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Cardoso-Cruz H obtained his BSc in Applied Biology at the University of Minho (Braga, Portugal, 2002). After, he moved to Oporto to join the Prof. Vasco Galhardo lab to pursue his post-graduate studies in neurosciences. In 2008, he obtained his MSc degree in Bioinformatics at the Oporto Sciences Faculty under supervision of Prof. A. Rocha (Applied Mathematics) and co-supervision of Prof. V. Galhardo (Oporto Medicine Faculty (FMUP), Experimental Biology department). In 2008, he was awarded with a FCT fellowship to carry out his doctoral studies under supervision of Prof. Vasco Galhardo. In 2012, he obtained his PhD degree in Neuroscience at the FMUP. In 2013, he was awarded with a FCT fellowship to carry out his postdoctoral studies at the IBMC/ Morphophysiology of the Somatosensory System Group. Recently, Cardoso-Cruz is a PhD CEEC_ind assistant researcher at the i3S/Pain Neurobiology group. His research interest is the relationship between pain and cognitive functions. His research involves an interdisciplinary approach, combining in-vivo electrophysiology techniques, behavior evaluation, optogenetic brain stimulation, development of analytical tools for the study of neuronal dynamics, and design and implementation of algorithms for decoding neuronal data.
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Identification

Personal identification

Full name
Helder Rui Cardoso da Cruz

Citation names

  • Cardoso-Cruz, Helder
  • Cruz, H. R.
  • Cardoso-Cruz, H.

Author identifiers

Ciência ID
6B15-A32E-33A9
ORCID iD
0000-0001-5191-3828
AuthenticusID
R-000-KFH
Google Scholar ID
https://scholar.google.pt/citations?hl=pt-PT&user=s9eeQDMAAAAJ
Researcher Id
N-3486-2019

Email addresses

  • hcruz@med.up.pt (Professional)
  • hcruz@ibmc.up.pt (Professional)

Telephones

Telephone
  • 226074900 (Professional)

Addresses

  • i3S - Instituto de Investigação e Inovação em Saúde / IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)
  • Faculdade de Medicina, Departamento de Biomedicina - Piso 4, Rua doutor Plácido da Costa, 4200-450, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
French Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2)
Education
Degree Classification
2020/01/08 - 2020/01/31
Concluded
 Building and Leading Research Teams (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Psicologia e de Ciências da Educação, Portugal
Approved
2019/09/09 - 2019/09/20
Concluded
 Course in Laboratory Animal Science Advanced Training - FELASA Category C (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Approved
2015/02 - 2015/03
Concluded
 Theoretical Component of Introductory Course in Laboratory Animal Science - FELASA Category B (Outros)
Major in Laboratory Animal Science
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
 Approved
2008/02/01 - 2012/09/14
Concluded
 Neurociências (Doutoramento)
Major in Ramo Neurociências Experimentais
Universidade do Porto Faculdade de Medicina, Portugal
"Cortical and subcortical oscillatory dynamics in nociceptive information processing: sensorial and cognitive aspects" (THESIS/DISSERTATION)
 Approved
2005/09/01 - 2008/01/23
Concluded
 Bioinformática (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"The thalamocortical oscillations: algorithms to search neuronal patterns." (THESIS/DISSERTATION)
 Very Good
1997/09/01 - 2002/12/01
Concluded
 Biologia Aplicada (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"The use of animal cell lines for biocompatibility studies of starch-based polymeric biomaterials." (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2023/07/16 - Current Auxiliary Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/01/01 - 2023/07/15 Researcher (Research) Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto, Portugal
2014/10/01 - 2018/12/31 Postdoc (Research) Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
2013/12/01 - 2014/09/30 Postdoc (Research) Universidade do Porto - Faculdade de Medicina, Portugal
Universidade do Porto - Faculdade de Medicina, Portugal
2013/03/01 - 2013/10/31 Postdoc (Research) Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
2012/02/16 - 2013/02/28 Researcher (Research) Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
2005/08/01 - 2008/01/31 Researcher (Research) Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
2002/05/01 - 2005/07/31 Researcher (Research) Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
2001/02/01 - 2001/10/01 Research Trainee (Research) Universidade do Minho - Departamento de Biologia, Portugal
Universidade do Minho, Portugal

Others

Category
Host institution 		Employer
2008/02/01 - 2012/01/31 FMUP International Neurosciences Doctoral Program - PhD Student; FCT Grant SFRH/BD/42500/2007; Supervisor Prof. V. Galhardo (FMUP) Universidade do Porto - Faculdade de Medicina, Portugal
Universidade do Porto - Faculdade de Medicina, Portugal
2005/09/01 - 2008/01/28 FCUP Bioinformatics Master Program - MSc Student; Supervisors Prof. Ana P. Rocha (FCUP) and Prof. V. Galhardo (FMUP) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
(...)
Projects

Grant

Designation Funders
2024/07/01 - 2028/06/30 Orbitostriatal encoding of reward delayed gratification and impulsivity in chronic pain
PRT/BD/154966/2023
Supervisor
Universidade do Porto - Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Université Paris-Saclay, France
Fundação para a Ciência e a Tecnologia, IP
Ongoing
2014/10/01 - 2018/12/31 SHEDDING LIGHT ON PAIN-RELATED SPATIAL WORKING-MEMORY DEFICITS: An integrated approach based on prefrontal cortex networks modulation using optogenetics, pharmacological and electrophysiological correlates (Salary Grant, 108 k€)
SFRH/BPD/92203/2013
Post-doc Fellow
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
 Portuguese Foundation for Science and Technology, IP
Concluded
2013/12/01 - 2014/09/30 Modulation of fronto-hippocampal circuit oscillations: neurophysiological and behavioral correlates
info:eu-repo/grantAgreement/FCT/COMPETE/126659/PT
Post-doc Fellow
Universidade do Porto - Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/03/01 - 2013/11/30 Neural correlates of value in the corticostriatal reward-aversion circuitry
PTDC/SAU-NEU/100773/2008
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/100773/PT
Post-doc Fellow
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia, IP
Concluded
2008/02/01 - 2012/01/31 Cortical and subcortical oscillations in nociceptive information processing: cognitive and sensorial aspects (Salary Grant, 53 k€)
SFRH/BD/42500/2007
PhD Student Fellow
Universidade do Porto - Faculdade de Medicina, Portugal
 Portuguese Foundation for Science and Technology, IP
Concluded
2005/09/01 - 2008/01/31 Central pain syndromes: The role of thalamocortical spontaneous oscillations in somatosensory enhancement
POCI/SAU-NEU/55811/2004
Research Fellow
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia, IP
Concluded

