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Fernando José Nunes Antunes. ------EDUCATION------ Completed the Doutoramento in Bioquímica in 1997 by Universidade de Lisboa and Licenciatura in Bioquímica in 1992/09/30 by Universidade de Lisboa Faculdade de Ciências. ------CURRENT POSITIONS------ Is Co-founder of spin-off Delox in Universidade de Lisboa Faculdade de Ciências, Associate Editor Cellular Biochemistry in Frontiers Media SA, Member of the Observatory SME Expert Group for the European Observatory on Infringements of Intellectual Property Rights in European Union Intellectual Property Office, Member of the Coordination Committee of the Department of Chemistry and Biochemistry in Universidade de Lisboa Faculdade de Ciências, Associate Professor in Universidade de Lisboa Faculdade de Ciências. Organic Unit Director in Universidade de Lisboa Centro de Química Estrutural, Board Member and Executive Committee in FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências. ------OUTPUTS------ Published 81 articles in journals. H-index=36 with with 7500 citations. Has 1 section of books and 1 book. Has 2 patents registered. Organized 5 events. Participated in 4 events. Supervised 3 PhD theses e co-supervised 2. Supervised 11 MSc dissertations. Supervised 3 works of course completion of LSc/BSc e co-supervised 3. Has received 8 awards and/or honors. Participates and/or participated as Principal investigator in 4 projects, Researcher in 6 projects and Technical development in 3 projects. ------MAIN RESEARCH PROJECTS------ Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry, Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry and Engineering and Technology with emphasis on Medical Engineering. 2018- Development of a new heat-based biomarker for cellular therapies; 2015- Development of porous materials for small molecule delivery in biology; 2012- Mathematical modeling of thiol redox signaling ; 2002-2010 Biological adaptation and signaling induced by oxidation; 1998-2002 Sensitivity of T-cells to apoptotic agents: T-cells apoptosis is sensitive to iron levels, but T-cells can buffer large intracellular thiol redox changes; 1992-1997 Computer simulation of mitochondrial lipid peroxidation. -----DISTINTIONS---- Prémio Científico Universidade de Lisboa/Caixa Geral de Depósitos (“Menção Honrosa”); BfK - Born from Knowledge Award; Seal of Excellence - Accelerator Pilot -----KEYWORDS----- In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Kinetics; Mathematical models; Automatic bio-decontamination; Hydrogen peroxide vaporization; Hydrogen peroxide; Biological adaptation; Nitric oxide; Redox signaling; Thermodynamics.
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Identification

Personal identification

Full name
Fernando José Nunes Antunes

Citation names

  • Antunes, Fernando

Author identifiers

Ciência ID
711F-5E50-5F05
ORCID iD
0000-0002-4192-2840

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biochemistry
  • Engineering and Technology - Medical Engineering

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Proficiency (C2) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
French Elementary (A2) Elementary (A2) Elementary (A2) Intermediate (B1) Beginner (A1)
Italian Intermediate (B1) Intermediate (B1) Intermediate (B1) Upper intermediate (B2) Elementary (A2)
Education
Degree Classification
1997
Concluded
 Bioquímica (Doutoramento)
Major in Especialidade: Bioquímica Teórica
Universidade de Lisboa, Portugal
"Integrative Modelling of Lipid Peroxidation in Vivo" (THESIS/DISSERTATION)
1992/09/30
Concluded
 Bioquímica (Licenciatura)
Major in Não Aplicável
Universidade de Lisboa Faculdade de Ciências, Portugal
Affiliation

Science

Category
Host institution 		Employer
2000/08/01 - 2001/01/31 Contracted Researcher (Research) University of Southern California, United States
University of Southern California, United States
1997/08/01 - 2000/07/31 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
University of Southern California, United States
1996/02/01 - 1996/07/31 Invited Auxiliary Researcher (Research) JNICT, Portugal
Mount Allison University, Canada

Teaching in Higher Education

Category
Host institution 		Employer
2023/06/01 - Current Full Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
2016/05/27 - 2023/05/31 Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2019 Associate Professor (University Teacher) Universidade de Lisboa, Portugal
2013 - 2016 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
2006 - 2016 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal

Positions / Appointments

Category
Host institution 		Employer
2022/07/01 - Current Board Member and Executive Committee FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
2020/09 - Current Member of the Coordination Committee of the Department of Chemistry and Biochemistry Universidade de Lisboa Faculdade de Ciências, Portugal
2019/02/01 - Current Member of the Observatory SME Expert Group for the European Observatory on Infringements of Intellectual Property Rights European Union Intellectual Property Office, Spain
2013 - Current Associate Editor Cellular Biochemistry Frontiers Media SA, Switzerland
2022/01/01 - 2023/12/31 Organic Unit Director Universidade de Lisboa Centro de Química Estrutural, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/01/01 - 2021/12/31 Member of the Executive Committee of Centro de Química Estrutural Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Centro de Química Estrutural, Portugal
2020/01/01 - 2021/12/31 Head of the Redox Biology Laboratory of Centro de Química Estrutural Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Centro de Química Estrutural, Portugal
2014 - 2015 Scientific Board Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2015 Conselho científico/técnico-científico ou orgão correspondente Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2015 Conselho científico/técnico-científico ou orgão correspondente Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2013 Member of the Executive Committee of Centro de Química e Bioquímica Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Centro de Química e Bioquímica, Portugal
2008 - 2009 Member of the Executive Committee of Centro de Química e Bioquímica Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Others

Category
Host institution 		Employer
2018/06/05 - Current Co-founder of spin-off Delox Universidade de Lisboa Faculdade de Ciências, Portugal
DELOX - INVESTIGAÇÃO, PROCESSOS E EQUIPAMENTOS CIENTÍFICOS, LDA, Portugal
Projects

