. "Altered NMDA receptor and Src related signaling in Alzheimer’s disease". Paper presented in 4th PF2MUC Symposium Personalized Medicine: Myth or Reality? Dia da Faculdade de Medicina, 2013.
  37. Regateiro, FJ; Carvalho CAM; Ferreira IL; Cragoe Jr. EJ; Carvalho AP. "Na+/Ca2+ exchange and free cytoplasmic Ca2+ changes in HL-60 cells before and after induced differentiation by retinoic acid". Paper presented in 19th FEBS Meeting, 1989.
Journal article
  1. Almeida, Filipa; Ferreira, Ildete L.; Naia, Luana; Marinho, Daniela; Vilaça-Ferreira, Ana Catarina; Costa, Marta D.; Duarte-Silva, Sara; Maciel, Patrícia; Rego, A. Cristina. "Mitochondrial Dysfunction and Decreased Cytochrome c in Cell and Animal Models of Machado–Joseph Disease". Cells 12 19 (2023): 2397. http://dx.doi.org/10.3390/cells12192397.
    10.3390/cells12192397
  2. Marinho, Daniela; Ferreira, Ildete Luísa; Lorenzoni, Ricardo; Cardoso, Sandra M.; Santana, Isabel; Rego, A. Cristina. "Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease". Aging Cell 22 8 (2023): http://dx.doi.org/10.1111/acel.13895.
    10.1111/acel.13895
  3. Ferreira, Ildete L.; Costa, Solange; Moraes, Bruno J.; Costa, Ana; Fokt, Olga; Marinho, Daniela; Alves, Vera; Baptista, Isabel P.; Rego, A. Cristina. "Mitochondrial and Redox Changes in Periodontitis and Type 2 Diabetes Human Blood Mononuclear Cells". Antioxidants 12 2 (2023): 226. http://dx.doi.org/10.3390/antiox12020226.
    10.3390/antiox12020226
  4. Carvalho da Silva, AM; Lemos, C; Silva, HB; Ferreira, IL; Tomé, AR; Rego, AC; Cunha, RA. "Simultaneous alteration of the circadian variation of memory, hippocampal synaptic plasticity and metabolism in a triple transgenic mouse model of Alzheimer's disease". Frontiers in Aging Neuroscience (2022):
    In press
  5. Esteves, AR; Munoz-Pinto, MF; Nunes-Costa, D; Candeias, E; Silva, DF; Magalhães, JD; Pereira-Santos, AR; et al. "Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria". Gut (2021): http://dx.doi.org/10.1136/gutjnl-2021-326023.
    10.1136/gutjnl-2021-326023
  6. Toledo, JP; Fernández-Pérez, EJ; Ferreira, IL; Marinho, D; Riffo-Lepe, NO; Pineda-Cuevas, BN; Pinochet-Pino, LF; et al. "Boldine Attenuates Synaptic Failure and Mitochondrial Deregulation in Cellular Models of Alzheimer's Disease". Frontiers in Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnins.2021.617821.
    10.3389/fnins.2021.617821
  7. Moraes, BJ; Coelho, P; Fão, L; Ferreira, IL; Rego, AC. "Modified Glutamatergic Postsynapse in Neurodegenerative Disorders". Neuroscience (2021): http://dx.doi.org/10.1016/j.neuroscience.2019.12.002.
    Published • 10.1016/j.neuroscience.2019.12.002
  8. Silva, DF; Candeias, E; Esteves, AR; Magalhães, JD; Ferreira, IL; Nunes-Costa, D; Rego, AC; Empadinhas, N; Cardoso, SM. "Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer's disease features in cortical neurons". Journal of Neuroinflammation 17 1 (2020): 332. http://dx.doi.org/10.1186/s12974-020-02004-y.
    Published • 10.1186/s12974-020-02004-y
  9. Ferreiro, E; Lanzillo, M; Canhoto, D; Carvalho da Silva, AM; Mota, SI; Dias, IS; Ferreira, IL; et al. "Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer's disease mouse model". Neurobiology of Aging 92 (2020): 98-113. http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.003.
    Published • 10.1016/j.neurobiolaging.2020.04.003
  10. Silva, AC; Ferreira, IL; Hayden, MR; Ferreiro, E; Rego, AC. "Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864 1 (2018): 34-44. http://dx.doi.org/10.1016/j.bbadis.2017.09.009.
    Published • 10.1016/j.bbadis.2017.09.009
  11. Naia, L; Ferreira, IL; Ferreiro, E; Rego, AC. "Mitochondrial Ca2+ handling in Huntington's and Alzheimer's diseases – Role of ER-mitochondria crosstalk". Biochemical and Biophysical Research Communications 483 4 (2017): 1069-1077. http://dx.doi.org/10.1016/j.bbrc.2016.07.122.
    10.1016/j.bbrc.2016.07.122
  12. Mota, SI; Costa, RO; Ferreira, IL; Santana, I; Caldeira, GL; Padovano, C; Fonseca, AC; et al. "Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852 7 (2015): 1428-1441. http://dx.doi.org/10.1016/j.bbadis.2015.03.015.
    Published • 10.1016/j.bbadis.2015.03.015
  13. Ferreira, IL; Ferreiro, E; Schmidt, J; Cardoso, JM; Pereira, CM; Carvalho, AL; Oliveira, CR; Rego, AC. "Aß and NMDAR activation cause mitochondrial dysfunction involving ER calcium release". Neurobiology of Aging 36 2 (2015): 680-692. http://dx.doi.org/10.1016/j.neurobiolaging.2014.09.006.
