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Claudia Nobrega is a Researcher Associate (with tenure) at the Life and Health Sciences Research Institute (ICVS) whose research interest is related to the involvement of the immune system on multiple sclerosis (MS) pathophysiology. Using a homogenous group of relapsing-remitting MS (RRMS) patients, newly-diagnosed and treatment-nai¨ve, her team was able to report that RRMS patients’ T cell phenotype in the blood tips towards a less differentiated phenotype, i.e. they present lower numbers of blood memory T cells in comparison to healthy controls (e.g. PMID 35711452). Following this observation, she was recently granted the opportunity to explore the mechanisms underlying this, and to understand how this observation can be integrated in the current model of MS pathophysiology. Additionally, and in line with the recent compelling evidence supporting that infection with the Epstein-Barr virus (EBV) precedes MS development and knowing that T cells are essential players to the establishment of the immune response to EBV infection and to MS pathophysiology, she became interested in assessing the function and the T cell receptor (TCR) repertoire of EBV specific CD8+ T cells from MS vs. EBV-seroconverted controls. Her team is exploring this issue in collaboration with Margarida Rei (Oxford University). Claudia Nobrega completed her PhD studies in 2009 studying the impact of thymic infection by mycobacteria on the differentiation of new T cells (e.g. PMID 18062904, 19949112, 23315077, 23871487). Her Post-Doc at the ICVS (2010-2019) was a turning point when she embraced human studies, to complement the mouse models she had been working with so far. She followed her interest in immunology in the context of chronic diseases, namely on infections by HIV (e.g. PMID 23437372, 26919738, 28086758, 30804925) and Mycobacterium tuberculosis (e.g. PMID 34887849), and more recently on MS (e.g. PMID 30369926, 35711452). These works were performed side-by-side with the clinicians responsible for patient recruitment, thus fostering her interaction and collaboration with the clinicians (e.g. Ines Gonzalez-Suarez at Alvaro Cunqueiro Hospital, Vigo, Spain; Ana Martins Silva at Hospital Geral Santo António, Porto, Portugal; Filipa Ladeira at Hospital Santo António dos Capuchos, Lisboa, Portugal). Her team has also been collaborating with the he Braga Clinical Academic Center (2CA-Braga) on clinical trials (e.g. Musette, Gavotte and Globeam) being responsible for performing flow cytometry of blood and cerebrospinal fluid samples from the enrolled patients. Scientific production: 23 peer-reviewed articles [ 7 as 1st author, 4 as last and 4 as corresponding author; 18 on Q1, 1 in Top 5% Journals (Scimago); h-index = 11; citations = 485 (Scopus, by Jan 26th, 2024), cumulative impact factor: 126 (from Journal Citation Report)]. Posters: Author of 78 posters presented being 40% presented on international meetings [(n=31) depicted in this CV the ones as 1st (n=15) or last (n=15) author]. Oral presentations: 3 oral presentations by invitation and 11 from selected abstracts. Supervisions: 2 PhD Students; 12 MSc students (2 ongoing); 4 BSc students; 14 Lab rotations. Juri degrees: opponent in 6 PhD thesis and 7 MSc thesis. Duties: Co-responsible for the BSL2 facility (2009-2014) and for the flow cytometer LSRII (2010 to present; training for adequate use of the instrument, quality control, troubleshooting, contact with the supplier/technician, assistance on experimental planning, data analysis and interpretation).
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Identification

Personal identification

Full name
Cláudia Rubina Freitas Pereira de Nóbrega

Citation names

  • Nobrega, Claudia

Author identifiers

Ciência ID
6D1D-5399-C3AA
ORCID iD
0000-0002-0282-9619
Researcher Id
T-6430-2018
Scopus Author Id
16481112000

Email addresses

  • claudianobrega@med.uminho.pt (Professional)

Telephones

Telephone
  • (+351) 253604917 (Professional)

Addresses

  • Instituto de Investigação em Ciências da Vida e da Saúde (ICVS), Escola de Medicina (EM), Universidade do Minho. Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2016 - 2019
Concluded
 The role of regulatory T cells on immune reconstitution of HIV-infected individuals and on the development of malignancies related to immunosuppression (Pós-doutoramento)
Universidade do Minho, Portugal
2010 - 2016
Concluded
 Characterization of T cells in HIV+ patients co-infected with tuberculosis (Pós-doutoramento)
Universidade do Minho, Portugal
2004 - 2009
Concluded
 Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Infection on the Thymus by Mycobacteria: Potential Impact on the Immune Response to Infection" (THESIS/DISSERTATION)
2004 - 2005
Concluded
 GABBA 8th ed - Graduate Program in Applied and Basic Sciences (Curso de doutoramento (conclusão de unidades curriculares))
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1997 - 2002
Concluded
 Biochemistry (5-years degree) (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Contribuição para o estudo de factores genéticos e não genéticos na actividade da Fosfatase Ácida de Baixo Peso Molecular - Estudo populacional e experimental" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2019/09 - Current Contracted Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010/01 - 2019/08 Postdoc (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009/07 - 2009/12 Research Trainee (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007/05 - 2007/10 Visiting Researcher (Research) National Institute for Medical Research, United Kingdom
2003/03 - 2004/11 Research Trainee (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2004/04 - 2004/04 Visiting Researcher (Research) Colorado State University, United States
2001/09 - 2002/10 Research Trainee (Research) Universidade de Lisboa Faculdade de Medicina, Portugal

Others

Category
Host institution 		Employer
2004/11 - 2009/06 PhD student (GABBA PhD program) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2002/10 - 2003/02 Trainee (voluntary) Universidade de Lisboa Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2023/03/01 - Current Tcells@MS_Why are peripheral T cells less mature at Multiple Sclerosis clinical onset?
2022.05294.PTDC
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2021/09 - 2023/01 COVACiMS_Assessment of SARS-COV-2 vaccine response in patients with multiple sclerosis (team member)
COVACiMS
Researcher
Grupo de Estudos em Esclerose Multipla (GEEM)

