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Sílvia de Vasconcelos Chaves concluiu o Doutoramento em Química em 1998 pela Universidade de Lisboa, Instituto Superior Técnico, tendo completado a Licenciatura em Engenharia Química em 1988 pela Universidade de Lisboa, Instituto Superior Técnico. Co-orientou 2 tese(s) de doutoramento, orientou 1 dissertação de mestrado e co-orientou 7 dissertação(ões) de mestrado. Desde 2005 que colabora em diversas actividades de divulgação científica da Química em eventos organizados pelo Departamento de Engenharia Química do Instituto Superior Técnico.
Identification

Personal identification

Full name
Sílvia de Vasconcelos Chaves

Author identifiers

Ciência ID
6A1B-AE7B-087F
ORCID iD
0000-0002-8554-4992
Researcher Id
F-9097-2014

Email addresses

  • silvia.chaves@tecnico.ulisboa.pt (Professional)

Addresses

  • Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, 1, 1049-001, Lisboa, Lisboa, Portugal (Professional)
Projects

Contract

Designation Funders
2013/06/01 - 2016/12/31 De pequenas moléculas bioactivas a uma abordagem ÓMICA integrada: Ferramentas de Espectrometria de Massa para a compreensão mecanística de propriedades farmacológicas e funcionais, toxicidade e respostas ao stress
RECI/QEQ-MED/0330/2012
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Centro Hospitalar de Lisboa Central EPE, Portugal

Hospital Professor Doutor Fernando Fonseca EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/12/01 - 2012/11/30 Novas matrizes sólidas quelantes com hidroxipirimidinonas imobilizadas para aplicações ambientais e biológicas
PTDC/QUI/65647/2006
Researcher
Universidade de Aveiro, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Laboratório Nacional de Energia e Geologia - Campus do Lumiar, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2006/10/01 - 2010/09/29 Novo Tipo de Compostos Orientados para Receptores Biológicos com Potenciais Aplicações Farmacológicas
PDCT/QUI/56985/2004
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2006 - 2008 Chemistry discovers the child
Projecto Ciência Viva VI Nº 976
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Ciência Viva
Concluded
2006 - 2007 Synthesis and metal binding ability of new chelating agents for potential medical application
Hungarian- Portuguese Intergovernmental S&T Cooperation Programme for 2006-2007
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal
Concluded
2004 - 2005 Some factors affecting the selectivity of siderophores and models for metal ions
Hungarian- Portuguese Intergovernmental S&T Cooperation Programme for 2004-2005
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal
Concluded
2002 - 2005 Functionalization of solid supports with hydroxypyrimidone type chelators for environmental applications
POCTI/38094/QUI/2001
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal

Laboratório Nacional de Energia e Geologia - Campus do Lumiar, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2001 - 2005 Biomimetic studies of metalloenzymes: function and Inhibition of model hydrolases and related systems
COST-D21
Researcher
University College Dublin College of Science, Ireland

Universidade de Lisboa Centro de Química Estrutural, Portugal
Concluded
2000 - 2004 Reconhecimento Molecular e Sequestração de Iões Metálicos com Vista a Potenciais Aplicações Biomédicas
POCTI/35344/QUI/2000
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2002 - 2003 Interaction Between Metal Ions and Siderophore Models in Aqueous Solution
Hungarian- Portuguese Intergovernmental S&T Cooperation Programme for 2002-2003
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal
Concluded
2000 - 2001 Interaction Between Biologically active Hydroxamic acids and Different Metal Ions
Hungarian- Portuguese Intergovernmental S&T Cooperation Programme for 2000-2001
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal
Concluded
1998 - 2001 Critical Evaluation of Stability Constants and Thermodynamic Functions of Metal Complexes of Crown-Ethers
Oficial IUPAC Project Nº 560/40/97
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal

Centre International de Recherche aux Frontières de la Chimie, France

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
International Union of Pure and Applied Chemistry
Concluded
1998 - 2001 Critical Evaluation of Stability Constants and Thermodynamic Functions of Metal Complexes of Crown-Ethers
Oficial IUPAC Project Nº 560/40/97
 International Union of Pure and Applied Chemistry
Outputs

