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Sofia Azeredo Gaspar Pereira (SAP) completed her PhD in Pharmacology (2010) and is Assistant Professor with aggregation at NOVA Medical School, NMS Universidade Nova de Lisboa. She is/has been Vice-director of the PhD Program in Biomedicine, Coordinator of the Therapeutic Drug Monitoring and Responsible for the Analytical Facility. She is a researcher at iNOVA4Health FCT Research Unit. SAP is a pharmacologist and the head of the Renal, Cardiovascular and Metabolic Pharmacology lab at NOVA Medical School. SAP leads a research line with collaboration to Peritoneal Dialysis Unit of CHLO, dedicated to biomarkers and clinical pharmacology studies for better outcomes in this renal replacement therapy, and led pioneer work that links galectin-3 to membrane failure. SAP research foous AhR as a druggable target in cardiovascular-renal disease spectrum. She investigates AhR involvement in fibrosis and metabolic adaptations to microenvironmental conditions. SAP is/has been a member of two European networks on hypertension and Kidney disease; she integrates the network Pharmacological regulation of NRF2 in non communicable diseases; She is a member of the working group translational nephrology at the Portuguese Society of Nephrology; She is/has been PI of a patent of a compound to treat diseases associated with HDL-dysfunction; member of the team of 2 clinical trials Her team has identified mechanisms of toxicity for 5 drugs and a biomarker of kidney disease progression conducting research in experimental models ( rodents, zebra fish, 3D cell culture) and clinical studies. She has been collaborating (since 2001) with Clinical Teams from Hospitals in Lisbon Area, with several common publications. Applying a mechanistically-oriented approach, Sofia´s team has identified populations of patients that are at higher risk for adverse drug reactions towards precision therapy (eg. gender differences, menopause). Currently, and supported by her background in drug toxicity, she is investigating how drug metabolic pathways impact non-communicable diseases Arterial Hypertension, Kidney Disease) towards patients deeply phenotyping and stratification and looking for a new generation of drugs targeting the interaction ENVIRONMENT-DISEASE.
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Identification

Personal identification

Full name
Sofia Azeredo Gaspar Pereira

Citation names

  • Pereira, Sofia A.

Author identifiers

Ciência ID
6B13-7601-73A2
ORCID iD
0000-0002-8456-9995
Google Scholar ID
https://scholar.google.com.br/citations?user=UJ6bS8QAAAAJ&hl=pt-PT&authuser=1
Scopus Author Id
35190948700

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2022/12
Concluded
 Aggregated in Health Sciences, Biomedicine (Título de Agregado)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2011 - 2011
Concluded
 Pos doctoral, Netherlands, Training on LC-MS methodologies (Pós-doutoramento)
Slotervaart Hospital - Department of Pharmacy & Pharmacology, Netherlands
2010/03/03 - 2010/09/06
Concluded
 USA, NCTR, Postdoctoral Training in Epigenetics/Toxicology (Pós-doutoramento)
National Center for Toxicological Research, United States
2006/01 - 2010/01/14
Concluded
 Pharmacology (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
"Monitorização das concentrações plasmáticas de efavirenz: critérios de aplicabilidade à prática clínica e efeitos do fármaco a longo termo/Therapeutic drug monitoring of Efavirenz: criteria and long-term drug effects" (THESIS/DISSERTATION)
 Maximal
2002 - 2002
Concluded
 Short-term formation - Quantification of drugs by HPLC (Outros)
Hospital Clínic de Barcelona, Spain
2001 - 2002
Concluded
 Graduation Thesis: Development and validation of a HPLC method to quantify efavirenz plasma concentration in HIV-infected patients (Outros)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2002
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
Affiliation

Science

Category
Host institution 		Employer
2011/03/01 - 2011/10/09 Postdoc (Research) MC Slotervaart, Netherlands
MC Slotervaart, Netherlands
2010/05/01 - 2010/08/06 Postdoc (Research) National Center for Toxicological Research, United States

Teaching in Higher Education

Category
Host institution 		Employer
2012 - 2022 Assistant Professor (University Teacher) Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Positions / Appointments

Category
Host institution 		Employer
2022/02 - Current Group Leader at Renal, Cardiovascular and Metabolic Pharmacology lab Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/01 - Current Head of Pharmacology 1 Integrated Master in Medicine Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - Current Coordinator of the Pedagogic Comission of the 2nd year of the Integrated Master Degree in Medicine Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - Current Vice-director of the PhD Program in Biomedicine Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - Current Responsible for the Analytical Facility Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - Current Coordinator of the Therapeutic Drug Monitoring Unit Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - 2022 Head of the Curricular Unit "General Pharmacology" of the Integrated Master degree in Medicine Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2021 Head of the Curricular Unit "Aging and chronic diseases: from molecular mechanisms to therapies" of the Master's Degree NOVA Biomedical Research Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Others

Category
Host institution 		Employer
2022 - Current Assistant Professor with aggregation in Health Sciences, Biomedicine Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021 - Current co-Group Leader at iNOVA4Health FCT Research Unit Cardiometabolic diseases Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019 - 2021 co-Group Leader Translational Pharmacology lab Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2006/10/02 - 2010/01/14 PhD student Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2002/10/01 - 2002/11/01 Research fellow Hospital Clínic de Barcelona, Spain
2001/10/01 - 2002/03/31 PRODEPT grant graduationThesis Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Projects

Grant

Designation Funders
2002 - 2003 Clinical efficacy and therapeutic drug monitoring of antiretroviral drugs in HIV infected patients taking rifamycins
POCTI/FCB/42664/2001
Research Fellow
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2001 - 2002 Development and validation of a HPLC method to quantify efavirenz plasma concentration in HIV-infected patients
PRODEPT
Research Fellow
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Concluded

Contract

Designation Funders
2023 - Current Mass spectrometry & Machine Learning pipeline to tackle Chronic Kidney Disease & Resistant Hypertension: a guide for patient subtyping & precision medicine
FCT 2022.06292.PTDC
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2021 - Current Muscle up with intermittent hypoxia: a matter of intensity, gender and metabolism
iNOVA4Health- IUDB/004462/2020/TL2/P2
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

iNOVA4Health, Portugal
iNOVA4Health

Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2021/09/30 AhR-CYP1A:1 linking environmental exposure and sleep apnea to improve arterial hypertension management
PTDC/MED-TOX/30418/2017
Principal investigator
Universidade Nova de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2021/09/30 Photonic biosensor for point of care and early diagnostics of acute kidney injury
PTDC/NAN-OPT/31311/2017
Researcher
Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal

Universidade Nova de Lisboa UNINOVA Instituto de Desenvolvimento de Novas Tecnologias, Portugal

Universidade Nova de Lisboa, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016 - 2020 Diagnosis, monitoring and prevention of exposure-related non-communicable diseases (DiMoPEx/CA15129)).
CA15129
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 European Cooperation in Science and Technology
Concluded
2017 - 2019 Efficacy of olive oil and phenolic compounds in reversing hypertension induced by chronic intermittent hypoxia
201707-05-30
iNOVA4Health, Portugal
 iNOVA4Health
Concluded
2016 - 2019 (per)Sulfidomics: benchmarking mechanisms underlying drug toxicity and drug resistance in precision medicine
UID/Multi/04462/2013
iN4H_201601-02-021
Principal investigator
iNOVA4Health, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2019 AhR: a therapeutic target for co-morbidities associated with chronic intermittent hypoxia
PAULIF
Researcher
Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior

Gouvernement francais Ministère de l'Enseignement supérieur de la Recherche et de l'Innovation
Concluded
2016 - 2018 (Clinical Trial) Variability of sulfotransferase 1A1 activity in humans: an approach to improve predictive drug response
2016-001395-29
NCT03182595:
Researcher
Hospital da Luz Lisboa, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Hospital da Luz Lisboa
Ongoing
2016 - 2018 Targeting monocytes as angiogenesis promoters in cancer- New application for old drugs
Inova4health 201707-05-35
Principal investigator
Concluded
2016 - 2017 Kidney tubular lesion in HIV patients
PGG/032/2015
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Gilead Sciences Lda
Concluded
2013/06/01 - 2016/12/31 From small bioactive molecules to an integrated OMICS approach: Mass Spectrometry tools for mechanistic insights into drug-like and functional properties, toxicity, and stress responses
RECI/QEQ-MED/0330/2012
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Centro Hospitalar de Lisboa Central EPE, Portugal

Hospital Professor Doutor Fernando Fonseca EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/03/18 - 2015/09/17 HivKIomics - new insights on tubular injury and nephrotoxicity diagnosis and prediction in HIV-infected patients
EXPL/DTP-FTO/1792/2013
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Hospital Professor Doutor Fernando Fonseca EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/04/01 - 2015/06/30 Point of care testing of cardiovascular disease markers - detection of homocystein-thiolactone
EXPL/DTP-PIC/1758/2013
Researcher
Egas Moniz Cooperativa de Ensino Superior CRL, Portugal

