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Feng Mei. Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Neurosciences.
Identification

Personal identification

Full name
Feng Mei

Citation names

  • Mei, Feng

Author identifiers

Ciência ID
701A-5CB3-A1CF
ORCID iD
0000-0003-4125-1570

Email addresses

  • meifeng.mail@163.com (Professional)
  • meif@tmmu.edu.cn (Professional)

Telephones

Mobile phone
  • (+86) 3594000923 (Personal)
Telephone
  • (+86) 2368771317 (Professional)

Addresses

  • 30 Gaotanyan Street, , 400038, Shapingba , Chongqing, China (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Chinese (Mother tongue)
Education
Degree Classification
2002/09/01 - 2008
Concluded
 Neurobiology (Doctor of Philosophy)
Major in Neurobiology
Third Military Medical University, China
1997 - 2002
Concluded
 Clinical Medicine (Bachelor)
Major in Clinic medicine
Third Military Medical University, China
Affiliation

Science

Category
Host institution 		Employer
2012/09/01 - 2015/07/01 Postdoc (Research) University of California San Francisco, United States

Teaching in Higher Education

Category
Host institution 		Employer
2016/09/01 - Current Full Professor (University Teacher) Third Military Medical University-Basic Medical College, China
2010/09/01 - 2016/08/31 Associate Professor (University Teacher) Third Military Medical University-Basic Medical College, China
2008 - 2010 Lecturer (University Teacher) Third Military Medical University-Basic Medical College, China
Third Military Medical University-Basic Medical College, China
Projects

Grant

Designation Funders
2020/01/01 - 2023/12/31 Muscarinic receptor signaling in regulating oligodendrocyte-axon recognition
31970916
Principal investigator
Army Medical University, China
 National Science Funding of China
Ongoing
2019/05/01 - 2022/04/30 Myelination as a means of neural plasticity
cstc2019jcyjjqx0001
Principal investigator
Army Medical University, China
Ongoing
2018/01/01 - 2021/12/31 Kappa opioid receptor in regulating oligodendroglial differentiation and myelination
31771120
Principal investigator
Army Medical University, China

Third Military Medical University, China
National Science Funding of China
Ongoing
Outputs

Publications

Book chapter
  1. Wang, Fei; Mei, Feng. "Kappa opioid receptor and oligodendrocyte remyelination". In Vitamins and Hormones, 281-297. Elsevier, 2019.
    10.1016/bs.vh.2019.05.004
  2. Huang, Nan-Xing; Shen, Yun-An A.; Mei, Feng. "Modeling CNS Myelination Using Micropillar Arrays". In Methods in Molecular Biology, 169-177. Springer New York, 2018.
    Published • 10.1007/978-1-4939-7862-5_13 • Editor
Journal article
  1. Wang, Fei; Ren, Shu-Yu; Chen, Jing-Fei; Liu, Kun; Li, Rui-Xue; Li, Zhi-Fang; Hu, Bo; et al. "Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory". Nature Neuroscience 23 4 (2020): 481-486. http://dx.doi.org/10.1038/s41593-020-0588-8.
    10.1038/s41593-020-0588-8
  2. Wang, Fei; Yang, Yu-Jian; Yang, Nian; Chen, Xian-Jun; Huang, Nan-Xin; Zhang, Jun; Wu, Yi; et al. "Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia". Neuron 99 4 (2018): 689-701.e5. http://dx.doi.org/10.1016/j.neuron.2018.07.017.
    Published • 10.1016/j.neuron.2018.07.017
  3. Li, Tao; Wang, Jingjing; Wang, Hongkai; Yang, Yujian; Wang, Shouyu; Huang, Nanxin; Wang, Fei; et al. "The deletion of dicer in mature myelinating glial cells causes progressive axonal degeneration but not overt demyelination in adult mice". Glia 66 9 (2018): 1960-1971. http://dx.doi.org/10.1002/glia.23450.
    Published • 10.1002/glia.23450
  4. Cree, Bruce A C; Niu, Jianqin; Hoi, Kimberly K; Zhao, Chao; Caganap, Scott D; Henry, Roland G; Dao, Dang Q; et al. "Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury". Brain 141 1 (2017): 85-98. http://dx.doi.org/10.1093/brain/awx312.
    Published • 10.1093/brain/awx312
  5. Green, Ari J; Gelfand, Jeffrey M; Cree, Bruce A; Bevan, Carolyn; Boscardin, W John; Mei, Feng; Inman, Justin; et al. "Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial". The Lancet 390 10111 (2017): 2481-2489. http://dx.doi.org/10.1016/s0140-6736(17)32346-2.
    Published • 10.1016/s0140-6736(17)32346-2
  6. Mei, Feng; Lehmann-Horn, Klaus; Shen, Yun-An A; Rankin, Kelsey A; Stebbins, Karin J; Lorrain, Daniel S; Pekarek, Kara; et al. "Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery". eLife 5 (2016): http://dx.doi.org/10.7554/elife.18246.
    10.7554/elife.18246
  7. Redmond, Stephanie A.; Mei, Feng; Eshed-Eisenbach, Yael; Osso, Lindsay A.; Leshkowitz, Dena; Shen, Yun-An A.; Kay, Jeremy N.; et al. "Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination". Neuron 91 4 (2016): 824-836. http://dx.doi.org/10.1016/j.neuron.2016.07.021.
    Published • 10.1016/j.neuron.2016.07.021
  8. Mei, Feng; Mayoral, Sonia R.; Nobuta, Hiroko; Wang, Fei; Desponts, Caroline; Lorrain, Daniel S.; Xiao, Lan; et al. "Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination". The Journal of Neuroscience 36 30 (2016): 7925-7935. http://dx.doi.org/10.1523/jneurosci.1493-16.2016.
    Published • 10.1523/jneurosci.1493-16.2016
  9. Etxeberria, A.; Hokanson, K. C.; Dao, D. Q.; Mayoral, S. R.; Mei, F.; Redmond, S. A.; Ullian, E. M.; Chan, J. R.. "Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity". Journal of Neuroscience 36 26 (2016): 6937-6948. http://dx.doi.org/10.1523/jneurosci.0908-16.2016.
    Published • 10.1523/jneurosci.0908-16.2016
  10. von Büdingen, H.-Christian; Mei, Feng; Greenfield, Ariele; Jahn, Sarah; Shen, Yun-An A.; Reid, Hugh H.; McKemy, David D.; Chan, Jonah R.. "The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry". Journal of Cell Biology 210 6 (2015): 891-898. http://dx.doi.org/10.1083/jcb.201504106.
    10.1083/jcb.201504106
  11. Wang, Hongkai; Shen, Weiwei; Hu, Xu; Zhang, Ying; Zhuo, Yunyun; Li, Tao; Mei, Feng; et al. "Quetiapine inhibits osteoclastogenesis and prevents human breast cancer-induced bone loss through suppression of the RANKL-mediated MAPK and NF-¿B signaling pathways". Breast Cancer Research and Treatment 149 3 (2015): 705-714. http://dx.doi.org/10.1007/s10549-015-3290-x.
    Published • 10.1007/s10549-015-3290-x
  12. Mei, F.; Wang, H.; Liu, S.; Niu, J.; Wang, L.; He, Y.; Etxeberria, A.; Chan, J. R.; Xiao, L.. "Stage-Specific Deletion of Olig2 Conveys Opposing Functions on Differentiation and Maturation of Oligodendrocytes". Journal of Neuroscience 33 19 (2013): 8454-8462. http://dx.doi.org/10.1523/jneurosci.2453-12.2013.
    Published • 10.1523/jneurosci.2453-12.2013
  13. Mei, Feng; Christin Chong, S. Y.; Chan, Jonah R.. "Myelin-based inhibitors of oligodendrocyte myelination: clues from axonal growth and regeneration". Neuroscience Bulletin 29 2 (2013): 177-188. http://dx.doi.org/10.1007/s12264-013-1319-x.
    Published • 10.1007/s12264-013-1319-x
  14. Mei, Feng; Guo, Sheng; He, Yangtao; Wang, Linyun; Wang, Hongkai; Niu, Jianqin; Kong, Jiming; et al. "Quetiapine, an Atypical Antipsychotic, Is Protective against Autoimmune-Mediated Demyelination by Inhibiting Effector T Cell Proliferation". PLoS ONE 7 8 (2012): e42746. http://dx.doi.org/10.1371/journal.pone.0042746.
    10.1371/journal.pone.0042746
  15. Niu, Jianqin; Mei, Feng; Wang, Lingyun; Liu, Shubao; Tian, Yanping; Mo, Wei; Li, Hongli; Lu, Q. Richard; Xiao, Lan. "Phosphorylated olig1 localizes to the cytosol of oligodendrocytes and promotes membrane expansion and maturation". Glia 60 9 (2012): 1427-1436. http://dx.doi.org/10.1002/glia.22364.
    Published • 10.1002/glia.22364
  16. He, Xiao; Yang, Wen-cui; Wen, Xiang-yin; Tang, Di; Xiao, Lan; Han, Juan; Yu, Bin; Zhang, Wei; Mei, Feng. "Late Embryonic and Postnatal Development of Interstitial Cells of Cajal in Mouse Esophagus: Distribution, Proliferation and Kit Dependence". Cells Tissues Organs 196 2 (2012): 175-188. http://dx.doi.org/10.1159/000332381.
    10.1159/000332381
  17. Zhou, Yin-Pin; He, Yang-Tao; Chen, Cheng-Li; Ji, Jun; Niu, Jian-Qin; Wang, Han-Zhi; Li, Shi-Feng; Huang, Lan; Mei, Feng. "Time-specific blockade of PDGFR with Imatinib (Glivec®) causes cataract and disruption of lens fiber cells in neonatal mice". Virchows Archiv 458 3 (2010): 349-356. http://dx.doi.org/10.1007/s00428-010-1024-3.
    Published • 10.1007/s00428-010-1024-3
  18. Niu, Jianqin; Mei, Feng; Li, Nan; Wang, Hanzhi; Li, Xinmin; Kong, Jiming; Xiao, Lan. "Haloperidol promotes proliferation but inhibits differentiation in rat oligodendrocyte progenitor cell culturesThis paper is one of a selection of papers published in this special issue entitled “Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine” and has undergone the Journal's usual peer review process.". Biochemistry and Cell Biology 88 4 (2010): 611-620. http://dx.doi.org/10.1139/o09-178.
    10.1139/o09-178
  19. Guo, Sheng; Yang, Chengying; Mei, Feng; Wu, Shengxi; Luo, Na; Fei, Lei; Chen, Yongwen; Wu, Yuzhang. "Down-regulation of Z39Ig on macrophages by IFN-¿ in patients with chronic HBV infection". Clinical Immunology 136 2 (2010): 282-291. http://dx.doi.org/10.1016/j.clim.2010.03.007.
    Published • 10.1016/j.clim.2010.03.007
  20. Wang, Hanzhi; Xu, Haiyun; Niu, Jianqin; Mei, Feng; Li, Xinmin; Kong, Jiming; Cai, Wenqin; Xiao, Lan. "Haloperidol activates quiescent oligodendroglia precursor cells in the adult mouse brain". Schizophrenia Research 119 1-3 (2010): 164-174. http://dx.doi.org/10.1016/j.schres.2010.02.1068.
    10.1016/j.schres.2010.02.1068
  21. Han, Juan; Zhou, Yin-Pin; Jiang, You-Zhao; He, Yang-Tao; Mei, Feng. "Postnatal development of interstitial cells of Cajal in mouse colon in response to Kit signal blockade with Imatinib (Glivec®)". Acta Histochemica 112 3 (2010): 215-221. http://dx.doi.org/10.1016/j.acthis.2010.02.003.
    Published • 10.1016/j.acthis.2010.02.003
  22. Han, Juan; Shen, Wen-Hao; Jiang, You-Zhao; Yu, Bin; He, Yang-Tao; Li, Nan; Mei, Feng. "Distribution, development and proliferation of interstitial cells of Cajal in murine colon: an immunohistochemical study from neonatal to adult life". Histochemistry and Cell Biology 133 2 (2009): 163-175. http://dx.doi.org/10.1007/s00418-009-0655-4.
    Published • 10.1007/s00418-009-0655-4
  23. Mei, Feng; Han, Juan; Huang, Yue; Jiang, Zhong-Yong; Xiong, Cheng-Jie; Zhou, De-Shan. "Plasticity of Interstitial Cells of Cajal: A Study in the Small Intestine of Adult Guinea Pigs". The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 292 7 (2009): 985-993. http://dx.doi.org/10.1002/ar.20928.
    Published • 10.1002/ar.20928
  24. Yu, Bin; Han, Juan; He, Yang-tao; Guo, Sheng; Li, Shi-feng; Mei, Feng. "Immunohistochemical study of CD44 immunopositive cells in the muscular layers of the gastrointestinal tract in adult guinea pigs and mice". Acta Histochemica 111 4 (2009): 383-391. http://dx.doi.org/10.1016/j.acthis.2008.12.003.
    Published • 10.1016/j.acthis.2008.12.003
  25. Huang, Yue; Mei, Feng; Yu, Bin; Zhang, Hong-jun; Han, Juan; Jiang, Zhong-yong; Zhou, De-shan. "Distribution of the interstitial Cajal-like cells in the gallbladder and extrahepatic biliary duct of the guinea-pig". Acta Histochemica 111 2 (2009): 157-165. http://dx.doi.org/10.1016/j.acthis.2008.05.005.
    Published • 10.1016/j.acthis.2008.05.005
  26. Mei, Feng; Guo, Sheng; He, Yang-tao; Zhu, Jiang; Zhou, De-shan; Niu, Jian-qin; Wang, Han-zhi; Tian, Yan-ping. "Apoptosis of interstitial cells of Cajal, smooth muscle cells, and enteric neurons induced by intestinal ischemia and reperfusion injury in adult guinea pigs". Virchows Archiv 454 4 (2009): 401-409. http://dx.doi.org/10.1007/s00428-009-0739-5.
    Published • 10.1007/s00428-009-0739-5
  27. Mei, Feng; Zhu, Jiang; Guo, Sheng; Zhou, De-shan; Han, Juan; Yu, Bin; Li, Shi-feng; Jiang, Zhong-yong; Xiong, Cheng-jie. "An age-dependent proliferation is involved in the postnatal development of interstitial cells of Cajal in the small intestine of mice". Histochemistry and Cell Biology 131 1 (2008): 43-53. http://dx.doi.org/10.1007/s00418-008-0515-7.
    Published • 10.1007/s00418-008-0515-7
  28. Mei, Feng; Yu, Bin; Ma, Hua; Zhang, Hong-jun; Zhou, De-shan. "Interstitial cells of Cajal could regenerate and restore their normal distribution after disrupted by intestinal transection and anastomosis in the adult guinea pigs". Virchows Archiv 449 3 (2006): 348-357. http://dx.doi.org/10.1007/s00428-006-0258-6.
    Published • 10.1007/s00428-006-0258-6
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/08/06 Enhancing myelination promotes synaptogenesis and functional recovery after hypoxic insults. Annual meeting of Chinese Anatomy Society
Chinese Anatomy Society (China)
2017/10/15 Can enhancing myelination preserve neurofunction in hypoxic mice? Annual meeting of Chinese Neuroscience Society
Chinese Neuroscience Society (China)
2016/10/13 Remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery. Collaborative strategies to study myelin and fight against multiple sclerosis and other white matter disorders
University College London (London, United Kingdom)
2015/01/30 Do remyelination therapies offer a promising approach for protecting axons against degeneration in Multiple Sclerosis?
UCSF, Multiple Sclerosis research group (United States)
2014/03/01 Fabricated micropillar arrays as a novel high-throughput screening platform for potential therapeutics in Multiple Sclerosis Gordon Research Seminars-Myelin
Gordon Research
Distinctions

Award

2019 Outstanding Young Investigator of Chongqing
Chongqing Municipal People's Government, China
2019 Changjiang Scholar Young Investigator
Ministry of Education of the People's Republic of China, China
2010 Distinguished Paper Selected by The Chinese Society for Anatomical Sciences
2010 Oversea Scholars Exchange Program
2009 Outstanding Doctoral Dissertation of Third Military Medical University
Army Medical University, China
2009 Outstanding Doctoral Dissertation of Chongqing
2008 Outstanding Graduate Student of Third Military Medical University
Army Medical University, China
2002 Outstanding Medical Student of Third Military Medical University
Army Medical University, China