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I have a bachelor's degree in Pharmacy from the Universidade Federal do Paraná (UFPR), Brazil (2018), recognized by the Universidade de Lisboa in 2022 with a final grade of 16/20, and a Master's degree (2022) in Medicinal and Biopharmaceutical Chemistry from the Faculdade de Farmácia da Universidade de Lisboa (FFUL) with a final average grade of 18/20. My Master thesis work was evaluated with a 20/20 grade. My bachelor's degree started in 2014 and marked the beginning of my scientific career and path. During this degree, I was involved in a pharmaceutical synthesis project named "Desenvolvimento de glicoconjugados interferentes da interação célula-vírus". In this context, I had the pleasure to present a few results of this project at the 25th EVINCI (Evento de Iniciação Científica) during the 9th SIEPE (Semana de Ensino, Pesquisa e Extensão) of UFPR. I also took part in professional internships in two different pharmacies (compounding and community) and in the manufacturing section of the pharmaceutical industry. After graduation from UFPR, I worked in a community pharmacy and in the pharmaceutical industry doing quality control, where I had the resources to grow as a pharmacist and chemist. In 2020, I decided to come back into the academic world, so I applied for a Master's degree in Medicinal and Biopharmaceutical Chemistry (FFUL) where I had the opportunity to improve my skills through hands-on approaches and deepen my knowledge of structural, chemical, and biological properties of DNA and quadruplex structures. I also deepened my experience in organic synthesis and computational chemistry. Through my thesis project, I sharpened my skills in computational and organic chemistry, scientific reviewing and writing, and project management. I extended my abilities in synthesis with Dr. A. Paulo and was granted the chance to dive into computational biophysics through the work performed in Dr. Bruno L. Victor's Lab. My collaboration with Dr. Victor also provided me the opportunity to learn more about computational techniques such as Molecular Dynamics through a paid investigation grant for a project named "PAINSpot: Deal with PAINS: strategies to identify membrane modulators". Furthermore, during my master's thesis year, I presented several posters explaining my thesis work at national and international conferences. I was the first author of a paper titled "G-Quadruplexes in c-MYC Promoter as Targets for Cancer Therapy" in Biomedicines (IF: 4.8, https://doi.org/10.3390/biomedicines11030969). Through this paper, I advanced as a scientific writer and reviewer and expanded my knowledge of the intricacies of G4 as targets. Moreover, I co-authored two other papers, one titled "Major Achievements in the Design of Quadruplex-Interactive Small Molecules" in Pharmaceuticals (IF: 4.9, https://doi.org/10.3390/ph15030300) and one in Bioorganic & Medicinal Chemistry Letters titled "Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands" (IF: 2.8, 10.1016/j.bmcl.2022.128862). I attended the 3D-BioInfo-PT Annual Meeting and the Virtual Winter School on Computational Chemistry, where I had the opportunity to present my thesis work as a selected speaker. Currently, I am working with pyrrolo(4,3,2-de)quinolinone in the project entitled "Tuning the balance between the affinity and selectivity in DNA-G4-targeting molecules using a multidisciplinary approach" with FCT grant number 2023.01798.BD.
Identification

Personal identification

Full name
Bárbara Bahls Bruni

Citation names

  • Bahls, Bárbara

Author identifiers

Ciência ID
6F1E-E53E-C41D
ORCID iD
0000-0001-6011-071X
Researcher Id
AAB-6138-2022
Scopus Author Id
57611555600

Telephones

Mobile phone
  • 913111276 (Personal)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Computer and Information Sciences - Bioinformatics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Upper intermediate (B2) Proficiency (C2) Advanced (C1)
Italian Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1) Upper intermediate (B2)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2023/09/01 - 2027/08/31
Ongoing
Farmácia (Doutoramento)
Major in Química Farmacêutica e Terapêutica
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
"Tuning the balance between the affinity and selectivity in DNA-G4-targeting molecules using a multidisciplinary approach" (THESIS/DISSERTATION)
2020/09/28 - 2022/10/31
Concluded
Mestrado em Química Medicinal e Biofarmacêutica (Mestrado)
Universidade de Lisboa, Portugal
"Computer-Assisted Design and Synthesis of DNA-G4/Helicase Interaction Inhibitors" (THESIS/DISSERTATION)
2014/02/15 - 2018/12/21
Concluded
Farmácia (Bachelor)
Universidade Federal do Paraná, Brazil
"OTIMIZAÇÃO DA SÍNTESE DO METIL-BETA-GALACTOPIRANOSÍDEO" (THESIS/DISSERTATION)
Affiliation