Centro de Investigação Interdisciplinar Egas Moniz, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015 HIV nefromics: new markers of nephrotoxicity induced by antiretrovirals in hiv+ patients
SPN2013
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Sociedade Portuguesa de Nefrologia
2012 - 2015 Zebrafish as a biomedical tool to evaluate drug toxicity
FCG121986
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação Calouste Gulbenkian
Concluded
2013/11/02 - 2014/11/01 TeachIng an olD drug nEw tricks: re-profiling An anti-HIV drug as an HDL modulator
EXPL/DTP-FTO/0204/2012
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Centro Hospitalar de Lisboa Central EPE, Portugal

Hospital Professor Doutor Fernando Fonseca EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/03/15 - 2014/09/14 Hepatic toxicity in HIV-infected individuals exposed to nevirapine
PTDC/SAU-TOX/111663/2009
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Centro Hospitalar de Lisboa Central EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2013 Bioactivation routes of the anti - HIV drug Nevirapine: identification of reactive metabolites and mutagenic potential
PTDC/QUI-QUI/113910/2009
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2002 - 2004 Implementation of a laboratory for therapeutic drug monitoring of antiretroviral drugs in HIV infected patients
CNLCS2002
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Clara Gonçalves-Dias; Catarina O. Sequeira; João Vicente; M. João Correia; Nuno R. Coelho; Judit Morello; AMM Antunes; et al. "A Mechanistic-Based and Non-invasive Approach to Quantify the Capability of Kidney to Detoxify Cysteine-Disulfides". 109-120. Springer, 2021.
    10.1007/978-3-030-63908-2_8
  2. João Filipe Raposo; José A. Belo; Sílvia V. Conde; Monteiro, EC; José Silva Nunes; Pereira, Sofia A.; Gabriela A. Silva; Maria Paula Macedo. "B From a classical to a new nova perspective on cardiometabolic diseases". In From Life Molecules to Global Health, 261-290. PRINCIPIA, 2021.
    Published
  3. Coelho, Nuno R.; Dias, Clara G.; João Correia, M.; Grácio, Patrícia; Serpa, Jacinta; Monteiro, Emília C.; Diogo, Lucília N.; Pereira, Sofia A.. "Cysteine Oxidative Dynamics Underlies Hypertension and Kidney Dysfunction Induced by Chronic Intermittent Hypoxia". In Advances in Experimental Medicine and Biology, 83-88. Springer International Publishing, 2018.
    10.1007/978-3-319-91137-3_10
  4. Pereira, Sofia A.; Wanke, Riccardo; Marques, M. Matilde; Monteiro, Emília C.; Antunes, Alexandra M.M.. "Insights into the Role of Bioactivation Mechanisms in the Toxic Events Elicited by Non-nucleoside Reverse Transcriptase Inhibitors". In Advances in Molecular Toxicology Volume 6, 1-39. Elsevier, 2012.
    10.1016/b978-0-444-59389-4.00001-x
  5. Pereira, Sofia A.. "HDL in HIV infection: the effect of the antiretroviral efavirenz on HDL-quality and quantity.". In Advances in medicine and biology. Nova Science Publishers, Inc, 2012.
    Published
  6. "Understanding the Molecular Basis for the Hazards Associated with Nevirapine Treatment, in: L.V". In Advances in Medicine and Biology. NovaPublishers, 2012.
    Published
Conference abstract
  1. Pereira, Sofia. "The antihypertensive effect of ahr antagonist is related to circadian variation of blood pressure in chronic intermittent hypoxia condition [oral presentation]". Paper presented in L Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVIII Reunião de Farmacologia Clínica/ XIX Reunião de Toxicologia, Coimbra, 2020.
  2. Pereira, Sofia. "Hydroxytyrol prevents increase in systolic blood pressure induced by chronic intermittent hypoxia [oral presentation]". Paper presented in XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVII Reunião de Farmacologia Clínica/ XVIII Reunião de Toxicologia, Porto, 2019.
  3. Pereira, Sofia. "Pharmacological blocking of AhR reduces hypertension induced by chronic intermittent hypoxia [oral presentation]". Paper presented in XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVII Reunião de Farmacologia Clínica/ XVIII Reunião de Toxicologia, Porto, 2019.
  4. Pereira, Sofia. "Urinary mercapturates of cysteine-disulfides decrease in models of drug-induced acute kidney injury [oral presentation]". Paper presented in XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVII Reunião de Farmacologia Clínica/ XVIII Reunião de Toxicologia, Porto, 2019.
  5. Pereira, Sofia. "Metabolomics of drug-induced renal injury in zebrafish larvae. [oral presentation]". Paper presented in XLVII meeting of thePortuguese Society of Pharmacology, 2018.
  6. Pereira, Sofia. "Enzymes involved in cysteine metabolism underlie hypoxia adaptation in ovarian cancer [oral presentation]". Paper presented in 8th International conference on Tumor Microenvironment, 2018.
    10.1007/s12307-018-0212-6
  7. Pereira, Sofia. "Mercapturatos de dissulfetos de cisteína como marcadores de progressão de doença renal: comparação entre dois modelos animais de pré-diabetes [oral presentation]". Paper presented in 14º Congresso Português de Diabetes (Rev Port Diab 2018, 13(1) Suppl:37-40), 2018.
  8. Pereira, Sofia. "AhR: linking environmental exposure and sleep apnea to improve arterial hypertension management [oral presentation]". Paper presented in I NoTeS Congress – Novel Therapeutic Strategies for Noncommunicable Diseases, Porto, 2018.
  9. Pereira, Sofia. "Cysteine disulfide stress is a common mechanism in kidney injury associated to metabolic inflammation models [oral communication]". Paper presented in XXXI Congresso Português de Nefrologia, Vilamoura, 2018.
  10. Pereira, Sofia. "Cysteine oxidative dynamics underlies hypertension and kidney dysfunction induced by chronic intermittent hypoxia [oral presentation]". Paper presented in XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVI Reunião de Farmacologia Clínica/ XVII Reunião de Toxicologia, Lisbon, 2018.
  11. Pereira, Sofia. "AhR metabolic pathway in hypertension induced by chronic intermittent hypoxia [oral presentation]". Paper presented in XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVI Reunião de Farmacologia Clínica/ XVII Reunião de Toxicologia, Lisbon, 2018.
  12. Pereira, Sofia. "Effect of chronic intermittent hypoxia in the temporal variation of mercapturates of cysteineS-disulfides [oral presentation]". Paper presented in XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVI Reunião de Farmacologia Clínica/ XVII Reunião de Toxicologia, Lisbon, 2018.
  13. Pereira, Sofia. "Is zebrafish a good model to assess drug-induced renalinjury? [inivited oral presentation]". Paper presented in 3rd InternationalConference on Urine Omics and 2nd International Caparica Conference inTranslational Nephrology, 2017.
  14. Pereira, Sofia. "Comparison of a marker of kidney disease progression between two animal models of pre-diabetes [oral presentation]". Paper presented in Renal disease in obesity and diabetes. Advances in pathogenesis and therapeutics – Diabesity Working Group, Lisbon, 2017.
  15. Pereira, Sofia. "Cysteine oxidation in kidney: the effect of short and long-term exposure to chronic intermittent hypoxia [1 minute elevator talk]". Paper presented in EMBO Workshop: Thiol oxidation in toxicity and signaling, Sant Feliu de Guïxols, 2017.
  16. Pereira, Sofia. "Cysteine oxidation in the underlying mechanisms of kidney fibrosis induced by chronic intermittent hypoxia [oral presentation]". Paper presented in XXth Meeting of the International Society of Arterial Chemoreception (ISAC), Baltimore, 2017.
  17. Pereira, Sofia. "S-thiolated protein profile is influenced by efavirenz [oral presentation]". Paper presented in XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXV Reunião de Farmacologia Clínica/ XVI Reunião de Toxicologia, Coimbra, 2017.
