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Diana Sousa is a first year PhD student in the PhD Programme in Experimental Biology and Biomedicine (PDBEB) at the University of Coimbra. She got her BSc degree in Biochemistry in 2020 at the University of Coimbra. Diana concluded her master in Cellular and Molecular Biology at the University of Coimbra in 2022. In 2023, she was a research fellow at the NeuroEndocrinology of Obesity Laboratory at Coimbra Institute for Clinical and Biomedical Research (iCBR - CIBB) at the University of Coimbra, where she work with adipose tissue dopaminergic signalling in the context of obesity. Her master's dissertation focused on the impact of obesogenic environments on offspring energy balance mechanisms. In this context, she has published an original article in Nutrients (10.3390/nu15051281), and a review paper in elucidating the relationship between neuropeptide Y and mitochondria in Biomedicine (10.3390/biomedicines11020446). Diana is also a coauthor of two original articles revealing the neurometabolic alterations in metabolic programming context (10.1016/j.lfs.2023.121597 and 10.3390/nu15163581). She as participated in international meetings, namely the European Congress of Clinical Investigation (ESCI) in 2022 and 2023 as an author and co-author of oral communications and posters, and in the European Association for the Study of Diabetes meeting in 2022 and 2023 (short oral communication). Regarding national congresses, Diana also presented oral communications at the Portuguese Congress of Diabetes in 2022 and 2023 and at the Portuguese Congress of Pharmacology in 2023.
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Identification

Personal identification

Full name
Diana Sousa

Citation names

  • Sousa, Diana

Author identifiers

Ciência ID
7013-2EFB-4953

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Physiology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2023/10/02 - 2027/09
Ongoing
 PhD Programme in Experimental Biology and Biomedicine (PDBEB) (Doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/09 - 2022/09
Concluded
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Offspring Programming of central and peripheral nutrient-sensing pathways by the exposition to perinatal obesogenic environments" (THESIS/DISSERTATION)
 19
2017/09 - 2020/07
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 15.1
Affiliation

Science

Category
Host institution 		Employer
2023/10/03 - Current Researcher (Research) Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
Horizon Europe, Belgium
2024/02/04 - 2024/03/05 Research Trainee (Research) Karolinska Institutet - Huddinge Campus, Sweden
2023/05 - 2023/09 Researcher (Research) Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
Fundação para a Ciência e a Tecnologia, Portugal
2021/10 - 2023/04 Research Trainee (Research) Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
2021/09 - 2021/09 Researcher (Research) Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
Fundação para a Ciência e a Tecnologia, Portugal
2021/02 - 2021/08 Research Trainee (Research) Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
2021/01 - 2021/01 Research Trainee (Research) CNC - Center for Neuroscience and Cell Biology, Portugal
2020/02/01 - 2020/06/30 Research Trainee (Research) Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
Projects