Biogen
Concluded
2020/04 - 2022/09 Reinforcing the response to COVID-19 pandemic by improving diagnostic tools and capacity (team member)
NORTE-01-0145-FEDER-072555
Researcher
Fundação para a Ciência e Tecnologia
Concluded
2018/07/15 - 2022/02 Understanding the tuberculosis transmission chains in Porto to improve control strategies (team member)
PTDC/SAU-PUB/29521/2017
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Porto Instituto de Saúde Pública, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2022/01 An intriguing mycobacterial polysaccharide: recycling, replication and beyond (team member)
PTDC/BTM-TEC/29221/2017
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e Tecnologia
Ongoing
2020/04/27 - 2020/07 Which, when and for who? Serodiagnosis as a tool to complement diagnosis and evaluate population immunity against SARS-CoV-2 (team member)
596694995
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2020 Relation between regulatory T cells and immunological hyperactivation associated co-morbilities of chronically infected HIV-infected patients (team member)
PGG/018/2017
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Concluded
2016 - 2018 Immunological ageing and a trigger for multiple sclerosis (team member)
na
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 2CA-Braga
2013/07 - 2015/06 Active tuberculosis in diabetic patients: biological basis for the increased susceptibility (team member)
125351
Provided by PTCRIS: 125351
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Porto Instituto de Saúde Pública, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
2010/04 - 2013/09 Infection of the thymus by mycobacteria: implications for the immune response, therapy and latency in tuberculosis (team member)
101663
Provided by PTCRIS: 101663
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2008 - 2011 Reconstitution and homeostasis of the immune system following HIV infection (as an active participant but not as a formal team member)
PIC/IC/83313/2007
Other
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2003 - 2004 Manipulation of interleukine-10 activity to improve the efficacy of antimycobacterial therapy (as an active participant but not as a formal team member)
POCTI/ESP/45491/2002
Other
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded

Contract

Designation Funders
2023/03/01 - 2026/02/28 Exploiting the immune landscape of HOXA9/WNT6-driven glioblastoma: opportunities for novel precision therapies
2022.04859.PTDC
10.54499/2022.04859.PTDC
Researcher
Universidade do Minho, Portugal

Instituto de Investigaciones Biomédicas Sols-Morreale, Spain

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016 - 2019 The role of regulatory T cells on immune reconstitution of HIV-infected individuals and on the development of malignancies related to immunosuppression
SFRH/BPD/112001/2015
Post-doc Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
2010 - 2016 Characterization of T cells in HIV+ patients with tuberculosis
SFRH/BPD/65380/2009
Post-doc Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2009 Infection of the thymus by mycobacteria: potential impact on the immune response to infection
SFRH/BD/15243/2004
PhD Student Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
2003 - 2004 Generation of a novel experimental model to study the role played by T lymphocytes in infections by Mycobacterium avium and M. tuberculosis
POCTI/39791
Integration into Research Grant Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2001 - 2002 Contribuição para o estudo de factores genéticos e não genéticos na atividade da Fosfatase Ácida de Baixo Peso Molecular – estudo populacional e experimental
PRODEP - acção 3.2 - Estágios Curriculares, Concurso Público no 1/3.2/PRODEP/2001
Integration into Research Grant Fellow
Universidade de Lisboa Faculdade de Medicina, Portugal
Outputs