  18. Pereira, Sofia. "Temporal and tissue dependent effects of Efavirenz exposure: implications for its neurotoxicity [oral presentation]". Paper presented in XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXV Reunião de Farmacologia Clínica/ XVI Reunião de Toxicologia, Coimbra, 2017.
  19. Pereira, Sofia. "uNAC as a novel marker of kidney disease progression in HIV-patients [oral presenation]". Paper presented in XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXV Reunião de Farmacologia Clínica/ XVI Reunião de Toxicologia, Coimbra, 2017.
  20. Pereira, Sofia. "Kidney cysteine redox cycle in rats exposed to chronic intermittent hypoxia [oral presentation]". Paper presented in XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXV Reunião de Farmacologia Clínica/ XVI Reunião de Toxicologia, Coimbra, 2017.
  21. Pereira, Sofia. "Molecular targeting of proteins by homocysteine in hypercholesterolemia [oral presentation]". Paper presented in . XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXIII Reunião de Farmacologia Clínica/ XV Reunião de Toxicologia, 2016.
  22. Pereira, Sofia. "Modulation of paraoxonase-1 by nevirapine: comparison between three in vitro models [oral presentation]". Paper presented in XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXIII Reunião de Farmacologia Clínica/ XV Reunião de Toxicologia, 2016.
  23. Pereira, Sofia. "Urinary N-acetylated cysteine-disulfides as indicators of kidney disease progression in HIV-infected patients [oral presentation]". Paper presented in 7th European Congress of Pharmacology (EPHAR), 2016.
  24. Pereira, Sofia. "Efavirenz biotransformation at the onset of mood changes in HIV-infected male patients [oral presentation]". Paper presented in XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXIV Reunião de Farmacologia Clínica/ XV Reunião de Toxicologia, Porto, 2016.
  25. Pereira, Sofia. "Monitoring glomerular function in zebrafish larvae (Danio rerio) exposed to nephrotoxic drugs. [oral presentation]". Paper presented in XLV meeting of the Portuguese Society of Pharmacology, 2015.
  26. Pereira, Sofia. "The role of Nevirapine phase I metabolites in the renal function of HIV-infected patients [oral presentation]". Paper presented in 1st International Caparica Conference in Translational Nephrology & 18th Portuguese Symposium on Renal Diseases, 2014.
  27. Pereira, Sofia. "Antivíricos diretos e imunossupressores: interações [invited oral presentation]". Paper presented in Workshop Hepatite C - Inovação Farmacologia e Transplantação, 2014.
  28. Pereira, Sofia A.. "Thiol status in HIV-infected patients: the effect of nevirapine metabolism.". 2014.
    DOI: 10.1016/j.toxlet.2014.06.352
  29. Pereira, Sofia A.. "PON-1 activity as a protective player in nevirapine hepatotoxicity: data comparison in 2D and 3D cell cultures.". 2014.
    DOI: 10.1016/j.toxlet.2014.06.476
  30. Pereira, Sofia A.. "Paraoxonase as part of endogenous free-radical scavenging system in zebrafish". 2014.
    DOI: 10.1016/j.toxlet.2014.06.185
  31. Pereira, Sofia A.; Inês Varanda de Jesus Faustino; Lucilia Diogo; Ricardo A. Afonso; Pereira SA; E.C. Monteiro; Ana Isabel Santos. "Oral voluntary ingestion as a stress free alternative to orogastric gavage: The example of losartan chronic administration.". 2014.
    DOI: 10.1016/j.toxlet.2014.06.572
  32. Pereira, Sofia A.. "3D hepatocyte cultures: A useful tool in the study of Nevirapine bioactivation and toxicity.". Paper presented in 49th Congress of the European Societies of Toxicology (EUROTOX), 2013.
  33. Pereira, Sofia. "Relevance of CYP2C19 genotypes in Nevirapine biotransformation [oral presentation]". Paper presented in European Society of Pharmacogenomics and Theranostics (ESPT) Second Conference. Pharmacogenomics: from Cell to Clinic, 2013.
  34. Pereira, Sofia. "Effect of chronic exposure to the antiretroviral drug nevirapine on paraoxonase-1 activities in HIV-infected patients [oral presentation]". Paper presented in 2nd International Conference on Occupational & Environmental Toxicology, 2013.
  35. Pereira, Sofia. "Biomedical models for translational research [invited oral presentation]". Paper presented in 3º Congresso Internacional de Enfermagem Veterinária, 2013.
  36. Pereira SA; E.C. Monteiro. "Hemoglobin adducts from the antiretroviral abacavir in HIV-infected patients as evidence of bioactivation [oral presentation]". Paper presented in 244th ACS National Meeting & Exposition, Philadelphia, 2012.
  37. Pereira, Sofia. "Antiretrovirals and Cardiovascular disease [invited oral presentation]". Paper presented in Santa Marta Lisbon Summer Meeting, 2012.
Conference paper
  1. Gracio, Patricia C.; Goncalves-Dias, Clara; Lopes-Coelho, Filipa; Monteiro, Emilia C.; Serpa, Jacinta; da Silva, Claudia L.; Pereira, Sofia A.. "Changes in N-acetyltransferase 8 in kidney tubular cell: injury, recovery and mesenchymal stromal cell-based therapy". 2019.
    10.1109/enbeng.2019.8692517
  2. Pereira, Sofia; Pereira SA; Pereira, Sofia A.. "Epigenetic Markers of Hepatotoxicity: A Nevirapine Story". Paper presented in 41st Annual Meeting of Environmental-Mutagen-Society, 2010.
    https://doi.org/10.1002/em.20625
  3. Pereira SA; RM Corte-Real; T Branco; F Lampreia; I Germano; U Caixas; E.C. Monteiro. "Efavirenz plasma concentrations - Is gender important?". 2004.
Conference poster
  1. Marto, Natália; Morello, Judit; Antunes, AMM; Monteiro, EC; Pereira, Sofia A.. "Phenotyping SULT in Man: a Simple Metric Using Paracetamol as Probe". Paper presented in ASPET Annual Meeting at EB 2021, 2021.
  2. Correia, M João; Coelho, Nuno; Elsa Mecha; Sandra Silva; Bronze, Maria; Monteiro, EC; Pereira, Sofia A.. "Olive oil and arterial hypertension (htn): a focus on hydroxytyrosol". Paper presented in II Conference NOVASaude Nutrition, 2021.
  3. Branco, Patrícia; Martins, Ana Rita Mateus; Coelho, Rita Alexandre; Pinto, Daniel G; Mateus, Catarina; Calça, Rita; Sequeira CO; Morello, Judit; Pereira, Sofia A.. "A Pilot Evaluation of Thiol Metabolome in Peritoneal Dialysate as an Indicator of Peritoneal Fibrosis (PO1247)". Paper presented in Kidney Week 2020, 2020.
  4. Fernandes D.G.H.; Coelho N.R.; Correia, M João; Tomé C.S.; Sequeira CO; Monteiro, EC; Matias P.M.; Pereira, Sofia A.; Vicente, João B.. "The six W´s of protein cysteinylation in the kidney.". Paper presented in 10th ITQB NOVA PhD Students Meeting, 2020.
  5. Judit Morello; Sara M. Teixeira; Joao Rodrigues; Sara Maia; Atlas Sardoo; Rita Pinheiro Torres; Pereira SA; et al. "Diagnosis of Inflammatory Rheumatic Diseases: Preliminary Approach by Urine Metabolomics". Paper presented in Annual Meeting of the American College of Rheumatology, 2019.
  6. Pereira, Sofia. "Blockade of AhR reverts systemic hypertension induced by chronic intermittent hypoxia in rats". Paper presented in AhR Meeting, Paris, France, 2018.
  7. Pereira, Sofia. "Renal cysteine-disulfide stress is a common feature of cardiometabolic diseases". Paper presented in I NoTeS Congress – Novel Therapeutic Strategies for Noncommunicable Diseases, Porto, Portugal, 2018.
  8. Pereira, Sofia. "Mercapturates of cysteine-S-disulfides in kidney dysfunction in HIV-infection". Paper presented in 1st Workshop on Human Biomonitoring in Portugal (1st HBM-PT), Lisbon, Portugal, 2018.
  9. Pereira, Sofia. "Mercapturates of cysteine-S-disulfides for risk assessment of exposure-related hypertension and kidney dysfunction". Paper presented in DiMoPEx Working Groups Meeting, 2nd International conference on Pollution in living and working environments and health, Bentivoglio, Italy, 2017.
    https://www.journalhealthpollution.org/doi/pdf/10.5696/2156-9614.8.17.1
