María Gómez Lázaro (6C16-CBE0-4A45)

Curriculum Vitae

María Gómez Lázaro

María Gómez Lázaro graduated in Biochemistry from the University of Valencia (Valencia, Spain) in 2002. Got her MSc at the Universidad de Navarra on Research, development and innovation of Novel Drugs, from the Faculty of Pharmacy in 2003. She got her PhD, in 2007, in Medical Sciences (Pharmacology) from the Faculty of Medicine from the Universidad de Castilla-La Mancha (Albacete, Spain), and another master degree on Neuroscience and behavioural biology, from the Universidad Pablo de Olavide (Seville, Spain). In 2007 she moved to the Centro de Biologia Celular from the University of Aveiro (Aveiro, Portugal) as a postdoc. Later in 2011, she worked as a postdoc researcher on the Instituto de investigación en Discapacidades Neurológicas (IDINE) from the Universidad de Castilla-La Mancha (Albacete, Spain). Finally, in 2012 she joined INEB where she is the Head of the Bioimaging Scientific Platform of i3S - Instituto de Investigação e Inovação em Saúde (Universidade do Porto, Porto, Portugal), where she is expert on laser scanning confocal microscopy, microcomputed tomography (microcT) both ex vivo and in vivo, imaging flow cytometry, and confocal Raman spectroscopy. Published 36 articles in journals. Has 6 section(s) of books. Organized 11 event(s). Supervised 1 PhD thesis(es). Has received 6 awards and/or honors. Participates and/or participated as PhD Student Fellow in 7 project(s), Post-doc Fellow in 4 project(s) and Researcher in 6 project(s). At the PPBI project she is responsible for the management of the budget attributed to INEB. Works in the area(s) of Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism, Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Neurosciences, Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry, Medical and Health Sciences with emphasis on Basic Medicine, Exact Sciences with emphasis on Computer and Information Sciences with emphasis on Bioinformatics and Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Health Sciences; neurodegeneration; apoptosis; neuronal death; mitochondria; neuroprotection; Parkinson's disease; ischemic neuronal death; primary cells; Huntington's disease; Alzheimer's disease; cellular biology; microscopy; astrocytes; cell signaling; oncobiology; proteomics; oxidative stress; immunofluorescence; cell culture; biochemistry; flow cytometry; imaging flow cytometry; Raman microscoppy; animal model; peroxisomes; pancreatitis; cell biology; biomaterials; degeneration; immune system; therapy; cytoscape; proteome profiling; angiogenesis; synaptic plasticity; nanoparticles; extracellular matrix; regeneration; bone; microCT; image analysis; high-throughput screening; atomic force microscopy; animal models for neurodegenerative diseases; animal models; infection; bioengineering; endothelial; imaging; confocal microscopy; microultrasounds; .

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Identification

Personal identification

Full name: María Gómez Lázaro

Citation names

Gomez-Lazaro, Maria

Author identifiers

Ciência ID: 6C16-CBE0-4A45
ORCID iD: 0000-0002-8836-396X

Email addresses

maria.glazaro@ineb.up.pt (Professional)
maria.glazaro@i3s.up.pt (Professional)

Addresses

i3S- Instituto de Investigação em Inovação e Saúde, Rua Alfredo Allen,208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

www.i3s.up.pt (Professional)

Knowledge fields

Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
Medical and Health Sciences - Basic Medicine - Neurosciences
Natural sciences - Biological Sciences - Biochemistry
Medical and Health Sciences - Basic Medicine
Exact Sciences - Computer and Information Sciences - Bioinformatics
Natural sciences - Biological Sciences - Cell Biology
Natural sciences - Biological Sciences - Biochemistry

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Spanish; Castilian (Mother tongue)
English	Upper intermediate (B2)	Upper intermediate (B2)	Advanced (C1)	Upper intermediate (B2)	Advanced (C1)
Portuguese	Upper intermediate (B2)	Advanced (C1)	Upper intermediate (B2)	Advanced (C1)	Upper intermediate (B2)
German	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)
Catalan	Elementary (A2)	Intermediate (B1)	Beginner (A1)	Elementary (A2)	Beginner (A1)

Education

	Degree	Classification
2019/02/05 - 2019/02/05 Concluded	HANDS-ON NECROPSY WORKSHOP: LABORATORY MICE AND RATS (Outros) Major in animal research experimentation Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/10/10 - 2016/10/11 Concluded	Introduction to data analysis & images processing with MATLAB (Especialização pós-licenciatura) Major in image analysis Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/09/13 - 2016/09/16 Concluded	BioImage Analysis for Core Facility Staff (Outros) Major in Image analysis, microscopy Universitat Pompeu Fabra Departament de Tecnologies de la Informació i les Comunicacions, Spain
2016/02/12 - 2016/04/22 Concluded	Quantitative data analysis with SPSS (Outros) Major in Medical Sciences - statistics Universidade Católica Portuguesa Instituto de Ciências da Saúde Porto, Portugal
2013/02/19 - 2013/02/19 Concluded	Training on suture techniques for mice and rats (Outros) Major in animal experimentation Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2013/01/29 - 2013/01/29 Concluded	3D Raman Imaging Meets AFM and Profilometry. Chemical and Structural Material Characterization from the Nano to the Millimeter Range (Outros) Major in Raman microscopy International Iberian Nanotechnology Laboratory, Portugal
2012/11/22 - 2013/01/16 Concluded	Laboratory Animal Science Course. Category C (Outros) Major in animal experimentation Fundación General Universidad de Granada Empresa, Spain
2008/07 - 2008/08 Concluded	Hands on course in proteins and proteomics (Curso de Especialização Tecnológica) Universidade Nova de Lisboa, Portugal
2007/07 - 2007/07 Concluded	Hands on course on Proteomics: Techniques and applications (Curso de Especialização Tecnológica) Universidad Complutense de Madrid, Spain
2004/01/08 - 2007/06 Concluded	PhD in medical Sciences (Doktor (PhD)) Major in Pharmacology and biomedicine Universidade de Castilla-La Mancha- Faculdade de Medicina, Spain "Molecular and cellular mechanisms involved in the modulation of the mitochondrial membranes permeability in different models of Neurological diseases" (THESIS/DISSERTATION)	Suma Cum Laude
2005 - 2005 Concluded	Master On-Line in Neuroscience and behavioral biology (Mestrado) Major in Neurosciences Universidad Pablo de Olavide, Spain
2004 - 2004 Concluded	Diploma de estudos avançados: PhD program on “Design, Synthesis and Biological evaluation of Medicaments”. (DEA) Major in pharmacology Universidad de Navarra Departamento de Química Orgánica y Farmacéutica, Spain
2002/09 - 2003/12 Concluded	Master degree in Research, development and innovation of Novel Drugs (Mestrado) Major in Pharmacology Universidad de Navarra Departamento de Química Orgánica y Farmacéutica, Spain "Development of an Experimental assay for the evaluation of the telomerase inhibitory activity of new anticancer compounds" (THESIS/DISSERTATION)	20
2003/07 - 2003/07 Concluded	Specialist in Bioinformatics: Genomics and Proteomics (Curso de Especialização Tecnológica) Universidad Complutense de Madrid, Spain
1997/09/01 - 2002/06/30 Concluded	Bioquímica (Licence) Major in Bioquímica Universitat de Valencia Departament de Bioquímica i Biologia Molecular, Spain	14

Affiliation

Science

	Category Host institution	Employer
2011/04 - 2012/09	Postdoc (Research)	Universidad de Castilla-La Mancha, Spain
	Universidade de Castilla-La Mancha - Instituto de Investigación en Discapacidades Neurológicas (IDINE), Spain
2007/08 - 2011/03	Postdoc (Research)	Universidade de Aveiro, Portugal
	Universidade de Aveiro - Centro de Biologia Celular, Portugal

Others

	Category Host institution	Employer
2023/01/01 - Current	Técnico Superior (Bioimaging Scientific Platform Head)	i3s - Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação, Portugal