Publications

Book
  1. Luca Piemontese; Fulvio Loiodice; Chaves, Sílvia; M. Amélia Santos. Frontiers in Clinical Drug Research - Alzheimer Disorders: Volume 8. BENTHAM SCIENCE PUBLISHERS. 2019.
    Published • 10.2174/97898114018931190801
Book chapter
  1. Chaves, Sílvia; Piemontese, Luca; Fulvio Loiodice; M. Amélia Santos. "The Therapy of Alzheimer´s Disease: Towards a New Generation of Drugs". In Frontiers in Clinical Drug Research – Alzheimer Disorders, 33-80. Bentham, 2019.
    Published
  2. Chaves, Sílvia; Sónia Canário; Marta Carrasco; Lurdes Mira; M. Amélia Santos. "Anti-oxidant activity of hydroxy(thio)pyrone iron-chelators". In Metal Ions in Biology and Medicine 2008, edited by John Libbey Eurotext, 887-892. John Libbey Eurotext, 2008.
    Published
  3. Chaves, Sílvia; Marco Gil; Ratomir Jelic; M. Amélia Santos. "Iminodiacetyl-monohydroxamate derivatives as potent and selective MMP inhibitors". In Metal Ions in Biology and Medicine 2006, edited by John Libbey Eurotext, 117-121. John Libbey Eurotext, 2006.
    Published
  4. M. Alexandra Esteves; Anabela Cachudo; Cláudia Ribeiro; Chaves, Sílvia; Armando Rossello; M. Amélia Santos; Esteves, M. Alexandra; Anabela Cachudo; Santos, M. Amélia. "New Hydroxypyrimidinones as Inhibitors of Matrix Metalloproteinases". In Metal Ions in Biology and Medicine 2006, edited by John Libbey Eurotext, 35-39. John Libbey Eurotext, 2006.
    Published
  5. M. Amélia Santos; Marco Gil; Sérgio Marques; M. Lurdes Gano; Chaves, Sílvia. "Complexation of Three N-Carboxyalkyl Derivatives of 3-Hydroxy-4-Pyridinones with Fe(III), Al(III), Ga(III) and In(III). Studies in vitro and in vivo". In Metal Ions in Biology and Medicine 2002, 655-658. John Libbey Eurotext, 2002.
    Published
Conference paper
  1. M. Alexandra Esteves; Anabela Cachudo; Chaves, Sílvia; M. Amélia Santos. "Metal-Sequestering Properties of New Solid Matrices Functionalized with Hydroxypyrimidinones". Paper presented in 7th International Symposium on Chelating Agents in Biomedicine, Toxicology and Therapeutics, ISCABTT 7, 2004.
    Published • 10.1063/1.4980820
  2. M. Amélia Santos; Sérgio Marques; Marco Gil; Chaves, Sílvia. "N-Benzyl-iminodiacetohydroxamate and Carboxymethylhydroxamate Ligands. Synthesis and Complexation Studies with Cu(II), Ni(II) and Zn(II)". Paper presented in 10th International Conference on Bioinorganic Chemistry, Florence, 2001.
    Published
Conference poster
  1. Chaves, Sílvia; Inês Dias; Léo Bon; Angelika Banas; M. Amélia Santos. "Rivastigmine-Indole hybrids as a new family of multitarget metal-modulating anti-Alzheimer´s Disease agents: Cu(II) and Fe(III) chelation studies". 2023.
  2. Chaves, Sílvia; Angelika Banas; Léo Bon; Inês Dias; M. Amélia Santos. "Rivastigmine-Indole hybrids as multitarget compounds for potential treatment of Alzheimer´s Disease". 2023.
  3. Chaves, Sílvia; Vicente-Zurdo, David; Noelia Rosales-Conrado; María Eugenia León-González; M. Amélia Santos; Yolanda Madrid. "Novel BIM-RIV hybrids as promising multitarget compounds for the potential treatment of Alzheimer´s disease". 2022.
  4. Chaves, Sílvia; Rosalba Leuci; Poliseno Viviana; Michele Solfrizzo; M. Amélia Santos; Antonio Laghezza; Marco Catto; et al. "Natural-inspired structures for the multi-target treatment of Alzheimer´s disease: a successful approach for drug design". 2022.
  5. Chaves, Sílvia; Vicente-Zurdo, David; Leonardo Brunetti; Luca Piemontese; Yolanda Madrid; M. Amélia Santos. "Novel Rivastigmine-based Multitarget Hybrids for Potential Treatment of Alzheimer’s Disease: Cu(II) and Fe(III) chelation studies". 2022.
  6. Chaves, Sílvia; Beatrice Bargagna; Lidia Ciccone; Susanna Nencetti; M. Amélia Santos; Caterina Camodeca; Orlandini, Elisabetta. "Ferulic acid derivatives as metal modulating agents with potential anti-Alzheimer´s disease roles". 2021.
  7. Marina Costa; Romane Josselin; Diana Silva; Susana M. Cardoso; Chaves, Sílvia; M. Amélia Santos. "Donepezil based multi-target hybrids as metal chelating agents for potential Alzheimer´s disease therapy". Paper presented in International Symposium on Metal Complexes ISMEC 2019, 2019.
  8. M. Amélia Santos; Marina Costa; Federica Rinaldo; Romane Josselin; Luca Piemontese; Vito Capriati; Diana Silva; Sandra M. Cardoso; Chaves, Sílvia. "New donepezil mimetic hybrids towards distint Alzheimer´s disease targets: amyloyd-ß, metal-Aß and cholinesterase". Paper presented in 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders (AD/PD 2019), 2019.
  9. M. Amélia Santos; Gaia Fancellu; Karam Chand; Luca Piemontese; Diana Silva; Sandra M. Cardoso; Chaves, Sílvia. "Exploiting tacrine-benzofuran hybrids as multi-target directed ligands for Alzheimer´s disease therapy". Paper presented in 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders (AD/PD 2019), 2019.
  10. G. Fancellu; Karam Chand; Daniel Tomás; Luca Piemontese; Chaves, Sílvia; M. Amélia Santos. "Exploiting tacrine-based hybrids as a multi-target strategy for potential anti-Alzheimer´s drugs". Paper presented in 12º Encontro Nacional de Química Orgânica e 5º Encontro de Química Terapêutica (12ENQO/SENQT), 2018.
  11. Luca Piemontese; Daniel Tomás; Asha Hiremathad; M. Catto; A. Laghezza«; Chaves, Sílvia; F.M. Perna; et al. "Metal chelators for the multi-target therapy of Alzheimer´s Disease: isolation/synthesis and preliminary biological evaluation of new natural and synthetic compounds". Paper presented in XXVI Congresso Nazionale della Società Chimica Italiana, 2017.
  12. Doretta Cuffaro; Elisa Nuti; Eliisa Bernardini; Chaves, Sílvia; Armando Rossello. "Combined roles of zinc-binding groups and sulfur oxidation state to drive potency and selectivity in thioaryl-based inhibitors of MMP-12". Paper presented in EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry, 2017.
  13. Sara Conchinhas; Karam Chand; Chaves, Sílvia; M. Amélia Santos. "Silica-immobilized hydroxyquinoline as sorbent of metal ions from water resources". Paper presented in International Symposium on Metal Complexes ISMEC 2017, 2017.
  14. Asha Hiremathad; Rangappa S. Keri; Chaves, Sílvia; M. Amélia Santos. "Novel tacrine-hydroxyphenylbenzimidazole hybrids as potential drug candidates for Alzheimer´s disease". Paper presented in 11th Inorganic Chemistry Conference (ICC 11), 2016.
  15. Hesham S. Alsoghier; M.A.Selim; Chaves, Sílvia; M. Amélia Santos. "Benzothiazole-acetonitrile azo dyes as inhibitors of beta-amyloid chelation: metal-chelating and anti-oxidant properties". Paper presented in International Symposium on Metal Complexes, ISMEC 2015, 2015.
  16. Karam Chand; Hesham S. Alsoghier; Chaves, Sílvia; M. Amélia Santos. "Exploiting 2-pyridone derivatives in the search for novel multifunctional AD drugs: iron chelating and anti-oxidant properties". Paper presented in International Symposium on Metal Complexes, ISMEC 2015, 2015.
  17. M. Amélia Santos; Catarina Quintanova; S. Keri; Chaves, Sílvia; Diana F. Silva; Sandra M. Cardoso. "Tacrine-S-allylcysteine hybrids as potential multi-targeting drug candidates against Alzheimer’s Disease". Paper presented in Internat. Symp. Med. Chem (EFMC-ISMC), 2014.
  18. Chaves, Sílvia; Anabela Capelo; Laurinda Areias; Esteves, M. Alexandra. "Bidentate N-heterocyclic chelating agents for hard metal ions". Paper presented in International Symposium om Metal Complexes, ISMEC 2013, 2013.
  19. Sérgio Marques; Chaves, Sílvia; Claudia Abate; Elisa Nuti; Armando Rossello; M. Amélia Santos. "METALLOPROTEINASE INHIBITION: an inorganic approach towards biological improvements". Paper presented in Eurobic11, 11th European Biological Inorganic Chemistry Conference, 2012.
  20. Esteves, M. Alexandra; Anabela Capelo; Laurinda Areias; João Rocha; M. Amélia Santos; Chaves, Sílvia. "Metal-sorption Based on Hydroxypyrimidinone Functionalized Solid Supports". Paper presented in International Symposium om Metal Complexes, ISMEC 2012, 2012.
  21. Anabela Capelo; Laurinda Areias; Esteves, M. Alexandra; M. Lurdes Gano; Chaves, Sílvia; M. Amélia Santos. "Alkylamine-bearing N-heterocyclic chelators for hard metal ions". Paper presented in International Symposium om Metal Complexes, ISMEC 2012, 2012.