Contract

Designation Funders
2023/07/16 - 2029/07/15 Shed light on comorbid pain-related Lateral Habenula network dysfunctions during cognitive motifs (Salary Grant, 365 k€)
2022.00128.CEECIND/CP1735/CT0019
10.54499/2022.00128.CEECIND/CP1735/CT0019
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/15 - 2026/01/14 PAIN ADDICT - Dopaminergic circuits underlying habit formation and addiction in animal models of chronic pain (Project Grant, 249 k€)
2022.05193.PTDC
10.54499/2022.05193.PTDC
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Institute for Research and Innovation in Health
LA/P/0070/2020
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2023/05/14 Optogenetic dissection of the prefrontal cortex networks to reverse pain-related cognitive dysfunctions (Salary Grant, 177 k€)
DL 57/2016/CP1355/CT0015
10.54499/DL57/2016/CP1355/CT0015
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/15 - 2022/01/31 MEMORYSTIM - Optogenetic modulation of prefrontal GABAergic and dopaminergic signaling to reverse pain-related cognitive deficits (Project Grant, 229 k€)
POCI-01-0145-FEDER-028181/2017, PTDC/MED-NEU/28181/2017
PTDC/MED-NEU/28181/2017
POCI-01-0145-FEDER-028181
Principal investigator
Universidade do Porto - Faculdade de Medicina, Portugal

Universidade do Porto, Portugal
Operational Competitiveness (POCI) Program - COMPETE2020, PORTUGAL2020, and National Funds through Fundação para a Ciência e Tecnologia – FCT

Fundação para a Ciência e a Tecnologia
Concluded
2018/07/15 - 2021/12/31 OPTORISK - Reward signals codification in neural populations of dopaminergic circuitry: optogenetic study of the neural correlates of decision and expectance (Project Grant, 238 k€)
POCI-01-0145-FEDER-28498/2017, PTDC/MED-NEU/28498/2017
Researcher
Universidade do Porto - Faculdade de Medicina, Portugal
 Operational Competitiveness (POCI) Program - COMPETE2020, PORTUGAL2020, and National Funds through Fundação para a Ciência e Tecnologia – FCT (Lisbon, Portugal)
Concluded
2018/07/15 - 2021/12/31 Codificação de sinais de recompensa em populações neuronais do circuito dopaminérgico: estudo optogenético dos correlatos neuronais de decisão e expectativa
PTDC/MED-NEU/28498/2017
Researcher
Universidade do Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Instituto de Investigação e Inovação em Saúde
UID/BIM/04293/2019
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2018/10/31 Porto Neurosciences and Neurologic Disease Research Initiative at i3S
Norte-01-0145-FEDER-000008
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Norte Regional Operational Programme - NORTE2020
Concluded
2013/05/01 - 2015/12/31 Molecular mechanisms of chronic pain: an integrated approach based on genetically manipulated animal models (Project Grant, 496 k€)
RECI/NEU-NMC/0138/2012
Researcher
Fundação para a Ciência e a Tecnologia, IP.
Concluded
2013/07 - 2015/06 MODULATION OF FRONTO-HIPPOCAMPAL CIRCUIT OSCILLATIONS: NEUROPHYSIOLOGICAL AND BEHAVIORAL CORRELATES (Project Grant, 188 k€)
PTDC/NEU-SCC/1516/2012
 Fundação para a Ciência e a Tecnologia, IP.
2011/01/01 - 2012/12/31 Strategic Project - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01 - 2012/12 The Pain Experience: Functional changes induced by chronic pain in the neuronal reward and aversion circuits (Project Grant, 50 k€)
126/08
Researcher
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
 Fundação Bial
Concluded
2005/01/01 - 2008/11/30 Pain Awareness: Changes induced by chronic pain in neurobiological learning and attention mechanisms (Project Grant, 40 k€)
84/04
Researcher
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
 Fundação Bial
Concluded
2002/05/01 - 2005/07/31 FUNCTIONAL DYNAMICS OF PAIN: sensorial reorganization of neuronal populations induced by chronic pain and microstimulation (Project Grant, 76 k€)
info:eu-repo/grantAgreement/FCT/POCI/38995/PT
Research Fellow
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia, IP
Concluded
2002/05/01 - 2005/04/30 ROSANA - Representation Of Stimuli as Neural Activity (Project Grant, 1.515 k€)
IST-2001-34892
Researcher
Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
 European Union
Concluded
2002/01/01 - 2002/04/30 Biocompatibility of new corn starch-based hydrogels for bone cements and in controlled drug delivery systems development (Project Grant, 100 k€)
POCTI/FCB/39196/2001
Researcher
Universidade do Minho Instituto de Polímeros e Compósitos, Portugal
 Portuguese Foundation for Science and Technology, IP
Concluded
Outputs

