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Pedro Henrique Magalhães Fernandes Pais. Publicou 19 artigos em revistas especializadas. Atua na(s) área(s) de Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Microbiologia.
Identification

Personal identification

Full name
Pedro Henrique Magalhães Fernandes Pais

Citation names

  • Pais, Pedro

Author identifiers

Ciência ID
7212-18FA-8EDA
ORCID iD
0000-0001-5628-416X

Email addresses

  • pedrohpais@tecnico.ulisboa.pt (Professional)

Telephones

Mobile phone
  • 912682366 (Personal)

Addresses

  • Av. Rovisco Pais, 1049-001, Lisboa, Lisboa, Portugal (Professional)
  • Rua Aura Abranches, nº8, 4º esquerdo, 1500-067, Benfica, Lisboa, Portugal (Personal)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
German Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2015/09 - 2019/09
Concluded
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Unveiling the complex regulatory network governing antifungal drug resistance in Candida glabrata: from new regulators to new effectors" (THESIS/DISSERTATION)
2012/09 - 2014/07
Concluded
 Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"The membrane proteome-wide response to the antifungal drug clotrimazole in Candida glabrata: role of the transcription factor CgPdr1 and the drug:H+ antiporters CgTpo1_1 and CgTpo1_2" (THESIS/DISSERTATION)
 18
2009/09 - 2012/07
Concluded
 Biologia Celular e Molecular (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2020/01 - Current Postdoc (Research) Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/09 - 2019/12 Contracted Researcher (Research) Universidade de Lisboa Instituto Superior Técnico, Portugal
Projects

Grant

Designation Funders
2019/09 - 2019/12 BIODATA - Portuguese Infrastructure of Biological Data
o LISBOA-01-0145-FEDER-022231
Research Fellow
Ongoing