2012/10/01 - 2022/12/31	Técnico Superior (Bioimaging Scientific Platform Head)	Instituto Nacional de Engenharia Biomédica, Portugal

2004/01 - 2007/06	Aluno doutoramento	Universidad de Castilla-La Mancha Centro Regional de Investigaciones Biomédicas, Spain
	Universidad de Castilla-La Mancha Centro Regional de Investigaciones Biomédicas, Spain

Projects

Grant

	Designation	Funders
2021 - 2024	EndoSWITCH - Harnessing endothelial plasticity for therapeutic revascularization of ischemic tissues: a bioengineering approach PTDC/BTM-ORG/5154/2020 Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Centro Interuniversitário de História das Ciências e da Tecnologia Ongoing
2018/07/26 - 2021/06/25	GLYcanMATRIX - Targeting the cancer cell and extracellular matrix glycan's dynamics for impairment of tumour progression POCI-01-0145-FEDER-028489 Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/06/01 - 2021/05/31	PPBI - Portuguese Platform of BioImaging PPBI-POCI-01-0145-FEDER-022122 Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal INEB - Instituto Nacional de Engenharia Biomédica, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2012 - 2014	NMDA-Independent synaptic plasticity in the hippocampus BFU2011-26339 Researcher Universidade de Castilla-La Mancha - Instituto de Investigación en Discapacidades Neurológicas (IDINE), Spain	Gobierno de España Ministerio de Ciencia e Innovación Concluded
2011/04 - 2012/09	Synaptic plasticity mechanisms in Parkinson’s disease 2011 Post-doc Fellow Universidade de Castilla-La Mancha - Instituto de Investigación en Discapacidades Neurológicas (IDINE), Spain	Gobierno de España Ministerio de Ciencia e Innovación Concluded
2009 - 2012	Neuroprotective role of astrocytes in Parkinson’s disease PII1I09-0087-1578 Researcher Universidad de Castilla-La Mancha - Facultad de Medicina - Centro Regional de Investigaciones Biomédicas, Spain	Junta de Comunidades de Castilla-La Mancha Concluded
2009/02/01 - 2011/03/31	GRANULE BIOGENESIS IN THE EXOCRINE PANCREAS: IDENTIFICATION AND MOLECULAR CHARACTERIZATION OF THE COMPONENTS OF A SUBMEMBRANOUS GRANULE MATRIX SFRH/BPD/37725/2007	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2011/03	Granule Biogenesis in the exocrine pancreas. Identification and molecular characterization of the components of the submembranous granule matrix SFRH/BPD/37725/2007 Post-doc Fellow Universidade de Aveiro - Centro de Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2009	Granule Biogenesis in the exocrine pancreas. Identification and molecular characterization of the components of the submembranous granule matrix 2008 Post-doc Fellow Universidade de Aveiro - Centro de Biologia Celular, Portugal	Junta de Comunidades de Castilla-La Mancha Concluded
2007 - 2009	Biogenesis of peroxisomes: Identification and characterization of the molecular machinery required for the growth and division of peroxisomes PTDC/BIA-BCM/71932/2006 Researcher Universidade de Aveiro - Centro de Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007 - 2007	Molecular and cellular mechanisms involved in the modulation of the mitochondrial membranes permeability in different models of Neurological diseases 2007 PhD Student Fellow Universidad de Castilla-La Mancha - Facultad de Medicina - Centro Regional de Investigaciones Biomédicas, Spain	Universidad de Castilla-La Mancha - Campus de Albacete Concluded
2007 - 2007	Study of the involvement of the mitochondria and peroxisomes in the 6-OHDA-induced cell death 2007 PhD Student Fellow Institut für Zytologie und Zytopathologie, Marburg, Germany, Germany	Universidad de Castilla-La Mancha - Campus de Albacete Concluded
2004 - 2007	Molecular and cellular mechanisms involved in the modulation of the mitochondrial membranes permeability in different models of Neurological diseases 2004 PhD Student Fellow Universidad de Castilla-La Mancha - Facultad de Medicina - Centro Regional de Investigaciones Biomédicas, Spain	Junta de Comunidades de Castilla-La Mancha Concluded
2006 - 2006	Molecular and cellular mechanisms involved in the modulation of the mitochondrial membranes permeability in different models of Neurological diseases 2006 PhD Student Fellow Universidad de Castilla-La Mancha - Facultad de Medicina - Centro Regional de Investigaciones Biomédicas, Spain	Universidad de Castilla-La Mancha - Campus de Albacete Concluded
2005 - 2005	Molecular and cellular mechanisms involved in the modulation of the mitochondrial membranes permeability in different models of Neurological diseases 2005 PhD Student Fellow Universidad de Castilla-La Mancha - Campus de Albacete, Spain	Universidad de Castilla-La Mancha - Campus de Albacete Concluded
2002 - 2005	p53 regulation as pharmacological target in neuronal death processes SAF2002-04721 PhD Student Fellow Universidad de Castilla-La Mancha - Facultad de Medicina - Centro Regional de Investigaciones Biomédicas, Spain	Junta de Comunidades de Castilla-La Mancha Concluded

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	Institute for Research and Innovation in Health LA/P/0070/2020 Instituto Nacional de Engenharia Biomédica, Portugal Universidade do Porto, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Institute for Research and Innovation in Health LA/P/0070/2020 10.54499/LA/P/0070/2020 Instituto de Astrofísica e Ciências do Espaço, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - 2024/12/31	JumpIN - HiJacking the peripheral neurons retrograde trafficking machinery to deliver neUroprotective Molecules to sPinal cord InterNeurons PTDC/BTM-MAT/4156/2021 10.54499/PTDC/BTM-MAT/4156/2021 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal International Iberian Nanotechnology Laboratory, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/03/29 - 2024/09/28	Harnessing endothelial plasticity for therapeutic vascularization of ischemic tissues: a bioengineering approach PTDC/BTM-ORG/5154/2020 10.54499/PTDC/BTM-ORG/5154/2020 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/26 - 2022/01/25	Targeting the cancer cell and extracellular matrix glycan's dynamics for impairment of tumour progression PTDC/MED-ONC/28489/2017 Instituto Nacional de Engenharia Biomédica, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/26 - 2022/01/25	Targeting the cancer cell and extracellular matrix glycan's dynamics for impairment of tumour progression PTDC/MED-ONC/28489/2017 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Instituto de Investigação e Inovação em Saúde UID/BIM/04293/2019 Instituto Nacional de Engenharia Biomédica, Portugal Universidade do Porto, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Institute for Research and Innovation in Health Sciences UID/BIM/04293/2019 Instituto de Astrofísica e Ciências do Espaço, Portugal Universidade do Porto, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/01/01 - 2014	Strategic Project - LA 2 - 2013-2014 STRATEGIC PROJECT LA 2 - 2013-2014. PEst-C/SAU/LA0002/2013 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2013/12/31	Strategic Project - UI 482 - 2011-2012 PEst-OE/SAU/UI0482/2011 Universidade de Aveiro, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2012	STRATEGIC PROJECT: UI 482 - 2011-2012 UI 482 - 2011-2012 Post-doc Fellow Universidade de Aveiro - Centro de Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/01/01 - 2010/12/31	Biogenesis of peroxisomes: Identification and characterization of the molecular machinery required for the growth and division of peroxisomes PTDC/BIA-BCM/71932/2006 Universidade de Aveiro, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2007	Molecular and cellular mechanisms as possible pharmacological targets in a Parkinson’s disease model 04005-00 PhD Student Fellow Universidad de Castilla-La Mancha - Facultad de Medicina - Centro Regional de Investigaciones Biomédicas, Spain	Junta de Comunidades de Castilla-La Mancha Concluded

