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Lídia M.D. Gonçalves graduated in Applied Chemistry/Biotechnology and completed her PhD on Biological Engineering (Microbiological Technology) at the New University of Lisbon in 1993. She gets 4 years post-doc fellowship (1994-96) at ITQB/IBET, working on in vitro animal cell cultures for toxicology. She worked in a pharmaceutical company to coordinate the startup and GMP validation a new immunological veterinary production industrial unit and coordinated a multidisciplinary R&D project involving different leading research institutions. She has worked at the Pilot Plant Unit (IBET, Oeiras, Portugal) involving of translating research to the clinic. She is a member of the Advanced Technologies for Drug Delivery Research Group of the Research Institute for Medicines and Pharmaceutical Sciences (iMed.ULisboa). Currently, she is Principal Investigator at Faculty of Pharmacy of University of Lisbon (FFUL). Her major research interests involve the development and in vitro/ in vivo evaluation of new biocompatible 3D systems (micro/nano structures) for drug delivery including drug stabilization, co-delivery and targeting. In particular: the modulation of vaccines formulations to enhanced mucoadhesive properties aiming the intranasal delivery; the mucoadhesion nanoparticulate for ocular drug delivery with enhanced of bioavailability; novel systems for effective DNA delivery based on biocompatible and mucoadhesive polymers; and the protective effect of complex antigen mixtures by new polymeric particulate formulations. Her scientific activity has a major leading and networking role within different research groups, where she participates in several funded research projects. Specifically, as task leader of the in vitro assays on the area of discover of new compounds namely those as p53 modulators for cancer treatment. She has supervised several Pos-Doc, PhD, master, and graduation students (>50), published 149 scientific manuscripts in scientific peer-reviewed journals (h Index (Scopus) - 33) and filled 6 patents.
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Identification

Personal identification

Full name
Lídia Maria Diogo Gonçalves

Citation names

  • Gonçalves, Lídia

Author identifiers

Ciência ID
7211-22BA-86AD
ORCID iD
0000-0002-6799-2740

Knowledge fields

  • Engineering and Technology

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Advanced (C1) Beginner (A1) Beginner (A1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
1993
Concluded
 Engenharia Biológica Tecnologia Microbiana (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Tecnologia da fermentação láctica - cinética e imobilização" (THESIS/DISSERTATION)
 Louvor e distinção por unanimidade
1986
Concluded
 Quimica Aplicada Ramo de Biotechnologia (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2019/06/19 - Current Contracted Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/02/01 - 2019/03/01 Visiting Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018 Contracted Researcher (Research) Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal
Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal
2008/02/01 - 2013/02/27 Contracted Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2002/10/02 - 2007/12/31 Researcher (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
1992/01/02 - 1994/01/31 Researcher (Research) Instituto de Biologia Experimental e Tecnológica, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2016 - 2018 Invited Assistant Professor (University Teacher) Universidade de Lisboa, Portugal
2014 - 2015 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2013/02/01 - 2019/03 Invited Assistant Professor and Visiting Researcher Universidade de Lisboa Faculdade de Farmácia, Portugal
1997/10/01 - 2002/11/01 Director of Production Depart. Laboratório Sorologico (Grupo Medinfar), Portugal
1997/10/01 - 2002/11/01 Head of Research and Development Depart. Laboratório Sorologico (Grupo Medinfar), Portugal
1994/02/01 - 1997/09/30 Post-doc Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1987/01/01 - 1992/01/01 PhD student Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1986/01/01 - 1987/01/01 Research Student Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Projects

Contract

Designation Funders
2022/01/03 - Current A novel tolerogenic liposome-based allergen immunotherapy for dogs in the horizon
EXPL/CVT-CVT/1458/2021
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/03/29 - Current Targeting mutant p53 with tryptophanol-derived small molecules
PTDC/QUI-QOR/1304/2020
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/07/01 - 2029/07/01 Vax2Muc - "Next generation vaccines against gastrointestinal mucosal pathogens, using helicobacter pylori as model pathogen"
Grant Agreement N°101080486
Researcher
European Commission Sixth Framework Programme
Ongoing
2022 - 2026 NanoTec4Perio " Innovative nanosystems with repurposed drugs for periodontal diseases' treatment
2022.06464.PTDC
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/20 - 2022/10/19 Desenvolvimento de microdispositivos flexíveis à base de microagulhas de biocimento compósito para administração transdérmica de fármacos
PTDC/BTM-MAT/29274/2017
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/04 - 2022/10/03 Mecanismos Celulares e Moleculares de Toxicidade dos Nanomateriais Ingeridos
PTDC/SAU-PUB/29481/2017
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/04 - 2022/02/03 Biomaterial funcionalizado com glicolípidos para a prevenção de infecções por cateteres
PTDC/BTM-SAL/29335/2017
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2021/09/30 Hidroxilases dos aminoácidos aromáticos AAAHs como alvo para modulação de alterações da homeostase de catecolaminas, serotonina e melatonina
PTDC/MED-QUI/29712/2017
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2021/09/30 Terapias baseadas em fármacos serotoninérgicos para diminuir o impacto da psoríase moderada a grave:da investigação académica à indústria
PTDC/MEC-DER/30198/2017
Laboratório Edol Produtos Farmacêuticos SA, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/06/01 - 2021/05/31 Abordagem Sustentável, Segura e eScalável 3S para a valorização do licopeno: conduzindo o conhecimento para uma interface academia-indústria para o tratamento tópico da inflamação
PTDC/SAU-SER/30197/2017
Associação para a Inovação e Desenvolvimento da FCT, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/06/01 - 2019/12/31 SondaDPOC. Sondas baseadas na actividade de proteases para o diagnóstico da Doença Pulmonar Obstrutiva Crónica
PTDC/BBB-BEP/2463/2014
Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/07/01 - 2019/06/30 Co-encapsulação em transportadores lipídicos nanoestruturados como uma plataforma multifuncional para o tratamento de tumores cerebrais
PTDC/CTM-NAN/2658/2014
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/03/01 - 2015/09/30 NanoPoliBiofilm - Desenvolvimento de nanopartículas poliméricas inovadoras como estratégia para o tratamento de infecções em próteses ortopédicas.
EXCL/CTM-NAN/0166/2012
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Strategic Project - UI 4013 - 2011-2012
PEst-OE/SAU/UI4013/2011
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Aplicação de nanobiomateriais para preservação estrutural e funcional da fenilalanina hidroxilase humana:
PTDC/EBB-BIO/101237/2008
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/09/01 - 2012/03/31 Metodologias integradas para o desenvolvimento de vacinas de DNA bi- e tri-valentes contra o Helycobacter pylori
PTDC/BIO/69242/2006
Universidade Católica Portuguesa, Portugal

