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Rui started his academic journey in 2015 in the University of Porto, where he obtained a BSc (2018) and MSc (2020) in Biochemistry by the Faculty of Sciences and Instituto Ciências Biomédicas Abel Salazar. In 2021 started his PhD in the Doctoral Program In Chemistry by the University of Porto, focused on the development of temperature sensitive hybrid hydrogels for the treatment of skin-cancer. He has an interest in physical chemistry, self-assembled colloidal systems, drug-delivery, biochemistry, and nanotechnology. Rui is proficient in a wide variety of experimental techniques such as: polarized light and fluorescence microscopy, rheology, fluorimetry, dynamic and electrophoretic light scattering, differential scanning calorimetry, surface tension measurements, and cell culture. He has a genuine interest in sharing his scientific research with the scientific community and thus has participated in a number of national and international scientific conferences, presenting posters and flash communications. Rui has also co-authored a research paper entitled “Stimuli Sensitive Nanotubules Based on Lysine Derivatives for Delivery of Antimicrobial Proteins” Additionally, he has also participated in several activities aiming to share scientific knowledge with high school students to foment their interest in scientific research.
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Identification

Personal identification

Full name
Rui Pedro Leal Machado

Citation names

  • Machado, R. L.
  • Rui L. Machado

Author identifiers

Ciência ID
691C-1D0C-0333
ORCID iD
0000-0003-3730-6161

Email addresses

  • ruilealmachado@hotmail.com (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Chemical Sciences - Physical Chemistry
  • Exact Sciences - Chemical Sciences - Colloid Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2021/10/01 - 2025/10/01
Ongoing
 Programa Doutoral em Química (Doutoramento)
Major in Química de Coloides
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
2018 - 2020
Concluded
 Bioquímica (Mestrado)
Major in Ciências Biológicas, Química
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Catanionic surfactant systems based on lysine derivatives for encapsulation of Cynara cardunculus extracts, aprovado com 18 valores." (THESIS/DISSERTATION)
 17
2015 - 2018
Concluded
 Bioquímica (Licenciatura)
Major in Ciências Biológicas, Química
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Encapsulação de proteínas por nanotubos sensíveis a estímulos, aprovado com 19 valores." (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2019/02 - 2019/07 Research Trainee (Research) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Centro de Investigação em Química, Portugal
Outputs