    Published • 10.1016/j.neurobiolaging.2014.09.006
  14. Nunes, JB; Peixoto, J; Soares, P; Maximo, V; Carvalho, S.; Pinho, SS; Vieira, AF; et al. "OXPHOS dysfunction regulates integrin- 1 modifications and enhances cell motility and migration". Human Molecular Genetics 24 7 (2014): 1977-1990. http://dx.doi.org/10.1093/hmg/ddu612.
    Published • 10.1093/hmg/ddu612
  15. Mota, SI; Ferreira, IL; Valero, J; Ferreiro, E; Carvalho, AL; Oliveira, CR; Rego, AC. "Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus — Linking NMDA receptors and the reelin pathway". Experimental Neurology 261 (2014): 698-709. http://dx.doi.org/10.1016/j.expneurol.2014.07.023.
    Published • 10.1016/j.expneurol.2014.07.023
  16. Naia, L; Ferreira, IL; Cunha-Oliveira, T; Duarte, AI; Ribeiro, M; Rosenstock, TR; Laço, MN; et al. "Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts". Molecular Neurobiology 51 1 (2014): 331-348. http://dx.doi.org/10.1007/s12035-014-8735-4.
    Published • 10.1007/s12035-014-8735-4
  17. Mota, SI; Ferreira, IL; Rego, AC. "Dysfunctional synapse in Alzheimer's disease: A focus on NMDA receptors". Neuropharmacology 76 (2014): 16-26. http://dx.doi.org/10.1016/j.neuropharm.2013.08.013.
    Published • 10.1016/j.neuropharm.2013.08.013
  18. Caldeira, GL; Ferreira, IL; Rego, AC. "Impaired transcription in Alzheimer's disease: key role in mitochondrial dysfunction and oxidative stress". Journal of Alzheimer's Disease 34 1 (2013): 115-131. https://doi.org/10.3233/jad-121444.
    Published • 10.3233/JAD-121444
  19. Ribeiro, M; Rosenstock, TR; Cunha-Oliveira, T; Ferreira, IL; Oliveira, CR; Rego, AC. "Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells". Free Radical Biology and Medicine 53 10 (2012): 1857-1867. http://dx.doi.org/10.1016/j.freeradbiomed.2012.09.004.
    Published • 10.1016/j.freeradbiomed.2012.09.004
  20. Mota, SI; Ferreira, IL; Pereira, CM; Oliveira, CR; Rego, AC. "Amyloid-Beta Peptide 1-42 Causes Microtubule Deregulation through N-methyl-D-aspartate Receptors in Mature Hippocampal Cultures". Current Alzheimer Research 9 7 (2012): 844-856. http://dx.doi.org/10.2174/156720512802455322.
    Published • 10.2174/156720512802455322
  21. Costa, RO; Lacor, PN; Ferreira, IL; Resende, R; Auberson, YP; Klein, WL; Oliveira, CR; Rego, AC; Pereira, CM. "Endoplasmic reticulum stress occurs downstream of GluN2B subunit ofN-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers". Aging Cell 11 5 (2012): 823-833. http://dx.doi.org/10.1111/j.1474-9726.2012.00848.x.
    Published • 10.1111/j.1474-9726.2012.00848.x
  22. Ferreira, IL; Bajouco, LM; Mota, SI; Auberson, YP; Oliveira, CR; Rego, AC. "Amyloid beta peptide 1–42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures". Cell Calcium 51 2 (2012): 95-106. http://dx.doi.org/10.1016/j.ceca.2011.11.008.
    Published • 10.1016/j.ceca.2011.11.008
  23. Ferreiro, E; Baldeiras, I; Ferreira, IL; Costa, RO; Rego, AC; Pereira, CM; Oliveira, CR. "Mitochondrial- and Endoplasmic Reticulum-Associated Oxidative Stress in Alzheimer's Disease: From Pathogenesis to Biomarkers". International Journal of Cell Biology 2012 (2012): 1-23. http://dx.doi.org/10.1155/2012/735206.
    Published • 10.1155/2012/735206
  24. Cardoso, SM; Ribeiro, M; Ferreira, IL; Rego, AC. "Northeast Portuguese propolis protects against staurosporine and hydrogen peroxide-induced neurotoxicity in primary cortical neurons". Food and Chemical Toxicology 49 11 (2011): 2862-2868. http://dx.doi.org/10.1016/j.fct.2011.08.010.
    Published • 10.1016/j.fct.2011.08.010
  25. Rosenstock, TR; de Brito, OM; Lombardi, V; Louros, S; Ribeiro, M; Almeida, S; Ferreira, IL; Oliveira, CR; Rego, AC. "FK506 ameliorates cell death features in Huntington’s disease striatal cell models". Neurochemistry International 59 5 (2011): 600-609. http://dx.doi.org/10.1016/j.neuint.2011.04.009.
    Published • 10.1016/j.neuint.2011.04.009
  26. Ferreira, IL; Cunha-Oliveira, T; Nascimento, MV; Ribeiro, M; Proença, MT; Januário, C; Oliveira, CR; Rego, AC. "Bioenergetic dysfunction in Huntington's disease human cybrids". Experimental Neurology 231 1 (2011): 127-134. https://doi.org/10.1016/j.expneurol.2011.05.024.