Other Careers

Category
Host institution
Employer
2019/11/15 - 2020/09/10 Assistente (Técnico Superior de Saúde - Farmácia) Prati-Donaduzzi Medicamentos Genéricos, Brazil
2019/04/01 - 2019/10/31 Assessor (Farmacêutica) RaiaDrogasil S.A., Brazil

Others

Category
Host institution
Employer
2023/09/01 - Current Bolseiro de Doutoramento Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
(...)
Projects

Grant

Designation Funders
2023/09/01 - 2027/08/31 Tuning the balance between the affinity and selectivity in DNA-G4-targeting molecules using a multidisciplinary approach
2023.01798.BD
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/03/01 - 2017/07/31 Desenvolvimento de gliconjugados interferentes da interação célula-vírus
2010024264
Bachelor Student Fellow
Universidade Federal do Paraná, Brazil
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Concluded

Contract

Designation Funders
2023/12/04 - Current Inquiring the druggability of DNAG4-helicase interactions with small molecules
2022.06099.PTDC
Investigator
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing

Other

Designation Funders
2022/03/01 - 2022/09/30 PAINSpot: Deal with PAINS: strategies to identify membrane modulators
PTDC/BIA-BFS/28419/2017
Master Student Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Bahls, Bárbara; Israa M Aljnadi; Alexandra Paulo; Bruno L. Victor. "COMPUTER-ASSISTED DESIGN OF INDOLOISOQUINOLINES AS POTENTIAL NEW ANTICANCER DRUGS". Paper presented in CQUL 5th Meeting - Forging Bonds, Lisbon, 2022.
Conference poster
  1. Bahls, Bárbara; Paulo, Alexandra; Costa, Paulo Jorge Ferreira de Matos. Corresponding author: Bahls, Bárbara. "Design and Synthesis of Novel Pyrrolo[4,3,2-De]Quinolinones as G4 Ligands". Paper presented in iMed conference, 2024.
  2. Paulo, Alexandra; Aljnadi, Israa; Bahls, Bárbara; Mendes, Eduarda; Maçôas, Ermelinda Maria Sengo; Victor, Bruno; Russel, Rick. Corresponding author: Paulo, Alexandra. "New indolo[3,2-c]isoquinolines to target c-MYC G4 – DHX36 helicase interaction". Paper presented in 9th EuChemS, 2024.
  3. Bahls, Bárbara; Aljnadi, Israa; Emídio, Rita; Victor, Bruno; Cruz, Carla; Figueiredo, Joana; Maçôas, Ermelinda Maria Sengo; Russell, Rick; Paulo, Alexandra. Corresponding author: Bahls, Bárbara. "Design, synthesis and evaluation of new small molecules to target c-MYC G4-DHX36 helicase interaction". Paper presented in 20th RSC Nucleic Acids, 2024.
  4. Bahls, Bárbara; Emídio, Rita; Victor, Bruno; Cruz, Carla; Figueiredo, Joana; Paulo, Alexandra. Corresponding author: Bahls, Bárbara. "c-MYC G-quadruplex stabilization by 5-amino-8-chloro-11H-indolo[3,2-c]isoquinoline derivatives: in vitro and in silico studies.". Paper presented in 15th ENQO & 8th ENQT, 2024.
  5. Bahls, Bárbara; Paulo, Alexandra; Costa, Paulo Jorge Ferreira de Matos. Corresponding author: Bahls, Bárbara. "Pyrrolo[4,3,2-de]quinolinones as DNA-G4 targeting molecules". Paper presented in 2nd Annual Meeting: December 18th 2023 at UCoimbra, 2023.
  6. Emídio, Rita; Paulo, Alexandra; Victor, Bruno. "Molecular docking and synthesis of indoloisoquinoline bioisosters as new cancer therapeutics". Paper presented in 3D-BioInfo-PT Annual Meeting, 2022.
  7. Bahls, Bárbara; Paulo, Alexandra; Victor, Bruno. "Identification, design and synthesis of novel indoloisoquinolines inhibitors of c-myc:G4-helicase interaction". Paper presented in 2nd Chem&BioChem - Universidade de Lisboa, 2022.