Grant

Designation Funders
2024/06 - Current New THerapeutIc strategies for obesity based oN peripheral dopamiNERgic signalling
2022.05822.PTDC
Member of the team
Fundação para a Ciência e a Tecnologia
Ongoing
2023/10/03 - Current Changeing the gut-adipose tissue axis: Mediterranean Diet on enteroendocrine and AT endothelial cells communication
101087071
PhD Student Fellow
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Horizon Europe
Ongoing
2023/03/03 - 2023/10/02 New THerapeutIc strategies for obesity based oN peripheral dopamiNERgic signalling
2022.05822.PTDC
Research Fellow
Fundação para a Ciência e a Tecnologia
Ongoing
2021/09 - 2021/09 (BII19): New Metabolic Therapies for Diabetes: CAPEOSBAC - Tailored microenCAPsulation technology for Extreme Oxygen-Sensitive BACteria with beneficial effects on gut microbiota
4539
Scientific Initiation Fellow
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference abstract
  1. Carina C. Magalhães; Amorim, Ricardo; Ana I. Duarte; Adriana Marques-Carvalho; Susana P. Pereira; Grilo, Luís F.; Mena, Débora; et al. "The mitochondriotropic antioxidant AntiOxBEN2 prevents hepatic steatosis in male and female mice fed with high-fat high-sugar (HFHS) diet". Paper presented in 58th Annual Meeting of the European Society for Clinical Investigation, Barcelona, 2024.
    Accepted
  2. Sousa, Diana; Amaro, Andreia; Rocha, Mariana; Ferreira Junior, Marcos Divino; Barra, Cátia; Mello-Gomes, Rodrigo; Matafome, Paulo. "Disruption of neuroendocrine mechanisms of energy balance in hypothalamus and brown adipose tissue in overfed rats exposed to maternal glycation". Paper presented in 58th Annual Scientific Meeting of the European Society of Clinical Investigation, Barcelona, 2024.
    Published
  3. Amaro, Andreia; Sousa, Diana; Rosendo-Silva, Daniela; Baptista, Filipa I.; Matafome, Paulo. "Postnatal overfeeding induces a sex-specific dysregulation of neuroendocrine mechanisms and an anxious-like behaviour in both Sexes". Paper presented in 58th Annual Meeting of the European Society for Clinical Investigation, Barcelona, 2024.
    Published
  4. Lopes, Eduardo; Rosendo-Silva, Daniela; Sousa, Diana; Ribeiro, Carina ; Conde, Sílvia; Matafome, Paulo. "Interação periférica entre o sistema dopaminérgico e melanocortinérgico como potencial alvo terapêutico para a desregulação metabólica associada à obesidade". Paper presented in 20th Portuguese Diabetes Congress Portuguese, Vilamoura, 2024.
    Published
  5. Amaro, Andreia; Sousa, Diana; Rosendo-Silva, Daniela; Baptista, Filipa I.; Matafome, Paulo. "O sistema npy/melanocortina é alterado pela sobrealimentação pós-natal em várias regiões do cérebro, estando associado a alterações comportamentais específicas de cada sexo". Paper presented in 20th Portuguese Diabetes Congress Portuguese, Vilamoura, 2024.
    Published
  6. Magalhães, Carina C.; Amorim, Ricardo; Duarte, Ana Isabel ; Carvalho, Adriana ; Pereira, Susana P.; Grilo, Luís; Mena, Débora; et al. "O impacto do antioxidante mitocondriotrópico antioxben2 na esteatose hepática de ratinhos no contexto de fígado gordo não-alcoólico". Paper presented in 20th Portuguese Diabetes Congress Portuguese, Vilamoura, 2024.
    Published
  7. Sousa, Diana; AMARO, ANDREIA; Mariana Rocha; Ferreira Junior, Marcos Divino; Barra, Cátia; Mello-Gomes, Rodrigo; Matafome, Paulo. "The dysregulation of energy balance crosstalk between the hypothalamus and the brown adipose tissue in overfed rats exposed to maternal glycation". Paper presented in 59 th EASD Annual Meeting of the European Association for the Study of Diabetes, Hamburg, 2023.
    Published
  8. AMARO, ANDREIA; Sousa, Diana; Mariana Rocha; Ferreira Junior, Marcos Divino; Saavedra, Lucas Paulo Jacinto; Barra, Cátia; Baptista, Filipa I.; Matafome, Paulo. "Postnatal overfeeding triggers sex-specific neurodevelopmental delay and induces anxious-like behaviour accompanied by brain-region-specific synaptic imbalance". Paper presented in 59 th EASD Annual Meeting of the European Association for the Study of Diabetes, Hamburg, 2023.
    Published
  9. Sousa, Diana; Amaro, A; Ferreira Junior, Marcos Divino; Pereira, Susana P.; Mariana Rocha; Barra, Cátia; Mello-Gomes, Rodrigo; J Paulo Oliveira; Matafome, Paulo. "Sexual dimorphism in the modulation of energy balance in adipose tissue induced by exposure to obesogenic environments". Paper presented in 57th Annual Scientific Meeting of the European Society for Clinical Investigation, Prague, 2023.
    Published