    Published • 10.1016/j.expneurol.2011.05.024
  27. Ferreira, IL; Resende, R; Ferreiro, E; Rego, AC; Pereira, CM. "Multiple Defects in Energy Metabolism in Alzheimers Disease". Current Drug Targets 11 10 (2010): 1193-1206. http://dx.doi.org/10.2174/1389450111007011193.
    Published • 10.2174/1389450111007011193
  28. Ferreira, IL; Nascimento, MV; Ribeiro, M; Almeida, S; Cardoso, SM; Grazina, M; Pratas, J; et al. "Mitochondrial-dependent apoptosis in Huntington's disease human cybrids". Experimental Neurology 222 2 (2010): 243-255. http://dx.doi.org/10.1016/j.expneurol.2010.01.002.
    Published • 10.1016/j.expneurol.2010.01.002
  29. Esteves, AR; Domingues, AF; Ferreira, IL; Januário, C; Swerdlow, RH; Oliveira, CR; Cardoso, SM. "Mitochondrial function in Parkinson’s disease cybrids containing an nt2 neuron-like nuclear background". Mitochondrion 8 3 (2008): 219-228. http://dx.doi.org/10.1016/j.mito.2008.03.004.
    Published • 10.1016/j.mito.2008.03.004
  30. Ferreira, IL; Duarte, CB; Carvalho, AP. "Kainate-induced retina amacrine-like cell damage is mediated by AMPA receptors". NeuroReport 9 15 (1998): 3471-3475. http://dx.doi.org/10.1097/00001756-199810260-00025.
    Published • 10.1097/00001756-199810260-00025
  31. Ferreira, IL; Duarte, CB; Neves, AR; Carvalho, AP. "Culture medium components modulate retina cell damage induced by glutamate, kainate or “chemical ischemia”". Neurochemistry International 32 4 (1998): 387-396. http://dx.doi.org/10.1016/s0197-0186(97)00099-5.
    Published • 10.1016/s0197-0186(97)00099-5
  32. Duarte, CB; Ferreira, IL; Santos, PF; Carvalho, AL; Agostinho, PM; Carvalho, AP. "Glutamate in Life and Death of Retinal Amacrine Cells". General Pharmacology: The Vascular System 30 3 (1998): 289-295. http://dx.doi.org/10.1016/s0306-3623(97)00360-1.
    Published • 10.1016/s0306-3623(97)00360-1
  33. Ferreira, IL; Duarte, CB; Carvalho, AP. "'Chemical ischemia' in cultured retina cells: The role of excitatory amino acid receptors and of energy levels on cell death". Brain Research 768 1-2 (1997): 157-166. https://doi.org/10.1016/s0006-8993(97)00634-3.
    Published • 10.1016/S0006-8993(97)00634-3
  34. Ferreira, IL; Duarte, CB; Carvalho, AP. "Ca2+ influx through glutamate receptor-associated channels in retina cells correlates with neuronal cell death". European Journal of Pharmacology 302 1-3 (1996): 153-162. http://dx.doi.org/10.1016/0014-2999(96)00044-1.
    Published • 10.1016/0014-2999(96)00044-1
  35. Carvalho, AP; Ferreira, IL; Carvalho, AL; Duarte, CB. "Glutamate Receptor Modulation of [3H]GABA Release and Intracellular Calcium in Chick Retina Cellsa". Annals of the New York Academy of Sciences 757 1 (1995): 439-456. http://dx.doi.org/10.1111/j.1749-6632.1995.tb17504.x.
    Published • 10.1111/j.1749-6632.1995.tb17504.x
  36. Carvalho, CM; Ferreira, IL; Duarte, CB; Malva, JO; Tretter, L; Adam-Vizi, V; Carvalho, AP. "Relation of [Ca2+]i to dopamine release in striatal synaptosomes: role of Ca2+ channels". Brain Research 669 2 (1995): 234-244. https://doi.org/10.1016/0006-8993(94)01252-d.
    10.1016/0006-8993(94)01252-d
  37. Alfonso, M; Duran, R; Duarte, CB; Ferreira, IL; Carvalho, AP. "Domoic acid induced release of [3H]GABA in cultured chick retina cells". Neurochemistry International 24 3 (1994): 267-274. https://doi.org/10.1016/0197-0186(94)90084-1.
    Published • 10.1016/0197-0186(94)90084-1
  38. Ferreira, I.L.; Duarte, C.B.; Santos, P.F.; Carvalho, C.M.; Carvalho, A.P.. "Release of [3H]GABA evoked by glutamate receptor agonists in cultured chick retina cells: effect of Ca2+". Brain Research 664 1-2 (1994): 252-256. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028172872&partnerID=MN8TOARS.
    10.1016/0006-8993(94)91981-x
  39. Duarte, C.B.; Ferreira, I.L.; Santos, P.F.; Oliveira, C.R.; Carvalho, A.P.. "Glutamate increases the [Ca2+]i but stimulates Ca2+-independent release of [3H]GABA in cultured chick retina cells". Brain Research 611 1 (1993): 130-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027335488&partnerID=MN8TOARS.
  40. Duarte, CB; Ferreira, IL; Carvalho, AP; Carvalho, CM. "Relation of exocytotic release of ¿-aminobutyric acid to Ca2+ entry through Ca2+ channels or by reversal of the Na+/Ca2+ exchanger in synaptosomes". Pflügers Archiv European Journal of Physiology 423 3-4 (1993): 314-323. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027263283&partnerID=MN8TOARS.