  8. Bahls, Bárbara; Paulo, Alexandra; Victor, Bruno. "Computer-assisted design of insoloisoquinolines as potential new anticancer drugs". Paper presented in 5MCQUL, 2022.
  9. Bahls, Bárbara; Paulo, Alexandra; Victor, Bruno. "Development of c-MYC:G4-helicase interaction inhibitors". Paper presented in 5th Imed Meeting, 2022.
  10. Bahls, Bárbara; Bruno L. Victor; Paulo, Alexandra. "Computer-assisted design of indoloisoquinolines as potential DNAG4-Helicase interaction inhibitors". Paper presented in Jornadas Científicas da Universidade de Lisboa, Faculdade de Farmacia, 2022.
  11. Bahls, Bárbara; Paulo, Alexandra; Victor, Bruno. "Computer-assisted design of indoloisoquinoline as potential DNAG4-Helicase interaction inhibitors". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  12. Bahls, Bárbara; Victor, Bruno; Paulo, Alexandra. Corresponding author: Bahls, Bárbara. "Design of Indoloisoquinoline derivatives as potential inhibitors of the interaction between c-MYC:G4 and helicase". Paper presented in EJIBCE, 2021.
    https://doi.org/10.3390/mol2net-07-12112
Journal article
  1. Bahls, Bárbara; Aljnadi, Israa M.; Emídio, Rita; Mendes, Eduarda; Paulo, Alexandra. "G-Quadruplexes in c-MYC Promoter as Targets for Cancer Therapy". Biomedicines 11 3 (2023): 969. https://doi.org/10.3390/biomedicines11030969.
    Open access • 10.3390/biomedicines11030969
  2. Mendes, Eduarda; Bahls, Bárbara; Aljnadi, Israa M.; Paulo, Alexandra. "Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands". Bioorganic & Medicinal Chemistry Letters 72 (2022): 128862. http://dx.doi.org/10.1016/j.bmcl.2022.128862.
    Published • 10.1016/j.bmcl.2022.128862
  3. Mendes, Eduarda; Aljnadi, Israa M.; Bahls, Bárbara; Victor, Bruno L.; Paulo, Alexandra. "Major Achievements in the Design of Quadruplex-Interactive Small Molecules". Pharmaceuticals 15 3 (2022): 300. http://dx.doi.org/10.3390/ph15030300.
    10.3390/ph15030300
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/02/08 Design, synthesis and evaluation of c-MYC G4 stabilizers. Virtual Winter School on Computational Chemistry
Centre Européen de Calcul Atomique et Moléculaire
2022/12/22 Design and virtual screening of indoloisoquinoline derivatives as c-MYC G4 binders. 3D-BioInfo-PT Annual Meeting
ITQB (Oeiras, Portugal)
2017/10/06 Síntese de Glicoconjugados Porfirínicos Utilizando Derivados Isotiocianato. 25th EVINCI
Universidade Federal do Paraná (Curitiba, Brazil)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2024/04/12 - 2024/04/12 Advanced workshop in Computational Biophysics 3D-BioInfo-PT Avanced Workshop
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
2024/02/19 - 2024/02/23 Participation in G-Quadruplexes as INnovative ThERApeutiC Targets winter school. INTERACTION WINS 2024 VIRTUAL WINTER SCHOOL
2023/02/28 - 2023/02/28 Webinar on Successful Stories of Women in Science: Inspiring Career Paths.
Conference
European Federation for Medicinal Chemistry, Belgium
2022/12/19 - 2022/12/20 Intermediate Workshop on Computational Chemistry
Workshop
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/12/21 - 2021/12/22 Workshop in Computational Structural Biology Tools.
Workshop
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal