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Currently working as a Post-Doctoral Researcher at the Natural Bioactives & Nutraceuticals Area from iBET. Specialized in the bioactivity assessment of natural extracts and compounds for health applications, I have developed expertise in designing and conducting chemical, enzymatic, and cell-based assays to evaluate antioxidant, antiproliferative, anti-aging, and anti-inflammatory properties. My work also focuses on elucidating biological mechanisms of action using advanced cellular and molecular biology techniques. Throughout my journey at iBET, I have contributed to multidisciplinary teams in national and international projects, collaborating with leading research institutes and industry stakeholders. My efforts have supported the generation of impactful data to advance scientific development in nutraceuticals and health-related applications. I hold a BSc in Medicinal Chemistry from the University of Coimbra (2015), an MSc in Biochemistry for Health (2017), and a PhD in Molecular Biosciences from Instituto de Tecnologia Química e Biológica António Xavier, NOVA University of Lisbon (2024).
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Identification

Personal identification

Full name
Melanie Santos Matos

Citation names

  • Melanie S. Matos

Author identifiers

Ciência ID
691F-A6D5-38E3
ORCID iD
0000-0003-2093-791X

Email addresses

  • melanie.matos@ibet.pt (Professional)

Addresses

  • Instituto de Biologia Experimental e Tecnológica (iBET). Avenida da República, Qta. do Marquês, 2780-157, Oeiras, Oeiras, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences
  • Natural sciences - Biological Sciences - Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Elementary (A2) Upper intermediate (B2) Beginner (A1) Upper intermediate (B2)
Education
Degree Classification
2024/07/19
Concluded
 Biociências Moleculares (Doutoramento)
Major in Especialidade: Biologia
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
"Adding value to chicory roots: Evaluation of the anti-inflammatory potential of terpenes for application in Inflammatory Bowel Disease" (THESIS/DISSERTATION)
2023/03/27 - 2023/03/31
Concluded
 Experimental Data Analysis using Business Intelligence - 3rd Edition (Outros)
.what.if., Portugal
 Excellent (18-20/20)
2021/06/16 - 2021/06/18
Concluded
 Vector Graphics for Biologists (Outros)
Scistyle, Germany
2020/03 - 2020/09
Concluded
 Technology valorization and commercialization - Product Development (Outros)
HiSeedTech, Portugal
2019/06/17 - 2019/06/20
Concluded
 COST UNGAP Training School "In vitro tools for evaluating the intraluminal and absorption behavior of advanced drug formulations" (Postgraduate Certificate)
Syddansk Universitet Institut for Fysik Kemi og Farmaci, Denmark
2019/05/21 - 2019/05/24
Concluded
 Course on "In vitro models of biological barriers for health sciences applications" (Outros)
Universidade do Porto Faculdade de Farmácia, Portugal
2019/02 - 2019/02
Concluded
 Basic course on LC-MS (Outros)
Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2018/06 - 2018/06
Concluded
 Course on "Manipulation and analysis of gene expression" (Outros)
Escola de Ciências e Tecnologias da Saúde - Universidade Lusófona de Lisboa, Portugal
 19
2018/01/02
Concluded
 MSc in Biochemistry for Health (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Exploring the potential of natural extracts obtained from winemaking waste streams for cosmetic applications" (THESIS/DISSERTATION)
 18
2016/03 - 2016/06
Concluded
 Post-graduation in Advanced Cosmetology (Pós-Graduação)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 19
2015/07/07
Concluded
 BSc in Medicinal Chemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"The effect of iron chelators in photodynamic therapy with redaporfin" (THESIS/DISSERTATION)
 16
2014/09 - 2015/01
Concluded
 French Language and Culture I (Outros)
Universidade de Coimbra Faculdade de Letras, Portugal
Affiliation

Science

Category
Host institution 		Employer
2019/11/01 - Current Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Biologia Experimental e Tecnológica (iBET), Portugal
2018/02/01 - 2019/10/31 Researcher (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
Projects

Grant

Designation Funders
2019/11 - 2024/07 Adding value to chicory roots: evaluation of anti-inflammatory potential of terpenes for application in Inflammatory Bowel Diseases
SFRH/BD/145551/2019
 Fundação para a Ciência e a Tecnologia
Concluded
2018/08/01 - 2019/10/31 CHIC
Call: H2020-NMBP-2016-2017
Research Fellow
Ongoing
2018/02/01 - 2018/07/31 Privately-funded project - iBET/BuggyPower
Privately-funded project
Research Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal
Concluded
2016/09 - 2017/09 WINESENSE
FP7-PEOPLE-2013-IAPP (612208)
Other
Instituto de Biologia Experimental e Tecnológica, Portugal
Concluded