Grant

Designation Funders
2021/01/01 - 2025/12/31 Bench to Bedside transition for Pharmacological regulation of NRF2 in non-communicable diseases
CA20121
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal
 European Commission
Ongoing
2023/01/01 - 2024/06/30 Microcalorimetry and fluorescence nanothermometry in early detection of immune T-cell exhaustion
2022.06098.PTDC
Principal investigator
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/06/01 - 2020/11/30 Recycle
LISBOA-01-02B7-FEDER-055168
Technical development
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundo Europeu de Desenvolvimento Regional
Concluded
2020/05/16 - 2020/08/15 REUSE: Bio-decontamination of filtering facepiece respirators and masks for reuse
113_596701686
Principal investigator
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2010/01 - 2013/06 H2O2 role in endothelial function as a modulator of histone post-translational modifications
Provided by PTCRIS: 101624
101624
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2010/01 - 2013/06 Studies on the regulation of plasma membrane by hydrogen peroxide in Saccharomyces cerevisiae: role of lipid rafts and Pil1p
Provided by PTCRIS: 104311
104311
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2009/01 - 2012/06 Acquired resistance to cancer chemotherapy: down-regulation of plasma membrane permeability by hydrogen peroxide induces multi-drug resistance
Provided by PTCRIS: 69466
69466
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
2008/01 - 2011/12 Reconstruction and systems analysis of the reaction networks of reactive oxygen, nitrogen and sulfur species in representative physiological systems
70523
Provided by PTCRIS: 70523
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2007/01 - 2008/03 A novel mechanism for cell protection against oxidative stress: regulation of plasma membrane permeability by H2O2.
82125
Provided by PTCRIS: 82125
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2005/04 - 2007/06 A novel mechanism for cell protection against oxidative stress: regulation of plasma membrane permeability by H2O2.
Provided by PTCRIS: 59925
59925
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2003/03/01 - 2006/02/28 RESISTÊNCIA ADQUIRIDA NA TERAPIA DO CANCRO. FUNÇÃO DO STRESS OXIDATIVO E DA ACTIVAÇÃO DO NF-KB
SFRH/BPD/11487/2002
 Fundação para a Ciência e a Tecnologia
Concluded
2002 - 2005 NF-kB activation by H2O2 : mechanism, physiological relevance and cancer therapy
POCTI/BCI/42245/2001
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
1997/08/01 - 2000/07/31 PRODUÇÃO DE RADICAIS PELO MITOCÔNDRIO E DANO OXIDATIVO AO DNA MITOCONDRIAL
PRAXIS XXI/BPD/11778/97
 Fundação para a Ciência e a Tecnologia
Concluded
1996/04/01 - 1997/03/31 ESTUDO TEÓRICO-EXPERIMENTAL DA DINÂMICA DE PEROXIDAÇÃO LIPÍDICA E DOS PROCESSOS ANTIOXIDANTES ASSOCIADOS
PRAXIS XXI/BD/5575/95
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/07/05 - Current CBIODE .: CBIODE - Compact BIO Decontamination Everywhere
LISBOA-01-0247-FEDER-072326
Technical development
Universidade de Lisboa Centro de Química e Bioquímica, Portugal
 FEDER (Programa Operacional Regional de Lisboa)
Concluded
2021/01/01 - 2025/12/31 Institute of Molecular Sciences
LA/P/0056/2020
10.54499/LA/P/0056/2020
Universidade de Lisboa Centro de Química Estrutural, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade do Porto Centro de Investigação em Química, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Coimbra, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Coimbra Centro de Investigação em Antropologia e Saúde, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/02/01 - 2024/07/31 Nitric Oxide and Hydrogen Sulfide dual delivery from nanoporous materials
2022.05605.PTDC
10.54499/2022.05605.PTDC
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Centro de Recursos Naturais e Ambiente, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2022/09/30 Delivery vehicles of therapeutic gasotransmitters NO and H2S based on nanoporous materials
PTDC/MED-QUI/28721/2017
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Aveiro, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2020/06/30 Delox - Faculty of Sciences of the University of Lisbon
Selection Campaign #53
Technical development
European Space Agency Business Incubator Portugal, Portugal
 European Space Agency Business Incubator Portugal
Ongoing
2019/01/01 - 2019/12/31 Center of Chemistry and Biochemistry
UID/Multi/00612/2019
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Institute of Biophysics and Biomedical Engineering (IBEB)
UID/BIO/00645/2019
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Instituto de Biofísica e Engenharia Biomédica, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 H2O2 role in endothelial function as a modulator of histone post-translational modifications
PTDC/BIA-PRO/101624/2008
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Studies on the regulation of plasma membrane by hydrogen peroxide in Saccharomyces cerevisiae: role of lipid rafts and Pil1p
PTDC/QUI-BIQ/104311/2008
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - UI 612 - 2011-2012
PEst-OE/QUI/UI0612/2011
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012/06/30 Acquired resistance to cancer chemotherapy: down-regulation of plasma membrane permeability by hydrogen peroxide induces multi-drug resistance
PTDC/QUI/69466/2006
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/12/31 Reconstruction and systems analysis of the reaction networks of reactive oxygen, nitrogen and sulfur species in representative physiological systems
PTDC/QUI/70523/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universitat de Lleida, Spain