Publications

Conference poster
  1. Alves-Peixoto, P.; Ramos Fernandes, C.; Canto-Gomes, J.; S. Silva, C.; Horta, A.; Correia-Neves, M.; Nobrega, C.. "HIV-infected patients on antiretroviral therapy have transient lower numbers of Natural Killer cells with an altered phenotype". Paper presented in 1st ImmunoHub Annual Meeting, 2023.
  2. Alves-Peixoto, P.; Ramos Fernandes, C.; Canto-Gomes, J.; S. Silva, C.; Horta, A.; Correia-Neves, M.; Nobrega, C.. "HIV-infected patients on antiretroviral therapy have transient lower numbers of Natural Killer cells with an altered phenotype". Paper presented in XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023.
  3. Canto-Gomes, J.; S. Silva, C.; Boleixa, D.; Teixeira, C.; Martins da Silva, A.; González-Suaréz, I.; Cerqueira, J. J.; Correia-Neves, M.; Nobrega, C. ""Distinct disease modifying therapies are associated with distinct immune profiles in people with relapsing multiple sclerosis". Paper presented in XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023.
  4. Canto-Gomes, J.; Silva, C.S.; Rb-Silva, R.; Boleixa, D.; Martins da Silva, A.; Cheynier, R.; Costa, P.; et al. "Low memory T cells blood counts and high naïve regulatory T cells percentage at relapsing remitting multiple sclerosis diagnosis". Paper presented in XLVII SPI Annual Meeting, 2022.
  5. Alves-Peixoto, P.; Canto-Gomes, J.; Silva, C.S.; Rb-Silva, R.; Horta, A.; Sigal, L,; Campbell, K.S.; Correia-Neves, M.; Nobrega, C.. "HIV-infected patients undergoing antiretroviral therapy have persistently reduced numbers of Natural Killer cells with an altered phenotype". Paper presented in XVII Congress of the Iberian Society of Cytometry. Web Symposium, 2021.
  6. Canto-Gomes, J.; Silva, C.S.; Cerqueira, J.J.; Rb-Silva, R.; González, I.; Boleixa, D.; Martins, A.; Correia-Neves, M.; Nobrega, C.. "Higher naïve to memory T cells and altered regulatory cells characterize Multiple Sclerosis at clinical onset". Paper presented in XVII Congress of the Iberian Society of Cytometry. Web Symposium, 2021.
  7. Canto-Gomes, J.; Silva, C.S.; Cerqueira, J.J.; Rb-Silva, R.; González-Suaréz, I.; Boleixa, D.; Martins da Silva, A.; Correia-Neves, M.; Nobrega, C.. "Reduced memory T cells, less suppresive regulatory T cells and NK cells prone to be inhibited characterize Multiple Sclerosis at clinical onset". Paper presented in Symposium on Neuro-Immune Interations - Conte Center for Neuroimmune Studies. Web Symposium, 2021.
  8. Alves-Peixoto, P.; Canto-Gomes, J.; Silva, C. S.; Rb-Silva, R.; Horta, A.; Sigal, L. J.; Campbell, K.S.; Correia-Neves, M.; Nobrega, C. "The phenotype of Natural Killer cells during HIV infection in patients undergoing antiretroviral therapy". Paper presented in XLVI SPI Annual Meeting 2021. Web Symposium, 2021.
  9. Canto-Gomes, J.; Silva, C. S.; Cerqueira, J.J.; Rb-Silva, R.; González-Suaréz, I.; Boleixa, D.; Martins da Silva, A.; Correia-Neves, M.; Nobrega, C.. "Profound alterations on peripheral blood cell populations are present on relapse-remitting multiple sclerosis patients at disease onset". Paper presented in XLVI SPI Annual Meeting 2021, 2021.
  10. Canto-Gomes, J.; Silva, C. S.; Rb-Silva, R.; González-Suaréz, I.; Boleixa, D.; Martins da Silva, A.; Correia-Neves, M.; Cerqueira, J. J.; Nobrega, C.. "Lower numbers of blood central memory T cells and altered phenotype of regulatory cells are present in newly diagnosed relapsing-remitting Multiple Sclerosis patients". Paper presented in European Congress in Immunology. Web conference., 2021.
    https://doi.org/10.1002/eji.202170200
  11. Canto-Gomes, J.; Silva, C. S.; Rb-Silva, R.; González-Suaréz, I.; Boleixa, D.; Martins da Silva, A.; Correia-Neves, M.; Cerqueira, J. J.; Nobrega, C.. "Profound alterations on T cell subsets and on regulatory cells characterize Multiple Sclerosis at clinical onset.". Paper presented in Annual Congress of the European Committee for Treatment and Research in Multiple Sclerosis - ECTRIMS, 2021.
    https://doi.org/10.1177/13524585211044667
  12. Nobrega, C.; Coutinho-Teixeira, V.; Portugal-Nunes, C.; Horta, A.; Correia-Neves, M.. "Risk factors for the development of tuberculosis in human immunodeficiency virus-infected patients: a longitudinal retrospective study". Paper presented in 1st Symposium on Research on Tuberculosis and Non-Tuberculosis Mycobacteria in Portugal, 2018.
    Editor
  13. Canto-Gomes, J.; Rb-Silva, R.; Cerqueira, J.J.; Correia-Neves, M.; Nobrega, C.; Silva, C.S.. "Impact of immune system aging on multiple sclerosis’ forms of progression: study of the thymic function". Paper presented in XLII Annual Meeting of the Portuguese Society for Immunology. Porto, Portugal, 2017.
  14. Nobrega, C.; Horta, A.; Ribeiro, A.; Coutinho-Teixeira, V.; Baldaia, A.; Santos, C.L.; Correia-Neves, M.. "The Dynamics of Regulatory T Cells on the Immune Recovery of Individuals Infected by the Human Immunodeficiency Virus on Antiretroviral Therapy". Paper presented in XL Annual Meeting of the Portuguese Society of Immunology. Lisbon, Portugal., 2014.
  15. Nobrega, C.; Santos, C.L.; Amorim-Machado, P.; Horta, A.; Duarte, R.; Correira-Neves, M.. "A retrospective study on the risk of developing tuberculosis among HIV+ patients". Paper presented in XL Annual Meeting of the Portuguese Society of Immunology. Lisbon, Portugal., 2014.
  16. Nobrega, C.; A. Amorim; Sarmento-Castro, R.; Horta, A.; Castro, A.G.; Correia-Neves, M.; Amorim-Machado, P.. "Antiretroviral therapy initiation: how low can we go on CD4+ T cell counts avoiding increased susceptibility to tuberculosis?". Paper presented in Tuberculosis: from the hospital to the bench and back. Braga, Portugal., 2012.
  17. Nobrega, C.; Nunes-Alves, C.; Cerqueira-Rodrigues, B.; Roque, S.; Barreira-Silva, P.; Behar, S.M.; Correia-Neves, M.. "Do mycobacteria within the thymus promote an adaptive immune response?". Paper presented in Tuberculosis: from the hospital to the bench and back. Braga, Portugal., 2012.
  18. Nobrega, C.; Nunes-Alves, C.; Cerqueira-Rodrigues, B.; Roque, S.; Barreira-Silva, P.; Behar, S.M.; Correia-Neves, M.. "Is the control of mycobacterial growth within the thymus a job for T cells re-circulating from the periphery?". Paper presented in Thymus@Porto. Porto, Portugal, 2011.
  19. Nobrega, C.; Nunes-Alves, C.; Coelho, A.; Roque, S.; Medeiros, I.; Barreira-Silva, P.; Correira-Neves, M.. "Evidence for an immune response to Mycobacterium avium in the thymus". Paper presented in Cell Inflammation and Disease Conference – Cell Symposia. Lisbon, Portugal, 2010.
  20. Nobrega, C.; Nunes-Alves, C.; Coelho, I.; Cerqueira-Rodrigues, B.; Roque, S.; Correia-Neves, M.. "Mycobacterium avium infection leads to a delayed and distinct immune response in the thymus in comparison to the spleen". Paper presented in XXXVI Annual Meeting of the Portuguese Society for Immunology. Braga, Portugal, 2010.
  21. Nobrega, C.; Nunes-Alves, C.; Coelho, I.; Roque, S.; Medeiros, A.; Barreira-Silva, P.; Correia-Neves, M.. "Evidence for a delayed and distinct immune response to Mycobacterium avium in the thymus in comparison to the spleen". Paper presented in XXXV Annual Meeting of the Portuguese Society for Immunology. Lisbon, Portugal, 2010.