Publications

Book chapter
  1. Cardoso-Cruz, Helder; Monteiro, Clara; Galhardo, Vasco. Corresponding author: Cardoso-Cruz, Helder. "Corticostriatal connectivity and its application to study neuropathic pain-related impairments of cognitive processes". In Translational Research Methods for Neuropathic Pain, edited by Isaura Tavares; Hugo Leite-Almeida. Neuromethods Series of Springer Nature, 2025.
    In press
Conference abstract
  1. Cerqueira-Nunes, Mariana; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. "Orbitofrontal cortex encoding of delayed gratification and impulsivity in neuropathic pain". Paper presented in 14th Congress of the European Pain Federation EFIC, Lyon, 2025.
    Accepted
  2. Cardoso-Cruz, Helder; Galhardo, Vasco. "Reduced connectivity between prefrontal cortex and mediodorsal thalamus is associated with spatial working memory impairment in rats with inflammatory pain". Paper presented in 8th Congress of the European Federation of IASP Chapters (EFIC). October 9-12, Florence, ITALY., Florence, 2013.
    Published
  3. Galhardo, V.; Cardoso-Cruz, H.; Lima, D.. "S113 IMPAIRED WORKING MEMORY PERFORMANCE IN NEUROPATHIC RATS IS ACCOMPANIED BY REDUCED FLOW OF INFORMATION IN THE FRONTOHIPPOCAMPAL PATHWAY". 2011.
    Published • 10.1016/s1754-3207(11)70688-5
  4. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Neuropathic pain reduces connectivity between hippocampus and prefrontal cortex in rats performing a spatial working memory task". Paper presented in 8th IBRO World Congress of Neuroscience. July 14-18, Florence, ITALY, Florence, 2011.
    Published
  5. Silva, Aura; Cardoso-Cruz, Helder; Galhardo, Vasco; Antunes, Luís. "Application of Tzallis Entropy To Quantify Burst Suppression during Isoflurane Anesthesia in Rats". Paper presented in From Proceedings of the 2010 Annual Meeting of the American Society Anesthesiologists. October 16-20, San Diego, CA, USA, San Diego, 2010.
    Published
  6. Cardoso-Cruz, Helder; Galhardo, Vasco; Lima, Deolinda. "Thalamocortical information flow oscillations of circadian states during a peripheral sciatic nerve lesion". Paper presented in 13th World Congress on Pain - IASP, August 29 – September 2, 2010; Montréal, Québec, CANADA, Montréal, 2010.
    Published
  7. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Dynamic of circadian thalamocortical information flow during a peripheral neuropathic pain condition". Paper presented in 7th FENS Forum of European Neuroscience, Amsterdam, July 3-7. HOLLAND, Amsterdam, 2010.
    Published
  8. Cardoso-Cruz, Helder; Silva, Aura; Antunes, Luís; Galhardo, Vasco. "Dynamic of information flow in thalamocortical loop during different phases of isoflurane anesthesia in rats". Paper presented in 6TH CONGRESS EURONEURO, Alfândega Congress Center, 4-6th February 2010, Porto, 2010.
    Published
  9. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Properties of rat hippocampal CA1 complex-spike place cells during peripheral nerve injury". Paper presented in 6th Congress of the European Federation of IASP Chapters (EFIC) - Pain in Europe VI. September 9-12 (2009), Lisboa, 2009.
    Published
  10. Cardoso-Cruz, H.; Lima, D.; Galhardo, V.. "369 PROPERTIES OF RAT HIPPOCAMPAL CA1 COMPLEX-SPIKE PLACE CELLS DURING PERIPHERAL NERVE INJURY". 2009.
    10.1016/s1090-3801(09)60372-4
  11. Silva, Aura; Cardoso-Cruz, Helder; Silva, Francisco; Galhardo, Vasco; Antunes, Luís. "Permutation entropy and approximate entropy as measures of isoflurane anaesthesia: A study using local field potentials recordings in the rat thalamocortical axis". Paper presented in Euroanaesthesia 2009, 6-7 June, Milan, 2009.
    Published
  12. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Stability of Hippocampal Place Cells Activity After Peripheral Nerve Injury: A Study Based on Chronic Extracellular Multichannel Recordings". Paper presented in 11th Meeting of the Portuguese Society for Neuroscience. June 4-6, Braga, PORTUGAL, Braga, 2009.
    Published
  13. Galhardo, Vasco; Cardoso-Cruz, Helder; Lima, Deolinda. "Changes in the sleep-waking architecture following chronic peripheral nerve injury: a study using long-term thalamocortical local field potentials recordings". Paper presented in 12th World Congress on Pain, August 17-22, 2008, Glasgow, 2008.
    Published
  14. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Thalamocortical global dynamics of behavioral transitions during peripheral nerve injury: a study using long-term local field potentials recordings". Paper presented in 6th FENS, Forum of European Neuroscience, July 12-16, 2008, Geneve, 2008.
    Published
  15. Cardoso-Cruz, H.; Lima, D.; Galhardo, V.. "199 THALAMOCORTICAL PAIN PROCESSING IN FREELY BEHAVING RATS: A STUDY BASED ON CHRONIC EXTRACELLULAR MULTICHANNEL RECORDINGS". 2006.
    Published • 10.1016/s1090-3801(06)60202-4
  16. Cardoso-Cruz, Helder; Monteiro, Clara; Lima, Deolinda; Galhardo, Vasco. "Dynamics of corticothalamic pain processing in freely behaving rats: a multi-electrode study". 2005.
    Published
Conference poster
  1. Cerqueira-Nunes, M.; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. Corresponding author: Cerqueira-Nunes, M.. "The role of orbitostriatal circuitry in delayed gratification and chronic pain-related impulsivity". Paper presented in 7th PhDay: From theory to application - Research in Action!, 2024.
  2. Cerqueira-Nunes, Mariana; Alemi, Mobina; Pereira, Ana Raquel; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. Corresponding author: Cerqueira-Nunes, Mariana. "Optogenetic silencing of habenula-to-ventral tegmental circuit reverses pain-related spatial memory deficits". Paper presented in Encontro Ciência 2024, Alfândega do Porto, 3-5 July, Porto, PORTUGAL., 2024.
  3. Gonçalo, Araújo; Cerqueira-Nunes, Mariana; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. Corresponding author: Gonçalo, Araújo. "Dopaminergic orbitofrontal cortex modulation of spatiotemporal gratification and impulsivity in rats with inflammatory pain". Paper presented in 17º Encontro Investigação Jovem da Universidade do Porto (IJUP), 8-10 Maio, Faculdade de Economia da Universidade do Porto., 2024.
  4. Cerqueira-Nunes, Mariana; Alemi, Mobina; Amaral-Pereira, Ana; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. Corresponding author: Cerqueira-Nunes, Mariana. "Optogenetic inhibition of habenula-ventral tegmental microcircuit reverses pain-related working memory deficits.". Paper presented in Champalimaud Research Neuro Symposium, 24-27 October 2023, Lisbon, Portugal, 2023.
  5. Cerqueira-Nunes, Mariana; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. Corresponding author: Cerqueira-Nunes, Mariana. "Effects of nucleus accumbens shell lesion on neuropathic pain-related working memory deficits and pain perception". Paper presented in Second International Meeting of Portuguese Spinal Cord Injury Researchers. 13 June, Porto, Portugal., 2022.