  10. Amaro, A; Mariana Rocha; Sousa, Diana; Ferreira Junior, Marcos Divino; Saavedra, Lucas Paulo Jacinto; Mello-Gomes, Rodrigo; Baptista, Filipa I.; Matafome, Paulo. "Postnatal overweight- induced offspring neurodevelopment and behaviour alterations associated with synaptic imbalance, according to sex-specific vulnerabilities". Paper presented in 57th Annual Scientific Meeting of the European Society for Clinical Investigation, Prague, 2023.
    Published
  11. Sousa, Diana; Rocha, Mariana; Amaro, Andreia; Ferreira Junior, Marcos Divino; Barra, Cátia; Mello-Gomes, Rodrigo; Matafome, Paulo. "Mecanismos compensatórios de balanço energético induzidos por sobrepeso pós-natal são prejudicados em condições maternas não saudáveis". Paper presented in 19th Portuguese Diabetes Congress, Vilamoura, 2023.
    Published
  12. Amaro, Andreia; Sousa, Diana; Rocha, Mariana; Barra, Cátia; Monteiro, Tamaeh; Ferreira Junior, Marcos Divino; Baptista, Filipa I.; Matafome, Paulo. "A exposição à glicação materna induz vulnerabilidades específicas do sexo no neurometabolismo e comportamento da descendência associadas a alterações sinápticas". Paper presented in 19th Portuguese Diabetes Congress, Vilamoura, 2023.
    Published
  13. Sousa, Diana; Amaro, A; Ferreira Junior, Marcos Divino; Susana P. Pereira; Rocha, Mariana; Barra, Cátia; Mello-Gomes, Rodrigo; Oliveira, Paulo; Matafome, Paulo. "Exposure to obesogenic environments during perinatal development modulates offspring nutrient sensing pathways in adipose tissue". Paper presented in 58th European Association for the Study of Diabetes Annual Meeting, Stockholm, 2022.
    Published
  14. Amaro, A; Rocha, Mariana; Sousa, Diana; Ferreira Junior, Marcos Divino; Barra, Cátia; Monteiro-Alfredo, Tamaeh; Mello-Gomes, Rodrigo; Baptista, Filipa I.; Matafome, Paulo. "Neurometabolic and behavioural alterations in the adolescent offspring upon maternal glycation". Paper presented in 58th European Association for the Study of Diabetes Annual Meeting, Stockholm, 2022.
    Published
  15. Sousa, Diana; Amaro, A; Ferreira Junior, Marcos Divino; Susana P. Pereira; Rocha, Mariana; Barra, Cátia; Mello-Gomes, Rodrigo; Oliveira, Paulo; Matafome, Paulo. "Exposure to obesogenic environments during perinatal development modulates offspring nutrient sensing pathways in adipose tissue.". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022.
    Published
  16. Amaro, A; Rocha, Mariana; Sousa, Diana; Ferreira Junior, Marcos Divino; Barra, Cátia; Monteiro-Alfredo, Tamaeh; Mello-Gomes, Rodrigo; Baptista, Filipa I.; Matafome, Paulo. "Neurometabolic and behavioural alterations in the adolescent offspring upon maternal glycation.". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022.
    Published
  17. Rocha, Mariana; Amaro, Andreia; Ferreira Junior, Marcos Divino; Pereira, Susana P.; Sousa, Diana; Barra, Cátia; Mello-Gomes, Rodrigo; Oliveira, Paulo J.; Matafome, Paulo. "Dieta materna hipercalórica durante a gestação e lactação e desenvolvimento da resistência à insulina: papel das glicotoxinas da dieta". Paper presented in 18th Portuguese Diabetes Congress, Vilamoura, 2022.
    Published
  18. Amaro, Andreia; Rocha, Mariana; Sousa, Diana; Ferreira Junior, Marcos Divino; Barra, Cátia; Monteiro, Tamaeh; Baptista, Filipa I.; Matafome, Paulo. "A glicação materna acelera o neurodesenvolvimento dos descendentes, induzindo alterações metabólicas e um comportamento menos ansioso na adolescência". Paper presented in 18th Portuguese Diabetes Congress, Vilamoura, 2022.
    Published
  19. Sousa, Diana; Amaro, Andreia; Ferreira Junior, Marcos Divino; Pereira, Susana P.; Rocha, Mariana; Barra, Cátia; Mello-Gomes, Rodrigo; Oliveira, Paulo J.; Matafome, Paulo. "O desenvolvimento perinatal em ambientes obesogénicos provoca alterações nas vias de sensibilidade aos nutrientes". Paper presented in 18th Portuguese Diabetes Congress, Vilamoura, 2022.
    Published
Journal article
  1. Sousa, Diana; Magalhães, Carina C.; Matafome, Paulo; Pereira, Susana P.. "Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity". Bioscience Reports 44 8 (2024): http://dx.doi.org/10.1042/bsr20231679.
    Published • 10.1042/bsr20231679
  2. Amaro, Andreia; Sousa, Diana; Sá-Rocha, Mariana; Ferreira-Junior, Marcos Divino; Rosendo-Silva, Daniela; Saavedra, Lucas Paulo Jacinto; Barra, Cátia; et al. "Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-like Behaviour Accompanied by Sex- and Brain-Region-Specific Synaptic and Metabolic Changes". Nutrients 15 16 (2023): 3581. http://dx.doi.org/10.3390/nu15163581.
    10.3390/nu15163581