  10. Pereira, Sofia. "Mercapturate pathway and kidney disease progression in HIV-patients: a 1-year prospective study". Paper presented in ISN World Congress of Nephrology 2017, México., 2017.
  11. Nádia Grilo; Maria Correia; Catarina Sequeira; Shrika G Harjivan; Umbelina Caixas; Lucilia Diogo; M Matilde Marques; et al. "Monitoring of 8-hydroxy-efavirenz concentrations for management of mood changes". Paper presented in International Congress of Drug Therapy in HIV Infection, Glasgow, 2016.
    http://dx.doi.org/10.7448/IAS.19.8.21487
  12. Pereira, Sofia. "S-protein thiol-omics to assess the redox-modulation effects of antiretroviral drugs". Paper presented in International Congress of Drug Therapy in HIV Infection, Glasgow, 2016.
    10.7448/IAS.19.8.21487
Journal article
  1. Fernandes, Joana L.; Martins, Fátima O.; Olea, Elena; Prieto-Lloret, Jesus; Braga, Patrícia C.; Sacramento, Joana F.; Sequeira, Catarina O.; et al. "Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation". Antioxidants 12 11 (2023): 1910. http://dx.doi.org/10.3390/antiox12111910.
    Published • 10.3390/antiox12111910
  2. Martins, Ana Rita; Azeredo-Lopes, Sofia; Pereira, Sofia Azeredo; Moreira, Inês; Weigert, André Luíz. "Klotho and lean mass as novel cardiovascular risk factors in hemodialysis patients". Clinical Kidney Journal 16 12 (2023): 2587-2596. http://dx.doi.org/10.1093/ckj/sfad166.
    Published • 10.1093/ckj/sfad166
  3. Baltazar, Pedro; de Melo Junior, Antonio Ferreira; Fonseca, Nuno Moreira; Lança, Miguel Brito; Faria, Ana; Sequeira, Catarina O.; Teixeira-Santos, Luísa; et al. "Oxalate (dys)Metabolism: Person-to-Person Variability, Kidney and Cardiometabolic Toxicity". Genes 14 9 (2023): 1719. http://dx.doi.org/10.3390/genes14091719.
    Published • 10.3390/genes14091719
  4. Dias-Carvalho, Ana; Margarida-Araújo, Ana; Reis-Mendes, Ana; Sequeira, Catarina Oliveira; Pereira, Sofia Azeredo; Guedes de Pinho, Paula; Carvalho, Félix; et al. "A Clinically Relevant Dosage of Mitoxantrone Disrupts the Glutathione and Lipid Metabolic Pathways of the CD-1 Mice Brain: A Metabolomics Study". International Journal of Molecular Sciences 24 17 (2023): 13126. http://dx.doi.org/10.3390/ijms241713126.
    Published • 10.3390/ijms241713126
  5. Zhang, Junmin; Wang, Rong; Pereira, Sofia Azeredo. "Editorial: Drug metabolism and transport: the Frontier of personalized medicine". Frontiers in Pharmacology 14 (2023): http://dx.doi.org/10.3389/fphar.2023.1246827.
    Published • 10.3389/fphar.2023.1246827
  6. Pimpão, António; Sousa, Cátia; Correia, M João; Coelho, Nuno; Monteiro, EC; Melo Junior, AF; Pereira, Sofia A.. "Control of Arterial Hypertension by the AhR Blocker CH-223191: A Chronopharmacological Study in Chronic Intermittent Hypoxia Conditions". Advances in Experimental Medicine and Biology 147 (2023):
    Published • https://doi.org/10.1007/978-3-031-32371-3_4
  7. Pepe, Bruno; Prazeres, Teresa; Carnevale, Andreia; Calça, Rita; Matias, Patricia; Branco, Patricia; Azeredo-Lopes, Sofia; Pereira, Sofia Azeredo; Martins, Ana Rita. "#3546 “SURPRISE QUESTION”: IS IT A USEFUL TOOL IN CKD STAGES 4 TO 5?". Nephrology Dialysis Transplantation 38 Supplement (2023): http://dx.doi.org/10.1093/ndt/gfad063c_3546.
    Published • 10.1093/ndt/gfad063c_3546
  8. Mauricio, Miguel Nuno Petrucci; Merino, Jaime Hernán; Carnevale, Andreia; Pereira, Sofia Azeredo; Martins, Ana Rita; Calça, Rita; Matias, Patricia; et al. "#2674 ASSOCIATION BETWEEN SARCOPENIA, BODY COMPOSITION AND FRAILTY IN PERITONEAL DIALYSIS PATIENTS: A MULTI-CENTRIC STUDY". Nephrology Dialysis Transplantation 38 Supplement (2023): http://dx.doi.org/10.1093/ndt/gfad063b_2674.
    Published • 10.1093/ndt/gfad063b_2674
  9. Branco, Patrícia; Calça, Rita; Martins, Ana Rita; Mateus, Catarina; Jervis, Maria João; Gomes, Daniel Pinto; Azeredo-Lopes, Sofia; et al. "Fibrosis of Peritoneal Membrane, Molecular Indicators of Aging and Frailty Unveil Vulnerable Patients in Long-Term Peritoneal Dialysis". International Journal of Molecular Sciences 24 5 (2023): 5020. http://dx.doi.org/10.3390/ijms24055020.
    10.3390/ijms24055020
  10. Branco, Patrícia; Martins, Ana Rita; Calça, Rita; Mateus, Catarina; Jervis, Maria João; Rodrigues, Anabela; Lopes, Sofia Azeredo; et al. "Alpha-klotho and peritoneal membrane status: A hypothesis generating study". European Journal of Clinical Investigation 53 3 (2022): http://dx.doi.org/10.1111/eci.13903.
    10.1111/eci.13903
  11. Lopes-Coelho, Filipa; Martins, Filipa; Hipólito, Ana; Conde, Sílvia V.; Pereira, Sofia A.; Gonçalves, Luís G.; Serpa, Jacinta. "A Metabolic Signature to Monitor Endothelial Cell Differentiation, Activation, and Vascular Organization". Biomedicines 10 9 (2022): 2293. http://dx.doi.org/10.3390/biomedicines10092293.
    10.3390/biomedicines10092293
  12. Filipa Lopes-Coelho; Sofia Nunes; Filipa Martins; Ana Hipolito; Sofia Gouveia-Fernandes; Germana Domingues; Bernardete F. Melo; et al. "Propranolol therapy for cerebral cavernous malformations". World Academy of Sciences Journal 4 3 (2022): https://novaresearch.unl.pt/en/publications/2de56f91-0662-4c59-94ee-de2b4003af30.
    10.3892/wasj.2022.158
  13. Correia, Maria João; Pimpão, António B.; Fernandes, Dalila G. F.; Morello, Judit; Sequeira, Catarina O.; Calado, Joaquim; Antunes, Alexandra M. M.; et al. "Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine". Molecules 27 4 (2022): 1416. http://dx.doi.org/10.3390/molecules27041416.
    Published • 10.3390/molecules27041416
  14. Carecho, Rafael; Figueira, Inês; Terrasso, Ana Paula; Godinho-Pereira, Joana; de Oliveira Sequeira, Catarina; Pereira, Sofia Azeredo; Milenkovic, Dragan; et al. "Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease". Molecular Nutrition & Food Research (2021): 2100959. http://dx.doi.org/10.1002/mnfr.202100959.
    10.1002/mnfr.202100959
  15. Coelho, N. R.; Pimpão, A. B.; Correia, M. J.; Rodrigues, T. C.; Monteiro, E. C.; Morello, J.; Pereira, S. A.. "Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence". Journal of Molecular Medicine 100 2 (2021): 215-243. http://dx.doi.org/10.1007/s00109-021-02163-2.
    Published • 10.1007/s00109-021-02163-2
  16. Correia, Maria João; Pimpão, António B.; Lopes-Coelho, Filipa; Sequeira, Catarina O.; Coelho, Nuno R.; Gonçalves-Dias, Clara; Barouki, Robert; et al. "Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex". Antioxidants 10 9 (2021): 1484. http://dx.doi.org/10.3390/antiox10091484.
    Published • 10.3390/antiox10091484
  17. Nunes, Sofia C.; Ramos, Cristiano; Santos, Inês; Mendes, Cindy; Silva, Fernanda; Vicente, João B.; Pereira, Sofia A.; et al. "Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.722412.
    Published • 10.3389/fcell.2021.722412
  18. Filipa Lopes-Coelho; Filipa Martins; Ana Hipólito; Cindy Mendes; Catarina O. Sequeira; Rita F. Pires; António Almeida; et al. "The Activation of Endothelial Cells Relies on a Ferroptosis-Like Mechanism". Frontiers in Oncology 11 (2021): https://novaresearch.unl.pt/en/publications/8dcd8bcd-4c56-4a7a-88bb-98f7cbb92a78.
    10.3389/fonc.2021.656229
  19. Marto, Natalia; Morello, Judit; Antunes, Alexandra; Monteiro, Emília; Pereira, Sofia. "Phenotyping SULT in Man: a Simple Metric Using Paracetamol as Probe". The FASEB Journal 35 S1 (2021): http://dx.doi.org/10.1096/fasebj.2021.35.s1.03064.
    Published • 10.1096/fasebj.2021.35.s1.03064
  20. Marto, Natália; Morello, Judit; Antunes, Alexandra M. M.; Azeredo, Sofia; Monteiro, Emília C.; Pereira, Sofia A.. "A simple method to measure sulfonation in man using paracetamol as probe drug". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-88393-3.
    10.1038/s41598-021-88393-3
