Pasqualino De Luca (6A18-29F1-5AEC)

Curriculum Vitae

Pasqualino De Luca

Pasqualino De Luca holds a Master's degree in Cellular and Molecular Biology, conferred by the University of Coimbra in September 2016, and a Master's degree in Biology from the University of Sannio, Italy, obtained in March 2017. He also earned a Bachelor's degree in Biological Science from the University of Sannio in October 2014. Recently, he successfully defended his PhD dissertation on December 12, 2024. Throughout his academic journey, Pasqualino has authored and published four articles in reputable scientific journals. His expertise lies in the fields of molecular and cellular biology, with a particular focus on Neuroscience. His curriculum Vitae highlights his proficiency in areas such as glutamate receptors, BDNF, and synaptic plasticity, reflecting his dedication to advancing scientific knowledge in these domains.

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Identification

Personal identification

Full name: Pasqualino De Luca

Citation names

De Luca, Pasqualino

Author identifiers

Ciência ID: 6A18-29F1-5AEC
ORCID iD: 0000-0002-1113-2135

Addresses

Center for Neuroscience and Cell Biology. University of Coimbra Rua Larga Faculty of Medicine, Pólo I, 1st floor, 3004-504, Coimbra, Coimbra, Portugal (Professional)
Rua do Alecrim, 8, 1C, 3045-113, Coimbra, Coimbra, Portugal (Personal)

Websites

http://www.cnbc.pt/research/department_group_show.asp?iddep=1107&idgrp=1110 (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Italian	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Advanced (C1)
Portuguese	Advanced (C1)	Advanced (C1)	Intermediate (B1)	Advanced (C1)

Education

	Degree	Classification
2017/12/01 - 2022/12/12 Concluded	PhD programme in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal "DIFFERENTIAL REGULATION OF GLUN2A- AND GLUN2B-CONTAINING NMDA RECEPTORS BY BDNF IN THE PLASTICITY OF HIPPOCAMPAL SYNAPSES" (THESIS/DISSERTATION)
2017/03/14 Concluded	Biology (Laurea) Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Italy "Regulation of synaptic transmission by BDNF: effects on NMDA receptor-mediated mEPSCs" (THESIS/DISSERTATION)	110 with honors
2016/09/09 Concluded	Cellular and Molecular Biology (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Regulation of synaptic transmission by BDNF: Effects on NMDA receptor-mediated mEPSCs" (THESIS/DISSERTATION)	19/20
2014/10 Concluded	Biological Science (Bachelor) Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Italy "Canali per l’acqua nel sistema nervoso centrale: aspetti fisiopatologici" (THESIS/DISSERTATION)	103/110

Affiliation

Science

	Category Host institution	Employer
2023/07/06 - Current	Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

	Category Host institution	Employer
2017/12/01 - 2021/12/01	PhD student	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Projects

Grant

	Designation	Funders
2018/06/01 - 2021/05	BDNF-induced alterations in the synaptic proteome and neuronal excitability in the pilocarpine model of temporal lobel epilepsy POCI-01-0145-FEDER-028656 PhD Student Fellow	Ongoing

Contract

	Designation	Funders
2022/02/01 - 2022/05/31	Synaptic alterations in the pilocarpine model of temporal labe epilepsy: inter-and intracellular signalling mechanisms COVID/BD/152508/2022 Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/01 - 2022/03/31	BDNF-induced alterations in the synaptic proteome and neuronal excitability in the pilocarpine model of temporal lobel epilepsy PTDC/MED-NEU/28656/2017 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/06/01 - 2022/03/31	Targeting the K+-Cl- cotransporter KCC2 to maintain GABAergic neurotransmission: a novel therapeutic strategy for epilepsy PTDC/MED-FAR/30659/2017 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017/12/01 - 2022/01/31	Synaptic alterations in the pilocarpine model of temporal labe epilepsy: inter-and intracellular signalling mechanisms PD/BD/135498/2018 Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Conference poster	De Luca, Pasqualino; Diana Adão; Pedro Perdigão; Pereira de Almeida, Luis ; Magda M Santana. "Neuronal maturation of induced pluripotent stem cell is altered in Machado Joseph-Disease cell lines". Paper presented in ETRS & SPCE-TC joint meeting 2023, 2023. De Luca, Pasqualino (6A18-29F1-5AEC); Pedro Afonso. "BDNF upregulates synaptic expression of GluN2B-containing NMDAR by a translation-dependent mechanism in cultured hippocampal neuron". Paper presented in XVII Meeting of the Italian Society for Neuroscience, 2017. De Luca, Pasqualino (6A18-29F1-5AEC); Pedro Afonso. "BDNF upregulates synaptic expression of GluN2B-NMDAR in cultured hippocampal neurons". Paper presented in 7th ISN Special Neurochemistry Conference on SYNAPTIC FUNCTION AND DYSFUNCTION IN BRAIN DISEASES, 2016.
Journal article	Mele, Miranda; De Luca, Pasqualino; Santos, Ana Rita; Vieira, Marta; Salazar, Ivan L.; Pinheiro, Paulo S.; Duarte, Carlos B.. "GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons". The FASEB Journal 35 8 (2021): http://dx.doi.org/10.1096/fj.201903061rr. Published • 10.1096/fj.201903061rr Mele, Miranda; Vieira, Ricardo; Correia, Bárbara; De Luca, Pasqualino; Duarte, Filipe V.; Pinheiro, Paulo S.; Duarte, Carlos B.. "Transient incubation of cultured hippocampal neurons in the absence of magnesium induces rhythmic and synchronized epileptiform-like activity". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-90486-y. 10.1038/s41598-021-90486-y Pedro Afonso; Pasqualino De Luca; Rafael S. Carvalho; Luísa Cortes; Paulo Pinheiro; Barbara Oliveiros; Ramiro D. Almeida; Miranda Mele; Carlos B. Duarte. "BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons". Science Signaling 12 586 (2019): eaav3577-eaav3577. https://doi.org/10.1126/scisignal.aav3577. 10.1126/scisignal.aav3577 Graciano Leal; Diogo Comprido; Pasqualino de Luca; Eduardo Morais; Luís Rodrigues; Miranda Mele; Ana R. Santos; et al. "The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons". eneuro 4 6 (2017): ENEURO.0268-17.2017. https://doi.org/10.1523/ENEURO.0268-17.2017. 10.1523/ENEURO.0268-17.2017 Leal, Graciano; Comprido, Diogo; Luca, Pasqualino de; Morais, Eduardo; Rodrigues, Luís; Mele, Miranda; Santos, Ana R.; et al. "The RNA-binding protein hnRNP K mediates the effect of BDNF on dendritic mRNA metabolism and regulates synaptic NMDA receptors in hippocampal neurons". (2017): http://hdl.handle.net/10773/27865. 10.1523/ENEURO.0268-17.2017
Thesis / Dissertation	Luca, Pasqualino De. "Regulation of synaptic transmission by BDNF : effects on NMDA receptor-mediated mEPSCs". Master, 2016. http://hdl.handle.net/10316/44084.