Outputs

Publications

Book chapter	Maia, André; Gomez-Lazaro, Maria. "High-Content Microscopy". In A compendium of imaging modalities for biological & preclinical research as part of the IOP-IPEM ebook Series in Physics and Engineering in Medicine and Biology to be published by IOP Publishing Ltd which trades as IOP Publishing of Temple Circus, Temple Way, Bristol BS1 6HG, UK.. Bristol, United Kingdom: IOP Publishing Ltd, 2020. Accepted Gomez-Lazaro, Maria; Haberthuer, David; Hlushchuk, Ruslan. "Computer tomography in Biomedicine". In A compendium of imaging modalities for biological & preclinical research as part of the IOP-IPEM ebook Series in Physics and Engineering in Medicine and Biology to be published by IOP Publishing Ltd which trades as IOP Publishing of Temple Circus, Temple Way, Bristol BS1 6HG, UK.. United Kingdom: IOP Publishing Ltd, 2020. Under revision Gomez-Lazaro, Maria; Aroso, Miguel. "Confocal microscopy in the life sciences". In Fluorescence Imaging and Biological Quantification, edited by Seruca, Raquel; Jasjit S. Suri; Sanches, Miguel J, 3-24. Boca Raton, United States: CRC Press, 2017. Published Gomez-Lazaro, Maria; Freitas, Ana; Ribeiro, Cristina C. "Confocal Raman microscopy. Imaging the chemistry". In Fluorescence Imaging and Biological Quantification, edited by Seruca, Raquel; Jasjit S. Suri; Sanches, Miguel J, 65-83. Boca Raton, United States: CRC Press, 2017. Published Bonekamp, Nina A.; Islinger, Markus; Gomez-Lazaro, Maria; Schrader, Michael. "Cytochemical Detection of Peroxisomes and Mitochondria". In Methods in Molecular Biology, 467-482. New York, United States: Humana Press, 2012. Accepted • 10.1007/978-1-62703-056-4_24 Gomez-Lazaro, Maria; Aroso, Miguel; Schrader, Michael. "Rab8". In Pancreapedia: Exocrine Pancreas Knowledge Base,. 2011. Published • 10.3998/panc.2011.2
Conference poster	Patrícia C. Henriques; Costa, Lia; Sampaio, Paula; Gomez-Lazaro, Maria; Maia, André; Martins, M. Cristina L.; Costa, Paulo; Gonçalves, Inês. "Exploring bioimaging strategies to study chitosan microspheres interaction with gastric mucosa.". Paper presented in BioImaging 2015 - 4th International Symposium in applied Bioimaging: The Pre-Clinical Challenge in 3D, 2015. Marina, Leite; Marques, MS; Gomez-Lazaro, Maria; Ferreira, RM; Melo, Joana; Pinto, MT; Seruca, Raquel; Figueiredo, Ceu. "Helicobacter pylori activates the EphA2 receptor in gastric epithelial cells to modulate the angiogenic response". Paper presented in 4th I3S Annual Meeting, 2014. Henriques, Patrícia C.; Sampaio, Paula; Gomez-Lazaro, Maria; Maia, André; Gouveia, António; Lopes, José Manuel; Magalhães, Ana; et al. "Chitosan microparticles as a binding system against Helicobacter pylori.". Paper presented in 6th Symposium on Bioengineering, 2014. Aroso, Miguel; Gomez-Lazaro, Maria; Rinn, C; Vitorino, Rui; Amado, Francisco; Schrader, Michael. ": Suborganellar proteomics: Getting a grip on pancreatic zymogen granule membrane proteins". Paper presented in 5th ProCura 1stICAP meeting, 2009. Gomez-Lazaro, Maria; Vitorino, Rui; Amado, Francisco; Shcrader, Michael. "The submembanous granule matrix: Getting a grip on proteoglycans from pancreatic zymogen granules". Paper presented in Hands on course in proteins and proteomics, 2008. Gomez-Lazaro, Maria; Rinn, C; Faust, F; Borta, Heike; Vitorino, Rui; Amado, Francisco; Schrader, Michael. "Suborganellar proteomics: Identification and characterization of pancreatic zymogen granule membrane proteins". Paper presented in ProCura-RNEM Meeting. Aveiro, Portugal, 2007. Gomez-Lazaro, Maria; Bonekamp, Nina; Jordan, J; Schrader, Michael. "6-Hydroxydopamine and 3-nitropropionic acid: Two ways towards the same end?". Paper presented in XXIX Congress of the Spanish Society of Biochemistry and Molecular Biology, 2007. Gomez-Lazaro, Maria; Galindo, MF; Fernandez-Gomez, FJ; Garcia-Martinez, E; Jordan, J. "Involvement of Bax redistribution in the celular death induced by 6-OHDA". Paper presented in GEN XXVI. Plentzia (Bizkaia), Spain, 2005. Galindo, MF; Gomez-Lazaro, Maria; Fernandez-Gomez, FJ; Garcia-Martinez, E; Prehn, J.H.M.; Jordan, J. "p53 and its target gene PUMA are induced by veratridien in cromaphine cell cultures". Paper presented in GEN XXVI. Plentzia (Bizkaia), Spain., 2005. Fernandez-Gomez, FJ; Gomez-Lazaro, Maria; Pastor, M; Garcia-Martinez, E; Calvo, S; Aguirre, N; Galindo, MF; Jordan, J. "The antibiotic Minocicline does not protect neuronal cultures against the celular damage induced by malonate". Paper presented in GEN XXVI. Plentzia (Bizkaia), Spain, 2005. Fernandez-Gomez, FJ; Gomez-Lazaro, Maria; Pastor, M; Garcia-Martinez, E; Calvo, S; Aguirre, N; Galindo, MF; Jordan, J. "Malonate action is not inhibited by the antibiotic minocicline in primary cultures of rat cerebellum". Paper presented in VI Congress of the Geriatrics and Gerontology Society of Castilla-La Mancha . Albacete, Spain, 2005. Gomez-Lazaro, Maria; Galindo, MF; Fernandez-Gomez, FJ; Prehn, J.H.M.; Jordan, J. "Involvement of p53 and its target gene PUMA in cellular death processes induced by depolarization.". Paper presented in Severo Ochoa’s Ceremony, 100 years: looking to the future. Spanish Foundation for Science and Technology. Madrid, Spain., 2005. Gomez-Lazaro, Maria; Galindo, MF; Fernandez-Gomez, FJ; Prehn, J.H.M.; Jordan, J. "Activation of P53 and its pro-apoptotic target gene PUMA during depolarization-induced apoptosis of chromaffin cells". Paper presented in 27th Congress of the Spanish Society of Pharmacology. Girona, Spain., 2005. Fernandez-Gomez, FJ; Gomez-Lazaro, Maria; Pastor, M; Calvo, S; Aguirre, N; Galindo, MF; Jordan, J. "Minocycline fails to protect cerebellar granular cell cultures against malonate- induced cell death.". Paper presented in 27th Congress of the Spanish Society of Pharmacology. Girona, Spain, 2005. Fernandez-Gomez, FJ; Gomez-Lazaro, Maria; Pastor, M; Calvo, S; Aguirre, N; Galindo, MF; Jordan, J. "Minocicline does not protect cerebellar granular cells againts malonate induced neurotoxicity.". Paper presented in Congress of the Spanish Society of Neuroscience. Málaga, Spain., 2005. Galindo, MF; Gomez-Lazaro, Maria; Fernandez-Gomez, FJ; Jordan, J. "P53 and its target gene PUMA during apoptosis induced by chromaphin cells depolarization.". Paper presented in Congress of the Spanish Society of Neuroscience. Málaga, Spain., 2005. Fernandez-Gomez, FJ; Gomez-Lazaro, Maria; Pastor, MD; Calvo, S; Aguirre, N; Galindo, MF; Jordan, J. "Minocycline does not Project granular cerebellar cells from malonate-induced neurotoxicity.". Paper presented in Neuromeetings of Castilla-La Mancha. I Meeting of Neurology and Neurobiology Research groups of Castilla La Mancha, 2005. Gomez-Lazaro, Maria; Galindo, MF; Fernandez-Gomez, FJ; Jordan, J. "6-Hidroxidopamine induces cell death through subcellular Bax redistribution in SH-SY5Y cells". Paper presented in Neuromeetings of Castilla-La Mancha. I Meeting of Neurology and Neurobiology Research groups of Castilla La Mancha., 2005. Gomez-Lazaro, Maria; Galindo, MF; Fernandez-Gomez, FJ; Gonzalez-Garcia, C; Cena, V; Jordan, J. "Function and regulation of p53 in neuronal cell death induced by veratridine". Paper presented in 1st Symposium of the Spanish Society of Geriatric Medicine., 2004. Fernandez-Gomez, FJ; Galindo, MF; Gomez-Lazaro, Maria; Gonzalez-Garcia, C; Cena, V; Jordán, J.. "Malonate induces cell death through a mechanism mediated by mitocondrial collpase and reactive oxygen species". Paper presented in 1st Symposium of the Spanish Society of Geriatric Medicine. Valencia, Spain, 2004. Galindo, MF; Fernandez-Gomez, FJ; Gomez-Lazaro, Maria; Gonzalez-Garcia, C; Cena, V; Jordan, J. "Mitochondria as a pharmacological target of the neuroprotective effects of minocicline.". Paper presented in 1st Symposium of the Spanish Society of Geriatric Medicine, 2004.