Publications

Conference abstract
  1. Dmitriy Moreira; Rui L. Machado; Raquel G. Lopes; Bárbara Abreu Brito e Faro; Isabel S. Oliveira; Eduardo F. Marques. "Amphiphiles as building blocks for the assembly of smart delivery vectors and advanced nanocomposites". Paper presented in IX Iberian Meeting on Colloids and Interfaces, Santiago de Compostela, 2022.
  2. Dmitriy Moreira; Pedro Ferreira; Rui L. Machado; Raquel G. Lopes; Catarina Costa; Bárbara Abreu; Isabel S. Oliveira; Eduardo F. Marques. "Amphiphile-based interfaces and self-assembled nanomaterials for diverse applications". Paper presented in CIQUP Workshop Meeting 2020, Porto, 2020.
    Published
Conference poster
  1. Rui L. Machado; Elsa Loureiro; Andreia Ferreira de Castro Gomes; Eduardo F. Marques (311B-EA0C-9491). Corresponding author: Eduardo F. Marques (311B-EA0C-9491). "Polymer/tubule hydrogels: structural, thermodynamic and rheological characterization". Paper presented in 16th National Meeting of Physical Chemistry, 2024.
  2. Rui L. Machado; Bruna Silva; Andreia Ferreira de Castro Gomes; Eduardo F. Marques (311B-EA0C-9491). "Creating stable nanocarriers from cationic/anionic surfactant mixtures for the delivery of bioactive C. cardunculus extracts". Paper presented in 10th Iberian Meeting on Colloids and Interfaces, 2024.
  3. Machado, R. L.; Andreia Ferreira de Castro Gomes; Maria João Araújo; E. F. Maqu. Corresponding author: E. F. Maqu. "Vesicles from cationic/anionic (catanionic) surfactant mixtures based on lysine derivatives: self-assembly and encapsulation of a bioactive molecule". Paper presented in 7th International Conference on Ionic Liquid Based Materials, 2023.
  4. E. Loureiro; Rui L. Machado; Andreia Ferreira de Castro Gomes; E. F. Marques. Corresponding author: E. F. Marques. "Stimuli-responsive hybrid polymer/lysine-surfactant hydrogels for topical drug delivery". Paper presented in 37th conference of European Colloid & Interface Society, 2023.
  5. E. Loureiro; Machado, R. L.; E. F. Marques. "Polymer/surfactant hydrogels for drug delivery; thermal and rheological characterization". Paper presented in 16th Mediterranean Conference on Calorimetry and Thermal Analysis, 2023.
  6. Rui L. Machado; Karenina Santos; I. S. Oliveira; Andreia C. Gomes; E. F. Marques. "A comparative assessment of the structural properties, cytotoxic profile, and anti-cancer activity of catanionic vesicles of diverse surfactant composition". Paper presented in IX Iberian Meeting on Colloids and Interfaces, 2022.
  7. Isabel S. Oliveira; Rui L. Machado; Andreia C. Gomes; Maria J. Araújo; Eduardo F. Marques (311B-EA0C-9491). "Dual-responsive tubule-based hydrogels for protein loading". Paper presented in 35th Conference of the European Colloid and Interface Society (ECIS), 2021.
  8. Rui L. Machado; Andreia C. Gomes; Maria J. Araújo; Eduardo F. Marques. "Catanionic vesicles from lysine-based surfactants for the delivery of bioactive plant extracts". Paper presented in 14º Encontro Nacional de Química Física, 2021.
  9. Rui L. Machado; Isabel S. Oliveira; Maria J. Araújo; Eduardo F. Marques. "Encapsulation and release of lysozyme by temperature/pH-responsive tubule-based hydrogels". Paper presented in 8th Iberian Meeting on Colloids and Interfaces (RICI8), 2019.
  10. Isabel S. Oliveira; Rui L. Machado; Maria J. Araújo; Andreia C. Gomes; Eduardo F. Marques. "Stimuli-sensitive Self-assembled Tubules based on Lysine-derived Surfactants as Nanocarriers for Proteins". Paper presented in 26th Encontro Nacional da Sociedade Portuguesa de Química, 2019.
  11. Isabel S. Oliveira; Rui L. Machado; Maria J. Araújo; Andreia C. Gomes; Eduardo F. Marques. "Protein loading by stimuli-sensitive tubules based on lysine surfactants". Paper presented in 32nd Conference of the European Colloid and Interface Society, 2018.
Journal article
  1. Isabel S. Oliveira; Rui L. Machado; Maria J. Araújo; Andreia C. Gomes; Eduardo F. Marques. "Stimuli-Sensitive Self-Assembled Tubules Based on Lysine-Derived Surfactants for Delivery of Antimicrobial Proteins". Chemistry – A European Journal 27 2 (2021): 692-704. http://dx.doi.org/10.1002/chem.202003320.
    Published • 10.1002/chem.202003320
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/06/25 Responsive polymer/surfactant hydrogels for topical drug delivery 10th Iberian Meeting on Colloids and Interfaces
Universidade de Coimbra (Coimbra, Portugal)
2021/07/14 Multi-composition biocompatible catanionic vesicles for the encapsulation and delivery of doxorubicin XXVII Encontro Nacional da Sociedade Portuguesa de Química
Universidade do Minho (Braga, Portugal)
2020/02/22 Amphiphile-based interfaces and self-assembled nanomaterials for diverse applications CIQUP Workshop Meeting 2020
Centro de Investigação em Química da Universidade do Porto (Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/07/17 - 2024/07/19 Participação e apresentação de poster científico na conferência 16th National Meeting of Physical Chemistry
Conference
 16th National Meeting of Physical Chemistry
Universidade de Lisboa, Portugal
2024/06/23 - 2024/06/26 Participação e apresentação oral de um poster científico na conferência 10th Iberian Meeting on Colloids and Interfaces
Conference
 10th Iberian Meeting on Colloids and Interfaces
Universidade de Coimbra, Portugal
2024/02/08 - 2024/02/10 Participação nos dias abertos FCUP - demonstrações científicas a alunos de 10º, 11º e 12º ano de escolaridade.
Other
 Dias Abertos FCUP
Universidade do Porto Faculdade de Ciências, Portugal
2023/11/21 - 2023/11/24 Participação e apresentação de poster científico no evento 7th International Conference on Ionic Liquid Based Materials
Conference
 7th International Conference on Ionic Liquid Based Materials
Universidade do Porto Faculdade de Ciências, Portugal
2023/07/19 - 2023/07/21 Participação e apresentação de poster científico no evento 16th Mediterranean Conference on Calorimetry and Thermal Analysis
Conference
 16th Mediterranean Conference on Calorimetry and Thermal Analysis
Universidade do Porto Faculdade de Ciências, Portugal
2023/07/10 - 2023/07/14 Participação "Escola da Química e Bioquímica" - Mentor de estudante em realização de pequeno projeto de investigação científica.
Other
 Escola da Química e Bioquímica
Universidade do Porto Faculdade de Ciências, Portugal
2023/02/09 - 2023/02/11 Participação nos dias abertos FCUP - demonstrações científicas a alunos de 10º, 11º e 12º ano de escolaridade.
Other
 Dias Abertos FCUP
Universidade do Porto Faculdade de Ciências, Portugal
2022/07/10 - 2022/07/13 Participação e apresentação de poster científico no evento IX Reunião Ibérica em Coloides e Interfaces (RICI9).
Conference
 IX Iberian Meeting on Colloids and Interfaces
Universidade de Santiago de Compostela, Spain
2021/03/29 - 2021/03/31 Participação e apresentação de poster científico no evento 14º Encontro Nacional de Química Física
Meeting
 14º Encontro Nacional de Química Física
Universidade de Coimbra, Portugal
2019/07/17 - 2019/07/19 Participação e apresentação de poster científico no evento VIII Iberian Meeting on Colloids and Interfaces (RICI8).
Congress
 8th Iberian Meeting on Colloids and Interfaces
Universidade de Aveiro, Portugal
2017/04/28 - 2017/04/29 IV Jornadas da Bioquímica - Série de palestras que abordaram a evolução do campo da Bioquímica, o seu ensino na Universidade do Porto e os atuais temas científicos mais preponderantes na área.
Other
 IV Jornadas da Bioquímica - "Bioquímica pelo tempo: 35 anos de evolução"
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Mentoring / Tutoring

Topic Student name
2023/01 - 2023/09/30 Tese de Mestrado - "Stimuli-responsive hybrid polymer/lysine-surfactant hydrogel for topical applications" Elsa Margarida Fonseca Cardoso Loureiro
2020/02 - 2020/07 Projeto de Licenciatura em Química - "Sistemas autoagregados baseados em misturas de tensioativos catiónicos e aniónicos para encapsulação de substâncias bioativas" Jorge Manuel Alves Monteiro