  22. Chaves, Sílvia; Andreia Nunes; Ranganath Keri; Sérgio Marques; M. Amélia Santos. "Bifunctional iron-chelators with prospective roles against neurodegenerative diseases". Paper presented in International Symposium om Metal Complexes, ISMEC 2012, 2012.
  23. Chaves, Sílvia; Anabela Capelo; Laurinda Areias; Sérgio Marques; Esteves, M. Alexandra; M. Amélia Santos. "A tripodal hydroxypyrimidinone –Gd chelate for potential diagnostic use". Paper presented in International Symposium om Metal Complexes, ISMEC 2012, 2012.
  24. Anabela Capelo; Laurinda Areias; Sérgio Marques; M. Lurdes Gano; Chaves, Sílvia; M. Alexandra Esteves; M. Amélia Santos. "A New Tripodal Hydroxypyrimidinone Sequestering Agent". Paper presented in International Symposium om Metal Complexes, ISMEC 2011, 2011.
  25. M. Alexandra Esteves; Anabela Capelo; Laurinda Areias; Chaves, Sílvia; M. Amélia Santos. "Synthesis and complexation properties of a new 2-aminoalkylamino-4,5-dihydroxypyrimidine chelator". Paper presented in XVI Encontro Luso-Galego de Química, 2010.
  26. M. Alexandra Esteves; Anabela Capelo; Laurinda Areias; João Rocha; Chaves, Sílvia; M. Amélia Santos. "Synthesis, Characterization, and Metal-Sequestering, Properties of New Hydroxypyrimidinone Functionalized Mesoporous Sílicas and Polystyrene Resins". Paper presented in 18th International Conference on Organic Synthesis (ICOS-18), 2010.
  27. Chaves, Sílvia; Sérgio Marques; Laurinda Areias; Anabela Capelo; Esteves, M. Alexandra; M. Lurdes Gano; M. Amélia Santos. "A Tripodal Hydroxypyrimidinone-based Compound for Iron and Aluminium Decorporation". Paper presented in ISMEC 2010, 2010.
  28. Andreia Nunes; Paul I. Dron; Chaves, Sílvia; M. Amélia Santos. "A Bifunctional Hydroxypyridinone-based Chelator with Anti-oxidant Activity as Potential Antineurodegenerative". Paper presented in ISMEC 2010, 2010.
  29. A.C. Mendonça; Sérgio Marques; Chaves, Sílvia; F. Martins; P. L. Zanonato; P. Di Bernardo; Melchior, Andrea; et al. "Spectroscopic studies on two mono nuclear iron (III) complexes derived from a schiff base and an azodye". 2009.
    10.1063/1.4898259
  30. Chaves, Sílvia; Ratomir Jelic; Edit Csapó; Florina A. Danalache; Daniel Silva; Etelka Farkas; M. Amélia Santos. "Molybdenum(VI) complexation of hydroxy(thio)pyridinones with potential biological significance". Paper presented in 10th International Symposium on Applied Bioinorganic Chemistry, ISABC 10, 2009.
  31. Paul I. Dron; Chaves, Sílvia; Florina A. Danalache; Diana Sacoto; M. Lurdes Gano; M. Amélia Santos. "Aluminum combined chelation with a glycosyl-mono- and a bis-hydroxypyridinone. Solution and biodistribution Studies". Paper presented in Eighth Keele Meeting on Aluminium, 2009.
  32. Ana C. Mendonça; Chaves, Sílvia; Sérgio Marques; André F. Martins; M.I.M. Prata; Ana C. Santos; Carlos F.G.C. Geraldes; M. Amélia Santos. "Gallium-(tris-hydroxypyridinone) Complex as a Potential Nuclear Imaging Agent. Complexation and Biodistribution". Paper presented in SIMEC-08, 2008.
  33. Sérgio Marques; Chaves, Sílvia; M. Amélia Santos. "New Tris-Hydroxypyridinone Chelating Agent for Metal Decorporation". Paper presented in 7ª Conferência de Química Inorgânica da Sociedade Portuguesa de Química, 2007.
  34. Clementina Teixeira; André, Vânia; Chaves, Sílvia; Hermínio Diogo; Nuno Lourenço. "Growing maltese giant crystals of sodium chloride: from the nursery to the university chemistry laboratory". Paper presented in Química Sustentável, XX Encontro Nacional da SPQ, 2006.
  35. M. Amélia Santos; Daniel Silva; Diana Sacoto; Marta Carrasco; Fernanda Vilhena; M. Lurdes Gano; Chaves, Sílvia. "Hydroxy(thio)pyridinones. New Chelating Agents for Potential Pharmacological Applications". Paper presented in 16th International Conference on Chelators for the Treatment of Thalassaemia, Cancer and other Diseases related to Metal and Free Radical Imbalance and Toxicity, 2006.
  36. Clementina Teixeira; Chaves, Sílvia. "Experiências para a raia miúda". Paper presented in 4º DEDQ, 4º Encontro Nacional da Divisão de Ensino e Divulgação da Química, 2005.
  37. M. Alexandra Esteves; Anabela Cachudo; Chaves, Sílvia; M. Amélia Santos. "Synthesis and chelating properties of a new sulfonamide-hydroxypyrimidinone chelator". Paper presented in ICSC 29, 29th International Conference on Solution Chemistry, 2005.
  38. M. Alexandra Esteves; Anabela Cachudo; Chaves, Sílvia; M. Amélia Santos. "New Functionalised Supports for Potential Sorption of Metal Traces from Aqueous Fluids". Paper presented in Sixth Keele Meeting on Aluminium, 2005.
  39. Sérgio Marques; Chaves, Sílvia; A. Scozzafava; C.T. Supuran; A. Rossello; M. Amélia Santos. "Carbonic Anhydrase and Matrix Metalloproteinase Inhibitors. Sulfonamide Incorporating Iminodiacetic and Hydroxamate Moieties". Paper presented in Eurobic-7, European Conference on Biological Inorganic Chemistry, 2004.
  40. M. Amélia Santos; Marco Gil; M. Lurdes Gano; Chaves, Sílvia. "Bi-functional 3-hydroxy-4-pyridinone derivatives: interactions with Al(III) and speciation models in view of Al-detoxification roles". Paper presented in Third International Conference in Trace Element Speciation in Biomedical, Nutritional and Environmental Sciences, 2004.
  41. M. Alexandra Esteves; Anabela Cachudo; Chaves, Sílvia; M. Amélia Santos. "Synthesis and complexation properties of new 4-aminoalkyl hydroxypyrimidinone ligands". Paper presented in XIX Encontro Nacional da Sociedade Portuguesa de Química, 2004.
  42. André Matos; Chaves, Sílvia; Nuno Bandeira; M. Amélia Santos. "A tripodal 3-hydroxy-4-pyridinone NTA derivative as a new iron sequestering agent". Paper presented in XIX Encontro Nacional da Sociedade Portuguesa de Química, 2004.
  43. Sérgio Marques; Marco Gil; Chaves, Sílvia; M. Amélia Santos. "Alkyl-aryl derivatives of 3-hydroxy-4-pyridinones as chelating agents for hard metals with potential pharmaceutical application". Paper presented in 7 th FIGIPS Meeting in Inorganic Chemistry, European Mediterranean Conference in Inorganic Chemistry, 2003.
  44. M. Alexandra Esteves; Anabela Cachudo; Chaves, Sílvia; M. Amélia Santos. "Synthesis and complexation properties of a new hydroxypyrimidinone functionalized support". Paper presented in 7 th FIGIPS Meeting in Inorganic Chemistry, European Mediterranean Conference in Inorganic Chemistry, 2003.
  45. Marco Gil; Chaves, Sílvia; Sergio Marques; M. Amélia Santos. "Aryl-amino derivatives of 3-hydroxy-4-pyridinones as aluminium chelating agents with potential medicinal application". Paper presented in Fifth Keele Meeting on Aluminium, 2003.
  46. Chaves, Sílvia; Marco Gil; M. Lurdes Gano; M. Amélia Santos. "Potential Sigma Receptor-Binding 3-Hydroxy-4-Pyridinones. Synthesis, complexation with Fe, Al, Ga and 67Ga Biodistribution". Paper presented in Eurobic-6, European Conference on Biological Inorganic Chemistry, 2002.
  47. M. Alexandra Esteves; Anabela Cachudo; Chaves, Sílvia; M. Amélia Santos. "Synthesis and chelating properties of a new 4-aminoalkyl hydroxypyrimidinone derivative". Paper presented in Eurobic-6, European Conference on Biological Inorganic Chemistry, 2002.
    10.1063/1.5065064
  48. Marco Gil; Chaves, Sílvia; Daniel Silva; Sérgio Marques; M. Lurdes Gano; M. Amélia Santos. "Bifunctional N-carboxyalkyl-3-hydroxy-4-pyridinones. Synthesis, complexation with the Fe(III), Al(III) and Ga(III) and biological evaluation". Paper presented in 6th FIGIPS Meeting in Inorganic Chemistry, European Mediterranean Conference in Inorganic Chemistry, 2001.
  49. João Costa Pessoa; Chaves, Sílvia; S. Cavaqueira; Susana M. Luz. "The systems GlySer and SerGly + VIVO2+. A potentiometric and spectroscopic study". Paper presented in Eurobic-5, 5th European Biological Inorganic Chemistry Conference, 2000.
  50. Chaves, Sílvia; João Costa Pessoa; Susana M. Luz. "Complexos de oxovanádio(IV) com os dipeptídeos GlySer e SerGly em solução aquosa". Paper presented in XII Encontro Nacional da Sociedade Portuguesa de Química, 2000.
  51. Chaves, Sílvia; Ana Cerva; Rita Delgado. "1-oxa-4,8,12-triazacyclotetradecane-4,8,12-triacetic acid: protonation and metal complexation studies". Paper presented in 3ª Conferência em Química Inorgânica da Sociedade Portuguesa de Química, 1997.