    Published • 10.1007/BF00374411
  41. Duarte, CB; Ferreira, IL; Santos, PF; Oliveira, CR; Carvalho, AP. "Ca2+-dependent release of [3H]GABA in cultured chick retina cells". Brain Research 591 1 (1992): 27-32. http://dx.doi.org/10.1016/0006-8993(92)90974-e.
    Published • 10.1016/0006-8993(92)90974-e
  42. Regateiro, FJ; Carvalho, CM; Ferreira, IL; Bairos, VA; Carvalho, AP. "Calcium stores in electropermeabilized HL-60 cells before and after differentiation". Cellular Signalling 3 1 (1991): 41-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026064436&partnerID=MN8TOARS.
    Published • 10.1016/0898-6568(91)90006-g
  43. Duarte, CB; Carvalho, CM; Ferreira, IL; Carvalho, AP. "Synaptosomal [Ca2+]i as influenced by Na+ Ca2+ exchange and K+ depolarization". Cell Calcium 12 9 (1991): 623-633. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025917963&partnerID=MN8TOARS.
    Published • 10.1016/0143-4160(91)90059-n
  44. Carvalho, AP; Bandeira-Duarte, C.; Ferreira, I.L.; Coutinho, O.P.; Carvalho, CM. "Sodium-calcium exchange in nerve terminals: Influence on internal Ca2+ and neurosecretion". Annals of the New York Academy of Sciences 639 (1991): 300-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026377475&partnerID=MN8TOARS.
  45. Carvalho, CM; Duarte, CB; Ferreira, IL; Carvalho, AP. "Regulation of carrier-mediated and exocytotic release of [3H]GABA in rat brain synaptosomes". Neurochemical Research 16 7 (1991): 763-772. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025820698&partnerID=MN8TOARS.
    Published • 10.1007/BF00965685
  46. Regateiro, FJ; Ferreira, IL; Carvalho, AP. "Isolamento e caracterização da sub-linha celular HL-60/R, resistente à diferenciação pelo ácido retinóico (A.R), derivada da linha celular promielocítica humana HL-60". Coimbra Médica 10 (1989): 236.
    Published
Newspaper article
  1. "Viagens sem insónias", Público, 2018, https://www.publico.pt/2018/03/16/ciencia/fotogaleria/viagens-sem-insonias-381315.
Thesis / Dissertation
  1. Ferreira, IL. "Toxicidade em células amácrinas da retina em cultura: envolvimento dos receptores ionotrópicos do glutamato em ambientes excitotóxicos". PhD, Universidade de Coimbra, 2003.
  2. Ferreira, IL. "Regulação da libertação de [3H]GABA por receptores do glutamato em células da retina em cultura". Master, Universidade de Coimbra, 1993.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/07/02 Transcriptional modulation of ER-mitochondria associated proteins and Ca2+ crosstalk induced by histone deacetylase inhibitors in Alzheimer’s disease 35ª Meeting of the Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD)
2019/10/18 Atividade mitocondrial e antioxidante em doentes com diabetes mellitus e periodontite XXXIX Anual Meeting Sociedade Portuguesa de Estomatologia e Medicina Dentária (SPEMD)
(Porto, Portugal)
2019/10/11 Class I histone deacetylase inhibitors modify mitochondrial function in cell models of Alzheimer's disease 33ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD)
(Coimbra, Portugal)
2019/10/11 Characterization of SAPAP3 scaffold postsynaptic protein and its involvement in mitochondrial dysfunction in Huntington’s disease 33th Meeting of the Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD)
(Coimbra, Portugal)
2017/10/13 Níveis de resistina e de peróxido de hidrogénio em doentes com diabetes e periodontite XXXVII Anual Meeting Sociedade Portuguesa de Estomatologia e Medicina Dentária (SPEMD)
(Coimbra, Portugal)
2017/03/17 Mitochondrial deregulation in striatum and cortex of pre-symptomatic and symptomatic Huntington’s disease mouse model Congresso da Sociedade Portuguesa das Doenças do Movimento (SPDMov) 2017
(Ofir, Portugal)
2017/03/17 Mitochondria in Machado-Joseph disease: alterations in function and dynamics Congresso da Sociedade Portuguesa das Doenças do Movimento (SPDMov) 2017
(Ofir, Portugal)
2017/02/02 Machado-Joseph disease models exhibit compromised mitochondrial function and dynamics XLVII Annual Meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2016/06/03 Defeitos bioenergéticos no estriado e no córtex nas fases pré-sintomáticas e sintomáticas do modelo animal YAC128 para a doença de Huntington 30ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Lisboa, Portugal)
2016/06/03 Compromised mitochondrial function in cell and animal models of Machado-Joseph disease 30ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD)
(Lisboa, Portugal)
2016/02/04 Redox deregulation in pre-symptomatic and symptomatic stages of Huntington’s disease mouse model XLVI Annual Meeting of the Portuguese Society of Pharmacology
(Porto, Portugal)
2015/12/17 Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer’s disease XIII Encontro Anual do Centro de Neurociências e Biologia Celular
(Coimbra, Portugal)
2015/05/29 Elevação dos níveis cerebrais de peróxido de hidrogénio num modelo transgénico da doença de Alzheimer 29ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD)
(Aveiro, Portugal)
2014/06/27 Aß and NMDAR activation cause mitochondrial dysfunction involving ER calcium release 28ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Aveiro, Portugal)
2014/06/27 Linking NMDA receptors and the reelin pathway in Alzheimer’s disease 28ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Aveiro, Portugal)
2013/06/30 Altered NMDA receptor and Src related signaling in Alzheimer’s disease XIII Meeting of the Portuguese Society for Neurosciences (SPN)
(Luso, Portugal)
2013/05/30 Oxidative and ER stress in early stages of Alzheimer’s disease XIII Meeting of the Portuguese Society for Neurosciences (SPN)
(Luso, Portugal)
2012/06/29 Changes in oxidative and endoplasmic reticulum stress in human peripheral blood mononuclear cells during early stages of Alzheimer’s disease 26ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Tomar, Portugal)
2011/06/03 Amyloid-ß 1-42 oligomers induce cytosolic Ca2+ increase and mitochondrial depolarization through NR2B-containing NMDARs in cortical neurons 25ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Tomar, Portugal)
2011/06/03 Bioenergetic dysfunction in Huntington´s disease human cybrids 25ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Tomar, Portugal)
2011/06/03 Pathological changes detected in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease individuals 25ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Tomar, Portugal)
2010/12/20 Alzheimer’s disease-associated amyloid-beta peptide oligomers induce endoplasmic reticulum stress through N-methyl-D-aspartate receptors in hippocampal neurons VIII Encontro Anual do Centro de Neurociências e Biologia Celular
(Coimbra, Portugal)
2010/06/25 Changes in NMDA receptor subunits expression in 3xTg-AD mice and human peripheral blood cells 24ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Tomar, Portugal)
2010/06/25 Creation and characterization of mitochondrial DNA depleted human HD derived lymphoblasts 24ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Tomar, Portugal)
2010/06/25 Loss of endoplasmic reticulum calcium homeostasis in Alzheimer’s disease 24ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Tomar, Portugal)
2010/04/11 Northeast portuguese propolis protects against neurotoxic events in cerebral cortical neurons Trends in Natural Products Research - Phytochemical Society of Europe (PSE) Young Scientists Meeting 2010
(Leicester, United Kingdom)
2009/12/21 Analysis of cell degeneration in models of Huntington’s and Alzheimer’s disease VII Encontro Anual do Centro de Neurociências e Biologia Celular
(Cantanhede, Portugal)
2009/12/21 Intracellular calcium responses induced by amyloid beta peptide oligomers and NMDA receptor activation in rat cortical neurons XXXIX Annual Meeting of the Portuguese Society of Pharmacology
2009/12/02 Amyloid-beta peptide oligomers induce early microtubule disassembly and mild degeneration in mature rat hippocampal neurons XXXIX Reunião da Sociedade Portuguesa de Farmacologia e XXVI Reunião de Farmacologia Clínica
(Porto, Portugal)
2009/06/26 Altered beta III-tubulin levels in mature hippocampal neurons exposed to oligomers of amyloid-beta peptide 23ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Luso, Portugal)
2007/10/26 Changes in energy metabolism and apoptosis in Huntington's disease cybrids Reunião Da Secção de Doenças do Movimento da SPN
(Figueira da Foz, Portugal)
2007/10/10 Oxidative stress in striatal cells expressing mutant huntingtin and in Huntington’s disease cybrids Society for Free Radical Research (SFRR) Europe
(Vila Moura, Portugal)
2006/12/05 Mitochondrial dysfunction enhances MPP+ induced toxicity in Parkinson disease cybrids XXXVII Reunião da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica
(Porto, Portugal)
2006/12/05 Evidence of oxidative stress and apoptosis in Huntington’s disease cybrids and striatal cells XXXVII Reunião da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica
(Porto)
2006/10/13 Mitochondrial dysfunction enhances MPP+ toxic effects in Parkinson’s disease cybrids. Reunião Da Secção de Doenças do Movimento da SPN
(Fermentelos, Portugal)
2006/10/13 Evidências de stress oxidativo e apoptose em modelos celulares da doença de Huntington Reunião da Secção de Doenças do Movimento da SPN
(Fermentelos, Portugal)
2004 Glutamatergic signalling is involved in the processing of APP II Simposium de Pós-Graduação, Department of Biology, University of Aveiro
(Aveiro, Portugal)
1997/04/11 Retinal cell death under chemical ischemia and excitotoxicity Series in Basic Mechanisms Related to Stress, Ischaemia and Neuroprotection in Retina
(Coimbra, Portugal)
1996/01/19 Glutamate neurotoxicity in cultured chick retina cells IInd International Symposium on Experimental Techniques
(Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020 - Current Targeting class I and II histone deacetylases as therapeutic strategy to treat mitochondrial dysfunction in Alzheimer’s disease
Co-supervisor of Daniela Marinho Lopes
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - 2020 Boldine prevents Aß1-42 oligomers-induced toxicity and mitochondrial dysfunction in HT22 cells
Co-supervisor of Juan Pablo Toledo Hormazabal
 Grado de Ingeniero en Biotecnología Vegetal
Universidad de Concepción, Chile
2018 - 2019 Role of amyloid-beta peptide on calcium and mitochondrial dyshomeostasis in hippocampal neurons: influence of histone deacetylases
Co-supervisor of Daniela Marinho Lopes
 Neurobiologia (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2019 Mitochondrial respiratory chain complexes and antioxidant enzymes analyses in diabetes and chronic periodontitis-derived human blood mononuclear cells
Co-supervisor of Olga Fokt
