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Ana Henriques graduated from the Faculty of Sciences and Technology of the University of Coimbra, with a Master’s Degree in Biochemistry (2012), and a Bachelor’s Degree in Biochemistry (2010). Her Master’s Degree was concluded under the thesis entitled “Infection by hepatitis C virus - genetic variability and molecular studies of immune response mediators”, at the Center Histocompatibility Center (Coimbra). Still, in the scope of academic training, she did a volunteer internship (2012) at the Institute for Biomedical Imaging and Life Sciences (IBLI), in the field of nuclear oncology. In November 2022, Ana concluded her PhD (PhD fellowship from FCT 2016 call - SFRH/BD/116167/2016) at the University Institute of Health Sciences (IUCS) – CESPU, within the Biomedical Sciences doctoral program. Her PhD work was focused on developing novel molecular-based therapies targeting key mitotic regulators and searching for combination approaches to kill or increase the sensitivity of cancer cells to antimitotics. During her professional / academic journey, Ana also worked as a research fellow in the study of genes responsible for the use of methanesulfonate (MSA) as a carbon and energy source in MSA-isolated bacteria and seawater samples (2013-2015) at the Institute for Research and Advanced Training in Health sciences and Technologies (IINFACTS) – CESPU. After that, she was a research fellow at the Faculty of Engineering of the University of Porto (2016) in the context of studies involving environmental multidrug-resistant bacteria. More recently, Ana worked as a temporary Staff Scientist (maternity leave substitute) at IFOM (Milan), in the DNA damage response and cellular senescence Lab. Currently, Ana is working as a Postdoc in Cell Biology of Viral Infection Research Lab at Católica Biomedical Research Centre (01/09/2024 - current) / Instituto Gulbenkian de Ciência (01/07/2023 - 31/08/2024), where she is dedicated to investigating the molecular mechanisms underlying influenza virus infections. Research interests: cancer, targeted therapies, microbiology, mitosis, aging.
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Identification

Personal identification

Full name
Ana Cristina do Espírito Santo Henriques
Gender
Female

Citation names

  • Henriques, Ana C.

Author identifiers

Ciência ID
6C13-DE40-98D1
ORCID iD
0000-0002-4951-792X

Email addresses

  • anhenriques@ucp.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Italian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Elementary (A2) Beginner (A1) Elementary (A2)
Education
Degree Classification
2024/03/04 - 2024/03/06
Concluded
 3rd Edition of the Macro Scripting in ImageJ Course (Outros)
Major in 3rd Edition of the Macro Scripting in ImageJ Course
Universidade Nova de Lisboa Medical School, Portugal
2024/01/30 - 2024/02/15
Concluded
 Data Scientist com R (Outros)
GADES data analysis solutions and CEAUL (Centro de Estatística e Aplicações Universidade Nova de Lisboa), Portugal
2017/03/01 - 2022/11/04
Concluded
 Ciências Biomédicas (Doutoramento)
Instituto Universitário de Ciências da Saúde, Portugal
"Therapeutic targeting of spindle assembly checkpoint silencing as a strategy to sensitize cancer cells to chemotherapy drugs" (THESIS/DISSERTATION)
2018/05/07 - 2018/05/19
Concluded
 Course in Laboratory Animal Science - Category C FELASA (Federation for European Laboratory Animal Science Assocations) (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/07/16 - 2014/07/17
Concluded
 Workshop: Liquid and Gas Chromatography - Principles and Applications (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2012/09
Concluded
 Bioquímica (Mestrado integrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Infeção pelo vírus da hepatite C - variabilidade genética e estudo molecular de mediadores da resposta imune" (THESIS/DISSERTATION)
 17
2007/09 - 2010/07
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Aterosclerose e Infeção - efeitos de LDL (Low Density Lipoprotein) e CHEMS (Cholesteryl Hemisuccinate) em Macrófagos" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2024/09/01 - Current Postdoc (Research) Universidade Católica Portuguesa, Portugal
2023/07 - 2024/08/31 Postdoc (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2022/04/20 - 2023/01/20 Research Assistant (Research) IFOM-IEO Campus, Italy
IFOM-IEO Campus, Italy
2012/09/01 - 2012/10/01 Research Trainee (Research) IBILI - Instituto Biomédico de Investigação da Luz e da Imagem, Portugal
2011/09/01 - 2012/09/01 Research Trainee (Research) Hospitais da Universidade de Coimbra Centro de Histocompatibilidade do Centro, Portugal
2010/02/01 - 2010/07/01 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution 		Employer
2017/02/08 - 2022/11/04 PhD Student - FCT fellowship (reference: SFRH/BD/116167/2016) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
(...)
2016/02/08 - 2016/08/07 Research Fellow Universidade do Porto Faculdade de Engenharia, Portugal
2013/06/01 - 2015/08/31 Research Fellow Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Projects