  6. Nunes, Mariana; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. Corresponding author: Nunes, Mariana. "Effects of nucleus accumbens shell lesions on neuropathic pain-related working memory deficits and pain perception". Paper presented in 2nd International Meeting of Portuguese Spinal Cord Injury Researchers, 2022.
  7. Cerqueira-Nunes, Maiana; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. Corresponding author: Cardoso-Cruz, Helder. "Infralimbic-Nucleus accumbens microcircuit underlies neuropathic pain-related working memory deficits". Paper presented in IJUP - Investigação Jovem na Universidade do Porto, 4-6 May 2022. Porto, PORTUGAL., 2022.
  8. Rodrigues, Diogo R.; Cardoso-Cruz, Helder; Galhardo, Vasco; Monteiro, Clara. "Epigenetics in the Brain: A Study in a Rat Model of Neuropathic Pain". Paper presented in 14º Encontro Investigação Jovem da Universidade do Porto, Porto, Portugal, 2021.
  9. Faria, Joana; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. "The role of corticostriatal circuitry in pain responses and pain-related working memory deficits". Paper presented in 13º Encontro de Investigação Jovem da Universidade do Porto, 13-15 Fevereiro 2020, Reitoria, Porto, PORTUGAL, 2020.
  10. Pereira, Ana Raquel; Alemi, Mobina; Paiva, Pedro; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. "Optogenetic neuromodulation of prefrontal-hippocampal theta connectivity reverses pain-related working-memory deficits". Paper presented in i3S Annual Meeting, 28-29 November 2019, Póvoa do Varzim, Portugal, 2019.
  11. Faria, Joana; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. "Optogenetic activation of corticostriatal circuitry revealed an important antinociceptive effect, but no significant impact in pain-related working memory deficits". Paper presented in i3S Annual Meeting, 28-29 November 2019, Póvoa do Varzim, Portugal, 2019.
  12. Faria, Joana; Paiva, Pedro; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. "Abnormal prefrontal-hippocampal connectivity supports pain-related working memory deficits". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 30 May - 1 June, Lisbon, PORTUGAL., 2019.
  13. Faria, Joana; Paiva, Pedro; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. "Abnormal prefrontal-hippocampal connectivity supports pain-related working memory deficits". Paper presented in 7th i3S Annual Meeting, 29-30 November, Póvoa do Varzim, PORTUGAL., 2018.
  14. Laranjeira, Inês; Paiva, Pedro; Monteiro, Clara; Cardoso-Cruz, Helder; Galhardo, Vasco. "Selective optogenetic inhibition of prelimbic excitatory neurons during delay-period reverses pain-related working memory deficits". Paper presented in XV Meeting of Portuguese Society for Neuroscience. May 25-26, Braga, PORTUGAL., 2017.
  15. Laranjeira, Inês; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. "Optogenetic modulation of the corticostriatal circuitry in chronic pain". Paper presented in IJUP - Investigação Jovem na Universidade do Porto, 8-10 February. Porto, PORTUGAL., 2017.
  16. Galhardo, Vasco; Cardoso-Cruz, Helder; Monteiro, Clara; Dourado, Margarida. "Orbitofrontal encoding of risk preference in a rodent gambling task of decision-making is modulated by dopamine D2/D3 receptors". Paper presented in 9th Congress of the European Federation of IASP Chapters (EFIC), Vienna, Austria, 2-5 September 2015., 2015.
  17. Monteiro, Clara; Cardoso-Cruz, Helder; Dourado, Margarida; Galhardo, Vasco. "Altered expression of dopamine receptors in hippocampus paralels the reduction in hippocampus functional connectivity in neuropathic rats". Paper presented in 9th Congress of the European Federation of IASP Chapters (EFIC), Vienna, Austria, 2-5 September 2015., 2015.
  18. Monteiro, Clara; Cardoso-Cruz, Helder; Dourado, Margarida; Lima, Deolinda; Galhardo, Vasco. "Decreased anxiety and enhanced fronto-hippocampal connectivity in the Prrxl1 knockout mouse model of congenital hypoalgesia". Paper presented in IBNS International Behavioral Neuroscience Society 24th Annual Meeting, Victoria, British Columbia, Canada, 2-7 June 2015, 2015.
  19. Paiva, Pedro; Cardoso-Cruz, Helder; Dourado, Margarida; Galhardo, Vasco. "Optogenetic inhibition of mPFC pyramidal population improves working memory performance in a delayed non-matching to sample task". Paper presented in XIV Meeting of the Portuguese Society for Neurosciences, 4-5 of June 2015, Póvoa do Varzim, PORTUGAL., 2015.
  20. Galhardo, Vasco; Cardoso-Cruz, Helder; Monteiro, Clara; Dourado, Margarida. "Systemic modulation of dopamine D2/D3 receptors revert orbitofrontal neurophysiological neural correlates of risk preference in a rodent gambling task of decision-making under uncertainty". Paper presented in IBNS International Behavioral Neuroscience Society 24th Annual Meeting, Victoria, British Columbia, Canada, 2-7 June 2015., 2015.
  21. Dourado, Margarida; Cardoso-Cruz, Helder; Paiva, Pedro; Monteiro, Clara; Galhardo, Vasco. "Activation of dopaminergic D2/D3 receptors reverses hippocampus-related working memory deficit induced by neuropathic pain". Paper presented in 4th Encontro de Doutorandos da Faculdade de Medicina da Universidade do Porto, 9 December 2014, Porto, PORTUGAL., 2014.
  22. Dourado, Margarida; Cardoso-Cruz, Helder; Paiva, Pedro; Monteiro, Clara; Galhardo, Vasco. "Activation of dopaminergic D2/D3 receptors reverses hippocampus-related working memory deficit induced by neuropathic pain". Paper presented in 4th I3S Annual Meeting, 30-31 of October 2014, Póvoa do Varzim, PORTUGAL., 2014.
  23. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Neuropathic pain condition reduces hippocampus-prefrontal cortex connectivity in rats performing a spatial working memory task". Paper presented in 8th Congress of the European Federation of IASP Chapters (EFIC). October 9-12, Florence, ITALY, 2013.
  24. Cardoso-Cruz, Helder; Dourado, Margarida; Lima, Deolinda; Galhardo, Vasco. "Reduced hippocampus-prefrontal córtex connectivity in rats performing a spatial working memory task under neuropathic pain condition". Paper presented in XIII Reunião da Sociedade Portuguesa de Neurociências. 30,31 de Maio e 1 Junho, Luso, PORTUGAL, 2013.
  25. Cardoso-Cruz, Helder; Dourado, Margarida; Raimundo, Mariana; Monteiro, Clara; Lima, Deolinda; Galhardo, Vasco. "Uncovering connectivity interactions between medial prefrontal cortex and mediodorsal thalamus in rats performing a spatial working memory task under an inflammatory pain condition". Paper presented in I3S - Scientific Retreat 2012, May 11-12, Póvoa de Varzim, PORTUGAL., 2012.
  26. Galhardo, Vasco; Cardoso-Cruz, Helder; Lima, Deolinda. "Impaired working memory performance in neuropathic rats is accompanied by reduced flow of information in the frontohippocampal pathway". Paper presented in 7th Congress of the European Federation of IASP Chapters (EFIC). September 21-24, Hamburg, GERMANY., 2011.