  22. Nobrega, C.; Roque, S.; Appelberg, R.; Correia-Neves, M.. "Reduced efficacy of anti-mycobacterial drugs for bacteria within the thymus". Paper presented in NITD Symposium on Tuberculosis. Maputo, Mozambique, 2008.
  23. Nobrega, C.; Castro, A.G.; Roque, S.; Appelberg, R.; Correia-Neves, M.. "Mycobacterium avium infection of the thymus leads to abnormal T cell differentiation". Paper presented in 7th International Conference of Pathogenesis of Mycobacterial Infections. Saltsjöbaden, Sweden, 2008.
  24. Nobrega, C.; Roque, S.; Appelberg, R.; Correia-Neves, M.. "Newly produced T cells do not play a major role in controlling Mycobacterium avium chronic infection". Paper presented in XXXII Annual Meeting of the Portuguese Society of Immunology. Braga, Portugal, 2006.
  25. Nobrega, C.; Pires Bicho, M.. "Modulation of low molecular weight acid phosphatase and transmenbrane oxidoreductase system activities by extracellular oxidants". Paper presented in XII National Biochemistry Meeting. Lisbon, Portugal, 2002.
  26. Nobrega, C.; Pereira da Silva, A.; Moreira, M.; Sardinha, L.B.; Loblet, S.; Laires, M.J.; Pires Bicho, M.. "Erythrocyte's low molecular weight acid phosphatase: from the genetic to the biochemical phenotype". Paper presented in IV Meeting of the Portuguese Society of Human Genetics. Porto, Portugal, 2002.
Journal article
  1. Canto-Gomes, J; Boleixa, D; Teixeira, C; Martins da Silva, A; González-Suárez, I; Cerqueira, J*; Correia-Neves, M*; Nobrega, C*#. "Distinct disease-modifying therapies are associated with different blood immune cell profiles in people with relapsing-remitting multiple sclerosis". International Immunopharmacology 131 (2024): 111826. http://dx.doi.org/10.1016/j.intimp.2024.111826 # Corresponding Author.
    Open access • 10.1016/j.intimp.2024.111826
  2. Canto-Gomes, J.; Da Silva-Ferreira, S.; S. Silva, C.; Boleixa, D; Martins da Silva, A; González-Suaréz, I.; Cerqueira, J. J.; Correia-Neves, M.; Nobrega, C.#. "People with Primary Progressive Multiple Sclerosis Have a Lower Number of Central Memory T Cells and HLA-DR+ Tregs". Cells (2023): https://doi.org/10.3390/cells12030439. # Corresponding Author.
    Open access • 10.3390/cells12030439
  3. Canto-Gomes, J.; S. Silva, C.; Rb-Silva, R.; Boleixa, D; Martins da Silva, A; Cheynier, R.; Costa, P.; et al. "Low Memory T Cells Blood Counts and High Naïve Regulatory T Cells Percentage at Relapsing Remitting Multiple Sclerosis Diagnosis". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.901165. # Corresponding Author.
    Open access • 10.3389/fimmu.2022.901165
  4. Gallo, V.; Reis, A.; Miranda, A.; Martins, C.; Serre-Miranda, C.; Nobrega, C.; Silva, C. S.; et al. "Increased Gal-3BP plasma levels in hospitalized patients infected with SARS-CoV-2". Clinical and Experimental Medicine (2022): http://dx.doi.org/10.1007/s10238-021-00788-8.
    Open access • 10.1007/s10238-021-00788-8
  5. Barreira-Silva, P.; Melo-Miranda, R.; Nobrega, C.; Roque, S.; Serre-Miranda, C.; Borges, M.; Armada, G.; et al. "IFNg and iNOS-Mediated Alterations in the Bone Marrow and Thymus and Its Impact on Mycobacterium avium-Induced Thymic Atrophy". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.696415.
    Open access • 10.3389/fimmu.2021.696415
  6. Silva, C. S.; Sundling, C.; Folkesson, E.; Fröberg, G.; Nobrega, C.; Canto-Gomes, J.; Chambers, B. J.; et al. "High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation With Mycobacterial Glycolipids". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.727300.
    Open access • 10.3389/fimmu.2021.727300
  7. Serre-Miranda, C.; Roque, S.; Barreira-Silva, P.; Nobrega, C.; Vieira, N.; Costa, P.; Almeida Palha, J.; Correia-Neves, M.. "Age-Related Sexual Dimorphism on the Longitudinal Progression of Blood Immune Cells in BALB/cByJ Mice". The Journals of Gerontology: Series A (2021): http://dx.doi.org/10.1093/gerona/glab330.
    Open access • 10.1093/gerona/glab330
  8. Miranda, C*; Nobrega, C.*; Roque, S.*; Silva, C.S.; Canto-Gomes, J.; Vieira, N.; Barreira-Silva, P.; et al. "Performance assessment of 11 commercial serological tests for SARS-CoV-2 on hospitalized COVID-19 patients". International Journal of Infectious Diseases 104 (2021): 661-669. http://dx.doi.org/10.1016/j.ijid.2021.01.038. * Authors contributed equally to the work.
    Open access • In press • 10.1016/j.ijid.2021.01.038
  9. Rb-Silva, R.; Nobrega, C.; Azevedo, C.; Athayde, E.; Canto-Gomes, J.; Ferreira, I.; Cheynier, R.; et al. "Thymic Function As a Predictor of Immune Recovery in Chronically HIV-Infected Patients Initiating Antiretroviral Therapy". Frontiers in Immunology 10 (2019): 25. https://www.frontiersin.org/articles/10.3389/fimmu.2019.00025/full.
    Open access • 10.3389/fimmu.2019.00025
  10. das Neves, S.P.; Serre-Miranda, C.; Nobrega, C.; Roque, S.; Cerqueira, J.J.; Correia-Neves, M.; Marques, F.. "Immune Thymic Profile of the MOG-Induced Experimental Autoimmune Encephalomyelitis Mouse Model.". Frontiers in immunology 9 (2018): 2335. https://www.frontiersin.org/articles/10.3389/fimmu.2018.02335/full.
    Open access • 10.3389/fimmu.2018.02335
  11. Cerqueira-Rodrigues, B.; Cardona, P.G.; Ana Mendes; Margarida Correia-Neves; Nobrega, C.#. "Ag85-focused T-cell immune response controls Mycobacterium avium chronic infection". PLOS ONE 13 3 (2018): e0193596. https://doi.org/10.1371/journal.pone.0193596. # Corresponding Author.
    Open access • 10.1371/journal.pone.0193596
  12. Rb-Silva, R.*; Nobrega, C.*; Reiriz, E.; Almeida, S.; Sarmento-Castro, R.; Correia-Neves, M.; Horta, A.. "Toxoplasmosis-associated IRIS involving the CNS: A case report with longitudinal analysis of T cell subsets". BMC Infectious Diseases 17 (2017): 66. https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-2159-x. * Authors contributed equally to the work.
    Open access • 10.1186/s12879-016-2159-x
  13. Nobrega, C.#; Horta, A.; Coutinho-Teixeira, V.; Martins-Ribeiro, A.; Baldaia, A.; Rb-Silva, R.; Santos, C.L.; Sarmento-Castro, R.; Correia-Neves, M.. "Longitudinal evaluation of regulatory T-cell dynamics on HIV-infected individuals during the first 2 years of therapy". AIDS 30 8 (2016): 1175. https://journals.lww.com/aidsonline/Fulltext/2016/05150/Longitudinal_evaluation_of_regulatory_T_cell.3.aspx. # Corresponding Author.
    Open access • 10.1097/QAD.0000000000001074
  14. Fernandes, E.; Martins, V.C.; Nobrega, C.; Carvalho, C.M.; Cardoso, F.A.; Cardoso, S.; Dias, J.; et al. "A bacteriophage detection tool for viability assessment of Salmonella cells". Biosensors and Bioelectronics 52 (2014): 239. https://www.sciencedirect.com/science/article/pii/S0956566313006027?via%3Dihub.
    10.1016/j.bios.2013.08.053
  15. Nunes-Alves, C.; Nobrega, C.; Behar, S.M.; Correia-Neves, M.. "Tolerance has its limits: How the thymus copes with infection". Trends in Immunology 34 10 (2013): 502. https://www.cell.com/trends/immunology/fulltext/S1471-4906(13)00094-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS147149061300094X%3Fshowall%3Dtrue.
    10.1016/j.it.2013.06.004
  16. Afonso-Barroso, A.; Clark, S.O.; Williams, A.; Rosa, G.T.; Nobrega, C.; Silva-Gomes, S.; Vale-Costa, S.; et al. "Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses". Cellular Microbiology 15 4 (2013): 660. https://onlinelibrary.wiley.com/doi/full/10.1111/cmi.12065.
