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João Pedro Ferreira da Costa Novo. Completed the Mestrado in Mestrado em Investigação Biomédica in 2019/09/27 by Universidade de Coimbra Faculdade de Medicina and Licenciatura in Licenciatura em Ciências Biomédicas in 2017/06/23 by Universidade de Aveiro Departamento de Ciências Médicas. Attends the Doutoramento in Biologia Experimental e Biomedicina by Universidade de Coimbra Instituto de Investigação Interdisciplinar since 2021/12/01. Published 4 articles in journals. Has 1 section(s) of books. Organized 3 event(s). Participated in 9 event(s). Has received 3 awards and/or honors. Participates and/or participated as Other in 1 project(s), PhD Student Fellow in 1 project(s), Research Fellow in 3 project(s) and Researcher in 1 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Neurosciences, Medical and Health Sciences, Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology and Natural sciences with emphasis on Biological Sciences with emphasis on Molecular Biology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Metilfenidato; Microglia; Células Endoteliais; Neuroinflamação; Stress Oxidativo; Methylphenidate; Endothelial cells; Neuroinflammation; Oxidative Stress; Methylmercury; Mercury cycle; Neurotoxicity; Neurons; Oligodendrocytes; Astrocytes; Apoptosis; Necrosis; Cognition; Synaptic function; Neurogenesis; Aging; Ageing; Senescence; Blood-brain barrier; Nanoparticles; Neurosciences; Vision Sciences; Senolytics; Brain; Science; Science communication; Bone regeneration; Innovation; Health; Entrepreneurship; Career; Mental Health; Science Funding; Clinical Trials; Nerve Regeneration; Spinal Cord; Hippocampus; Inflammatory mediators; neurodegeneration; Brain endothelial cells; .
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Identification

Personal identification

Full name
João Pedro Ferreira da Costa Novo

Citation names

  • Novo, João Pedro

Author identifiers

Ciência ID
6A14-AF6E-0374
ORCID iD
0000-0001-8015-2685

Email addresses

  • jpfcnovo@gmail.com (Professional)
  • jnovo@cnc.uc.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2021/12/01 - 2025/11/30
Ongoing
 Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022/05/16 - 2022/05/26
Concluded
 Connecting Researchers with the Society and Industry (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/11/09 - 2020/11/20
Concluded
 IV Modular Training in Laboratory Animal Course - Function A (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 14,85
2017/09 - 2019/09/27
Concluded
 Mestrado em Investigação Biomédica (Mestrado)
Major in Neurobiologia
Universidade de Coimbra Faculdade de Medicina, Portugal
"Effect of methylphenidate on microglia: tracking direct and brain endothelial cells-mediated changes" (THESIS/DISSERTATION)
 18,3
2014/09 - 2017/06/23
Concluded
 Licenciatura em Ciências Biomédicas (Licenciatura)
Major in Molecular Biomedicine
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
 16,2
Affiliation

Science

Category
Host institution 		Employer
2021/06/01 - 2021/11/30 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/01/15 - 2021/04/14 Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2020/01/01 - 2020/12/31 Researcher (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
Projects

Contract

Designation Funders
2021/06/01 - Current A therapeutic strategy to fight blood-brain-barrier (BBB) ageing
PTDC/BTM-SAL/5174/2020
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - Current Reset Ageing
952266
PhD Student Fellow
Universidade de Coimbra, Portugal