  27. Galhardo, Vasco; Cardoso-Cruz, Helder; Lima, Deolinda. "Reduced hippocampal-prefrontal cortex connectivity in rats performing a spatial working memory task under neuropathic pain condition". Paper presented in 12th Meeting of the Portuguese Society for Neurosciences (SPN), May 26-28 Lisbon, PORTUGAL., 2011.
  28. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Prefrontal cortex/hippocampal CA1-field circuit in rats performing a spatial working memory task under a neuropathic pain condition.". Paper presented in I3S - Scientific Retreat 2011. May 5-6, Póvoa de Varzim, PORTUGAL., 2011.
  29. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Dynamic of circadian thalamocortical information flow during a peripheral neuropathic condition". Paper presented in I3S Scientific Retreat 2010. 6-7 May, Póvoa do Varzim, PORTUGAL., 2010.
  30. Cardoso-Cruz, Helder; Deolinda, Lima; Galhardo, Vasco. "Properties of rat hippocampal CA1 complex-spike place cells during peripheral nerve injury". Paper presented in 6th Congress of the European Federation of IASP Chapters (EFIC) – Pain in Europe VI. September 9-12 (2009), Lisbon, PORTUGAL., 2009.
  31. Cardoso-Cruz, Helder; Deolinda, Lima; Galhardo, Vasco. "Stability of Hippocampal place cells after peripheral nerve injury: A study based on chronic extracellular multichannel recordings.". Paper presented in 11th Meeting of the Portuguese Society for Neurosciences (SPN), June 4-6, 2009 Braga, PORTUGAL., 2009.
  32. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Instability of CA1 hipocampal place cells after peripheral nerve injury". Paper presented in 2nd IBMC Scientific Retreat, April 16, 2009, Póvoa do Varzim, PORTUGAL., 2009.
  33. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Thalamocortical global dynamics of behavioral transitions in a rat model of persistent peripheral neuropathic pain". Paper presented in IBMC Scientific Retreat, 2008, 17-18 Abril, Ofir, PORTUGAL., 2008.
  34. Cardoso-Cruz, Helder; Aguiar, Paulo; Lima, Deolinda; Galhardo, Vasco. "Thalamocortical global dynamics of behavioral transitions in a rat model of persistent peripheral neuropathic pain". Paper presented in X Reunião Annual da Sociedade Portuguesa de Neurociências. 2007, 24-26 Maio, Ofir, PORTUGAL., 2007.
  35. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Thalamocortical pain processing in freely behaving rats: A study based on chronic extracellular multichannel recordings". Paper presented in Pain in Europe V - 5th Congress of the European Federation of IASP Chapters (EFIC) - 13-16 September, Istanbul, TURKEY., 2006.
  36. Galhardo, Vasco; Cardoso-Cruz, Helder; Lima, Deolinda. "Dynamics of thalamocortical oscillations in pain processing induced by peripheral formalin injection: A multielectrode study in freely behaving rats". Paper presented in FENS, Viena, AUSTRIA, 2006.
  37. Cardoso-Cruz, Helder; Mendonça, Luís; Lima, Deolinda; Galhardo, Vasco. "Microsurgical Implantation of chronic multielectrodes for neuronal recording of thalamocortical pain processing in freely behaving rats". Paper presented in 11.º Curso Prático de Microcirúrgia, Centro de Actualização Propedêutica de Formação Técnica, Campus Agrário de Vairão, Universidade do Porto, 28-30 Junho, Porto, PORTUGAL., 2006.
  38. Cardoso-Cruz, Helder; Monteiro, Clara; Lima, Deolinda; Galhardo, Vasco. "Dynamics of corticothalamic pain processing in freely behaving rats: a multi-electrode study". Paper presented in IX Reunião Anual da Sociedade Portuguesa de Neurociências, 2005, Luso, PORTUGAL., 2005.
  39. Monteiro, Clara; Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Intrathecal-Strychnine administration promotes a decrease in latency time response of hyperexcited spinal dorsal horn neurons". Paper presented in 25th European Winter Conference on Brain Research, Les Arcs, FRANCE, 2005.
  40. Lima, Deolinda; Cardoso-Cruz, Helder; Monteiro, Clara; Galhardo, Vasco. "Effect of the glycine receptor antagonist strychnine in the latency time responses of rat spinal dorsal horn neurons: a multielectrode study". Paper presented in 34th Annual Meeting of The Society for Neuroscience, San Diego, USA., 2004.
  41. Monteiro, Clara; Cardoso-Cruz, Helder; Galhardo, Vasco; Lima, Deolinda. "Intrathecal-strychnine administration promotes a decrease in latency time response of hyperexcited spinal dorsal horn neurons". Paper presented in Inaugural Symposium, International Institute for Neuroscience of Natal, March 3-7, 2004, Natal, BRAZIL., 2004.
  42. Cardoso-Cruz, Helder; Oliveira-Maia, Albino; Monteiro, Clara; Galhardo, Vasco; Lima, Deolinda. "Populational changes in rat anterior cingulate cortex neuronal network induced by pain". Paper presented in Inaugural Symposium, International Institute for Neuroscience of Natal, March 3-7, 2004, Natal, BRAZIL., 2004.
  43. Monteiro, Clara; Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Indution of bistable activity and changes in the oscillatory properties of rat spinal dorsal horn neurons following formalin injection". Paper presented in FENS, Lisboa, PORTUGAL., 2004.
  44. Cardoso-Cruz, Helder; Monteiro, Clara; Lima, Deolinda; Galhardo, Vasco. "Effect of intrathecal administration of the glycine receptor antagonist strychnine in the latency time response of neurons in the rat spinal dorsal horn". Paper presented in FENS, Lisboa, PORTUGAL., 2004.
  45. Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder; Lima, Deolinda. "Pain-induced populational activity of somatosensory neurons in the rat anterior cingulate cortex". Paper presented in 33rd Annual Meeting of The Society for Neuroscience, New Orleans, USA., 2003.
Journal article
  1. Cerqueira-Nunes, Mariana; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. Corresponding author: Cardoso-Cruz, Helder. "Inflammatory pain modifies reward preferences from larger delayed to smaller immediate rewards in male rats". Neuroscience Letters (2025): 138183. https://doi.org/10.1016/j.neulet.2025.138183.
    Open access • Published • 10.1016/j.neulet.2025.138183
  2. Dourado, Margarida; Cardoso-Cruz, Helder; Monteiro, Clara; Galhardo, Vasco. "Neuromodulation of Dopamine D2 Receptors Alters Orbitofrontal Neuronal Activity and Reduces Risk-Prone Behavior in Male Rats with Inflammatory Pain". Molecular Neurobiology (2025): https://doi.org/10.1007/s12035-025-04781-0.
    Open access • Published • 10.1007/s12035-025-04781-0
  3. Helder Cardoso-Cruz; Clara Monteiro; Vasco Galhardo. "Reorganization of lateral habenula neuronal connectivity underlies pain-related impairment in spatial memory encoding". Pain (2024): https://doi.org/10.1097/j.pain.0000000000003493.
    Open access • Published • 10.1097/j.pain.0000000000003493
