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Paulo Almeida graduated in Applied Chemistry - Organic Chemistry in 1987 by University of Nova de Lisboa, Portugal and in 1991 completed his PhD in Chemistry - Organic Chemistry by Universidade Nova de Lisboa. In 2008, obtained his Habilitian Title in Chemistry by the University of Beira Interior (UBI), Portugal. From 1985 to 1987 during his graduated course was a monitor at the Faculty of Sciences and Technology - University of Nova de Lisboa. From 1992 started his academic and research activities in the Faculty of Sciences - UBI as Assistant Professor (1992-2000), Associated Professor (2000-2009) and as full professor since 2009. From 2010 became an integrated member of Health Sciences Research Centre of UBI (CICS - UBI) where he was the coordinator of BBS - Biotechnology and Biomolecular Sciences of this Research Centre (2015-2017) and the coordinator of BCDR - Biomedicinal Chemistry and Drug Research group (2021). From 2009 to 2013 was vice-rector for Education and Internationalization of UBI. Since November 2017, is the Dean of the Faculty of Sciences - UBI. Paulo Almeida published 106 douments (Scopus database) including 94 articles, 6 reviews, 4 book chapters and 1 Editorial. In this database, Paulo Almeida has 1560 citations by 1037 documents, 148 co-authors an h-index of 23. He is author of 2 national patents, Paulo Almeida participated as a team member in 11 research projects, 4 of them as responsible member of the participating institution and 2 of them as principal researcher. The pedagogical capacity of Paulo Almeida is supported by recurrent teaching activities of mainly organic and medicinal chemistry at UBI. Moreover Paulo Almeida completed the supervision of 3 post-doctoral researchers, 5 PhD thesis and actually supervised 1 PhD. Additional, supervised 11 MSc dissertations and co-supervised 8. Works in the area of Medical and Health Sciences with emphasis on Basic Medicine /Medicinal Chemistry, His scientific research is mainly focus on the synthesis/organic chemistry and medicinal chemistry areas, with a special interest in the development of new drugs with biologic activity as photosensitizes for photodynamic therapy (PDT), antiproliferative, antioxidant and antimicrobial, and as inhibitors of enzimes such as xanthine oxidase, 5a-redutase, monocarboxylate transporter 4, CD-36 and cyclooxygenase-2.
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Identification

Personal identification

Full name
Paulo Jorge Silva Almeida

Citation names

  • Almeida, Paulo

Author identifiers

Ciência ID
6E18-3C6F-6842
ORCID iD
0000-0003-0110-4795
Researcher Id
S-5375-2016
Scopus Author Id
7102848111

Email addresses

  • paulo.almeida@ubi.pt (Professional)

Telephones

Telephone
  • 272329130 (Professional)
  • 275319700 Ext.: 1500 (Professional)

Addresses

  • Centro de Investigação em Ciências da Saúde (CICS-UBI), 6200-500, Covilhã, Castelo Branco, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Advanced (C1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Beginner (A1) Advanced (C1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2008/03/17 - 2008/03/18
Concluded
 Química (Título de Agregado)
Universidade da Beira Interior, Portugal
"Relatório da unidade Curricular de "Química Orgânica" da Licenciatura (1º ciclo) em Bioquímica; Lição de Síntese "Cianinas. Corantes Funcionais "" (THESIS/DISSERTATION)
 Aprovado por unanimidade
1987/10/01 - 1991/03/18
Concluded
 Química (Doutoramento)
Major in Química Orgânica
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Rearranjos de Hetero-Cope em Derivados de N-Aril-Hidroxilaminas" (THESIS/DISSERTATION)
 Distinção e Louvor por unanimdadeidade
1981/01/01 - 1987/06/01
Concluded
 Química Aplicada (Licenciatura)
Major in Química Orgânica
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Não aplicável" (THESIS/DISSERTATION)
 15 (quinze) valores
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2009/06/02 - Current Full Professor (University Teacher) Universidade da Beira Interior Faculdade de Ciências, Portugal
Universidade da Beira Interior Faculdade de Ciências, Portugal
2000/03/01 - 2009/05/31 Associate Professor (University Teacher) Universidade da Beira Interior, Portugal
Universidade da Beira Interior Faculdade de Ciências, Portugal
1992/05/02 - 2000/02/29 Assistant Professor (University Teacher) Universidade da Beira Interior, Portugal
Universidade da Beira Interior Faculdade de Ciências, Portugal
1985 - 1987 Tutor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Other Careers

