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Joao C Guimaraes. concluiu o Doutoramento em Artificial Intelligence em 2013/08/01 pela Universidade do Minho e Licenciatura em Engenharia de Sistemas e Informática em 2007/07/01 pela Universidade do Minho. É Investigador Coordenador Convidado (carreira) na Faculdade de Medicina da Universidade de Lisboa. Publicou 14 artigos em revistas especializadas. Participa como Investigador responsável em 1 projeto. Atua nas áreas de Ciências Exatas com ênfase em Ciências da Computação e da Informação com ênfase em Bioinformática, Ciências Exatas com ênfase em Ciências da Computação e da Informação com ênfase em Ciências da Computação, Ciências Médicas e da Saúde com ênfase em Medicina Clínica e Ciências Médicas e da Saúde com ênfase em Medicina Básica. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Cancer genomics; Functional genomics; RNA biology; Gene network; Gene expression; Tumor microenvironment; Immunology; Health Data Science; Artificial Intelligence; Personalised Medicine; .
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Identification

Personal identification

Full name
Joao C Guimaraes

Citation names

  • Guimaraes, Joao C

Author identifiers

Ciência ID
6D12-B75A-A378
ORCID iD
0000-0002-1664-472X
Google Scholar ID
8o1pjyIAAAAJ

Email addresses

  • joao.guimaraes@medicina.ulisboa.pt (Professional)

Websites

Knowledge fields

  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Exact Sciences - Computer and Information Sciences - Computer Sciences
  • Medical and Health Sciences - Clinical Medicine
  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
Education
Degree Classification
2009/03/01 - 2013/08/01
Concluded
 Artificial Intelligence (Doutoramento)
Universidade do Minho, Portugal
"Design principles for controlling gene expression" (THESIS/DISSERTATION)
2002/09/01 - 2007/07/01
Concluded
 Engenharia de Sistemas e Informática (Licenciatura)
Major in Inteligência Artificial
Universidade do Minho, Portugal
 17/20
Affiliation

Science

Category
Host institution 		Employer
2023/07/01 - Current Invited Coordinator Researcher (Research) Universidade de Lisboa, Portugal
2014/02/01 - 2018/11/30 Postdoc (Research) Universität Basel Department Biozentrum, Switzerland

Other Careers

Category
Host institution 		Employer
2021/07/01 - 2023/06/30 Coordenador Técnico (Assistente Técnico) Farfetch UK Limited, United Kingdom
2018/12/01 - 2021/06/30 Coordenador Técnico (Assistente Técnico) F Hoffmann-La Roche AG, Switzerland
2008/01/01 - 2009/02/28 Assistente Técnico (Assistente Técnico) Novabase SGPS SA, Portugal
Projects