  3. Sousa, Diana; Rocha, Mariana; Amaro, Andreia; Ferreira-Junior, Marcos Divino; Cavalcante, Keilah Valéria Naves; Monteiro-Alfredo, Tamaeh; Barra, Cátia; et al. "Exposure to Obesogenic Environments during Perinatal Development Modulates Offspring Energy Balance Pathways in Adipose Tissue and Liver of Rodent Models". Nutrients 15 5 (2023): 1281. http://dx.doi.org/10.3390/nu15051281.
    Published • 10.3390/nu15051281
  4. Amaro, Andreia; Sousa, Diana; Sá-Rocha, Mariana; Ferreira-Júnior, Marcos D.; Barra, Cátia; Monteiro, Tamaeh; Mathias, Paulo; et al. "Sex-specificities in offspring neurodevelopment and behaviour upon maternal glycation: Putative underlying neurometabolic and synaptic changes". Life Sciences (2023): 121597. http://dx.doi.org/10.1016/j.lfs.2023.121597.
    10.1016/j.lfs.2023.121597
  5. Sousa, Diana; Lopes, Eduardo; Rosendo-Silva, Daniela; Matafome, Paulo. "The Bidirectional Relationship of NPY and Mitochondria in Energy Balance Regulation". Biomedicines 11 2 (2023): 446. http://dx.doi.org/10.3390/biomedicines11020446.
    Published • 10.3390/biomedicines11020446
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/06/06 Disruption of neuroendocrine mechanisms of energy balance in hypothalamus and brown adipose tissue in overfed rats exposed to maternal glycation 58th Annual Scientific Meeting of the European Society of Clinical Investigation
European Society of Clinical Investigation (Barcelona, Spain)
2023/10/05 The dysregulation of energy balance crosstalk between the hypothalamus and the brown adipose tissue in overfed rats exposed to maternal glycation 59 th EASD Annual Meeting of the European Association for the Study of Diabetes
European Association for the Study of Diabetes (Hamburg, Germany)
2023/06/07 Sexual dimorphism in the modulation of energy balance in adipose tissue induced by exposure to obesogenic environments 57th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Prague, Czech Republic)
2023/03/17 Mecanismos compensatórios de balanço energético induzidos por sobrepeso pós-natal são prejudicados em condições maternas não saudáveis 19th Portuguese Diabetes Congress
Portuguese Society of Diabetes (Vilamoura, Portugal)
2023/02 Obesogenic environments exposure during perinatal development modulates energy balance in the adipose tissue of newborns 53rd Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2022/09 Exposure to obesogenic environments during perinatal development modulates offspring nutrient-sensing pathways in adipose tissue 58th European Association for the Study of Diabetes Annual Meeting
European Association for the Study of Diabetes (Stockholm, Sweden)
2022/06 Exposure to obesogenic environments during perinatal development modulates offspring nutrient-sensing pathways in adipose tissue. 56th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Bari, Italy)
2022/03 O desenvolvimento perinatal em ambientes obesogénicos provoca alterações nas vias de sensibilidade aos nutrientes 18th Portuguese Diabetes Congress
Portuguese Society of Diabetes (Vilamoura, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/09 - 2024/09 European Researchers' Night
Other
2023/09 - 2023/09 European Researchers' Night
Other
2023/01/12 - 2023/01/13 Attendance at lectures and volunteer to assist the organization committee
Meeting
 III Meeting of Metabolism, Aging and Disease (MAD) of CIBB
Centre for Innovative Biomedicine and Biotechnology (CIBB), Portugal
2021/11/17 - 2021/11/18 Attendance at lectures II Meeting of Metabolism, Aging and Disease (MAD) of CIBB
Center for Innovative Biomedicine and Biotechnology (CIBB), Portugal
2020/05 - 2020/05 Attendance at lectures
Seminar
 Bioeconomy for a Sustainable Future
Universidade de Coimbra, Portugal
2020/02/14 - 2020/02/16 Participation at the I University Biochemistry Olympics, obtaining the 10th place at national level Participation in workshops and lectures
Seminar
 I University Biochemistry Olympics
Universidade de Coimbra, Portugal
2018/02/15 - 2018/02/15 Attendance at lectures Session 2 of “Conversations with Ethics” – “CRISPR – copy --- paste de ADN. The new technologies of Genetic Engineering”
Universidade de Coimbra Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2022 - Current Portuguese Society of Diabetology
2022 - Current European Society for Clinical Investigation
2022 - Current European Association for the Study of Diabetes

Scientific expedition

Activity description Institution / Organization
2022/02/08 - 2022/02/08 Escola Ciência Viva - "What we eat" for children aged 3 to 6 Center for Innovative Biomedicine and Biotechnology (CIBB), Portugal