Cláudia Maria Fragão Pereira (6A1D-22C8-B2A3)

Curriculum Vitae

Cláudia Maria Fragão Pereira

C Pereira is Biochemist, Master in Cell Biology and received, in 2000, her PhD in Cell Biology from the Faculty of Sciences and Technology, University of Coimbra (UC), Portugal. Presently, she is Principal Investigator (with tenure) at the Faculty of Medicine from UC (FMUC), and is Principal Investigator (PI) of the research line Endoplasmic Reticulum (ER) Stress Response and ER-Mitochondria Axis at the Cell Signaling and Metabolism group from the Center for Neuroscience and Cell Biology (CNC), which integrates the Center for Innovative Biomedicine and Biotechnology (CIBB) at UC, recently renewed the Associated Laboratory status with a top 100% score. The specific aims of her research line are to: 1) clarify the biological basis of neuropsychiatric diseases, namely neurodegenerative disorders such as Alzheimer dementia and mental disorders like bipolar disorder and schizophrenia, focusing on the deregulation of cellular stress responses, with a special focus on ER and mitochondria stress, and its metabolic and immune implications; 2) explore novel preventive and therapeutic options, namely the potential of natural resources. For these purposes, both in vitro (cell lines and primary cell cultures) and in vivo experimental models (transgenic mice) and also human biological samples (blood samples and skin-derived fibroblasts) are used due to a long-lasting and fruitful collaboration with the Neurology and Psychiatry Departments from the Coimbra University Hospital (CHUC). Due to participation in several funded projects, either as PI/co-PI or as team member, C Pereira published more than 90 peer-reviewed papers, the majority in international quartile 1 (Q1) journals. In addition, she is inventor of 1 patent and 5 presently under evaluation, demonstrating the relevance of her research in knowledge transfer promotion and economic valorization. The scientific impact of her research is reflected in the H index (39) and high nº of citations (~ 4500) (WoScc). In 2004 C Pereira was awarded with the LOréal For Women in Science Prize (1st edition). Until 2022, she integrated the Evaluation Board of this L'Oréal Portugal/UNESCO/FCT award and was invited to participate in the 2021 edition of "Women in Science " book that brings together portraits of Portuguese female researchers. She supervised several PhD (8 concluded, 2 ongoing) and Master (>20 concluded) students, research fellows, UC 1st cycle and ERASMUS students. She is actively enrolled in Master and PhD programs at UC as lecturer or member of organizing committee, thesis supervision, thesis evaluation board (Evaluator, President or Vogal). In addition, she teaches (1st cycle) since 2008: integrated masters in Medicine and Biomedical Engineering (UC), Physiotherapy course (Coimbra Health Technologies School). She is Editor of scientific journals as well as reviewer for J Neurosci, Cell Death Diff, Free Radic Biol Med, Neurobiol Aging, among many others, and has integrated the evaluation board of funding agencies such as ARS (France) and FCT (Portugal). She was invited speaker and/or co-authored more than 50 oral and 100 poster communications in (inter)national scientific meetings and was also enrolled in the organization of several scientific meetings. She actively participated in several science outreach projects and activities, namely "Ciencia Viva during Summer Holidays" and "Brain Awareness Week", and was invited to participate in events in media and broad end-users (TV, radio, newspapers, social networks). In addition to research and teaching duties, C Pereira is also enrolled in FMUC management as member of the Faculty Assembly and of ORBEA the animal welfare entity, and is presently member of the Board of Directors of CNC-UC, . C Pereira is volunteer at the "Machado de Castro" Museum (Coimbra, Portugal) in the project "EU no MusEU" (collaboration with the Alzheimer Portugal Association).

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Identification

Personal identification

Full name: Cláudia Maria Fragão Pereira

Citation names

Pereira, Cláudia
Pereira, Cláudia Fragão
Pereira, Cláudia Maria Fragão

Author identifiers

Ciência ID: 6A1D-22C8-B2A3
ORCID iD: 0000-0002-6630-5056
Researcher Id: A-6506-2013
Scopus Author Id: 24473095000

Email addresses

cpereira@fmed.uc.pt (Professional)
cpereira@cnc.uc.pt (Professional)

Telephones

Fax

239822776 (Professional)

Telephone

239820190 (Professional)

Addresses

Faculty of Medicine, Polo III, University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-354, Coimbra, Coimbra, Portugal (Professional)
Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Faculty of Medicine, Polo I, 1st floor, 3004-504, Coimbra, Coimbra, Portugal (Professional)
Center for Innovative Biotechnology and Biomedicine (CIBB), 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

---http://www.cnbc.pt/research/department_group_show.asp?iddep=1138&idgrp=1142 (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
1995 - 2000/12/15 Concluded	PhD in Biology (Doutoramento) Major in Cell Biology Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Mechanisms of cellular degeneration in two models of oxidative stress induced glutamate and beta-amyloid protein. Implications for the etiopathogenesis of Alzheimer's disease" (THESIS/DISSERTATION)	Approved with distinction and honor by unanimity
1992 - 1994 Concluded	Master in Cell Biology (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Effect of lipid peroxidation in the mitochondrial respiratory activity and mechanisms calcium regulation in synaptosomes" (THESIS/DISSERTATION)	Muito bom
1987/09 - 1991/07 Concluded	BSci Biochemistry (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "n.a." (THESIS/DISSERTATION)	Bom:15 (20) valores

Affiliation

Science

	Category Host institution	Employer
2024/02/05 - Current	Principal Investigator (Research)	Universidade de Coimbra Faculdade de Medicina, Portugal
	Universidade de Coimbra Faculdade de Medicina, Portugal
2000/12/16 - Current	Auxiliary Researcher (Research)	Universidade de Coimbra Faculdade de Medicina, Portugal
	Universidade de Coimbra Faculdade de Medicina, Portugal
2000 - Current	Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1999/12/30 - 2000/12/15	Research Assistant (Research)	Universidade de Coimbra Faculdade de Medicina, Portugal
	Universidade de Coimbra Faculdade de Medicina, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2008 - Current	Invited Teacher Coordinator (Polytechnic Teacher)	Universidade de Coimbra Faculdade de Medicina, Portugal
	Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Positions / Appointments

	Category Host institution	Employer
2023 - Current	Membro da Direção CNC-UC	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra, Portugal
2019/03/01 - Current	Assembly Member	Universidade de Coimbra Faculdade de Medicina, Portugal

2020/10 - 2022/09	Membro da Direção CNC-EPSFL	Universidade de Coimbra, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Projects

Grant

	Designation	Funders
2020/02/01 - 2024	Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism SFRH/BD/148801/2019 Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
1995 - 1998	Mecanismos de degenerescência celular em dois modelos de stress oxidativo induzido por glutamato e pela proteína beta-amilóide. Implicações para a etiopatogenia da doença de Alzheimer BD/3889/94 PhD Student Fellow Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1992 - 1993	Efeito da peroxidação lipídica na actividade respiratória mitocondrial e nos mecanismos de regulação do cálcio em sinaptossomas BM/1444/91-ID Master Student Fellow Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2019 - Current	Impact of the action of natural products on human innate immune and tumor cells 88887.194785/2018-00 Researcher Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Botucatu, Brazil	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Ongoing
2023/05/01 - 2027/04/30	De-risking metabolic, environmental and behavioral determinants of obesity in children, adolescents and young adults (PAS GRAS) na 10.3030/101080329 Researcher Universidade de Coimbra, Portugal	Horizon 2020 Ongoing
2020/01 - 2026/12	MIA-Portugal 857524 Researcher Universidade de Coimbra, Portugal	Horizon 2020 Ongoing
2023/05/01 - 2024/04/30	Deciphering the key events of micro- and nanoplastics toxicity triggered in skin to establish the adverse outcome pathway (AOP) Sem código Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Laboratoires Vichy Ongoing
2021/07/08 - 2022/12/31	ValSar: Valorização do Sargaço da Costa Litoral Norte MAR-04.03.01-FEAMP-0502 MAR2020 Researcher Universidade de Coimbra, Portugal	Ongoing
2018/07/26 - 2022/07/25	The ups and downs of cellular stress. the "MAM" hypothesis for Bipolar disorder pathophysiology CENTRO-01-0145-FEDER-028214 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/26 - 2022/07/25	Os altos e baixos do stresse celular: a "hipótese MAM" para a patofisiologia da doença Bipolar PTDC/MED-NEU/28214/2017 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/09 - 2022/03/31	Doença Bipolar - Um outro lado #385-PCC2021 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Ongoing
2019 - 2021	Saude no Saber 45-2019/478 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Ciência Viva Ongoing
2018 - 2021	Skin allergens: molecules with an improbable therapeutic application for Alzheimer’s disease CENTRO-01-0145-FEDER-029369 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018 - 2021	InPaCTus COMPETE 21874 COMPETE2020 nº 21874 Principal investigator Universidade de Coimbra, Portugal	Agência Nacional de Inovação SA Ongoing
2016/04/01 - 2019/06/30	Drugs2CAD CENTRO-01-0247- FEDER-003269 Researcher Universidade de Coimbra, Portugal	European Regional Development Fund Concluded
2017 - 2018	Valorization of the thermal resorts of the Centre Region- characterization of the bioactive potential of the thermal water resources of the region: study of the therapeutic potential of thermal waters- dermocosmetic CENTRO-04-3928-FEDER-000010 Researcher Universidade de Coimbra, Portugal	Horizon 2020 Framework Programme Concluded
2017 - 2018	New BACE1 inhibitors for the treatment of Alzheimer's disease: an approach for the development of effective and safe substrate-selective inhibitors EDGAR CRUZ SILVA 2017 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação Edgar Cruz e Silva Concluded
2013/06/15 - 2015/11/30	Tratamento da doença de Alzheimer com um novo peptídeo inibidor da BACE1 PTDC/NEU-SCC/1351/2012 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014 - 2015	Diagnóstico y combate molecular de tres enfermedades neurodegenerativas (Parkinson, fenilcetonuria y amiloidosis TTR) NEUROMED Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	European Commission Seventh Framework Programme for Research and Technological Development Concluded
2013 - 2015	Tackling Alzheimers disease with a new peptide inhibitor of BACE1 PTDC/NEU-SCC/1351/2012 Researcher Fundação para a Ciência e a Tecnologia, Portugal	Concluded
2010/06/01 - 2013/06/30	Perfis dinâmicos do óxido nítrico no cérebro: regulação da respiração celular com implicações para a doença de Alzheimer e para o envelhecimento PTDC/SAU-NEU/103538/2008 Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2013/06/30	Derivados de Benzazolo Marcados com Fluor-18 e Tecnécio-99m para Visualização In Vivo de Depósitos de Amilóide PTDC/QUI-QUI/102049/2008 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2013	Influence of cell age and CX3CL1/CX3CR1 signaling on microglial-neuronal dialogue in Alzheimer’s disease pathogenesis EDGAR CRUZ SILVA 2012 Researcher Universidade de Lisboa Faculdade de Farmácia, Portugal	Fundação Edgar Cruz e Silva Concluded
2011/01/01 - 2012/12/31	Strategic Project - LA 1 - 2011-2012 PEst-C/SAU/LA0001/2011 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2012	Amyloid-beta-sensitized dendritic cells as Alzheimer's disease vaccine 01CP11 Principal investigator Universidade de Coimbra Faculdade de Medicina, Portugal	Universidade de Coimbra Faculdade de Medicina Concluded
2011 - 2012	Crosstalk between endoplasmic reticulum and mitochondria in diabetes-related neurodegeneration: bringing bedside problems to the bench 02CP11 Principal investigator Universidade de Coimbra Faculdade de Medicina, Portugal	Universidade de Coimbra Faculdade de Medicina Concluded
2010 - 2012	Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation PTDC/QUI-QUI/102049/2008 Researcher Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010 - 2012	In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging PTDC/SAU-NEU/103538/2008 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010 - 2012	The pathological interaction between diabetes and Alzheimer’s disease: exploring the role of brain endothelial mitochondria and uncoupling proteins PTDC/SAU-NEU/103325/2008 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2010	Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer’s disease PTDC/SAU-NEU/71675/2006 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2010	Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools PIC/IC/83206/2007 Researcher Hospitais da Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2010	Towards novel inhibitors of Alzheimer's disease-associated beta-amyloid aggregation and toxicity: from statins as potential leads to the design of effective drugs III/40/2008 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Universidade de Coimbra Instituto de Investigação Interdisciplinar Concluded
2007 - 2007	Let’s study the brain: neuroscientists at school and schools at neuroscience laboratories BAW2007 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluded
2005 - 2007	Signaling pathways involved in the cross-talk between alpha-synuclein and beta-amyloid proteins in Alzheimer’s disease neurodegeneration III_CP2005 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Universidade de Coimbra Instituto de Investigação Interdisciplinar Concluded
1999 - 2003	A comparative study of the neurotoxic mechanisms of prion and amyloid-beta peptides. Potential neuroprotective strategies POCTI/1999/NSE/36101 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2014/03/01 - Current	Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing info:eu-repo/grantAgreement/FCT/3599-PPCDTI/135805/PT	Universidade do Algarve Faculdade de Ciências e Tecnologia Concluded
2017/01/01 - 2020/12/31	HealthyAging2020 CENTRO-01-0145-FEDER-000012 Researcher Universidade de Coimbra, Portugal	EU Framework Programme for Research and Innovation Excellent Science Ongoing
2013 - 2014	Faulty cross-talk between endothelial cells and neurons in Alzheimer´s disease brain. Does endoplasmic reticulum stress play a role? GAI 2014 Researcher Universidade de Coimbra Faculdade de Medicina, Portugal	Universidade de Coimbra Faculdade de Medicina Concluded
2013 - 2014	How does autophagy modulate inflammasome activation? GAI 2014_2 Principal investigator Universidade de Coimbra Faculdade de Medicina, Portugal	Universidade de Coimbra Faculdade de Medicina Concluded
2007 - 2013	New strategies to manage brain diseases CENTRO-07-ST24-FEDER-002002 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	EU Framework Programme for Research and Innovation Excellent Science Concluded
2007 - 2013	Aging, stress and chronic diseases: from mechanisms to therapeutics CENTRO-07-ST24-FEDER-002006 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	EU Framework Programme for Research and Innovation Excellent Science Concluded
2009 - 2011	Phosphorylation and oxidation of NMDA receptor subunits in Alzheimer’s disease and protective role of memantine LUNDBECK2009 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Lundbeck Portugal Concluded
2004 - 2005	Cross-talk” between mitochondria and endoplasmic reticulum in Alzheimer’s disease. Studies with cybrids FOE WOMEN IN SCIENCE 2004 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Pereira, Cláudia; Catarina Resende de Oliveira. "Envelhecimento cerebral e doença de Alzheimer". In Neurociências, edited by Rego, Ana Cristina; Bandeira-Duarte, Carlos; Catarina Resende de Oliveira, 1-740. Portugal: LIDEL, 2017. Published Pereira, Cláudia; Resende, Rosa; Resende de Oliveira, Catarina; Resende, R.; Oliveira, C.R.; Pereira, C.M.F.. "Role of glycogen synthase kinase-3beta on tau phosphorylation in Alzheimer’s disease". In Advances in Medicine and Biology, edited by Leon V. Berhardt, 197-210. Nova Science Publishers, 2010. Published Pereira, Cláudia. "Epigenetics and neurodegeneration: a connection overlooked.". In Epigenetics: Mechanisms, Functions and Human Effects, edited by Balázs Pintér; Zsolt Mészáros. Nova Science Publishers, 2010. Elisabete Ferreiro; Costa RO; Sueli Marques; Catarina Resende de oliveira; Pereira, Cláudia Maria Pereira. "ROLE OF ENDOPLASMIC RETICULUM-MEDIATED APOPTOTIC PATHWAY IN Ab TOXICITY". In Cognitive Sciences at the leading Edge, 67-82. NY, United States: Nova Science Publishers, Inc.,, 2008. Published Pereira, Cláudia; Grazina, Manuela; Catarina Resende de Oliveira. "ß-Amyloid protein impairs mitochondrial function". In Mitochondrial ubiquinone (coenzyme Q10): biochemical, functional, medical and therapeutic aspects in human health and diseases, edited by Manuchair S Ebadi, 282-300. Prominent Press, 2001.
Conference abstract	Resende, Rosa; Ferreira-Marques, Marisa; Dinis, Teresa; Pereira, Cláudia; Santos, Armanda. "New BACE1 inhibitors decrease Aß production in cellular and in vivo models of Alzheimer's disease". Paper presented in 30ª Reunião do Grupo de Estudos do Envelhecimento Cerebral e Demência, Lisbon, 2016. Published Sousa, Cátia; Leitão, Alcino Jorge; Silva, Maria M. C.; Pereira, Cláudia Fragão; Sá e Melo, Maria Luísa. "Estradiol as a scaffold to generate molecular diversity and to develop neuroprotective agents". Paper presented in 2nd Portuguese Meeting on Medicinal Chemistry, Coimbra, 2010. Resende, Rosa; Moreira, Paula Isabel; Deshpande, Atul; Busciglio, Jorge; Pereira, Cláudia Fragão; Oliveira, Catarina R. "Increased oxidative stress is an early pathological feature in 3xTg-AD mice.". Paper presented in Alzheimer's Association International Conference on Alzheimer's Disease (ICAD), Chicago, 2008. Published • 10.1016/j.jalz.2008.05.2250
Conference poster	Moreira, Patricia; Macedo, Jéssica; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Silva, Sónia; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Neuroprotective properties of extracts from Eucalyptus globulus biomass and its beneficial effects in an Alzheimer's disease mouse model". Paper presented in 16th International Conference on Alzheimer's & Parkinson's Diseases, Barcelona, Spain, 2022. Silva, Ana Cristina Rosa da; Pereira, Marta; Carrascal, Mylene; Brites, Gonçalo Sousa; Neves, Bruno; Moreira, Patricia; Resende, Rosa; et al. "EFFECT OF SKIN ALLERGENS TARGETING NRF2 TRANSCRIPTION FACTOR ACTIVATION ON ALZHEIMER¿S DISEASE HALMARKS". Paper presented in 15th International Conference on Alzheimer's and Parkinson's Diseases (ADPD2021), 2021. Moreira, Patricia; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Silva, Sónia; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Effects of extracts from forestry biomass in Alzheimer's disease in vitro and in vivo models: interplay between bioeconomy and health benefits". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal, 2021. Moreira, Patricia; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Chemical composition and bioactivity of phenolic compounds extracted from Eucalyptus globulus biomass". Paper presented in IberPhenol - International Conference, Coimbra, Portugal, 2020. Sousa, Fábio J.; Carrascal, Myléne A.; Moreira, Paula I.; Santos, Armanda E.; Cruz, Maria Teresa; Pereira, Cláudia. "Impact of Endoplasmic Reticulum stress on neuronal mitochondria". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, Coimbra, Portugal, 2019. Moreira, Patricia; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Antifungal activity and cytotoxicity evaluation of phenolic compounds extracted from Eucalyptus globulus biomass". Paper presented in Iberian Congress of Phenolic Compounds, Ourense, Spain, 2019. Silva, Ana; Pereira, Marta; Brites, Gonçalo; Neves, Bruno; Moreira, Patricia; Resende, Rosa; Silva, Maria Manuel; et al. "Skin allergens and Alzheimer´s disease: preliminary studies on an (im)probable link". Paper presented in Cell Signalingin Aging and Neurodegenerative Diseases, Coimbra, Portugal, 2019. Moreira, Patricia; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Determination of safe bioactive doses of essential oil and phenolic compounds extracted from Eucalyptus globulus leaves". Paper presented in Natural Products in Drug Discovery and Human Health (NatProdDDH) ¿ PSE Meeting, Lisbon, Portugal, 2019. Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Morais, S; Madeira, N; Cruz, Maria Teresa; Pereira, Cláudia. "Mitochondria-Associated Membranes: the putative link between cellular stress and inflammasome activation in Bipolar Disorder". Paper presented in Encontro Nacional da Sociedade Portuguesa de Psiquiatria e Saúde Mental (SPPSM)\| II Encontro das Secções, 2019. Pereira, Marta; Silva, Ana; Neves, Bruno; Moreira, Patricia; Silva, Maria Manuel; Santos, Armanda Emanuela; Pereira, Cláudia Fragão; Cruz, Maria Teresa. "Molecules with an improbable therapeutic application for Alzheimer¿s disease". Paper presented in Ageing: models, mechanisms and therapies, Coimbra, Portugal, 2019. Resende, Rosa; Moreira, Patricia; Ferreira-Marques, Marisa; Dinis, Teresa; Oliveira, Francisco; Sereno, José; Abrunhosa, Antero; et al. "New chimeric peptides selectively inhibit APPß cleavage decreasing Aß formation and accumulation in AD models". Paper presented in 14th International Conference on Alzheimer's & Parkinson's Diseases, Lisbon, Portugal, 2019. Silva, Ana Cristina Rosa da; Pereira, Marta; Brites, Gonçalo Sousa; Neves, Bruno; Moreira, Patricia; Resende, Rosa; Silva, MMC; et al. "Skin allergens and Alzheimer´s disease: preliminar studies on na (im)probable link". Paper presented in . 8th ECS workshop Calcium Signalin in Aging and Neurodegenerative Diseases, 2019. Sousa, Fábio J.; Carrascal, Mylene; Moreira, Paula Isabel; Santos, Armanda E; Cruz, Maria Teresa; Pereira, Cláudia. "Impact of ER stress on neuronal mitochondria". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019. Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Madeira, N; Cruz, Maria Teresa; Pereira, Cláudia. "Resposta ao stresse celular em células do sistema imune inato na doença Bipolar". Paper presented in 2º Semina´rio da Sociedade Portuguesa para o Estudo da Saúde Mental - SPESM, 2018. Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Cruz, Maria Teresa; Pereira, Cláudia. "Role of Mitochondria-Associated Membranes in the endoplasmic reticulum stress response in the innate immune system". Paper presented in MitoPorto International Symposium, 2018. Cardoso, R; Almeida, Maria Rosário; Baldeiras, Inês; Pereira, Cláudia Fragão; Oliveiros, Bárbara; Santana, Isabel; Oliveira, Catarina Resende. "Association between TOMM40 poly-T repeat variants and risk of mild cognitive impairment conversion to Alzheime's disease". Paper presented in 21st Annual Meeting -Sociedade Portuguesa de Genética Humana, 2017. Resende, Rosa; Ferreira-Marques, Marisa; Dinis, Teresa; Oliveira, F; Sereno, J; Abrunhosa, Antero; Castelo-Branco, Miguel; Pereira, Cláudia; Santos, Armanda E. "New BACE1 inhibitors decrease Aß production and accumulation in the 3xTg-AD mouse model". Paper presented in 13th International Conference on Alzheimer¿s & Parkinson Diseases, 2017. Ferreira-Marques, Marisa; Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda E. "Tackling Alzheimer´s disease with a new inhibitor of BACE1: evaluation of peptide efficiency in vitro and in an in vivo model of AD". Paper presented in XIV Meeting of the Portuguese Society for Neurosciences, 2015. Ferreira-Marques, Marisa; Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda E. "New BACE1 inhibitors for Alzheimer´s disease treatment.". Paper presented in 19th European Synposium on Organyc Chemistry (ESOC 2015), 2015. Ferreira-Marques, Marisa; Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda. "Tackling Alzheimer's disease with a new inhibitor of BACE1: evaluation of compound efficacy in vitro and in a cellular model of Alzheimer's disease". Paper presented in XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal, 2014. Ferreira-Marques, Marisa; Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda E. "Tackling Alzheimer´s disease with a new inhibitor of BACE1: evaluation of compound efficacy in vitro and in a celular model of AD". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014. Ferreira, I.L.; Ferreiro, Elisabete; Mota, S.I.; Cardoso, J.M.; Pereira, Cláudia Maria Pereira; Oliveira, C.R.; Rego, Ana Cristina. "In situ mitochondrial dysfunction evoked by immediate exposure to amyloid-beta 1-42 and NMDA receptor activation involving calcium release from endoplasmic reticulum". Paper presented in XIII Annual Meeting of the Portuguese Society for Neurosciences, 2013. Mota, S.I.; Costa, R.O.; Caldeira, G.L.; Santana, Isabel; Padovano, C.; Fonseca, A.C.; Letra, Liliana; et al. "Oxidative and endoplasmic reticulum stress in early stages of Alzheimer¿s disease". Paper presented in X CNC Annual Meeting, 2012. Mota, S.I.; Costa, R.O.; Caldeira, G.L.; Santana, Isabel; Padovano, C.; Fonseca, A.C.; Letra, Liliana; et al. "Nrf2 downregulation-mediated oxidative stress and ER stress in early stages of Alzheimer¿s disease". Paper presented in Meeting Cold Spring Harbor- New York, United States, 2012. Mota, S.I.; Ferreira, I.L.; Ferreiro, Elisabete; Pereira, Cláudia Maria Pereira; Oliveira, C.R.; Rego, Ana Cristina. "Age and gender-dependent modifications in NMDA receptor subunits in the cortex and hippocampus of Alzheimer¿s disease transgenic mice". Paper presented in 8th FENS Forum of Neuroscience, 2012. Mota, S.I.; Costa, R.O; Santana, Isabel; Padovano, C; Fonseca, A.C.; Caldeira, G.L.; Letra, Liliana; et al. "Changes in oxidative and endoplasmic reticulum stress in human peripheral blood mononuclear cells during early stages of Alzheimer¿s disease". Paper presented in 26ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, 2012. Rego, Ana Cristina; Mota, S.I.; Ferreira, I.L.; Oliveira, C.R.; Pereira, Cláudia Maria Pereira. "Age-dependent NMDA receptor subunit composition and activation in Alzheimer¿s disease females and males 3xTg-AD mice". Paper presented in XII Meeting of the Portuguese Neuroscience Society, 2011. Mota, S.I.; Ferreira, I.L.; Pereira, Cláudia Maria Pereira; Oliveira, C.R.; Rego, Ana Cristina. "Brain cortical changes in NMDA receptor subunit expression and activation in Alzheimer¿s disease". Paper presented in SINAL2011, 5th Annual Meeting on Cell Signalling, 2011. 10.1109/nanomed.2013.6766320 Fonseca, A.C.; Ferreira, I.L.; Costa, R.O.; Mota, S.I.; Padovano, C; Letra, Liliana; Oliveira, C.R.; et al. "Increased susceptibility to cell death following early peripheral endoplasmic reticulum and oxidative stress in Alzheimer¿s disease patients". Paper presented in SINAL2011, 5th Annual Meeting on Cell Signalling, 2011. Rego, Ana Cristina; Ferreira, I.L.; Mota, S.I.; Bajouco, Miguel; Pereira, Cláudia Maria Pereira; Oliveira, C.R.. "Early intracellular calcium deregulation and microtubule disassembly induced by amyloid-beta 1-42 oligomers in primary cultured neurons role of NR2B receptor subunit". Paper presented in 7th FENS Forum of European Neuroscience, 2010. Mota, S.I.; Ferreira, I.L.; Oliveira, C.R.; Pereira, Cláudia Maria Pereira; Rego, Ana Cristina. "Alzheimer¿s disease-associated amyloid-beta petide induces microtubule disassembly and DNA fragmentation in mature hippocampal neurons". Paper presented in Ciência 2010, 2010. Ferreira, IL; Mota, S.I.; Bajouco, Miguel; Pereira, Cláudia Fragão; Oliveira, C.R.; Rego, Ana Cristina. "Role of NMDA receptor subunits NR2A and NR2B on neuronal dysfunction caused by oligomeric amyloid-beta peptide". Paper presented in Sociedade Portuguesa de Neurociências, 2009.
Journal article	Tânia Fernandes; Tânia Melo; Tiago Conde; Bruna Neves; Pedro Domingues; Rosa Resende; Cláudia F. Pereira; Paula I. Moreira; Maria Rosário Domingues. "Mapping the lipidome in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer's disease". Journal of Neurochemistry (2024): https://doi.org/10.1111/jnc.16072. 10.1111/jnc.16072 Jorge M. Alves-Silva; Patrícia Moreira; Carlos Cavaleiro; Cláudia Pereira; Maria Teresa Cruz; Lígia Salgueiro. "Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging". Plants (2023): https://doi.org/10.3390/plants12213741. 10.3390/plants12213741 Cátia. S. D. Oliveira; Patrícia Moreira; Maria T. Cruz; Cláudia M. F. Pereira; Artur M. S. Silva; Sónia A. O. Santos; Armando J. D. Silvestre. "Exploiting the Integrated Valorization of Eucalyptus globulus Leaves: Chemical Composition and Biological Potential of the Lipophilic Fraction before and after Hydrodistillation". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24076226. 10.3390/ijms24076226 Tânia Fernandes; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira. "A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases". Biology (2023): https://doi.org/10.3390/biology12030414. 10.3390/biology12030414 Cátia S. D. Oliveira; Patrícia Moreira; Maria T. Cruz; Cláudia M. F. Pereira; Alexandre Gaspar; Carlos Pascoal Neto; Paula C. R. O. Pinto; et al. "An integrated green process for the extraction of triterpenic acids from Eucalyptus globulus leaves after hydrodistillation". RSC Sustainability (2023): https://doi.org/10.1039/D3SU00076A. 10.1039/D3SU00076A Patrícia Moreira; Patrícia Matos; Artur Figueirinha; Lígia Salgueiro; Maria Teresa Batista; Pedro Costa Branco; Maria Teresa Cruz; Cláudia Fragão Pereira. "Forest Biomass as a Promising Source of Bioactive Essential Oil and Phenolic Compounds for Alzheimer’s Disease Therapy". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23158812. 10.3390/ijms23158812 Sunil Chikkalakshmipura Gurumallu; Tareq N. AlRamadneh; Halugudde Nagaraja Sarjan; Ashwini Bhaskar; Cláudia Maria Fragão Pereira; Rajesha Javaraiah. "Synergistic hypoglycemic and hypolipidemic effects of ¿-3 and ¿-6 fatty acids from Indian flax and sesame seed oils in streptozotocin-induced diabetic rats". Phytomedicine Plus (2022): https://doi.org/10.1016/j.phyplu.2022.100284. 10.1016/j.phyplu.2022.100284 Resende, Rosa; Fernandes, Tânia; Pereira, Ana Catarina; Marques, Ana Patrícia; Pereira, Cláudia Fragão. "ER-Mitochondria contacts modulate ROS-mediated signaling and oxidative stress in brain disorders: the key role of Sigma-1 receptor.". Antioxidants & Redox Signaling (2022): http://dx.doi.org/10.1089/ars.2020.8231. Published • 10.1089/ars.2020.8231 Conte, Fernanda Lopes; Pereira, Ana Catarina; Brites, Gonçalo; Ferreira, Isabel; Silva, Ana Cristina; Sebastião, Ana Isabel; Matos, Patrícia; et al. "Exploring the antioxidant, anti-inflammatory and antiallergic potential of Brazilian propolis in monocytes". Phytomedicine Plus 2 2 (2022): 100231. http://dx.doi.org/10.1016/j.phyplu.2022.100231. 10.1016/j.phyplu.2022.100231 Sofia mori. "ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system". Cellular and Molecular Life Sciences (2022): Open access • Accepted Almeida, Tânia; Moreira, Patrícia; Sousa, Fábio J.; Pereira, Cláudia; Silvestre, Armando J. D.; Vilela, Carla; Freire, Carmen S. R.. "Bioactive Bacterial Nanocellulose Membranes Enriched with Eucalyptus globulus Labill. Leaves Aqueous Extract for Anti-Aging Skin Care Applications". Materials 15 5 (2022): 1982. http://dx.doi.org/10.3390/ma15051982. Open access • Published • 10.3390/ma15051982 Patrícia Moreira; Fábio J. Sousa; Patrícia Matos; Brites, G; Maria José Gonçalves; Carlos Cavaleiro; Artur Figueirinha; et al. "Chemical Composition and Effect against Skin Alterations of Bioactive Extracts Obtained by the Hydrodistillation of Eucalyptus globulus Leaves". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/3/561. 10.3390/pharmaceutics14030561 Pereira, Ana Catarina; Madeira, Nuno; Morais, Sofia; Macedo, António; Cruz, Maria Teresa; Pereira, Cláudia M. F.. "Mitochondria Fusion upon SERCA Inhibition Prevents Activation of the NLRP3 Inflammasome in Human Monocytes". Cells 11 3 (2022): 433. http://dx.doi.org/10.3390/cells11030433. Open access • Accepted • 10.3390/cells11030433 Rocha, Maria Inês; Gonçalves, Maria José; Cavaleiro, Carlos; Cruz, Maria Teresa; Pereira, Cláudia; Moreira, Patrícia; Salgueiro, Lígia; Figueirinha, Artur. "Chemical characterization and bioactive potential of Artemisia campestris L. subsp. maritima (DC) Arcang. essential oil and hydrodistillation residual water". Journal of Ethnopharmacology 276 (2021): 114146. http://dx.doi.org/10.1016/j.jep.2021.114146. Open access • Published • 10.1016/j.jep.2021.114146 Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F.. "Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimers Disease". Biomedicines 9 8 (2021): 881. http://dx.doi.org/10.3390/biomedicines9080881. Open access • Published • 10.3390/biomedicines9080881 Fernandes, Tânia; Resende, Rosa; Domingues, Maria R.; Paula I. Moreira; Pereira, Cláudia Fragão. "Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model". European Journal of Clinical Investigation 51 S1 (2021): http://dx.doi.org/10.1111/eci.13567. Published Ana P. Marques; Rosa Resende; Diana F. Silva; Mariana Batista; Daniela Pereira; Brigite Wildenberg; Sofia Morais; et al. "Mitochondrial Alterations in Fibroblasts of Early Stage Bipolar Disorder Patients". Biomedicines (2021): https://www.mdpi.com/2227-9059/9/5/522. 10.3390/biomedicines9050522 Pereira, Cláudia. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy 8 (2021): 1-382. Published Pereira, Ana Catarina; Oliveira, Joana; Silva, Sónia; Madeira, Nuno; Pereira, Cláudia M.F.; Cruz, Maria T.. "Inflammation in Bipolar Disorder (BD): Identification of new therapeutic targets". Pharmacological Research 163 (2021): 105325. http://dx.doi.org/10.1016/j.phrs.2020.105325. Published • 10.1016/j.phrs.2020.105325 Domingues, Raquel; Pereira, Claúdia; Cruz, Maria Teresa; Silva, Ana. "Therapies for Alzheimer’s disease: a metabolic perspective". Molecular Genetics and Metabolism S1096-71 21 (2021): http://dx.doi.org/10.1016/j.ymgme.2021.01.011. Published • 10.1016/j.ymgme.2021.01.011 Silva, A.; Oliveira, A. S.; Vaz, C. V.; Correia, S.; Ferreira, R.; Breitenfeld, L.; Martinez-de-Oliveira, J.; et al. "Anti-inflammatory potential of Portuguese thermal waters". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-79394-9. Published • 10.1038/s41598-020-79394-9 Silva, Ana; Pereira, Marta; Carrascal, Mylène A.; Brites, Gonçalo; Neves, Bruno; Moreira, Patrícia; Resende, Rosa; et al. "Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models". International Journal of Molecular Sciences 21 20 (2020): 7791. http://dx.doi.org/10.3390/ijms21207791. 10.3390/ijms21207791 Oliveira, Ana Sofia; Vaz, Cátia Vicente; Silva, Ana; Correia, Sara; Ferreira, Raquel; Breitenfeld, Luiza; Martinez-de-Oliveira, José; et al. "In vitro evaluation of potential benefits of a silica-rich thermal water (Monfortinho Thermal Water) in hyperkeratotic skin conditions". International Journal of Biometeorology 64 11 (2020): 1957-1968. http://dx.doi.org/10.1007/s00484-020-01986-x. Published • 10.1007/s00484-020-01986-x Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patrícia; Coimbra, Judite R.M.; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge A.R.; et al. "New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimers Disease Models". Journal of Alzheimer's Disease 70 6 (2020): 1317-1337. http://dx.doi.org/10.3233/jad-200381. Published • 10.3233/jad-200381 R. Resende; T. Fernandes; A.C. Pereira; J. De Pascale; A.P. Marques; P. Oliveira; S. Morais; et al. "Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 6 (2020): 165752-165752. https://doi.org/10.1016/j.bbadis.2020.165752. Published • 10.1016/j.bbadis.2020.165752 Cátia S. D. Oliveira; Patrícia Moreira; Judite Resende; Maria T. Cruz; Cláudia M. F. Pereira; Artur M. S. Silva; Sónia A. O. Santos; Armando J. D. Silvestre. "Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts of Acacia dealbata". International Journal of Molecular Sciences 21 5 (2020): 1814-1830. https://doi.org/10.3390/ijms21051814. Open access • 10.3390/ijms21051814 Luísa Cortes; João Malva; Ana Cristina Rego; Cláudia F. Pereira. "Calcium Signaling in Aging and Neurodegenerative Diseases 2019". International Journal of Molecular Sciences 21 3 (2020): 1125-1125. https://doi.org/10.3390/ijms21031125. 10.3390/ijms21031125 Jan Parys; C Pereira; Carlos Villalobos. "The Eighth ECS Workshop on “Calcium Signaling in Aging and Neurodegenerative Diseases”". International Journal of Molecular Sciences (2019): https://www.mdpi.com/1422-0067/20/24/6263. 10.3390/ijms20246263 Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa. "Is Alzheimer’s disease an inflammasomopathy?". Ageing Research Reviews 56 (2019): 100966. http://dx.doi.org/10.1016/j.arr.2019.100966. 10.1016/j.arr.2019.100966 Oliveira, Ana Sofia; Vaz, Cátia Vicente; Silva, Ana; Ferreira, Sandra Saraiva; Correia, Sara; Ferreira, Raquel; Breitenfeld, Luiza; et al. "Chemical signature and antimicrobial activity of Central Portuguese Natural Mineral Waters against selected skin pathogens". Environmental Geochemistry and Health (2019): http://dx.doi.org/10.1007/s10653-019-00473-6. Published • 10.1007/s10653-019-00473-6 Coimbra, Judite R. M.; Marques, Daniela F. F.; Baptista, Salete J.; Pereira, Cláudia M. F.; Moreira, Paula I.; Dinis, Teresa C. P.; Santos, Armanda E.; Salvador, Jorge A. R.. "Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment". Frontiers in Chemistry 6 (2018): http://dx.doi.org/10.3389/fchem.2018.00178. Open access • Published • 10.3389/fchem.2018.00178 Placido, Ana I.; Pereira, Claudia M. F.; Correira, Sonia C.; Carvalho, Cristina; Oliveira, Catarina R.; Moreira, Paula I.. "Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells". Molecular Neurobiology 54 1 (2017): 154-168. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392133900014&KeyUID=WOS:000392133900014. 10.1007/s12035-015-9640-1 Oliveira, C. R.; Pereira, C.; Rego, A. C.; Moreira, P. I.; Cardoso, S.. "When, where and how: mitochondrial multifaceted dysfunction in Alzheimer's disease". European Journal of Clinical Investigation 47 (2017): 24-25. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000412099900035&KeyUID=WOS:000412099900035. Placido, Ana I.; Pereira, Claudia M. F.; Duarte, Ana I.; Candeias, Emanuel; Correia, Sonia C.; Carvalho, Cristina; Cardoso, Susana; Oliveira, Catarina R.; Moreira, Paula I.. "Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?". Cns & Neurological Disorders-Drug Targets 14 4 (2015): 518-533. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000354179100012&KeyUID=WOS:000354179100012. 10.2174/1871527314666150429112353 Mota, Sandra I.; Costa, Rui O.; Ferreira, Ildete L.; Santana, Isabel; Caldeira, Gladys L.; Padovano, Carmela; Fonseca, Ana C.; et al. "Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease". Biochimica Et Biophysica Acta-Molecular Basis of Disease 1852 7 (2015): 1428-1441. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000355715200021&KeyUID=WOS:000355715200021. 10.1016/j.bbadis.2015.03.015 Ferreira, Ildete Luisa; Ferreiro, Elisabete; Schmidt, Jeannette; Cardoso, Joao M.; Pereira, Claudia M. F.; Carvalho, Ana Luisa; Oliveira, Catarina R.; Cristina Rego, A.. "A beta and NMDAR activation cause mitochondrial dysfunction involving ER calcium release". Neurobiology of Aging 36 2 (2015): 680-692. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352454400014&KeyUID=WOS:000352454400014. 10.1016/j.neurobiolaging.2014.09.006 Correia, Sonia C.; Resende, Rosa; Moreira, Paula I.; Pereira, Claudia M.. "Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu". DNA and Cell Biology 34 4 (2015): 261-273. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352342300005&KeyUID=WOS:000352342300005. 10.1089/dna.2014.2757 Fonseca, Ana Catarina R. G.; Moreira, Paula I.; Oliveira, Catarina R.; Cardoso, Sandra M.; Pinton, Paolo; Pereira, Claudia F.. "Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells". Molecular Neurobiology 51 2 (2015): 610-622. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351311800015&KeyUID=WOS:000351311800015. 10.1007/s12035-014-8740-7 Valente, J.; Resende, R.; Zuzarte, M.; Goncalves, M. J.; Lopes, M. C.; Cavaleiro, C.; Pereira, C.; Salgueiro, L.; Cruz, M. T.. "Bioactivity and safety profile of Daucus carota subsp maximus essential oil". Industrial Crops and Products 77 (2015): 218-224. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000366065200028&KeyUID=WOS:000366065200028. 10.1016/j.indcrop.2015.08.037 Del Campo, M.; Oliveira, C. R.; Scheper, W.; Zwart, R.; Korth, C.; Mueller-Schiffmann, A.; Kostallas, G.; et al. "BRI2 ectodomain affects A beta(42) fibrillation and tau truncation in human neuroblastoma cells". Cellular and Molecular Life Sciences 72 8 (2015): 1599-1611. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351456000012&KeyUID=WOS:000351456000012. 10.1007/s00018-014-1769-y Valente, J.; Zuzarte, M.; Resende, R.; Goncalves, M. J.; Cavaleiro, C.; Pereira, C. F.; Cruz, M. T.; Salgueiro, L.. "Daucus carota subsp gummifer essential oil as a natural source of antifungal and anti-inflammatory drugs". Industrial Crops and Products 65 (2015): 361-366. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349430000046&KeyUID=WOS:000349430000046. 10.1016/j.indcrop.2014.11.014 Placido, Ana I.; Oliveira, Catarina R.; Moreira, Paula I.; Pereira, Claudia Maria F.. "Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells". Molecular Neurobiology 51 2 (2015): 571-590. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351311800012&KeyUID=WOS:000351311800012. 10.1007/s12035-014-8819-1 Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda E.; Ferreira-Marques, Marisa. "New promising peptides to inhibit BACE1: evaluation of compound efficiency in cellular and mouse models of Alzheimer’s disease". Sinapse (2015): http://www.geecd.org/images/GEECDFiles/29a_Reuniao_do_GEECD_ResumosSinapse.pdf. Published Campo Milan, Marta Del; Pereira, Cláudia; Scheper, W.; Zwart, R.; Hoozemans, Jeroen; Oliveira, Catarina; Teunissen, Charlotte. "MISFOLDED BRI2 ECTODOMAIN ACTIVATES CRITICAL PATHOLOGICAL PATHWAYS INVOLVED IN EARLY STAGES OF ALZHEIMER'S DISEASE". Alzheimer's & Dementia 10 4 (2014): P334. http://dx.doi.org/10.1016/j.jalz.2014.05.323. Published • 10.1016/j.jalz.2014.05.323 Valente, J.; Resende, R.; Zuzarte, M.; Goncalves, M. J.; Lopes, M. C.; Cavaleiro, C.; Pereira, C.; Salgueiro, L.; Cruz, M. T.. "Antifungal and anti-inflammatory claims for wild carrot essential oil". Planta Medica 80 16 (2014): 1454-1454. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345550400318&KeyUID=WOS:000345550400318. Fonseca, Ana Catarina; Oliveira, Catarina R.; Pereira, Claudia F.; Cardoso, Sandra M.. "Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells". Biochimica Et Biophysica Acta-Molecular Cell Research 1843 6 (2014): 1150-1161. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335627900010&KeyUID=WOS:000335627900010. 10.1016/j.bbamcr.2014.02.016 Gomes, S.; Martins, I.; Fonseca, A. C. R. G.; Oliveira, C. R.; Resende, R.; Pereira, C. M. F.. "Protective Effect of Leptin and Ghrelin against Toxicity Induced by Amyloid- beta Oligomers in a Hypothalamic cell Line". Journal of Neuroendocrinology 26 3 (2014): 176-185. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000333329700004&KeyUID=WOS:000333329700004. 10.1111/jne.12138 Placido, A. I.; Pereira, C. M. F.; Duarte, A. I.; Candeias, E.; Correia, S. C.; Santos, R. X.; Carvalho, C.; et al. "The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease". Biochimica Et Biophysica Acta-Molecular Basis of Disease 1842 9 (2014): 1444-1453. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340975400016&KeyUID=WOS:000340975400016. 10.1016/j.bbadis.2014.05.003 Fonseca, Ana Catarina R. G.; Ferreiro, Elisabete; Oliveira, Catarina R.; Cardoso, Sandra M.; Pereira, Claudia F.. "Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells". Biochimica Et Biophysica Acta-Molecular Basis of Disease 1832 12 (2013): 2191-2203. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000327567600030&KeyUID=WOS:000327567600030. 10.1016/j.bbadis.2013.08.007 Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F.. "Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons". Molecular and Cellular Neuroscience 52 (2013): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS. 10.1016/j.mcn.2012.09.005 Resende, R.; Marques, S.C.F.; Ferreiro, E.; Simões, I.; Oliveira, C.R.; Pereira, C.M.F.. "Effect of a-Synuclein on amyloid ß-Induced toxicity: Relevance to lewy body variant of alzheimer disease". Neurochemical Research 38 4 (2013): 797-806. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876164250&partnerID=MN8TOARS. 10.1007/s11064-013-0982-7 Martins, I.; Gomes, S.; Costa, R.O.; Otvos, L.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F.. "Leptin and ghrelin prevent hippocampal dysfunction induced by Aß oligomers". Neuroscience 241 (2013): 41-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876430099&partnerID=MN8TOARS. 10.1016/j.neuroscience.2013.02.062 Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions". Neurobiology of Aging 33 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS. 10.1016/j.neurobiolaging.2011.04.011 Ferreiro E; Baldeiras I; Ferreira IL; Costa RO; Rego AC; Pereira CF; Oliveira CR. "Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers.". (2012): http://europepmc.org/abstract/med/22701485. 10.1155/2012/735206 Mota, Sandra I.; Ferreira, Ildete L.; Pereira, Claudia; Oliveira, Catarina R.; Cristina Rego, A.. "Amyloid-Beta Peptide 1-42 Causes Microtubule Deregulation through N-methyl-D-aspartate Receptors in Mature Hippocampal Cultures". Current Alzheimer Research 9 7 (2012): 844-856. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000308863600009&KeyUID=WOS:000308863600009. Ferreiro, E.; Pereira, C.M.F.. "Endoplasmic reticulum stress: A new playER in tauopathies". Journal of Pathology 226 5 (2012): 687-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857998807&partnerID=MN8TOARS. 10.1002/path.3977 Marques, S.C.F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonça, A.; Santana, I.; Outeiro, T.F.; Pereira, C.M.F.. "Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice". Neuroscience 220 (2012): 256-266. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864770859&partnerID=MN8TOARS. 10.1016/j.neuroscience.2012.06.029 Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F.. "Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers". Aging Cell 11 5 (2012): 823-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS. 10.1111/j.1474-9726.2012.00848.x Mota, S.I.; Ferreira, I.L.; Pereira, C.; Oliveira, C.R.; Rego, A.C.. "Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures". Current Alzheimer Research 9 7 (2012): 844-856. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866468436&partnerID=MN8TOARS. 10.2174/156720512802455322 Marques, S.C.F.; Oliveira, C.R.; Pereira, C.M.F.; Outeiro, T.F.. "Epigenetics in neurodegeneration: A new layer of complexity". Progress in Neuro-Psychopharmacology and Biological Psychiatry 35 2 (2011): 348-355. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952900959&partnerID=MN8TOARS. 10.1016/j.pnpbp.2010.08.008 Ferreiro, Elisabete; Ferreira, Ildete Luisa; Cardoso, Joao M.; Pereira, Cláudia; Resende de Oliveira, Catarina; Rego, Ana Cristina Carvalho. "Mitochondria control NMDA receptor-dependent calcium rise evoked by amyloid-ß 1-42 oligomers in rat cortical neurons". Alzheimer's & Dementia: Journal of Alzheimer's Association 7 4 (2011): Published Ferreira, Ildete Luisa; Mota, Sandra Isabel; Costa, Rui Miguel Oliveira da; Padovano, C; Fonseca, Ana Catarina Ribeiro da Graça; Letra, Liliana; Resende de Oliveira, Catarina; et al. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Journal of Neurodegenerative Diseases 1 Supplement (2011): Published Mota, Sandra Isabel; Ferreira, Ildete Luisa; Resende de Oliveira, Catarina; Pereira, Cláudia; Rego, Ana Cristina Carvalho. "Amyloid-beta oligomers cause microtubule deregulation through NMDA receptors in mature hippocampal neurons". Journal of Neurodegenerative Disorders 1 Supplement (2011): Published Fonseca, A.C.R.G.; Resende, R.; Oliveira, C.R.; Pereira, C.M.F.. "Cholesterol and statins in Alzheimer's disease: Current controversies". Experimental Neurology 223 2 (2010): 282-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952583554&partnerID=MN8TOARS. 10.1016/j.expneurol.2009.09.013 Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria". Journal of Alzheimer's Disease 20 2 (2010): 625-636. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS. 10.3233/JAD-2010-091369 Marques, S.C.F.; Oliveira, C.R.; Outeiro, T.F.; Pereira, C.M.F.. "Alzheimer's disease: The quest to understand complexity". Journal of Alzheimer's Disease 21 2 (2010): 373-383. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957352488&partnerID=MN8TOARS. 10.3233/JAD-2010-100303 Marques, Sueli C. F.; Pereira, Claudia M. F.; Outeiro, Tiago F.. "Epigenetics and Neurodegeneration: A Connection Overlooked". Epigenetics: Mechanism, Functions and Human Effects (2010): 241-252. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278550400010&KeyUID=WOS:000278550400010. Ferreira, I. L.; Resende, R.; Ferreiro, E.; Rego, A. C.; Pereira, C. F.. "Multiple Defects in Energy Metabolism in Alzheimer's Disease". Current Drug Targets 11 10 (2010): 1193-1206. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000285183900002&KeyUID=WOS:000285183900002. Resende, Rosa; Oliveira, Catarina Resende; Pereira, Claudia M. F.. "ROLE OF GLYCOGEN SYNTHASE KINASE-3B ON TAU PHOSPHORYLATION IN ALZHEIMER'S DISEASE". Advances in Medicine and Biology, Vol 2 2 (2010): 197-210. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278696200007&KeyUID=WOS:000278696200007. Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R.. "Mitochondria as a therapeutic target in Alzheimer's disease and diabetes". CNS and Neurological Disorders - Drug Targets 8 6 (2009): 492-511. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS. 10.2174/187152709789824651 Ferreiro, E.; Costa, R.; Resende, R.; Marques, S.; Cardoso, S.; Oliveira, C. R.; Pereira, C.. "Communication between endoplamic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide". Journal of the Neurological Sciences 283 1-2 (2009): 280-281. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000268609400202&KeyUID=WOS:000268609400202. 10.1016/j.jns.2009.02.158 Fonseca, A.C.R.G.; Proena, T.; Resende, R.; Oliveira, C.R.; Pereira, C.M.F.. "Neuroprotective effects of statins in an in vitro model of alzheimer's disease". Journal of Alzheimer's Disease 17 3 (2009): 503-517. http://www.scopus.com/inward/record.url?eid=2-s2.0-67849099662&partnerID=MN8TOARS. 10.3233/JAD-2009-1067 Arduíno, D.M.; Raquel Esteves, A.; Filipa Domingues, A.; Pereira, C.M.F.; Cardoso, S.M.; Oliveira, C.R.. "ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells". BMB Reports 42 11 (2009): 719-724. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449102905&partnerID=MN8TOARS. Pereira, Cláudia; Fonseca, Ana Catarina Ribeiro da Graça; Resende, Rosa; Ferreiro, Elisabete; Resende de Oliveira, Catarina; Pereira, C. M. F.; Fonseca, A. C.; et al. "Statins prevent beta-amyloid-induced toxicity in cortical neurons". Journal of the Neurological Sciences 283 1 (2009): 281-281. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000268609400203&KeyUID=WOS:000268609400203. Published • 10.1016/j.jns.2009.02.159 Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126". Journal of Neurochemistry 104 3 (2008): 766-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS. 10.1111/j.1471-4159.2007.05048.x Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F.. "The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway". Neurobiology of Disease 30 3 (2008): 331-342. http://www.scopus.com/inward/record.url?eid=2-s2.0-43649083316&partnerID=MN8TOARS. 10.1016/j.nbd.2008.02.003 Resende, R.; Moreira, P.I.; Proença, T.; Deshpande, A.; Busciglio, J.; Pereira, C.; Oliveira, C.R.. "Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease". Free Radical Biology and Medicine 44 12 (2008): 2051-2057. http://www.scopus.com/inward/record.url?eid=2-s2.0-43849096294&partnerID=MN8TOARS. 10.1016/j.freeradbiomed.2008.03.012 Resende, R.; Ferreiro, E.; Pereira, C.; Oliveira, C.R.. "ER stress is involved in Aß-induced GSK-3ß activation and tau phosphorylation". Journal of Neuroscience Research 86 9 (2008): 2091-2099. http://www.scopus.com/inward/record.url?eid=2-s2.0-48249157930&partnerID=MN8TOARS. 10.1002/jnr.21648 Resende, R.; Ferreiro, E.; Pereira, C.; Resende de Oliveira, C.. "Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death". Neuroscience 155 3 (2008): 725-737. http://www.scopus.com/inward/record.url?eid=2-s2.0-49249118742&partnerID=MN8TOARS. 10.1016/j.neuroscience.2008.06.036 Pereira, Cláudia; Ferreiro, Elisabete; Costa, Rui Miguel Oliveira da; Resende, Rosa; Morais Cardoso, Sandra; Resende de Oliveira, Catarina. "Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer's disease–associated beta-amyloid peptide". Alzheimer’s and Dementia 4 4 (2008): T345-T345. Published Costa, R.; Ferreiro, E.; Oliveira, C. R.; Pereira, C.; Costa, Rui Miguel Oliveira da; Ferreiro, Elisabete; Resende de Oliveira, Catarina; Pereira, Cláudia. "Does mitochondria impairment affect endoplasmic reticulum function during amyloid-beta toxicity?". Journal of Neurochemistry 102 Supplement (2007): 68-69. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248991600162&KeyUID=WOS:000248991600162. Published Ferreiro, Elisabete; Eufrasio, Ana; Pereira, Claudia; Oliveira, Catarina R.; Rego, A. Cristina; Ferreiro, E.; Eufrásio, A.; et al. "Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells". Journal of Alzheimers Disease 12 3 (2007): 223-228. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252300000003&KeyUID=WOS:000252300000003. Resende, R.; Pereira, C.; Agostinho, P.; Vieira, A.P.; Malva, J.O.; Oliveira, C.R.. "Susceptibility of hippocampal neurons to Aß peptide toxicity is associated with perturbation of Ca2+ homeostasis". Brain Research 1143 1 (2007): 11-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947303240&partnerID=MN8TOARS. 10.1016/j.brainres.2007.01.071 Ferreiro, Elisabete; Resende, Rosa; Costa, Rui Miguel Oliveira da; Moreira, Paula Isabel; Morais Cardoso, Sandra; Pereira, Cláudia; Resende de Oliveira, Catarina; et al. "Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions". Free Radical Research 41 (2007): S11-S11. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300021&KeyUID=WOS:000252296300021. Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F.. "An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity". Neurobiology of Disease 23 3 (2006): 669-678. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS. 10.1016/j.nbd.2006.05.011 Resende, Rosa; Batista, M; Pereira, Cláudia; Resende de Oliveira, Catarina. "In vitro study of Amyloid-ß peptide toxicity. The role of physical state.". Proceedings of the 10th International Conference on Alzheimer’s Disease and Related Disorders (2006): 455-459. Published Ferreiro, EB; Oliveira, CR; Pereira, CM. "Endoplasmic reticulum dysfunction and oxidative stress induced by the prion peptide". Journal of Neurochemistry 94 (2005): 174-175. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000231673401076&KeyUID=WOS:000231673401076. Cardoso, SM; Ferreiro, E; Oliveira, CR; Pereira, C. "The crosstalk between the endoplasmic reticulum and mitochondria in Alzheimer's disease". Febs Journal 272 (2005): 55-55. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000234826100186&KeyUID=WOS:000234826100186. Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R.. "Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 405-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS. 10.2174/1568007054546072 Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R.. "Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 383-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS. 10.2174/1568007054546117 Cardoso, S.M.; Rego, A.C.; Pereira, C.; Oliveira, C.R.. "Protective effect of zinc on amyloid-ß 25-35 and 1-40 mediated toxicity". Neurotoxicity Research 7 4 (2005): 273-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744456147&partnerID=MN8TOARS. 10.1007/BF03033885 Ferreiro, Elisabete; Resende, Rosa; Resende de Oliveira, Catarina; Pereira, Cláudia. "Mechanism of amyloid-beta induced early synaptotoxicity.". Sinapse 5 1 (2005): 101-101. Published Loureiro, G; Rabaca, M A; Blanco, B; Andrade, S; Chieira, C; Pereira, C. "Aeroallergens sensitization in an allergic paediatric population of Cova da Beira, Portugal.". Allergologia et immunopathologia 33 4 (2005): 192-8. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:16045856&KeyUID=MEDLINE:16045856. 10.1157/13077742 Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F.. "Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-ß peptide". Journal of Neuroscience Research 76 6 (2004): 872-880. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642541799&partnerID=MN8TOARS. 10.1002/jnr.20135 Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R.; Pereira, C; Ferreiro, E; Cardoso, SM; de Oliveira, CR. "Cell degeneration induced by amyloid-ß peptides: Implications for Alzheimer's disease". Journal of Molecular Neuroscience 23 1-2 (2004): 97-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669435&partnerID=MN8TOARS. 10.1385/JMN:23:1-2:097 Pereira, Claudia; Agostinho, Paula; Moreira, Paula I; Duarte, Ana I; Santos, Maria S; Oliveira, Catarina R. "[Neuroprotection strategies: effect of vinpocetine in vitro oxidative stress models].". Acta medica portuguesa 16 6 (2003): 401-6. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:15631851&KeyUID=MEDLINE:15631851. Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R.. "Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models \| Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo". Acta Medica Portuguesa 16 6 (2003): 401-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS. Moreira, Paula; Pereira, Claudia; Santos, Maria S.; Oliveira, Catarina. "Effect of Zinc Ions on the Cytotoxicity Induced by the Amyloid beta-Peptide". Antioxidants & Redox Signaling 2 2 (2000): 317-325. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000207500700014&KeyUID=WOS:000207500700014. 10.1089/ars.2000.2.2-317 Pereira, CF; de Oliveira, CR. "Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis". Neuroscience Research 37 3 (2000): 227-236. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000088427400008&KeyUID=WOS:000088427400008. 10.1016/S0168-0102(00)00124-3 Pereira, C; Agostinho, P; Oliveira, CR; Pereira, C.; Agostinho, P.; Oliveira, C.R.. "Vinpocetine attenuates the metabolic dysfunction induced by amyloid beta-peptides in PC12 cells". Free Radical Research 33 5 (2000): 497-506. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000166441800006&KeyUID=WOS:000166441800006. 10.1080/10715760000301041 Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R.. "Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress". Experimental Neurology 161 1 (2000): 383-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS. 10.1006/exnr.1999.7270 Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C.. "Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide". Antioxidants and Redox Signaling 2 2 (2000): 317-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS. Cardoso, S.M.; Pereira, C.; Oliveira, C.R.. "Mitochondrial function is differentially affected upon oxidative stress". Free Radical Biology and Medicine 26 1-2 (1999): 3-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345222531&partnerID=MN8TOARS. 10.1016/S0891-5849(98)00205-6 Pereira, C.; Santos, M.S.; Oliveira, C.. "Involvement of oxidative stress on the impairment of energy metabolism induced by Aß peptides on PC12 cells: Protection by antioxidants". Neurobiology of Disease 6 3 (1999): 209-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033022771&partnerID=MN8TOARS. 10.1006/nbdi.1999.0241 Pereira, C; Santos, MS; Oliveira, C; Pereira, C.; Santos, M.S.; Oliveira, C.. "Metabolic inhibition increases glutamate susceptibility on a PC12 cell line". Journal of Neuroscience Research 51 3 (1998): 360-370. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000071805700009&KeyUID=WOS:000071805700009. 10.1002/(SICI)1097-4547(19980201)51:3<360::AID-JNR9>3.3.CO;2-7 Pereira, C; Santos, MS; Oliveira, C; Pereira, C.; Santos, M.S.; Oliveira, C.. "Mitochondrial function impairment induced by amyloid beta-peptide on PC12 cells". Neuroreport 9 8 (1998): 1749-1755. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000074198700015&KeyUID=WOS:000074198700015. 10.1097/00001756-199806010-00015 Cardoso, S.M.; Pereira, C.; Oliveira, C.R.. "The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes". Biochemical and Biophysical Research Communications 246 3 (1998): 703-710. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577242&partnerID=MN8TOARS. 10.1006/bbrc.1998.8563 Pereira, C.M.F.; Oliveira, C.R.. "Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress". Free Radical Biology and Medicine 23 4 (1997): 637-647. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030757990&partnerID=MN8TOARS. 10.1016/S0891-5849(97)00020-8 Pereira, C.; Ferreira, C.; Carvalho, C.; Oliveira, C.. "Contribution of plasma membrane and endoplasmic reticulum Ca2+-ATPases to the synaptosomal [Ca2+]i increase during oxidative stress". Brain Research 713 1-2 (1996): 269-277. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029928472&partnerID=MN8TOARS. 10.1016/0006-8993(95)01554-X Pereira, Cláudia; Resende de Oliveira, Catarina. "Effect of lipid peroxidation on [Ca2+]i of rat synaptosomes". Journal of Neurochemistry supplement (1993): S151D-S151D. Published
Journal issue	Pereira, Cláudia; Parys, Jan; Villalobos, Carlos. "Calcium Signaling in Aging and Neurodegenerative Diseases". International Journal of Molecular Sciences (2020): https://gbiomed.kuleuven.be/english/research/50000618/50753344. In press • Coeditor Pereira, Cláudia; Neves, Bruno Miguel; Krüger, Elka. "The Role of ER Stress and the UPR in Shaping Immunity". Frontiers in Immunology (2020): https://www.frontiersin.org/research-topics/9234/the-role-of-er-stress-and-the-upr-in-shaping-immunity#articles. Under revision • Coeditor
Newspaper article	Pereira, Cláudia Maria Pereira; Moreira, Paula I.; Cardoso, Sandra M.; Rego, Ana Cristina; Sousa, Fábio J.; Pereira, Ana Catarina. ""Exercício Saudável para Neurónios Saudáveis" - Chronicle for European Universities Games Coimbra 2018", Diário de Coimbra, 2018, Região das Beiras
Preprint	Jorge M. Alves-Silva; Patrícia Moreira; Carlos Cavaleiro; Cláudia Pereira; Maria Teresa Cruz; Lígia Salgueiro. "Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging". 2023. https://doi.org/10.20944/preprints202310.1432.v1. 10.20944/preprints202310.1432.v1
Thesis / Dissertation	Pereira, Cláudia Maria Fragão; Palmeira, Carlos. "Endoplasmic reticulum stress during amyloid ß peptide-induced cell death : role of mitochondria and glutamatergic N-methyl-D-aspartate receptors". PhD, 2011. http://hdl.handle.net/10316/18243. Pereira, Cláudia. "Mecanismos de degenerescência celular em dois modelos de stress oxidativo induzido por glutamato e pela proteína beta-amilóide. Implicações para a etiopatogenia da doença de Alzheimer". PhD, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2000. http://hdl.handle.net/10316/10178. Pereira, Cláudia. "Efeito da peroxidação lipídica na actividade respiratória mitocondrial e nos mecanismos de regulação do cálcio em sinaptossomas". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 1994. porbase.bnportugal.pt/ipac20/ipac.jsp?session=12508572JO65S.211562&profile=porbase&uri=link=3100018~!165619~!3100024~!3100022&aspect=basic_search&menu=search&ri=1&source=~!bnp&term=Pereira%2C+Cláudia+Maria+Fragão&index=AUTHOR.

Intellectual property

Patent

Armanda Emanuela Castro e Santos; Rosa Maria Branco de Matos Costa Resende; Cláudia Maria Fragão Pereira; Marisa Ferreira Marques; Teresa Pimenta Dinis Silva. 2021. "Peptide inhibitors of BACE1 for the treatment of neurological disorders".
Granted/Issued

Provisional application for patent

2022. "SMALL MOLECULES FOR USE IN PREVENTING AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES".
Disclosed
2021. "Integrated process for extracting bioactive compounds from eucalyptus biomass".
Disclosed
2021. "Essential oil or extract products with phenolic compounds obtained from the wastewater from the hydrodistillation of Eucalyptus globulus leaves, their uses, formulations, bacterial cellulose membranes and face masks that incorporate them".
Disclosed

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2021/03	Beneficial effects of compounds extracted from Eucalyptus globulus biomass on skin health	XXV TECNICELPA - International Forest, Pulp and Paper Conference, XI CIADICYP Tecnicelpa (webconference, Portugal)
2021/03	MITOCHONDRIAL (DYS)FUNCTION AND DYNAMICS IN FIBROBLASTS OF EARLY BIPOLAR DISORDER PATIENTS	20th WPA World Congress of Psychiatry World Psychiatry Association (virtual congress)
2021/02	EFFECT OF ENDOPLASMIC RETICULUM (ER) STRESS ON ER-MITOCHONDRIA CONTACTS IN THE INNATE IMMUNE SYSTEM	SPF Meeting 2021 Faculdade de Farmácia da Universidade de Lisboa (webconference, Portugal)
2020/09	Structural and functional alterations in endoplasmic reticulum-mitochondria contacts in Alzheimer's disease in vitro models	34 ª Reunião do GEECD Grupo de Estudos de Envelhecimento Cerebral e Demências (GEECD) (webconference, Portugal)
2020/02	Changes in the Protein Composition of Mitochondrial-Associated Membranes (MAMs) in Alzheimer’s disease	SPF Meeting 2020 Universidade de Coimbra Faculdade de Farmácia (Coimbra, Portugal)
2019/11/15	ER stress-induced sterile inflammation in Bipolar disorder (Award "Best Oral Communication")	1st Annual Meeting in Pharmaceutical Sciences Faculty of Pharmacy (Coimbra, Portugal)
2019/05	The cellular stress response in the innate immune system	53rd ESCI2019 Annual Meeting of the European Society for Clinical Investigation European Society for Clinical Investigation (Coimbra, Portugal)
2019/03/15	Impairment of the cellular stress response in neuropsychiatric disorders.	Seminar Institute of Biology and Molecular Genetics (IBGM) (Valladolid, Spain)
2019/03	Endoplasmic Reticulum Stress: new insights in metabolic disorders.	15th International Symposium of the Portuguese Society of Metabolic Disorders Portuguese Society of Metabolic Disorders (Coimbra, Portugal)
2017/09	Primary neuronal cultures as a cellular model to study ageing and age-related disorders	Course "Fundamentals of Animal Cell Culture" University of Aveiro, Portugal (Aveiro, Portugal)
2016/12	ER and mitochondria in Alzheimer’s disease: Best Friends Forever?	1st Meeting on Biomedical Research@UC University of Coimbra, Portugal (Coimbra, Portugal)
2015/11	Neurobiologia da doença Bipolar: rumo a novas estratégias terapêuticas e biomarcadores / Neurobiology of Bipolar disorder: towards novel therapeutic strategies and biomarkers	XI National Congress of Psychiatry Sociedade Portuguesa de Psiquiatria e Saúde Mental/Portuguese Society of Psychiatry and Mental Health (Vilamoura, Portugal)
2015/06/13	Memória e plasticidade neuronal / Memory and neuronal plasticity	X Jornadas de Audiologia Escola Superior de Tecnologias da Saúde de Coimbra (Coimbra, Portugal)
2014/03/29	Mecanismos moleculares subjacentes a` disfunção cerebrovascular na doença de Alzheimer / Molecular mechanisms underlying cerebrovascular dysfunction in Alzheimer's disease	2nd Annual Meeting Coimbra Health School Escola Superior de Tecnologias da Saúde de Coimbra (Coimbra, Portugal)
2014	Impairment of stress response during ageing	Coimbra & Newcastle Universities joint Summer school - Understanding the complexity of Ageing University of Coimbra, Portugal (Coimbra, Portugal)
2011/09	- Towards novel inhibitors of Alzheimer’s disease-associated beta-amyloid aggregation and toxicity: from statins as potential leads to the design of effective drugs	First III-UC Researcher Forum Interdisciplinary Research Institute (III), University of Coimbra (Coimbra, Portugal)
2011/09	Cross-talk between alpha-synuclein and beta-amyloid proteins in Alzheimer’s disease	First III-UC Researcher Forum Interdisciplinary Research Institute (III), University of Coimbra (Coimbra, Portugal)
2011/04/15	Mitochondrial dysfunction in Alzheimer’s disease: lessons from cellular models	Cooperativa de Ensino Superior e Politécnico Universitário (CESPU) (Gandra, Portugal)
2008/11	Disease-modification strategies for Alzheimer’s Disease	1st National Meeting of Therapeutic Chemistry University of Porto, Portugal (Porto, Portugal)
2008/05	Neurodegenerescência na doença de Alzheimer: lições obtidas com modelos celulares e animais Neurodegeneration in Alzheimer's disease: lessons from cellular and animal models	VI National Biochemistry Meeting Beira Interior University (Covilhã, Portugal)
2006/06/02	Fisiopatologia da doença de Alzheimer Physiopathology of Alzheimer's disease	Workshop on neurodegenerative diseases Moderna University (Lisbon, Portugal)
2006/02/10	Fisiopatologia da doença de Alzheimer e outras demências Physiopathology of Alzheimer's disease and other dementias	Theoretical-pratical course about dementia Hospitais da Universidade de Coimbra (Coimbra, Portugal)
2004/12	Neurodegeneration in Alzheimer’s disease induced by beta-amyloid peptides	XIV Congress of Biochemistry Portuguese Society for Biochemistry (SPB) (Vilamoura, Portugal)
2002/09	Cell degeneration induced by amyloid-beta peptides. Implications for Alzheimer’s disease	Novel Therapeutic Opportunities in Neurodegenerative Disease University of Aveiro, Portugal (Aveiro, Portugal)
1999/09	Oxidative stress hypothesis for the pathogenesis of Alzheimer’s disease	IV Congress of Free Radicals in Chemistry, Biology and Medicine (Troia, Portugal)
1998/11	ß-amyloid-associated oxidative stress and cytotoxicity: implications for Alzheimer’s disease	XI National Congress of Biochemistry Portuguese Society for Biochemistry (SPB) (Tomar, Portugal)
1997/12	ß-Amyloid toxicity in neurodegeneration	IV Meeting of the Portuguese Society for Neurosciences Portuguese Society for Neurosciences (SPN) (Coimbra, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2020/01 - Current	Circadian rhythm disruption in Bipolar disorder: from molecular mechanisms to novel therapeutic targets PhD fellowship from FCT: SFRH/BD/148653/2019 Supervisor	Doutoral Program in Health Sciences (Biomedical Sciences) (PhD) Universidade de Coimbra Faculdade de Medicina, Portugal
2020/01 - Current	Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism. PhD fellowship from FCT: SFRH/BD/148801/2019 Co-supervisor	Doutoral Program in Health Sciences (Biomedical Sciences) (PhD) Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - Current	Characterization of phytochemical components of Eucalyptus globulus leaves and their pharmacological potentials: a multi-functional insight DOUTORAMENTO EM EMPRESAS, # DBE UC-NAVIGATOR-06 Supervisor	Doctoral Program in Pharmaceutical Sciences (Pharmacology and Pharmacotherapy) (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 - 2021/02/22	Characterisation of glycoproteins involved in sea urchin adhesion Supervisor	Mestrado em Investigação Biomédica (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2021/01/29	The Impact of Protein Tyrosine Phosphatases on the activation of Intraepithelial Lymphocytes. Supervisor	Mestrado em Investigação Biomédica (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2020/12	Lipidomic alterations in the Mitochondria-Associated Membranes (MAMs) in Alzheimer's disease: analysis of biosynthetic enzymes in APPswe-overexpressing cells Co-supervisor	Corso di Laurea Magistrale in Biotecnologie genetiche e molecolari (Master) Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Italy
2017 - 2019/09	O papel do neuropeptídeo Y nas funções dos condrócitos articulares / The role of neuropeptide Y in articular chondrocyte functions Supervisor of Caren Jane Rodrigues	Mestrado em Investigação Biomédica /Master in Biomedical Research (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2019/09	Histological and morphological analysis of developing neuronal precursors derived from human iPS cells Supervisor of Daniela Catarina Gaspar Santos	Mestrado em Investigação Biomédica / Master in Biomedical Research (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2019/09	Alergénios cutâneos: Moléculas com uma aplicação terapêutica improvável para a doença de Alzheimer / Skin allergens: Molecules with an improbable therapeutic application for Alzheimer's disease Supervisor of Marta Sofia Rosendo Pereira	Mestrado em Investigação Biomédica / Master in Biomedical Research (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2019	Mitochondria-associated membranes: a platform for transferring endoplasmic reticulum stress signals to mitochondria in innate immune cells. does lithium promote an adaptive cellular response and survival? Supervisor	Master in Cellular and Molecular Biology (Neurobiology) (Master)
2016 - 2018	Deregulated inflammasome in Bipolar Disorder (BD): a matter of stress? Supervisor	Master in Cellular and Molecular Biology (Neurobiology) (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2018	Validation of a siRNA targeting PI3KCA gene towards colorectal cancer therapy Supervisor	Master in Biomedical Research (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2017	Role of miRNAs on cellular survival Supervisor	Master in Biomedical Research (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2017	Unravelling the circuits involved in ejaculation in mice (Mus musculus) Supervisor	Master in Biomedical Research (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2012 - 2016/02	Role of endoplasmic reticulum stress on Alzheimer's disease-associated neuronal and endothelial dysfunction Supervisor	Doutoramento em Ciências da Saúde (Ramo Ciências Biomédicas) (PhD) Universidade de Coimbra Faculdade de Medicina, Portugal
2014 - 2016	Modulation of mitochondrial dynamics by the Influenza A virus Supervisor	Master in Biomedical Research (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - 2016	Endothelial cell response to deregulated proteostasis: analysis of ghrelin's protective action Supervisor	Master in Cellular and Molecular Biology (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - 2015	Role of reactive oxygen species in inflammasome activation in microglia under stress conditions Supervisor	Master in Medicine (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - 2015	Endocytic trafficking mechanisms in Alzheimer’s disease: role of the actin regulators Bin1 and CD2AP Supervisor	Master in Biomedical Research (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - 2014	Loss of proteostasis in brain endotelial cells in an in vitro model of Alzheimer’s disease Supervisor	PhD program in Biochemistry (Cellular and Molecular Biology) (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2013	NMDA receptors-associated events and oxidative stress in models of Alzheimer’s disease Co-supervisor	PhD program in Biology (Cellular Biology) (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2012	Chromatin remodeling in Alzheimer’s disease pathogenesis Supervisor	PhD program in Biology (Cellular Biology) (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2007 - 2011	Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors Supervisor	PhD program Biology (Cellular Biology) (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2010	Neuroprotection by leptin and ghrelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer's disease Supervisor	Master in Biochemistry (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2010	Role of endothelial cells on survival of mature neurons. Implications for the etiopathogenesis of Alzheimer’s disease Supervisor	Master in Cellular and Molecular Biology (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2010	Toxicity of amyloid-beta peptide in hypothalamic cells and protection by leptin and ghrelin. Implications for the etiopathogenesis of Alzheimer's disease Supervisor	Master in Biochemistry (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2010	From cerebrovascular alterations to therapeutical options in Alzheimer's disease Supervisor	Master in Medicine (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2005 - 2009	Neuroprotective effects of statins in an in vitro model of Alzheimer’s disease Supervisor	Master in Biology (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2008	Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides. Implications for the etiopathogenesis of Alzheimer’s and Prion’s diseases Supervisor	PhD program in Biology (Cellular BiologyY (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2008	Neurotoxicity induced by amyloid-beta peptide. The role of different assembies Co-supervisor	PhD programa in Health Sciences (Biomedical Sciences) (PhD)

Event organisation

	Event name Type of event (Role)	Institution / Organization
2011 - Current	Science Communication “Ocupação Científica nas Férias de Verão” intership for secundary school students during summer holidays (1-2 weeks) “Ups and downs of Bipolar disorder”, September 2019 “Are our cells stressed?”, September 2018 “When Science gets water...”- stying the therapeutical propoerties of thermal mineral waters at center region of Portugal, July 2017 “Why does our memory fails when we age?” July 2011 (2011) Other (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 - 2019	8th edition of the European Calcium Society (ECS) workshop, “Calcium Signaling in Aging and Neurodegenerative Disorders 2019”, University of Coimbra, Portugal (2019/09/18 - 2019/09/20) Workshop (President of the Organising Committee)	Universidade de Coimbra, Portugal
2019 - 2019	"Neuroinflammation in Alzheimer’s disease", seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 11 April 2019 Speaker: Michael Heneka, German Center for Neurodegenerative Disorder (DZNE), Bonn, Germany; Department of Neurodegeneration Diseases and Geriatric Psychiatry, University Hospital of Bonn, Bona, Germany (2019/04/11 - 2019/11/11) Seminar (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2018	1st Meeting on Vesicular Biology (MVB) (http://cost-proteostasis.eu) (2018/02/16 - 2018/02/17) Meeting (Member of the Scientific Committee)	Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2018	"Imaging of neuroinflammation and oxidative stress in psychotic disorder" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 21 December 2018 Speaker: Tiago Reis Marques, Mandsley Hospital; Institute of Psychiatry, King's College; Imperial College, London, United Kingdom (UK) (2018/12/21 - 2018/12/21) Seminar (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2018	"ER-mitochondria cross-talk in neurodegeneration: focus on Familial Alzheimer's disease" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 27 April 2018. Speaker: Paola Pizzo, Department of Biomedical Sciences, University of Padova, Padova, Italy (2018/04/27 - 2018/04/27) Seminar (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2018	"Tau therapeutics in brain pathology: Exploring the link between depression and Alzheimer’s disease" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 23 February 2018. Speaker: Ioannis Sotiropoulos, Life and Health Sciences Research Institute (ICVS), Medical School, University of Minho, Portugal (2018/02/23 - 2018/02/23) Seminar (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2015	"Endoplasmic reticulum stress in the Drosophila eye" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 08 May 2015. Speaker: Pedro Domingos, Laboratory Cell Signalling in Drosophila, ITQB, Oeiras, Portugal (2015/05/08 - 2015/05/08) Seminar (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2013	XIII Reunião da Sociedade Portuguesa de Neurociências / XIII Meeting of the Portuguese Society for Neuroscience (2013/05/30 - 2013/06/01) Meeting (Member of the Organising Committee)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - 2010	2nd National Meeting on Medical Chemistry (2010/11/28 - 2010/11/30) Meeting (Member of the Scientific Committee)	Universidade de Coimbra, Portugal
2004 - 2009	Science Communication "Brain Awareness Week", "Ciencia Viva nas Ferias de Verão", "Science Week", Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal (laboratorial and other activities for students and general audiences) (2004 - 2009) Other (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008 - 2008	"Why Alzheimer is a disease of memory: the attack on synapses by Abeta oligomers" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 16 June 2008. Speaker: William L. Klein, Cognitive Neurology and Alzheimer's Disease Center, Nanoscale Science and Engineering Center, Northwestern University, Evanston, IL, USA (2008/06/16 - 2008/06/16) Seminar (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - 2005	"Synucleins in Parkinson's disease: novel insights" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 24 June 2005. Speaker: Cristine Alves da Costa, Institut de Pharmacologie Moléculaire et Cellulaire, IPMC, CNRS, UMR, Valbonne, France. (2005/06/24 - 2005/06/24) Seminar (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004 - 2004	"Molecular mechanisms of neuronal degeneration in Down’s syndrome and Alzheimer’s disease" seminar, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 26 November 2004. Speaker: Jorge Busciglio, University of California, Irvine, USA. (2004/11/26 - 2004/11/26) Seminar (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2017/11/10 - Current	Módulo de formação TIPs “II.III.I – Ensino em Grandes Grupos (Aulas Teóricas)”, Gabinete de Educação Médica, Faculdade de Medicina, Universidade de Coimbra, Portugal, 10 de novembro 2017. Course TIPs “II.III.I – teaching for large groups (theoretical classes)”, Medical Education Office, Faculty of Medicine, University of Coimbra, Portugal Workshop	Módulo de formação TIPs “II.III.I – Ensino em Grandes Grupos (Aulas Teóricas)” Universidade de Coimbra, Portugal
2004 - Current	Science Communication Science dissemination activities (laboratorial and other activities for students and general audiences) at the Center region of Portugal Other	Brain Awareness Week", "Ciencia Viva at Summer Holidays", "Science and Technology Week", "European Night of Researchers", Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1992 - Current	Poster communication Co-author of more than 100 poster presentations in national and international scientific meetings Congress	na Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1992 - Current	Oral communications Co-author of more than 50 oral presentations in national and international scientific meetings Congress	na Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/09/01 - 2008/09/12	Curso “ciência dos animais de laboratório” / training in "Science of laboratory animals" Curso acreditado pela FELASA (nº 020/08) seguindo as recomendações deste organismo para a formação e treino de pessoas para manipulação de animais de laboratório na categoria C (80 horas). Atribuição pela Direcção Geral de Veterinária de acreditação como Investigadora-Coordenadora Other	Curso “Ciência de Animais de Laboratório” Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/12/13 - 2007/12/14	Curso “The Teaching Improvement Project”, Departamento de Educação Médica, Faculdade de Medicina, Universidade de Coimbra, Portugal Course “The Teaching Improvement Project”, Medical Education Department, Faculty of Medicine, University of Coimbra, Portugal Workshop	The Teaching Improvement Project Universidade de Coimbra, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2020/12/15	Role of damaged lysosomes on endothelial cells during heart failure with preserved ejection fraction development President of the jury	Carlos Daniel Ferreira Rafael Pita (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2020/03/10	Dysfunctional dendritic and axonal activity in Alzheimer's disease - identifying possible therapeutic targets (Thesis) Main arguer	Alexandra Lopes Ramos Rodrigues (Other) Universidade de Coimbra Faculdade de Medicina, Portugal
2020/01/09	The role of ageing in polyglutamine-induced neurodegeneration. A Study in Machado -joseph disease models (Thesis) Arguer	Dina Maria da Silva Rodrigues Pereira (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019/11	On the persistence of therapy: the potential of miRNA modulation in Alzheimer's disease Thesis Member	Ana Teresa de Barros Viegas (PhD) Universidade de Coimbra Faculdade de Medicina, Portugal
2019/10/17	Role of amyloid-beta peptide on calcium and mitochondrial dyshomeostasis in hippocampal neurons: role of histone deacetylases (Thesis) Main arguer	Daniela Marinho Lopes (Master) Universidade do Porto Faculdade de Medicina, Portugal
2019/09	The changing brain in Alzheimer's disease: is the retina a mirror of disease onset and progression? (Thesis) Main arguer	Samuel Filipe Duarte Chiquita (PhD) Universidade do Porto, Portugal
2018/10	Chemo-enzymatic synthesis of new flavonoid derivatives with anti-inflammatory activity (Thesis) Main arguer	Joana Filipa Catarino Alves (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/10	Effect of essential oils and their major compounds on endothelial dysfunction associated with pulmonary arterial hypertension (Thesis) Main arguer	Julia Pereira Barbeitos (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/09	Pesquisa de biomarcadores nas doenças de Alzheimer e Parkinson: uma abordagem proteómica às PBMCs President of the jury	Rafael Ribeiro Santos Silva (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/09	Deregulated inflammasome in Bipolar Disorder (BD): a matter of stress? Supervisor	Ana Catarina Pereira (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/09	Validation of a siRNA targeting PI3KCA gene towards colorectal cancer therapy Supervisor	Rute Alexandra Henriques Tavares (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/07	Cellular and Molecular Biology (Thesis) Main arguer	Cristiano Filipe Brás de Sousa (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/07	Neurosciences (Thesis) Main arguer	Leonor Pedro Oliveira Ribeiro Rodrigues (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2018/06	Cardiovascular Sciences President of the jury	Alexandre Manuel Monteiro Gonçalves (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09	Cellular and Molecular Biology President of the jury	Ricardo Alexandre Fróis Martins (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09	Strategies to reverse cellular senescence and enhance progerin clearance in Hutchinson-Gilford Progeria Syndrome President of the jury	Ana Sofia Marques Leal (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09	The interaction of Giardia lamblia with macrophage cells: the action of parasite proteases on iNOS, COX-2 and p65RelA inflammatory proteins President of the jury	Ágata Filipa Bandeira Lourenço (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09	Cellular and Molecular Biology President of the jury	Ana Rita Abrantes Dias (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09	Glucocorticoid effects in the developing brain : a road to neuropsychiatric disorders President of the jury	Helena Alexandra Ribeiro de Carvalho Pinheiro (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09	Repeated systemic transplantation of mesenchymal stromal cells : a therapeutic strategy for Machado-Joseph Disease? President of the jury	Adriana Isabel do Vale Marcelo (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09	Circuitos envolvidos no desencadeamento da ejaculação em ratinhos (Mus musculus) Supervisor	Ana Rita Pimentel (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09	Cellular and Molecular Biology President of the jury	Joana Filipa Almeida Perdigão (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09	Cellular and Molecular Biology President of the jury	João Afonso Azevedo Pereira da Silva (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/07	O papel dos miRNAs na sobrevivência celular Supervisor	Catia Alexandra Seabra Vieira (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/07	Cellular and Molecular Biology President of the jury	Sara Filipa Pereira Cruz (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/07	Neurosciences/neurodegenerative diseases (Thesis) Main arguer	Diogo Miguel Matos Vila Verde (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/02	Cellular and Molecular Biology President of the jury	Mónicas Francisco Silva (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09	Resposta de célula endotelial à desregulação proteostática: avaliação da ação protetora da grelina Supervisor	Daniela Alexandra Dinis Costa (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09	Modulação da dinâmica mitocondrial pelo vírus Influenza A Supervisor	Inês Veríssimo (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09	Cellular and Molecular Biology President of the jury	Joana Filipa Pereira Ferreira (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09	Cellular and Molecular Biology President of the jury	André Emanuel Serra Lopes (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/06	Cellular and Molecular Biology President of the jury	Yolanda Sofia Pires Afonso (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/06	Cellular and Molecular Biology President of the jury	Ágata Filipa Bandeira Lourenço (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/03	Neurosciences (Thesis) Arguer	Mariana Botelho da Rocha (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/02	Role of endoplasmic reticulum stress on Alzheimer's disease-associated neuronal and endothelial dysfunction Supervisor	Ana Isabel Plácido (PhD) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/12	Biotechnology (Thesis) Main arguer	Marta Isabel Heitor Cerejo (PhD) Universidade Nova de Lisboa, Portugal
2015/10	Endocytic trafficking mechanisms in Alzheimer’s disease: role of the actin regulators Bin1 and CD2AP Supervisor	Laura Nunes Soares Sequeira Salavessa (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/10	Role of reactive oxygen species in inflammasome activation in microglia under stress conditions Supervisor	Rafael Dias Azevedo (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09	Post-translational modifications of tau protein: implications for Alzheimer's disease (Thesis) Main arguer	Rui Miguel Ferreira Gomes (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/09	Cellular and Molecular Biology President of the jury	Emanuel Lima (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09	Cellular and Molecular Biology President of the jury	Rita Alexandra Pereira de Carvalho (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09	Cellular and Molecular Biology President of the jury	Daniela Costa Batista de Almeida (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/07	Cellular and Molecular Biology (Thesis) Main arguer	Rui Mendes (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/12	Neurosciences/Neurodegenerative diseases (Thesis) Main arguer	Dina Maria da Silva Rodrigues Pereira (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/10	Biotechnology (Thesis) Main arguer	Carla Tavares (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/10	Technology (Thesis) Main arguer	Carla Anita Gomes Tavares (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/09	Cellular and Molecular Biology (Thesis) Main arguer	Marcos Schaan Profes (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/03	Loss of proteostasis in brain endotelial cells in an in vitro model of Alzheimer’s disease Supervisor	Ana Catarina Fonseca (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/12	Cellular and Molecular Biology (Thesis) Main arguer	Patrícia Irene da Silva Inácio (PhD) Instituto Gulbenkian de Ciência, Portugal
2013/10	Technology (Thesis) Main arguer	Rita Videira (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2013/09	Cellular and Molecular Biology (Thesis) Main arguer	Valeria de Rosa (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/09	Biochemistry (Thesis) Main arguer	Catarina Marques (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/09	Biochemistry (Thesis) Main arguer	Catarina Marques (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/07	Cellular and Molecular Biology (Thesis) Main arguer	Rita Marisa Gomes Malheiros (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/07	Biochemistry (Thesis) Main arguer	Andreia Veríssimo Luís (Master) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2013/07	Biochemistry (Thesis) Main arguer	Anna Pliássova (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/05	NMDA receptors-associated events and oxidative stress in models of Alzheimer’s disease Supervisor	Sandra Isabel Mota (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/12	Neurosciences/neurodegenerative disorders Thesis Member	Daniela Arduíno (PhD) Universidade de Coimbra Faculdade de Medicina, Portugal
2012/12	Cellular and Molecular Biology (Thesis) Main arguer	Paula isabel Meira Gonçalves (Master) Universidade do Porto Faculdade de Medicina, Portugal
2012/11	Neurosciences/neurodegenerative diseases Thesis Member	Sónia Catarina de Sousa Correia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/07	Biochemistry (Thesis) Main arguer	Milene Gonçalves (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/06	Chromatin remodeling in Alzheimer’s disease pathogenesis Supervisor	Sueli Cristina Marques (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/11	Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors Supervisor	Rui Miguel Oliveira Costa (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/07	Cellular and Molecular Biology (Thesis) Main arguer	Bruno Vasconcelos (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2011/07	Biomedical Engineering (Thesis) Main arguer	Margarida Guerra (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/05	Neurosciences/Regenerative medicine (Thesis) Main arguer	Alexandra Rosa (PhD) Universidade de Coimbra Faculdade de Medicina, Portugal
2010/11	Neurosciences (Thesis) Main arguer	Miguel Bajouco (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2010/07	Toxicity of amyloid-beta peptide in hypothalamic cells and protection by leptin and ghrelin. Implications for the etiopathogenesis of Alzheimer's disease Supervisor	Sílvia Gomes (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/07	Role of endothelial cells on survival of mature neurons. Implications for the etiopathogenesis of Alzheimer’s disease Supervisor	Ana Isabel Plácido (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/07	Neuroprotection by leptin and ghrelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer's disease Supervisor	Isaura Vanessa Martins (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/07	Neurosciences/neurodegenerative disorder (Thesis) Main arguer	Diana Silva (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/07	Cellular and Molecular Biology (Thesis) Main arguer	Ana Soraia Barão (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/07	Cellular and Molecular Biology (Thesis) Main arguer	Master in Cellular and Molecular Biology (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2010/03	From cerebrovascular alterations to therapeutical options in Alzheimer's disease (Thesis) Main arguer	Daniel Ramos Andrade (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2009/11	Neurosciences/Neurodegenerative disorders (Thesis) Main arguer	João Pedro Lopes (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/09	Validating microtubules as a potential neuroprotective target – effect of microtubule-interacting agents in a NGF deprivation model (Thesis) Main arguer	António José Folgado Laranjeira (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/06	Neuroprotective effects of statins in an in vitro model of Alzheimer’s disease Supervisor	Ana Catarina Fonseca (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/12	Neurotoxicity induced by amyloid-beta peptide. The role of different assembies Supervisor	Rosa Maria Matos Branco Resende (PhD) Universidade de Coimbra Faculdade de Medicina, Portugal
2008/07	Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides. Implications for the etiopathogenesis of Alzheimer’s and Prion’s diseases Supervisor	Elisabete Batista Ferreiro (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Association member