Newcastle University, United Kingdom

Universiteit Maastricht, Netherlands

Leibniz Institut für Altersforschung - Fritz-Lipmann Institut eV, Germany
European Comission
Ongoing
2021/01/15 - 2021/04/14 Enhancing Research in Ageing (ERA@UC)
Grant agreement ID: 669088
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra
Concluded
2020/01/01 - 2020/12/31 HealthyAging 2020
Centro 2020 000012 Healthy Aging 2020
Research Fellow
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2020/12/31 MercuMemory: Methylmercury neurotoxicity in adult brain neurogenic niches: chronic neurogeneration and cognitive decline.
POCI-01-0145-FEDER-031699
Researcher
Faculdade de Medicina da Universidade de Coimbra, Portugal
Concluded
2018/05 - 2019/07 BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Aluno de mestrado
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. João O. Malva; Beatriz Martins; Ricardo Moreira; Novo, João Pedro; Frederico C. Pereira; Ramon Raposo; Reinaldo oriá; Fontes Ribeiro CA. "Neuroinflammation in the elderly". In Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging, edited by Colin Martin; Victor Preedy; Rajkumar Rajendram, 139-148. Londres, United Kingdom: Academic Press - Elsevier, 2021.
    Published
Conference abstract
  1. Fonseca, Élisa; Novo, João Pedro; Corte Real Martins, Beatriz; Raposo, Ramon; Pereira, Frederico; Oriá, Reinaldo B.; Fontes Ribeiro C; João O. Malva. "Necrotic-like BV-2 Microglial cell death induced by acute exposure to Methylmercury". Paper presented in FENS Forum 2022, Paris, 2022.
    Submitted
  2. Fonseca, Élisa; Novo, João Pedro; Corte Real Martins, Beatriz; Raposo, Ramon; Sardão, Vilma; Oliveira, Paulo; Pereira, Frederico; et al. "BV-2 Microglial cell death induced by acute exposure to Methylmercury". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI 2022), Bari, 2022.
    Submitted
Conference poster
  1. Novo, João Pedro; Caetano, Carolina; Susana Carvalho Rosa; Thomas von Zglinicki; Ferreira, Lino. "Development of an in vitro human blood-brain barrier model with ageing properties". Paper presented in 3rd RESETageing Conference, 2023.
  2. Novo, João Pedro; Caetano, Carolina; L. Gee; Moreira, Irina S; Diana Jurk; Rosa, Susana; Ferreira, Lino. "The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program". Paper presented in Annual Meeting of the European Tissue Repair Society (ETRS) and the Portuguese Society of Stem Cells and Cell Therapies (SPCE-TC), 2023.
  3. Novo, João Pedro; Caetano, Carolina; L. Gee; Moreira, Irina S; Diana Jurk; Rosa, Susana; Ferreira, Lino. "The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program". Paper presented in Annual Meeting of the German Association for Aging Research (DGfA), 2023.
  4. Novo, João Pedro; Caetano, Carolina; L. Gee; Moreira, Irina S; Diana Jurk; Rosa, Susana; Ferreira, Lino. "The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program". Paper presented in 2nd RESETageing Conference - Biology of Ageing: Senescence and Cell Stress, 2022.
  5. Novo, João Pedro; Caetano, Carolina; L. Gee; Moreira, Irina S; Diana Jurk; Rosa, Susana; Ferreira, Lino. "The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program". Paper presented in 1st MIA Portugal Spring School on Aging, 2022.
  6. Novo, João Pedro; Caetano, Carolina; L. Gee; Moreira, Irina S; Diana Jurk; Rosa, Susana; Ferreira, Lino. "The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2022.
  7. João P. Novo; Carolina Caetano; Rosa, Susana; Ferreira, Lino. "An in vitro human senescent blood-brain barrier model". Paper presented in BEB Day 2022 - The overview effect, 2022.
  8. Élisa Fonseca; Novo, João Pedro; Corte Real Martins, Beatriz; Raposo, Ramon; Frederico C. Pereira; Reinaldo B. Oriá; Carlos Fontes-Ribeiro; João O. Malva. "Neurotoxicity and molecular effects of acute Methylmercury exposure in Microglial Cells". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  9. Élisa Fonseca; Novo, João Pedro; Corte Real Martins, Beatriz; Raposo, Ramon; Frederico C. Pereira; Reinaldo B. Oriá; Fontes Ribeiro C; João O. Malva. "Acute Methylmercury exposure induces Neurotoxicity and Microglial Cell Death". Paper presented in V Symposium Portuguese Glial Network 2021, 2021.
  10. Novo, João Pedro; Beatriz Martins; Ramon Raposo; Frederico C. Pereira; Reinaldo Oriá; João O. Malva; Fontes Ribeiro CA. "The Effect Of Methylmercury On Microglia Inflammatory Responses". Paper presented in SPF Meeting 2021, 2021.
  11. Beatriz Martins; Novo, João Pedro; Ricardo Moreira; Ramon Raposo; Frederico C. Pereira; Reinaldo Oriá; João O. Malva; Fontes Ribeiro CA. "The Impact Of Methylmercury On Microglia-Derived Neuroinflammation And Neurogenesis". Paper presented in I International CAPES Print Symposium in Neurosciences and III Simpósio Luso-Brasileiro de Neurociências, 2020.
  12. Novo, João Pedro; Santos, Liliana; Leitão, Ricardo Alexandre; Fontes Ribeiro CA; Rosa Cristina Simões Fernandes; Ana Paula Pereira da Silva Martins. "Effect of methylphenidate on microglia: an in vitro study". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences,, 2019.