Grant

Designation Funders
2017/03 - 2021/03 Therapeutic targeting of cell division through functionalized nanoparticle-mediated siRNA delivery for the treatment of lung cancer.
SFRH/BD/116167/2016
PhD Student Fellow
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Ongoing
2016/02 - 2016/08 Investigation of the photocatalytic inactivation of multidrug resistant Escherichia coli of the sequence type ST131 complex
LEPABE-EQU/00511
Research Fellow
Universidade do Porto Faculdade de Engenharia, Portugal
 Universidade do Porto Faculdade de Engenharia
Concluded
2013/06 - 2015/08 Methanesulfonate-degrading marine bacteria: a molecular approach
PTDC/BIA-MIC/3623/2012
Research Fellow
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2018 - 2021 Molecular mechanisms of chromosome segregation.
030014 (Call: 02/SAICT/2017)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Universidade do Algarve - Campus de Gambelas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019 - 2020 Targeting the mitotic protein p31comet for cancer therapy.
ComeTax
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Ongoing
2018 - 2019 Bub3 and Spindly knockout mediated by CRISPR-Cas9 technology: in vitro characterization and therapeutic potential
CRISPRTech
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Ongoing
2017 - 2018 The mitotic protein p31comet as a cancer therapeutic target
ComeTarget
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
Outputs

Publications

Conference poster
  1. Henriques, Ana; Silva, Patrícia; Sarmento, Bruno; Bousbaa, Hassan. "A inibição da molécula p31comet sensibiliza células de cancro de pulmão de não-pequenas células ao tratamento com paclitaxel". Paper presented in 1º Encontro Nacional de Jovens Investigadores em Oncologia, 2019.
  2. Henriques, Ana C. (6C13-DE40-98D1); Silva, Patrícia; Sarmento, Bruno; Bousbaa, Hassan. "Targeting p31comet sensitizes non-small cell lung cancer cells to paclitaxel treatment". Paper presented in GenomePT Syposium, 2019.
  3. Bousbaa, Hassan; Cidade, Honorina; Pinto, Patrícia; Machado, Carmen Mariana; Moreira, Joana; P. Almeida, José Diogo; M. A. Silva, Patrícia; et al. "New chalcone derivatives with suitable drug-like lipophilicity targeting mitosis". 2019.
    10.3390/ecmc2019-06311
  4. Henriques, Ana C.; De Marco, Paolo. "Simple Protocol for Molecular Fingerprinting of Human Oral Microbiota Samples in Lab Classes". Paper presented in 7th Congress of European Microbiologists (FEMS 2017 Congress), 2017.
  5. Henriques, Ana C.; De Marco, Paolo. "Genes and genomes of methanesulfonate-degrading bacteria". Paper presented in Gordon Research Conference on Applied & Environmental Microbiology, 2015.
  6. Henriques, Ana C.; De Marco, Paolo. "Methanesulfonate (MSA) catabolic genes from marine and estuarine bacteria". Paper presented in 6th Congress of European Microbiologists (FEMS 2015 Congress), 2015.
  7. Henriques, Ana C. (6C13-DE40-98D1); De Marco, Paolo. "Methanesulfonate-degrading marine bacteria: a molecular approach". Paper presented in Gordon Research Conference on Marine Microbes, 2014.
  8. Henriques, Ana C.; De Marco, Paolo. "Methanesulfonate-degrading marine bacteria: a molecular approach". Paper presented in MicroBiotec 13, 2013.
Journal article
  1. Henriques, Ana C.; Silva, João P. N.; Pinto, Bárbara; Silva, Patrícia M. A.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Exploring the Clinical Relevance of p31comet in Head and Neck Squamous Cell Carcinoma through UALCAN database analysis". Scientific Letters (2024): https://doi.org/10.48797/sl.2024.266.
    Published
  2. Silva, Patrícia M. A.; Henriques, Ana C.; Silva, João Pedro Nunes; Pinto, Bárbara; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Targeting p31comet to Enhance Cisplatin-induced Cytotoxicity in Oral Squamous Cell Carcinoma Cells". Scientific Letters (2024): https://doi.org/10.48797/sl.2024.121.
    Published
  3. Gioia, Ubaldo; Tavella, Sara; Martínez-Orellana, Pamela; Cicio, Giada; Colliva, Andrea; Ceccon, Marta; Cabrini, Matteo; et al. "SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence". Nature Cell Biology (2023): http://dx.doi.org/10.1038/s41556-023-01096-x.
    10.1038/s41556-023-01096-x
  4. Pinto, Bárbara; Novais, Pedro; Henriques, Ana C.; Carvalho-Tavares, Juliana; Silva, Patrícia M. A.; Bousbaa, Hassan. "Navitoclax Enhances the Therapeutic Effects of PLK1 Targeting on Lung Cancer Cells in 2D and 3D Culture Systems". Pharmaceutics 14 6 (2022): 1209. http://dx.doi.org/10.3390/pharmaceutics14061209.
    Published • 10.3390/pharmaceutics14061209
  5. De Marco, Paolo; Henriques, Ana C.; Azevedo, Rui; Sá, Susana I.; Cardoso, Armando; Fonseca, Bruno; Barbosa, Joana; Leal, Sandra. "Gut Microbiome Composition and Metabolic Status Are Differently Affected by Early Exposure to Unhealthy Diets in a Rat Model". Nutrients 13 9 (2021): 3236. http://dx.doi.org/10.3390/nu13093236.
    10.3390/nu13093236
  6. Henriques, Ana C.; Silva, Patrícia M. A.; Sarmento, Bruno; Bousbaa, Hassan. "Antagonizing the spindle assembly checkpoint silencing enhances paclitaxel and Navitoclax-mediated apoptosis with distinct mechanistic". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-83743-7.
    10.1038/s41598-021-83743-7
  7. Henriques, Ana; Silva, Patrícia M. A.; Sarmento, Bruno; Bousbaa, Hassan. "The Mad2-Binding Protein p31comet as a potential target for human cancer therapy". Current Cancer Drug Targets 21 (2021): http://dx.doi.org/10.2174/1568009621666210129095726.
    10.2174/1568009621666210129095726
  8. Loureiro, Daniela R. P.; Magalhães, Álvaro F.; Soares, José X.; Pinto, Joana; Azevedo, Carlos M. G.; Vieira, Sara; Henriques, Ana; et al. "Yicathins B and C and Analogues: Total Synthesis, Lipophilicity and Biological Activities". ChemMedChem 15 9 (2020): 749-755. http://dx.doi.org/10.1002/cmdc.201900735.
    10.1002/cmdc.201900735
  9. Pinto, B.; Henriques, A.C.; Silva, P.M.A.; Bousbaa, H.. "Three-dimensional spheroids as in vitro preclinical models for cancer research". Pharmaceutics 12 12 (2020): 1-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-85097385948&partnerID=MN8TOARS.
    10.3390/pharmaceutics12121186
  10. França, F.; Silva, P.M.A.; Soares, J.X.; Henriques, A.C.; Loureiro, D.R.P.; Azevedo, C.M.G.; Afonso, C.M.M.; Bousbaa, H.. "A Pyranoxanthone as a Potent Antimitotic and Sensitizer of Cancer Cells to Low Doses of Paclitaxel". Molecules (Basel, Switzerland) 25 24 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85098532620&partnerID=MN8TOARS.
    10.3390/molecules25245845
  11. Pinto, Patricia; Machado, Carmen Mariana; Moreira, Joana; Almeida, José Diogo P.; Silva, Patrícia M.A.; Henriques, Ana C.; Soares, José X.; et al. "Chalcone derivatives targeting mitosis: Synthesis, evaluation of antitumor activity and lipophilicity". European Journal of Medicinal Chemistry (2019): 111752. http://dx.doi.org/10.1016/j.ejmech.2019.111752.
    10.1016/j.ejmech.2019.111752
  12. Henriques, A.C.; Ribeiro, D.; Pedrosa, J.; Sarmento, B.; Silva, P.M.A.; Bousbaa, H.. "Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution". Cancer Letters 440-441 (2019): 64-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054927966&partnerID=MN8TOARS.
    10.1016/j.canlet.2018.10.005
  13. Henriques, Ana C.; De Marco, Paolo. "Simple Protocol for Molecular Fingerprinting of Human Oral Microbiota Samples in Lab Classes". Journal of Microbiology & Biology Education 19 1 (2018): http://dx.doi.org/10.1128/jmbe.v19i1.1305.
    10.1128/jmbe.v19i1.1305
  14. Henriques, Ana C.; Azevedo, Rui M.S.; De Marco, Paolo. "Metagenomic survey of methanesulfonic acid (MSA) catabolic genes in an Atlantic Ocean surface water sample and in a partial enrichment". PeerJ 4 (2016): e2498. http://dx.doi.org/10.7717/peerj.2498.
    10.7717/peerj.2498
  15. Henriques, Ana C.; De Marco, Paolo. "Methanesulfonate (MSA) Catabolic Genes from Marine and Estuarine Bacteria". PLOS ONE 10 5 (2015): e0125735. http://dx.doi.org/10.1371/journal.pone.0125735.
    10.1371/journal.pone.0125735
  16. Henriques, A.C.; De Marco, P.. "Complete genome sequences of two strains of "Candidatus Filomicrobium marinum," a methanesulfonate-degrading species". Genome Announcements 3 3 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-85008466245&partnerID=MN8TOARS.
    10.1128/genomeA.00160-15
  17. Henriques, A.C.; De Marco, P.. "Genome sequence of Rhodococcus sp. strain RD6.2 DSM 46800, a methanesulfonate-degrading strain". Genome Announcements 3 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-85008469073&partnerID=MN8TOARS.
    10.1128/genomeA.00730-15
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/11/26 Interferindo com a proteína p31comet aumenta a citotoxicidade do palitaxel e do Navitoclax em esferóides do cancro do pulmão 4ª rRACS 2021 - 3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia
Rede Académica das Ciências da Saúde da Lusofonia (Benguela, Angola)
2020/10/13 p31comet inhibition combined with low doses of paclitaxel or Navitoclax potentiates cancer cell death PhD Day - Programa Doutoral em Ciências Biológicas Aplicadas à Saúde
Instituto Universitário de Ciências da Saúde (Gandra, Portugal)
2020/09/24 A combinação da inibição da p31comet com doses clinicamente relevantes de paclitaxel ou Navitoclax potencia a morte de células de cancro de pulmão de não pequenas células 2º Encontro Nacional de Jovens Investigadores em Oncologia
Liga Portuguesa Contra o Cancro, Núcleo Regional do Norte (Porto, Portugal)
2020/09 Poderá a p31comet constituir um alvo molecular para a sensibilização de células de cancro de pulmão de não pequenas células ao paclitaxel? rRACS 2020 - 3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia
Rede Académica das Ciências da Saúde da Lusofonia (Portugal)
2019/11/20 New chalcone derivatives with antimitotic activity: synthesis, antitumor activity evaluation and chemosensitivity studies. XXV Encontro Galego-Portugues de Química
XXV Encontro Galego-Portugues de Química (Santiago de Compostela, Spain)
2019/07/04 Targeting p31comet sensitizes non-small cell lung cancer cells to paclitaxel treatment. PhD Day - Programa Doutoral em Ciências Biológicas Aplicadas à Saúde
Instituto Universitário de Ciências da Saúde, CESPU (Gandra, Portugal)
2012/12/15 Infecção pelo vírus de Hepatite C - Estudo molecular de mediadores da resposta imune XI Congresso Nacional de Doenças Infecciosas e Microbiologia e IX Congresso Naconal sobre Sida.
(Porto, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/07/20 - 2017/07/20 VII IINFACTS Workshop - The organization of this event aimed to disseminate the latest research carried out at the IINFACTS unit to the CESPU scientific community to promote peer discussion, as well as enhance future collaborations between the elements involved in these areas of interest. (2017/07/20 - 2017/07/20) Instituto Universitário de Ciências da Saúde, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/10/01 - 2022/02/28 Molecular and Cell Biology Practical Classes Ciências da Nutrição (Licenciatura) Instituto Universitário de Ciências da Saúde, Portugal
2021/10/01 - 2022/02/28 Molecular and Cell Biology Practical Classes Ciências Biomédicas (Licenciatura) Instituto Universitário de Ciências da Saúde, Portugal