Category
Host institution 		Employer
1991/05 - 1992/03/30 Técnico Superior (Técnico Superior) Controlab, Laboratório de Análises Químicas, Físicas e Biológicas Lda, , Portugal
Controlab, Laboratório de Análises Químicas, Físicas e Biológicas Lda, , Portugal
1977/10 - 1982/05 Assistente Técnico (Assistente Técnico) Fábrica Nacional de Munições das Indústrias Nacionais de Defesa E.P., Portugal
Fábrica Nacional de Munições das Indústrias Nacionais de Defesa E.P., Portugal
Projects

Contract

Designation Funders
2018/01 - 2021/06 ProMETAB - Fatores extrínsecos na modulação do metabolismo da próstata: aplicações na prevenção, diagnóstico e tratamento do cancro
National Funds by FCT - Project UID/Multi/00709/2013)
Project POCI-01-01-45-FEDER-029114
POCI-01-0145-FEDER-029114
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2010/05 - 2013/11 Affinity Interactions between Cyanine Dyes and Biomolecules in Chromatographic Processes
Provided by PTCRIS: 100896
100896
PTDC/QUI-QUI/100896/2008
Principal investigator
Universidade da Beira Interior FibEnTech Materiais Fibrosos e Tecnologias Ambientais, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2009/02 - 2013/02 Surface Photochemistry: Photochemistry and Photophysics of Near Infrared Functional Dyes on Surfaces and Nanocavities
Provided by PTCRIS: 70153
70153
PTDC/QUI/70153/2006
Researcher
Universidade da Beira Interior FibEnTech Materiais Fibrosos e Tecnologias Ambientais, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2005/09 - 2008/06 Azo Dyes for Photodynamic Therapy
Provided by PTCRIS: 57913
57913
POCI/QUI/57913/2004
Researcher
Universidade da Beira Interior FibEnTech Materiais Fibrosos e Tecnologias Ambientais, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2003 - 2006 Development of New Supports for Dye-Affinity Chromatography
POCTI/2002/QUI/44776
Researcher
Fundação para a Ciência e a Tecnologia
2000/10/01 - 2003/04/30 New cyanine photosensitizers for photodynamic therapy of cancer
Provided by PTCRIS: 32915
32915
POCTI/32915/QUI/2000
Principal investigator
Universidade de Trás-os-Montes e Alto Douro Centro de Química Vila Real, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
1994 - 2000 Desenvolvimento e Caracterização de Novos Corantes Fotográficos em Interfaces Sólidas e Emulsões
PBIC/P/QUIM/1659/93
Researcher
Universidade da Beira Interior FibEnTech Materiais Fibrosos e Tecnologias Ambientais, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
Outputs