 Medicina Dentária (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2019 Role of class I histone deacetylase inhibitors in 3xTg-AD mice
Co-supervisor of Vera Cristina Martinho Pais
 Biologia Molecular e Celular (Master)
Universidade de Aveiro Departamento de Biologia, Portugal
2017 - 2018 Characterization of striatal postsynaptic density in a transgenic mouse model of Huntington’s disease
Co-supervisor of Diogo André Malheiro de Passos
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2017 Mitochondrial function analysis in diabetes and chronic periodontitis-derived human blood cells: role of resistin
Co-supervisor of Ana Solange Gomes Costa
 Medicina Dentária (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016 - 2017 Characterization of SAPAP3 in Huntington’s disease: focusing on postsynaptic density
Co-supervisor of Patrícia Lino
 Master 2 Recherche Biologie (Master)
Université Fançois Rabelais , France

Université Paris Descartes et Paris Diderot, France
2015 - 2016 Early mitochondrial modifications in YAC128 transgenic model of Huntington’s disease
Co-supervisor of Carina Sofia Barradas Maranga
 Biologia Celular e Molecular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2015 Study of oxidative stress and mitochondrial alterations in an animal model of Huntington’s disease
Co-supervisor of Maura de Rosa
 Biology (Master)
Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Italy
2012 - 2013 Aß-mediated changes in CREB and ERK activity in cultured cortical neurons: involvement of NMDA receptors
Co-supervisor of Valeria de Rosa
 Biology (Master)
Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Italy
2008 - 2013 NMDA receptors-associated events and oxidative stress in models of Alzheimer’s disease
Co-supervisor of Sandra Isabel Freitas Mota
 Biologia Celular (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2012 Changes in transcription factors related to mitochondrial biogenesis and antioxidant defenses in Alzheimer’s disease models
Co-supervisor of Gladys Tarcila Lima Caldeira
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2012 Pyruvate dehydrogenase and mitochondrial function in Huntington’s disease – influence of histone deacetylase inhibitors
Co-supervisor of Joana Cristina Pedro Rodrigues
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2010 Studies in human mononuclear cells obtained from different stages of mild cognitive impairment in Alzheimer’s disease: the role of memantine therapy
Co-supervisor of Carmela Padovano
 Biology (Master)
Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Italy
2009 - 2010 Creation and characterization of mitochondrial DNA-depleted human Huntington´s disease and control derived lymphoblasts
Co-supervisor of Maria João Rodrigues Ferreira Ribeiro
 Biotecnologia para as Ciências da Saúde (Master)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2009 - 2010 Amyloid beta peptide 1-42 oligomers disturb intracellular calcium homeostasis through activation of N-methyl-D-aspartate receptors in Alzheimer’s disease – a role for NR2A and NR2B subunits
Supervisor of Luís Miguel Morais Calado de Oliveira Bajouco
 Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2009 - 2010 Role of NMDA receptor in cortical neurons exposed to amyloid beta peptide
Co-supervisor of Chiara d’Amatti
 Biology (Master)
Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Italy
2007 - 2008 Alterações do metabolismo energético e a susceptibilidade à morte celular de cíbridos da doença de Huntington
Co-supervisor of Maria Martins Viegas Nascimento
 Biologia Celular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016/03/01 - 2016/03/01 XIX Encontro Nacional de Estudantes de Biologia "Os sinaptossomas como modelo da disfunção pré-sináptica em patologias do cérebro - o papel da mitocôndria" (2016)
Workshop (Co-organisor)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/09/02 - 2019/09/06 Ciência Viva no Laboratório - Ocupação Científica de Jovens nas Férias, Henrique Louro e Miriam Neves, Escola Joaquim de Carvalho, Figueira da Foz, at MiNDlab-Mitochondria and Neurodegenerative Disorders group Ciência Viva no Laboratório
Ciência Viva, Portugal
2019/03/25 - 2019/03/25 Brain Awareness Week 2019, a short play about the brain with the plastic artist Mónica Garcia (Jardim de Infância dos Serviços de Acção Social da Universidade de Coimbra (SASUC), Coimbra) Brain Awareness Week 2019
Ciência Viva, Portugal
2019/03/14 - 2019/03/14 Brain Awareness Week 2019, "A Hora do Cérebro - A Hora de Praticar o Certo" (Jardim Escola da Solum, Coimbra) Brain Awareness Week 2019
Ciência Viva, Portugal
2016/09/26 - 2016/10/03 Alzheimer's Day 2016, “Curiosidades sobre o Cérebro” (Lar Conde de Sucena da Santa Casa da Misericórdia de Águeda, Águeda) Alzheimer's Day 2016
Santa Casa da Misericórdia de Águeda, Portugal
2013/09/27 - 2013/09/27 European Researchers Night 2013 - O Futuro, "Speed dating com cientistas" (Coimbra) European Researchers Night 2013
Universidade de Coimbra, Portugal
2013/03/12 - 2013/03/12 Brain Awareness Week 2013 (Externato Grão Vasco, Lisboa) Brain Awareness Week 2013
Ciência Viva, Portugal
2012/09/28 - 2012/09/28 European Researchers Night 2012 - Ciência e Desporto, hands-on activities (Coimbra) European Researchers Night 2012
Universidade de Coimbra, Portugal