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/04/01 - 2007/06/30 A novel mechanism for cell protection against oxidative stress: regulation of plasma membrane permeability by H2O2.
POCI/BIA-MIC/59925/2004
Universidade de Lisboa Faculdade de Ciências, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Gomes, A.Q.; Real, C.; Antunes, F.; Marinho, H.S.; Nolasco, S.; Soares, H.. Noncoding RNAs as Critical Players in Regulatory Accuracy, Redox Signaling, and Immune Cell Functions. 2016.
    10.1016/B978-0-444-63660-7.00010-3
  2. De Oliveira-Marques, V.; Susana Marinho, H.; Cyrne, L.; Antunes, F.. Steady-state titration with H2O2: Regulation of plasma membrane permeability and of NF-¿B activation by H2O2. 2007.
Book chapter
  1. Laura de Cubas; Fernando Antunes; Olga Lyublinskaya; Elena Hidalgo. "Use of Genetically Encoded Reporters to Quantify Intracellular H2O2 Levels in Eukaryotic Cells". 2023.
    10.1201/9781003160649-5
  2. Fernando Antunes; Armindo Salvador. "How Gradients and Microdomains Determine H2O2 Redox Signaling". 2023.
    10.1201/9781003160649-2
  3. Antunes, Fernando; Brito, Paula. "Data Processing to Probe the Cellular Hydrogen Peroxide Landscape". In Computational Methods for Estimating the Kinetic Parameters of Biological Systems, 153-160. Springer US, 2021.
    Published • 10.1007/978-1-0716-1767-0_8
Journal article
  1. Carvalho, Sílvia; Pinto, Rosana V.; Pires, João; Rocha, João; Antunes, Fernando; Pinto, Moisés L.. "Evaluation of the H2S and NO adsorption and release capacity of PEG-zeolites and PEG-titanosilicates composites". Microporous and Mesoporous Materials 350 (2023): 112432. http://dx.doi.org/10.1016/j.micromeso.2023.112432.
    Published • 10.1016/j.micromeso.2023.112432
  2. Pinto, Rosana V.; Carvalho, Sílvia; Antunes, Fernando; Pires, João; Pinto, Moisés L.. "Development of Polycaprolactone–Zeolite Nanoporous Composite Films for Topical Therapeutic Release of Different Gasotransmitters". ACS Applied Nano Materials 5 7 (2022): 9230-9240. http://dx.doi.org/10.1021/acsanm.2c01591.
    10.1021/acsanm.2c01591
  3. Pinto, Rosana V.; Carvalho, Sílvia; Antunes, Fernando; Pires, João; Pinto, Moisés L.. "Emerging Nitric Oxide and Hydrogen Sulfide Releasing Carriers for Skin Wound Healing Therapy". ChemMedChem 17 1 (2021): http://dx.doi.org/10.1002/cmdc.202100429.
    10.1002/cmdc.202100429
  4. Lin, Zhi; Pinto, Rosana V.; Henriques, Carlos; Antunes, Fernando; Pires, João; Pinto, Moisés L.; Rocha, João. "Improved therapeutic nitric oxide delivery by microporous Cu-bearing titanosilicate". Microporous and Mesoporous Materials 322 (2021): 111154. http://dx.doi.org/10.1016/j.micromeso.2021.111154.
    10.1016/j.micromeso.2021.111154
  5. Fernandes, Ana C.; Pinto, Rosana; Carvalho, Sílvia; Mafra, Luís; Rocha, João; Pinto, Moisés; Antunes, Fernando; Pires, João. "Storage and delivery of H2S by microporous and mesoporous materials". Microporous and Mesoporous Materials 320 (2021): 111093. http://dx.doi.org/10.1016/j.micromeso.2021.111093.
    10.1016/j.micromeso.2021.111093
  6. Bento, Rafael; Marques, Cátia; Bernardes, Carlos; Justino, Gonçalo; Piedade, Manuel; Antunes, Fernando. "Metabolic Pathway Deficiencies are Compensated by Higher Energy Dissipation to Maintain Microbiological Growth rate in Saccharomyces cerevisiae". Free Radical Biology and Medicine 159 (2020): S64. http://dx.doi.org/10.1016/j.freeradbiomed.2020.10.170.
    Published • 10.1016/j.freeradbiomed.2020.10.170
  7. Antunes, Fernando. "Tuning Cellular Biological Functions Through the Controlled Release of NO from a Porous Ti-MOF". Angewandte Chemie International Edition 59 13 (2020): 5135-5143. http://dx.doi.org/10.1002/anie.201913135.
    Published • 10.1002/anie.201913135
  8. Claudia Rodrigues; Catarina Pimpão; Andreia F. Mósca; Ana S. Coxixo; Duarte Lopes; Inês Vieira da Silva; Per Amstrup Pedersen; Fernando Antunes; Graça Soveral. "Human Aquaporin-5 Facilitates Hydrogen Peroxide Permeation Affecting Adaption to Oxidative Stress and Cancer Cell Migration". Cancers (2019): https://doi.org/10.3390/cancers11070932.
    10.3390/cancers11070932
  9. Lyublinskaya, O.; Antunes, F.. "Measuring intracellular concentration of hydrogen peroxide with the use of genetically encoded H 2 O 2 biosensor HyPer". Redox Biology 24 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85064702290&partnerID=MN8TOARS.
    10.1016/j.redox.2019.101200
  10. Pinto, R.V.; Fernandes, A.C.; Antunes, F.; Lin, Z.; Rocha, J.; Pires, J.; Pinto, M.L.. "New generation of nitric oxide-releasing porous materials: Assessment of their potential to regulate biological functions". Nitric Oxide - Biology and Chemistry 90 (2019): 29-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-85066980131&partnerID=MN8TOARS.
    10.1016/j.niox.2019.05.010
  11. Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; et al. "Corrigendum to “European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” (Redox Biol. (2017) 13 (94–162)(S2213231717303373)(10.1016/j.redox.2017.05.007))". Redox Biology 14 (2018): 694-696. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032289195&partnerID=MN8TOARS.
    10.1016/j.redox.2017.10.001
  12. Bento, R.N.; Rendas, M.A.; Bernardes, C.E.S.; Santos, M.S.C.S.; Antunes, F.; Minas da Piedade, M.E.. "Kinetics of the base catalysed hydrolysis of methyl paraben revisited: Implications for determination of the effective volume of flow-microcalorimeters used to study cell cultures". Thermochimica Acta 659 (2018): 82-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034845884&partnerID=MN8TOARS.
    10.1016/j.tca.2017.11.008
  13. Domènech, A.; Ayté, J.; Antunes, F.; Hidalgo, E.. "Using in vivo oxidation status of one- and two-component redox relays to determine H2O2 levels linked to signaling and toxicity". BMC Biology 16 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85047999848&partnerID=MN8TOARS.
    10.1186/s12915-018-0523-6
  14. Rosana V. Pinto; Fernando Antunes; João Pires; Vanessa Graça; Paula Brandão; Moisés L. Pinto. "Vitamin B3 metal-organic frameworks as potential delivery vehicles for therapeutic nitric oxide". Acta Biomaterialia (2017):
    10.1016/j.actbio.2017.01.039
  15. Egea, Javier; Fabregat, Isabel; Frapart, Yves M.; Ghezzi, Pietro; Gorlach, Agnes; Kietzmann, Thomas; Kubaichuk, Kateryna; et al. "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)". Redox Biology 13 (2017): 94-162. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000410470000009&KeyUID=WOS:000410470000009.
    10.1016/j.redox.2017.05.007
  16. Antunes, Fernando; Brito, Paula Matos. "Quantitative biology of hydrogen peroxide signaling". Redox Biology 13 (2017): 1-7. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000410470000001&KeyUID=WOS:000410470000001.
    10.1016/j.redox.2017.04.039