  4. Cerqueira-Nunes, Mariana; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. "Orbitostriatal encoding of reward delayed gratification and impulsivity in chronic pain". Brain Research 1839 (2024): 149044. http://dx.doi.org/10.1016/j.brainres.2024.149044.
    Open access • Published • 10.1016/j.brainres.2024.149044
  5. Mariana Cerqueira-Nunes; Clara Monteiro; Vasco Galhardo; Cardoso-Cruz, Helder. Corresponding author: Cardoso-Cruz, Helder. "Deciphering the Role of the Nucleus Accumbens Shell Area on Spatial Memory Deficits Induced by Neuropathic Pain in Rats". Applied Biosciences 3 2 (2024): 283-295. https://doi.org/10.3390/applbiosci3020019.
    Open access • Published • 10.3390/applbiosci3020019
  6. Pereira, Ana Raquel; Alemi, Mobina; Cerqueira-Nunes, Mariana; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. "Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions". Neurology International 15 4 (2023): 1303-1319. http://dx.doi.org/10.3390/neurolint15040082.
    Open access • 10.3390/neurolint15040082
  7. Rodrigues, Diogo; Monteiro, Clara; Cardoso-Cruz, Helder; Galhardo, Vasco. "Altered Brain Expression of DNA Methylation and Hydroxymethylation Epigenetic Enzymes in a Rat Model of Neuropathic Pain". International Journal of Molecular Sciences 24 8 (2023): 7305. http://dx.doi.org/10.3390/ijms24087305.
    Open access • Published • 10.3390/ijms24087305
  8. Mobina Alemi; Ana Raquel Pereira; Mariana Cerqueira-Nunes; Clara Monteiro; Vasco Galhardo; Helder Cardoso-Cruz. Corresponding author: Helder Cardoso-Cruz. "Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits". Biomedicines 11 3 (2023): 820. https://doi.org/10.3390/biomedicines11030820.
    Open access • Published • 10.3390/biomedicines11030820
  9. Cardoso-Cruz, Helder; Laranjeira, Inês; Monteiro, Clara; Galhardo, Vasco. Corresponding author: Cardoso-Cruz, Helder. "Altered prefrontal-striatal theta-band oscillatory dynamics underlie working memory deficits in neuropathic pain rats". European Journal of Pain 26 7 (2022): 1546-1568. http://dx.doi.org/10.1002/ejp.1982.
    Published • 10.1002/ejp.1982
  10. Cardoso-Cruz, Helder; Paiva, Pedro; Monteiro, Clara; Galhardo, Vasco. Corresponding author: Cardoso-Cruz, Helder. "Bidirectional optogenetic modulation of prefrontal-hippocampal connectivity in pain-related working memory deficits". Scientific Reports 9 1 (2019): 10980. http://dx.doi.org/10.1038/s41598-019-47555-0.
    Open access • Published • 10.1038/s41598-019-47555-0
  11. Monteiro, Clara; Cardoso-Cruz, Helder; Galhardo, Vasco. "Animal models of congenital hypoalgesia: Untapped potential for assessing pain-related plasticity". Neuroscience Letters 702 (2019): 51-60. https://publons.com/publon/15935803/.
    Published • 10.1016/J.NEULET.2018.11.045
  12. Cardoso-Cruz, Helder; Paiva, Pedro; Monteiro, Clara; Galhardo, Vasco. Corresponding author: Cardoso-Cruz, Helder. "Selective optogenetic inhibition of medial prefrontal glutamatergic neurons reverses working memory deficits induced by neuropathic pain". PAIN 160 4 (2019): 805-823. https://publons.com/publon/15935802/.
    Published • 10.1097/J.PAIN.0000000000001457
  13. Cardoso-Cruz, Helder; Dourado, Margarida; Monteiro, Clara; Galhardo, Vasco; H. Cardoso-Cruz; M. Dourado; C. Monteiro; V. Galhardo. Corresponding author: Cardoso-Cruz, Helder. "Blockade of dopamine D2 receptors disrupts intrahippocampal connectivity and enhances pain-related working memory deficits in neuropathic pain rats". European Journal of Pain (United Kingdom) 22 5 (2018): 1002-1015. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041040353&partnerID=MN8TOARS.
    Published • 10.1002/ejp.1186
  14. Margarida Dourado; Helder Cardoso-Cruz; Clara Monteiro; Vasco Galhardo. "Effect of Motor Impairment on Analgesic Efficacy of Dopamine D2/3 Receptors in a Rat Model of Neuropathy". Journal of Experimental Neuroscience (2016): https://publons.com/publon/12939266/.
    Published • 10.4137/JEN.S36492
  15. Clara Monteiro; Helder Cardoso-Cruz; Mariana Matos; Margarida Dourado; Deolinda Lima; Vasco Galhardo; Monteiro, Clara; et al. "Increased fronto-hippocampal connectivity in the Prrxl1 knockout mouse model of congenital hypoalgesia". PAIN 157 9 (2016): 2045-2056. https://publons.com/publon/12939267/.
    Published • 10.1097/J.PAIN.0000000000000611
  16. Cardoso-Cruz, Helder; Dourado, Margarida; Monteiro, Clara; Matos, Mariana; Galhardo, Vasco. Corresponding author: Galhardo, Vasco. "Activation of dopaminergic D2/D3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury". Journal of Neuroscience 34 17 (2014): 5861-5873. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899483174&partnerID=MN8TOARS.
    Published • 10.1523/JNEUROSCI.0021-14.2014
  17. Galhardo, V.; Lima, D.; Cardoso-Cruz, H.. "Altered hippocampal-prefrontal cortex connectivity in a rat model of neuropathic pain". The Journal of Pain 14 4 (2013): S45. http://dx.doi.org/10.1016/j.jpain.2013.01.516.
    Published • 10.1016/j.jpain.2013.01.516
  18. Cardoso-Cruz, Helder; Sousa, Mafalda; Vieira, Joana B.; Lima, Deolinda; Galhardo, Vasco. "Prefrontal cortex and mediodorsal thalamus reduced connectivity is associated with spatial working memory impairment in rats with inflammatory pain". Pain 154 11 (2013): 2397-2406. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886313692&partnerID=MN8TOARS.
    Published • 10.1016/j.pain.2013.07.020
  19. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Impaired spatial memory performance in a rat model of neuropathic pain is associated with reduced hippocampus-prefrontal cortex connectivity". Journal of Neuroscience 33 6 (2013): 2465-2480. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873294842&partnerID=MN8TOARS.
    Published • 10.1523/JNEUROSCI.5197-12.2013
  20. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Neuropatia periférica induz instabilidade na codificação de informação espacial pelas place cells da área CA1 do hipocampo dorsal". DOR 20 2 (2012): 24-34.
    Published
  21. Cardoso-Cruz, Helder; Sameshima, Koichi; Lima, Deolinda; Galhardo, Vasco. "Dynamics of circadian thalamocortical flow of information during a peripheral neuropathic pain condition". Frontiers in Integrative Neuroscience 5 43 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-82255171062&partnerID=MN8TOARS.
    Open access • Published • 10.3389/fnint.2011.00043
  22. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. Corresponding author: Galhardo, Vasco. "Instability of spatial encoding by CA1 hippocampal place cells after peripheral nerve injury". European Journal of Neuroscience 33 12 (2011): 2255-2264. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955180955&partnerID=MN8TOARS.
    Published • 10.1111/j.1460-9568.2011.07721.x
  23. Silva, Aura; Cardoso-Cruz, Helder; Antunes, Luis; Galhardo, Vasco. "Dynamic of information flow in thalamocortical loop during different phases of isoflurane anesthesia in rats". European Journal of Anaesthesiology (2010): https://publons.com/publon/28738308/.