  21. Pereira, Sofia A.; Filipa Lopes-Coelho; Filipa Martins; Ana Hipólito; Cindy Mendes; Catarina O. Sequeira; Rita F Pires; et al. "The activation of endothelial cells relies on a ferroptosis-like mechanism: novel perspectives in management of angiogenesis and cancer therapy". Frontiers in Oncology 11 1666 (2021):
  22. Filipa Lopes-Coelho; Filipa Martins; Sofia A. Pereira; Jacinta Serpa. "Anti-Angiogenic Therapy: Current Challenges and Future Perspectives". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22073765.
    10.3390/ijms22073765
  23. Pereira, Sofia A.; Harjivan, Shrika G; Charneira, Catarina; Martins, Inês L; Espadas, Guadalupe; Sabidó, Eduard; Beland, Frederick A; Marques, M. Matilde; Antunes, Alexandra M.M.. "Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine". Molecules 2021 26 5 (2021): 1349-1349. https://doi.org/10.3390/molecules26051349.
    Published • 10.3390/molecules26051349
  24. Célia M. Silveira; Patrícia R. Rodrigues; Wissam Ghach; Sofia A. Pereira; Francisco Esteves; Michel Kranendonk; Mathieu Etienne; M. Gabriela Almeida. "Electrochemical Activity of Cytochrome P450 1A2: The Relevance of O 2 Control and the Natural Electron Donor". ChemElectroChem 8 3 (2021): 500-507. https://doi.org/10.1002/celc.202001255.
    10.1002/celc.202001255
  25. Célia M. Silveira; Patrícia R. Rodrigues; Wissam Ghach; Sofia A. Pereira; Francisco Esteves; Michel Kranendonk; Mathieu Etienne; M. Gabriela Almeida. "Front Cover: Electrochemical Activity of Cytochrome P450 1A2: The Relevance of O 2 Control and the Natural Electron Donor (ChemElectroChem 3/2021)". ChemElectroChem 8 3 (2021): 425-425. https://doi.org/10.1002/celc.202001616.
    10.1002/celc.202001616
  26. Coelho, Nuno R.; Matos, Clara; Pimpão, António B.; Correia, M. João; Sequeira, Catarina O.; Morello, Judit; Pereira, Sofia A.; Monteiro, Emília C.. "AHR canonical pathway: in vivo findings to support novel antihypertensive strategies". Pharmacological Research (2021): 105407. http://dx.doi.org/10.1016/j.phrs.2020.105407.
    Published • 10.1016/j.phrs.2020.105407
  27. Marinho, Aline T.; Batuca, Joana R.; Miranda, Joana P.; Caixas, Umbelina; Dias, Clara G.; Branco, Teresa; Soto, Karina; et al. "The 2-hydroxy-nevirapine metabolite as a candidate for boosting apolipoprotein A1 and for modulating anti-HDL antibodies". Pharmacological Research (2021): 105446. http://dx.doi.org/10.1016/j.phrs.2021.105446.
    10.1016/j.phrs.2021.105446
  28. Bonifácio, Vasco D. B.; Pereira, Sofia A.; Serpa, Jacinta; Vicente, João B.. "Cysteine metabolic circuitries: druggable targets in cancer". British Journal of Cancer (2020): http://dx.doi.org/10.1038/s41416-020-01156-1.
    Published • 10.1038/s41416-020-01156-1
  29. Nuno R. Coelho; Céline Tomkiewicz; M. João Correia; Clara Gonçalves-Dias; Robert Barouki; Pereira SA; Xavier Coumoul; E.C. Monteiro. "First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia". Pharmacological Research 159 (2020): https://novaresearch.unl.pt/en/publications/c9eadc82-d6c7-4742-9746-a0becd09e55e.
    10.1016/j.phrs.2020.104869
  30. Gomes, A.; Godinho-Pereira, J.; Oudot, C.; Sequeira, C.O.; Macià, A.; Carvalho, F.; Motilva, M.J.; et al. "Berry fruits modulate kidney dysfunction and urine metabolome in Dahl salt-sensitive rats". Free Radical Biology and Medicine 154 (2020): 119-131. http://dx.doi.org/10.1016/j.freeradbiomed.2020.05.002.
    10.1016/j.freeradbiomed.2020.05.002
  31. Madalena Cipriano; Pedro F Pinheiro; Catarina O Sequeira; Joana S Rodrigues; Nuno G Oliveira; Alexandra M M Antunes; Matilde Castro; et al. "Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and Glutathiolomic Profile of a Human Hepatocyte-Like Cell 3D Model". International Journal of Molecular Sciences 21 11 (2020): 3998-3998. https://doi.org/10.3390/ijms21113998.
    10.3390/ijms21113998
  32. Lopes-Coelho, Filipa; Silva, Fernanda; Gouveia-Fernandes, Sofia; Martins, Carmo; Lopes, Nuno; Domingues, Germana; Brito, Catarina; et al. "Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis". Cells 9 1 (2020): 107. http://dx.doi.org/10.3390/cells9010107.
    10.3390/cells9010107
  33. Santos, Inês; Ramos, Cristiano; Mendes, Cindy; Sequeira, Catarina O.; Tomé, Catarina S.; Fernandes, Dalila G.H.; Mota, Pedro; et al. "Targeting Glutathione and Cystathionine ß-Synthase in Ovarian Cancer Treatment by Selenium–Chrysin Polyurea Dendrimer Nanoformulation". Nutrients 11 10 (2019): 2523. http://dx.doi.org/10.3390/nu11102523.
    10.3390/nu11102523
  34. Pereira; Antunes. "Special Issue "Adductomics: Elucidating the Environmental Causes of Disease"". High-Throughput 8 3 (2019): 17. http://dx.doi.org/10.3390/ht8030017.
    10.3390/ht8030017
  35. Gonçalves-Dias; Morello; Semedo; Correia; Coelho; Monteiro; Antunes; et al. "The mercapturomic profile of health and non-communicable diseases". High-Throughput 8 2 (2019): 10. http://dx.doi.org/10.3390/ht8020010.
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  36. Nunes; Charneira; Morello; Rodrigues; Pereira; Antunes; Nunes, Joao; et al. "Mass Spectrometry-Based Methodologies for Targeted and Untargeted Identification of Protein Covalent Adducts (Adductomics): Current Status and Challenges". High-Throughput 8 2 (2019): 9. http://dx.doi.org/10.3390/ht8020009.
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  37. Aline T. Marinho; Joana P. Miranda; Umbelina Caixas; Catarina Charneira; Clara Gonçalves-Dias; M. Matilde Marques; Emília C. Monteiro; Alexandra M. M. Antunes; Sofia A. Pereira. "Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity". Drug Metabolism Reviews (2019): 1-15. https://doi.org/10.1080/03602532.2019.1577891.
    10.1080/03602532.2019.1577891
  38. Gonçalves-Dias, Clara; Morello, Judit; Correia, M. João; Coelho, Nuno R.; Antunes, Alexandra M.M.; Macedo, Maria Paula; Monteiro, Emília C.; Soto, Karina; Pereira, Sofia A.. "Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease". Nephron 143 1 (2019): 17-23. http://dx.doi.org/10.1159/000494390.
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  39. Figueiredo, Ines Carreira; Cargaleiro, Ines; Mueller, Stephanie; Aguiar, Pedro; Batuca, Joana R.; Pereira, Sofia Azeredo; Diogo, Lucilia; Ureche-Angelescu, Ilinca; Monteiro, Emilia C.. "PLATELET-LYMPHOCYTE RATIO AS A SHORT-TERM TREATMENT-RESPONSE PREDICTOR IN SCHIZOPHRENIA'S RELAPSE". Schizophrenia Bulletin (2019): https://publons.com/publon/28485534/.
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  40. Pereira, Sofia A.; Marinho AT; Lu H; Pereira SA; Monteiro E; Gabra H; Recchi C. "Anti-tumorigenic and Platinum-Sensitizing Effects of Apolipoprotein A1 and Apolipoprotein A1 Mimetic Peptides in Ovarian Cancer". Frontiers in Pharmacology (2019): https://publons.com/publon/20372505/.
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  42. Charneira, C.; Pereira, S. A.; Antunes, A. M. M.; C. Charneira; Pereira SA; A. M. M. Antunes. "Biomarkers of exposure to estrogen-derived reactive metabolites: mass spectrometry-based methodologies to identify protein covalent adducts". Toxicology Letters (2019): https://publons.com/wos-op/publon/47267032/.
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Magazine article
  1. Pereira, Sofia A.; Pereira, Sofia. "Estudos de iniciativa do investigador nas estratégias de otimização terapêutica.", Revista "O Hospital", 2017, https://issuu.com/apdhpublicacoes/docs/revista-hospital-x.
Online resource
  1. Pereira, Sofia. Zebrafish is an attractive model to anticipate drug-induced renal injury in humans.. 2018. https://atlasofscience.org/zebrafish-is-an-attractive-model-to-anticipate-drug-induced-renal-injury-in-humans/.
Thesis / Dissertation
  1. Pereira, Sofia de Azeredo. "Drug Monitoring of Efavirenz -applicability criteria and long-term pharmacokinetic/pharmacodynamic relations". PhD, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2009. http://hdl.handle.net/10362/5210.