  17. Antunes, Fernando. "Rat Aquaporin-5 Is pH-Gated Induced by Phosphorylation and Is Implicated in Oxidative Stress". International Journal of Molecular Sciences (2016): http://www.mdpi.com/1422-0067/17/12/2090.
    10.3390/ijms17122090
  18. Guerreiro, P.S.; Estácio, S.G.; Antunes, F.; Fernandes, A.S.; Pinheiro, P.F.; Costa, J.G.; Castro, M.; et al. "Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1". Chemical Biology and Drug Design 88 6 (2016): 915-925. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987862345&partnerID=MN8TOARS.
    10.1111/cbdd.12826
  19. Netto, L.E.S.; Antunes, F.. "The Roles of peroxiredoxin and thioredoxin in hydrogen peroxide sensing and in signal transduction". Molecules and Cells 39 1 (2016): 65-71. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975263534&partnerID=MN8TOARS.
    10.14348/molcells.2016.2349
  20. Bento, R.N.; Rendas, M.A.; Semedo, V.A.R.; Bernardes, C.E.S.; Santos, M.S.C.S.; Diogo, H.P.; Antunes, F.; Minas da Piedade, M.E.. "The standard molar enthalpy of the base catalysed hydrolysis of methyl paraben revisited". Journal of Chemical Thermodynamics 103 (2016): 176-180. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982134902&partnerID=MN8TOARS.
    10.1016/j.jct.2016.07.042
  21. Pinto, M.L.; Fernandes, A.C.; Antunes, F.; Pires, J.; Rocha, J.. "Storage and delivery of nitric oxide by microporous titanosilicate ETS-10 and Al and Ga substituted analogues". Microporous and Mesoporous Materials 229 (2016): 83-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964199540&partnerID=MN8TOARS.
    10.1016/j.micromeso.2016.04.021
  22. Ana C. Fernandes; Moisés L. Pinto; Fernando Antunes; João Pires; Fernandes, A.C.; Pinto, M.L.; Antunes, F.; Pires, J.. "l-Histidine-based organoclays for the storage and release of therapeutic nitric oxide". Journal of Materials Chemistry B 3 17 (2015): 3556-3563. https://doi.org/10.1039/C4TB01913J.
    10.1039/C4TB01913J
  23. Benfeitas, Rui; Selvaggio, Gianluca; Antunes, Fernando; Coelho, Pedro M. B. M.; Salvador, Armindo. "Hydrogen peroxide metabolism and sensing in human erythrocytes: A validated kinetic model and reappraisal of the role of peroxiredoxin II". Free Radical Biology and Medicine 74 (2014): 35-49.
    10.1016/j.freeradbiomed.2014.06.007
  24. Marinho, H Susana; Real, Carla; Cyrne, Luisa; Soares, Helena; Antunes, Fernando. "Hydrogen peroxide sensing, signaling and regulation of transcription factors.". Redox biology 2 (2014): 535-62.
    10.1016/j.redox.2014.02.006
  25. Pinto, M.L.; Fernandes, A.C.; Rocha, J.; Ferreira, A.; Antunes, F.; Pires, J.. "Microporous titanosilicates Cu2+- and Co2+-ETS-4 for storage and slow release of therapeutic nitric oxide". Journal of Materials Chemistry B 2 2 (2014): 224-230. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890074525&partnerID=MN8TOARS.
    10.1039/c3tb20929f
  26. Soares, H.; Marinho, H.S.; Real, C.; Antunes, F.. "Cellular polarity in aging: Role of redox regulation and nutrition Topical Collection on Ageing". Genes and Nutrition 9 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84893673096&partnerID=MN8TOARS.
    10.1007/s12263-013-0371-5
  27. Brito, P.M.; Antunes, F.. "Estimation of kinetic parameters related to biochemical interactions between hydrogen peroxide and signal transduction proteins". Frontiers in Chemistry 2 OCT (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84949283967&partnerID=MN8TOARS.
    10.3389/fchem.2014.00082
  28. Fernandes, A.C.; Antunes, F.; Pires, J.. "Sepiolite based materials for storage and slow release of nitric oxide". New Journal of Chemistry 37 12 (2013): 4052-4060. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887832017&partnerID=MN8TOARS.
    10.1039/c3nj00452j
  29. Marinho, H.S.; Cyrne, L.; Cadenas, E.; Antunes, F.. "H2O2 delivery to cells: Steady-state versus bolus addition". Methods in Enzymology 526 (2013): 159-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879760966&partnerID=MN8TOARS.
    10.1016/B978-0-12-405883-5.00010-7
  30. Fernandes, A.C.; Pinto, M.L.; Antunes, F.; Pires, J.. "Clay based materials for storage and therapeutic release of nitric oxide". Journal of Materials Chemistry B 1 26 (2013): 3287-3294. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880149196&partnerID=MN8TOARS.
    10.1039/c3tb20535e
  31. Marinho, H.S.; Cyrne, L.; Cadenas, E.; Antunes, F.. "The cellular steady-state of H2O2: Latency concepts and gradients". Methods in Enzymology 527 (2013): 3-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879766479&partnerID=MN8TOARS.
    10.1016/B978-0-12-405882-8.00001-5
  32. Cyrne, L.; Oliveira-Marques, V.; Marinho, H.S.; Antunes, F.. "H2O2 in the induction of NF-¿B-dependent selective gene expression". Methods in Enzymology 528 (2013): 173-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880298723&partnerID=MN8TOARS.
    10.1016/B978-0-12-405881-1.00010-0
  33. Covas, G.; Marinho, H.S.; Cyrne, L.; Antunes, F.. "Activation of Nrf2 by H2O2: De novo synthesis versus nuclear translocation". Methods in Enzymology 528 (2013): 157-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879739820&partnerID=MN8TOARS.
    10.1016/B978-0-12-405881-1.00009-4
  34. Rodrigues, J.R.; Ferrer, R.; Gamboa, N.; Charris, J.; Antunes, F.. "Potential antitumour and pro-oxidative effects of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate (QNACR)". Journal of Enzyme Inhibition and Medicinal Chemistry 28 6 (2013): 1300-1306. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887442078&partnerID=MN8TOARS.
    10.3109/14756366.2012.736385
  35. Oliveira-Marques, V.; Silva, T.; Cunha, F.; Covas, G.; Marinho, H.S.; Antunes, F.; Cyrne, L.. "A quantitative study of the cell-type specific modulation of c-Rel by hydrogen peroxide and TNF-a". Redox Biology 1 1 (2013): 347-352. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880619096&partnerID=MN8TOARS.
    10.1016/j.redox.2013.05.004
  36. Pedroso, N.; Gomes-Alves, P.; Marinho, H.S; Brito, V.B.; Boada, C.; Antunes, F.; Herrero, E.; Penque, D.; Cyrne, L.. "The plasma membrane-enriched fraction proteome response during adaptation to hydrogen peroxide in Saccharomyces cerevisiae". Free Radical Research 46 10 (2012): 1267-1279. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866309006&partnerID=MN8TOARS.
    10.3109/10715762.2012.704997
  37. Rodrigues, J.R.; Charris, J.; Camacho, J.; Barazarte, A.; Gamboa, N.; Antunes, F.. "Cytotoxic effects of N'- formyl-2-(5-nitrothiophen-2-yl) benzothiazole-6-carbohydrazide in human breast tumor cells by induction of oxidative stress". Anticancer Research 32 7 (2012): 2721-2726. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865692576&partnerID=MN8TOARS.
  38. Baptista, M.; Silveira, A.; Antunes, F.. "Theoretical analysis of the kinetic performance of laboratory- and full-scale composting systems". Waste Management and Research 30 7 (2012): 700-707. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863534765&partnerID=MN8TOARS.