Publications

Book chapter
  1. Brito, V.; Alves, G.; Almeida, P.; Silvestre, S.. "Oxidized steroids as 5a-reductase inhibitors with potential interest in prostatic diseases: A review". 1-35. 2022.
  2. Serrano, J.L.; Almeida, P.; Silvestre, S.M.. "Recent highlights on xanthine oxidase inhibitors: Focus on preclinical studies". 71-132. 2021.
  3. Almeida, Paulo; M. L. F. M. Pacheco; S. F. P. Friães; R. E. Boto; A. M. Silva; L. V. Reis. "Synthesis of a Squarylium Cyanine Dye as Potential Photosensitizer for Photodynamic Therapy (PDT)". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC), edited by Carlos A. M. Afonso; Nuno R. Candeias; Dulce P. Simão; Alexandre F. Trindade; Jaime A. S. Coelho; Bin Tan, 301-305. United Kingdom: The Royal Society of Chemistry, 2017.
    Published
  4. Almeida, Paulo; S. F. P. Friães; R. E. Boto; A. M. Silva; L. V. Reis. "A Free-Solvent Approach for Chalcone Synthesis via an Aldol Reaction". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC), edited by Carlos A. M. Afonso; Nuno R. Candeias; Dulce P. Simão; Alexandre F. Trindade; Jaime A. S. Coelho; Bin Tan; Robert Franzén, 339-341. Royal Society of Chemistry, 2017.
    Published
  5. Nunes, Sílvia C.; Almeida, Paulo; de Zea Bermudez, Verónica; Nunes, S.C.; Almeida, P.; de Zea Bermudez, V.. "Ordered Mesoporous Sol-Gel Materials: From Molecular Sieves to Crystal-Like Periodic Mesoporous Organosilicas". In The Sol-Gel Handbook, 575-604. Wiley-VCH Verlag GmbH & Co. KGaA, 2015.
    Published • 10.1002/9783527670819.ch18
Conference paper
  1. Marina Cassago Posso; João Lourenço Serrano; Paulo Almeida; Fernanda Domingues; Samuel Silvestre; Susana Ferreira. "New Fluoroquinolone–Phenothiazine Hybrids and Their Antimicrobial Activity". 2022.
    10.3390/eca2022-12722
Journal article
  1. Vanessa Brito; Mariana Marques; Marta Esteves; Catarina Serra-Almeida; Gilberto Alves; Paulo Almeida; Liliana Bernardino; Samuel Silvestre. "Synthesis, In Vitro Biological Evaluation of Antiproliferative and Neuroprotective Effects and In Silico Studies of Novel 16E-Arylidene-5a,6a-epoxyepiandrosterone Derivatives". Biomedicines (2023): https://doi.org/10.3390/biomedicines11030812.
    10.3390/biomedicines11030812
  2. Lima, E.; Barroso, A.G.; Ferreira, O.; Boto, R.E.; Fernandes, J.R.; Almeida, P.; Silvestre, S.M.; Santos, A.O.; Reis, L.V.. "Benz[e]indole-bearing aminosquaraine dyes: Which of the amines introduced into the squaric ring will be able to induce the best in vitro photodynamic effect?". Dyes and Pigments 215 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85151466440&partnerID=MN8TOARS.
    10.1016/j.dyepig.2023.111239
  3. Gomes, V.S.D.; Ferreira, J.C.C.; Boto, R.E.; Almeida, P.; Fernandes, J.R.; Sousa, M.J.; Reis, L.V.; Gonçalves, M.S.T.. "Evaluation of Antifungal Activity and Potential Application as Fluorescent Probes of Indolenine and Benzo[e]Indole-Based Squarylium Dyes". Photochemistry and Photobiology 99 5 (2023): 1282-1292. http://www.scopus.com/inward/record.url?eid=2-s2.0-85145500445&partnerID=MN8TOARS.
    10.1111/php.13762
  4. Bifari, E.N.; Almeida, P.; El-Shishtawy, R.M.. "Advancing panchromatic effect for efficient sensitization of cyanine and hemicyanine-based dye-sensitized solar cells". Materials Today Energy 36 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85161993375&partnerID=MN8TOARS.
    10.1016/j.mtener.2023.101337
  5. Vanessa Brito; Adriana Oliveira Santos; Gilberto Alves; Paulo Almeida; Samuel Silvestre. "Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies". Molecules (2022): https://doi.org/10.3390/molecules27186126.
    10.3390/molecules27186126