  24. Silva, Aura; Cardoso-Cruz, Helder; Silva, Francisco; Galhardo, Vasco; Antunes, Luis. Corresponding author: Antunes, Luis. "Comparison of Anesthetic Depth Indexes Based on Thalamocortical Local Field Potentials in Rats". Anesthesiology (2010): https://publons.com/publon/9381054/.
    Published • 10.1097/ALN.0B013E3181CA3196
  25. Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Stability of Hippocampal Place Cells Activity After Peripheral Nerve Injury: A Study Based on Chronic Extracellular Multichannel Recordings". Frontiers in Neuroscience 3 (2009): http://dx.doi.org/10.3389/conf.neuro.01.2009.11.058.
    Open access • 10.3389/conf.neuro.01.2009.11.058
  26. Marques, Alexandra P.; Cardoso-Cruz, Helder; Coutinho, Olga P.; Reis, Rui L.. "Effect of starch-based biomaterials on the in vitro proliferation and viability of osteoblast-like cells". Journal of Materials Science: Materials in Medicine 16 9 (2005): 833-842. http://link.springer.com/article/10.1007%2Fs10856-005-3580-7.
    Published • 10.1007/s10856-005-3580-7
  27. Cardoso-Cruz, Helder; Monteiro, Clara; Lima, Deolinda; Galhardo, Vasco. "Efeito do antagonista do receptor de Glicina (Estricnina) no tempo de latência de resposta de neurónios da medula espinal de rato: Um estudo com multieléctrodos". DOR 12 (2004): 28-35.
    Published
Thesis / Dissertation
  1. Cardoso-Cruz, Helder. "Cortical and subcortical oscillatory dynamics in nociceptive information processing: Sensorial and cognitive aspects". PhD, Universidade do Porto - Faculdade de Medicina, 2012.
  2. Cardoso-Cruz, Helder. "Thalamocortical oscillations: Algorithms to detect neural patterns". Master, Universidade do Porto Faculdade de Ciências, 2008. http://www.fc.up.pt/fcup/contactos/teses/t_050370046.pdf.
  3. Cardoso-Cruz, Helder. "The use of animal cell lines for biocompatibility studies of polymeric biomaterials based on starch-corn". Degree, Universidade do Minho - Departamento de Biologia, 2002.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2017/06/28 SHEDDING LIGHT ON PAIN-RELATED WORKING-MEMORY DEFICITS: an integrated approach to fronto-hippocampal activity modulation 2017 GABBA Doctoral Program - Neurobiology of Addiction
i3S/IBMC - Neurobiology of Addiction Group (Porto)
2016/09/14 Selective optogenetic inhibition of prelimbic excitatory neurons reverses pain-related working memory deficits FMUP-DBE Third Scientific Meeting
Third DBE Scientific Meeting (Vairão, Vila do Conde, Portugal)
2015/09/30 Spatial working-memory deficits in rodent chronic pain models FMUP - DBE Second Scientific Meeting
Second DBE Scientific Meeting (Vairão, Vila do Conde, Portugal)
2015/06/02 Systemic modulation of dopamine D2/D3 receptors revert orbitofrontal neurophysiological neural correlates of risk preference in a rodent gambling task of decision-making under uncertainty 24th Annual Meeting of the International Behavioral Neuroscience Society
International Behavioral Neuroscience Society (Victoria, Canada)
2015/06/01 Dopaminergic modulation in neuropathic pain: the role of dopamine D2/D3 receptors in pain-related spatial memory deficits Colóquio Fundação Grünenthal - Investigação em Dor em Portugal
Fundação Grünenthal (Lisbon, Portugal)
2013/05/30 Reduced hippocampus-prefrontal cortex connectivity in rats performing a spatial working memory task under neuropathic pain condition. XIII Reunião da Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências (Luso, Portugal)
2013/01/09 Conectividade fronto-hipocampal no processamento da informação nociceptiva: aspectos sensoriais e cognitivos. 2013 Seminários FMUP
Faculdade de Medicina da Universidade do Porto (Porto, Portugal)
2011/10/26 Contribution of hippocampal and cortical structures in nociceptive information processing IBMC PhD Seminar Series
Institute for Molecular and Cell Biology - PhD Seminar Series (Porto, Portugal)
2006/06/28 Microsurgical Implantation of chronic multielectrodes for neuronal recording of thalamocortical pain processing in freely behaving rats. 11.º Curso Prático de Microcirúrgia, Centro de Actualização Propedêutica de Formação Técnica, Campus Agrário de Vairão, Universidade do Porto, 28-30 Junho, Porto, PORTUGAL.
Centro de Actualização Propedêutica de Formação Técnica, Campus Agrário de Vairão, Universidade do Porto. (Vairão, Portugal)
2003/06/13 Decrease in latency time response of hyperexcited spinal dorsal horn neurons induced by intrathecal administration of strychnine VIII Reunião Anual da Sociedade Portuguesa de Neurociências.
Sociedade Portuguesa de Neurociências (Curia, Portugal)
2002/09 Effects of starch-based polymers and composites on the in vitro proliferation and viability of osteoblast-like cells 17th European Conference on the European Society for Biomaterials, Barcelone, Sept., (2002) T96, SPAIN
European Society for Biomaterials (Barcelona, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/10/25 - Current Orbitostriatal encoding of reward delayed gratification impulsivity in chronic pain
Supervisor
 Neurociências (PhD)
Universidade do Porto - Faculdade de Medicina, Portugal
2023/09/01 - 2024/11/27 Orbitofrontal cortex encoding of reward delayed gratification in chronic pain
Supervisor
 Neurobiologia (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2021/01/15 - 2022/09/28 Neuromodulation of Infralimbic-Nucleus Accumbens Shell circuit to evalute neuropathic pain-related effects on cognitive motifs
Supervisor
 Neurobiologia (Master)
Universidade do Porto - Faculdade de Medicina, Portugal
2019/06/15 - 2021/10/31 FCT project MEMORYSTIM - PTDC/MED-NEU/28181/2017 - "Optogenetic modulation of prefrontal GABAergic and dopaminergic signaling to reverse pain-related cognitive deficits" ; Function: research project post-doctoral researcher supervison.
Supervisor
 Research Project Post-doctoral researcher (Other)
Universidade do Porto - Faculdade de Medicina, Portugal
2018/12/15 - 2021/07/14 FCT project MEMORYSTIM - PTDC/MED-NEU/28181/2017 - "Optogenetic modulation of prefrontal GABAergic and dopaminergic signaling to reverse pain-related cognitive deficits" ; Function: research project master fellow researcher supervison.
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
2016/09/28 - 2017/12/05 Optogenetic modulation of the corticostriatal circuitry in chronic pain
Supervisor
 Neurobiologia (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2013/09/01 - 2014/12/16 The role of prefrontal cortex in working memory processing: local optogenetics stimulation and pharmacological modulation of dopamine D2 receptors to reverse pain-related cognitive deficits
Supervisor
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2004/08 - 2004/09 Óbidos Advanced Course in Computational Neuroscience, Edition 2004 (2004/08 - 2004/09)
Workshop (Other)
 Universidade do Porto - Faculdade de Medicina, Portugal

Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
2003/08 - 2003/09 Óbidos Advanced Course in Computational Neuroscience, Edition 2003 (2003/08 - 2003/09)
Workshop (Other)
 Universidade do Porto - Faculdade de Medicina, Portugal

Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal
2002/08 - 2002/09 Óbidos Advanced Course in Computational Neuroscience, Edition 2002 (2002/08 - 2002/09)
Workshop (Other)
 Universidade do Porto - Faculdade de Medicina, Portugal

Universidade do Porto - Instituto de Biologia Molecular e Celular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/11/27 Orbitofrontal cortex encoding of reward delayed gratification in chronic pain
Supervisor
 Gonçalo José Santos Araújo (Master)
Universidade do Porto - Faculdade de Medicina, Portugal
2023/07/11 Neural activity and pain variation in spinal cord injury patient during brain-machine interface control
(Thesis) Main arguer
 Márcia de Vasconcelos Gato (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2022/12/07 Nucleus accumbens neuronal activity in associative learning
(Thesis) Main arguer
 Catarina Vinhas Mósca Deseyve (Master)
Universidade do Minho Escola de Medicina, Portugal
2022/09/28 Neuromodulation of infralimbic-nucleus accumbens shell circuit to evalute neuropathic pain-related effects on cognitive motifs
Supervisor
 Maniana Nunes (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2017/12/05 Optogenetic modulation of the corticostriatal circuitry in chronic pain
Supervisor
 Inês Costa Laranjeira (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2014/12/16 The role of prefrontal cortex in working memory processing: local optogenetics stimulation and pharmacological modulation of dopamine D2 receptors to reverse pain-related cognitive deficits
Supervisor
 Pedro Miguel Coelho Paiva (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2025/02/06 - 2025/02/14 Biochemical and Biophysical Research Communication Elsevier
2025/01/06 - 2025/01/07 Healthcare (2227-9032) mDPI
2024/05/14 - 2024/05/16 Journal of Pain Research Dovepress
2024/04/10 - 2024/04/12 Neurology International (2035-8377) MDPI
2024/01/24 - 2024/01/26 Journal of Clinical Medicine MDPI
2023/10/25 - 2023/10/28 International Journal of Molecular Sciences MDPI
2023/10/05 - 2023/10/06 International Journal of Molecular Sciences MDPI
2023/07/21 - 2023/07/25 Molecular Pain SAGE
2023/07/14 - 2023/07/19 Biomedicines MDPI
2023/05/08 - 2023/05/09 International Journal of Molecular Science MDPI
2023/04/11 - 2023/04/11 Biomedicines MDPI
2023/04/04 - 2023/04/06 International Journal of Molecular Sciences MDPI
2023/03/22 - 2023/03/23 International Journal of Molecular Sciences MDPI
2022/09/25 - 2022/09/28 European Journal of Pharmacology
2022/07/26 - 2022/07/28 European Journal of Pharmacology
2021/11/20 - 2021/12/02 Frontiers in Neural Circuits
2021/10/21 - 2021/10/24 Frontiers in Human Neuroscience
2021/02/24 - 2021/02/24 Behavioural Brain Research Elsevier
2020/12/14 - 2020/12/14 Behavioural Brain Research Elsevier
2020/11/05 - 2020/11/05 Neurotherapeutics Springer Nature
2020/10/14 - 2020/10/14 Molecular Pain Springer Nature
2020/07/06 - 2020/07/06 Neuroscience Letters Elsevier
2019/10/17 - 2019/10/18 Neuroscience Letters (0304-3940) Elsevier

Association member

Society Organization name Role
2012/10/01 - Current SFN - Society for Neuroscience Member
2002/06/01 - Current SPN - Portuguese Society for Neuroscience Effective member
1998/09/01 - Current Ordem dos Biólogos (Biologist Order) Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2015/09/01 - Current FMUP - Neurobiology master course, First year module: "Neural circuits identification" Laboratorial practice; 4 hours/year Neurobiologia (Mestrado integrado) Universidade do Porto - Faculdade de Medicina, Portugal
2015/09/01 - Current FMUP - Neurobiology master course, First year module: "Thesis project preparation" Neurobiologia (Mestrado integrado) Universidade do Porto - Faculdade de Medicina, Portugal
2015/09/01 - Current FMUP - International doctoral program in Neuroscience, iPDN Invited External Teacher; First year module, "Methodological approaches in neurosciences" - Laboratorial practice Neurociências (Doutoramento) Universidade do Porto - Faculdade de Medicina, Portugal

Interview (tv / radio show)

Program Topic
2015 - Current Ponto de Partida A dor e a Memória

Mentoring / Tutoring

Topic Student name
2022/02/07 - 2022/02/24 Laboratory rotation - "The effect of chronic pain on cognitive function" Matilde Silva

Other jury / evaluation

Activity description Institution / Organization
2022/11/25 - Current Selected to the pool of reviewers to evaluate the funding call: "Networking Group Call 2022 - Chronic Pain" ERA-NET Neuron: The Network of European Funding for Neuroscience Research
2024/05/24 - 2024/05/28 UKRI Medical Research Council - Career Development Award, April 2024. Role: Individual applicant proposal reviewer UKRI Medical Research Council, United Kingdom
Distinctions

Award

2020 Best Poster Communication - Health Sciences, 13th IJUP Meeting, University of Porto, Portugal.
Universidade do Porto, Portugal
2017 SPN - Best Poster Award in panel "Neural circuits and behavior"
Sociedade Portuguesa de Neurociências, Portugal
2015 First Prize by Grünenthal Foundation for Basic Research in Pain
Grünenthal Foundation , Portugal
2014 SPN - Prémio artigo destaque - Categoria "Neurofisiologia de Sistemas e Comportamento"
Sociedade Portuguesa de Neurociências, Portugal
2012 Best Basic Research Paper in Pain
Revista DOR/Bene, Portugal
2012 First Prize by Grünenthal Foundation for Basic Research in Pain
Grünenthal Foundation , Portugal
2011 Honorable Mention by Grünenthal Foundation for Basic Research in Pain
Grünenthal Foundation , Portugal
2011 Best Neuroscience poster at I3S – Scientific Retreat 2011
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2008 Travel grant - FENS Fórum Geneva 2008
Sociedade Portuguesa de Neurociências, Portugal
2007 Honorable Mention by Grünenthal Foundation for Basic Research in Pain
Grünenthal Foundation , Portugal
2004 First Prize by Grünenthal Foundation for Basic Research in Pain
Grünenthal Foundation , Portugal

Revista DOR/Bene, Portugal

Other distinction

2023 Neurology International Journal - Selected Cover of Volume 15, Issue 4 (December 2023)
2022 Assistent Researcher - Individual Call to Scientific Employment Stimulus - 5th Edition
Fundação para a Ciência e a Tecnologia, IP., Portugal
2014 Postdoctoral grant
Fundação para a Ciência e a Tecnologia, IP, Portugal
2010 Paper selected and evaluated by Eberhard Kochs - F1000 Medicine
F1000 Research Ltd, United Kingdom
2007 Doctoral grant
Fundação para a Ciência e a Tecnologia, IP, Portugal
2001 Scholar Merit Award
Universidade do Minho, Portugal
2000 Scholar Merit Award
Universidade do Minho, Portugal