    10.1177/0734242X11433528
  39. Silva, A.; Gírio, A.; Cebola, I.; Santos, C.I.; Antunes, F.; Barata, J.T.. "Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells". Leukemia 25 6 (2011): 960-967. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958125269&partnerID=MN8TOARS.
    10.1038/leu.2011.56
  40. Aresta-Branco, F.; Cordeiro, A.M.; Marinho, H.S.; Cyrne, L.; Antunes, F.; De Almeida, R.F.M.. "Gel domains in the plasma membrane of Saccharomyces cerevisiae: Highly ordered, ergosterol-free, and sphingolipid-enriched lipid rafts". Journal of Biological Chemistry 286 7 (2011): 5043-5054. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953152147&partnerID=MN8TOARS.
    10.1074/jbc.M110.154435
  41. Matias, A.C.; Marinho, H.S.; Cyrne, L.; Herrero, E.; Antunes, F.. "Biphasic modulation of fatty acid synthase by hydrogen peroxide in Saccharomyces cerevisiae". Archives of Biochemistry and Biophysics 515 1-2 (2011): 107-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053996136&partnerID=MN8TOARS.
    10.1016/j.abb.2011.08.009
  42. Baptista, M.; Antunes, F.; Silveira, A.. "Diagnosis and optimization of the composting process in full-scale mechanical-biological treatment plants". Waste Management and Research 29 6 (2011): 565-573. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959385436&partnerID=MN8TOARS.
    10.1177/0734242X10388061
  43. Cyrne, L.; Antunes, F.; Sousa-Lopes, A.; Diaz-Bérrio, J.; Marinho, H.S.. "Glyceraldehyde-3-phosphate dehydrogenase is largely unresponsive to low regulatory levels of hydrogen peroxide in Saccharomyces cerevisiae". BMC Biochemistry 11 1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78650574149&partnerID=MN8TOARS.
    10.1186/1471-2091-11-49
  44. Baptista, M.; Antunes, F.; Gonçalves, M.S.; Morvan, B.; Silveira, A.. "Composting kinetics in full-scale mechanical-biological treatment plants". Waste Management 30 10 (2010): 1908-1921. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956267560&partnerID=MN8TOARS.
    10.1016/j.wasman.2010.04.027
  45. Antunes, F.; Han, D.. "Redox regulation of NF-¿B: From basic to clinical research". Antioxidants and Redox Signaling 11 9 (2009): 2055-2056. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949199779&partnerID=MN8TOARS.
    10.1089/ars.2009.2659
  46. Pedroso, N.; Matias, A.C.; Cyrne, L.; Antunes, F.; Borges, C.; Malhó, R.; de Almeida, R.F.M.; Herrero, E.; Marinho, H.S.. "Modulation of plasma membrane lipid profile and microdomains by H2O2 in Saccharomyces cerevisiae". Free Radical Biology and Medicine 46 2 (2009): 289-298. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049106123&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2008.10.039
  47. Oliveira-Marques, V.; Marinho, H.S.; Cyrne, L.; Antunes, F.. "Role of hydrogen peroxide in NF-¿B activation: From inducer to modulator". Antioxidants and Redox Signaling 11 9 (2009): 2223-2243. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949215885&partnerID=MN8TOARS.
    10.1089/ars.2009.2601
  48. Oliveira-Marques, V.; Marinho, H.S.; Cyrne, L.; Antunes, F.. "Modulation of NF-¿B-dependent gene expression by H2O 2: A major role for a simple chemical process in a complex biological response". Antioxidants and Redox Signaling 11 9 (2009): 2043-2053. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949202521&partnerID=MN8TOARS.
    10.1089/ars.2008.2279
  49. Folmer, V.; Pedroso, N.; Matias, A.C.; Lopes, S.C.D.N.; Antunes, F.; Cyrne, L.; Marinho, H.S.. "H2O2 induces rapid biophysical and permeability changes in the plasma membrane of Saccharomyces cerevisiae". Biochimica et Biophysica Acta - Biomembranes 1778 4 (2008): 1141-1147. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949119481&partnerID=MN8TOARS.
    10.1016/j.bbamem.2007.12.008
  50. Antunes, F.; Boveris, A.; Cadenas, E.. "On the biologic role of the reaction of NO with oxidized cytochrome C oxidase". Antioxidants and Redox Signaling 9 10 (2007): 1569-1579. http://www.scopus.com/inward/record.url?eid=2-s2.0-34648843079&partnerID=MN8TOARS.
    10.1089/ars.2007.1677
  51. Antunes, F.; Cadenas, E.. "The mechanism of cytochrome C oxidase inhibition by nitric oxide". Frontiers in Bioscience 12 3 (2007): 975-985. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249782874&partnerID=MN8TOARS.
    10.2741/2118
  52. Matias, A.C.; Pedroso, N.; Teodoro, N.; Marinho, H.S.; Antunes, F.; Nogueira, J.M.; Herrero, E.; Cyrne, L.. "Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2". Free Radical Biology and Medicine 43 10 (2007): 1458-1465. http://www.scopus.com/inward/record.url?eid=2-s2.0-34948834207&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2007.08.003
  53. De Oliveira-Marques, V.; Cyrne, L.; Marinho, H.S.; Antunes, F.. "Erratum: A quantitative study of NF¿B activation by H 2O2: Relevance in inflammation and synergy with TNF-a (Journal of Immunology (2007) 178, (3893-3902))". Journal of Immunology 178 10 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-34248174361&partnerID=MN8TOARS.
  54. De Oliveira-Marques, V.; Cyrne, L.; Marinho, H.S.; Antunes, F.. "A quantitative study of NF-¿B activation by H2O 2: Relevance in inflammation and synergy with TNF-a". Journal of Immunology 178 6 (2007): 3893-3902. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947265925&partnerID=MN8TOARS.
  55. Alves, R.; Antunes, F.; Salvador, A.. "Tools for kinetic modeling of biochemical networks". Nature Biotechnology 24 6 (2006): 667-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745075591&partnerID=MN8TOARS.
    10.1038/nbt0606-667
  56. Antunes, F.; Nunes, C.; Laranjinha, J.; Cadenas, E.. "Redox interactions of nitric oxide with dopamine and its derivatives". Toxicology 208 2 (2005): 207-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-13244260965&partnerID=MN8TOARS.
    10.1016/j.tox.2004.11.033
  57. Branco, M.R.; Marinho, H.S.; Cyrne, L.; Antunes, F.. "Decrease of H 2O 2 Plasma Membrane Permeability during Adaptation to H 2O 2 in Saccharomyces cerevisiae". Journal of Biological Chemistry 279 8 (2004): 6501-6506. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342325429&partnerID=MN8TOARS.
    10.1074/jbc.M311818200
  58. Sousa-Lopes, A.; Antunes, F.; Cyrne, L.; Marinho, H.S.. "Decreased cellular permeability to H 2O 2 protects Saccharomyces cerevisiae cells in stationary phase against oxidative stress". FEBS Letters 578 1-2 (2004): 152-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644288297&partnerID=MN8TOARS.
    10.1016/j.febslet.2004.10.090
  59. Antunes, F.; Boveris, A.; Cadenas, E.. "On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide". Proceedings of the National Academy of Sciences of the United States of America 101 48 (2004): 16774-16779. http://www.scopus.com/inward/record.url?eid=2-s2.0-10044230387&partnerID=MN8TOARS.