Contract

Designation Funders
2022/01/01 - 2023/06/30 Recovery of antioxidant compounds from halophyte plants using green technologies: application on food and cosmetic industries.
EXPL/ASP-AGR/1655/2021
Instituto de Biologia Experimental e Tecnológica, Portugal

iNOVA4Health, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference paper
  1. Rodrigues, L.; Gaspar, F.B. ; Rodrigues, T.; Carvalho, A.M. ; Matos, Melanie S.; Alexandre, A.M.R.C. ; Paiva, A.; Matias, A. A.. "Supercritical Fluid Extraction of High Value Lipids from Canned Sardine Waste Streams". Paper presented in 12th International Symposium on Supercritical Fluids, Juan-les-Pins, 2018.
Conference poster
  1. Matos, Melanie S.; Claudia Nunes dos Santos; Ana A. Matias; Ana Teresa Serra. Corresponding author: Matos, Melanie S.. "The Healing Power of Chicory: Anti-inflammatory Effect of Sesquiterpene Lactones on the Intestinal Mucosa". Paper presented in 3rd Food Chemistry Conference: Shaping a Healthy and Sustainable Food Chain through Knowledge, 2023.
  2. João Baixinho; Matos, Melanie S.; Agostinho Alexandre; Fernández, Naiara; C. Nunes dos Santos; Ana A. Matias. "Supercritical CO2 extraction as a tool to isolate potential medicinal sesquiterpenes from chicory taproots by-products". Paper presented in I Bio.Natural Meeting, 2019.
  3. Baixinho, João; Melanie S. Matos; Agostinho Alexandre; Fernández, Naiara; C. Nunes dos Santos; Ana A. Matias. "Supercritical CO2 extraction as a tool to isolate potential medicinal sesquiterpenes from Cichorium intybus L. taproots by-products". Paper presented in I Bio.Natural, Bioactive Natural Products Research Meeting, 2019.
  4. Romero-Díez, R.; Rubio, J.; Matos, Melanie; Matias, Ana A.; Rodríguez-Rojo, S.. "Green grape stems biorefinery: polyphenols and hemicellulose extraction". Paper presented in 2nd Conference on Food Bioactives & Health 2018, 2018.
  5. Rodrigues, L.; Gaspar, F.B. ; Rodrigues, T.; Carvalho, A.M. ; Matos, Melanie S.; Alexandre, A.M.R.C. ; Menezes, R.; Paiva, A.; Matias, A. A.. "Supercritical Fluid Extraction of High Value Lipids from Canned Sardine Waste Streams". Paper presented in 12th International Symposium on Supercritical Fluids, 2018.
  6. Matos, Melanie; Rodrigues, Liliana; Serra, Ana T.; Cocero, M. J.; Matias, Ana A.. "Exploring the potential of natural extracts obtained from winemaking waste streams for cosmetic applications". Paper presented in V Encontro Nacional de Estudantes de Química, 2017.
  7. Matos, Melanie; Helder Tão; Anna Mrozek-Wilczkiewicz; Jaroslaw Polanski; Carlos Serpa. "The effect of iron chelators in Photodynamic Therapy with redaporfin". Paper presented in XXIV Encontro Nacional da Sociedade Portuguesa de Química, 2015.
Journal article
  1. Melanie S. Matos; María Ángeles Ávila-Gálvez; Antonio González-Sarrías; Nuno-Valério Silva; Carolina Lage Crespo; António Jacinto; Ana Teresa Serra; Ana A. Matias; Cláudia Nunes dos Santos. "Unveiling the anti-inflammatory potential of 11ß,13-dihydrolactucin for application in inflammatory bowel disease management". Food & Function (2024): https://doi.org/10.1039/D4FO01446D.
    10.1039/D4FO01446D
  2. Katarina Cankar; Johanna Christina Hakkert; Robert Sevenier; Christina Papastolopoulou; Bert Schipper; João P. Baixinho; Naiara Fernández; et al. "Lactucin Synthase Inactivation Boosts the Accumulation of Anti-inflammatory 8-Deoxylactucin and Its Derivatives in Chicory (Cichorium intybus L.)". Journal of Agricultural and Food Chemistry (2023): https://doi.org/10.1021/acs.jafc.2c08959.
    10.1021/acs.jafc.2c08959
  3. Suvi T. Häkkinen; Marina Sokovic; Liisa Nohynek; Ana Ciric; Marija Ivanov; Dejan Stojkovic; Irina Tsitko; et al. "Chicory Extracts and Sesquiterpene Lactones Show Potent Activity against Bacterial and Fungal Pathogens". Pharmaceuticals (2021): https://doi.org/10.3390/ph14090941.
    10.3390/ph14090941
  4. Melanie S. Matos; José D. Anastácio; Cláudia Nunes dos Santos. "Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation". Pharmaceutics 13 7 (2021): 991-991. https://doi.org/10.3390/pharmaceutics13070991.
    10.3390/pharmaceutics13070991
  5. Matos, Melanie S.; Anastácio, José D.; Allwood, J. William; Carregosa, Diogo; Marques, Daniela; Sungurtas, Julie; McDougall, Gordon J.; et al. "Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory". Nutrients 12 11 (2020): 3547. http://dx.doi.org/10.3390/nu12113547.
    Open access • Published • 10.3390/nu12113547
  6. Matos, Melanie S.; Rut Romero-Díez; Ana Álvarez; M. R. Bronze; Soraya Rodríguez-Rojo; Rafael B. Mato; M. J. Cocero; Ana A. Matias. "Polyphenol-Rich Extracts Obtained from Winemaking Waste Streams as Natural Ingredients with Cosmeceutical Potential". Antioxidants (2019): http://dx.doi.org/10.3390/antiox8090355.