Universidade Católica Portuguesa Campus Sintra, Portugal

Hospital do Espírito Santo EPE, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/08/01 - 2007/09/30 Proteases cisteínicas de Plasmodium chabaudi, um modelo animal para a malária humana: caracterização bioquímica e estudos de inibição.
POCI/SAU-ESP/57696/2004
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/01/01 - 2006/12/31 Nova abordagem do desenvolvimento de uma vacina anti-spreptococica através da modulação das condições de expressão, produção, purificação e formulação
POCI/BIO/59147/2004
Universidade de Lisboa Faculdade de Farmácia, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Louro, H.; Bettencourt, A.; Gonçalves, L.M.; Almeida, A.J.; João Silva, M.. Role of Nanogenotoxicology Studies in Safety Evaluation of Nanomaterials. 2015.
    10.1016/B978-0-323-32889-0.00016-9
Book chapter
  1. Bettencourt, Ana; Gonçalves, Lídia M.. "Trends in the Design and Evaluation of Polymeric Nanocarriers: The In Vitro Nano-Bio Interactions". In Nanotoxicology in Safety Assessment of Nanomaterials, 19-41. Springer International Publishing, 2022.
    10.1007/978-3-030-88071-2_2
  2. Simões, S.; Costa, A.; Faria-Silva, A.C.; Ascenso, A.; Marto, J.; Carvalheiro, M.; Gonçalves, L.M.; et al. "Sustainable valorization of food-processing industry by-products: challenges and opportunities to obtain bioactive compounds". In Valorization of Agri-Food Wastes and By-Products, 619-644. Elsevier, 2021.
    10.1016/b978-0-12-824044-1.00023-4
  3. Faria-Silva, Ana Catarina; Costa, Ana Margarida; Ascenso, Andreia; Ribeiro, Helena Margarida; Marto, Joana; Gonçalves, Lídia Maria; Carvalheiro, Manuela; Simões, Sandra. "Nanoemulsions for cosmetic products". In Nanocosmetics, 59-77. Elsevier, 2020.
    10.1016/b978-0-12-822286-7.00004-8
  4. Graça, Angélica; Gonçalves, Lídia Maria; Raposo, Sara; Ribeiro, Helena Margarida; Marto, Joana. "Ocular Lubricants Efficacy: Mucoadhesive Evaluation Using Rheological Methods". In Proceedings of the Iberian Meeting on Rheology (IBEREO 2019), 30-34. Springer International Publishing, 2019.
    10.1007/978-3-030-27701-7_7
  5. Louro, Henriqueta; Bettencourt, Ana; Gonçalves, Lídia M.; Almeida, António J.; Silva, Maria João. "Role of nanogenotoxicology studies in safety evaluation of nanomaterials". Elsevier, 2015.
  6. Lopes, A.; Gonçalves, L. M. D.; Carrondo, M. J. T.. "Evaluation of Cytotoxicity with Fish Cell Lines: A Case Study for a-Oligothiophenes (1-5 Rings)". In Animal Cell Technology, 139-143. Springer Netherlands, 1997.
    10.1007/978-94-011-5404-8_23
  7. Lopez, T.; Carrondo, M. J. T.; Gonçalves, L. M. D.. "The Effect of Cell Culture System on the Phenotypic Stability in Primary Hepatocyte Cells". In Animal Cell Technology, 145-149. Springer Netherlands, 1997.
    10.1007/978-94-011-5404-8_24
  8. Gonçalves, L. M. D.; Lopez, T.; MacDonald, C.; Grant, M. H.; Carrondo, M. J. T.. "Three-dimensional Cell Culture Systems Stabilise the Differentiation of Hepatocyte Cell Lines". In Animal Cell Technology, 115-119. Springer Netherlands, 1997.
    10.1007/978-94-011-5404-8_19
  9. Gonçalves, L. M. D.; Rodrigues, J. M.; Aunins, J. G.; Carrondo, M. J. T.. "Immobilisation of Anchorage-Independent Cells to Porous Glass Beads: Mass Transfer Phenomena in Long - Term Packed Bed Reactor". In Animal Cell Technology: Developments Towards the 21st Century, 723-728. Springer Netherlands, 1995.
    10.1007/978-94-011-0437-1_114
  10. Gonçalves, L. M. D.; Rodrigues, J. M.; Alves, P. M.; Aunins, J. G.; Carrondo, M. J. T.. "The Effect of Flow Rate on the Immobilisation of Anchorage Independent Cells to Porous Glass Beads". In Animal Cell Technology: Developments Towards the 21st Century, 717-721. Springer Netherlands, 1995.
    10.1007/978-94-011-0437-1_113
Conference abstract
  1. Martins, Manuel A.; Oliveira, Joana; Zelenovskii, Pavel; Mafra, Luís; Olhero, Susana; Gonçalves, Lídia; Bettencourt, Ana F.; Torres, Paula M. C.. "Genipin Crosslinked Chitosan Reinforced Apatite Cement as a Carrier for Local Anti-Inflammatory Drug Delivery". Paper presented in Materiais 2022, Materials Proceedings, 2022.
    10.3390/materproc2022008134
Conference paper
  1. Pinto, Fátima; Ventura, Célia; Cadete, João; Lourenço, Ana Filipa; Pedrosa, Jorge F.S.; Vital, Nádia; Pereira, Joana F.S.; et al. "Investigation of potential respiratory adverse effects of micro/nanofibrillated cellulose and cellulose nanocrystals using human lung cell lines.". 2022.
  2. Rolo, Dora; Pereira, Joana F.S; Vieira, Adriana; Roque, Rossana; Gramacho, Ana Catarina; Vital, Nádia; Matos, Paulo; et al. "Cellular, Molecular and Genotoxic Effects of Digested Titanium Dioxide Nanomaterials". 2022.
  3. Vieira, Adriana; Rolo, Dora; Vital, Nádia; Martins, Carla; Assunção, Ricardo; Alvito, Paula; Gonçalves, Lídia; et al. "Titanium dioxide nanomaterials - induced DNA damage in intestinal cells following simulated in vitro digestion". 2021.
  4. Rolo, Dora; Pereira, Joana F.S.; Matos, Paulo; Gonçalves, Lídia; Bettencourt, Ana Francisca; Jordan, Peter; Silva, Maria João; Louro, Henriqueta. "Cellular effects of Titanium Dioxide Nanoparticles in the intestine". 2021.
  5. Louro, Henriqueta; Vieira, Adriana; Gramacho, Ana Catarina; Rolo, Dora; Vital, Nádia; Martins, Carla; Assunção, Ricardo; et al. "Analysis Of The Cytotoxicity And Genotoxicity of Digested Titanium Dioxide Nanomaterials (TiO2) In Intestinal Cells". Paper presented in EMGS 2020 - Environmental Mutagenesis & Genomics Society Virtual Annual Meeting September 12-16, 2020. Environmental Genomics: Mechanisms & Approaches For Genomic Integrity, 2020.
  6. Louro, Henriqueta; Rolo, Dora; Gramacho, Ana C.; Pereira, Joana; Matos, Paulo; Jordan, Peter; Martins, Carla; et al. "Nano-bio interactions of titanium dioxide nanomaterials in the intestinal moiety after simulated digestion in vitro". 2020.
  7. Martin, Victor; Anjos, Inês; Saraiva, Ana Sofia; Zuza, Ester; Gonçalves, Lídia; Alves, Marta M.; Santos, Catarina F.; Ribeiro, Isabel A.; Bettencourt, Ana F.. "Polymeric scaffold loaded with minocycline targeting bone regeneration and prevention of infections". Paper presented in 6th IEEE Portuguese Meeting in Bioengineering ¿ ENBENG 2019, 2019.
  8. Martin, V.; Anjos, I.; Saraiva, A.S.; Zuza, E.; Gonçalves, L.; Alves, M.; Santos, C.; Ribeiro, I.; Bettencourt, A.. "Composite scaffolds for bone regeneration and infection control". 2019.
    10.1109/ENBENG.2019.8692450
  9. Gramacho, Ana Catarina; Martins, Carla; Assunção, Ricardo; Gonçalves, Lídia; Simão Bettencourt, Ana; Paula, Alvito; Silva, Maria João; Louro, Henriqueta. "Evaluation of the cytotoxicity and genotoxicity of ingested titanium dioxide nanomaterials in intestinal cells". 2019.
  10. Dias, Kamila; Louro, Henriqueta; Gonçalves, Lídia; Bettencourt, Ana; Silva, Maria João. "Assessing the Safety of Polymeric Nanoparticulated Systems developed for Drug Delivery with Human Osteoblasts". 2018.