Journal article	Freitas, Laura; Bezerra, Andrea; Resende-Coelho, Ana; Gomez-Lazaro, Maria; Maciel, Leonardo; Amorim, Tânia; Fernandes, Ricardo J.; Fonseca, Hélder. "Impact of Long-Term Swimming Exercise on Rat Femur Bone Quality". Biomedicines 12 1 (2023): 35. http://dx.doi.org/10.3390/biomedicines12010035. 10.3390/biomedicines12010035 Raquel Pinto; Jan Matula; Maria Gomez-Lazaro; Mafalda Sousa; Andrea Lobo; Tomas Zikmund; Jozef Kaiser; João R. Gomes. "High-resolution micro-CT for 3D infarct characterization and segmentation in mice stroke models". Scientific Reports (2022): http://dx.doi.org/10.1038/s41598-022-21494-9. 10.1038/s41598-022-21494-9 Rodrigues, Pedro M.; Sousa, Laura G.; Perrod, Chiara; Maceiras, Ana R.; Ferreirinha, Pedro; Pombinho, Rita; Romera-Cárdenas, Gema; et al. "LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development". Autophagy 19 2 (2022): 426-439. http://dx.doi.org/10.1080/15548627.2022.2074105. 10.1080/15548627.2022.2074105 João Gomes; Matula, Jan; Raquel Pinto; Maria Mafalda Vieira Pereira Gonçalves de Sousa; Tomas Zikmund; Jozef Kaiser; Gomez-Lazaro, Maria. "High resolution micro-CT imaging in mice stroke models: from 3D detailed infarct characterization to automatic area segmentation". bioRxiv (2022): https://www.biorxiv.org/content/10.1101/2022.02.02.478782v1. Huw Summers; Carla P. Gomes; Aida Varela-Moreira; Ana Spencer; Maria Gomez Lazaro; Ana P. Pêgo; Paul Rees. "Data-Driven Modeling of the Cellular Pharmacokinetics of Degradable Chitosan-Based Nanoparticles". Nanomaterials (2021): https://www.mdpi.com/2079-4991/11/10/2606. 10.3390/nano11102606 Ana Freitas; Aroso, M.; António S. Barros; Miriam Fernández; Eduardo Conde-Sousa; Marina Leite; Eva Daniela Carvalho; et al. "Characterization of the Striatal Extracellular Matrix in a Mouse Model of Parkinson’s Disease". Antioxidants (2021): https://www.mdpi.com/2076-3921/10/7/1095. 10.3390/antiox10071095 Ana Freitas; Miguel Aroso; Sara Rocha; Rita Ferreira; Rui Vitorino; Maria Gomez-Lazaro. "Bioinformatic analysis of the human brain extracellular matrix proteome in neurodegenerative disorders". European Journal of Neuroscience (2021): https://doi.org/10.1111/ejn.15316. 10.1111/ejn.15316 Biselli, Sabrina; Alencastre, Inês; Tropmann, Katharina; Erdmann, Daniela; Chen, Mengya; Littmann, Timo; Maia, André F.; et al. "Fluorescent H2 Receptor Squaramide-Type Antagonists: Synthesis, Characterization, and Applications". ACS Medicinal Chemistry Letters 11 8 (2020): 1521-1528. http://dx.doi.org/10.1021/acsmedchemlett.0c00033. Published • 10.1021/acsmedchemlett.0c00033 Marina Leite; Miguel S. Marques; Joana Melo; Marta T. Pinto; Bruno Cavadas; Miguel Aroso; Gomez-Lazaro, Maria; Raquel Seruca; Ceu Figueiredo. "Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions". Cells (2020): https://doi.org/10.3390/cells9020513. 10.3390/cells9020513 Sousa, Daniela M.; Martins, Pedro S.; Leitão, Luís; Alves, Cecília J.; Gomez-Lazaro, Maria; Neto, Estrela; Conceição, Francisco; Herzog, Herbert; Lamghari, Meriem. "The lack of neuropeptide Y-Y 1 receptor signaling modulates the chemical and mechanical properties of bone matrix". The FASEB Journal 34 3 (2020): 4163-4177. http://dx.doi.org/10.1096/fj.201902796r. Published • 10.1096/fj.201902796r Teixeira, G.Q.; Pereira, C.L.; Ferreira, J.R.; Maia, A.F.; Gomez-Lazaro, Maria; Barbosa, M.A.; Neidlinger-Wilke, C.; Goncalves, R.M.. "Immunomodulation of Human Mesenchymal Stem/Stromal Cells in Intervertebral Disc Degeneration". Spine 43 12 (2018): E673-E682. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048118371&partnerID=MN8TOARS. 10.1097/BRS.0000000000002494 Seabra, C.L.; Nunes, C.; Brás, M.; Gomez-Lazaro, Maria; Reis, C.A.; Gonçalves, I.C.; Reis, S.; Martins, M.C.L.. "Lipid nanoparticles to counteract gastric infection without affecting gut microbiota". European Journal of Pharmaceutics and Biopharmaceutics 127 (2018): 378-386. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044023662&partnerID=MN8TOARS. 10.1016/j.ejpb.2018.02.030 Sara Rocha; Ana Freitas; Sofia Guimaraes; Rui Vitorino; Miguel Aroso; Gomez-Lazaro, Maria. "Biological Implications of Differential Expression of Mitochondrial-Shaping Proteins in Parkinson’s Disease". Antioxidants 7 1 (2017): 1-1. https://doi.org/10.3390/antiox7010001. 10.3390/antiox7010001 Olivera-Severo, D.; Uberti, A.F.; Marques, M.S.; Pinto, M.T.; Gomez-Lazaro, Maria; Figueiredo, C.; Leite, M.; Carlini, C.R.. "A new role for Helicobacter pylori urease: Contributions to angiogenesis". Frontiers in Microbiology 8 SEP (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85030183952&partnerID=MN8TOARS. 10.3389/fmicb.2017.01883 Seabra, C.L.; Nunes, C.; Gomez-Lazaro, Maria; Correia, M.; Machado, J.C.; Gonçalves, I.C.; Reis, C.A.; Reis, S.; Martins, M.C.L.. "Docosahexaenoic acid loaded lipid nanoparticles with bactericidal activity against Helicobacter pylori". International Journal of Pharmaceutics 519 1-2 (2017): 128-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010199517&partnerID=MN8TOARS. 10.1016/j.ijpharm.2017.01.014 Passmore, J.B.; Pinho, S.; Gomez-Lazaro, Maria; Schrader, M.. "The respiratory chain inhibitor rotenone affects peroxisomal dynamics via its microtubule-destabilising activity". Histochemistry and Cell Biology 148 3 (2017): 331-341. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019595090&partnerID=MN8TOARS. 10.1007/s00418-017-1577-1 Castro, F.; Pinto, M.L.; Silva, A.M.; Pereira, C.L.; Teixeira, G.Q.; Gomez-Lazaro, Maria; Santos, S.G.; et al. "Pro-inflammatory chitosan/poly(¿-glutamic acid) nanoparticles modulate human antigen-presenting cells phenotype and revert their pro-invasive capacity". Acta Biomaterialia 63 (2017): 96-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030032238&partnerID=MN8TOARS. 10.1016/j.actbio.2017.09.016 Lao-Peregrín, C.; Ballesteros, J.J.; Fernández, M.; Zamora-Moratalla, A.; Saavedra, A.; Gomez-Lazaro, Maria; Pérez-Navarro, E.; Burks, D.; Martín, E.D.. "Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling". Addiction Biology 22 6 (2017): 1706-1718. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979236361&partnerID=MN8TOARS. 10.1111/adb.12433 Gomes, C.P.; Varela-Moreira, A.; Leiro, V.; Lopes, C.D.F.; Moreno, P.M.D.; Gomez-Lazaro, Maria; Pêgo, A.P.. "A high-throughput bioimaging study to assess the impact of chitosan-based nanoparticle degradation on DNA delivery performance". Acta Biomaterialia 46 (2016): 129-140. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992170399&partnerID=MN8TOARS. 10.1016/j.actbio.2016.09.037 Teixeira, G.Q.; Leite Pereira, C.; Castro, F.; Ferreira, J.R.; Gomez-Lazaro, Maria; Aguiar, P.; Barbosa, M.A.; Neidlinger-Wilke, C.; Goncalves, R.M.. "Anti-inflammatory Chitosan/Poly-¿-glutamic acid nanoparticles control inflammation while remodeling extracellular matrix in degenerated intervertebral disc". Acta Biomaterialia 42 (2016): 168-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983262266&partnerID=MN8TOARS. 10.1016/j.actbio.2016.06.013 Ribeiro, N.; Costa-Pinheiro, P.; Henrique, R.; Gomez-Lazaro, Maria; Pereira, M.P.; Mansur, A.A.P.; Mansur, H.S.; et al. "Comprehensive analysis of secreted protein, acidic and rich in cysteine in prostate carcinogenesis: Development of a 3d nanostructured bone-like model". Journal of Biomedical Nanotechnology 12 8 (2016): 1667-1678. http://www.scopus.com/inward/record.url?eid=2-s2.0-84986593214&partnerID=MN8TOARS. 