    10.3390/antiox8090355
  7. Romero-Díez, R.; Matos, M.; Rodrigues, L.; Bronze, Maria R.; Rodríguez-Rojo, S.; Cocero, M.J.; Matias, A.A.. "Microwave and ultrasound pre-treatments to enhance anthocyanins extraction from different wine lees". Food Chemistry 272 (2018): 258-266. http://dx.doi.org/10.1016/j.foodchem.2018.08.016.
    Published • 10.1016/j.foodchem.2018.08.016
Thesis / Dissertation
  1. Matos, Melanie. "Exploring the potential of natural extracts obtained from winemaking waste streams for cosmetic applications". Master, Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, 2018.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/09/19 Anti-inflammatory potential of a supercritical fluid extract from chicory on the intestinal mucosa: implications of gut microbiota metabolization 4th International Conference on Food Bioactives and Health
(Prague, Czech Republic)
2021/10/13 Intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory 3rd NMS Symposium on Chronic Diseases and Translational Science
CEDOC (Portugal)
2021/02 Industrial waste streams valorization at iBET: health related bioactives from fisheries and wineries Natural products applications: Health, Cosmetic and Food
2019/04 "Supercritical CO2 extraction as a tool to isolate medicinal sesquiterpenes from chicory taproots by-products" 17th European Meeting on Supercritical Fluids (EMSF)
(Ciudad Real, Spain)
2019/02 "Evaluation of natural extracts from winemaking waste streams for cosmetic applications" 10th International Conference on Skin Ageing & Challenges
Leibniz Research Institute for Environmental Medicine (Porto, Portugal)
2018/09 “Evaluation of cosmetic activity of optimized anthocyanin extracts from different wine lees” 2nd Conference on Food Bioactives & Health
iBET (Lisboa, Portugal)
2017/02 “Recovery of natural ingredients from winemaking residues for cosmetic applications” Jornadas Intercalares das Dissertações Anuais dos Mestrados dos Departamentos de Química e de Ciências da vida 2017 da FCT/UNL
FCT/UNL (Lisboa, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/02 - Current Participation in the 10th International Conference on Skin Ageing & Challenges and oral presentation
Conference
 10th International Conference on Skin Ageing & Challenges
Leibniz-Institut für umweltmedizinische Forschung an der Heinrich-Heine-Universität Düsseldorf gGmbH, Germany
2018/09 - Current Participation in the 2nd Conference on Food Bioactives & Health and oral presentation
Conference
 2nd Conference on Food Bioactives & Health
Intituto de Biologia Experimental e Tecnológica (iBET), Portugal
2019/02 - 2019/02 Participation in the UNGAP COST action Spring Meeting
Meeting
 COST UNGAP Spring Meeting
European Cooperation in Science and Technology, Belgium
2017/04 - 2017/04 Participation in the V National Meeting of Chemistry Students and poster presentation
Meeting
 V Encontro Nacional de Estudantes de Química (V ENEQUI)
Universidade de Coimbra, Portugal
2017 - 2017 Participation in the WineSense project Summer School: Potenciales Aplicaciones Comerciales del Extracto de Uva
Workshop
 Potenciales Aplicaciones Comerciales del Extracto de Uva
Bodega Emina, Spain
2015 - 2015 Participation in the III National Meeting of Chemistry Students
Meeting
 III Encontro Nacional de Estudantes de Química (III ENEQUI)
Universidade de Aveiro, Portugal
2015 - 2015 Participation in the XXIV National Meeting of the Portuguese Society of Chemistry and poster presentation
Conference
 XXIV Encontro Nacional da Sociedade Portuguesa de Química
Sociedade Portuguesa de Química, Portugal
2014 - 2014 Participation in the II National Meeting of Chemistry Students
Meeting
 II Encontro Nacional de Estudantes de Química (II ENEQUI)
Universidade da Beira Interior, Portugal
2013 - 2013 Participation in the I National Meeting of Chemistry Students
Meeting
 I Encontro Nacional de Estudantes de Química (I ENEQUI)

Association member

Society Organization name Role
2013 - 2015 Núcleo de Estudantes de Química da Associação Académica de Coimbra (NEQ/AAC) Organization of activities and events within the scope of Professional Careers in Chemistry and related sciences

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/01 - 2023/01 Participation in External Evaluation Committee for accreditation of Higher Education Study Programs
Evaluator
 Agência de Avaliação e Acreditação do Ensino Superior (A3ES), Portugal Agência de Avaliação e Acreditação do Ensino Superior (A3ES)

Mentoring / Tutoring

Topic Student name
2020/01/13 - 2020/01/17 Cell-based assays: Cytotoxicity and Antiproliferative potential of synthetic compounds Beatriz Torgal Martins
Distinctions

Award

2023 Best Poster Award
2019 Best Poster Award