  11. Helena M. Ribeiro; Baltazar, Diogo; Marto, Joana; Santos, Carolina; Pelicano, D; Stevic, MC; Gonçalves, Lídia. "Enhancing the topical delivery of N-acetyl-D-glucosamine: screening emulsifying systems". Paper presented in IFSCC Congress 2018, 2018.
    Published
  12. Dias, Kamila; Louro, Henriqueta; Gonçalves, Lídia; Silva, Maria João; Bettencourt, Ana. "Biocompatibility Assessment of Polymeric Nanoparticle Carriers for Drug Delivery in Human Osteoblasts". 2017.
  13. Dias, Kamila; Louro, Henriqueta; Gonçalves, Lídia; Bettencourt, Ana; Silva, Maria João. "Safety evaluation of novel polymeric nanocarriers for drug delivery using human osteoblasts". 2017.
  14. Joana Marto; Luis Pleno de Gouveia; Gonçalves, Lídia; Duarte, Aida; Pedro Pinto; Cidade Maria Teresa; Eduardo Oliveira; António J. Almeida; Helena M. Ribeiro. "Starch Pickering emulsion: a safe vehicle for topical drug delivery". Paper presented in Annual International Conference on Pharmaceutical Sciences, 2015.
    Published
  15. Caetano, Liliana Aranha; Figueiredo, Lara; Amaral, Rita; Almeida, António José; Gonçalves, Lídia Maria Diogo. "Cellular uptake of BCG-loaded chitosan microparticles and in vivo evaluation of immune response following intranasal immunisation". 2013.
  16. Aranha Caetano, L.; Figueiredo, L.; Almeida, A.J.; Gonçalves, L.M.D.; Caetano, Liliana Aranha; Figueiredo, Lara; Almeida, António J.; Gonçalves, Lídia M. D.. "Alginate-chitosan particulate delivery systems for mucosal immunization against tuberculosis". 2012.
    10.1109/ENBENG.2012.6331346
  17. Figueiredo, L.; Calado, C.C.R.; Almeida, A.J.; Gonçalves, L.M.D.. "Protein and DNA nanoparticulate multiantigenic vaccines against H. pylori: In vivo evaluation". 2012.
    10.1109/ENBENG.2012.6331366
  18. Pinto, Alexandre; Gonçalves, Lídia M.; Góis, Pedro M. P.; Santos, Maria M. M.. "a-diazo esters as cysteine proteases inhibitors". 2010.
Conference poster
  1. Ferreira da Silva, André; Gonçalves, Lídia; Fernandes, Adelaide; Almeida, António. "Optimizing a chitosan-coated PLGA nanovehicle for oral delivery of P. gingivalis antigens". Paper presented in Jornadas Científicas da Universidade de Lisboa 2023, 2023.
  2. Ferreira da Silva, André; Gonçalves, Lídia; Fernandes, Adelaide; Almeida, António. "Optimization and evaluation of chitosan-coated PLGA nanocarrier for antigen mucosal delivery". Paper presented in 14th iMed.ULisboa Meeting, 2023.
  3. Ferreira da Silva, André; Gonçalves, Lídia; Fernandes, Adelaide; Almeida, António. "Development of chitosan-coated PLGA nanoparticulate carriers for P. gingivalis lysate mucosal delivery". Paper presented in EUFEPS Annual Meeting 2023, 2023.
  4. Ferreira da Silva, André; Gonçalves, Lídia; Fernandes, Adelaide; Almeida, António. "Breaking the link between Periodontitis and Alzheimer's disease - mucosal nanovaccine against Porphyromonas gingivalis". Paper presented in 2nd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics, 2023.
  5. Ferreira da Silva, André; Gonçalves, Lídia; Fernandes, Adelaide; Almeida, António. "Oral nanovaccine against Porphyromonas gingivalis to break the link between Periodontitis and Alzheimer's disease". Paper presented in 4th SPLC-CRS Young Scientists Meeting, 2023.
  6. Ferreira da Silva, André; Gonçalves, Lídia; Fernandes, Adelaide; Almeida, António. "Nanovaccine for oral immunisation against Porphyromonas gingivalis". Paper presented in 13th iMed.ULisboa Meeting, 2022.
  7. Alexandra M. Machado; Joana Marto; Gonçalves, Lídia; Helena M. Ribeiro; Maria Graça Miguel; Vilas-Boas, Miguel; Ana Cristina Figueiredo. "Potential skin benefits of topical formulations with Portuguese honeys". Paper presented in Cosmetinnov, 2022.
  8. Basso, João; Mendes, Maria; Silva, Jessica; Cova, Tânia; Luque-Michel, Edurne; Jorge, Andreia F.; Grijalvo, Santiago; et al. "Machine learning for establishing the bridge between formulation design and performance in glioblastoma". Paper presented in 3rd SPLC-CRS Young Scientist Virtual Meeting, 2021.
  9. Vieira, Adriana; Gramacho, Ana; Rolo, Dora; Vital, Nádia; Godinho-Pereira, Joana; Matos, Paulo; Jordan, Peter; et al. "Biological effects of ingested nanomaterials and potential adverse outcomes for human health". Paper presented in Encontro Ciência 2020, 2020.
  10. Nunes, Andreia; Félix, Rita; Marto, Joana; Gonçalves, Lídia; Lopes, Francisca; Ribeiro, Helena. "Optimization of neutrophil-elastase inhibitors as anti-inflammatory agents.". Paper presented in 4rd meeting of Colégio de Química da Universidade de Lisboa - Chemistry: Shaping the Future., 2019.
  11. Pelicano, Diogo; Baltazar, Diogo; Gonçalves, Lídia; Marto, Joana; Ribeiro, Helena. "Formulation studies of innovative topical systems with N-acetyl-D-glucosamine and quercetin". Paper presented in V Congress of the Portuguese Society of Cosmetic Sciences, 2018.
  12. Carvalho, T.I.; Gonçalves, Lídia; Almeida, AJ; Roxo Rosa, Mónica; Calado, Cecília Ribeiro da Cruz. "Th1 and Th2 type epitopes cocktail, as a DNA vaccine against Helicobacter pylori.". Paper presented in Vaccine Third Global Congress, October 4 ¿ 6, Singapore, Abstract P1.31., 2009.
  13. Gonçalves, Lídia; Caldeira, R.A.; Martins, Tiago M.; do Rosário, V.E.; novo, carlos; Domingos, Ana. "Expression of soluble active recombinant chabaupain-1 from Plasmodium chabaudi". Paper presented in 5th Annual Workshop COST Action 857, Apicomplexan Biology in the post-genomic era, 2008.
Journal article
  1. Iván Lamela-Gómez; Lídia M. Gonçalves; António J. Almeida; Asteria Luzardo-Álvarez. "Infliximab microencapsulation: an innovative approach for intra-articular administration of biologics in the management of rheumatoid arthritis—in vitro evaluation". Drug Delivery and Translational Research (2023): https://doi.org/10.1007/s13346-023-01372-1.
    10.1007/s13346-023-01372-1
  2. Zegre, M.; Poljanska, E.; Caetano, L.A.; Gonçalves, L.; Bettencourt, A.. "Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone". International Journal of Pharmaceutics 648 (2023): 123584. http://dx.doi.org/10.1016/j.ijpharm.2023.123584.
  3. Valentina Sallustio; Giovanna Farruggia; Massimiliano Pio di Cagno; Martina M. Tzanova; Joana Marto; Helena Ribeiro; Lidia Maria Goncalves; et al. "Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract". Gels 9 5 (2023): 362. https://doi.org/10.3390/gels9050362.
    10.3390/gels9050362
  4. Giulia Nerli; Lídia M. D. Gonçalves; Marzia Cirri; António J. Almeida; Francesca Maestrelli; Natascia Mennini; Paola A. Mura. "Design, Evaluation and Comparison of Nanostructured Lipid Carriers and Chitosan Nanoparticles as Carriers of Poorly Soluble Drugs to Develop Oral Liquid Formulations Suitable for Pediatric Use". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041305.
    10.3390/pharmaceutics15041305
  5. Silva, Beatriz; Gonçalves, Lídia M.; São Braz, Berta; Delgado, Esmeralda. "Topical ocular delivery of nanoparticles with epoetin beta in Wistar Hannover rats". Scientific Reports 13 1 (2023): http://dx.doi.org/10.1038/s41598-023-28845-0.