Intellectual property

Patent
  1. Pereira, Sofia A.; Maria Emilia Carreira Saraiva Monteiro (5918-54A6-FAA0); Aline Teixeira Marinho. 2019. "2-hydroxy-nevirapine analogues or derivatives for use in the treatment of diseases related to high density lipoprotein dysfunction. PPI 2019/20066".

Other

Other output
  1. Association Between Sarcopenia, Body Composition and Frailty in Peritoneal Dialysis Patients. A Multi-centric Study. 2023. MNP Mauricio; JH Merino; A Carnevale; Pereira SA; AR Martins; R Calça; P Matias; et al. https://novaresearch.unl.pt/en/publications/6b8ce74c-378b-4637-9ec0-c8c793d43f26.
  2. "surprise Question". Is It a Useful Tool in Ckd Stages 4 to 5?. 2023. B Pepe; T Prazeres; A Carnevale; R Calca; P Matias; P Branco; Sofia Mucharreira de Azeredo Lopes; Pereira SA; AR Martins. https://novaresearch.unl.pt/en/publications/c5708652-627f-428a-a4b6-ae62ba4053fa.
  3. Aryl hydrocarbon receptor antagonists - a new entry in antihypertensive armamentarium of obstructive sleep apnea?. 2021. Pereira SA; Nuno R. Coelho; Celine Tomkiewcz; Maria Joao Correia; Antonio B. Pimpao; Robert Barouki; Xavier Coumoul; et al. https://novaresearch.unl.pt/en/publications/53cdf1c1-8bfa-4732-8d69-e835b48bc6ce.
  4. Platelet-lymphocyte ratio as a short-term treatment-response predictor in schizophrenia's relapse. 2019. Ines Carreira Figueiredo; Ines Cargaleiro; Stephanie Mueller; Aguiar P.; Joana R Batuca; Pereira SA; Lucilia Diogo; Ilinca Ureche-Angelescu; E.C. Monteiro. https://novaresearch.unl.pt/en/publications/6527fc22-da62-4659-b971-73837deba614.
  5. KIDNEY DISEASE PROGRESSION IN HIV-INFECTED PATIENTS RELATED WITH THE DETOXIFICATION OF ENDOGENOUS ELECTROPHILIC SPECIES. 2017. Clara Dias; Pedro Campos; Lucilia Diogo; Diva Trigo; Maria Joao Correia; Ana Lemos; E.C. Monteiro; Karina Soto; Pereira SA. https://novaresearch.unl.pt/en/publications/c0be8f8e-d7bc-42e4-b0a4-96dc01936af1.
  6. Monitoring of 8-hydroxy-efavirenz concentrations for management of mood changes. 2016. Nádia Grilo; Maria Correia; Catarina Sequeira; Shrika G Harjivan; Umbelina Caixas; Lucilia Diogo; M Matilde Marques; et al. https://novaresearch.unl.pt/en/publications/d64cf9ee-431f-450a-bb5c-006a503625a9.
  7. IS THERE A ROLE FOR SOLUBLE alpha-KLOTHO IN KIDNEY AND IMMUNE DYSFUNCTION OF HIV-INFECTEDPATIENTS?. 2016. Pedro Campos; Clara G Dias; Sara Maia; Pereira SA; Ana Pires; Karina Soto. https://novaresearch.unl.pt/en/publications/44bffc04-8162-4488-917c-efcadf40539d.
  8. Sex differences in hepatic and intestinal contributions for nevirapine biotransformation. 2014. Aline Teixeira Marinho; Pereira SA; Pereira, Sofia. https://novaresearch.unl.pt/en/publications/536b5e84-a9bc-4105-ba0f-9ef2105fc200.
    DOI: 10.1016/j.toxlet.2014.06.803
  9. Monitoring of the lactonase activity of paraoxonase-1 enzyme in HIV-1-infection. 2014. Pereira SA; E.C. Monteiro; Umbelina de Jesus Albino Caixas; Judit Morello; Aline Teixeira Marinho; Clara Lúcia Gonçalves Dias. https://novaresearch.unl.pt/en/publications/634c6fad-d170-44e8-ab69-74796eb409af.
  10. An animal model to explore efavirenz toxicokinetics and its relation to neurological phenotype. 2014. Pereira SA; E.C. Monteiro. https://novaresearch.unl.pt/en/publications/b5db4ae5-daf5-4c5a-b91c-83007777b01d.
    10.1016/j.toxlet.2014.06.813
  11. Thiol status in HIV-infected patients: The effect of nevirapine metabolism. 2014. Inês Varanda de Jesus Faustino; Aline Teixeira Marinho; Clara Lúcia Gonçalves Dias; Umbelina de Jesus Albino Caixas; Pereira SA; E.C. Monteiro. https://novaresearch.unl.pt/en/publications/834768f1-7bc8-4598-87b5-55c902c26d71.
  12. Sex differences in apolipoprotein A1 and nevirapine-induced toxicity. 2014. Pereira SA; E.C. Monteiro; Clara Lúcia Gonçalves Dias; Aline Teixeira Marinho. https://novaresearch.unl.pt/en/publications/1919760a-1152-4c90-ac77-6fd3853bc7b4.
    10.7448/IAS.17.4.19575
  13. PON-1 activity as a protective player in nevirapine hepatotoxicity: Data comparison in 2D and 3D cell cultures. 2014. Aline Teixeira Marinho; Clara Lúcia Gonçalves Dias; Pereira SA; E.C. Monteiro. https://novaresearch.unl.pt/en/publications/fa585f80-cf47-47f4-a21b-6ecdebdb704a.
  14. 3D hepatocyte cultures: A useful tool in the study of Nevirapine bioactivation and toxicity. 2013. Pereira SA. https://novaresearch.unl.pt/en/publications/3f026dba-afe2-4f84-b45b-b5d77ffd642b.
  15. Mass spectrometric detection of hemoglobin adducts from the anti-HIV drug nevirapine and its metabolite 12-hydroxy-nevirapine in rats. Abstracts of Papers of the American Chemical Society. 2010. E.C. Monteiro; Pereira SA; Marques, Matilde; Godinho, Ana L. A.; Oliveira, Conceicao; Pereira, Sofia A.; Monteiro, Emilia C.; Beland, Frederick A.; Antunes, Alexandra M. M.. https://novaresearch.unl.pt/en/publications/6362d1d6-812d-425d-97d3-c107d81d38ae.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/03/21 Environmental Phenotypes of Kidney related diseases LS4Future Meeting
(Vimeiro, Portugal)
2023/02/03 CORE CONCEPTS IN PHARMACOKINETICS FOR THE INTEGRATED MASTER’S DEGREE IN MEDICINE: A MULTIDISCIPLINARY APPROACH 53rd Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2022/10/11 Activation of the aryl hydrocarbon receptor in the kidney. Implications & Consequences Translational Nephrology Building the bridge from the bench-to-bedside
Portuguese Society of Nephrology (Setúbal)
2022/06 Renal functinal Reserve - how to assess it? II Rim do desportista, Hospital das Forças Armadas, Lisboa Rim Desportista
Hospital das forças Armadas
2022 Pharmacometabolomics of sulfonation: Urinary metabolite profile can predict sulfonation capacity in man. 40ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia./ XXXIX Reunião de Farmacologia Clínica/ XX Reunião de Toxicologia
Porto Palácio by The Editory - The Editory Collection Hotels (Porto, Portugal)
2021/02/19 CYSTEINE OXIDATION IS A PUTATIVE AHR ACTIVATOR IN KIDNEY CORTEX (MAL)ADAPTATION TO CHRONIC INTERMITTENT HYPOXIA CONDITIONS SPF Meeting 2021
Sociedade Portuguesa de Farmacologia; Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)
2021/02/19 NOVEL MECHANISMS IN ANGIOGENESIS: OXIDATIVE STRESS AS A PROMOTER OF MONOCYTE-TO-ENDOTHELIAL CELL DIFFERENTIATION AND ENDOTHELIAL CELL ACTIVATION SPF Meeting 2021
Sociedade Portuguesa de Farmacologia; Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)
2021/02/17 IMPACT OF CHRONIC INTERMITTENT HYPOXIA ON TRYPTOPHAN METABOLISM SPF Meeting 2021
Sociedade Portuguesa de Farmacologia; Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)
2021/02/17 PHARMACOLOGICAL PATHWAYS OF THE AHR ANTAGONIST CH-223191 IN KIDNEY IN A MODEL OF ARTERIAL HYPERTENSION ASSOCIATED TO SLEEP APNEA SPF Meeting 2021
Sociedade Portuguesa de Farmacologia; Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)
2021 Why is the AhR pathway activated at kidney in a model of hypertension associated to obstructive sleep apnea? A focus on tryptophan metabolism XXXV Congresso Português de Nefrologia
Sociedade Portuguesa Nefrologia (Vilamora)
2021 A bet in olive oil: hydroxytyrosol reverts increased blood pressure and cysteine disulfides induced by chronic intermittent hypoxia ISAC XXI VIRTUAL KICKOFF MEETING
Nova Medical School
2021 Hydroxytyrosol is a potential modulator of cysteine redox dynamics and controls increased blood pressure in a model of hypertension associated to obstructive sleep apnea 3rd NMS Symposium on Chronic Diseases and Translational Science
CEDOC (Lisbon, Portugal)
2020 Effect of hydroxytyrosol in hypertension induced by chronic intermittent hypoxia L Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVIII Reunião de Farmacologia Clínica/ XIX Reunião de Toxicologia
Faculdade de Farmácia da Universidade de Coimbra (Coimbra, Portugal)
2020 The antihypertensive effect of AHR antagonist is related to circadian variation of blood pressure in Chronic Intermittent Hypoxia condition L Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVIII Reunião de Farmacologia Clínica/ XIX Reunião de Toxicologia
(Coimbra, Portugal)
2020 Kidney participation in drug metabolism – opportunities to investigate new players in hypertension 1ª Reunião do ´´Núcleo de Nefrologia de Translação´´
Sociedade Portuguesa Nefrologia (Coimbra, Portugal)
2020 Lesson within Framework of international communication and cooperation between educators/ teachers of clinical pharmacology.
Masaryk University – Fakulty of Medicine (Brno, Czech Republic)
2019/05/10 Phenotyping the mercapturate pathway to address kidney tubular function. Casual Friday with Science
Centro de estudos de doenças crónicas, Universidade Nova de Lisboa Faculdade de Ciências Médicas (Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/09/01 - Current Determinants of the activation of the AhR-Cyp1a1 axis in kidney in arterial hypertension associated to obstructive sleep apnea: a matter of agonist and intermittent hypoxia
Supervisor