    10.1073/pnas.0405368101
  60. Antunes, F.; Marinho, H.S.; Barreto, M.C.; Pavão, M.L.; Pinto, R.E.. "Diagnosis of enzyme inhibition based on the degree of inhibition". Biochimica et Biophysica Acta - General Subjects 1624 1-3 (2003): 11-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344395586&partnerID=MN8TOARS.
    10.1016/j.bbagen.2003.08.007
  61. Zhao, M.; Antunes, F.; Eaton, J.W.; Brunk, U.T.. "Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis". European Journal of Biochemistry 270 18 (2003): 3778-3786. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141447370&partnerID=MN8TOARS.
    10.1046/j.1432-1033.2003.03765.x
  62. Han, D.; Antunes, F.; Canali, R.; Rettori, D.; Cadenas, E.. "Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol". Journal of Biological Chemistry 278 8 (2003): 5557-5563. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037458619&partnerID=MN8TOARS.
    10.1074/jbc.M210269200
  63. Culbertson, S.M.; Antunes, F.; Havrilla, C.M.; Milne, G.L.; Porter, N.A.. "Determination of the a-tocopherol inhibition rate constant for peroxidation in low-density lipoprotein". Chemical Research in Toxicology 15 6 (2002): 870-876. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035998287&partnerID=MN8TOARS.
    10.1021/tx020012t
  64. Han, D.; Antunes, F.; Daneri, F.; Cadenas, E.. "Mitochondrial superoxide anion production and release into intermembrane space". Methods in Enzymology 349 (2002): 271-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036119296&partnerID=MN8TOARS.
    10.1016/S0076-6879(02)49341-X
  65. Antunes, F.; Han, D.; Rettori, D.; Cadenas, E.. "Mitochondrial damage by nitric oxide is potentiated by dopamine in PC12 cells". Biochimica et Biophysica Acta - Bioenergetics 1556 2-3 (2002): 233-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037010847&partnerID=MN8TOARS.
    10.1016/S0005-2728(02)00365-1
  66. Antunes, F.; Han, D.; Cadenas, E.. "Relative contributions of heart mitochondria glutathione peroxidase and catalase to H2O2 detoxification in in vivo conditions". Free Radical Biology and Medicine 33 9 (2002): 1260-1267. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036828726&partnerID=MN8TOARS.
    10.1016/S0891-5849(02)01016-X
  67. Antunes, F.; Cadenas, E.; Brunk, U.T.. "Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture". Biochemical Journal 356 2 (2001): 549-555. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035366499&partnerID=MN8TOARS.
    10.1042/0264-6021:3560549
  68. Antunes, F.; Cadenas, E.. "Cellular titration of apoptosis with steady state concentrations of H2O2: Submicromolar levels of H2O2 induce apoptosis through fenton chemistry independent of the cellular thiol state". Free Radical Biology and Medicine 30 9 (2001): 1008-1018. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035341719&partnerID=MN8TOARS.
    10.1016/S0891-5849(01)00493-2
  69. Cadenas, E.; Poderoso, J.J.; Antunes, F.; Boveris, A.. "Analysis of the pathways of nitric oxide utilization in mitochondria". Free Radical Research 33 6 (2000): 747-756. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034467521&partnerID=MN8TOARS.
    10.1080/10715760000301271
  70. Antunes, F.; Cadenas, E.. "Estimation of H2O2 gradients across biomembranes". FEBS Letters 475 2 (2000): 121-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034674055&partnerID=MN8TOARS.
    10.1016/S0014-5793(00)01638-0
  71. Antunes, F.; Barclay, L.R.C.; Ingold, K.U.; King, M.; Norris, J.Q.; Scaiano, J.C.; Xi, F.. "On the antioxidant activity of melatonin". Free Radical Biology and Medicine 26 1-2 (1999): 117-128. http://www.scopus.com/inward/record.url?eid=2-s2.0-0002869641&partnerID=MN8TOARS.
    10.1016/S0891-5849(98)00168-3
  72. Antunes, F.; Barclay, L.R.C.; Vinqvist, M.R.; Pinto, R.E.. "Determination of propagation and termination rate constants by using an extension to the rotating-sector method: Application to PLPC and DLPC bilayers". International Journal of Chemical Kinetics 30 10 (1998): 753-767. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032188128&partnerID=MN8TOARS.
    10.1002/(SICI)1097-4601(1998)30:10<753::AID-KIN8>3.0.CO;2-U
  73. Ross, L.; Barclay, C.; Vinqvist, M.R.; Antunes, F.; Pinto, R.E.. "Antioxidant activity of vitamin E determined in a phospholipid membrane by product studies: Avoiding chain transfer reactions by vitamin E radicals". Journal of the American Chemical Society 119 24 (1997): 5764-5765. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030861114&partnerID=MN8TOARS.
    10.1021/ja9705856
  74. Barclay, L.R.C.; Antunes, F.; Egawa, Y.; McAllister, K.L.; Mukai, K.; Nishi, T.; Vinqvist, M.R.. "The efficiency of antioxidants delivered by liposomal transfer". Biochimica et Biophysica Acta - Biomembranes 1328 1 (1997): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030825568&partnerID=MN8TOARS.
    10.1016/S0005-2736(97)00057-6
  75. Marinho, H.S.; Antunes, F.; Pinto, R.E.. "Role of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase in thereductionof lysophospholipid hydroperoxides". Free Radical Biology and Medicine 22 5 (1997): 871-883. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031018005&partnerID=MN8TOARS.
    10.1016/S0891-5849(96)00468-6
  76. Antunes, F.; Salvador, A.; Marinho, H.S.; Alves, R.; Pinto, R.E.. "Lipid peroxidation in mitochondrial inner membranes. I. An integrative kinetic model". Free Radical Biology and Medicine 21 7 (1996): 917-943. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029908304&partnerID=MN8TOARS.
    10.1016/S0891-5849(96)00185-2
  77. Antunes, F.; Salvador, A.; Pinto, R.E.. "PHGPx and phospholipase A2/GPx: Comparative importance on the reduction of hydroperoxides in rat liver mitochondria". Free Radical Biology and Medicine 19 5 (1995): 669-677. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028991435&partnerID=MN8TOARS.
    10.1016/0891-5849(95)00040-5
  78. Salvador, A.; Antunes, F.; Pinto, R.E.. "Kinetic modelling of in vitro lipid peroxidation experiments - 'low level' validation of a model of in vivo lipid peroxidation". Free Radical Research 23 2 (1995): 151-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029355440&partnerID=MN8TOARS.
    10.3109/10715769509064029
Preprint
  1. Fadhil Musa; Raquel Nogueira; Margarida Beiral; Fernando Antunes; João Pires. "Nanoporous Materials as Carriers of Hydrogen Peroxide Vapour: a New Bio-Decontamination Technology". 2023. https://doi.org/10.26434/chemrxiv-2023-0701v.
    10.26434/chemrxiv-2023-0701v
  2. Rafael N. Bento; Miguel A. Rendas; Valdir A. R. Semedo; Cátia F. Marques; Gonçalo. C. Justino; Carlos E. S. Bernardes; Manuel E. Minas da Piedade; Fernando Antunes. "Energy dissipation in early detection of cellular responses to metabolic challenges". 2022. https://doi.org/10.1101/2022.08.03.502646.
    10.1101/2022.08.03.502646