    10.1038/s41598-023-28845-0
  6. Silva, Beatriz; Gonçalves, Lídia M.; Braz, Berta São; Delgado, Esmeralda; Beatriz Silva; Lídia M. Gonçalves; Berta São Braz; Esmeralda Delgado. "Topical Administration of a Nanoformulation of Chitosan-Hyaluronic Acid-Epoetin Beta in a Rat Model of Glaucoma". Pharmaceuticals 16 2 (2023): 164. http://dx.doi.org/10.3390/ph16020164.
    10.3390/ph16020164
  7. Bettencourt, Ana F.; Costa, Joana; Ribeiro, Isabel A.C.; Gonçalves, Lídia; Arias-Moliz, Maria Teresa; Dias, Juliana R.; Franco, Margarida; et al. "Development of a chlorhexidine delivery system based on dental reline acrylic resins". International Journal of Pharmaceutics 631 (2023): 122470. http://dx.doi.org/10.1016/j.ijpharm.2022.122470.
    10.1016/j.ijpharm.2022.122470
  8. Girst, Gábor; Lopes, Elizabeth A.; Gonçalves, Lídia M.; Espadinha, Margarida; Kúsz, Norbert; Wang, Hui-Chun; Santos, Maria M. M.; Hunyadi, Attila. "Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cells". RSC Medicinal Chemistry 14 9 (2023): 1778-1786. http://dx.doi.org/10.1039/d3md00251a.
  9. Dora Rolo; Ricardo Assunção; Célia Ventura; Paula Alvito; Lídia Gonçalves; Carla Martins; Ana Bettencourt; et al. "Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles—A Systematic Review". Nanomaterials (2022): https://doi.org/10.3390/nano12193275.
    10.3390/nano12193275
  10. Dardouri, Maïssa; Aljnadi, Israa M.; Deuermeier, Jonas; Santos, Catarina; Costa, Fabiola; Martin, Victor; Fernandes, Maria H.; et al. "Bonding antimicrobial rhamnolipids onto medical grade PDMS: A strategy to overcome multispecies vascular catheter-related infections". Colloids and Surfaces B: Biointerfaces 217 (2022): 112679. http://dx.doi.org/10.1016/j.colsurfb.2022.112679.
    10.1016/j.colsurfb.2022.112679
  11. Silva, Sara; Marto, Joana; Gonçalves, Lídia M.; Duarte, Diana; Soares, O. Salomé G. P.; Vasques-Nóvoa, Francisco; Almeida, António J.; et al. "New Peptide Functionalized Nanostructured Lipid Carriers with CNS Drugs and Evaluation Anti-proliferative Activity". International Journal of Molecular Sciences 23 13 (2022): 7109. http://dx.doi.org/10.3390/ijms23137109.
    10.3390/ijms23137109
  12. Ana Ruas; Angelica Graça; Joana Marto; Lídia Gonçalves; Ana Oliveira; Alexandra Nogueira da Silva; Madalena Pimentel; et al. "Chemical Characterization and Bioactivity of Commercial Essential Oils and Hydrolates Obtained from Portuguese Forest Logging and Thinning". Molecules 27 11 (2022): 3572. https://doi.org/10.3390/molecules27113572.
    Published • 10.3390/molecules27113572
  13. Zegre, M.; Barros, J.; Ribeiro, I.A.C.; Santos, C; Caetano, L.A.; Gonçalves, L.; Monteiro, F.J.; Ferraz, M.P.; Bettencourt, A.. "Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms". International Journal of Pharmaceutics 622 (2022): 121832. http://dx.doi.org/10.1016/j.ijpharm.2022.121832.
    Published • 10.1016/j.ijpharm.2022.121832
  14. Silva, Sara; Marto, Joana; Gonçalves, Lídia M.; Fernandes, Henrique S.; Sousa, Sérgio F.; Almeida, António J.; Vale, Nuno; et al. "Development of Neuropeptide Y and Cell-Penetrating Peptide MAP Adsorbed onto Lipid Nanoparticle Surface". Molecules 27 9 (2022): 2734. http://dx.doi.org/10.3390/molecules27092734.
    10.3390/molecules27092734
  15. Fátima Pinto; Ana Filipa Lourenço; Jorge F. S. Pedrosa; Lídia Gonçalves; Célia Ventura; Nádia Vital; Ana Bettencourt; et al. "Analysis of the In Vitro Toxicity of Nanocelluloses in Human Lung Cells as Compared to Multi-Walled Carbon Nanotubes". Nanomaterials 12 9 (2022): 1432. https://doi.org/10.3390/nano12091432.
    Published • 10.3390/nano12091432
  16. Vieira, Adriana; Vital, Nádia; Rolo, Dora; Roque, Rossana; Gonçalves, Lídia M.; Bettencourt, Ana; Silva, Maria João; Louro, Henriqueta. "Investigation of the genotoxicity of digested titanium dioxide nanomaterials in human intestinal cells". Food and Chemical Toxicology 161 (2022): 112841. http://dx.doi.org/10.1016/j.fct.2022.112841.
    10.1016/j.fct.2022.112841
  17. Silva, Beatriz; Gonçalves, Lídia M.; Braz, Berta São; Delgado, Esmeralda. "Chitosan and Hyaluronic Acid Nanoparticles as Vehicles of Epoetin Beta for Subconjunctival Ocular Delivery". Marine Drugs 20 2 (2022): 151. http://dx.doi.org/10.3390/md20020151.
    10.3390/md20020151
  18. Faria, Jaime; Dionísio, Bruno; Soares, Íris; Baptista, Ana Catarina; Marques, Ana; Gonçalves, Lídia; Bettencourt, Ana; Baleizão, Carlos; Ferreira, Isabel. "Cellulose acetate fibres loaded with daptomycin for metal implant coatings". Carbohydrate Polymers 276 (2022): 118733. http://dx.doi.org/10.1016/j.carbpol.2021.118733.
    10.1016/j.carbpol.2021.118733
  19. Mendes, Rita M.; Francisco, Ana P.; Carvalho, Filomena A.; Dardouri, Maissa; Costa, Bruna; Bettencourt, Ana F.; Costa, Judite; et al. "Fighting S. aureus catheter-related infections with sophorolipids: Electing an antiadhesive strategy or a release one?". Colloids and Surfaces B: Biointerfaces 208 (2021): 112057. http://dx.doi.org/10.1016/j.colsurfb.2021.112057.
    10.1016/j.colsurfb.2021.112057
  20. Nunes, Andreia; Marto, Joana; Gonçalves, Lídia; Martins, Ana Margarida; Fraga, Carmo; Ribeiro, Helena Margarida. "Potential therapeutic of olive oil industry by-products in skin health: a review". International Journal of Food Science & Technology 57 1 (2021): 173-187. http://dx.doi.org/10.1111/ijfs.15384.
    10.1111/ijfs.15384
  21. Silva, Beatriz; São Braz, Berta; Delgado, Esmeralda; Gonçalves, Lídia. "Colloidal nanosystems with mucoadhesive properties designed for ocular topical delivery". International Journal of Pharmaceutics 606 (2021): 120873. http://dx.doi.org/10.1016/j.ijpharm.2021.120873.
    Published • 10.1016/j.ijpharm.2021.120873
  22. Paulo R. Lino; João Leandro; Lara Figueiredo; Mariana P. Amaro; Lídia M. D. Gonçalves; Paula Leandro; António J. Almeida. "Systematic Modification and Evaluation of Enzyme-Loaded Chitosan Nanoparticles". International Journal of Molecular Sciences 22 15 (2021): 7987-7987. https://doi.org/10.3390/ijms22157987.
    10.3390/ijms22157987
  23. Lopes, Raquel R.; Tomé, Catarina S.; Russo, Roberto; Paterna, Roberta; Leandro, João; Candeias, Nuno R.; Gonçalves, Lídia M. D.; et al. "Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives". Biomolecules 11 3 (2021): 462. http://dx.doi.org/10.3390/biom11030462.
    10.3390/biom11030462
  24. Paulo R. Lino; João Leandro; Mariana Amaro; Lídia M. D. Gonçalves; Paula Leandro; António J. Almeida. "In Silico and In Vitro Tailoring of a Chitosan Nanoformulation of a Human Metabolic Enzyme". Pharmaceutics 13 3 (2021): 329-329. https://doi.org/10.3390/pharmaceutics13030329.
    10.3390/pharmaceutics13030329
  25. Mancini, Giuliana; Gonçalves, Lídia M. D.; Marto, Joana; Carvalho, Filomena A.; Simões, Sandra; Ribeiro, Helena Margarida; Almeida, António J.; et al. "Increased Therapeutic Efficacy of SLN Containing Etofenamate and Ibuprofen in Topical Treatment of Inflammation". Pharmaceutics 13 3 (2021): 328. http://dx.doi.org/10.3390/pharmaceutics13030328.