  6. João L. Serrano; Ana Maia; Adriana O. Santos; Eurico Lima; Lucinda V. Reis; Maria J. Nunes; Renato E. F. Boto; Samuel Silvestre; Paulo Almeida. "An Insight into Symmetrical Cyanine Dyes as Promising Selective Antiproliferative Agents in Caco-2 Colorectal Cancer Cells". Molecules (2022): https://doi.org/10.3390/molecules27185779.
    10.3390/molecules27185779
  7. Margarida A. Sousa; Eurico Lima; Octávio Ferreira; Renato E. Boto; Paulo Almeida; Lucinda V. Reis. "In Vitro and In Silico Evaluation of Indole-Bearing Squaraine Dyes as Potential Human Serum Albumin Fluorescent Probes". Chemosensors (2022): https://doi.org/10.3390/chemosensors10080314.
    10.3390/chemosensors10080314
  8. "Squaraine Dyes Derived from Indolenine and Benzo[ e ]indole as Potential Fluorescent Probes for HSA Detection and Antifungal Agents". Photochemistry and Photobiology (2022): http://dx.doi.org/10.1111/php.13624.
    10.1111/php.13624
  9. Lima, E.; Barroso, A.G.; Sousa, M.A.; Ferreira, O.; Boto, R.E.; Fernandes, J.R.; Almeida, P.; et al. "Picolylamine-functionalized benz[e]indole squaraine dyes: Synthetic approach, characterization and in vitro efficacy as potential anticancer phototherapeutic agents". European Journal of Medicinal Chemistry 229 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85121982398&partnerID=MN8TOARS.
    10.1016/j.ejmech.2021.114071
  10. João L. Serrano; Diana Lopes; Melani J. A. Reis; Renato E. F. Boto; Samuel Silvestre; Paulo Almeida. "Bis-thiobarbiturates as Promising Xanthine Oxidase Inhibitors: Synthesis and Biological Evaluation". Biomedicines 9 10 (2021): 1443-1443. https://doi.org/10.3390/biomedicines9101443.
    10.3390/biomedicines9101443
  11. Brito, V.; Alves, G.; Almeida, P.; Silvestre, S.. "Highlights on steroidal arylidene derivatives as a source of pharmacologically active compounds: A review". Molecules 26 7 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105142025&partnerID=MN8TOARS.
    10.3390/molecules26072032
  12. S.D. Gomes, V.; E.F. Boto, R.; Almeida, P.; J.G. Coutinho, P.; Rui Pereira, M.; Sameiro T. Gonçalves, M.; V. Reis, L.. "Squaraine dyes as serum albumins probes: Synthesis, photophysical experiments and molecular docking studies". Bioorganic Chemistry 115 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85111936602&partnerID=MN8TOARS.
    10.1016/j.bioorg.2021.105221
  13. Vanessa S.D. Gomes; Helena M.R. Gonçalves; Renato E.F. Boto; Paulo Almeida; Lucinda V. Reis. "Barbiturate squaraine dyes as fluorescent probes for serum albumins detection". Journal of Photochemistry and Photobiology A: Chemistry 400 (2020): 112710-112710. https://doi.org/10.1016/j.jphotochem.2020.112710.
    10.1016/j.jphotochem.2020.112710
  14. Eurico Lima; Renato Boto; Diana Ferreira; José Ramiro Afonso Fernandes; Paulo Almeida; L.F. Vieira Ferreira; Souto, E.B.; Amélia M Silva; Lucinda V. Reis. "Quinoline- and Benzoselenazole-Derived Unsymmetrical Squaraine Cyanine Dyes: Design, Synthesis, Photophysicochemical Features and Light-Triggerable Antiproliferative Effects against Breast Cancer Cell Lines". Materials (2020): https://www.mdpi.com/1996-1944/13/11/2646.
    10.3390/ma13112646
  15. Pedro F. Soeiro; João L. Serrano; José A. Paixão; Renato E. F. Boto; Samuel Silvestre; Paulo Almeida. "The Synthesis of 2-Spiroindolin-3-one-(thio)barbiturates from 2,1-Benzisoxazoles: A Rearrangement Promoted by Thermal Conditions". Synthesis (2020): https://doi.org/10.1055/s-0039-1690865.
    10.1055/s-0039-1690865
