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Juliana Calheiros graduated in Biochemistry at the University of Aveiro (2014) and she obtained her Master degree in Biochemistry, specialization in Clinical Biochemistry (2016), at the University of Aveiro. During 2017 to 2019, she was a research fellow at IPATIMUP/i3S, working on glycobiomarkers as tools of cancer prognosis. During 2019 to 2020, she was a research fellow at LAQV/REQUIMTE, working on targeted-anticancer therapies. Currently, she is a PhD student at DRUG DISCOVERY & DEVELOPMENT RESEARCH UNIT/LAQV/REQUIMTE/FFUP, aiming to identify and validate new pharmacological DNA repair inhibitors as targeted anticancer agents. Published 9 articles in international peer-reviewed journals and 3 international proceedings. Has 11 oral communications, 5 posters, 1 patent application and received 2 awards. Co-supervised 3 BSc students. Participated in several scientific events/courses/workshops. She works in Medical and Health Sciences field, with emphasis on Cancer Pharmacology and Oncobiology.
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Identification

Personal identification

Full name
Juliana Meixedo Calheiros

Citation names

  • Calheiros, Juliana

Author identifiers

Ciência ID
701D-B736-5256
ORCID iD
0000-0001-5895-6951
AuthenticusID
R-00J-DC1
Google Scholar ID
PHRKDY4AAAAJ
Researcher Id
AAG-9714-2019
Scopus Author Id
57214054063

Email addresses

  • julianameixedo@ua.pt (Professional)
  • up202010038@edu.ff.up.pt (Professional)

Addresses

  • Rua Jorge Viterbo Ferreira, nº228, 4050-313, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2020 - 2024
Ongoing
 Programa Doutoral em Ciências Farmacêuticas (Doutoramento)
Major in Farmacologia e Farmacoterapia
Universidade do Porto Faculdade de Farmácia, Portugal
"TARGETING BRCA1/2-MEDIATED DNA REPAIR FOR PERSONALIZED CANCER PREVENTION AND THERAPY" (THESIS/DISSERTATION)
2021/09/06 - 2021/09/17
Concluded
 FELASA Accredited Advanced Course in Laboratory Animal Science (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Approved
2014/08/27 - 2016/07/25
Concluded
 Bioquímica (Mestrado)
Major in Bioquímica Clínica
Universidade de Aveiro, Portugal

Universidade de Aveiro Departamento de Química, Portugal
"Purificação de IgY e avaliação da sua atividade/estabilidade em soluções aquosas de polímeros, sais e líquidos iónicos" (THESIS/DISSERTATION)
 17
2011/09/21 - 2014/06/26
Concluded
 Bioquímica (Licenciatura)
Universidade de Aveiro, Portugal

Universidade de Aveiro Departamento de Química, Portugal
"Estratégias bioinformáticas aplicadas ao estudo de doenças neurodegenerativas" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2020/10/01 - 2024/09/30 Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
(...)
2019/09/01 - 2020/10/01 Researcher (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2017/05/01 - 2019/04/30 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Others

Category
Host institution 		Employer
2015 - 2016 Master thesis student Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
Universidade de Aveiro, Portugal
Projects

Grant

Designation Funders
2019/09/01 - 2020/10/01 Identification of compounds with potential antitumor activity dependent on the activation of p53 family proteins
UID/QUI/50006/2019
Research Fellow
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

REQUIMTE LAQV Porto, Portugal
FCT/MCTES
Ongoing
2017/05/01 - 2019/04/30 "Advancing cancer research from basic knowledgement to application" - "Glycosylation of tyrosine kinase receptors as novel biomarkers for targeted therapy"
NORTE-01-0154-FEDER-000029
Research Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
NORTE2020
Concluded
Outputs