    Published • 10.3390/pharmaceutics13030328
  26. Margarida Espadinha; Valentina Barcherini; Lídia M. Gonçalves; Elies Molins; Alexandra M. M. Antunes; Maria M. M. Santos. "Tryptophanol-Derived Oxazolopyrrolidone Lactams as Potential Anticancer Agents against Gastric Adenocarcinoma". Pharmaceuticals 14 3 (2021): 208-208. https://doi.org/10.3390/ph14030208.
    10.3390/ph14030208
  27. Nunes, Andreia; Gonçalves, Lídia; Marto, Joana; Martins, Ana Margarida; Silva, Alexandra N.; Pinto, Pedro; Martins, Marta; Fraga, Carmo; Ribeiro, Helena Margarida. "Investigations of Olive Oil Industry By-Products Extracts with Potential Skin Benefits in Topical Formulations". Pharmaceutics 13 4 (2021): 465. http://dx.doi.org/10.3390/pharmaceutics13040465.
    10.3390/pharmaceutics13040465
  28. Sandra Cordeiro; Beatriz Silva; Ana Margarida Martins; Helena Margarida Ribeiro; Lídia Gonçalves; Joana Marto. "Antioxidant-Loaded Mucoadhesive Nanoparticles for Eye Drug Delivery: A New Strategy to Reduce Oxidative Stress". Processes 9 2 (2021): 379-379. https://doi.org/10.3390/pr9020379.
    10.3390/pr9020379
  29. Basso, João; Mendes, Maria; Silva, Jessica; Cova, Tânia; Luque-Michel, Edurne; Jorge, Andreia F.; Grijalvo, Santiago; et al. "Sorting hidden patterns in nanoparticle performance for glioblastoma using machine learning algorithms". International Journal of Pharmaceutics 592 (2021): 120095. http://dx.doi.org/10.1016/j.ijpharm.2020.120095.
    10.1016/j.ijpharm.2020.120095
  30. Saraiva, Ana S.; Ribeiro, Isabel A.C.; Fernandes, Maria H.; Cerdeira, Ana Cláudia; Vieira, Bruno J.C.; Waerenborgh, João Carlos; Pereira, Laura C.J.; et al. "3D-printed platform multi-loaded with bioactive, magnetic nanoparticles and an antibiotic for re-growing bone tissue". International Journal of Pharmaceutics 593 (2021): 120097. http://dx.doi.org/10.1016/j.ijpharm.2020.120097.
    10.1016/j.ijpharm.2020.120097
  31. Islan, Germán A.; Gonçalves, Lídia M. D.; Marto, Joana; Duarte, Aida; Alvarez, Vera A.; Castro, Guillermo R.; Almeida, António J.. "Effect of a-tocopherol on the physicochemical, antioxidant and antibacterial properties of levofloxacin loaded hybrid lipid nanocarriers". New Journal of Chemistry (2021): http://dx.doi.org/10.1039/d0nj03781h.
    10.1039/d0nj03781h
  32. Rouco, Helena; Diaz-Rodriguez, Patricia; Gaspar, Diana P.; Gonçalves, Lídia M. D.; Cuerva, Miguel; Remuñán-López, Carmen; Almeida, António J.; Landin, Mariana. "Rifabutin-Loaded Nanostructured Lipid Carriers as a Tool in Oral Anti-Mycobacterial Treatment of Crohn’s Disease". Nanomaterials 10 11 (2020): 2138. http://dx.doi.org/10.3390/nano10112138.
    10.3390/nano10112138
  33. Silva, Sara; Marto, Joana; Gonçalves, Lídia; Almeida, Anto´nio J.; Vale, Nuno. "Formulation, Characterization and Evaluation against SH-SY5Y Cells of New Tacrine and Tacrine-MAP Loaded with Lipid Nanoparticles". Nanomaterials 10 10 (2020): 2089. http://dx.doi.org/10.3390/nano10102089.
    Published • 10.3390/nano10102089
  34. Jnaidi, Raneem; Almeida, António José; Gonçalves, Lídia M.. "Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Smart Drug Delivery Systems in the Treatment of Glioblastoma Multiforme". Pharmaceutics 12 9 (2020): 860. http://dx.doi.org/10.3390/pharmaceutics12090860.
    Published • 10.3390/pharmaceutics12090860
  35. Bettencourt, Ana; Gonçalves, Lídia M.; Gramacho, Ana C.; Vieira, Adriana; Rolo, Dora; Martins, Carla; Assunção, Ricardo; et al. "Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro Digestion". Nanomaterials 10 8 (2020): 1516. http://dx.doi.org/10.3390/nano10081516.
    Published • 10.3390/nano10081516
  36. Marto, Joana; Nunes, Andreia; Martins, Ana Margarida; Carvalheira, João; Prazeres, Pedro; Gonçalves, Lídia; Marques, Alexandre; Lucas, António; Ribeiro, Helena Margarida. "Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulation". Cosmetics 7 3 (2020): 62. http://dx.doi.org/10.3390/cosmetics7030062.
    10.3390/cosmetics7030062
  37. Freitas, Rafaela; Martins, Alice; Silva, Joana; Alves, Celso; Pinteus, Susete; Alves, Joana; Teodoro, Fernando; et al. "Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications". Antioxidants 9 7 (2020): 611. http://dx.doi.org/10.3390/antiox9070611.
    10.3390/antiox9070611
  38. Espadinha, Margarida; Viejo, Lucía; Lopes, Ricardo M.R.M.; Herrera-Arozamena, Clara; Molins, Elies; dos Santos, Daniel J.V.A.; Gonçalves, Lídia; et al. "Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders". European Journal of Medicinal Chemistry 194 (2020): 112242. http://dx.doi.org/10.1016/j.ejmech.2020.112242.
    10.1016/j.ejmech.2020.112242
  39. Nunes, Andreia; Marques, Paula; Marto, Joana; Ascenso, Andreia; Gonçalves, Lídia; Fitas, Manuel; Pinto, Pedro; Sotomayor, João; Ribeiro, Helena M.. "Sugar Surfactant-Based Shampoos". Journal of Surfactants and Detergents 23 4 (2020): 809-819. http://dx.doi.org/10.1002/jsde.12415.
    10.1002/jsde.12415
  40. Nunes, Andreia; Marto, Joana; Gonçalves, Lídia Maria; Simões, Sandra; Félix, Rita; Ascenso, Andreia; Lopes, Francisca; Ribeiro, Helena Margarida. "Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management". Pharmaceutics 12 4 (2020): 358. http://dx.doi.org/10.3390/pharmaceutics12040358.
    Published • 10.3390/pharmaceutics12040358
  41. Carvalho, Luís A. R.; Almeida, Vanessa T.; Brito, José A.; Lum, Kenneth M.; Oliveira, Tânia F.; Guedes, Rita C.; Gonçalves, Lídia M.; et al. "3-Oxo-ß-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling". ACS Chemical Biology 15 4 (2020): 878-883. http://dx.doi.org/10.1021/acschembio.0c00090.
    10.1021/acschembio.0c00090
  42. Joana Couto; Artur Figueirinha; Maria Teresa Batista; António Paranhos; Carla Nunes; Lídia Maria Gonçalves; Joana Marto; et al. "Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties". Antioxidants 9 2 (2020): 154-154. https://doi.org/10.3390/antiox9020154.
    10.3390/antiox9020154
  43. Silva, Beatriz; Marto, Joana; Braz, Berta São; Delgado, Esmeralda; Almeida, António José; Gonçalves, Lídia. "New nanoparticles for topical ocular delivery of erythropoietin". International Journal of Pharmaceutics 576 (2020): 119020. http://dx.doi.org/10.1016/j.ijpharm.2020.119020.
    Published • 10.1016/j.ijpharm.2020.119020
  44. Ana Cadete; Ana Olivera; Magnus Besev; Pradeep K. Dhal; Lídia Gonçalves; António J. Almeida; Guillaume Bastiat; et al. "Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-47995-8.
    10.1038/s41598-019-47995-8
  45. Catarina Carriço; Pedro Pinto; Angélica Graça; Lídia Gonçalves; Helena Ribeiro; Joana Marto. "Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application". Pharmaceutics (2019): https://www.mdpi.com/1999-4923/11/3/131.
    10.3390/pharmaceutics11030131
  46. Joana Marto; A. Duarte; Sandra Simões; Lídia Gonçalves; Luis Gouveia; António José Almeida; Helena Ribeiro. "Starch-Based Pickering Emulsions as Platforms for Topical Antibiotic Delivery: In Vitro and In Vivo Studies". Polymers (2019): http://www.mdpi.com/2073-4360/11/1/108.