Intellectual property

Patent
  1. Antunes, Fernando; João Pires da Silva; Fadhil Musa. 2020. "STERILIZATION PARTICLE CONTAINING A STERILIZATION MATERIAL".
    Pending
  2. Antunes, Fernando. 2019. "Release device".
    Pending
Provisional application for patent
  1. 2022. "New Ultra-Microporous Crystalline Metal Organic Frameworks Comprising Bisphosphonic Acid Ligands.".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/09/19 Delox BIOMEET 22 (encontro anual da Associação Portuguesa de Bioindústria)
(Oeiras, Portugal)
2021/09/09 Quantitative biology of H2O2 signaling Society for Free Radical Research – Europe, Webinar Series
Society for Free Radical Research – Europe
2021/03/18 Modeling of cellular hydrogen peroxide landscape 20th Biennial Meeting of SFRR International
Society for Free Radical Research International
2020/12/11 DryVHP: A new biodecontamination technology 2nd Scientific International Conference on CBRNe SICC Series 2020
(Rome, Italy)
2020/12/11 Bio-decontamination of filtering face piece respirators and masks for reuse project dissemination. 2nd Scientific International Conference on CBRNe SICC Series 2020
(Rome, Italy)
2020/10/28 Founder-Investor Fireside Chat European Angel Investment Summit
EBAN, European Commission, Enterprise Europe Network, European Investment Project Portal
2020/10/28 REUSE: from science to technology to product to people Dia da Investigação 2020
Faculdade de Ciências da Universidade de Lisboa
2019/11 Delox - Bio-decontamination for everyone, everywhere Dual-Use Research and Innovation 2019
Andalusian Agency for Innovation and Development and Andalusian node of the Enterprise Europe Network (Seville, Spain)
2019/09/16 Measuring intracellular concentration of hydrogen peroxide with the use of genetically encoded H2O2 biosensor HyPer 3rd Symposium of the SPP1710
(Santa feliu de Guixols, Spain)
2018/06/15 DryVHP: A new biodecontamination technology Raced (Risk Assessment for CB Exposure after Decontamination)
(Portugal)
2017/10 Quantitative biology of hydrogen peroxide signaling. Quantitative biology of hydrogen peroxide signaling.
French-Portuguese-Spanish Biochemical and Molecular Biology Societies (Barcelona, Spain)
2017/09 Quantitative biology of hydrogen peroxide signaling EMBO workshop Thiol oxidation in toxicity and signalling
EMBO (Sant Feliu de Guixols, Spain)
2016/11 Hydrogen peroxide as a signaling molecule SFRBM2016 Society for Free Radical Research International Biennial 18th Congress
Society for Redox Biology and Medicine (San Francisco, United States)
2016/11 Quantitative information on hydrogen peroxide signaling experiments New concepts and views in redox biology and oxidative stress research – achievements of COST Action BM1203 (EU-ROS WG/CG final Meeting)
(Eilat, Israel)
2016/11 Quantitative experiments with H2O2; new insights availabe when combined with modeling ROS in drug discovery: from target identification to redox-based therapeutics (COST Action BM1203 – Spring WG/CG Meeting 2016)
2016/09 Hydrogen peroxide as a signaling molecule FEBS Advanced Lecture Course on “Redox Regulation of Metabolic Processes"
FEBS (Spetsais, Greece)
2016/04 Redox biology in medicine: a new COST application ROS in drug discovery: from target identification to redox-based therapeutics (COST Action BM1203 – Spring WG/CG Meeting 2016)
(Lisboa, Portugal)
2015/11 Quantitative experiments with H2O2; new insights availabe when combined with modeling SFRBM2015: Pre-meeting workshop Quantitative redox biology, trending
Society for Redox Biology and Medicine. (Boston, United States)
2010/05 H2O2 as a regulator of lipid metabolism: effect on the organization of plasma membrane lipid rafts International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species
(Salamanca, Spain)
2008/07 The mechanism of cytochrome c oxidase inhibition by nitric oxide First Portuguese Forum on Computational Biology
(Lisboa, Portugal)
2007/10 Regulation of plasma membrane permeability to H2O2 during adaptation to H2O2 Society for Free Radical Research – European Region Meeting
Society for Free Radical Research – European (Vilamoura, Portugal)
2006/08 On the Mechanism and Biology of Cytochrome C Oxidase Inhibition by Nitric Oxide XIII Biennial Meeting of the International Society for Free Radical Research
(Davos, Switzerland)
2006/02 Regulation of plasma membrane permeability to H2O2 during adaptation to H2O2 Gordon Research Conference – Oxygen Radicals
Gordon Research Conference (Ventura, United States)
2005/12 Steady-state titration with H2O2: regulation of NF-kB activation and of plasma membrane permeability by H2O2 3rd Joint Meeting of the Society for Free Radical Research of Australasia & Japan
Society for Free Radical Research of Australasia & Japan (Brisbane, Australia)
2003/12 Regulation of the permeability of biomembranes to H2O2: implications for redox compartmentalization 1st Luso-Spanish Congress on Free Radicals - 6º Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine
(Coimbra, Portugal)
2001/10 Sub-micromolar [H2O2] induce apoptosis and lysosomal rupture IV Gulbenkian Autumn Meeting: Theoretical and Computational Biology
(Oeiras, Portugal)
1999/11 Cellular titration of apoptosis with steady-state concentrations of H2O2 Advances in Free Radical Biology. Oxygen 99 Satellite Symposium
(Birmingham, United States)
1997/06 Integrative mathematical modelling of peroxide metabolism in mitochondria 3º Congresso de Radicais Livres em Química, Biologia e Medicina
(Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/12/27 - Current Development of a microcalorimetry-based biomarker for T cell immunotherapy
Co-supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/09/01 - Current Deteção precoce da exaustão de linfócitos T por microcalorimetria.
Co-supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/09/01 - Current DETEÇÃO PRECOCE DA EXAUSTÃO DE LINFÓCITOS T INDUZIDA POR DEFICIÊNCIA EM GLUTAMINA POR MICROCALORIMETRIA
Supervisor
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2018/08 - Current Quantitative Traits in Metabolism Trade-offs: A Real-time Non-invasive In vivo Approach
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09/01 - 2033/02/13 Early detection of T-cell exhaustion by microcalorimetry
Supervisor
 Medical Biochemistry (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09/01 - 2022/03/24 Novel applications of vaporized hydrogen peroxide on contaminated materials and surfaces.
Supervisor
 Applied Microbiology (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/09/01 - 2022/03/24 Porous materials for the therapeutic delivery of nitric oxide.
Co-supervisor
 Chemistry (PhD)
2016 - 2016 Libertação controlada de peróxido de hidrogénio para aplicações terapêuticas e descontaminação
Supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2016 Distribuição dos recursos metabólicos entre proliferação e manutenção celular: um estudo em tempo real e in vivo por calorimetria em Saccharomyces cerevesiae
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2015 Estudo em tempo real e in vivo da regulação do metabolismo da Saccharomyces cerevisiae pelo H2O2
Supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014 Estudo Calorimétrico do efeito do H2O2 no metabolismo da Saccharomyces cerevisiae
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2008 - 2012 Modulation Of Fatty Acid Synthase And Plasma Membrane Microdomains By Hydrogen Peroxide
Supervisor
 Bioquímica (PhD)
Universidade de Lisboa, Portugal
2010 - 2011 Papel do H2O2 na resistência adquirida ao cancro: alterações na organização das biomembranas
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2011 Regulação do factor de transcrição NrF2 pelo peróxido de hidrogénio em células HeLa
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2011 Modelação cinética da formação de espécies reactivas de oxigénio (ERO) no oceano e origem dos sistemas anti-oxidantes na evolução
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2011 The physiological role of peroxiredoxin 2 in human erythrocytes. A kinetic analysis.
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2011 Resistência adquirida ao cancro: modulação negativa da permeabilidade da membrana plasmática pelo peróxido de hidrogénio induz a resistência multi-fármacos
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2011 Modelação cinética da formação de espécies reactivas de oxigénio (ERO) no oceano e origem dos sistemas anti-oxidantes na evolução
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2010 Modulation of Membrane Proteins by Hydrogen Peroxide and Their Relevance on the Regulation of Plasma Membrane Permeability
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2010 Papel do H2O2 na resistência adquirida ao cancro
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2006 - 2009 Modelling of the kinetics of municipal solid waste composting in full-sale mechanical-biological treatment plants
Co-supervisor
2005 - 2008 Regulação redox da activação do NF-¿B pelo peróxido de hidrogénio e efeitos na expressão genica
Supervisor
2003 - 2004 Titulação da expressão génica pelo H2O2 em Saccharomyces cerevisiae em crescimento exponencial
Co-supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2003 - 2004 Envolvimento do peróxido de hidrogénio na resistência à doxorubicina em células MCF-7
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2003 - 2004 Activação do NF-kB pelo H2O2: mecanismo, relevância fisiológica e terapia contra o cancro
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2003 - 2004 Activação do NF-kB pelo H2O2: mecanismo, relevância fisiológica e terapia contra o cancro
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2002 - 2003 Sobre a geração e importância de um gradiente de H2O2 em Saccharomyces cerevisiae
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2002 - 2003 Activação de NF-kB pelo H2O2 com concentrações baixas e estacionárias em células MCF-7
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2002 - 2003 Função do citoesqueleto na activação do NF-kB pelo H2O2.
Co-supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2002 - 2003 Regulação da expressão génica pelo H2O2 em Saccharomyces cerevisiae
Co-supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018 - 2018 Organizing committee of the 19th SFRRI Biennial Meeting Lisboa (2018 - 2018)
Meeting (Member of the Organising Committee)
2018 - 2018 Systems-oriented redox stress na 19th SFRRI Biennial Meeting (2018 - 2018)
Symposium (Co-organisor)
2017 - 2017 Executive committe of the FEBS3+ 1st Joint Meeting of the French-Portuguese-Spanish Biochemical and Molecular Biology Societies (2017 - 2017)
Congress (Member of the Organising Committee)
2001 - 2001 IV Gulbenkian Autumn Meeting: Theoretical and Computational Biology (2001 - 2001)
Meeting (Member of the Organising Committee)
 Instituto Gulbenkian de Ciência, Portugal
1998 - 1998 PowBioSys: International Symposium on Power-Law Modelling of Biological Systems (1998 - 1998)
Symposium (Co-organisor)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/03/28 - Current Where chemistry meets biochemistry: the case of Delox
Seminar
 Núcleo de Estudantes de Química e Bioquímica da FCUL
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/01/18 - 2022/01/18 Seminar Riscos e Benefícios dos Antioxidantes. Palestra Curso Profissional de Técnico de Análise Laboratorial- Agrupamento de escolas de Pombal
Seminar
2021 - 2022 Exhibition Collecting Covid-19 of Museu Nacional de História Natural e da Ciência Ulisboa.
Exhibition
 Collecting Covid-19
Universidade de Lisboa Museu Nacional de História Natural, Portugal
2021/10/19 - 2021/10/19 Round table discussion on the exhibition Collecting Covid-19 of Museu Nacional de História Natural e da Ciência Ulisboa. URL: https://www.youtube.com/watch?v=tvxnqr9_Be8
Round table
 Collecting Covid-19
Universidade de Lisboa Museu Nacional de História Natural, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2017 Unraveling the protection mechanisms in the radiation resistant bacterium Deinococcus radiodurans: Cross-talk between Dps proteins triggers manganese distribution as a defense strategy against oxidative stress
(Thesis) Main arguer
 Sandra Isabel Pereira dos Santos (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012 Cyanobacterial and protozoan flavodiiron proteins are nitric oxide and/or dioxygen reductases
(Thesis) Main arguer
 Vera Lúcia Faria Viola Gonçalves (PhD)
2012 Identification of mechanisms controlling the transcriptional activity of nuclear factor kappa B (NF-¿B) p65/RelA
(Thesis) Main arguer
 Nadja Pejanovic (PhD)
2011 Nitric oxide production, diffusion and inactivation in the rat brain. In vivo studies using microelectrodes
(Thesis) Main arguer
 Ricardo Miguel Oliveira dos Santos (PhD)
2009 Nitrite in nitric oxide biology in the stomach. The role of polyphenols and ethanol.
(Thesis) Main arguer
 Bruno Miguel Alves Fernandes do Gago (PhD)
2008 Characterization of Erv2p and Pdip, two thiol oxidoreductases involved in protein disulfide bond formation in the endoplasmic reticulum of Saccharomyces cerevisiae
(Thesis) Main arguer
 Andrea Lages Lino Vala (PhD)
2007 Caracterização da função do monóxido de azoto e glutationo hepáticos na sensibilidade periférica à insulina
(Thesis) Main arguer
 Maria Pedro Sucene Guarino (PhD)
2007 Superoxide defence strategies in anaerobic prokaryotes. The mechanism of superoxide reductases
(Thesis) Main arguer
 João Vieira Rodrigues (PhD)
2007 Antioxidantes com estrutura catecólica: metabolismo e relações estrutura-actividade
(Thesis) Main arguer
 José Gonçalo Deira Duarte de Campos Justino (PhD)
2007 Oxidative stress-signaling and Yap1 transactivation
(Thesis) Main arguer
 Joana Pães de Faria Monteiro (PhD)
2006 Detecção electroquímica de óxido nítrico em fatias de hipocampo de rato com microeléctrodos de fibra de carbono
(Thesis) Main arguer
 Nuno Ricardo Esteves Ferreira (Master)
2004 Towards understanding the prooxidative mechanisms of superoxide dismutase. A mathematical approach
(Thesis) Main arguer
 11. Rui Gardner Costa de Oliveira (PhD)