Publications

Conference paper
  1. Calheiros, Juliana; Ramos, Helena; Carvalho, Carla; Barcherini, Valentina; M. M. Santos, Maria; Saraiva, Lucília. "SLMP53-1 inhibits tumor cell growth through regulation of glucose metabolism and angiogenesis in a P53-dependent manner". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020.
    Published • 10.3390/ecmc2020-07400
  2. Raimundo, Liliana; Gomes, Sara; Soares, Joana; Loureiro, Joana; Leão, Mariana; Ramos, Helena; Monteiro, Madalena; et al. "Targeting neuroblastoma with a new inhibitor of the TAp73 interaction with MDM2 and mutant p53". Paper presented in 5th International Electronic Conference on Medicinal Chemistry, 2019.
    Published • 10.3390/ecmc2019-06305
  3. Raimundo, Liliana; Espadinha, Margarida; Soares, Joana; Loureiro, Joana; Calheiros, Juliana; Nazareth, Nair; Almeida, Joana; et al. "Improving colon cancer therapy with a new promising small-molecule activator of the p53-pathway through disruption of p53-MDM2/MDMX interactions". Paper presented in 5th International Electronic Conference on Medicinal Chemistry, 2019.
    Published • 10.3390/ecmc2019-06306
Journal article
  1. Calheiros, Juliana; Raimundo, Liliana; Morais, João; Matos, Ana Catarina; Minuzzo, Sonia Anna; Indraccolo, Stefano; Sousa, Emília; Silva, Marta Correia da; Saraiva, Lucília. "Antitumor Activity of the Xanthonoside XGAc in Triple-Negative Breast, Ovarian and Pancreatic Cancer by Inhibiting DNA Repair". Cancers 15 24 (2023): 5718. http://dx.doi.org/10.3390/cancers15245718.
    Published • 10.3390/cancers15245718
  2. Calheiros, Juliana; Corbo, Vincenzo; Saraiva, Lucília. "Overcoming therapeutic resistance in pancreatic cancer: Emerging opportunities by targeting BRCAs and p53". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878 4 (2023): 188914. http://dx.doi.org/10.1016/j.bbcan.2023.188914.
    10.1016/j.bbcan.2023.188914
  3. Raimundo, Liliana; Calheiros, Juliana; Saraiva, Lucília. "Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target". Cancers 13 14 (2021): 3438. http://dx.doi.org/10.3390/cancers13143438.
    Published • 10.3390/cancers13143438
  4. Raimundo, Liliana; Paterna, Ângela; Calheiros, Juliana; Ribeiro, Joana; Cardoso, David; Piga, Ilaria; Neto, Susana Junqueira; et al. "BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer". British Journal of Pharmacology (2021): http://dx.doi.org/10.1111/bph.15506.
    Published • 10.1111/bph.15506
  5. Loureiro, Joana B.; Raimundo, Liliana; Calheiros, Juliana; Carvalho, Carla; Barcherini, Valentina; Lima, Nuno R.; Gomes, Célia; et al. "Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance". Cancers 13 7 (2021): 1648. http://dx.doi.org/10.3390/cancers13071648.
    Published • 10.3390/cancers13071648
  6. Ramos, Helena; Soares, Maria I.L.; Silva, Joana; Raimundo, Liliana; Calheiros, Juliana; Gomes, Célia; Reis, Flávio; et al. "A selective p53 activator and anticancer agent to improve colorectal cancer therapy". Cell Reports 35 2 (2021): 108982. http://dx.doi.org/10.1016/j.celrep.2021.108982.
    Published • 10.1016/j.celrep.2021.108982
  7. Ramos, Helena; Calheiros, Juliana; Almeida, Joana; Barcherini, Valentina; Santos, Sónia; Carvalho, Alexandra T. P.; Santos, Maria M.M.; Saraiva, Lucília. "SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner". International Journal of Molecular Sciences 21 2 (2020): 596. http://dx.doi.org/10.3390/ijms21020596.
    Published • 10.3390/ijms21020596
  8. Raimundo, Liliana; Ramos, Helena; Loureiro, Joana B.; Calheiros, Juliana; Saraiva, Lucília. "BRCA1/P53: Two strengths in cancer chemoprevention". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1873 1 (2020): 188339. http://dx.doi.org/10.1016/j.bbcan.2020.188339.
    Published • 10.1016/j.bbcan.2020.188339
  9. Gomes, Catarina; Almeida, Andreia; Barreira, Ana; Calheiros, Juliana; Pinto, Filipe; Abrantes, Rafaela; Costa, Ana; et al. "Carcinoembryonic antigen carrying SLeX as a new biomarker of more aggressive gastric carcinomas". Theranostics 9 24 (2019): 7431-7446. http://dx.doi.org/10.7150/thno.33858.
    Published • 10.7150/thno.33858
Thesis / Dissertation
  1. Calheiros, Juliana. "Purificação de IgY e avaliação da sua atividade/estabilidade em soluções aquosas de polímeros, sais e líquidos iónicos". Master, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/21213.