    10.3390/polym11010108
  47. Viegas, Carla; Almeida, Beatriz; Monteiro, Ana; Paciência, Inês; Rufo, João; Aguiar, Lívia; Lage, Bruna; et al. "Exposure assessment in one central hospital: a multi-approach protocol to achieve an accurate risk characterization". (2019): http://hdl.handle.net/10400.21/10717.
    10.1016/j.envres.2019.108947
  48. Martin, V.; Ribeiro, I.A.; Alves, M.M.; Gonçalves, L.; Claudio, R.A.; Grenho, L.; Fernandes, M.H.; et al. "Engineering a multifunctional 3D-printed PLA-collagen-minocycline-nanoHydroxyapatite scaffold with combined antimicrobial and osteogenic effects for bone regeneration". Materials Science and Engineering C 101 (2019): 15-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063368674&partnerID=MN8TOARS.
    10.1016/j.msec.2019.03.056
  49. Gaspar, D.P.; Vital, J.; Leiva, M.C.; Gonçalves, L.M.D.; Taboada, P.; Remuñán-López, C.; Vítor, J.; Almeida, A.J.. "Transfection of pulmonary cells by stable pDNA-polycationic hybrid nanostructured particles". Nanomedicine 14 4 (2019): 407-429. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061585165&partnerID=MN8TOARS.
    10.2217/nnm-2018-0270
  50. Martin, V.; Ribeiro, I.A.C.; Alves, M.M.; Gonçalves, L.; Almeida, A.J.; Grenho, L.; Fernandes, M.H.; et al. "Understanding intracellular trafficking and anti-inflammatory effects of minocycline chitosan-nanoparticles in human gingival fibroblasts for periodontal disease treatment". International Journal of Pharmaceutics 572 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075787156&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2019.118821
  51. Barbara S. Gregorí Valdés; Clara S. B. Gomes; Pedro T. Gomes; José R. Ascenso; Hermínio P. Diogo; Lídia Gonçalves; Rui Galhano dos Santos; Helena Ribeiro; João C. Bordado. "Synthesis and Characterization of Isosorbide-Based Polyurethanes Exhibiting Low Cytotoxicity Towards HaCaT Human Skin Cells". Polymers (2018): http://www.mdpi.com/2073-4360/10/10/1170.
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  52. Gonçalves, Lídia. "Useful In Vitro Techniques to Evaluate the Mucoadhesive Properties of Hyaluronic Acid-Based Ocular Delivery Systems". Pharmaceutics (2018): http://www.mdpi.com/1999-4923/10/3/110.
    10.3390/pharmaceutics10030110
  53. J. M. Marto; L. F. Gouveia; L. M. D. Gonçalves; H. M. Ribeiro; A. J. Almeida. "Design of minocycline-containing starch nanocapsules for topical delivery". Journal of Microencapsulation (2018): 1-13. https://doi.org/10.1080/02652048.2018.1487472.
    10.1080/02652048.2018.1487472
  54. Gonçalves, Lídia. "Rice Water: A Traditional Ingredient with Anti-Aging Efficacy". Cosmetics (2018): http://www.mdpi.com/2079-9284/5/2/26.
    10.3390/cosmetics5020026
  55. Marto, J.; Ruivo, E.; Lucas, S.D.; Gonçalves, L.M.; Simões, S.; Gouveia, L.F.; Felix, R.; et al. "Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance". European Journal of Pharmaceutics and Biopharmaceutics 127 (2018): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041571552&partnerID=MN8TOARS.
    10.1016/j.ejpb.2018.01.011
  56. Marto, J.; Pinto, P.; Fitas, M.; Gonçalves, L.M.; Almeida, A.J.; Ribeiro, H.M.. "Safety assessment of starch-based personal care products: Nanocapsules and pickering emulsions". Toxicology and Applied Pharmacology 342 (2018): 14-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041505546&partnerID=MN8TOARS.
    10.1016/j.taap.2018.01.018
  57. Woischnig, Anne Kathrin; Gonçalves, Lidia M.; Ferreira, Maxime; Kuehl, Richard; Kikhney, Judith; Moter, Annette; Ribeiro, Isabel A. C.; et al. "Acrylic microparticles increase daptomycin intracellular and in vivo anti-biofilm activity against Staphylococcus aureus". (2018): http://hdl.handle.net/10451/34957.
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  58. António, J.P.M.; Gonçalves, L.M.; Guedes, R.C.; Moreira, R.; Gois, P.M.P.. "Diazaborines as New Inhibitors of Human Neutrophil Elastase". ACS Omega 3 7 (2018): 7418-7423. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049642953&partnerID=MN8TOARS.
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  59. Ribeiro, H.M.; Allegro, M.; Marto, J.; Pedras, B.; Oliveira, N.G.; Paiva, A.; Barreiros, S.; Gonçalves, L.M.; Simões, P.. "Converting Spent Coffee Grounds into Bioactive Extracts with Potential Skin Antiaging and Lightening Effects". ACS Sustainable Chemistry and Engineering 6 5 (2018): 6289-6295. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046719180&partnerID=MN8TOARS.
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  60. Mendes, M.; Miranda, A.; Cova, T.; Gonçalves, L.; Almeida, A.J.; Sousa, J.J.; do Vale, M.L.C.; et al. "Modeling of ultra-small lipid nanoparticle surface charge for targeting glioblastoma". European Journal of Pharmaceutical Sciences 117 (2018): 255-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042853508&partnerID=MN8TOARS.
    10.1016/j.ejps.2018.02.024
  61. Santos Ferreira, I.; Kikhney, J.; Kursawe, L.; Kasper, S.; Gonçalves, L.M.D.; Trampuz, A.; Moter, A.; Bettencourt, A.F.; Almeida, A.J.. "Encapsulation in Polymeric Microparticles Improves Daptomycin Activity Against Mature Staphylococci Biofilms—a Thermal and Imaging Study". AAPS PharmSciTech 19 4 (2018): 1625-1636. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042598554&partnerID=MN8TOARS.
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  64. Caetano, L.A.; Figueiredo, L.; Almeida, A.J.; Gonçalves, L.M.D.. "BCG-loaded chitosan microparticles: interaction with macrophages and preliminary in vivo studies". Journal of Microencapsulation 34 2 (2017): 203-217. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018479413&partnerID=MN8TOARS.
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  65. Gregorí Valdes, B.S.; Serro, A.P.; Gordo, P.M.; Silva, A.; Gonçalves, L.; Salgado, A.; Marto, J.; et al. "New Polyurethane Nail Lacquers for the Delivery of Terbinafine: Formulation and Antifungal Activity Evaluation". Journal of Pharmaceutical Sciences 106 6 (2017): 1570-1577. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017369874&partnerID=MN8TOARS.
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  134. Caldeira, Rubina L.; Goncalves, Lidia M. D.; Martins, Tiago M.; Silveira, Henrique; Novo, Carlos; do Rosario, Virgilio; Domingos, Ana. "Plasmodium chabaudi". (2009): http://hdl.handle.net/10451/21317.
    http://dx.doi.org/10.1016/j.exppara.2009.03.003
  135. Capela, Rita; Oliveira, Rudi; Goncalves, Lidia M.; Domingos, Ana; Gut, Jiri; Rosenthal, Philip J.; Lopes, Francisca; Moreira, Rui. "Artemisinin-dipeptidyl vinyl sulfone hybrid molecules". (2009): http://hdl.handle.net/10451/21198.
    http://dx.doi.org/10.1016/j.bmcl.2009.04.100