2010/09/24 - 2010/09/24 European Researchers Night 2010 - Cientistas ao Palco, "Speed dating com cientistas" (Coimbra) European Researchers Night 2010
Universidade de Coimbra, Portugal
2010/06/17 - 2010/06/17 Semana Cultural, "Cultura Científica para Miúdos" (Escola EB1,2 Fernando Caldeira, Águeda) Semana Cultural da Escola EB1,2 Fernando Caldeira
2010/03/18 - 2010/03/18 Brain Awareness Week 2010 (Jardim-de-infância A Casa da Avó, Coimbra) Brain Awareness Week 2010
Ciência Viva, Portugal
2009/09/25 - 2009/09/25 European Researchers Night 2009 - Cientistas ao Palco, "Speed dating com cientistas" (Coimbra) European Researchers Night 2009
Universidade de Coimbra, Portugal
2009/03/18 - 2009/03/18 Brain Awareness Week 2009 (EB1 do Passadouro, Oliveira do Bairro) Brain Awareness Week 2009
Ciência Viva, Portugal
2009/03/16 - 2009/03/16 Brain Awareness Week 2009 (Externato João XXIII, Coimbra) Brain Awareness Week 2009
Ciência Viva, Portugal
2008/11/26 - 2008/11/26 Science and Technology Week 2008, "O cérebro e Nós: da Anatomia ao Comportamento" (Escola EB 2,3 de Oliveira do Bairro) Science and Technology Week 2008
Ciência Viva, Portugal
2008/06/19 - 2008/06/19 Semana Cultural, "O cérebro e Nós: da Anatomia ao Comportamento" (Escola EB1,2 Fernando Caldeira, Águeda) Semana Cultural da Escola EB1,2 Fernando Caldeira
2006/03/16 - 2006/03/16 Brain Awareness Week 2006 (EB1 de Águeda, Águeda) Brain Awareness Week 2006
Ciência Viva, Portugal
2006/03/14 - 2006/03/14 Brain Awareness Week 2006 (EBI Santa Cruz da Trapa, Vouzela) Brain Awareness Week 2006
Ciência Viva, Portugal
2001 - 2003 Collaboration in “Programa Ciência Viva e Saúde no Século XXI” (laboratory classes) Programa Ciência Viva e Saúde no Século XXI
Ciência Viva, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/12/12 Differential regulation of GluN2A- and GluN2B-containing NMDA receptors by BDNF in the plasticity of hippocampal synapses
Thesis Member
 Pasqualino De Luca (PhD)
2022/06/30 P2Y1-CRMP2-NMDARs: A novel mechanistic hypothesis for glutamate-induced neurodegeneration
(Thesis) Main arguer
 Matilde Partidário Martins de Jesus (Master)
2020 Disfunctional dendritic and axonal activity in Alzheimer´s disease – identifying possible therapeutic targets
(Thesis) Main arguer
 Alexandra Lopes Ramos Rodrigues (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 Regulation of NMDA receptor dynamics by BDNF in cultured neurons
(Thesis) Main arguer
 Rafael da Silva Carvalho (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 NMDA receptors-associated events and oxidative stress in models of Alzheimer’s disease
Thesis Member
 Sandra Isabel Freitas Mota (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 Análise protetora de derivados de luteolina num modelo de Huntington
(Thesis) Main arguer
 Ana Margarida Alves de Oliveira (Master)
Universidade de Aveiro Departamento de Química, Portugal
2010 Role of insulin and IGF-1 in energy metabolism in Huntington’s disease: studies in cortical ans striatal neurons from YAC128 transgenic mice and human lymphoblasts
(Thesis) Main arguer
 Luana Carvalho Naia (Master)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2010 Creation and characterization of mitochondrial DNA-depleted human Huntington´s disease and control derived lymphoblasts
Thesis Member
 Maria João Rodrigues Ferreira Ribeiro (Master)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2010 Amyloid beta peptide 1-42 oligomers disturb intracellular calcium homeostasis through activation of N-methyl-D-aspartate receptors in Alzheimer’s disease – a role for NR2A and NR2B subunits
Thesis Member
 Luís Miguel Morais Calado de Oliveira Bajouco (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2021 - Current Portuguese Society for Neuroscience (SPN) Effective Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021 - Current Mechanisms of Neuronal Dysfunction and Neurodegeneration Neurociências Molecular e de Translação (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2016 - 2017 Investigação Aplicada II - Carlos Bernardo Albuquerque Fernandes Braz Saraiva (Modificações da proteína SAPAP3 na densidade pós-sináptica na doença de Huntington) Medicina (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2016 - 2016 Calcium deregulation in Alzheimer’s disease CNC-IBILI Seminars Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2016 Patient-derived cells to study the molecular mechanisms in early AD Investigação Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2016 Investigação Aplicada I - Pedro Miguel da Silva Teixeira (Análise dos níveis proteicos de SAPAP3 e Shank3 no estriado do murganho YAC128) Medicina (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2015 Neurodegenerative disorders (Mechanisms of neuronal dysfunction - Excitotoxicity) Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2011 - 2015 Neurosciences Medicina (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - 2013 Neurobiologia II (Influence of amyloid-beta peptide involving the NMDA receptor) Engenharia Biomédica Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2011 Investigação II - Maria Inês Domingues Laranjinha (Resveratrol em cíbridos de Huntington: potencial modulador do estado redox e padrão metabólico) Medicina (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - 2011 Investigação III - Maria Lúcia Faria Moleiro (Disfunção mitocondrial e neuroprotecção em modelos de Neurodegenerescência) Medicina (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - 2010 Analysis of cell death in neuroblastoma cells subjected to Abeta1-42 oligomers, H2O2, staurosporine or rotenone: effect of hypoglycaemia achieved by glucose deprivation Advanced course in mammalian and yeast as complementary cell models in programmed cell death Universidade do Minho, Portugal