    10.1111/cmi.12065
  17. Horta, A.*; Nobrega, C.*; Amorim-Machado, P.; Coutinho-Teixeira, V.; Barreira-Silva, P.; Boavida, S.; Costa, P.; et al. "Poor Immune Reconstitution in HIV-Infected Patients Associates with High Percentage of Regulatory CD4+ T Cells". PLoS ONE 8 2 (2013): https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057336. * Authors contributed equally to the work.
    Open access • 10.1371/journal.pone.0057336
  18. Nobrega, C.*; Nunes-Alves, C.*; Cerqueira-Rodrigues, B.; Roque, S.; Barreira-Silva, P.; Behar, S.M.; Correia-Neves, M.. "T cells home to the thymus and control infection". Journal of Immunology 190 4 (2013): 1646-1658. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873543205&partnerID=MN8TOARS. * Authors contributed equally to the work.
    10.4049/jimmunol.1202412
  19. Duarte, R.; Afonso, A.; Ferreira, C.; Roque, S.; Vasconcelos, O.; Sarmento-Castro, R.; Tavares, M.; et al. "A case-control study on the diagnostic potential of multi-antigen serological tests for tuberculosis". Archives of Clinical Microbiology 3 2 (2012): 1. http://www.acmicrob.com/microbiology/a-casecontrol-study-on-the-diagnostic-potential-of-multiantigen-serological-tests-for-tuberculosis.php?aid=156.
    10.3823/249
  20. Roque, S.; Oliveira, T.G.; Nobrega, C.; Barreira-Silva, P.; Nunes-Alves, C.; Sousa, N.; Palha, J.A.; Correia-Neves, M.. "Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration". Frontiers in Behavioral Neuroscience 5 (2011): 4. https://www.frontiersin.org/articles/10.3389/fnbeh.2011.00004/full.
    10.3389/fnbeh.2011.00004
  21. Olsson, I.A.S.; Costa, A.; Nobrega, C.; Roque, S.; Correia-Neves, M.. "Environmental enrichment does not compromise the immune response in mice chronically infected with mycobacterium avium". Scandinavian Journal of Immunology 71 4 (2010): 249. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-3083.2010.02371.x.
    10.1111/j.1365-3083.2010.02371.x
  22. Nobrega, C.; Roque, S.; Nunes-Alves, C.; Coelho, A.; Medeiros, I.; Castro, A.G.; Appelberg, R.; Correia-Neves, M.. "Dissemination of mycobacteria to the thymus renders newly generated T cells tolerant to the invading pathogen". Journal of Immunology 184 1 (2010): 351. https://www.jimmunol.org/content/184/1/351.long.
    10.4049/jimmunol.0902152
  23. Roque, S.; Nobrega, C.; Appelberg, R.; Correia-Neves, M.. "IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy". Journal of Immunology 178 12 (2007): 8028. https://www.jimmunol.org/content/178/12/8028.long.
    10.4049/jimmunol.178.12.8028
  24. Nobrega, C.; Cardona, P.-J.; Roque, S.; Pinto do Ó, P.; Appelberg, R.; Correia-Neves, M.. "The thymus as a target for mycobacterial infections". Microbes and Infection 9 14-15 (2007): 1521-1529. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749031173&partnerID=MN8TOARS.
    10.1016/j.micinf.2007.08.006
Preprint
  1. Canto-Gomes, J; Boleixa, D; Teixeira, C; Martins da Silva, A; González-Suaréz, I.; Cerqueira, J.*; Correia-Neves, M*; Nobrega, C.*#. "Distinct disease-modifying therapies are associated with different blood immune cell profiles in people with relapsing-remitting multiple sclerosis". 2023. https://doi.org/10.1101/2023.07.20.549852. * Equal contributers; # Corresponding author .
    10.1101/2023.07.20.549852
  2. Canto-Gomes, J.; Silva, C. S.; Rb-Silva, R.; Boleixa, D.; Martins da Silva, A.; Cheynier, R.; Costa, P.; et al. "Low memory T cells blood counts and high naïve regulatory T cells percentage at relapsing remitting multiple sclerosis diagnosis". 2022. http://dx.doi.org/10.1101/2022.03.07.483243. # Corresponding author.
    10.1101/2022.03.07.483243
  3. Barreira-Silva, P.; Melo-Miranda, R.; Nobrega, C.; Roque, S.; Serre-Miranda, C.; Borges, M.; de Sá Calçada, D.; et al. "IFN-gamma and iNOS-mediated alterations in the bone marrow and thymus and its impact on Mycobacterium avium-induced thymic atrophy". 2021. http://dx.doi.org/10.1101/2021.02.23.432464.
    10.1101/2021.02.23.432464
  4. Silva, C. S.; Sundling, C.; Folkeson, E.; Fröberg, Gabrielle; Nobrega, C; Canto-Gomes, J.; Chambers, B. J.; et al. "Stimulation with mycobacterial glycolipids and PPD reveals different innate immune response profiles in active and latent TB". 2021. http://dx.doi.org/10.1101/2021.04.04.434373.
    10.1101/2021.04.04.434373
  5. Serre-Miranda, C.*; Nobrega, C*; Roque, S*; Canto-Gomes, J.; Silva, C. S.; Vieira, N.; Barreira-Silva, P.; et al. "Performance assessment of 11 commercial serological tests for SARS-CoV-2 on hospitalized COVID-19 patients". 2020. http://dx.doi.org/10.1101/2020.08.06.20168856.
    10.1101/2020.08.06.20168856
Thesis / Dissertation
  1. Nobrega, Claudia. "Infection of the thymus by micobacteria: potential impact on the immune response to infection". PhD, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2009.
  2. Nobrega, Claudia. "Contribuição para o estudo de factores genéticos e não genéticos na atividade da Fosfatase Ácida de Baixo Peso Molecular – estudo populacional e experimental". Degree, Fundação da Faculdade de Ciências da Universidade de Lisboa, 2002.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021 "FlowFish: assessment of relative telomere length by flow cytometry". Invited Speaker. XVII Congress of the Iberian Society of Cytometry (Web Symposium)
Iberian Society of Cytometry
2012 "How much does the human immunodeficiency vírus (HIV) infection increase the risk of tuberculosis in Porto?" C. Nobrega, P. Amorim-Machado, A. Horta, M. Correia-Neves. Abstract selected for oral presentation by C. Nobrega. XXXVIII Annual Meeting of the Portuguese Society of Immunology
Portuguese Society of Immunology (Porto)
2012 “HIV immunopathogenesis: from the first hours to up to 6 months. The vírus". Invited speaker. II Meeting in Infection and Immunity
(Viana do Castelo, Portugal)
2011 "Immune response and T cell recirculation in infected thymi: two (in)dependent processe" C. Nobrega, C. Nunes-Alves, B. Rodrigues, S. Behar, M. Correia-Neves. Abstract selected for oral presentation by M. Correia-Neves (as C. Nobrega was on maternal leave). 8th International Conference of Pathogenesis of Mycobacterial Infections
(Saltsjöbaden, Sweden)
2011 “Is T cell recirculation back to the thymus responsible for the immune response to infection in this organ?”. C. Nobrega, C. Nunes-Alves, B. Rodrigues, S. Roque, S. Behar, M. Correia-Neves. Abstract selected for oral presentation by C. Nobrega International School of Immunology
Portuguese Society of Immunology (Tavira, Portugal)
2007 “Mature activated CD4+ T cells re-circulate to the thymus during Mycobacterium avium chronic infection”. C. Nobrega, S. Roque, G. Castro, R. Appelberg, M. Correia Neves. Abstract selected for oral presentation by C. Nobrega XXXIII Annual Meeting of the Portuguese Society of Immunology
Portuguese Society of Immunology (Lisbon, Portugal)
2005 “Thymus as a target organ for mycobacterial infections”. C. Nobrega, P.J. Cardona, P. Pinto do Ó, E. Guirado, R. Appelberg, M. Correia-Neves. Abstract selected for oral presentation by C. Nobrega XXXI Annual Meeting of the Portuguese Society of Immunology