  52. Chaves, Sílvia; Rita Delgado. "Ligandos Macrocíclicos do Tipo Oxa-Triaza com Substituintes Carboximetilo". Paper presented in XV Encontro Nacional da Sociedade Portuguesa de Química, 1996.
  53. Rita Delgado; M. Teresa Amorim; Chaves, Sílvia; Isabel Moura; J.J.R. Fraústo da Silva. "Estudo de complexos de cobre(II) de ligandos macrocíclicos do tipo oxatriaza por espectroscopia de RPE". Paper presented in XIV Encontro Nacional da Sociedade Portuguesa de Química,, 1994.
  54. Chaves, Sílvia; Rita Delgado. "1,4-dioxa-7,11-diazacyclotridecane-7,11-diacetic acid: protonation and metal complexation studies". Paper presented in XVIII International Symposium on Macrocyclic Chemistry, 1993.
  55. Chaves, Sílvia; Rita Delgado; M. Teresa Duarte. "Studies on 1-oxa-4,8,12-triazacyclotetradecane-4,12-diacetic Acid. X-Ray Structure of its Copper(II) Complex". Paper presented in Sixteenth International Symposium on Macrocyclic Chemistry, 1991.
  56. M.A.A.F. de C.T. Carrondo; Vítor Félix; M. Teresa Amorim; Chaves, Sílvia; Rita Delgado; M. Teresa Duarte. "Crystallographic Studies on oxa-triazamacrocyclic copper complexes". Paper presented in Thirteenth European Crystallographic Meeting, 1991.
  57. M. Teresa Amorim; Chaves, Sílvia; Rita Delgado; J.J.R. Fraústo da Silva. "Macrociclos do tipo oxa-triaza - estudos de protonação e complexação". Paper presented in XII Encontro da Sociedade Portuguesa de Química, 1991.
  58. M. Teresa Amorim; M. Fátima Cabral; Chaves, Sílvia; Judite Costa; Rita Delgado; J.J.R. Fraústo da Silva. "Nuclear Magnetic Resonance Studies of the Acid-Base Chemistry of Some Polyoxa- Polyaza Macrocyclic Compounds". Paper presented in First Meeting of the Portuguese Association of Magnetic Resonance on Science and Medicine, 1990.
  59. M. Teresa Amorim; Chaves, Sílvia; Rita Delgado. "Metal Complexes of some Polyoxa-Polyaza Macrocyclic Ligands". Paper presented in Italian, Portuguese, Spanish Meeting in Inorganic Chemistry, 1990.
  60. M.A.A.F. de C.T. Carrondo; Chaves, Sílvia; Rita Delgado; M. Teresa Leal S. Duarte; Vítor Félix. "Metal Complexation of the 1-oxa-4,8,12-triazacyclotetra-decane and its N-methylated Derivative. X-Ray Study on a Copper(II) Complex". Paper presented in Italian, Portuguese Spanish Meeting in Inorganic Chemistry, Gandía, 1990.
  61. M. Teresa Amorim; J.R. Ascenso; Chaves, Sílvia; Rita Delgado; J.J.R. Fraústo da Silva. "Sequência de protonação de ligandos macrocíclicos do tipo oxa-poliaza e seus derivados di- e tri-carboxilatos". Paper presented in XI Encontro Anual da Sociedade Portuguesa de Química, 1988.
  62. M. Teresa Amorim; M. Fátima Cabral; Chaves, Sílvia; Judite Costa; Rita Delgado; J.J.R. Fraústo da Silva. "Synthesis and Complexation Reactions of N-acetate derivatives of some oxa-polyaza macrocyclic ligands". Paper presented in XIII International Symposium on Macrociclic Chemistry, 1988.
Journal article
  1. Rosalba Leuci; Stefan Simic; Antonio Carrieri; Sílvia Chaves; Gabriella La Spada; Leonardo Brunetti; Paolo Tortorella; et al. "Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates". Bioorganic Chemistry (2024): https://doi.org/10.1016/j.bioorg.2024.107895.
    10.1016/j.bioorg.2024.107895
  2. Leo Bon; Angelika Banas; Inês Dias; Inês Melo-Marques; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos. "New Multitarget Rivastigmine–Indole Hybrids as Potential Drug Candidates for Alzheimer’s Disease". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16020281.
    10.3390/pharmaceutics16020281
  3. M. Amelia Santos; Sílvia Chaves. "Controlo de Biometais no Contexto de Fármacos Multifuncionais para a Doença de Alzheimer". Boletim da Sociedade Portuguesa de Química 47 171 (2024): 255-263. http://dx.doi.org/10.52590/m3.p708.a30002748.
    Published • 10.52590/m3.p708.a30002748
  4. David Vicente-Zurdo; Leonardo Brunetti; Luca Piemontese; Beatriz Guedes; Sandra M. Cardoso; Daniel Chavarria; Fernanda Borges; et al. "Rivastigmine–Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24098312.
    10.3390/ijms24098312
  5. Alessia Carocci; Alexia Barbarossa; Rosalba Leuci; Antonio Carrieri; Leonardo Brunetti; Antonio Laghezza; Marco Catto; et al. "Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease". Antioxidants (2022): https://doi.org/10.3390/antiox11091631.
    10.3390/antiox11091631
  6. David Vicente-Zurdo; Noelia Rosales-Conrado; M. Eugenia León-González; Leonardo Brunetti; Luca Piemontese; A. Raquel Pereira-Santos; Sandra M. Cardoso; et al. "Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease". Biomedicines (2022): https://doi.org/10.3390/biomedicines10071510.
    10.3390/biomedicines10071510
  7. M. A. Santos; ANNA IRTO; Péter Buglyó; Sílvia Chaves. "Hydroxypyridinone-Based Metal Chelators towards Ecotoxicity: Remediation and Biological Mechanisms". Molecules (2022): https://www.mdpi.com/1420-3049/27/6/1966.
    10.3390/molecules27061966
  8. Silvia Chaves; Karolina Gwizdala; Karam Chand; Lurdes Gano; Agnès Pallier; Éva Tóth; M. Amélia Santos. "GdIII and GaIII complexes with a new tris-3,4-HOPO ligand as new imaging probes: complex stability, magnetic properties and biodistribution". Dalton Transactions 51 16 (2022): 6436-6447. https://doi.org/10.1039/D2DT00066K.
    10.1039/D2DT00066K
  9. Sílvia Chaves; Katalin Várnagy; M. Amélia Santos. "Recent Multi-target Approaches on the Development of Anti-Alzheimer's Agents Integrating Metal Chelation Activity". Current Medicinal Chemistry (2021): https://doi.org/10.2174/0929867328666210218183032.
    10.2174/0929867328666210218183032
  10. Beatrice Bargagna; LIDIA CICCONE; SUSANNA NENCETTI; M. A. Santos; Sílvia Chaves; Caterina Camodeca; Elisabetta Orlandini. "Multifunctional Small Molecules as Potential Anti-Alzheimer’s Disease Agents". Molecules (2021): https://www.mdpi.com/1420-3049/26/19/6015.
    10.3390/molecules26196015
  11. Fausto Queda; Sonia Calò; Karolina Gwizdala; João D. Magalhães; Sandra M. Cardoso; Sílvia Chaves; Luca Piemontese; M. Amélia Santos. "Novel Donepezil–Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer’s Disease". Molecules 26 6 (2021): 1658-1658. https://doi.org/10.3390/molecules26061658.
    10.3390/molecules26061658
  12. Hiremathad, Asha; Chaves, Sílvia; Keri, Rangappa S.. "Multi-Targeting Tacrine Conjugates with Cholinesterase and Amyloid-Beta Inhibitory Activities: New Anti-Alzheimer's Agents". Chemistry & Biodiversity 18 2 (2021): http://dx.doi.org/10.1002/cbdv.202000083.
    Published • 10.1002/cbdv.202000083
  13. Poliseno, Viviana; Chaves, Sílvia; Brunetti, Leonardo; Loiodice, Fulvio; Carrieri, Antonio; Laghezza, Antonio; Tortorella, Paolo; et al. "Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents". Biomolecules 11 1 (2021): 111. http://dx.doi.org/10.3390/biom11010111.
    10.3390/biom11010111
  14. Costa, Marina; Josselin, Romane; Silva, Diana F.; Cardoso, Sandra M.; May, Nóra V.; Chaves, Sílvia; Santos, M. Amélia. "Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization". Journal of Inorganic Biochemistry 206 (2020): 111039. http://dx.doi.org/10.1016/j.jinorgbio.2020.111039.
    Published • 10.1016/j.jinorgbio.2020.111039
  15. Sílvia Chaves; Simonetta Resta; Federica Rinaldo; Marina Costa; Romane Josselin; Karolina Gwizdala; Luca Piemontese; et al. "Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease". Molecules 25 4 (2020): E985. https://www.mdpi.com/1420-3049/25/4/985.
    In press • 10.3390/molecules25040985
  16. Gaia Fancellu; Karam Chand; Daniel Tomás; Elisabetta Orlandini; Luca Piemontese; Diana F. Silva; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos. "Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease". Journal of Enzyme Inhibition and Medicinal Chemistry (2020): https://doi.org/10.1080/14756366.2019.1689237.
    10.1080/14756366.2019.1689237
  17. Valeria M. Nurchi; Rosita Cappai; Karam Chand; Sílvia Chaves; Lurdes Gano; Guido Crisponi; Massimiliano Peana; M. Antonietta Zoroddu; M. Amélia Santos. "New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation". Dalton Transactions 48 (2019): 16167-16183. https://doi.org/10.1039/C9DT02905B.
    Published • 10.1039/C9DT02905B
  18. Rajeshwari Rajeshwari; karam Chand; Emanuel Candeias; Cardoso SM; Sílvia Chaves; M. A. Santos. "New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease". Molecules 24 3 (2019): 587. http://www.mdpi.com/1420-3049/24/3/587.