  136. Florindo, Helena F.; Pandit, Sreenivas; Goncalves, Lidia M. D.; Videira, Mafalda; Alpar, Oya; Almeida, Antonio J.. "Antibody and cytokine-associated immune responses to S. equi antigens entrapped in PLA nanospheres". Biomaterials 30 28 (2009): 5161-5169. http://hdl.handle.net/10451/20980.
    http://dx.doi.org/10.1016/j.biomaterials.2009.05.045
  137. Florindo, H. F.; Pandit, S.; Goncalves, L. M. D.; Alpar, H. O.; Almeida, A. J.. "Streptococcus equi antigens adsorbed onto surface modified poly-epsilon-caprolactone microspheres induce humoral and cellular specific immune responses". Vaccine 26 33 (2008): 4168-4177.
    10.1016/j.vaccine.2008.05.074
  138. Azevedo, Ana F.; Galhardas, Jorge; Cunha, Antonio; Cruz, Patricia; Goncalves, Lidia M. D.; Almeida, Antonio J.. "Microencapsulation of Streptococcus equi antigens in biodegradable microspheres and preliminary immunisation studies". European Journal of Pharmaceutics and Biopharmaceutics 64 2 (2006): 131-137. http://hdl.handle.net/10451/20988.
    10.1016/j.ejpb.2006.04.007
  139. Araujo, CSA; Marques, SAF; Carrondo, MJT; Goncalves, LMD. "In vitro response of the brown bullhead catfish (BB) and rainbow trout (RTG-2) cell lines to benzo[a]pyrene". Science of the Total Environment 247 2-3 (2000): 127-135.
    10.1016/S0048-9697(99)00484-2
  140. Gonçalves, L.M.D.; Ramos, A.; Almeida, J.S.; Xavier, A.M.R.B.; Carrondo, M.J.T.. "Elucidation of the mechanism of lactic acid growth inhibition and production in batch cultures of Lactobacillus rhamnosus". Applied Microbiology and Biotechnology 48 3 (1997): 346-350. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030953411&partnerID=MN8TOARS.
    10.1007/s002530051060
  141. Xavier, A.M.R.B.; Goncalves, L.M.D.; Moreira, J.L.; Carrondo, M.J.T.. "Operational patterns affecting lactic acid production in ultrafiltration cell recycle bioreactor". Biotechnology and Bioengineering 45 4 (1995): 320-327. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029239546&partnerID=MN8TOARS.
    10.1002/bit.260450406
  142. Gonçalves, L.M.D.; Barreto, M.T.O.; Xavier, A.M.B.R.; Carrondo, M.J.T.; Klein, J.. "Inert supports for lactic acid fermentation -a technological assessment". Applied Microbiology and Biotechnology 38 3 (1992): 305-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026437841&partnerID=MN8TOARS.
    10.1007/BF00170077
  143. Crespo, J.P.S.G.; Xavier, A.M.R.B.; Barreto, M.T.O.; Gonçalves, L.M.D.; Almeida, J.S.; Carrondo, M.J.T.. "Tangential flow filtration for continuous cell recycle culture of acidogenic bacteria". Chemical Engineering Science 47 1 (1992): 205-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026617133&partnerID=MN8TOARS.
  144. CRESPO, JPSG; XAVIER, AMRB; BARRETO, MTO; GONCALVES, LMD; ALMEIDA, JS; CARRONDO, MJT. "TANGENTIAL FLOW FILTRATION FOR CONTINUOUS CELL RECYCLE CULTURE OF ACIDOGENIC BACTERIA". Chemical Engineering Science 47 1 (1992): 205-214.
    10.1016/0009-2509(92)80214-W
  145. Reis, M.A.M.; Lemos, P.C.; Martins, M.J.; Costa, P.C.; Goncalves, L.M.D.; Carrondo, M.J.T.. "Influence of sulfates and operational parameters on volatile fatty acids concentration profile in acidogenic phase". Bioprocess Engineering 6 4 (1991): 145-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025963769&partnerID=MN8TOARS.
    10.1007/BF00369251
  146. Goncalves, L.M.D.; Xavier, A.M.R.B.; Almeida, J.S.; Carrondo, M.J.T.. "Concomitant substrate and product inhibition kinetics in lactic acid production". Enzyme and Microbial Technology 13 4 (1991): 314-319. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026136571&partnerID=MN8TOARS.
    10.1016/0141-0229(91)90150-9
  147. Reis, M.A.M.; Goncalves, L.M.D.; Carrondo, M.J.T.. "Sulfate reduction in acidogenic phase anaerobic digestion". Water Science and Technology 20 11-12 (1988): 345-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024217388&partnerID=MN8TOARS.
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    10.1080/09593338809384632
Thesis / Dissertation
  1. Cordeiro, Sandra Isabel Nunes. "Antioxidant – loaded mucoadhesive nanoparticles for eye drug delivery: new strategy to reduce the oxidative stress". Master, 2019. http://hdl.handle.net/10362/90121.
  2. Saraiva, Ana Sofia Domingues Santos. "Polylactic acid 3D scaffolds as platforms for local-delivery and hyperthermia applications in bone tumours". Master, 2019. http://hdl.handle.net/10362/89996.
  3. Anjos, Inês Isabel Lopes dos. "Characterization of a dual function minocycline-loaded bone scaffold". Master, 2019. http://hdl.handle.net/10362/85986.
  4. Neves, Lara Mariana Almeida Duarte Das. "Chitosan scaffolds containing calcium phosphates and diclofenac for bone regeneration – Development, validation and optimization". Master, 2018. http://hdl.handle.net/10451/40026.
  5. Pereira, Telmo Galvão. "Development of new gene delivery carriers based on lipid nanoparticles". Master, 2017. http://hdl.handle.net/10362/28739.
  6. Calado, Raquel Sofia D´Abreu. "Development of a topical mucoadhesive ocular delivery system for ceftazidime". Master, 2017. http://hdl.handle.net/10451/34259.
  7. D’Abreu, Diana Pereira. "Sistemas de nanopartículas híbridas para veiculação de DNA". Master, 2017. http://hdl.handle.net/10451/36115.
  8. Teixeira, Marina da Silva. "Development of new hybrid gene delivery carriers". Master, 2017. http://hdl.handle.net/10362/36889.
  9. Lopes, Elizabeth de Abreu. "Spirooxadiazoline oxindoles: synthesis and evaluation of anticancer and antimalarial activities". Master, 2017. http://hdl.handle.net/10362/24089.
  10. Caetano, Liliana Aranha, 1982-. "Novel particulate BCG-loaded delivery system for mucosal immunization against tuberculosis". PhD, 2016. http://hdl.handle.net/10451/24003.
  11. Silva, Mariana Monteiro da. "The use of nanoparticles as drug delivery systems for topical administration in the eye". Master, 2016. http://hdl.handle.net/10451/35880.
  12. Sadrudine, Adam. "Sistemas de nanopartículas lipídicas para veicular fármacos para a via oral". Master, 2015. http://hdl.handle.net/10451/27088.
  13. Pintado, Sara Cristina dos Santos. "Estratégias de vacinação contra a infeção por Helicobacter pylori". Master, 2015. http://hdl.handle.net/10451/27068.
  14. Costa, Beatriz Mariano Silva e. "Estado actual da vacinação contra a tuberculose". Master, 2015. http://hdl.handle.net/10451/26790.
  15. Feliz, Marina Alexandra Antunes. "An acrylic reline resin loaded with chlorhexidine : exploring the initial concept". Master, 2015. http://hdl.handle.net/10451/26978.
  16. Silva, Sofia Miguel dos Reis Pinto da. "Novel antibiotic-loaded orthopaedic bone cements: insights on drug release profiles and biocompatibility". Master, 2015. http://hdl.handle.net/10362/16211.
  17. Joaquim, Cecília de Jesus. "Nanopartículas como sistemas transportadores de fármacos para a via ocular". Master, 2014. http://hdl.handle.net/10451/36758.
  18. Amaral, Maria Rita Rebocho Lopes do. "Evaluation of a new vaccine based on pDNA and recombinant protein against Helicobacter pylori". Master, 2012. http://hdl.handle.net/10362/8520.