 Health Sciences (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/09/01 - Current Precision Urology: Metabolic Phenotype of Patients with Metabolic Syndrome and Recurrent Nephrolithiasis
Co-supervisor
 Health Sciences - Medicine (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/09/01 - Current Emerging roles of (per)Sulfidome in Kidney Disease
Co-supervisor
 Molecular Biosciences (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/09 - 2022/03/24 Hydroxytyrosol and hypertension associated with chronic intermittent hypoxia: impact and contribution of AhR alternative pathway
Supervisor of Maria João Andrade Correia
 Biomedicine (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2022 Variability of sulfotransferase 1A1 (SULT1A1) activity in humans: an approach to improve predictive drug response.
Co-supervisor of Natália Carvalheira de Freitas Marto
 Medicine (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020 - 2021/01 Targeting AhR metabolic circuitry for better management of arterial hypertension in obstructive sleep apneia.
Supervisor of António Pimpão
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2021 Monocytes as neoangiogenesis promoters and anti-cancer targets.
Co-supervisor of Filipa Lopes Coelho
 Mechanisms of disease and Regenerative Medicine (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2020 Systemic Lupus Erythematosus: development of methodologies based on the technique of mass spectrometry for the diagnosis / prognosis of the disease.
Co-supervisor of Catarina Sofia Romão Charneira
 Chemistry (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2020 Aryl hydrocarbon receptor (AhR): a therapeutic target for systemic hypertension associated with chronic intermittent hypoxia.
Co-supervisor of Nuno Filipe Ramos Coelho
 Mecanismos de Doença e Medicina Regenerativa (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2019 Investigating the role of the mercapturate pathway in kidney function for the identification of an early indicator tubular dysfunction.
Supervisor of Clara Lúcia Gonçalves Dias
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2019 Cysteine, a facilitator of hypoxia adaptation and a promoter of drug resistance- a new route to better diagnose and treat ovarian cancer patients.
Co-supervisor of Ana Sofia de Almeida da Costa Nunes
 Mecanismos de Doença e Medicina Regenerativa (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2018 Teaching an old drug new tricks: reprofiling of nevirapine as an HDL modulator. Individual PhD Fellowship SFRH/BD/92191/2013
Supervisor of Aline Teixeira Marinho
 Mechanisms of Disease and Regenerative Medicine (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016/10 - 2017 Changes in N-acetyltransferase 8 in kidney tubular cell: Injury, recovery and mesenchymal stem/stromal cell treatment.
Supervisor of Patrícia Canotilho dos Santos Grácio
 Ciências de Engenharia - Engenharia Biomédica (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - 2017 The anti-HIV drug Efavirenz: a challenge on molecular mechanisms of drug associated neurocognitive disorders. Individual PhD Fellowship SFRH/BD/86791/2012.
Supervisor of Nádia Filipa Marques Grilo
 Ciências da Vida (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2016 S-thiolated protein profile to assess the redox modulation effects of antiretroviral drugs.
Supervisor of Maria João Correia
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015 Molecular targeting of proteins by homocysteine in clinical and familial hypercholesterolemia.
Supervisor of Ana Rita Lemos
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015 Usefulness of zebrafish model to assessglomerular and tubular alterationsinduced by tenofovir.
Co-supervisor of Rita Gorgulho
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2015 Zebrafish as a model for toxicological studies: is there a role for Paraoxonase?
Supervisor of Lara Andreia Pires Afonso
 Biologia Humana e Ambiente (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2013 Nevirapine biotransformation in a type II diabetes model.
Supervisor of Patricia Marques Rodrigues
 Biotecnologia (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2013 HDL in HIV-1 infection: a quality perspective through paraoxonase-1 activities.
Supervisor of Clara Dias
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2013 New insights on nevirapine use: A mechanistic perspective of its toxic events.
Supervisor of Aline Teixeira Marinho
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2011 - 2012 Protein adducts from the anti-HIV drug abacavir – possible biomarkers of drug toxicity.
Supervisor of Nádia Filipa Marques Grilo
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/02/07 - 2024/02/09 Organisation of the 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology (2024/02/07 - 2024/02/09)
Meeting (Member of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2015 Organization of the Meeting of the Portguese Society of Pharmacology 2015 (2015 - 2015)
Meeting (Member of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021 - Current Chair of Cardiovascular & Renal Pharmacology session
Congress
 3rd NMS Symposium on Chronic Diseases and Translational Science
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2014 - Current Pariticipation in the OPEN DAYS of the institute (outreach activities).
Other
 CEDOC Open Days
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2021/04/11 - 2021/04/14 ESH-ISH Joint Meeting - Hypertension meeting participation
Meeting
 ESH-ISH Joint Meeting
2012 - 2020 Chariwomen at several (pharmacology, cancer, toxicology) sessions at SPF meetings
Meeting
 SPF meeting
Sociedade Portuguesa de Farmacologia, Portugal
2019/09/04 - 2019/09/06 Co-author of one of the works presented: Effect of cysteinyl- S-conjugates on the function and structure of human enzymes involved in hydrogen sulfide metabolism
Meeting
 NOVABiophysica
Universidade Nova de Lisboa, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/07/20 In Vivo Phenotyping of Sult1a enzymes in man: implications for precision medicine
Supervisor
 Natália Marto (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/02/23 "Nose-to-brain Delivery of Lacosamide, Levetiracetam and Zonisamide and the Impact of BCRP Efflux: an In Vitro/In Vivo Approach".
(Thesis) Arguer
 Joana Carrapiço Gonçalves (PhD)
Universidade de Coimbra, Portugal
2021/12/20 "Targeting the carotid bodies to treat obesity"
(Thesis) Arguer
 Bernardete Sofia Freitas de Melo. (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/01/26 "Development of point-of-care tests using enzyme (NiR & PON) based electrochemical biosensors."
Thesis Member
 Tiago Carvalho Monteiro (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020/12/09 The neurotoxicity of doxorubicin and mitoxantrone: chemobrain studies using infant, adult, and old mice.
(Thesis) Arguer
 Ana Rita Constantino Dias de Carvalho (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2020/01 Evaluation to recognition of foreign qualifications at the level of Doctorate of the thesis “Regulation of Clostridium acetobutylicum glutamine synthetase glnA gene”. Ivo Pedro Fierro-Monti (PhD)
2020 Metabolomics of Menopause in HIV-infected women
(Thesis) Arguer
 Cláudia Nunes (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/11/28 Characterization and modulation of the Renin-Angiotensin System in Diabetic Retinopathy.
(Thesis) Arguer
 Brigite Ladeira Cabrita (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/02/19 Bioanalytical tools for unraveling part of the puzzle of the biochemical phenomena in epilepsy: neuromediators and antiepileptic drugs
(Thesis) Arguer
 Beatriz Marques da Fonseca (PhD)
Universidade da Beira Interior, Portugal
2017 Estratégias in vitro e in vivo para o estudo da bioativação do fármaco anti-HIV Etravirina
(Thesis) Arguer
 Ana Godinho (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 Development of three-dimensional umbilical cord-derived cell culture for differentiation into hepatocyte-like cells: a potential breakthrough in toxicological drug screening
(Thesis) Arguer
 Madalena Cipriano (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 Bioactivação do fármaco anti-VIH Nevirapina: quantificação por espectrometria de massa de alta resolução de adutos covalentes formados com a hemoglobina.
(Thesis) Arguer
 Catarina Oliveira (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 Evaluation of the therapeutic potential of the umbilical cord tissue-derived mesenchymal stromal cells (UCX®) 3D cultures for tissue regeneration
(Thesis) Arguer
 Sérgio Camões (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 Metabolitos fenólicos do fármaco anti-HIV Nevirapina: Mecanismos de bioactivação em culturas 3D de hepatócitos de rato
(Thesis) Arguer
 Pedro Pinheiro (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Association member