    Published • 10.3390/molecules24030587
  19. Nuti, Elisa; Cuffaro, Doretta; Bernardini, Elisa; Camodeca, Caterina; Panelli, Laura; Chaves, Sílvia; Ciccone, Lidia; et al. "Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies". Journal of Medicinal Chemistry 61 10 (2018): 4421-4435. http://dx.doi.org/10.1021/acs.jmedchem.8b00096.
    10.1021/acs.jmedchem.8b00096
  20. Hiremathad, Asha; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia. "Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease". European Journal of Medicinal Chemistry 148 (2018): 255-267. http://dx.doi.org/10.1016/j.ejmech.2018.02.023.
    Published • 10.1016/j.ejmech.2018.02.023
  21. Luca Piemontese; Daniel Tomás; Asha Hiremathad; Vito Capriati; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos. "Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates". Journal of Enzyme Inhibition and Medicinal Chemistry 33 1 (2018): 1212-1224. https://doi.org/10.1080/14756366.2018.1491564.
    Published • 10.1080/14756366.2018.1491564
  22. Sílvia Chaves; Asha Hiremathad; Daniel Tomás; Rangappa S. Keri; Luca Piemontese; M. Amélia Santos. "Exploring the chelating capacity of 2-hydroxyphenyl-benzimidazole based hybrids with multi-target ability as anti-Alzheimer's agents". New Journal of Chemistry 42 20 (2018): 16503-16515. https://doi.org/10.1039/C8NJ00117K.
    Published • 10.1039/C8NJ00117K
  23. Karam Chand; Rajeshwari Rajeshwari; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos. "Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug". Metallomics 10 10 (2018): 1460-1475. https://doi.org/10.1039/C8MT00143J.
    Published • 10.1039/C8MT00143J
  24. Rosita Cappai; Karam Chand; Joanna I. Lachowicz; Sílvia Chaves; Lurdes Gano; Guido Crisponi; Valeria M. Nurchi; et al. "A new tripodal-3-hydroxy-4-pyridinone for iron and aluminium sequestration: synthesis, complexation and in vivo studies". New Journal of Chemistry 42 10 (2018): 8050-8061. https://doi.org/10.1039/C8NJ00116B.
    Published • 10.1039/C8NJ00116B
  25. Chaves, S.; Piemontese, L.; Hiremathad, A.; Santos, M.A.. "Hydroxypyridinone derivatives: A fascinating class of chelators with therapeutic applications - An update". Current Medicinal Chemistry 25 1 (2018): 1-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040811746&partnerID=MN8TOARS.
    Published • 10.2174/0929867324666170330092304
  26. Hiremathad, A.; Chand, K.; Tolayan, L.; Rajeshwari; Keri, R.S.; Esteves, A.R.; Cardoso, S.M.; Chaves, S.; Santos, M.A.. "Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy". Journal of Inorganic Biochemistry 179 (2018): 82-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034846822&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2017.11.015
  27. Santos, M. Amélia; Chand, Karam; Chaves, Silvia. "Recent progress in multifunctional metal chelators as potential drugs for Alzheimer's disease". Coordination Chemistry Reviews 327-328 (2016): 287-303. http://dx.doi.org/10.1016/j.ccr.2016.04.013.
    Published • 10.1016/j.ccr.2016.04.013
  28. Santos, M.A.; Chand, K.; Chaves, S.. "Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy". Future Medicinal Chemistry 8 17 (2016): 2113-2142. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994054736&partnerID=MN8TOARS.
    Published • 10.4155/fmc-2016-0103
  29. Hiremathad, Asha; Chand, Karam; Esteves, A. Raquel; Cardoso, Sandra M.; Ramsay, Rona R.; Chaves, Sílvia; Keri, Rangappa S.; Santos, M. Amélia. "Tacrine-allyl/propargylcysteine–benzothiazole trihybrids as potential anti-Alzheimer's drug candidates". RSC Advances 6 58 (2016): 53519-53532. http://dx.doi.org/10.1039/c6ra03455a.
    Published • 10.1039/c6ra03455a
  30. Keri, Rangappa S.; Quintanova, Catarina; Chaves, Sílvia; Silva, Diana F.; Cardoso, Sandra M.; Santos, M. Amélia. "New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease". Chemical Biology & Drug Design 87 1 (2015): 101-111. http://dx.doi.org/10.1111/cbdd.12633.
    10.1111/cbdd.12633
  31. Santos, M Amélia; Chaves, Sílvia. "3-hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use". Future Medicinal Chemistry 7 3 (2015): 383-410. http://dx.doi.org/10.4155/fmc.14.162.
    Published • 10.4155/fmc.14.162
  32. Quintanova, C.; Keri, R.S.; Chaves, S.; Santos, M.A.. "Copper(II) complexation of tacrine hybrids with potential anti-neurodegenerative roles". Journal of Inorganic Biochemistry 151 (2015): 58-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949627585&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2015.06.008
  33. Chand, K.; Alsoghier, H.M.; Chaves, S.; Santos, M.A.. "Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer's agents: AChE inhibition, antioxidant activity and metal chelating capacity". Journal of Inorganic Biochemistry (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84971645683&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2016.05.005
  34. Mendonça, A.C.; Martins, A.F.; Melchior, A.; Marques, S.M.; Chaves, S.; Villette, S.; Petoud, S.; et al. "New tris-3,4-HOPO lanthanide complexes as potential imaging probes: Complex stability and magnetic properties". Dalton Transactions 42 17 (2013): 6046-6057. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875798226&partnerID=MN8TOARS.
    Published • 10.1039/c2dt32237d
  35. Marques, S.M.; Abate, C.C.; Chaves, S.; Marques, F.; Santos, I.; Nuti, E.; Rossello, A.; Santos, M.A.. "New bifunctional metalloproteinase inhibitors: An integrated approach towards biological improvements and cancer therapy". Journal of Inorganic Biochemistry 127 (2013): 188-202. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884417690&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2013.03.003
  36. Chaves, S.; Capelo, A.; Areias, L.; Marques, S.M.; Gano, L.; Esteves, M.A.; Santos, M.A.. "A novel tripodal tris-hydroxypyrimidinone sequestering agent for trivalent hard metal ions: Synthesis, complexation and in vivo studies". Dalton Transactions 42 17 (2013): 6033-6045. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875801298&partnerID=MN8TOARS.
    Published • 10.1039/c2dt32361c
  37. Nunes, A.; Marques, S.M.; Quintanova, C.; Silva, D.F.; Cardoso, S.M.; Chaves, S.; Santos, M.A.. "Multifunctional iron-chelators with protective roles against neurodegenerative diseases". Dalton Transactions 42 17 (2013): 6058-6073. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875780884&partnerID=MN8TOARS.
    Published • 10.1039/c3dt50406a
  38. Santos, M.A.; Esteves, M.A.; Chaves, S.. "Hydroxypyri(mi)dine-based chelators as antidotes of toxicity due to aluminum and actinides". Current Medicinal Chemistry 19 17 (2012): 2773-2793. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861856437&partnerID=MN8TOARS.
    Published
  39. Chaves, S.; Canário, S.; Carrasco, M.P.; Mira, L.; Santos, M.A.. "Hydroxy(thio)pyrone and hydroxy(thio)pyridinone iron chelators: Physico-chemical properties and anti-oxidant activity". Journal of Inorganic Biochemistry 114 (2012): 38-46. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861937012&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2012.04.019
  40. Santos, M.A.; Marques, S.M.; Chaves, S.. "Hydroxypyridinones as " privileged" chelating structures for the design of medicinal drugs". Coordination Chemistry Reviews 256 1-2 (2012): 240-259. http://www.scopus.com/inward/record.url?eid=2-s2.0-82355175854&partnerID=MN8TOARS.
    Published • 10.1016/j.ccr.2011.08.008
  41. Chaves, S.; Mendonça, A.C.; Marques, S.M.; Prata, M.I.; Santos, A.C.; Martins, A.F.; Geraldes, C.F.G.C.; Santos, M.A.. "A gallium complex with a new tripodal tris-hydroxypyridinone for potential nuclear diagnostic imaging: Solution and in vivo studies of 67Ga- labeled species". Journal of Inorganic Biochemistry 105 1 (2011): 31-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-78249277878&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2010.09.012
  42. Chaves, Sílvia; Marques, Sérgio M.; Matos, André M. F.; Nunes, Andreia; Gano, Lurdes; Tuccinardi, Tiziano; Martinelli, Adriano; Santos, M. Amélia. "New Tris(hydroxypyridinones) as Iron and Aluminium Sequestering Agents: Synthesis, Complexation and In Vivo Studies". Chemistry - A European Journal 16 34 (2010): 10535-10545. http://dx.doi.org/10.1002/chem.201001335.