Portuguese Society of Immunolog (Lisbon, Portugal)
2002 “Epinephrin oxidase and low molecular weight acid phosphatase in diabetic retinopathy”. A.P. Silva, C. Nobrega, I. Osório, T. Quintão, M. P. Bicho, P. Ramalho. Abstract selected for oral presentation by C. Nobrega XLV Portuguese Meeting of Ophthalmology
Portuguese Society for Ophthalmology (Funchal, Portugal)
2002 “Preliminary study on the association of two enzymes involved in oxidative stress with diabetic retinopathy". A.P. Silva, C. Nobrega, I. Osório, T. Quintão, M. P. Bicho, P. Ramalho. Abstract selected for oral presentation by C. Nobrega XLV Portuguese Meeting of Ophthalmology
Portuguese Ophthalmology Society (Funchal, Portugal)
2002 “Modulation of low molecular weight acid phosphatase and transmebranar oxidoreductase system activities by dietary flavonoids”. C. Nobrega, V. Lança, M. P. Bicho. Abstract selected for oral presentation by C. Nobrega Workshop on Nutrients, Functional Foods and Atherosclerosis
(Almancil, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/01 - Current Epstein-Barr virus-specific T cells in people with multiple sclerosis: assessing HLA-E restricted T cell function and receptor diversity
Supervisor
 Integrated MSc in Medicine (Master)
Universidade do Minho Escola de Medicina, Portugal
2023/09 - Current Why are peripheral T cells less mature at Multiple Sclerosis clinical onset?
Supervisor
 MSc in Biochemistry (Master)
Universidade do Minho Escola de Ciências, Portugal
2019 - 2023 T cell differentiation as a core component of Multiple Sclerosis pathogenesis
Supervisor of João Canto-Gomes
 PhD in Aging and Chronic Diseases (PhDOC) (PhD)
Universidade do Minho Escola de Medicina, Portugal
2022/01 - 2022/06 Evaluation of natural killer cell dysfunction in HIV-infected patients on antiretroviral therapy.
Supervisor
 BSc in Biology (Degree)
Universidade de Aveiro Departamento de Biologia, Portugal
2020/01 - 2021/01 HIV-infected patients undergoing antiretroviral therapy have persistently reduced numbers of Natural Killer cells with an altered phenotype
Supervisor of Pedro Peixoto
 Integrated MSc in Medicine (Master)
Universidade do Minho Escola de Medicina, Portugal
2012 - 2020 Thymic infection and T cell immunodominance during Mycobacterium avium infection
Co-supervisor of Bruno Cerqueira-Rodrigues
 PhD in Health Sciences: (PhD)
Universidade do Minho Escola de Medicina, Portugal
2018 - 2019 Influence of HOXA9 in the response of glioblastoma to immune checkpoint inhibitors
Co-supervisor of Catarina Azevedo
 MSc in Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2017 - 2017 The impact of immune system’s aging on multiple sclerosis disease progression
Supervisor of Inês Lages
 BSc in Applied Biology (Degree)
Universidade do Minho Escola de Ciências, Portugal
2016 - 2017 Impact of the immune system aging on multiple sclerosis forms of progression: study of the thymic function
Supervisor of João Canto-Gomes
 MSc in Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2015 - 2015 HIV infection: from the evaluation of a new diagnostic test for the tuberculosis co-infection to the immune reconstitution during antiretroviral therapy
Supervisor of João Canto-Gomes
 BSc in Applied Biology
Universidade do Minho Escola de Ciências, Portugal
2013 - 2014 A multiparametric assessment of thymic activity on HIV-infected individuals on antiretroviral therapy
Co-supervisor of Ana Martins-Ribeiro
 MSc in Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2013 - 2014 Evaluation of regulatory T cells progression in HIV infected patients on antiretroviral therapy
Supervisor of Ana Patrícia Baldaia
 Integrated MSc in Medicine (Master)
Universidade do Minho Escola de Medicina, Portugal
2013 - 2014 Evaluation of thymic function in HIV-infected individuals through antiretroviral therapy
Co-supervisor of Tiago Fernandes
 Integrated MSc in Medicine (Master)
Universidade do Minho Escola de Medicina, Portugal
2011 - 2012 Thymic activity and immune reconstitution in HIV-infected patients: Looking for a reciprocity
Co-supervisor of Vítor Coutinho-Teixeira
 Master in Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2010 - 2011 Characterization of thymic imune response to mycobacteria infections
Co-supervisor of Bruno Cerqueira-Rodrigues
 MSc in Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2010 - 2010 Thymic infection by Mycobacterium avium: characterization of thymic dendritic cells
Supervisor of Ângela Fernandes
 BSc in Applied Biology
Universidade do Minho Escola de Ciências, Portugal
2009 - 2009 Study of infection of the thymus by Mycobacterium avium on the development of the peripheral immune response
Co-supervisor of Irene Medeiros
 Integrated MSc in Medicine (Master)
Universidade do Minho Escola de Medicina, Portugal
2009 - 2009 The thymic cytokine profile in response to the infection to Mycobacterium avium
Co-supervisor of Ângela Coelho
 Integrated MSc in Medicine (Master)
Universidade do Minho Escola de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/04 - 2023/04 "5th ed. Cell functional and phenotypical analysis: the usefulness of flow cytometry and related tools". Advanced course from the MSc and PhD programs (100 hours). Strong hands-on component; brings national and international experts. Co-organizer and member of the teaching staff. (2023 - 2023)
Workshop (Co-organisor)
 Universidade do Minho Escola de Medicina, Portugal
2021/03/02 - 2021/03/23 "4th ed. Cell functional and phenotypical analysis: the usefulness of flow cytometry and related tools". Advanced course from the MSc and PhD programs (100 hours). Strong hands-on component; brings national and international experts. Co-organizer and member of the teaching staff. (2021)
Workshop (Co-organisor)
 Universidade do Minho Escola de Medicina, Portugal
2019/02/11 - 2019/02/28 "3rd ed. Cell functional and phenotypical analysis: the usefulness of flow cytometry and related tools". Advanced course from the MSc and PhD programs (100 hours; 15 participants). Strong hands-on component; brings national and international experts. Co-organizer and member of the teaching staff. (2019)
Workshop (Member of the Organising Committee)
 Universidade do Minho Escola de Medicina, Portugal
2017/03/13 - 2017/03/31 "2nd ed. Cell functional and phenotypical analysis: the usefulness of flow cytometry and related tools". Advanced course from the MSc and PhD programs (100 hours; 15 participants). Strong hands-on component; brings national and international experts. Rated as "very-good" (highest score) by the participants. Co-organizer and member of the teaching staff. (2017)
Workshop (Member of the Organising Committee)
 Universidade do Minho Escola de Medicina, Portugal
2017 - 2017 Organisor of the Annual Retreat of the Microbiology and Infection Research Domain (MIRD). This 2-days retreat was held in Ribeira de Pena, Portugal. (2017 - 2017)
Meeting (Co-organisor)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2011 - 2017 Outreach Activities. 2011, 2012, 2014, 2016 and 2017: "Epidemia da Ciência", Portas Abertas initiative. Instructor of the laboratory activity or speaker (dislocated to schools for a talk). (2011 - 2017)