Other

Other output
  1. New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity. 2018. Barbara S. Gregorí Valdes; Clara S. B. Gomes; Pedro T. Gomes; José R. Ascenso; Hermínio P. Diogo; Lídia M. Gonçalves; Rui Galhano dos Santos; Helena M. Ribeiro; João C. Bordado. https://doi.org/10.20944/preprints201809.0445.v1.
    10.20944/preprints201809.0445.v1
  2. Comparative study of chitosan-and PEG-coated lipid and PLGA nanoparticles as oral delivery systems for cannabinoids. 2015. Durán-Lobato M , Martín-Banderas L, Gonçalves LMD, Fernández-Arévalo M, Almeida AJ.
    10.1007/s11051-015-2875-y
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/01/01 - 2027/12/31 Co-supervision of PhD thesis in Veterinary Sciences in the specialty of Clinical "Hybrid nanoparticulate system development for co-delivering drugs for retinal ischemic diseases"
Co-supervisor of Gonçalo Nuno Spinola Santos
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2022/12/01 - 2027/01/01 Supervision of PhD thesis in Pharmaceutical Technology "Nanoplatform for improved delivery of relevant antigens from mucosal-invading pathogens"
Supervisor
 Doutoral em Pharmaceutical Technology (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/01/01 - 2025/01/31 Co-supervision of the PhD thesis in Pharmaceutical Technology: "Nanovaccine for oral immunisation to break the link between periodontitis and Alzheimer¿s disease"
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/01/01 - 2024/12/31 Co-supervision of the PhD thesis in in Pharmaceutical Technology : "The interplay between antimicrobial drugs, nanoparticles and scaffolds in bone infection environment"
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/09/01 - 2023/09/30 Supervision of Master Thesis: "Hybrid nanoparticles to co-delivery drugs with improved properties for topical ocular application"
Supervisor of André Moreira Marques
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/05/01 - 2023/09/01 Supervision of Master "The impact of liquid lipid in the formulation for topical ocular application of lipid-polymer hybrid nanoparticles: drug loading and release profile"
Supervisor
 Master in Biopharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/01/01 - 2022/12/31 Retinal erythropoietin distribution and neuroprotective effect in a nanoparticulate drug delivery system after subconjunctival and topical administration in an animal glaucoma model
Co-supervisor
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2021/09/01 - 2022/09/30 Supervision of Master :"Topical eye drug delivery: hybrid nanoparticles into gels with improved bioactivity mucoadhesive properties"
Supervisor
 Bioquímica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/09/01 - 2022/09/30 Supervision Master theesis in Biotechnology "Development of hybrid lipid nanoparticles for gene delivery"
Supervisor
 Biotecnologia (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/06/01 - 2020/09/01 Supervision of Master degree of Raneem Jnaidi “Lipid based nanoparticles for Glioblastoma treatment”. Master in Biopharmaceutical Sciences from FFUL
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09/01 - 2019/09/01 Supervision of Master degree of Ana Sofia Saraiva “3D scaffolds for delivery of metal nanoparticles for application in bone tumours”. Master in Molecular Genetics and Biomedicine from Faculdade Ciências e Tecnologia da Universidade Nova de Lisboa (FCT/UNL).
Supervisor
 Bioquímica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/09/01 - 2017/09/01 Supervision of Master degree of Telmo Pereira “Development of new gene delivery carriers based on lipid nanoparticles”. Mestrado em Bioquimica from Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa (FCT/UNL).
Supervisor
 Bioquimica (Master)
Universidade Nova de Lisboa Departamento de Ciências e Tecnologia da Biomassa, Portugal
2016/09/01 - 2017/09/01 Supervision of Master degree of Marina Teixeira “Development of new gene hybrid delivery carriers”. Mestrado em Bioquimica from Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa (FCT/UNL).
Supervisor
 Bioquímica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2017 Development of a topical mucoadhesive ocular delivery system for ceftazidime
Supervisor
 Ciências Biofarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017 Supervision of Master degree of Raquel Calado “Developmento of a topical mucoadhesie ocular delivery system for ceftadizime”. Master in Biopharmaceutical Sciences from FFUL
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2013 Novel particulate BCG-loaded delivery system for mucosal immunization against tuberculosis
Supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/09/01 - 2012/09/01 Supervision of Master degree of Maria Rita Rebocho Lopes do Amaral entitle “Evaluation of a new vaccine based on pDNA and recombinant protein against Helicobacter pylori” to be presented at Faculty of Scicences and Technology of New University of Lisbon.
Supervisor
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Distinctions

Award

2023 "Prémio Professor Miguel Faria”.
2022 "Prémio de melhor artigo de aluno de doutoramento do CIISA -2020"
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2021 Best Oral Presentation at Annual ESVO Meeting 2021 “Silva B et al., In vivo evaluation of a nanoparticulate system for EPOß ocular delivery by subconjunctival route”.
European Society of Veterinary Ophthalmology, Spain
2020 Best Paper Awards 2019
2020 Prémio melhor comunicação oral
Sociedade Portuguesa de Doenças Metabólicas, Portugal

Other distinction

2017 Prize BINOV2016, Portuguese Pharmaceutics Association.
2016 Prize Academia-Industry Partnership for Collaborative Studies, from iMed.UL
2016 Best Poster Presentation
2015 Best Poster Presentation
2014 Best Poster Presentation