2007 - 2009 Neurosciences Medicina (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2002 - 2003 Immunology Ciências Farmacêuticas (Mestrado integrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
1991 - 1999 Cell and Molecular Biology Biologia Celular (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1990 - 1999 Neurobiology II Biologia (Licenciatura)/ Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1990 - 1999 Neurobiology I Biologia (Licenciatura)/ Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1997 - 1998 Animal Physiology II Biologia (Licenciatura)/ Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1990 - 1990 Laboratory courses International Advanced Course: Cell Secretion and Cell Signalling Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

ICRO (International Cell Research Organization), UNESCO, United States
1989 - 1990 Animal Physiology I Biologia (Licenciatura)/ Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1989 - 1990 Histology and Embryology Biologia (Licenciatura)/ Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2015/12/17 - 2015/12/18 Participation in the Poster Evaluation Panels at XIII CNC Annual Meeting, Coimbra. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2024 - Current International Immunopharmacology
2022 - Current Frontiers in Aging Neuroscience
2019 - Current Neuroscience Elsevier
2015 - Current Journal of Alzheimer's Disease IOS Press
2014 - Current Clinical Research in HIV/ AIDS JSciMed Central
2014 - Current British Journal of Pharmacology Wiley-Blackwell
2014 - Current Biochimica et Biophysica Acta (BBA) Elsevier

Mentoring / Tutoring

Topic Student name
2020 - 2021 Supervision of Laboratory Rotations Mariana Cunha Pires
2019 - 2020 Supervision of Laboratory Rotations Catarina Carreira
2019 - 2020 Supervision of Laboratory Rotations Revathi Thirumushi Sairaj
2019 - 2020 Supervision of Laboratory Rotations Riccardo Vida
2018 - 2019 Supervision of Laboratory Rotations Jessica Hunger
2017 - 2018 Supervision of Laboratory Rotations Erika di Pietro
2016 - 2017 Supervision of Laboratory Rotations Maria Raimundo
2015 - 2016 Supervision of Laboratory Rotations Patrícia Lino
2015 - 2016 Supervision of Laboratory Rotations Mariasilvia Colantuoni
2014 - 2015 Supervision of Laboratory Rotations Filipa Luísa Lourenço de Almeida
2014 - 2015 Supervision of Laboratory Rotations Deolinda Conceição Santinha
2013 - 2014 Supervision of Laboratory Rotations Catarina Caldeira Vaz
2012 - 2013 Supervision of Laboratory Rotations Elvira Pequeno Leites
2011 - 2012 Supervision of Laboratory Rotations Joana Cristina Pedro Rodrigues
2007 - 2008 Undergraduate Students Supervision Susana Ribeiro dos Louros
1995 - 1996 Undergraduate Students Supervision Ana Rute Neves
1991 - 1992 Undergraduate Students Supervision Paulo Fernando Martins dos Santos

Other jury / evaluation

Activity description Institution / Organization
2021/10 - 2021/10 Jury member for the award of a research grant with the reference "BIM EHDN2021 11592021/ACRego" Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/02 - 2021/02 Jury member for the award of a research grant with the reference "BIM 4.1.3. HealthyAging2020 (CENTRO-01-0145-FEDER-000012)/LUGUS714624" Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/11 - 2019/11 Jury member for the award of a research grant with the reference "BIM 4.1.1. HealthyAging2020 (CENTRO-01-0145-FEDER-000012)" Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/11 - 2019/11 Jury member for the award of a research grant with the reference "INV JR2019.50/2 Nº032316 " Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/12 - 2018/12 Jury member for the award of a research grant with the reference "BIM 4.2.1. HealthyAging2020 (CENTRO-01-0145-FEDER-000012)/LUGUS553043" Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/11 - 2018/11 Jury member for the award of a research grant with the reference "BID 4.1.2 Healthy Aging 2020 (CENTRO-01-0145-FEDER-000012)/LUGUS539331" Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/11 - 2018/11 Jury member for the award of a research grant with the reference "BIM 4.1.2. HealthyAging2020 (CENTRO-01-0145-FEDER-000012)" Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/09 - 2018/09 Jury member for the award of a research grant with the reference "BIM EHDN 948/ACREGO" Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Distinctions

Award

2021 Best Poster
European Society for Clinical Investigation, Netherlands
2019 Best Poster
European Society for Clinical Investigation, Netherlands
2019 Best Oral Communication
Sociedade Portuguesa de Estomatologia e Medicina Dentária (SPEMD), Portugal
2017 Best Oral Communication
Sociedade Portuguesa de Estomatologia e Medicina Dentária (SPEMD), Portugal
2011 Best Poster
Janssen Pharmaceutica NV, Belgium
2011 Best Poster
Universidade de Coimbra-Faculdade de Medicina, Portugal