10.1166/jbn.2016.2276 Marques, O.; Porto, G.; Rêma, A.; Faria, F.; Cruz Paula, A.; Gomez-Lazaro, Maria; Silva, P.; Martins da Silva, B.; Lopes, C.. "Local iron homeostasis in the breast ductal carcinoma microenvironment". BMC Cancer 16 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84959276692&partnerID=MN8TOARS. Published • 10.1186/s12885-016-2228-y Aroso, Miguel; Ferreira, R.; Vitorino, Rui; Gomez-Lazaro, Maria. "New insights on the mitochondrial proteome plasticity in Parkinson's disease". Proteomics - Clinical Applications 10 4 (2016): 416-429. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959422268&partnerID=MN8TOARS. Published • 10.1002/prca.201500092 Caires, H.R.; Gomez-Lazaro, Maria; Oliveira, C.M.; Gomes, D.; Mateus, D.D.; Oliveira, C.; Barrias, C.C.; Barbosa, M.A.; Almeida, C.R.. "Finding and tracing human MSC in 3D microenvironments with the photoconvertible protein Dendra2". Scientific Reports 5 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84929376876&partnerID=MN8TOARS. 10.1038/srep10079 Lopes, Cátia DF; Gomez-Lazaro, Maria; Pêgo, Ana Paula. "Seeing is believing but quantifying is deciding". Nanomedicine 10 15 (2015): 2307-2310. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940553745&partnerID=MN8TOARS. Published • 10.2217/nnm.15.101 Costa-Almeida, R.; Gomez-Lazaro, Maria; Ramalho, C.; Granja, P.L.; Soares, R.; Guerreiro, S.G.. "Fibroblast-endothelial partners for vascularization strategies in tissue engineering". Tissue Engineering - Part A 21 5-6 (2015): 1055-1065. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924404743&partnerID=MN8TOARS. Published • 10.1089/ten.tea.2014.0443 Silva, A.M.; Varela-Moreira, A.; Gomes, C.P.; Molinos, M.; Leite, M.; Almeida, M.; Ribeiro, D.; et al. "Integrated Analysis of Biological Samples by Imaging Flow Cytometry". Microscopy and Microanalysis 21 (2015): 95-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944073933&partnerID=MN8TOARS. 10.1017/S1431927615014282 Nunes, J.B.; Peixoto, J.; Soares, P.; Maximo, V.; Carvalho, S.; Pinho, S.S.; Vieira, A.F.; et al. "OXPHOS dysfunction regulates integrin-ß1 modifications and enhances cell motility and migration". Human Molecular Genetics 24 7 (2014): 1977-1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926488610&partnerID=MN8TOARS. Published • 10.1093/hmg/ddu612 Bonekamp, N.A.; Islinger, M.; Lázaro, M.G.; Schrader, M.. "Cytochemical detection of peroxisomes and mitochondria.". Methods in molecular biology (Clifton, N.J.) 931 (2013): 467-482. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873493575&partnerID=MN8TOARS. Borta, H.; Aroso, Miguel; Rinn, C.; Gomez-Lazaro, Maria; Vitorino, R.; Zeuschner, D.; Grabenbauer, M.; Amado, F.; Schrader, M.. "Analysis of low abundance membrane-associated proteins from rat pancreatic zymogen granules". Journal of Proteome Research 9 10 (2010): 4927-4939. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957346850&partnerID=MN8TOARS. Published • 10.1021/pr100052q Gomez-Lazaro, Maria; Rinn, C.; Aroso, Miguel; Amado, Francisco; Schrader, M.. "Proteomic analysis of zymogen granules". Expert Review of Proteomics 7 5 (2010): 735-747. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958539996&partnerID=MN8TOARS. Published • 10.1586/epr.10.31 Faust, F.; Gomez-Lazaro, Maria; Borta, H.; Agricola, B.; Schrader, M.. "Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells". Traffic 9 6 (2008): 964-979. http://www.scopus.com/inward/record.url?eid=2-s2.0-43149088924&partnerID=MN8TOARS. Published • 10.1111/j.1600-0854.2008.00739.x Gomez-Lazaro, Maria; Bonekamp, N.A.; Galindo, M.F.; Jordán, J.; Schrader, M.. "6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells". Free Radical Biology and Medicine 44 11 (2008): 1960-1969. http://www.scopus.com/inward/record.url?eid=2-s2.0-43149115834&partnerID=MN8TOARS. Published • 10.1016/j.freeradbiomed.2008.03.009 Gomez-Lazaro, Maria; Galindo, M.F.; Concannon, C.G.; Segura, M.F.; Fernandez-Gomez, F.J.; Llecha, N.; Comella, J.X.; Prehn, J.H.M.; Jordan, J.. "6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA". Journal of Neurochemistry 104 6 (2008): 1599-1612. http://www.scopus.com/inward/record.url?eid=2-s2.0-39849090617&partnerID=MN8TOARS. Published • 10.1111/j.1471-4159.2007.05115.x Gomez-Lazaro, Maria; Galindo, M.F.; Melero-Fernandez De Mera, R.M.; Fernandez-Gómez, F.J.; Concannon, C.G.; Segura, M.F.; Comella, J.X.; Prehn, J.H.M.; Jordan, J.. "Reactive oxygen species and p38 mitogen-activated protein kinase activate bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate". Molecular Pharmacology 71 3 (2007): 736-743. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847109840&partnerID=MN8TOARS. Published • 10.1124/mol.106.030718 Fernandez-Gomez, F.J.; Pastor, M.D.; Garcia-Martinez, E.M.; Melero-Fernandez de Mera, R.; Gou-Fabregas, M.; Gomez-Lazaro, Maria; Calvo, S.; et al. "Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression". Neurobiology of Disease 24 2 (2006): 296-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750201619&partnerID=MN8TOARS. Published • 10.1016/j.nbd.2006.07.005 Gomez-Lazaro, Maria; Galindo, M.F.; Fernandez-Gomez, F.J.; Prehn, J.H.M.; Jordán, J.. "Activation of p53 and the pro-apoptotic p53 target gene PUMA during depolarization-induced apoptosis of chromaffin cells". Experimental Neurology 196 1 (2005): 96-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-26244466049&partnerID=MN8TOARS. Published • 10.1016/j.expneurol.2005.07.011 Fernandez-Gomez, F.J.; Galindo, M.F.; Gomez-Lazaro, Maria; Yuste, V.J.; Comella, J.X.; Aguirre, N.; Jordán, J.. "Malonate induces cell death via mitochondrial potential collapse and delayed swelling through an ROS-dependent pathway". British Journal of Pharmacology 144 4 (2005): 528-537. http://www.scopus.com/inward/record.url?eid=2-s2.0-14844310360&partnerID=MN8TOARS. Published • 10.1038/sj.bjp.0706069 Fernandez-Gomez, F.J.; Gomez-Lazaro, Maria; Pastor, D.; Calvo, S.; Aguirre, N.; Galindo, M.F.; Jordán, J.. "Minocycline fails to protect cerebellar granular cell cultures against malonate-induced cell death". Neurobiology of Disease 20 2 (2005): 384-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-26944464584&partnerID=MN8TOARS. Published • 10.1016/j.nbd.2005.03.019 Fernandez-Gomez, F.J.; Galindo, M.F.; Gomez-Lazaro, Maria; González-García, C.; C¿na, V.; Aguirre, N.; Jordán, J.. "Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions". Neuroscience 133 4 (2005): 959-967. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444483258&partnerID=MN8TOARS. Published • 10.1016/j.neuroscience.2005.03.019 Gomez-Lazaro, Maria; Galindo, MF; Fernandez-Gomez, FJ; Jordan, J. "Pharmacological involvement of the mitochondria in the molecular and cellular pathways related to Parkinson’s disease". Actualidad Farmacológica y Terapéutica. 3 3 (2005): 221-223. Accepted Gomez-Lazaro, Maria; Fernández-Gómez, F.J.; Jordán, J.. "The role of protein p53 in neurodegenerative processes throughout the 25 years of its history,La proteína p53 en procesos neurodegenerativos en sus 25 años de historia". Revista de Neurologia 39 3 (2004): 243-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-4744372189&partnerID=MN8TOARS. Published Gomez-Lazaro, Maria; Fernandez-Gomez, F.J.; Jordán, J.. "p53: Twenty five years understanding the mechanism of genome protection". Journal of Physiology and Biochemistry 60 4 (2004): 287-308. http://www.scopus.com/inward/record.url?eid=2-s2.0-20144376909&partnerID=MN8TOARS. Published Fernandez-Gomez, FJ; Gomez-Lazaro, Maria; Jordan, J. "Our guardian p53 celebrates its Silver wedding". Actualidad Farmacológica y Terapéutica 2 3 (2004): 243-250. Published
Preprint	Raquel Pinto; Jan Matula; Maria Gomez-Lazaro; Mafalda Sousa; Tomas Zikmund; Jozef Kaiser; João R. Gomes. "High resolution micro-CT imaging in mice stroke models: from 3D detailed infarct characterization to automatic area segmentation". 2022. https://doi.org/10.1101/2022.02.02.478782. 10.1101/2022.02.02.478782

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2009/09/30	Suborganellar proteomics: Getting a grip on pancreatic zymogen granule membrane proteins.	5th ProCura 1stICAP meeting. (Caparica, Portugal)
2009	Suborganellar proteomics: Getting a grip on pancreatic zymogen granule membrane proteins	5th ProCura 1stICAP meeting (Caparica, Portugal)
2006/09/07	Reactive oxygen species mediate Bax redistribution during malonate cytotoxicity.	XXIX Congress of the Spanish Society of Biochemistry and Molecular Biology. (Elche, Spain)
2005/11/25	Veratridine induces cell death through p53 and PUMA proteins activation.	VI Congress of the Geriatrics and Gerontology Society of Castilla-La Mancha. Universidad de Castilla-La Mancha (albacete, Spain)
2005/11/25	6-OHDA induces cell death in SH-SY5Y cells through Bax redistribution.	VI Congress of the Geriatrics and Gerontology Society of Castilla-La Mancha. Universidad de Castilla-La Mancha (Albacete, Spain)
2005/09/15	6-OHDA induces cell death in SH-SY5Y cells through Bax redistribution.	Spanish Neuroscience Society Congress. (Málaga, Spain)
2005/02/08	Caspase-9 and p53, special guests to the cellular death induce by veratridine	II Congress of the Young researchers of The Health Campus of Albacete Universidad de Castilla-La Mancha -Facultad de Medicina (Albacete, Spain)
2005	6-OHDA induces cytochrome c release but not mitochondrial swelling.	VII Apomeeting (Miraflores de la Sierra, Spain)
2004/09/26	Role and regulation of p53 in depolarization-induced neuronal death.	XXVI Congress of the Spanish Society of Pharmacology. Universidad de Salamanca (Salamanca, Spain)
2004/09/22	Mitochondrial collapse and the reactive oxygen species participate in the cellular death induced by malonate.	III Oncologic Symposium CIC. I ASEICA thematic meeting. Centro de investigación del Cancer (CIC)- Salamanca (Salamanca, Spain)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2014 - Current	The Extracellular ‘memories’ in Parkinson’s disease Supervisor of Ana Maria Salgueiro Freitas	PhD in neuroscience (PhD) Universidade do Porto Faculdade de Medicina, Portugal
2015 - 2021	The extracellular "memories" in Parkinson's disease Supervisor	Neurociências (PhD) Universidade do Porto Faculdade de Medicina, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2006 - Current	Organization of the 3rd Young Researchers Congress at the Faculty of Medicine (2006) Congress (Member of the Organising Committee)	Universidad de Castilla-La Mancha Facultad de Medicina, Spain
2022/09/26 - 2022/09/28	ASTROTECH Training School (2022/09/26 - 2022/09/28) Workshop (Member of the Organising Committee)	i3s - Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação, Portugal
2022/05/23 - 2022/05/27	High Throughput Screening and Image Analysis for BioSciences (2022/05/23 - 2022/05/27) Workshop (Co-organisor)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/05/25 - 2021/05/28	High Content Screening generates a massive amount of image-based data in the biosciences field. Images contain diverse and valuable quantifiable data, however, many researchers lack the knowledge to extract those data in a practical, fast and repetitive way. Fundamentally practical, in this modular course, participants will get acquainted with several open-source image analysis software (ImageJ/Fiji, ilastik, CellProfiler, CellProfiler Analyst, IDEAS® and Cytosplore) designed to deal with large amounts of images. Experimental data will be used as da (2021/05/25 - 2021/05/28) Workshop (Co-organisor)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal INEB - Instituto Nacional de Engenharia Biomédica, Portugal
2019/05/27 - 2019/05/31	High Throughput Screening (HTS) and Image Analysis for Biosciences . Fundamentally practical, the second edition of the course on High Throughput Screening (HTS) and Image Analysis for Biosciences, aims introducing the participants in experimental design, image acquisition, image and data analysis for high throughput (HT) experiments (2019/05/27 - 2019/05/31) Workshop (Co-organisor)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/06/18 - 2018/06/22	High Throughput Screening (HTS) and Image Analysis for Biosciences. Introducing the participants in experimental design, image acquisition, image and data analysis for high throughput (HT) experiments. These are essential skills when generating massive amount of imaged-based data in the biosciences field. (2018/06/18 - 2018/06/22) Workshop	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/06/06 - 2017/06/08	Hands-on workshop on Image Analysis for Imaging flow Cytometry. This hands-on course is divided in two main parts covering from the use of the imaging flow cytometer (Imagestream) and basic image analysis to advanced image analysis focusing on machine learning for Imagestream data using the Cell Profiler environment and batch analysis with ImageJ amongst others. (2017/06/06 - 2017/06/08) Workshop (Co-organisor)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/10/26 - 2016/10/28	BIOIMAGING 2016. 5th INTERNATIONAL SYMPOSIUM IN APPLIED BIOIMAGING: DISEASE IN FOCUS. This year the Symposium, designed as a forum for those interested in the application of bioimaging tools for life and medical sciences. (2016/10/26 - 2016/10/28) Symposium (Member of the Organising Committee)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/09/28 - 2016/09/30	Hands on workshop on Image Analysis for Imaging Flow Cytometry. Essentially practical, this course aims at introducing the students in the use of the imaging flow cytometer and image data analysis. (2016/09/28 - 2016/09/30) Workshop (Co-organisor)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/04/11 - 2016/04/15	AFM BioMEd Conference. This conferenc is dedicated to life sciences and nanomedicine applications and will investigate how Atomic Force Microscopy (AFM) solves relevant biological bottlenecks and provides innovative solutions for healthcare. The conferences link international academica and industrial experts in life science, being involved either with AFM use or with medical/biological studies. Te meetings provide a clear comprehensive overview on advances in this field through keynote presentations, lectures, poster sessions and discussion forums. (2016/04/11 - 2016/04/15) Conference (Member of the Organising Committee)	Instituto Nacional de Engenharia Biomédica, Portugal
2015/11/04 - 2015/11/06	Bioimaging2015. International symposium in applied bioimaging. The pre-clinical challenge in 3D. The symposium was designed as a forum for those interested in the application of bioimaging tools for life and medical sciences, covering aspects ranging from imaging modalities to analysis and simulation. (2015/11/04 - 2015/11/06) Symposium (Member of the Organising Committee)	Instituto Nacional de Engenharia Biomédica, Portugal
2014/10/14 - 2014/10/16	Bioimaging2014. International symposium in applied bioimaging. Capturing Life in a pixel. The Symposium was designed for those who have an interest in the application of bioimaging, from the fields of Bioimaging applied to Biomaterials and Regeneration through integrative approaches from molecular to biomedical imaging. (2014/10/14 - 2014/10/16) Symposium (Member of the Organising Committee)	Instituto Nacional de Engenharia Biomédica, Portugal
2014/04/14 - 2014/04/16	Working with ImageJ and Icy: Hands on image analysis for microscopy. This hands-on workshop was directed to users working on biology and biomedicine that require objective analysis of microscopy image data. ImageJ, its distribution Fiji and ICY are widely-used public-domain software for microscopy image analysis. ImageJ/FIJI are based on an open source architecture, which enables functionality extensibility using plugins and Macros. ICY is an open source software that is compatible with ImageJ plugins but which enables other functionalities. (2014/04/14 - 2014/04/16) Workshop	Instituto Nacional de Engenharia Biomédica, Portugal
2013/10/03 - 2013/10/04	Bioimaging2013. International symposium in applied bioimaging. From molecule to man. This Symposium was designed for those who have an interest in the application of bioimaging, especially in the field of biomaterials, tissue engineering and regenerative medicine. (2013/10/03 - 2013/10/04) Symposium (Member of the Organising Committee)	Instituto Nacional de Engenharia Biomédica, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2023/10/12	Using optogenetics to understand how tissues restore epithelial organization (Thesis) Main arguer	Hugo Couto Moreira (Master) i3s - Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação, Portugal
2023/07	Assessing reactive astrogliosis in Parkinson’s brain with astroglial tracers BU99008 and Deprenyl (Thesis) Main arguer	Filipa Monteiro Neves Rocha (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022	Dissecting Pink1 mRNA transport and translation associated to neuronal mitochondria (Thesis) Main arguer	Mariana Braga Moreira de Sousa Martins (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022	Investigation of encapsulins as multimodular imaging tools (Thesis) Main arguer	Filipa Roque Gonçalves (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/07	Advanced techniques in bioimage analysis for the study of neurodegenerative diseases – reconstruction and morphometric analysis of dendritic spines (Thesis) Main arguer	Gustavo Caetano (Master) Universidade do Porto Faculdade de Engenharia, Portugal
