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Diana O. Silva. 29 years old young researcher in Structural Biology with a strong passion for Science and specifically the Drug Discovery area. Master in Biochemistry for Health (Universidade Nova de Lisboa - Instituto de Tecnologia Química e Biológica (ITQB-NOVA)) and Bachelor Degree in Biochemistry (Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia (FCT-NOVA)). Researcher and PhD student in the Structural Biology for Drug Discovery Unit (SBDD) at Instituto de Biologia Experimental e Tecnológica (iBET) since February 2017.
Identification

Personal identification

Full name
Diana Oliveira da Silva
Date of birth
1993/12/16
Gender
Female

Citation names

  • Diana O. Silva

Author identifiers

Ciência ID
6C1F-2000-B971
ORCID iD
0000-0002-3225-4756
Researcher Id
B-3732-2018

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Chemical Sciences
  • Natural sciences - Biological Sciences - Biophysics
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2014/09 - 2016/11
Concluded
Biochemistry for Health (Mestrado)
Major in Bioquimica; Saude
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents" (THESIS/DISSERTATION)
17
2011/09 - 2014/07
Concluded
Biochemistry (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Projecto Investigação : Utilização de nanopartículas de ouro na resolução da estrutura 3D de macromoléculas biológicas" (THESIS/DISSERTATION)
14
Affiliation

Others

Category
Host institution
Employer
2017/02/01 - Current Bolseiro de investigação - PhD Student Instituto de Biologia Experimental e Tecnológica, Portugal
Structural Biology for Drug Design (SBDD) Unit in iBET , Portugal
2017/06/05 - 2017/06/09 Estagio internacional na empresa Proteros com enfase em fragment screening, structure-based Drug Design e lead discovery. Proteros Biostructures GmbH, Germany
2016/11/01 - 2017/01/31 Bi - Bolseiro de Investigação Instituto de Biologia Experimental e Tecnológica, Portugal
Projects

Grant

Designation Funders
2017/02/01 - Current Target2cypd New opportunities to explore Cyclophilin D as an effective therapeutic drug target
Target2cypd
Master Student Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal
Ongoing
Outputs