  16. Lima, E.; Ferreira, O.; Silva, J.F.; Santos, A.O.; Boto, R.E.; Fernandes, J.R.; Almeida, P.; Silvestre, S.M.; Reis, L.V.. "Photodynamic activity of indolenine-based aminosquaraine cyanine dyes: Synthesis and in vitro photobiological evaluation". Dyes and Pigments 174 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075425313&partnerID=MN8TOARS.
    10.1016/j.dyepig.2019.108024
  17. Serrano, J.L.; Figueiredo, J.; Almeida, P.; Silvestre, S.. "From Xanthine Oxidase Inhibition to in Vivo Hypouricemic Effect: An Integrated Overview of in Vitro and in Vivo Studies with Focus on Natural Molecules and Analogues". Evidence-based Complementary and Alternative Medicine 2020 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85081248577&partnerID=MN8TOARS.
    10.1155/2020/9531725
  18. Nunes, S.C.; Fernandes, M.; Gonçalves, H.M.R.; Serrano, J.L.; Almeida, P.; Bermudez, V.Z.. "Di-urea cross-linked siloxane hybrid materials incorporating oligo(oxypropylene) and oligo(oxyethylene) chains". Journal of Sol-Gel Science and Technology 95 3 (2020): 620-634. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083891092&partnerID=MN8TOARS.
    10.1007/s10971-020-05272-5
  19. Martins, T.D.; Lima, E.; Boto, R.E.; Ferreira, D.; Fernandes, J.R.; Almeida, P.; Ferreira, L.F.V.; Silva, A.M.; Reis, L.V.. "Red and near-infrared absorbing dicyanomethylene squaraine cyanine dyes: Photophysicochemical properties and anti-tumor photosensitizing effects". Materials 13 9 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85085257117&partnerID=MN8TOARS.
    10.3390/ma13092083
  20. Silvestre, S.M.; Almeida, P.J.S.; El-Shishtawy, R.. "Natural Products as a Source for New Leads in Gout Treatment". Evidence-based Complementary and Alternative Medicine 2020 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85085574466&partnerID=MN8TOARS.
    10.1155/2020/8274975
  21. Fernandes, T.C.D.; Lima, E.; Boto, R.E.; Ferreira, D.; Fernandes, J.R.; Almeida, P.; Ferreira, L.F.V.; Silva, A.M.; Reis, L.V.. "In vitro phototherapeutic effects of indolenine-based mono- and dithiosquaraine cyanine dyes against Caco-2 and HepG2¿human cancer cell lines". Photodiagnosis and Photodynamic Therapy 31 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85085948160&partnerID=MN8TOARS.
    10.1016/j.pdpdt.2020.101844
  22. Lima, Eurico; Ferreira, Octávio; Gomes, Vanessa S.D.; Santos, Adriana O.; Boto, Renato E.; Fernandes, José R.; Almeida, Paulo; Silvestre, Samuel M.; Reis, Lucinda V.. "Synthesis and in vitro evaluation of the antitumoral phototherapeutic potential of squaraine cyanine dyes derived from indolenine". Dyes and Pigments 167 (2019): 98-108. http://dx.doi.org/10.1016/j.dyepig.2019.04.007.
    10.1016/j.dyepig.2019.04.007
  23. Almeida, Paulo. "Nimesulide analogues: From anti-inflammatory to antitumor agents". (2019): http://dx.doi.org/10.1016/j.bioorg.2019.102966.
    10.1016/j.bioorg.2019.102966
  24. João L. Serrano; Pedro F. Soeiro; Melani A. Reis; Renato E. F. Boto; Samuel Silvestre; Paulo Almeida. "Synthesis and process optimization of symmetric and unsymmetric barbiturates C5-coupled with 2,1-benzisoxazoles". Molecular Diversity (2019): https://doi.org/10.1007/s11030-019-09937-4.
    10.1007/s11030-019-09937-4
  25. Vanessa Brito; Adriana O. Santos; Paulo Almeida; Samuel Silvestre. "Novel 4-azaandrostenes as prostate cancer cell growth inhibitors: Synthesis, antiproliferative effects, and molecular docking studies". Comptes Rendus Chimie (2019): https://doi.org/10.1016/j.crci.2018.07.011.
    10.1016/j.crci.2018.07.011
  26. Nunes, S.C.; Saraiva, S.M.; Pereira, R.F.P.; Silva, M.M.; Carlos, L.D.; Almeida, P.; Gonçalves, M.C.; Ferreira, R.A.S.; De Zea Bermudez, V.. "Luminescent ¿-carrageenan-based electrolytes containing neodymium triflate". Molecules 24 6 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85062999386&partnerID=MN8TOARS.