2014/12/17	Exploring the role of peroxisomes in Helicobacter pylori infection (Thesis) Main arguer	Sandra Manuela Carvalho Alves (Master) Universidade de Aveiro - Secção Autónoma de Ciências da Saúde, Portugal
2014	Exploring the role of peroxisomes in Helicobacter pylori infection (Thesis) Main arguer	Sandra Manuela Carvalho Alves (Master) Universidade de Aveiro Instituto de Biomedicina, Portugal
2013/10/10	Labeling of HMSCS (Thesis) Main arguer	Diogo Reis santos (Master) Universidade do Porto Faculdade de Engenharia, Portugal
2013	Knocking-down LAP1 using the short hairpin RNA strategy (Thesis) Main arguer	Patricia Costa (Master) Universidade de Aveiro Instituto de Biomedicina, Portugal
2013	Characterization of the mitochondrial dynamic processes in experimental neurodegenerative disease models (Thesis) Main arguer	María de la Encarnación Solesio Torregrosa (PhD) Universidad de Castilla-La Mancha - Facultad de Medicina, Spain
2012	APP phosphorylation on PPA/G¿0 colocalization and STAT3 activation (Thesis) Main arguer	Roberto Alexandre dos Santos (Master) Universidade de Aveiro, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2022/05/25 - Current	Image analysis for the Imaging flow cytometry	High Throughput Screening and Image Analysis for BioSciences (Curso de Especialização Tecnológica)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/05/23 - Current	Imaging in Flow	High Throughput Screening and Image Analysis for BioSciences (Curso de Especialização Tecnológica)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/04/14 - 2023/04/14	Imaging Flow Cytometry	Cell functional and phenotypical analysis: The usefulness of flow cytometry and related tools	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/03/20 - 2023/03/20	Sample preparation for microscopy	Course on Optical Microscopy Imaging for Biosciences \| 14th edition (Postgraduate Certificate)	i3s - Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação, Portugal
2022/09/27 - 2022/09/27	Imaging Across Scales. Challenges in imaging 3D models	ASTROTECH TRAINING SCHOOL (Pós-Graduação)	i3s - Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação, Portugal
2022/09/27 - 2022/09/27	Imaging Processing and Analysis	ASTROTECH TRAINING SCHOOL (Pós-Graduação)	i3s - Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação, Portugal
2022/09/26 - 2022/09/26	Laboratory session ImageStream	ASTROTECH TRAINING SCHOOL (Pós-Graduação)	i3s - Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação, Portugal
2021/05/25 - 2021/05/28	Several sessions within the: High Throughput Screening (HTS) and Image Analysis for Biosciences	(Curso de Especialização Tecnológica)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal INEB - Instituto Nacional de Engenharia Biomédica, Portugal
2019/05/27 - 2019/05/31	Several sessions within the: High Throughput Screening (HTS) and Image Analysis for Biosciences	(Curso de Especialização Tecnológica)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/06/18 - 2018/06/22	Several sessions within the hands on workshop: High Throughput Screening (HTS) and Image Analysis for Biosciences	(Curso de Especialização Tecnológica)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/06/07 - 2017/06/09	Hands on workshop on Image Analysis for Imaging Flow Cytometry	(Curso de Especialização Tecnológica)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/09/28 - 2016/09/30	Hands on workshop on Image Analysis for Imaging Flow Cytometry	(Curso de Especialização Tecnológica)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/11/04 - 2015/11/04	Labsession from the International symposium in applied bioimaging. Bioimaging2015: Perfusion cultures and Impedance measurements.	Perfusion cultures and Impedance measurements. (Outros)	Instituto Nacional de Engenharia Biomédica, Portugal
2015/07/03 - 2015/07/03	Labsession from the Advanced Summer school. Interrogations at the biointerface: Assessment of anti-inflammatory nanoparticles internalization in a pro-inflammatory/ degenerative bovine intervertebral disc organ culture	Assessment of anti-inflammatory nanoparticles internalization in a pro-inflammatory/ degenerative bovine intervertebral disc organ culture	Instituto Nacional de Engenharia Biomédica, Portugal
2014/10/15 - 2014/10/15	Labsession from the International symposium in applied bioimaging. Bioimaging2014: Imaging flow cytometry, looking beyond the flow.	Imaging flow cytometry, looking beyond the flow.	Instituto Nacional de Engenharia Biomédica, Portugal
2013/10/02 - 2013/10/02	Imaging Flow Cytometry for Quantification of Cellular Parameters. Part of the Bioimaging2013. International symposium in applied bioimaging. From molecule to man	Imaging Flow Cytometry for Quantification of Cellular Parameters. (Outros)	Instituto Nacional de Engenharia Biomédica, Portugal
2013/03 - 2013/03	Imaging Flow Cytometry Master course: Experimental Biomedicine	Master course: Experimental Biomedicine (Mestrado)	Universidad de Castilla-La Mancha - Facultad de Medicina, Spain
2013/03 - 2013/03	Bioimaging Centre for Biomaterials and Regenerative Therapies (b.IMAGE). Confocal Microscopy, imaging flow cytometry and Confocal Raman. Lecture in the GABBA PhD program: "New Therapies and Technologies".	GABBA PhD program: "New Therapies and Technologies". (Curso de doutoramento (conclusão de unidades curriculares))	Universidade do Porto, Portugal
2013/02 - 2013/02	"Microscopy: Confocal Microscopy and Imaging Flow Cytometry" Lecture in the IB2 PhD course: "Introduction to cell culture techniques for Regenerative Therapies".	IB2 PhD course: "Introduction to cell culture techniques for Regenerative Therapies". (Curso de doutoramento (conclusão de unidades curriculares))	Universidade do Porto, Portugal
2012/03 - 2012/03	Culture of cell lines. Transfections. Cell viability. Master course: Experimental Biomedicine	Master course: Experimental Biomedicine (Mestrado)	Universidad de Castilla-La Mancha - Facultad de Medicina, Spain
2011/05 - 2011/05	Culture of cell lines. Transfections. Cell viability. Master course: Experimental Biomedicine	Master course: Experimental Biomedicine	Universidad de Castilla-La Mancha - Facultad de Medicina, Spain
2011 - 2011	Microscopy an ultrastructure. Master in Biotechnology.	Master in Biotechnology (Mestrado)	Universidade de Aveiro, Portugal
2010/05 - 2010/05	Basic concepts in Flow cytometry Basic use of the Flow cytometer. Flow cytometry in the study of Free Radicals. Flow cytometry in the study of Phagocytosis PhD and master course: Experimental Biomedicine	PhD and master course: Experimental Biomedicine (Curso de doutoramento (conclusão de unidades curriculares))	Universidad de Castilla-La Mancha - Facultad de Medicina, Spain
2010 - 2010	Fundamentals of Confocal microscopy. FRAP. Master: Biomolecular Medicine. Introduction to confocal microscopy and FRAP assay of two GFP-tag membrane proteins with different mobility inside the membrane.	Master: Biomolecular Medicine. (Mestrado)	Universidade de Aveiro - Centro de Biologia Celular, Portugal
2009/06 - 2009/06	Flow cytometry in the study of Free Radicals. PhD course: Experimental Biomedicine	PhD course: Experimental Biomedicine (Curso de doutoramento (conclusão de unidades curriculares))	Universidad de Castilla-La Mancha - Facultad de Medicina, Spain
2009/04 - 2009/04	Fluorescence Microscopy. In Methods of Analysis subject. Clinical Analysis and Public Health degree	Methods of Analysis subject. Clinical Analysis and Public Health degree (Licenciatura)	Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2009 - 2009	Fundamentals of Confocal microscopy. FRAP. Introduction to confocal microscopy and FRAP assay of two GFP-tag membrane proteins with different mobility inside the membrane.	Fundamentals of Confocal microscopy. FRAP. Master: Biomolecular Medicine (Mestrado)	Universidade de Aveiro - Centro de Biologia Celular, Portugal
2008/10 - 2008/10	Neurobiology. Master in Molecular and Cellular Biology. Immunofluorescence protocols with labeling of different organelles inside the mammalian cell and observation under a fluorescence microscope.	Neurobiology (Mestrado)	Universidade de Aveiro - Centro de Biologia Celular, Portugal
2008/10 - 2008/10	Biomolecular methods III. Introduction to SDS-PAGE and visualization of the separated protein bands by Coomassie blue staining.	Master in Biomolecular Methods. Biomolecular methods III. (Mestrado)	Universidade de Aveiro, Portugal
2005/04 - 2005/04	Cellular defence mechanisms against Free radicals and reactive species”. PhD course: “Oxidative stress, implication disease state”.	(Curso de doutoramento (conclusão de unidades curriculares))	Universidad Autónoma de Madrid Facultad de Medicina, Spain