    Published • 10.1002/chem.201001335
  43. Chaves, S.; Jelic, R.; Mendonça, C.; Carrasco, M.; Yoshikawa, Y.; Sakuraid, H.; Santos, M.A.. "Complexes of hydroxy(thio)pyrone and hydroxy(thio)pyridinone with Zn(II) and Mo(VI). Thermodynamic stability and insulin-mimetic activity". Metallomics 2 3 (2010): 220-227. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953656441&partnerID=MN8TOARS.
    Published • 10.1039/b914169c
  44. Chaves, S.; Dron, P.I.; Danalache, F.A.; Sacoto, D.; Gano, L.; Santos, M.A.. "Combined chelation based on glycosyl-mono- and bis-hydroxypyridinones for aluminium mobilization: Solution and biodistribution studies". Journal of Inorganic Biochemistry 103 11 (2009): 1521-1529. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350004070&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2009.07.026
  45. Gama, S.; Dron, P.; Chaves, S.; Farkas, E.; Santos, M.A.. "A bis(3-hydroxy-4-pyridinone)-EDTA derivative as a strong chelator for M3+ hard metal ions: Complexation ability and selectivity". Dalton Transactions 31 (2009): 6141-6150. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149122263&partnerID=MN8TOARS.
    Published • 10.1039/b904950a
  46. Arduino, D.; Silva, D.; Cardoso, S.M.; Chaves, S.; Oliveira, C.R.; Santos, M.A.. "New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs". Frontiers in Bioscience 13 17 (2008): 6763-6774. http://www.scopus.com/inward/record.url?eid=2-s2.0-52049107811&partnerID=MN8TOARS.
    Published
  47. Chaves, S.; Gil, M.; Canário, S.; Jelic, R.; Romão, M.J.; Trincão, J.; Herdtweck, E.; et al. "Biologically relevant O,S-donor compounds. Synthesis, molybdenum complexation and xanthine oxidase inhibition". Dalton Transactions 13 (2008): 1773-1782. http://www.scopus.com/inward/record.url?eid=2-s2.0-40849130962&partnerID=MN8TOARS.
    Published • 10.1039/b717172b
  48. Amélia Santos, M.; Gil, M.; Gano, L.; Chaves, S.. "Erratum: Bifunctional 3-hydroxy-4-pyridinone derivatives as potential pharmaceuticals: Synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation with 67Ga (Journal of Biological Inorganic Chemistry (2005) 10 (564-580) DOI: 10.1007/s00775-005-0003-7)". Journal of Biological Inorganic Chemistry 11 7 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33748348637&partnerID=MN8TOARS.
    Published • 10.1007/s00775-006-0149-y
  49. Chaves, S.; Marques, S.M.; Cachudo, A.; Esteves, M.A.; Santos, M.A.. "Zinc(II) complexation behaviour of sulfonamide-based enzyme inhibitors". European Journal of Inorganic Chemistry 19 (2006): 3853-3860. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749820518&partnerID=MN8TOARS.
    Published • 10.1002/ejic.200600443
  50. Santos, M. Amélia; Gil, Marco; Gano, Lurdes; Chaves, Sílvia. "Bifunctional 3-hydroxy-4-pyridinone derivatives as potential pharmaceuticals: synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation with 67Ga". JBIC Journal of Biological Inorganic Chemistry 10 5 (2005): 564-580. http://dx.doi.org/10.1007/s00775-005-0003-7.
    Published • 10.1007/s00775-005-0003-7
  51. Santos, M.A.; Gil, M.; Marques, S.; Gano, L.; Chaves, S.. "N-Arylamine derivatives of 3-hydroxy-4-pyridinones: Solution studies and bioevaluation in view of Al-detoxification roles". Analytical and Bioanalytical Chemistry 381 2 (2005): 413-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844257059&partnerID=MN8TOARS.
    Published • 10.1007/s00216-004-2823-7
  52. Esteves, M.A.; Cachudo, A.; Chaves, S.; Santos, M.A.. "Synthesis and metal-complexation properties of a new hydroxypyrimidinone- functionalized sepharose". European Journal of Inorganic Chemistry 3 (2005): 597-605. http://www.scopus.com/inward/record.url?eid=2-s2.0-14544275889&partnerID=MN8TOARS.
    Published • 10.1002/ejic.200400355
  53. Esteves, M.A.; Cachudo, A.; Chaves, S.; Santos, M.A.. "New silica-immobilized hydroxypyrimidinone as sorbent of hard metal ions from aqueous fluids". Journal of Inorganic Biochemistry 99 9 SPEC. IS (2005): 1762-1768. http://www.scopus.com/inward/record.url?eid=2-s2.0-24344485531&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2005.06.012
  54. Chaves, S.; Marques, S.; Santos, M.A.. "Iminodiacetyl-hydroxamate derivatives as metalloproteinase inhibitors: Equilibrium complexation studies with Cu(II), Zn(II) and Ni(II)". Journal of Inorganic Biochemistry 97 4 (2003): 345-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142058135&partnerID=MN8TOARS.
    Published • 10.1016/S0162-0134(03)00286-1
  55. Arnaud-Neu, F.; Delgado, R.; Chaves, S.. "Critical evaluation of stability constants and thermodynamic functions of metal complexes of crown ethers: (IUPAC technical report)". Pure and Applied Chemistry 75 1 (2003): 71-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037222150&partnerID=MN8TOARS.
    Published
  56. Chaves, S.; Gil, M.; Marques, S.E.; Gano, L.; Santos, M.A.. "Alkylaryl-amino derivatives of 3-hydroxy-4-pyridinones as aluminium chelating agents with potential clinical application". Journal of Inorganic Biochemistry 97 1 (2003): 161-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141851353&partnerID=MN8TOARS.
    Published • 10.1016/S0162-0134(03)00238-1
  57. Santos, M.A.; Gil, M.; Marques, S.; Gano, L.; Cantinho, G.; Chaves, S.. "N-Carboxyalkyl derivatives of 3-hydroxy-4-pyridinones: Synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation". Journal of Inorganic Biochemistry 92 1 (2002): 43-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037201554&partnerID=MN8TOARS.
    Published • 10.1016/S0162-0134(02)00483-X
  58. Chaves, S.; Cerva, A.; Delgado, R.. "13-Membered macrocycles and their complexometric properties: Study of 7,11-bis(carboxymethyl)-1,4-dioxa-7,11-diazacyclotridecane". Polyhedron 17 1 (1998): 93-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-0010648665&partnerID=MN8TOARS.
    Published
  59. Chaves, S.; Cerva, A.; Delgado, R.. "Tris(carboxymethyl)oxatriazamacrocycles and their metal complexes". Journal of the Chemical Society - Dalton Transactions 22 (1997): 4181-4189. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748674256&partnerID=MN8TOARS.
    Published
  60. Félix, V.; Delgado, R.; Amorim, M.T.S.; Chaves, S.; Galvão, A.M.; Duarte, M.T.; Carrondo, M.A.A.F.D.C.T.; Moura, I.; Fraústo Da Silva, J.J.R.. "Electron spin resonance studies and crystal structures of copper(II) complexes of some 12-, 13- and 14-membered oxatriaza macrocycles". Journal of the Chemical Society, Dalton Transactions 21 (1994): 3099-3106. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049066588&partnerID=MN8TOARS.
    Published • 10.1039/DT9940003099
  61. Chaves, S.; Delgado, R.; Da Silva, J.J.R.F.. "The stability of the metal complexes of cyclic tetra-aza tetra-acetic acids". Talanta 39 3 (1992): 249-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000214935&partnerID=MN8TOARS.
    Published • 10.1016/0039-9140(92)80028-C
  62. Chaves, S.; Delgado, R.; Duarte, M.T.; Silva, J.A.L.; Félix, V.; De C. T. Carrondo, M.A.A.F.. "1-Oxa-4,8,12-triazacyclotetradecane-4,12-diacetic acid (H2L 2): Studies on protonation and metal complexation; Crystal structure of [cuL2]·5H2O". Journal of the Chemical Society, Dalton Transactions 17 (1992): 2579-2584. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049089240&partnerID=MN8TOARS.
    Published • 10.1039/DT9920002579
  63. Delgado, R.; Da Silva, J.J.R.F.; Amorim, M.T.S.; Cabral, M.F.; Chaves, S.; Costa, J.. "Dissociation constants of BrØnsted acids in D2O and H2O: studies on polyaza and polyoxa-polyaza macrocycles and a general correlation". Analytica Chimica Acta 245 C (1991): 271-282. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025892075&partnerID=MN8TOARS.
    Published • 10.1016/S0003-2670(00)80232-9
  64. Amorim, M.T.S.; Chaves, S.; Delgado, R.; Da Silva, J.J.R.F.. "Oxatriaza macrocyclic ligands: Studies of protonation and metal complexation". Journal of the Chemical Society, Dalton Transactions 11 (1991): 3065-3072. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049085212&partnerID=MN8TOARS.
    Published • 10.1039/DT9910003065
Thesis / Dissertation
  1. Chaves, Sílvia. "Complexos de macrociclos oxa-triaza e dioxa-diaza". PhD, Universidade de Lisboa Instituto Superior Técnico, 1998.