    10.3390/molecules24061020
  27. Figueiredo, J.; Serrano, J.L.; Soares, M.; Ferreira, S.; Domingues, F.C.; Almeida, P.; Silvestre, S.. "5-Hydrazinylethylidenepyrimidines effective against multidrug-resistant Acinetobacter baumannii: Synthesis and in vitro biological evaluation of antibacterial, radical scavenging and cytotoxic activities". European Journal of Pharmaceutical Sciences 137 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85067897898&partnerID=MN8TOARS.
    10.1016/j.ejps.2019.104964
  28. Tiago Santos; Andreia Brito; Renato Boto; Pedro Sousa; Paulo Almeida; Carla Cruz; Cândida Tomaz. "Influenza DNA vaccine purification using pHEMA cryogel support". Separation and Purification Technology 206 (2018): 192-198. https://doi.org/10.1016/j.seppur.2018.06.002.
    10.1016/j.seppur.2018.06.002
  29. Figueiredo, J.; Serrano, J.L.; Cavalheiro, E.; Keurulainen, L.; Yli-Kauhaluoma, J.; Moreira, V.M.; Ferreira, S.; et al. "Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents". European Journal of Medicinal Chemistry 143 (2018): 829-842. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037347492&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.11.070
  30. Tiago D. Martins; Marlene L. Pacheco; Renato E. Boto; Paulo Almeida; José Paulo S. Farinha; Lucinda V. Reis. "Synthesis, characterization and protein-association of dicyanomethylene squaraine dyes". Dyes and Pigments 147 (2017): 120-129. https://doi.org/10.1016/j.dyepig.2017.07.070.
    10.1016/j.dyepig.2017.07.070
  31. João L. Serrano; Eunice Cavalheiro; Sónia Barroso; Maria J. Romão; Samuel Silvestre; Paulo Almeida. "A synthetic route to novel 3-substituted-2,1-benzisoxazoles from 5-(2-nitrobenzylidene)(thio)barbiturates". Comptes Rendus Chimie 20 11-12 (2017): 990-995. https://doi.org/10.1016/j.crci.2017.10.002.
    10.1016/j.crci.2017.10.002
  32. Sofia Friães; Amélia M. Silva; Renato E. Boto; Diana Ferreira; José R. Fernandes; Eliana B. Souto; Paulo Almeida; Luis F. Vieira Ferreira; Lucinda V. Reis. "Synthesis, spectroscopic characterization and biological evaluation of unsymmetrical aminosquarylium cyanine dyes". Bioorganic & Medicinal Chemistry (2017): https://doi.org/10.1016%2Fj.bmc.2017.05.022.
    10.1016/j.bmc.2017.05.022
  33. Nunes, S. C.; Toquer, G.; Cardoso, M. A.; Mayoral, A.; Ferreira, R. A. S.; Carlos, L. D.; Ferreira, P.; et al. "Structuring of Alkyl-Triazole Bridged Silsesquioxanes". Chemistryselect 2 1 (2017): 432-442. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000395434600061&KeyUID=WOS:000395434600061.
    10.1002/slct.201601806
  34. Catarro, M.; Serrano, J.; Cavalheiro, E.; Ramos, S.; Santos, A.O.; Silvestre, S.; Almeida, P.. "Novel 4-acetamide-2-alkylthio-N-acetanilides resembling nimesulide: Synthesis, cell viability evaluation and in silico studies". Bioorganic and Medicinal Chemistry 25 16 (2017): 4304-4313. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021808666&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.06.009
  35. Nunes, S.C.; Pereira, R.F.P.; Sousa, N.; Silva, M.M.; Almeida, P.; Figueiredo, F.M.L.; de Zea Bermudez, V.. "Eco-Friendly Red Seaweed-Derived Electrolytes for Electrochemical Devices". Advanced Sustainable Systems 1 9 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85063143835&partnerID=MN8TOARS.
    10.1002/adsu.201700070