  13. Beatriz Martins; Novo, João Pedro; João O. Malva; Fontes Ribeiro CA; Ana Paula Pereira da Silva Martins; Frederico Pereira; Reinaldo oriá. "Mercumemory: the effect of methylmercury exposure in microglia-mediated neuroinflammation". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
  14. Beatriz Martins; Novo, João Pedro; Ana Paula Pereira da Silva Martins; Frederico Pereira; Reinaldo oriá; Fontes Ribeiro CA; João O. Malva. "Unraveling the effect of methylmercury exposure in neuroinflammation and neurogenesis". Paper presented in Sociedade Portuguesa de Neurociências Meeting, 2019.
Journal article
  1. Novo, João Pedro; Gee, Lucy; Caetano, Carolina A.; Tomé, Inês; Vilaça, Andreia; von Zglinicki, Thomas; Moreira, Irina S.; et al. "Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence". Aging Cell (2024): http://dx.doi.org/10.1111/acel.14270.
    Open access • 10.1111/acel.14270
  2. Novo, João Pedro; Muga, Mariana; Lourenço, Teresa; Sanches, Eliane S; Leitão, Ricardo A.; Silva, Ana Paula. "Dichotomous effect of methylphenidate on microglia and astrocytes: Insights from in vitro and animal studies". Toxicology Letters 389 (2023): http://dx.doi.org/10.1016/j.toxlet.2023.10.008.
    Open access • 10.1016/j.toxlet.2023.10.008
  3. Martins, B.; Novo, João Pedro; Fonseca, É.; Raposo, R.; Sardão, V. A.; Pereira, F.; Oriá, R. B.; Fontes-Ribeiro, C.; Malva, J.. "Necrotic-like BV-2 microglial cell death due to methylmercury exposure". Frontiers in Pharmacology 13 (2022): http://dx.doi.org/10.3389/fphar.2022.1003663.
    Published • 10.3389/fphar.2022.1003663
  4. Novo, João Pedro; Martins, Beatriz; Raposo, Ramon S.; Pereira, Frederico C.; Oriá, Reinaldo B.; Malva, João O.; Fontes-Ribeiro, Carlos. Corresponding author: Malva, João O.. "Cellular and Molecular Mechanisms Mediating Methylmercury Neurotoxicity and Neuroinflammation". International Journal of Molecular Sciences 22 6 (2021): 3101. http://dx.doi.org/10.3390/ijms22063101.
    Open access • Published • 10.3390/ijms22063101
Thesis / Dissertation
  1. Novo, João Pedro Ferreira da Costa. "Effect of methylphenidate on microglia: tracking direct and brain endothelial cells-mediated changes". Master, Universidade de Coimbra Faculdade de Medicina, 2019. http://hdl.handle.net/10316/89656.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/05/29 Brain endothelial senescence mediates blood-brain barrier dysfunction upon ageing: development of an in vitro BBB model MIA-Portugal Ageing Spring School 2024
MIA-Portugal (Coimbra, Portugal)
2024/03/18 The transition from a young to aged BBB is mediated by a senescence brain endothelial cell program Young ICSA Symposium
Young International Cell Senescence Association (ICSA) (Oxford, United Kingdom)
2022/12/06 The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program Ageing without Borders
Ageing without Borders - Algarve Biomedical Center Research Institute (Faro, Portugal)
2022/09/17 The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program 2nd RESETageing Conference: Biology of Ageing: Senescence and Cell Stress
ResetAgeing - Newcastle University (Newcastle, United Kingdom)
2022/06/03 Senescent brain endothelial cell program partially mediates the transition from young to aged Blood-Brain Barrier I International Meeting on the Brain Vasculature
NOVA Medical School (Portugal)
2022/04/06 The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program 1st MIA Portugal Spring School on Aging
Multidisciplinary Institute of Ageing (MIA) Portugal (Coimbra, Portugal)
2020/07/08 Mercury toxicity in neuroinflammation and neurogenesis CIBB Neuroscience and Disease 2020 Online Retreat
CIBB - Center for Innovative Biomedicine and Biotechnology (Coimbra, Portugal)
2019/05/10 Neurovascular alterations induced by methylphenidate: ADHD versus control 1st CIBB Neuroscience and Disease Retreat
CIBB - Center for Innovative Biomedicine and Biotechnology (Miranda do Corvo, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/09/01 - 2023/02/08 The 17th edition of the PDBEB symposium organized by the Doctoral Programme in Experimental Biology and Biomedicine students, from the Institute of Interdisciplinary Research, University of Coimbra, took place on the 7th and 8th of February 2023. Under the theme "Science Challenges: This Fight of Ours!", this edition gathered a multidisciplinary panel to address current issues that affect the scientific community with a special focus on science financing, clinical trials, mental health, and science communication. https://www.cnc.uc.pt/en/pdbeb/beb (2023/02/07 - 2023/02/08)
Symposium (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/07/09 - 2022/07/09 PicNic with Health (PicNiC com Saúde) was promoted by the Institute of Clinical and Biomedical Research of Coimbra and the Faculty of Medicine of the University of Coimbra. With an informal character and designed for all ages, PicNic with Health aimsed to lead people to adopt healthier habits. (2022/07/09 - 2022/07/09)
Exhibition (Other)
 Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2022/05/20 - 2022/05/20 Brain Fair organized by CNC UC, took place in the Botanical Garden of the University of Coimbra. This event was an initiative within the scope of the Brain Awareness Week and was focused on science communication and public engagement. (2022/05/20 - 2022/05/20)