Other jury / evaluation

	Activity description	Institution / Organization
2014/01 - Current	External referee for the evaluation of the fulfillments of the quality standards of the PhD thesis: Real-time visualization of phosphatidic acid in live cells using novel sensors based on FRET. José Pedro Ferraz Nogueira. PhD in Experimental Biomedicine. Faculty of Medicine. Universidad de Castilla-La Mancha, Albacete. Spain	Universidad de Castilla-La Mancha - Facultad de Medicina, Spain
2013 - 2013	External referee for the evaluation of the fulfillments of the quality standards of the PhD thesis: “Characterization of the mitochondrial dynamic processes in experimental neurodegenerative disease models“,María de la Encarnación Solesio Torregrosa, for its PhD defense in the University of Castilla-La Mancha.	Universidad de Castilla-La Mancha - Facultad de Medicina, Spain
2013 - 2013	External referee for the evaluation of the fulfillments of the quality standards of the master thesis: “Labeling of HMSCS“, Diogo Santos, for its master defense in the University of Porto	Universidade do Porto Faculdade de Engenharia, Portugal
2010 - 2010	External referee for the evaluation of the fulfillments of the quality standards of the PhD thesis: “Role of E1a in the ERK pathway. Involvement in the senescence associated to the oncogene v-H-Ras. “,Juan Luis Callejas Valera, for its PhD defense in the University of Castilla-La Mancha	Universidad de Castilla-La Mancha - Facultad de Medicina, Spain
2010 - 2010	External referee for the evaluation of the fulfillments of the quality standards of the PhD thesis: “Study of the molecular and cellular mechanisms involved in the cytotoxic effects induced by methadone and lactacistin“, Sergio Pérez Álvarez, for its PhD defense in the University of Castilla-La Mancha	Universidad de Castilla-La Mancha - Facultad de Medicina, Spain
2010 - 2010	External referee for the evaluation of the fulfillments of the quality standards of the PhD thesis: “Involvement of PKCe in the activation of astrocytes“, Miguel Burgos Lozano, for its PhD defense in the University of Castilla-La Mancha	Universidad de Castilla-La Mancha - Facultad de Medicina, Spain

Distinctions

Award

2008	Award from the HEFAME foundation to the best PhD thesis of 2007. Murcia, Spain. “Molecular and cellular mechanisms involved in the modulation of the mitochondrial membranes permeability in different models of Neurological diseases” Fundación HEFAME, Spain
2007	Award of the Santa María de España Pharmacy Academy of Murcia. Murcia, Spain. “Molecular and cellular mechanisms involved in the modulation of the mitochondrial membranes permeabilization in Parkinson’s disease”. Santa María de España Pharmacy Academy of Murcia., Spain
2007	Award to the best Poster in proteomics in the ProCura-RNEM Meeting. Aveiro, Portugal. “Suborganellar proteomics: Identification and characterization of pancreatic zymogen granule membrane proteins”
2005	Award for the attendance to the XVII Congress of the Spanish Society of Medical Education
2005	Award for the attendance to the Spanish Neuroscience Society Congress
2005	Award for the best oral communication in the VI Congress of the Geriatrics and Gerontology Society of Castilla-La Mancha. “6-OHDA induces cell death in SH-SY5Y cells via bax redistribution”