  36. Nunes, S.C.; Bürglová, K.; Hodacová, J.; Ferreira, R.A.S.; Carlos, L.D.; Almeida, P.; Cattoën, X.; Wong Chi Man, M.; De Zea Bermudez, V.. "Nanostructuring of bridged organosilane precursors with pendant Alkyl chains". European Journal of Inorganic Chemistry 2015 7 (2015): 1218-1225. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923927365&partnerID=MN8TOARS.
    10.1002/ejic.201402673
  37. Nunes, S.C.; Hümmer, J.; Freitas, V.T.; Ferreira, R.A.S.; Carlos, L.D.; Almeida, P.; De Zea Bermudez, V.. "Erratum: Di-amidosils with tunable structure, morphology and emission quantum yield: The role of hydrogen bonding (Journal of Materials Chemistry C (2015) 3 (6844-6861))". Journal of Materials Chemistry C 3 31 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84938384963&partnerID=MN8TOARS.
    10.1039/c5tc90133b
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  94. Pardal, AC; Ramos, SS; Santos, PF; Reis, LV; Almeida, P; Pardal, A.C.; Ramos, S.S.; et al. "Synthesis and spectroscopic characterisation of N-alkyl quaternary ammonium salts typical precursors of cyanines". Molecules 7 3 (2002): 320-330. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000174849300001&KeyUID=WOS:000174849300001.
    10.3390/70300320
  95. Santos, P.F.; Almeida, P.S.; Lobo, A.M.; Prabhakar, S.; Santos, PF; Almeida, PS; Lobo, AM; Prabhakar, S. "A formal synthesis of (±)-eseroline via an azaoxy-cope rearrangement". Heterocycles 55 6 (2001): 1029-1043. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035362609&partnerID=MN8TOARS.
  96. Boto, R.E.F.; Oliveira, A.S.; Vieira Ferreira, L.F.; Almeida, P.. "Study of N,N'-dicarboxyalkylthiacarbocyanines as cyanine direactive dyes covalently bound to cellulose". Dyes and Pigments 48 2 (2001): 71-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035241976&partnerID=MN8TOARS.
    10.1016/S0143-7208(00)00094-2
  97. Ramos, S.S.; Vilhena, A.F.; Santos, L.; Almeida, P.; Ramos, SS; Vilhena, AF; Santos, L; Almeida, P. "1H and 13C NMR spectra of commercial rhodamine ester derivatives". Magnetic Resonance in Chemistry 38 6 (2000): 475-478. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034196402&partnerID=MN8TOARS.
    10.1002/1097-458X(200006)38:6<475::AID-MRC662>3.0.CO;2-X
  98. Oliveira, A.S.; Almeida, P.; Ferreira, L.F.V.; Oliveira, AS; Almeida, P; Ferreira, LFV. "Photophysics of cyanine dyes on surfaces: Laser-induced photoisomer emission of 3,3'-dialkylthiacarbocyanines adsorbed on microcrystalline cellulose". Collection of Czechoslovak Chemical Communications 64 3 (1999): 459-473. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033473112&partnerID=MN8TOARS.
    10.1135/cccc19990459
  99. Almeida, Paulo. "Cianinas, a Cor não Visível da Fotografia". Química - Boletim da SPQ - ... a Cor 73 (1999): 9-12. https://www.spq.pt/magazines/BSPQuimica/597/article/3000884/pdf.
    Published
  100. Ferreira, LFV; Cabral, PV; Almeida, P; Oliveira, AS; Reis, MJ; do Rego, AMB; Vieira Ferreira, L.F.; et al. "Ultraviolet visible absorption, luminescence, and X-ray photoelectron spectroscopic studies of a rhodamine dye covalently bound to microcrystalline cellulose". Macromolecules 31 12 (1998): 3936-3944. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000074343700024&KeyUID=WOS:000074343700024.
    10.1021/MA971726R
  101. Almeida, P.S.; Prabhakar, S.; Lobo, A.M.; Marcelo-Curlo, M.J.. "Synthetic applications of N-Aryl-O-acyl hydroxymic acids. A convenient route to 3-substituted N-Benzoyl oxindoles". Tetrahedron Letters 32 23 (1991): 2671-2674. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000489754&partnerID=MN8TOARS.
    10.1016/S0040-4039(00)78815-0
  102. "A Novel Synthesis of Benzimidazolinones". Heterocycles (1989): https://publons.com/wos-op/publon/9543555/.
    10.3987/COM-88-S103