Exhibition (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/05/26 - Current PhD project presentation for high school students on the scope of the Advanced Course "Connecting Researchers with the Society and Industry"
Other
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023/09/29 - 2023/09/29 The European Researchers' Night (NEI) was a Science Communication event that took place in downtown Coimbra, with the aim of promoting awareness and the population's involvement in science, bringing researchers and civil society closer together. Researchers showed their Science, in the most varied scientific areas, approaching the citizens of Coimbra and the whole community, promoting scientific literacy. NEI took place simultaneously in several cities in Europe.
Exhibition
 2023 European Researcher's Night
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/11/07 - 2022/11/11 i-Days promote health innovation among university students through dozens of one-day and two-day programmes held in academic institutions around Europe. Students from all academic areas receive an introduction to practical health innovation tools and compete in teams to tackle real-life health challenges posed by EIT Health, local organisations, private corporations or start-ups.
Workshop
 Cantanhede Innovation Days 2022
European Institute of Innovation & Technology (EIT) Health, Hungary
2022/10/11 - 2022/10/11 The second edition of FIC.A - International Science Festival took place between the 10th and 16th of October, in , Hub-ACT (Art, Science & Technology), a future incubation center for creative industries, in Porto Salvo, Oeiras, Portugal. During 7 days, the Festival aimed to inspire and capture the attention of children and adults, create new audiences for science and use the arts to communicate exciting science and technology. The mission was to inspire visitors of all ages with the amazing science, engineering and technology we find all around us.
Exhibition
 FICA - Festival Internacional de Ciência
Câmara Municipal de Oeiras, Portugal
2022/09/30 - 2022/09/30 The European Researchers' Night (NEI) was a Science Communication event that took place in downtown Coimbra. Researchers showed their Science, in the most varied scientific areas, approaching the citizens of Coimbra and the whole community, promoting scientific literacy. NEI took place simultaneously in several cities in Europe.
Exhibition
 2022 European Researcher's Night
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/09/16 - 2022/09/17 The 2nd RESETageing Conference - Biology of Ageing: Sconference is organized in Newcastle for 2 days. The event is supported by the European project RESETageing that has been funded by the H2020 Widespread Twinning program. Ageing is a triumph of the contemporary society but also represents a great challenge for the coming generations. The conference chaired by Satomi Miwa, Thomas von Zglinicki, Viktor Korolchuk and Luís Estronca aims to show us recent progresses in the ageing biology covering aspects as cellular senescence and cellular stress.
Conference
 2nd RESETageing Conference - Biology of Ageing: Senescence and Cell Stress
Newcastle University, United Kingdom
2022/09/12 - 2022/09/15 Training School - Single cell techniques in senescence and ageing. Delivered in collaboration with the Flow Cytometry Core Facility of Newcastle University
Workshop
 Training School - Single cell techniques in senescence and ageing
Newcastle University, United Kingdom
2021/09/24 - 2021/09/24 The European Researchers' Night is a Europe-wide public event, that displays the diversity and impact of science on citizens' daily lives in inspiring ways. The yearly theme in Portugal was aligned with the European Ecological Pact, which proposes that the neutral impact on the climate by 2050, through the promotion of initiatives that protect the environment and boost the green economy. The activities included the promotion of beneficial habits for the environment and the communication the communication of research carried out by the laboratory.
Exhibition
 2021 European Researchers' Night
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2018 The European Researchers' Night is a Europe-wide public event, that displays the diversity and impact of science on citizens' daily lives in inspiring ways. Research centers at the University of Coimbra promote activities to disseminate science to different audiences.
Exhibition
 2018 European Researchers' Night
Universidade de Coimbra Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2022/07 - 2022/12 Cartas com Ciência - Letters with Science Scientist

Journal scientific committee

Journal title (ISSN) Publisher
2022/10/18 - Current Food Science and Nutrition (2048-7177) Wiley Periodicals, LLC.
Distinctions

Award

2022 Best short communication - I International Meeting on the Brain Vasculature
Nova Medical School, Portugal

Sociedade Portuguesa de Neurociências, Portugal

Concessus, Portugal
2021 2021 FCT PhD Studentship
Fundação para a Ciência e a Tecnologia, Portugal

Title

2022 CIBB PhD Students Representative