Conference scientific committee

Conference name Conference host
2012 - 2012 Redox Signaling and Oxidative Stress in Health and Disease Spanish Group of Free Radical Research and the Portuguese Group of Free Radicals

Consulting

Activity description Institution / Organization
2018/06/06 - Current Directly involved in scientific and technological development of automatic bio-decontamination systems. DELOX - INVESTIGAÇÃO, PROCESSOS E EQUIPAMENTOS CIENTÍFICOS, LDA, Portugal

Interview (tv / radio show)

Program Topic
2020/07/22 - 2020/07/22 Muito Barulho Para Nada ep. 5, temporada 2 Descontaminação de máscaras no âmbito da pandemia Covid-19

Journal scientific committee

Journal title (ISSN) Publisher
2022 - Current Redox Biochemistry and Chemistry Elsevier
2017 - Current Frontiers in Molecular Biosciences
2017 - Current Frontiers in Cell and Development Biology
2013 - 2017 Frontiers in Chemistry (2296-2646) Frontiers Media SA
2012 - 2014 ISRN Oxidative Medicine (2314-6400) Hindawi Limited

Other jury / evaluation

Activity description Institution / Organization
2000 - Current Reviewer for Antioxidants & Redox Signaling Mary Ann Liebert Inc, United States
2000 - Current Reviewer for Journal of Agricultural and Food Chemistry, Journal of Physical Chemistry American Chemical Society, United States
1998 - Current Regular reviewer for Biochemical Pharmacology, Archives in Biochemistry and Biophysics, Biochimica Biophysica Acta, Free Radical Biology & Medicine, Journal of Theoretical Biology, Process Biochemistry, and Redox Biology. Elsevier BV, Netherlands
2022 - 2022 Evaluation committee for Associate Research Position (Public Notice Number Prog_CQE3 /IST-ID ) Universidade de Lisboa Centro de Química Estrutural, Portugal
2021/03 - 2021/03 Evaluation committee for Prémios FCiências.ID 2020: Ciências Químicas. Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2021 Evaluation committee for Associate Research Position (FCiências.ID/2021/DL57/CQE/1 ) Universidade de Lisboa Centro de Química Estrutural, Portugal
2021 - 2021 Evaluation committee for Science Management Position (IST-ID Nº "Prog_CQE/IST-ID ) Universidade de Lisboa Centro de Química Estrutural, Portugal
2021 - 2021 Evaluation committee for attribution of seven PhD fellowships Universidade de Lisboa Centro de Química Estrutural, Portugal
2020 - 2020 Grant evaluation for Programa Proyectos de I+D Universidad de la República Comisión Sectorial de Investigación, Uruguay
2020 - 2020 Evaluation committee for permanent tenure position (Biology) at Escola Superior de Tecnologia da Saúde de Lisboa do Instituto Politécnico de Lisboa Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2020 - 2020 Evaluation committee for permanent tenure position (Chemistry) at Escola Superior de Tecnologia da Saúde de Lisboa do Instituto Politécnico de Lisboa Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2018 - 2018 Evaluation committee for permanent tenure position in the Department of Chemical Engineering, Massachusetts Institute of Technology Massachusetts Institute of Technology Department of Chemical Engineering, United States
2016 - 2016 Grant evaluator for Programa Proyectos de I+D Universidad de la República Comisión Sectorial de Investigación, Uruguay
Distinctions

Award

2022 Prémio Científico Universidade de Lisboa/Caixa Geral de Depósitos
Universidade de Lisboa, Portugal

Caixa Geral de Depositos, Portugal
2020 BfK - Born from Knowledge
Agência Nacional de Inovação SA, Portugal
2020 Seal of Excellence - Accelerator Pilot
European Innovation Council, Belgium
2016 Papers@USA 225/2016

Title

2018 Fellow - HiseedTech
HiseedTech, Portugal

Other distinction

2018 Space Exploration Masters – New Business Ideas - Sustainable Exploration Prize (second place)
European Space Agency, France

Merck KGaA, Germany

Airbus Defence and Space GmbH, Germany
2018 i3S-Hovione Capital Innovation Prize - Partner Prizes
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Hovione, Portugal
2017 ScienceIN2Business - Tec Labs
Universidade de Lisboa Faculdade de Ciências, Portugal