	Society Organization name	Role
2000 - Current	Sociedade Portuguesa de Neurociências (SPN) (http://www.spn.org.pt/)	Member
2017 - 2019	Associação de Pais e Encarregados de Educação, Escola Secundária José Falcão, Coimbra, Portugal	Membro da Direção
2015 - 2017	Associação de Pais e Encarregados de Educação, Escola Secundária Infanta D. Maria, Coimbra, Portugal	Presidente

Committee member

	Activity description Role	Institution / Organization
2019/11 - Current	Assessora do Vice-Diretor para a Investigação, Faculdade de Medicina, Universidade de Coimbra, Portugal Advisor / Consultant	Universidade de Coimbra Faculdade de Medicina, Portugal
2007 - Current	Principal Investigator - sub-group "Endoplasmic reticulum (ER) stress response and ER-mitochondria axis", CNC, University of Coimbra, Portugal Coordinator	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020 - 2026	UC-coordinated EU-funded MIA-Portugal project aimed to create the Multidisciplinary Institute of Ageing (MIA) that will be integrated into the Ageing@Coimbra Vitality Campus, a European Innovation Partnership on Active and Healthy Aging reference site Member	Universidade de Coimbra, Portugal
2019 - 2021	Membro da Assembleia da Faculdade de Medicina, Universidade de Coimbra, Portugal Member	Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2020	Group leader "Cell signaling and metabolism in disease" (turnover every 2 years between PIs), Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal Coordinator	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2019	“ERA@UC – Enhancing Research in Ageing at the University of Coimbra” - selection of ERA Chair holder Member	Universidade de Coimbra Faculdade de Medicina, Portugal
2012 - 2015	Membro da Direção do Gabinete de Apoio à Investigação (GAI), Faculdade de Medicina, Universidade de Coimbra, Portugal Board member "Research Support Office", Faculty of Medicine, University of Coimbra, Portugal Member	Universidade de Coimbra Faculdade de Medicina, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2020/09 - Current	"Doenças do neurodesenvolvimento, psiquiatria e saúde mental/Neurodeveleopment, psychiatry and mental health diseases"	Master in Molecular and Translational Neurosciences (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2020/09 - Current	"Mecanismos de disfunção neuronal e neurodegenerescência"Mechanisms of neuronal dysfunction and neurodegeneration"	Master in Molecular and Translational Neurosciences (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - Current	Bioquímica I / Biochemistry I (collaborator pratical classes)	Integrated Master in Medicine (Mestrado integrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2016 - Current	Investigação Aplicada I / Applied Research I (Regent)	Integrated Master in Medicine (Mestrado integrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - Current	"Fundamentos de Neurociências/Principals of Neurosciences"	Integrated Master in Medicine (Mestrado integrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - Current	"Métodos e Técnicas de Investigação/Research Methods and Techniques”	Master in Biomedical Research (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - Current	“Projeto Integrado Multidisciplinar (PIM)/Multidisciplinar Integrated Project”).	Master in Biomedical Research (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - Current	"Métodos e Técnicas de Investigação/Research Methods and Techniques"	Doctoral Program in Health Sciences (Doutoramento)	Universidade de Coimbra Faculdade de Medicina, Portugal
2012 - Current	Biologia do Envelhecimento / Biology of Aging (collaborator)	Ciências de Engenharia Biomédica (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - Current	Neurobiologia II / Neurobiology II (collaborator)	Ciências de Engenharia Biomédica (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - Current	Neurobiologia I / Neurobiology I (collaborator or regent every 2 years)	Engenharia Biomédica (Mestrado)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - Current	"Neurociência/Neuroscience" (Professor Titular/Regent)	Physiotherapy (Ensino básico 1º ciclo)	Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2009 - 2015	Neurobiologia / Neurobiology (Professor titular/regent)	Análises Clínicas e de Saúde Pública (Bacharelato)	Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2005 - Current	"L'Oréal for Women in Science" Prize (L'Oréal/UNESCO/FCT) Evaluator	Fundação para a Ciência e a Tecnologia, Portugal	L'Oréal SA
2000 - Current	Invited reviewer of international journals (e.g. Biochimica Biophysica Acta (BBA); British Journal of Pharmacology; Cell Death and Differentiation; Current Alzheimer’s Research; European Journal of Neuroscience; Experimental Neurology; Free Radical Biology & Medicine; International Journal of Alzheimer’s Disease; Journal of Aging Research; Journal of Alzheimer’s Disease; JNeurobiology of Aging; Neurobiology of Disease; The Journal of Neuroscience; The Journal of Pathology; Therapeutical Journal of Experimental Medicine) Evaluator
2022/02/01 - 2022/02/28	Expert Evaluator, CIVIS3i H2020-MSCA-COFUND Postdoctoral Fellowships Programme, Civis European University, CIVIS3i Alliance Programme for International, Interdisciplinary, Intersectoral Research and Training for Experienced Researchers Evaluator	European Union, Belgium	European Union
2021/05/01 - 2021/05/31	Competition for the recruitment of a PhD scholarship in Companies (BDE UC-navigator-06), a collaboration project with the company Navigator Paper Figueira, S.A., RAIZ - Forest and Paper Research Institute and the Inpactus project Evaluator	Universidade de Coimbra, Portugal
2014 - 2016	Evaluation panels PhD and post-doc grants "Experimental Biology and Biochemistry" (2014 and 2015); final reports Neurosciences, Aging and Degenerative Disorders" (2014-2016) Evaluator	Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia
2003 - 2015	Evaluation board of international research agencies Agence Nationale de la Reserche (ANR), França (2015) Deutsche Forschungsgemeinschaft (DFG), Alemanha (2015) Alzheimer’s Association, USA (2003, 2010, 2011, 2012, 2013) Szech Science Foundation, República Checa (2008, 2013) Research into Ageing, UK (2008) Ministry of Science and Technological Development of the Republic of Serbia, Sérvia (2010) FONDAZIONE TELETHON, Itália (2013) Medical Research Council, UK (2014) Evaluator

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2018	A prevalência e incidência das doenças neurodegenerativas. Pereira C., Pereira A.C., Sousa F., Moreira P.I., Cardoso S.M., Rego A.C. Crónica Diário de Coimbra “Exercício saudável para neurónios saudáveis”, Ciência do CNC nos Jogos Europeus Universitários 2018.	Diário de Coimbra
2012/10	Cérebro e memória- comentário por convite	Porque é difícil escolher?

Interview (tv / radio show)

	Program	Topic
2006/09 - 2006/09	Sociedade Civil	Alzheimer
2005/05 - 2005/05	Entre Nós	Alzheimer
2005/04 - 2005/04	Portugueses Excelentíssimos	Alzheimer

Journal scientific committee

	Journal title (ISSN)	Publisher
2019 - Current	International Journal of Molecular Sciences (1422-0067)	MDPI AG
2014 - Current	Frontiers in Cellular Neuroscience (1662-5102)	Frontiers Media SA

Other jury / evaluation

	Activity description	Institution / Organization
2013 - Current	Evaluation board to select project fellows: - “InPaCTus” Innovative products and Technologies. COMPETE2020 nº 21874, collaboration with Navigator Paper Figueira, S.A. and RAIZ - “HealthyAging2020” project, ref. CENTRO-01-0145-FEDER-000012 (FEDER- CENTRO2020) - “Study of tTherapeutic Properties of Spring Thermal Waters- Dermocosmetics” project, Âncora Inovação do Programa PROVERE de Valorização das Estâncias Termais da Região Centro (FEDER- CENTRO2020) - "Neurosciences Matero Belard 2013" award	Universidade de Coimbra, Portugal

Distinctions

Award

2017	Edgar Cruz e Silva Award (PI: Armanda Santos) Fundação Edgar Cruz e Silva, Portugal
2012	Edgar Cruz e Silva Award (PI: Dora Brites) Fundação Edgar Cruz e Silva, Portugal
2011	Best Poster Award at the First PF2MUC Symposium, Coimbra, Portugal. Universidade de Coimbra Faculdade de Medicina, Portugal
2010	Aging and Cerebral Dementia, Alzheimer's disease Award (PI: E Ferreiro, post-doc) Sociedade Portuguesa de Neurociências, Portugal
2007	Third Prize of Best Poster Award "5th International Congress on Vascular Dementia", Budapest, Hungary
2004	L´Oréal Award "For Women in Science" (L´Oréal/UNESCO/FCT) Fundação para a Ciência e a Tecnologia, Portugal

Other distinction

2021	Livro "Mulheres na Ciência" (3ª edição) Ciência Viva, Portugal