Intellectual property

Patent
  1. Lucília Saraiva; Maria José Umbelino Ferreira; Silva Mulhovo; José Luis Costa; Liliana Gomes Raimundo; Angela Paterna; Calheiros, Juliana. 2020. "BBIT20: a new inhibitor of BRCA1 mediated homologous recombination DNA repair".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/05/10 Targeting BRCA1-mediated DNA repair in pancreatic ductal adenocarcinoma therapy IJUP 2023
Universidade do Porto (Porto, Portugal)
2023/02/03 Targeting pancreatic cancer with a BRCAness inducer agent 53ª Reunião da Sociedade Portuguesa de Farmacologia, 41ª Reunião de Farmacologia Clínica e 22ª Reunião de Toxicologia
Universidade de Coimbra Faculdade de Medicina (Coimbra, Portugal)
2023/02/01 Overcoming pancreatic cancer drug resistance with a new inhibitor of BRCA1-mediated homologous recombination 53ª Reunião da Sociedade Portuguesa de Farmacologia, 41ª Reunião de Farmacologia Clínica e 22ª Reunião de Toxicologia
Universidade de Coimbra Faculdade de Medicina (Coimbra, Portugal)
2022/05/05 Targeting homologous recombination DNA repair in pancreatic ductal adenocarcinoma therapy IJUP 2022
Universidade do Porto (Porto, Portugal)
2022/03 [E-POSTER] Targeting homologous recombination DNA repair in pancreatic ductal adenocarcinoma therapy Annual International (bio)Medical Students Meeting 2022
Faculdade de Medicina da Universidade de Lisboa (Lisboa, Portugal)
2021/05/05 [E-POSTER] A potential inhibitor of homologous recombination DNA repair in triple-negative breast cancer IJUP 2021
Universidade do Porto (Porto, Portugal)
2021/02/19 A xanthone with anticancer activity by potential inhibition of homologous recombination DNA repair in breast and ovarian cancer Sociedade Portuguesa de Farmacologia Meeting 2021
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2021/02/17 SLMP53-2: promising anti-tumor activity in melanoma by targeting p53 Sociedade Portuguesa de Farmacologia Meeting 2021
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2020/09/24 [POSTER] BBIT20: um novo inibidor da recombinação homóloga e potencial agente anticancerígeno no tratamento de cancros da mama triplo negativos e do ovário 2º Encontro Nacional de Jovens Investigadores em Oncologia
Liga Portuguesa Contra o Cancro – NRN (Porto, Portugal)
2020/02/07 Regulation of glucose metabolism, angiogenesis and migration of colon cancer by the p53 activator SLMP53-1 L Reunião da Sociedade Portuguesa de Farmacologia, XXXVIII Reunião de Farmacologia Clínica e XIX Reunião de Toxicologia
Faculdade de Farmácia da Universidade de Coimbra, SPF (Sociedade Portuguesa de Farmacologia) (Coimbra, Portugal)
2020/02/07 SLMP53-2: a mutant p53 reactivator with promising activity in skin cancer prevention L Reunião da Sociedade Portuguesa de Farmacologia, XXXVIII Reunião de Farmacologia Clínica e XIX Reunião de Toxicologia
Faculdade de Farmácia da Universidade de Coimbra, SPF (Sociedade Portuguesa de Farmacologia) (Coimbra, Portugal)
2020/02/07 New inhibitor of the BRCA1-BARD1 interaction with anticancer activity in BRCA1-deficient breast and ovarian cancer L Reunião da Sociedade Portuguesa de Farmacologia, XXXVIII Reunião de Farmacologia Clínica e XIX Reunião de Toxicologia
Faculdade de Farmácia da Universidade de Coimbra, SPF (Sociedade Portuguesa de Farmacologia) (Coimbra, Portugal)
2015/04/29 [POSTER] "Review: relação entre HDL-colesterol e triglicerídeos e o risco de desenvolvimento de cancros gastrointestinais" 7th Biochemistry Day, Biochemistry and Well-being
Universidade de Aveiro (Aveiro, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/02 - 2022/07 Targeting BRCA1-mediated DNA repair in pancreatic ductal adenocarcinoma therapy
Co-supervisor
 Licenciatura em Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2021/02 - 2021/07 Targeting BRCA1 and BRCA2 Tumour Suppressor Proteins in Breast and Ovarian Cancers
Co-supervisor
 Licenciatura em Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2020 - 2021/07 Targeting BRCA1 Tumour Suppressor Protein: Searching For New Effective Anticancer Therapeutic Options
Co-supervisor
 Licenciatura em Biologia (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/03/06 - 2023/03/06 MODEL ORGANISMS: POWERFUL TOOLS IN HEALTH RESEARCH (2023/03/06 - 2023/03/06)
Workshop (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/02/01 - 2023/02/03 53ª Reunião da Sociedade Portuguesa de Farmacologia, 41ª Reunião de Farmacologia Clínica e 22ª Reunião de Toxicologia
Meeting
 53ª Reunião da Sociedade Portuguesa de Farmacologia, 41ª Reunião de Farmacologia Clínica e 22ª Reunião de Toxicologia
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/02/09 - 2022/02/11 Sociedade Portuguesa de Farmacologia Meeting 2022
Congress
 LII Reunião da Sociedade Portuguesa de Farmacologia, XL Reunião de Farmacologia Clínica e XXI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/10/14 - 2021/10/15 II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer
Meeting
 II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer
ASPIC, Portugal
2021/03/17 - 2021/03/17 From in silico to animal models for the study of human diseases
Workshop
 From in silico to animal models for the study of human diseases
Universidade de Aveiro, Portugal