Intellectual property

Patent
  1. Almeida, Paulo. 2021. "Bis-pirimidinonas como inibidores da Xantina Oxidase para o tratamento de condições patológicas causadas por hiperuricemia". Portugal.
    Granted/Issued
  2. Almeida, Paulo; C. Cruz; E. Cairrão; L. Breitenfeld; J. A. Queiroz. 2012. "Método para a marcação da mitocôndria e do retículo endoplasmático utilizando compostos macrocíclicos fluorescentes". Portugal.
    Granted/Issued

Other

Other output
  1. Synthesis and fixation of aminocyanines to microcrystalline cellulose using cyanuric chloride as a cross-linking agent. Coloration Technology. 2001. Pardal, A.C.; Ramos, S.S.; Santos, L.; Almeida, P.; Pardal, AC; Ramos, SS; Santos, L; Almeida, P. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035020080&partnerID=MN8TOARS.
    10.1111/j.1478-4408.2001.tb00334.x
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018 - 2024 Desenvolvimento de novos anticancerígenos: combinação de ácidos barbitúricos e tiobarbitúricos com fármacos antitumorais
Supervisor
 Química (PhD)
Universidade da Beira Interior, Portugal
2017 - 2023/06/04 New steroidal arylidene derivatives potentially useful in the treatment of prostatic diseases
Supervisor of Vanessa Sofia Figueiredo de Brito
 Química (PhD)
Universidade da Beira Interior, Portugal
2018 - 2019 Desenvolvimento de novos bis-tiobarbituratos como potenciais inibidores da Xantina Oxidase. Experiência profissionalizante na vertente de Farmácia Comunitária e Investigação
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2017 - 2018 Novos derivados espiroindolin-3-ona(tio) barbituratos com potencial atividade antimalárica.
Supervisor
 Química Medicinal (Master)
Universidade da Beira Interior, Portugal
2017 - 2018 Uma nova via sintética para N-óxidos de quinolina. Caracterização estrutural e avaliação biológica
Supervisor
 Química Medicinal (Master)
Universidade da Beira Interior, Portugal
2017 - 2018 A Microwave Assisted Optimization of New Spiroindolin-3-one(thio)barbiturates Synthesis, biological and computational evaluation
Co-supervisor of Pedro António Fantini Soeiro
 Química Medicinal (Master)
Universidade da Beira Interior, Portugal
2015 - 2016 Desenvolvimento de criogéis funcionalizados com barbituratos para a purificação de uma vacina de DNA plasmídico contra o Influenza
Supervisor
 Biotecnologia (Master)
Universidade da Beira Interior, Portugal
2015 - 2016 Development of new aromatase inhibitors analogues of letrozole: perspectives for treatment of male infertility
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2015 - 2016 Novos espiro(tio)barbituratos: Síntese, caracterização estrutural e avaliação biológica
Supervisor
 Química Medicinal (Master)
Universidade da Beira Interior, Portugal
2015 - 2016 Docking, síntese e avaliação citotóxica de novos análogos da nimesulida como potenciais agentes anticancerígenos
Supervisor
 Química Medicinal (Master)
Universidade da Beira Interior, Portugal
2015 - 2016 Desenvolvimento de heterociclos pirimidínicos como potenciais inibidores da xantina oxidase
Co-supervisor
 Química Medicinal (Master)
Universidade da Beira Interior, Portugal
2014 - 2015 Funcionalização de criogéis para purificação cromatográfica de DNA plasmídico
Co-supervisor
 Biotecnologia (Master)
Universidade da Beira Interior, Portugal
2013 - 2014 Desenvolvimento de Novos Suportes Cromatográficos Derivatizados com Sais Quaternários de Benzotiazole
Co-supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2012 - 2013 Síntese de Corantes Esquarílicos para Cromatografia de Afinidade de Biomoléculas
Co-supervisor
 Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2009 - 2013 Novas Abordagens na Purificação de Dna Plasmídico por Cromatografia de Afinidade Usando Ligandos Naturais
Supervisor
 Química (PhD)
Universidade da Beira Interior, Portugal
2009 - 2010 Utilização de Polímeros para a Produção de Painéis de Madeira de Baixa Densidade
Supervisor
 Química Industrial (Master)
Universidade da Beira Interior, Portugal
2007 - 2008 Síntese de novos Azobenzotiazóis a partir dos respetivos Sintões Nitrosos
Supervisor
 Química Industrial (Master)
Universidade da Beira Interior, Portugal
2004 - 2007 Synthesis and Characterization of Carboxycarbocyanines and Their Application as Ligands in Dye-affinity Chromatography for Protein Purification
Supervisor
 Química (PhD)
Universidade da Beira Interior, Portugal
2003 - 2007 Desenvolvimento de Cianinas Funcionalizadas para Aplicação em Cromatografia de Afinidade
Supervisor
 Química (PhD)
Universidade da Beira Interior, Portugal
2003 - 2006 Funcionalização de Carbonos Inativados em Terpenos e Estudos Preliminares de Relação Estrutura-Atividade
Co-supervisor of Susana Sofia Ramos
 Química (PhD)
Universidade da Beira Interior, Portugal
2002 - 2003 Síntese e Propriedades Fotocrómicas de Novos 2H-Cromenos
Co-supervisor
 Química (pré-Bolonha) (Master)
Universidade da Beira Interior, Portugal
2000 - 2001 Cianinas como Ligandos para a Purificação de Proteínas por Cromatografia de Afinidade
Supervisor
 Química (pré-Bolonha) (Master)
Universidade da Beira Interior, Portugal
2000 - 2001 Heptametinocianinas Rigidificadas como Potenciais Sensibilizadores para a Fototerapia Dinâmica.
Supervisor
 Química (pré-Bolonha) (Master)
Universidade da Beira Interior, Portugal
1999 - 2000 Estudo sobre a Utilização do Cardo como Matéria-prima para a Produção de Pastas Papeleiras
Co-supervisor
 Química (pré-Bolonha) (Master)
Universidade da Beira Interior, Portugal
Distinctions

Award

2009 Prémio de Mérito Científico na área das Ciências Exactas - Química / Prize of Scientific Merit in the area of Exact Sciences - Chemistry
Banco Santander Totta, Portugal

Universidade da Beira Interior Faculdade de Ciências, Portugal