Intellectual property

Patent
  1. M. Amélia Santos; Sérgio Marques; M.A. Dias de Sousa Gil; Matteo Tegoni; Chaves, Sílvia. 2005. "Set of Medicinal Metal Enzyme High Capacity Inhibitors Comprises Succinic and Iminodiacetic Acids Giving High Zinc and Nickel Ion Complexing Capacity". Portugal.
    Granted/Issued
  2. M. Amélia Santos; Sérgio Marques; Marco Gil; Matteo Tegoni; Chaves, Sílvia. 2003. "Novos Inibidores de Metalo-Enzimas com Potencial Aplicação em Medicina". Portugal.
    Granted/Issued
  3. M. Alexandra Esteves; M. Amélia Santos; Anabela Cachudo; Chaves, Sílvia. 2003. "Suportes funcionalizados com Hidroxipirimidinonas para remoção de iões metálicos tóxicos em meios aquosos". Portugal.
    Granted/Issued

Other

Other output
  1. A New Dihydroxypyrimidine Chelator for Functionalization of Solid Supports. Comunicação oral em XXII Encontro Nacional da SPQ. 2011. Anabela Capelo; Laurinda Areias; Esteves, M. Alexandra; Chaves, Sílvia; M. Amélia Santos.
  2. Peptide derivatives of 3-hydroxy-4-pyridinone with potential medicinal application for radiodiagnosis. Comunicação oral em 9 th Iberian Peptide Meeting. 2004. Marco Gil; Fernando Albericio; Chaves, Sílvia; M. Lurdes Gano; M. Amélia Santos.
  3. Síntese, estudos de protonação e de complexação do ácido 1-oxa-4,8,11-triazaciclotridecano-4,8,11-triacético. Comunicação oral em 2ª Conferência de Química Inorgânica da Sociedade Portuguesa de Química. 1995. Chaves, Sílvia; Rita Delgado.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/06 A new tripodal 3-hydroxy-4-pyridinone: synthesis, protonation, complex formation studies with Fe3+, Al3+ and Zn2+, and in vivo bioassays International Symposium on Metal Complexes ISMEC 2019
University of Debrecen (Debrecen, Hungary)
2018/09 Deep eutectic solvents as effective media for the synthesis of Donepezil structure-based hybrids with metal-chelating properties XXXVIII Convegno Nazionale della Divisione di Chimica Organica della Società Chimica Italiana - CDCO 2018
(Milano, Italy)
2018/06 Hydroxyphenyl-benzymidazole based hybrids as metal chelating mimetics of the anti-Alzheimer´s drug Donepezil International Symposium on Metal Complexes ISMEC 2018
University of Florence (Florença, Italy)
2017/06/11 Tacrine-hydroxypyridinone hybrids as anti-acetylcholinesterase agents with metal ion binding capacity International Symposium on Metal Complexes ISMEC 2017
University of Dijon (Dijon, France)
2017/06/07 Exploiting hydroxyphenylbenzimidazol-based hybrids for metal-modulation in potential anti-Alzheimer´s drugs 14th International Symposium on Applied Bioinorganic Chemistry ISABC14
(Toulouse, France)
2016/08/28 New Multi-target Compounds for Modulation of Metal-dependent Toxicity in Alzheimer´s Disease 13th European Biological Inorganic Chemistry Conference (EuroBIC 13)
(Budapeste, Hungary)
2015/09/01 Metal-targeting in multifunctional drugs against Alzheimer´s disease XIII International Symposium on Inorganic Biochemistry
(Karpacz, Poland)
2014/06 Copper(II)-binding to (Tacrine-S-allyl)- and(Tacrine-S-propargyl)-cysteine as potential antineurodegenerative hybrid drugs International Symposium on Metal Complexes, ISMEC 2014
University of Pavia (Pavia, Italy)
2013/06 A bifunctional tripodal hydroxypyrimidinone-based iron chelator International Symposium on Metal Complexes, ISMEC 2013
University of Burgos (Burgos, Spain)
1996/06/25 Metal complexation studies of N-carboxymethylated derivatives of oxa-aza macrocyclic ligands XXI International Symposium on Macrocyclic Chemistry
Florence University (Montecatini Terme, Italy)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2017/07/10 - 2027/07/21 Determinação da actividade inibitória enzimática de compostos anti-neurodegenerativos
Supervisor
 EstVerDEQ 2017 (Scientific initiation)
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2019/09 - 2020/02 Tenuazonic acid derivatives as potential anti-Alzheimer´s disease agents
Co-supervisor
Università degli Studi di Bari Aldo Moro, Italy

Universidade de Lisboa Centro de Química Estrutural, Portugal
2019/07 - 2019/09 Evaluation of multifunctional anti-neurodegenerative compounds
Supervisor
 Erasmus+ (Specialization course)
Universidade de Lisboa Centro de Química Estrutural, Portugal

Politechnika Gdanska, Poland
2019/07/08 - 2019/07/19 Estudo físico-químico e biológico de compostos anti-neurodegenerativos.
Supervisor
 EstVerDEQ 2019 (Scientific initiation)
2018/07/09 - 2018/07/20 Potenciais fármacos anti-Alzheimer: estudo biológico e físico-químico.
Supervisor
 EstVerDEQ 2018 (Scientific initiation)
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2018/06 - 2018/07 Evaluation of multifunctional anti-neurodegenerative compounds
Supervisor
Universidade de Lisboa Centro de Química Estrutural, Portugal

Sorbonne Université, France
2017 - 2018 Novel tacrine-benzofuran hybrids as potential drugs for Alzheimer´s disease
Co-supervisor
Università degli Studi di Pisa, Italy

Universidade de Lisboa Centro de Química Estrutural, Portugal
2017/07/10 - 2017/07/14 Determinação da actividade inibitória enzimática de compostos anti-neurodegenerativos
Supervisor
 EstVerDEQ 2017 (Scientific initiation)
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2017 - 2017 Tacrine derivatives as potential multifunctional drugs against Alzheimer´s disease- physicochemical and biological properties
Co-supervisor
 Química (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 Suporte sólido funcionalizado com hidroxiquinolina para remoção de metais em meios aquáticos
Supervisor
 Engenharia do Ambiente (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/07 - 2016/09 Hybrid compounds as anti-Alzheimer´s disease agentes
Co-supervisor
 ERASMUS+ (Scientific initiation)
Universidade de Lisboa Centro de Química Estrutural, Portugal