Universidade de Aveiro Instituto de Biomedicina, Portugal

Universidade de Aveiro Departamento de Química, Portugal
2021/02/17 - 2021/02/19 Sociedade Portuguesa de Farmacologia Meeting 2021
Congress
 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/02/05 - 2020/02/07 Sociedade Portuguesa de Farmacologia Meeting 2020
Congress
 L Reunião da Sociedade Portuguesa de Farmacologia, XXXVIII Reunião de Farmacologia Clínica e XIX Reunião de Toxicologia
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/11/15 - 2019/11/15 Day Of The Microbiology Laboratory | 2019: Microbiology, Immunology and Oncobiology: interdisciplinary approaches to control infectious diseases and cancer
Meeting
 Day Of The Microbiology Laboratory | 2019: Microbiology, Immunology and Oncobiology: interdisciplinary approaches to control infectious diseases and cancer
Universidade do Porto Faculdade de Farmácia, Portugal
2019/05/31 - 2019/06/01 Curso de Patologia Molecular "from bench to bedside" (9,5h duration)
Other
 Curso de Patologia Molecular "from bench to bedside"
Núcleo de Internos da Sociedade Portuguesa de Anatomia Patológica, Portugal
2018/10/26 - 2018/10/26 Conferência ASPIC "Cancro Colorretal em Portugal: da investigação à prevenção e ao tratamento"
Conference
 Conferência ASPIC "Cancro colorretal em Portugal: da investigação à prevenção e ao tratamento"
ASPIC, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/07/03 - 2018/07/03 V BiotechHealth Symposium - Science & Co.: Bridging the Gap
Symposium
 V BiotechHealth Symposium - Science & Co.: Bridging the Gap
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/07/21 - 2017/07/21 Simpósio GABBA "Nano 2 Universe"
Symposium
 GABBA Symposium 2017 "Nano 2 Universe"
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/07/04 - 2017/07/04 IV BiotechHealth Annual Symposium - Spotting the Differences: Biotechnology Driving Precison Medicine
Symposium
 IV BiotechHealth Annual Symposium - Spotting the Differences: Biotechnology Driving Precison Medicine
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/05/29 - 2017/06/01 VII Workshop on Cancer Research: biological and molecular basis (27h duration, 1 ECTS)
Workshop
 VII Workshop on Cancer Research: biological and molecular basis
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2016/05/18 - 2016/06/01 Participation in “5th Workshop in Mass Spectrometry and Carbohydrates”, “4th Workshop in Immunology” and “5th Workshop in Lipidomics” – 18 May 2016, 25 May 2016 and 1 June 2016
Workshop
 Workshops “5th Workshop in Mass Spectrometry and Carbohydrates”, “4th Workshop in Immunology” and “5th Workshop in Lipidomics”
Universidade de Aveiro, Portugal
2016/04/20 - 2016/04/20 VIII Biochemistry Day
Symposium
 VIII Biochemistry Day
Universidade de Aveiro, Portugal
2016/02/10 - 2016/02/11 Seminários de cromatografia líquida e gasosa, dirigidos pelo director técnico da "Tecnocroma" Rafael Chust
Seminar
 Liquid Chromatography (HPLC) and Gas Chromatography (GC) seminars
Universidade de Aveiro, Portugal
2015/06/03 - 2015/06/03 Participation in the "Workshop X-CHROMA 2015 - Utilizing metabolomics to understand biological systems"
Workshop
 Workshop X-CHROMA 2015 - Utilizing metabolomics to understand biological systems
Universidade de Aveiro, Portugal
2015/05/06 - 2015/05/20 Participation in "4th Workshop in Lipidomics", "4th Workshop in Mass Spectrometry and Carbohydrates" and "3rd Workshop in Immunology" - 6 May 2015, 13 May 2015 and 20 May 2015
Workshop
 "4th Workshop in Lipidomics", "4th Workshop in Mass Spectrometry and Carbohydrates", "3rd Workshop in Immunology"
Universidade de Aveiro, Portugal

Association member

Society Organization name Role
2021 - Current European Association for Cancer Research (EACR) Member
2021 - Current Associação Portuguesa de Investigação em Cancro (ASPIC) Member
Distinctions

Award

2015 Best poster of the 1st year of Master's degree exposed in the “7th Biochemistry Day, Biochemistry and well-being”
Universidade de Aveiro, Portugal