Other (Other)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/03/29 - 2016/04/08 "1st ed. Cell functional and phenotypical analysis: the usefulness of flow cytometry and related tools". Advanced course from the MSc and PhD programs (100 hours; 12 participants). Strong hands-on component; brings national and international experts. Rated as "very-good" (highest score) by the participants. Co-organizer and member of the teaching staff. (2016)
Workshop (Member of the Organising Committee)
 Universidade do Minho Escola de Medicina, Portugal
2008 - 2012 Outreach Activities. 2008, 2009, 2010 & 2012: "Ácido-base", Portas Abertas initiative. Instructor of the laboratory activity. (2008 - 2012)
Other (Other)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023 - 2023 Workshop de Boas práticas na Orientação Doutoral.
Workshop
Universidade do Minho, Portugal
2020 - 2020 Outcome evaluation of public health interventions: The main topics of this course were: (i) How to formulate an evaluation question; (ii) Study design in the evaluation of complex interventions: strengths and weaknesses; (iii) How to write an evaluation protocol; (iv) Planning the evaluation. This course was given by Rosaria Galanti (Karolinska Institute)) Attendee (20-hours course)
Seminar
 Outcome evaluation of public health interventions
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020 - 2020 Multivariate data analysis: methods for grouping variables. Course delivered by Patricio Costa (School of Medicine, University of Minho. Attendee (8-hours course)
Workshop
 Multivariate data analysis: methods for grouping variables
Universidade do Minho, Portugal
2020 - 2020 Multivariate data analysis: methods for grouping subjects. Course delivered by Patricio Costa (School of Medicine, University of Minho. Attendee (8-hours course)
Workshop
 Multivariate data analysis: methods for grouping subjects.
Universidade do Minho, Portugal
2020 - 2020 Multivariate data analysis: introduction to structural equational modeling and path analysis. Course delivered by Patricio Costa (School of Medicine, University of Minho. Attendee (12-hours course)
Workshop
 Multivariate data analysis: introduction to structural equational modeling and path analysis
Universidade do Minho, Portugal
2018 - 2018 2nd FLxFlow Course (Advanced Module): This course covered advanced flow cytometry topics and comprised lectures and practical modules taught by national and international experts in the field. Flow cytometry applications were offered and were taught on different instruments in hands-on sessions. Atendee (18-hours course)
Workshop
 2nd FLxFlow Course (Advanced Module)
Instituto Gulbenkian de Ciência, Portugal
2016 - 2016 Imaging Flow Cytometry. Course on basic concepts of Imaging Flow Cytometry, from sample preparation, to acquisition and analysis. Attendee (15-hours course)
Workshop
 Imaging Flow Cytometry
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014 - 2014 Laboratory Animal Sciences (LAS) - FELASA C. This theoretical and practical course aims to prepare researchers for the appropriate use of animals in scientific experiments (from the biology and husbandry of laboratory animals, aspects of microbiology and disease, health hazards and safe practices in the animal house, the design and conduct of animal experiments, anaesthesia, analgesia and experimental procedures, as well as the ethical and legal aspects of animal experimentation and alternatives to animal use). Attendee (100-hours course)
Workshop
 Laboratory Animal Sciences (LAS) - FELASA C
Universidade do Minho Escola de Medicina, Portugal
2013 - 2013 Statistic models for longitudinal data. Attendee (20-hours course)
Workshop
 Statistical Models for Longitudinal Analysis
Universidade do Minho Centro Interdisciplinar de Ciências Sociais, Portugal
2013 - 2013 Introduction to linear and logistic regression models. Course delivered by Patricio Costa (School of Medicine, University of Minho). Attendee (12-hours course)
Workshop
 Topics of Regression with IBM SPSS statistics
Universidade do Minho Escola de Medicina, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024 Inveiling the role of CD1a in human regulatory T cell development
(Thesis) Main arguer
 Nicole Martins (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023 Host genetics of resistance to Mycobacterium ulcerans infection: bridging clinical and cellular/animal models
(Thesis) Arguer
 João Fevereiro (PhD)
Universidade do Minho Escola de Medicina, Portugal
2023 Antimicrobial flexible coating material for the car sharing segment of the automotive industry
(Thesis) Arguer
 Tiago Costa (PhD)
Universidade do Minho Escola de Medicina, Portugal
2022 Microbiota Regulation of Cancer Immune Surveillance
(Thesis) Arguer
 Ana Margarida Barbosa (PhD)
Universidade do Minho Escola de Medicina, Portugal
2022 Regulation of pulmonary CD4+ T cell responses to Mycobacterium tuberculosis infection
(Thesis) Arguer
 Catarina Ferreira (PhD)
Universidade do Minho Escola de Medicina, Portugal
2022 The role of epithelial glycoprofile in colorectal cancer prevention
(Thesis) Main arguer
 Carolina Dantas (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 Immunesuppression during chronic lymphocytic choriomeningitis virus infection and response to unrelated Ectromelia Virus infection
(Thesis) Arguer
 Pedro Alves-Peixoto (PhD)
Universidade do Minho Escola de Medicina, Portugal
2021 The role of the innate immunity mechanisms on Tuberculosis physiopathology
(Thesis) Arguer
 Daniel Roçadas Santos Silva (Master)
Universidade do Minho Escola de Medicina, Portugal
2017 The impact of immune system’s aging on multiple sclerosis disease progression
Supervisor
 Inês Lages (Other)
Universidade do Minho Escola de Ciências, Portugal
2016 T cells during mycobacterial infections: production and activation
(Thesis) Arguer
 Palmira Barreira-Silva (PhD)
Universidade do Minho Escola de Medicina, Portugal
2016 In vitro infection of lymphoid tissues by HIV-2
(Thesis) Main arguer
 Ana Antão (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 Behavioral characterization of C57BL/6 TCR-alpha knock-out mice
(Thesis) Arguer
 João Pacheco (Master)
Universidade do Minho Escola de Medicina, Portugal
2016 Neuroinflammation in a mouse model of Machado-Joseph disease: TUDCA as an inflammatory modulator and neuroprotective agent
(Thesis) Arguer
 Gonçalo Gonçalves (Master)
Universidade do Minho Escola de Medicina, Portugal
2015 HIV infection: from the evaluation of a new diagnostic test for the tuberculosis co-infection to the immune reconstitution during antiretroviral therapy
Supervisor
 João do Canto Gomes (Other)
Universidade do Minho Escola de Ciências, Portugal
2014 The impact of CD8 T-cell selection in the establishment of thymic epithelial cell microenvironments
(Thesis) Main arguer
 Helena Xavier (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2011 Is premature thymic atrophy induced by Mycobacterium avium caused by increases thymocyte’s apoptosis
(Thesis) Main arguer
 Cláudia Martins (Master)
Universidade do Minho Escola de Ciências, Portugal
2010 Thymic infection by Mycobacterium avium: characterization of thymic dendritic cells
Supervisor
 Ângela Fernandes (Other)
Universidade do Minho Escola de Ciências, Portugal