Contract

Designation Funders
2021/01/01 - Current Informatics and Statistics for Advancement of Research Success
952377
Principal investigator
European Commission
Ongoing
2024/04/01 - 2024/09/30 iSTARS research platform for health data science
2023.13332.CPCA.A0
Principal investigator
Universidade de Lisboa Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Ana Luísa Correia; Joao C. Guimaraes; Priska Auf der Maur; Duvini De Silva; Marcel P. Trefny; Ryoko Okamoto; Sandro Bruno; et al. "Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy". Nature 594 7864 (2021): 566-571. https://doi.org/10.1038/s41586-021-03614-z.
    10.1038/s41586-021-03614-z
  2. Joao C. Guimaraes; Nitish Mittal; Alexandra Gnann; Dominik Jedlinski; Andrea Riba; Katarzyna Buczak; Alexander Schmidt; Mihaela Zavolan. "A rare codon-based translational program of cell proliferation". Genome Biology 21 1 (2020): https://doi.org/10.1186/s13059-020-1943-5.
    10.1186/s13059-020-1943-5
  3. Souvik Ghosh; Joao C Guimaraes; Manuela Lanzafame; Alexander Schmidt; Afzal Pasha Syed; Beatrice Dimitriades; Anastasiya Börsch; et al. "Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation". The EMBO Journal 39 18 (2020): https://doi.org/10.15252/embj.2019103922.
    10.15252/embj.2019103922
  4. Guillaume Cambray; Joao C Guimaraes; Adam Paul Arkin. "Evaluation of 244,000 synthetic sequences reveals design principles to optimize translation in Escherichia coli". Nature Biotechnology 36 10 (2018): 1005-1015. https://doi.org/10.1038/nbt.4238.
    10.1038/nbt.4238
  5. Katharina Essig; Nina Kronbeck; Joao C. Guimaraes; Claudia Lohs; Andreas Schlundt; Anne Hoffmann; Gesine Behrens; et al. "Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation". Nature Communications (2018): https://doi.org/10.1038/s41467-018-06184-3.
    10.1038/s41467-018-06184-3
  6. Essig K; Hu D; Guimaraes JC; Alterauge D; Edelmann S; Raj T; Kranich J; et al. "Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.". Immunity (2017): http://europepmc.org/abstract/med/29246441.
    10.1016/j.immuni.2017.11.008
  7. Nitish Mittal; Joao C. Guimaraes; Thomas Gross; Alexander Schmidt; Arnau Vina-Vilaseca; Danny D. Nedialkova; Florian Aeschimann; et al. "The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan". Nature Communications (2017): https://doi.org/10.1038/s41467-017-00539-y.
    10.1038/s41467-017-00539-y
  8. Guimaraes JC; Zavolan M. "Patterns of ribosomal protein expression specify normal and malignant human cells.". (2016): http://europepmc.org/abstract/med/27884178.
  9. Guimaraes JC; Rocha M; Arkin AP. "Transcript level and sequence determinants of protein abundance and noise in Escherichia coli.". (2014): http://europepmc.org/abstract/med/24510099.
  10. Guimaraes JC; Rocha M; Arkin AP; Cambray G. "D-Tailor: automated analysis and design of DNA sequences.". (2014): http://europepmc.org/abstract/med/24398007.
  11. Cambray G; Guimaraes JC; Mutalik VK; Lam C; Mai QA; Thimmaiah T; Carothers JM; Arkin AP; Endy D. "Measurement and modeling of intrinsic transcription terminators.". (2013): http://europepmc.org/abstract/med/23511967.
    10.1093/nar/gkt163
  12. Mutalik VK; Guimaraes JC; Cambray G; Lam C; Christoffersen MJ; Mai QA; Tran AB; et al. "Precise and reliable gene expression via standard transcription and translation initiation elements.". (2013): http://europepmc.org/abstract/med/23474465.
    10.1038/nmeth.2404
  13. Mutalik VK; Guimaraes JC; Cambray G; Mai QA; Christoffersen MJ; Martin L; Yu A; et al. "Quantitative estimation of activity and quality for collections of functional genetic elements.". (2013): http://europepmc.org/abstract/med/23474467.
    10.1038/nmeth.2403
  14. Mutalik VK; Qi L; Guimaraes JC; Lucks JB; Arkin AP. "Rationally designed families of orthogonal RNA regulators of translation.". (2012): http://europepmc.org/abstract/med/22446835.
    10.1038/nchembio.919

Other

Other output
  1. From Biological Parts to Circuit Design. Synthetic Biology. 2013. Guimaraes, Joao C.; Liu, Chang C.; Arkin, Adam P.. http://dx.doi.org/10.1016/B978-0-12-394430-6.00004-2.
    10.1016/b978-0-12-394430-6.00004-2
Activities

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/01/01 - Current Evaluator for the MSCA Postdoctoral Fellowships
Evaluator
 European Commission, Belgium European Commission

Journal scientific committee

Journal title (ISSN) Publisher
2023/01/01 - Current Frontiers
2020/01/01 - Current Bioinformatics (1367-4811) Oxford University Press
2020/01/01 - Current Nucleic Acids Research (1362-4962) Oxford University Press
2020/01/01 - Current Plos One (1932-6203) PLOS