Society Organization name Role
2022 - Current COST Action CA20121 Bench to Bedside transition for Pharmacological regulation of NRF2 in non communicable diseases Member
2016 - Current Portuguese Society of Nephrology
2007 - Current Portuguese Society of Pharmacology
2020 - 2024 CA19115 - Network for blood pressure research in children and adolescents. (https://www.cost.eu/actions/CA19115/#tabs|Name:overview) Member
2020 - 2024 CA19127 - Cognitive decline in Nephro-Neurology: European Cooperative Target. (https://www.cost.eu/actions/CA19127/#tabs|Name:overview) Member
2016 - 2020 Diagnosis, Monitoring and Prevention of exposure related non-communicable diseases, DiMoPEx (CA 15129) Member
2005 - 2011 SIDAnet Portuguese Association Secretary

Committee member

Activity description
Role 		Institution / Organization
2023/02 - Current NMS Research area Cardiovasular, renal and metabolic diseases
Coordinator
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/04/24 - Current Coordinator of the Pedagogical Committee of the 2nd year of the Integrated Master in Medicine.
Coordinator
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021 - 2021 Selection of abstracts at iMed Conference® 13.0
Advisor / Consultant
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2019 Development of guidelines and evaluation structure for the course: Thesis within the scope of the PhD in Biomedicine PhD
President / Vice-president
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2019 Member of the Scientific Committee of the Faculdade de Ciências Médicas de Lisboa
Member
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Conference scientific committee

Conference name Conference host
2015 - Current Meeting of the Portuguese Society of Pharmacology Faculdade de Ciências Médicas de Lisboa
2021/06/16 - 2021/06/18 Third CEDOC Symposium on Chronic Diseases and Translational Science CEDOC-NMS
2021/02/17 - 2021/02/17 3rd NMS Symposium on Chronic Diseases and Translational Science CEDOC|NMS
2017 - 2017 VI in4Med Faculdade de Medicina, Universidade de Coimbra

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current Teaching in Curricular Unit of Integrative Biomedicine of Biomedicine PhD 1st Year BIOMEDICINE PhD Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020 - Current Clinical pharmacology within the framework of international communication and cooperation between educators/ teachers of clinical pharmacology. Medicine (Bachelor (1st cycle)) Masarykova univerzita, Czech Republic
2018 - Current Master NOVA Biomedical Research. Curriular Unit "Aging and chronic diseases: from molecular mechanisms to therapies" NOVA Biomedical Research (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2013 - Current Integrated Master Degree in Medicine. Nuclear curricular unit "Infection: aetiology, pathogenesis and therapeutics; practical classes, elaboration and correction of tests". Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - Current Integrated Master Degree in Medicine. Nuclear curricular unit "General Pharmacology; theoretical and practical classes, elaboration and correction of tests". Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - Current Integrated Master Degree in Medicine. Nuclear curricular unit of Phatophysiology and Therapeutic Targets; theoretical and practical classes, elaboration and correction of tests. Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - Current PhD Program "Life Sciences". Lecture Translational Research. Ciências da Vida (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/06/05 - 2020/06/06 Seminar - NOVA Biomedical Research Master Seminars (Mestrado)
2016 - 2017 Integrated Master Degree in Medicine. Optional curricular unit "Methods for the quantification of endogenous metabolites in biological fluids" Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2017 Master in Clinical Trials and Medical Affairs Master em Monitorização de Ensaios Clínicos e Medical Affairs (Mestrado) Centro de Estudos Superiores da Indústria Farmacêutica, Portugal
2013 - 2015 Integrated Master Degree in Medicine. Optional curricular unit "Translational Medicine in Chronic Diseases and Aging". Topic: "Pharmacogenomics, ratios of metabolites and metabolic phenotypes". Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2013 - 2015 PhD Program "Mechanisms of Disease and Regenerative Medicine". Curricular unit "Degenerative and Chronic Diseases" . Topic: "Drug toxicity as mechanism of disease. The roleof antiretroviral drug toxicity: from cell to clinic". Mecanismos de Doença e Medicina Regenerativa (Doutoramento) Universidade do Algarve, Portugal

Universidade Nova de Lisboa, Portugal
2012 - 2013 Integrated Master Degree in Medicine. Topics: "Pharmacokinetics", Drug toxicity", "Drugs inhibiting Cellular Proliferation", "Variability in Drug Response" Medicina (Mestrado integrado) Universidade do Algarve, Portugal
2006 - 2007 Postgraduate Course in Monitoring of Clinical Trials. Lecture in Pharmacokinetics Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022 - Current 2022 PhD grant evaluation in the area of Biomedicine
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal
2013 - Current Prize Astrazeneca Innovate Foundation at iMed Conference.
Evaluator
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/09/30 - 2021/10/02 Juri - Best poster - 12 Topics in Rheumatology meeting Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021 - 2021 PhD grant evaluation in the area of Clinical Medicine and Health Sciences.
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal
2020/03 - 2020/04 ´´RESEARCH 4 COVID-19``: Evaluation of R&D projects and initiatives that respond to the needs of the National Health Service (SNS) in response to this and future pandemics in a very short time horizon.
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2020/03/06 - 2020/03/07 Juri - Best poster - 12 Topics in Rheumatology meeting Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2015 Pfizer Prizes for biomedical research projects in Portugal
Evaluator
 Universidade Nova de Lisboa Faculdade de Ciências Médicas
2012 - 2012 Evaluation Panel of PhD programme in Life Sciences
Evaluator
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2019/11/15 Environmental changes: Pollution as an atherogenic factor Journal NewsFarma CONGRESSO (XXVII Congresso Português de Aterosclerose)

Journal scientific committee

Journal title (ISSN) Publisher
2021/10/31 - Current MPDI - Special Issue "Small Molecules: A Field of Opportunities for Differential Diagnosis and Precision Medicine" (1420-3049)
2021/09/30 - Current Frontiers in Pharmacology - Non-Cytochrome P450 Enzymes and Extra-Hepatic Drug Metabolism: Challenges and Opportunities (1663-9812 ) Frontiers
2020/02/20 - 2020/02/20 Frontiers - Metabolomics in Toxicology: From Mechanistic Elucidation to Preventive and Therapeutic Strategies Frontiers
2019/03/31 - 2019/03/31 High-throughput - Special Issue "Adductomics: Elucidating the Environmental Causes of Disease" (2571-5135) MDPI

Mentoring / Tutoring

Topic Student name
2020 - Current Portugal Clinical Scholars Research Training (PTCSRT) Clara Matos

Other jury / evaluation

Activity description Institution / Organization
2022 - 2023 Jury for the application procedure for the PhD in Biomedicine Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - 2020/07/02 Evaluation of the Student Rita Coelho at PROJECT IN CELL AND MOLECULAR BIOLOGY discipline Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - 2020/07/02 Evaluation of the student Joana Reis at PROJECT IN CELL AND MOLECULAR BIOLOGY discipline Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/07/09 - 2020 Analysis, evaluation and selection of doctoral applications in biomedicine -5th edition (Academic year of 2019/2020). Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/07 - 2019/07 Jury on evaluation of master thesis plan of 2 students on NBR master course. Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/05/24 - 2019/05/24 International selection procedure for hiring a Doctorate under Articles 18 and 20 of Decree-Law No. 57/2016, of 29 August, amended by Law No. 57/2017. (Aviso n.º 9148/2019) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - 2019 Evaluation of doctoral intention in medicine of the project´´The effect of preoperative dexamethasone on postimplantation syndrome after endovascular aneurysm repair - protocol for a randomized controlled trial´´ from the student Ana Rita Pinho Soares Ferreira. Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2016 Jury of the public tender to contrat a Superior Technician at Faculdade de Ciências Médicas de Lisboa. Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2014 Evaluation of the experimental period of the Superior Technician Inês Varanda de Jesus Faustino Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2011 - 2011 Jury of the public tender to contrat a Superior Technician at Faculdade de Ciências Médicas de Lisboa. Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Distinctions

Award

2022 Best work submitted in Basic Nephrology
2022 DeCastro-Heymans-Neil Award" Best Oral Presentation 3rd Prize (for best oral presentation) Renal AHR-CYP1A1 activation by chronic intermittent hypoxia is related to arterial hypertension and depends on its chronicity.
2022 Bolsa de Investigação em Urologia 2022
Sociedade Portuguesa de Neurologia, Portugal
2021 Best work submitted in Basic Nephrology
Sociedade Portuguesa de Nefrologia, Portugal
2017 Best work submitted in Basic Nephrology
Sociedade Portuguesa de Nefrologia, Portugal
2017 Travel Grant. Thiol oxidation in toxicity and signaling workshop organized by EMBO
2015 Gilead GÉNESE Portugal Program. PGG/032/2015 – Renal tubular lesion in HIV-infected patients: progression and interaction. (PGG/032/2015).
Gilead Sciences Lda, Portugal
2013 Project: HIV-Nefromics - Novel markers of antiretroviral induced nephrotoxicity in HIV infected patients
Sociedade Portuguesa de Nefrologia, Portugal
2013 Best Oral Presentation on the "2nd International Conference on Occupational & Environmental Toxicology", Journals of Toxicology and Environmental Health and Taylor & Francis Group
2013 Honoroble mention for best poster on the "5.0 iMed Conference"
2011 ERASMUS Movility Grant for training at the Pharmacy & Pharmacology Department of Slotervaart Hospital, Amsterdam, Holland
2009 Research Fellowship Luso-American Development Foundation (FLAD)
2004 Best oral presentation - clinical case. VI Jornadas de Infecção pelo VIH
Sociedade Portuguesa de Medicina Interna, Portugal
2002 BIC fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2001 Program of stays in superior education (Prodept). PRODEP III MEDIDA 3 ACÇÃO, public call n1/3.2/PRODEP/2002
2001 PRODEPT fellowship

Other distinction

2018 Prémio melhor comunicação em painel Clara G. Dias, Nuno R. Coelho, Maria J. Correia, Filipa Lopes-Coelho, Maria J. Meneses, Inês Sousa-Lima, Jacinta Serpa, Maria P. Macedo, Karina Soto, Emília C. Monteiro, Sofia A. Pereira. Renal cysteine-disulfide stress