Yildiz Teknik Üniversitesi, Turkey
2016/07/01 - 2016/07/30 Evaluation of multifunctional compounds as anti-neurodegenerative drugs
Supervisor
Universidade de Lisboa Centro de Química Estrutural, Portugal

Sorbonne Université Campus Pierre et Marie Curie, France
2015/09 - 2015/12 Combined roles of zinc-binding groups and sulfur oxidation state to drive potency and selectivity in thioaryl-based inhibitors of MMPs
Co-supervisor
Università degli Studi di Pisa, Italy

Universidade de Lisboa Centro de Química Estrutural, Portugal
2014 - 2015 Physico-chemical studies for characterization of complexes with some dyes
Co-supervisor
Universidade de Lisboa Instituto Superior Técnico, Portugal

South Valley University Faculty of Science, Egypt
2014/05 - 2014/07 Physicochemical characterization of copper(II) complexes by potentiometry, 1H NMR and UV-Vis
Supervisor
 Estágio em técnicas potenciométricas e espectroscópicas (Specialization course)
Universidade de Lisboa Centro de Química Estrutural, Portugal

University Jan Kochanowski, Poland
2001 - 2009 Novos Sistemas Quelantes do tipo Hidroxipirimidinona. Imobilização em suportes sólidos e inibição enzimática
Co-supervisor
Laboratório Nacional de Energia e Geologia - Campus do Lumiar, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
2002 - 2007 Novos Inibidores de Metaloproteinases de Matriz e Anidrases Carbónicas: Síntese, Estudos de Inibição e de Complexação
Co-supervisor
 Química (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2012/06/18 - 2012/06/22 Organização (Co-Chairperson) do International Symposium om Metal Complexes, ISMEC 2012, Fundação Calouste Gulbenkian, Lisboa, Portugal. http://ismec2012.ist.utl.pt/ (2012/06/18 - 2012/06/22)
Congress (Member of the Organising Committee)
 Universidade de Lisboa Instituto Superior Técnico, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/05/23 - 2022/05/23 Química Orgânica e Química Analítica, visitas a Laboratórios e Museus do DEQ
Workshop
Instituto Superior Técnico Departamento de Engenharia Química, Portugal
2022/05/09 - 2022/05/13 Os Metais: essenciais ou tóxicos?
Workshop
 Laboratórios Abertos 2022 do DEQ
Instituto Superior Técnico Departamento de Engenharia Química, Portugal
2020/02/03 - 2020/02/07 VER Química
Workshop
 Laboratórios Abertos 2020 do DEQ
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2020/01 - 2020/01 Doseamento de Na e K em amostras de água por fotometria de chama de emissão
Workshop
 Projecto de alunos de Química (12º ano) do Agrupamento de Escolas de Paço de Arcos
Universidade de Lisboa Departamento de Engenharia Química, Portugal

Agrupamento de escolas de Paço de Arcos, Portugal
2019/04 - 2019/04 Doseamento de ferro em amostras de água por espectrofotometria UV/Vis
Workshop
 Projecto de alunos de Química (12º ano) da Escola Secundária da Azambuja
Universidade de Lisboa Departamento de Engenharia Química, Portugal

Agrupamento escolas Azambuja, Portugal
2019/02/04 - 2019/02/09 Cu: um metal de transição ISBN:978-989-99508-6-3
Workshop
 Laboratórios Abertos 2019 do DEQ
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2018/04 - 2018/04 Aula integrada no projecto “O efeito dos fogos florestais e da seca na produção e qualidade do mel no nosso país”
Workshop
 Concurso Jovens Cientistas - alunos de Química (12º ano) Escola Secundária da Azambuja
Universidade de Lisboa Departamento de Engenharia Química, Portugal

Agrupamento escolas Azambuja, Portugal
2018/02/05 - 2018/02/09 Let´s take…a drink! ISBN: 978-989-99508-5-6
Workshop
 Laboratórios Abertos 2018 do DEQ
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2017/02/06 - 2017/02/10 Doce Química ISBN: 978-989-99508-4-9
Workshop
 Laboratórios Abertos 2017 do DEQ
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2016/02/02 - 2016/02/04 Química Forense & Toxicologia ISBN: 978-989-99508-3-2
Workshop
 Laboratórios Abertos 2016 do DEQ
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2015/02/02 - 2015/02/06 Acidificantes ou…refrigerantes? ISBN: 978-989-99508-2-5
Workshop
 Laboratórios Abertos 2015 do DEQ
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2014/02/03 - 2014/02/07 Química do Supermercado ISBN: 978-989-96933-8-8
Workshop
 Laboratórios Abertos 2014 do DEQ
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2013/02/04 - 2013/02/08 Química dos Cosméticos ISBN: 978-989-96933-7-1
Workshop
 Laboratórios Abertos 2013 do DEQ
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2012/02/06 - 2012/02/10 Química e Crime ISBN: 978-989-96933-3-3
Workshop
 Laboratórios Abertos 2012 do DEQ
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2011/02/14 - 2011/02/18 Luz e Cor…talvez Química ISBN: 978-989-96933-2-6
Workshop
 Laboratórios Abertos 2011 do DEQB
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2011/02/14 - 2011/02/18 A Paleta Química das Cores ISBN: 978-989-96933-1-9
Workshop
 Laboratórios Abertos Júnior 2011 do DEQB
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2010/02/18 - 2010/02/24 Química em Acção! ISBN: 978-989-96933-0-2
Workshop
 Laboratórios Abertos 2010 do DEQB
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2009/02/16 - 2009/02/20 Sub-módulos “Análises Químicas” e “Triboluminescência e fluorescência”
Workshop
 Laboratórios Abertos 2009 do DEQB
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2008/02/18 - 2008/02/22 Análises químicas, para quê?
Workshop
 Laboratórios Abertos 2008 do DEQB
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2007/02/05 - 2007/02/16 Química do Supermercado
Workshop
 Laboratórios Abertos 2007 do DEQB
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2006/03/23 - 2006/03/23 Módulo de Química Forense na acção *Seja investigador por um dia*
Workshop
 “Seja investigador por um dia”, Acção para jornalistas 2006 do DEQB
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2006/02/06 - 2006/02/17 Química colorida – Química Forense
Workshop
 Laboratórios Abertos 2006 do DEQB (actividade de divulgação das áreas de intervenção do DEQ)
Universidade de Lisboa Departamento de Engenharia Química, Portugal
2005/02/18 - 2005/02/23 Laboratórios Abertos 2005 do DEQ (actividade de divulgação das áreas de intervenção do DEQ)
Workshop
 Laboratórios Abertos 2005 do DEQ
Universidade de Lisboa Departamento de Engenharia Química, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2009/06 Novos sistemas quelantes do tipo hidroxipirimidinona. Imobilização em suportes sólidos e inibição enzimática
Thesis Member
 Anabela Rodrigues Capelo (PhD)
Instituto Superior Técnico Departamento de Engenharia Química, Portugal
2007/07 Novos Inibidores de Metaloproteinases de Matriz e Anidrases Carbónicas: Síntese, Estudos de Inibição e de Complexação
Thesis Member
 Sérgio Manuel Marques (PhD)
Instituto Superior Técnico Departamento de Engenharia Química, Portugal
2006/12 Derivados peptídicos e não peptídicos de 3-hidroxi-2-metilpiridin-4(1H)-onas: síntese, interacção com iões metálicos e estudos biológicos
(Thesis) Arguer
 Marco António Dias de Sousa Gil (PhD)
Instituto Superior Técnico Departamento de Engenharia Química, Portugal
2006/04 Sistemas Moleculares do Tipo Poli-Hidroxipiridinonato com Potencial Aplicação Terapêutica /Ambiental: Síntese, Interacção com Metais e Estudos Biológicos
Thesis Member
 Raquel Eliana Lourenço Grazina (PhD)
Instituto Superior Técnico Departamento de Engenharia Química, Portugal

Interview (tv / radio show)

Program Topic
2021/05/16 - 2021/05/16 Hora da Verdade, TVI O perigo de utilizar uma mistura de lixívias
2021/05/02 - 2021/05/02 Hora da Verdade, TVI A utilização de bicarbonato de sódio na lavagem de roupa
2021/03/19 - 2021/03/19 Hora da Verdade, TVI O mito da explosão mentos + Coca-Cola