Association member

Society Organization name Role
2022/01 - Current International Society for the Advancement of Cytometry (ISAC) Member
2021/02 - Current Iberian Society for Cytometry (SIC) Member
2003 - Current Portuguese Society for Immunology Member
2002 - 2003 Portuguese Society for Biochemistry Member

Committee member

Activity description
Role 		Institution / Organization
2016 - Current I was part of several Task Forces/discussion forums at the ICVS/School of Medicine namely: ICVS equipments and services (2023 to present); ICVS organizational model discussion (2021); Re-structuration of the Medical Degree (MED2.0) Logistics group (2019); Implementation of public consultations for acquisition of consumables (2018); Equipment acquisition (2016).
Member
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/04 - 2023/05 Reviewer for Graduate Women in Science (GWS) Fellowships. GWS is a volunteer-run organisation that supports early-career and graduate student women scientists through research funding
Advisor / Consultant
2021 - 2021 Reviewer for Graduate Women in Science (GWS) Fellowships. GWS is a volunteer-run organisation that supports early-career and graduate student women scientists through research funding Graduate Women in Science, United States

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2016 - 2023 Flow cytometry practical session (4-hours lesson). Post-graduation course in Fundamentals in Immunology. Universidade do Minho Escola de Medicina, Portugal
2014 - 2014 "T cell differentiation" (1-hour lesson) Post-graduation course in Fundamentals in Immunology Universidade do Minho Escola de Medicina, Portugal
2012 - 2014 Is T cell recirculation back to the thymus responsible for the immune response to infection in this organ? (1-hour lesson) Post-graduation course in Host-Pathogen Interaction Universidade do Minho Escola de Medicina, Portugal
2010 - 2010 Infection of the thymus by mycobacteria: Is an immune response being established in the thymus? (1-hour lesson) Post-graduation course in Host-Pathogen Interaction Universidade do Minho Escola de Medicina, Portugal
2010 - 2010 How is T cell differentiation altered by colonization of the thymus by mycobacteria? (1-hour lesson) Post-graduation course in Host-Pathogen Interaction Universidade do Minho Escola de Medicina, Portugal
2005 - 2005 Instructor of the practical module of flow cytometry at the postgraduate course (5-hours lesson) 1st Workshop on Advanced Light Microscopy and Flow Cytometry Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2018 - 2023 Frontiers in Immunology (1664-3224) Frontiers Media SA
2021 - 2021 Microorganisms (2076-2607) MDPI
2018 - 2021 BMC Immunology (1471-2172) Springer (Biomed Central Ltd.)
2020 - 2020 Scientific Reports (2045-2322) Nature

Legal proceeding

Activity description Case
2019/02/14 - 2019/08/12 Career break due to clinical risk in pregnancy (30days) followed by maternal leave (150 days according to the Portuguese Legislation).
2015/06/25 - 2015/10/22 Career break due to maternal leave (120 days according to the Portuguese Legislation).
2011/08/16 - 2011/12/13 Career break due to maternal leave (120 days according to the Portuguese Legislation).
Distinctions

Award

2017 Best poster award. XV Meeting Iberian Flow Cytometry Society. Lisbon. “Applying R automated analysis to flow cytometry data from a prospective cohort of HIV-infected patients”. R. Rb-Silva, E. Lee, C. Nobrega, A. Horta, M. Correia-Neves
Iberian Society of Cytometry (SIC), Spain
2014 Best poster award. 40th New England Immunology Conference. Boston. “Mycobacterium avium infection-induced premature thymic atrophy: knowing what is causing and unveiling how and where”. P. Barreira-Silva, et al.
The American Association of Immunologists, United States
2014 Travel grant. Short visit Gunilla Kallenius lab, at the Karolinska Institute. This visit was performed to discuss and design the strategy to test new diagnostic approach for M. tuberculosis infection. Stockholm, Sweden
Sociedade Portuguesa de Imunologia, Portugal
2012 Best poster award. Tuberculosis: from the hospital to the bench and back. Braga. “The role of re-circulating T cells in the control of the mycobacterial infection within the thymus”. B. Cerqueira-Rodrigues, C. Nobrega, P. Barreira-Silva, M. Correia-Neves
2012 Travel grant. Attend the Cell Symposia on "Human Immunology". Lisbon, Portugal
Sociedade Portuguesa de Imunologia, Portugal
2011 Travel grant. To attend the “International School of Immunology”. Tavira, Portugal
Sociedade Portuguesa de Imunologia, Portugal
2006 Honorable mention. “The effect of IL-10 activity in Mycobacterium avium infection is dependent on the host genetic background". S. Roque, C. Nobrega, R. Appelberg, M. Correia-Neves
Ricardo Jorge Award in Public Health, Portugal
2004 Travel grant (FLAD; refª 145/2004). One-month visit to Ian Orme’s Lab at Colorado State University. Forth Colins, USA.
Fundação Luso-Americana, Portugal