Publications

Conference poster
  1. Diana O. Silva; Pedro M. Matias; Rita Ventura; Tiago M. Bandeiras; Ulrich Graedler. "Targeting human Cyclophilin D using Fragment-based Drug Discovery". Paper presented in 9th ITQB NOVA PhD student´s meeting, 2018.
  2. Diana O. Silva; Pedro M. Matias; Rita Ventura; Tiago M. Bandeiras; Ulrich Graedler. "Targeting human Cyclophilin D using Fragment-based Drug Discovery". Paper presented in eCheminfo Oxford 2018 - Training and Innovation Course in Drug Design, 2018.
  3. Diana O. Silva; Micael Freitas; Pedro M. Matias; Rita Ventura; Tiago M. Bandeiras; Ulrich Graedler. "Exploring Cyclophilin D as an effective therapeutic drug target". Paper presented in 7th Nacional Meeting of Portuguese Users of Synchrotron Radiation (ENURS2018), 2018.
  4. Diana O. Silva; Micael Freitas; Pedro M. Matias; Rita Ventura; Tiago M. Bandeiras; Ulrich Graedler. "New opportunities to explore Cyclophilin D as an effective therapeutic drug target". Paper presented in Instruct/CIISB course on fragment screening using crystallography laboratory equipment - Centre of Molecular Structure (CMS), Institute of Biotechnology CAS v.v.i., BIOCEV, 2018.
Journal article
  1. Ana C. F. Paiva; Ana R. Lemos; Philipp Busse; Madalena T. Martins; Diana O. Silva; Micael C. Freitas; Sandra P. Santos; et al. "Extract2Chip—Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance". Biosensors (2023): https://doi.org/10.3390/bios13100913.
    10.3390/bios13100913
Thesis / Dissertation
  1. Silva, Diana. "Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents". Master, Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, 2016. http://hdl.handle.net/10362/65531.
  2. Silva, Diana. "Utilização de nanoparticulas de Ouro na resolução da estrutura 3D de macromoleculas biológicas". Degree, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2014.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/04/23 New approaches used in fragment screening for drug discovery Macromolecular Crystallography Unit
(Oeiras, Lisboa, Portugal)
2017/05/15 New opportunities to explore Cyclophilin D as an effective therapeutic drug target
ITQB-NOVA (Oeiras, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2018/05/15 - 2018/11/17 8th ITQB NOVA PhD student´s meeting (2018/11/15 - 2018/11/17)
Meeting (Member of the Organising Committee)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2019/05/26 - 2019/05/31 INTERNATIONAL SCHOOL ON BIOLOGICAL CRYSTALLIZATION - ISBC2019 provides five days of lectures and practical demonstrations related to the crystallization of biological macromolecules, biominerals and biomimetic materials, with one full day devoted to case studies on the crystallization of membrane proteins, viruses and large macromolecular complexes.
Workshop
ISBC2019
INTERNATIONAL SCHOOL ON BIOLOGICAL CRYSTALLIZATION - ISBC 2019, Spain
2019/01/27 - 2019/01/27 Remote X-ray Data Collection Experiment using synchrotron radiation using Diamond Light Source facility in Oxford
Other
Remote X-ray Data Collection Experiment using synchrotron radiation using Diamond Light Source facility in Oxford
Diamond Light Source Ltd, United Kingdom
2018/11/07 - 2018/11/09 9th ITQB NOVA PhD student´s meeting. Included: Poster Session. Oeiras, Portugal
Meeting
9th ITQB NOVA PhD student´s meeting
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/09/03 - 2018/09/07 eCheminfo Oxford 2018 - Training and Innovation Course in Drug Design. Emerging modeling approaches and tools for all aspects of rational drug design Included: Poster Session. Harwell Science and Innovation Campus, Oxfordshire, England
Workshop
eCheminfo Oxford 2018 - Training and Innovation Course in Drug Design
Diamond Light Source Ltd, United Kingdom
2018/07/23 - 2018/07/23 Remote X-ray Data Collection Experiment using synchrotron radiation using Diamond Light Source facility in Oxford
Other
Remote X-ray Data Collection Experiment using synchrotron radiation using Diamond Light Source facility in Oxford
Diamond Light Source Ltd, United Kingdom
2018/07/09 - 2018/07/13 11th CERMAX practical course on basic NMR. Course topics included basic theoretical aspects of NMR. Introduction to the most commonly used 1D and 2D homonuclear and heteronuclear techniques. Data acquisition and processing with a “hands-on” approach
Workshop
11th CERMAX practical course on basic NMR
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/06/28 - 2018/06/28 X-ray Data Collection Experiment using synchrotron radiation - Macromolecular Crystallography
Other
X-ray Data Collection Experiment using synchrotron radiation - Macromolecular Crystallography
ESRF, France
2018/06/08 - 2018/06/08 7th Nacional Meeting of Portuguese Users of Synchrotron Radiation . Anual gathering of a very special community that became interested in the use of Synchrotron Radiation for the development of new frontiers in science and technology. Representatives of three reputed institutions- ALBA (Barcelona, Spain), BESSY II (Berlin, Germany) and ESRF (Grenoble, France) Included: Poster Session- Diana O. Silva, Micael Freitas, Pedro M. Matias, Rita Ventura, Tiago M. Bandeiras, Ulrich Graedler - Exploring Cyclophilin D as an effective therapeutic drug target
Meeting
7th Nacional Meeting of Portuguese Users of Synchrotron Radiation (ENURS2018)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/04/05 - 2018/04/06 Instruct/CIISB course on fragment screening. Included: Practical sessions on pre-screening using biophysical measurements, dispensing target protein crystals to a fragment library, in situ testing of crystal diffraction; single crystal data collection and evaluation of the results. Poster session. Best Poster Award – Diana O. Silva, Micael Freitas, Pedro M. Matias, Rita Ventura, Tiago M. Bandeiras, Ulrich Graedler - New opportunities to explore Cyclophilin D as an effective therapeutic drug target. Vestec, Prague-West, Czech Republic
Workshop
Instruct/CIISB course on fragment screening using crystallography laboratory equipment - Centre of Molecular Structure (CMS), Institute of Biotechnology CAS v.v.i., BIOCEV
Instruct/CIISB course on fragment screening using crystallography laboratory equipment - Centre of Molecular Structure (CMS), Institute of Biotechnology CAS v.v.i., BIOCEV., Czech Republic
2018/03/26 - 2018/03/29 Science Communication Workshop
Workshop
Science Communication Workshop
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Mentoring / Tutoring

Topic Student name
2017/09 - 2019/01 Bioquímica para a Saúde Micael Freitas
2018 - 2018 Bioquímica para a Saúde Barbara Sousa
Distinctions

Award

2019 Poster Winner - Diana O. Silva, Pedro M. Matias, Rita Ventura, Tiago M. Bandeiras, Ulrich Graedler - Cyclophilin D as a Drug Target - Towards the discovery of new and potent CypD inhibitors
2018 Best Poster Award - Diana O. Silva, Micael Freitas, Pedro M. Matias, Rita Ventura, Tiago M. Bandeiras, Ulrich Graedler - "New opportunities to explore Cyclophilin D as an effective therapeutic drug target"
Instruct/CIISB course on fragment screening using crystallography laboratory equipment - Centre of Molecular Structure (CMS), Institute of Biotechnology CAS v.v.i., BIOCEV., Czech Republic