Contract

Designation Funders
2020/01 - Current MIXED-UP – Targeting pathogenesis and engineering cell factories: by developing mixed regulatory-metabolic genomic models in yeasts
PTDC/BII-BIO/28216/2017
Post-doc Fellow
Ongoing
2015/09 - 2019/10 CANTROL - Deciphering the mechanisms of transcriptional regulation that control antifungal drug resistance in the pathogenic yeast Candida glabrata: aiming the development of improved diagnosis and therapeutic approaches
PTDC/BBB-BIO/4004/2014
PhD Student Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
Concluded
2013/09 - 2014/04 FUNDRING - Identification of new biomarkers of antiFUNgal Drug Resistance diagnosis IN Candida Glabrata: the particular role of multidrug resistance transporters
PTDC/EBB-BIO/119356/2010
Other
Universidade de Lisboa Instituto Superior Técnico, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Cavalheiro M; Costa C; Pais, Pedro; Teixeira MC. "Acquisition of resistance to azole antifungal drugs in Candida species: imidazoles versus triazoles". In Advances in Medicine and Biology. Nova Science Publishers, 2016.
    Published
  2. Costa C; Pais, Pedro; Teixeira MC. "Multidrug resistance in pathogenic yeasts: emphasis on the role of ABC and MFS multidrug transporters". In The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs, 947-954. Formatex, 2015.
Conference poster
  1. Galocha M; Silva-Dias A; Pais, Pedro; Cavalheiro M; Miranda IM; Chibana H; Rodrigues AG; Teixeira MC. "C. glabrata evolution towards posaconazole resistance irrespective of PDR1 GOF mutations". Paper presented in HFP2019 – Advanced Lecture Course in Molecular Mechanisms of Host-Pathogen Interactions and Virulence in Human Fungal Pathogens, 2019.
  2. Pais, Pedro; Galocha M; Califórnia R; Chibana H; Sá-Correia I; Monteiro PT; Butler G; Teixeira MC. "Fighting human candidiasis: the use of systems biology approaches". Paper presented in Encontro Ciência ‘18, 2018.
  3. Pais, Pedro; Galocha M; Monteiro PT; Teixeira MC. "PathoYeastract: a free web information system designed to fully exploit transcription regulation data in pathogenic yeasts". Paper presented in Annual Meeting of the Portuguese Society of Genetics, 2018.
  4. Pais, Pedro; Galocha M; Monteiro PT; Teixeira MC. "The PathoYeastract database: a tool for the study of transcription regulation in Candida species". Paper presented in 14th ASM Conference on Candida and Candidiasis, 2018.
  5. Cavalheiro M; Rui Santos; Romão D; Mil-Homens D; Pais, Pedro; Costa C; Viana R; et al. "Determining virulence by protecting the cell from host induced stresses: the unexpected role of C. glabrata multidrug transporters". Paper presented in MICROBIOTEC’17, 2017.
  6. Pais, Pedro; Galocha M; Cavalheiro M; Costa C; Califórnia R; Leitão C; Diana Pereira; Butler G; Teixeira MC. "Deciphering transcription regulation of antifungal drug resistance in the pathogenic yeast Candida glabrata". Paper presented in MICROBIOTEC’17, 2017.
  7. Pais, Pedro; Costa C; Pires C; Cavalheiro M; Teixeira MC. "Using pathoproteomics to unveil new players in antifungal drug resistance in the human pathogenic yeast Candida glabrata". 2017.
  8. Cavalheiro M; Rui Santos; Romão D; Mil-Homens D; Pais P; Costa C; Galocha M; Fialho AM; Teixeira MC. "A new role for C. glabrata drug:H+ antiporters: in the crossroad between drug resistance and virulence". 2017.
  9. Romão D; Rui Santos; Mil-Homens D; Costa C; Pais P; Fialho AM; Teixeira MC. "Role of uncharacterized drug:H+ antiporters in C. glabrata pathogenicity". 2016.
  10. Pais, Pedro; Costa C; Pires C; Romão D; Cavalheiro M; Teixeira MC. "Role of uncharacterized drug:H+ antiporters in C. glabrata pathogenicity". Paper presented in PYFF6 - 6th Conference on Physiology of Yeasts and Filamentous Fungi, 2016.
  11. Pais, Pedro; Costa C; Pires C; Rui Santos; Cavalheiro M; Teixeira MC. "New mechanisms of 5-flucytosine resistance in the human pathogen Candida glabrata: unveiled through chemogenomics and proteomics approaches". Paper presented in MICROBIOTEC'15, 2015.
  12. Pais, Pedro; Pires C; Costa C; Teixeira MC. "Membrane proteome-wide response to the antifungal drug clotrimazole in Candida glabrata: role of the transcription factor CgPdr1 and the drug:H+ antiporters CgTpo1_1 and CgTpo1_2". Paper presented in Jornadas de Biologia de Leveduras Professor Nicolau Van Uden, 2014.
Journal article
  1. Mafalda Cavalheiro; Daniela Romão; Rui Santos; Dalila Mil-Homens; Pedro Pais; Catarina Costa; Mónica Galocha; et al. "Role of CgTpo4 in Polyamine and Antimicrobial Peptide Resistance: Determining Virulence in Candida glabrata". International Journal of Molecular Sciences 22 3 (2021): 1376-1376. https://doi.org/10.3390/ijms22031376.
    10.3390/ijms22031376
  2. Pais, Pedro. "Transcriptome-wide differences between Saccharomyces cerevisiae and Saccharomyces cerevisiae var. boulardii: Clues on host survival and probiotic activity based on promoter sequence variability". Genomics 113 2 (2021): 530-539. https://www.sciencedirect.com/science/article/pii/S0888754321000288?via%3Dihub.
    Published
  3. Pedro Pais; Vanda Almeida; Melike Yilmaz; Miguel C. Teixeira. "Saccharomyces boulardii: What Makes It Tick as Successful Probiotic?". Journal of Fungi (2020): https://doi.org/10.3390/jof6020078.
    10.3390/jof6020078
  4. Pais, Pedro. "A new regulator in the crossroads of oxidative stress resistance and virulence in Candida glabrata: The transcription factor CgTog1". Virulence 11 1 (2020): 1522-1538. http://dx.doi.org/10.1080/21505594.2020.1839231.
    10.1080/21505594.2020.1839231
  5. Monteiro PT; Oliveira J; Pais P; Antunes M; Palma M; Cavalheiro M; Galocha M; et al. "YEASTRACT+: a portal for cross-species comparative genomics of transcription regulation in yeasts.". Nucleic acids research (2019): http://europepmc.org/abstract/med/31586406.
    10.1093/nar/gkz859
  6. Pais P; Galocha M; Miranda IM; Rodrigues AG; Teixeira MC. "Draft Genome Sequences of Three Clinical Isolates of the Pathogenic Yeast Candida glabrata.". Microbiology resource announcements (2019): http://europepmc.org/abstract/med/31467089.
    10.1128/MRA.00278-19
  7. Mónica Galocha; Pedro Pais; Mafalda Cavalheiro; Diana Pereira; Romeu Viana; Miguel C. Teixeira. "Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin". International Journal of Molecular Sciences (2019): https://www.mdpi.com/1422-0067/20/9/2345.
    10.3390/ijms20092345
  8. Pais P; Galocha M; Viana R; Cavalheiro M; Pereira D; Teixeira MC. "Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection.". Microbial cell (Graz, Austria) (2019): http://europepmc.org/abstract/med/30854392.
    10.15698/mic2019.03.670
  9. Pais P; Galocha M; Teixeira MC. "Genome-Wide Response to Drugs and Stress in the Pathogenic Yeast Candida glabrata.". Progress in molecular and subcellular biology (2019): http://europepmc.org/abstract/med/30911893.
    10.1007/978-3-030-13035-0_7
  10. Cavalheiro M; Costa C; Silva-Dias A; Miranda IM; Wang C; Pais P; Pinto SN; et al. "A Transcriptomics Approach To Unveiling the Mechanisms of In Vitro Evolution towards Fluconazole Resistance of a Candida glabrata Clinical Isolate.". Antimicrobial agents and chemotherapy (2018): http://europepmc.org/abstract/med/30348666.
    10.1128/AAC.00995-18
  11. Cavalheiro M; Pais P; Galocha M; Teixeira MC. "Host-Pathogen Interactions Mediated by MDR Transporters in Fungi: As Pleiotropic as it Gets!". Genes (2018): http://europepmc.org/abstract/med/30004464.
    10.3390/genes9070332
  12. Romão D; Cavalheiro M; Mil-Homens D; Santos R; Pais P; Costa C; Takahashi-Nakaguchi A; et al. "A New Determinant of Candida glabrata Virulence: The Acetate Exporter CgDtr1.". Frontiers in cellular and infection microbiology (2017): http://europepmc.org/abstract/med/29184852.
    10.3389/fcimb.2017.00473
  13. Pais, Pedro. "YEASTRACT: an upgraded database for the analysis of transcription regulatory networks in Saccharomyces cerevisiae.". Nucleic acids research (2017): http://europepmc.org/abstract/med/29036684.
    10.1093/nar/gkx842
  14. Santos R; Costa C; Mil-Homens D; Romão D; de Carvalho CC; Pais P; Mira NP; Fialho AM; Teixeira MC. "The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata.". (2017): http://europepmc.org/abstract/med/27780306.
    10.1111/cmi.12686
  15. Monteiro PT; Pais P; Costa C; Manna S; Sá-Correia I; Teixeira MC. "The PathoYeastract database: an information system for the analysis of gene and genomic transcription regulation in pathogenic yeasts.". (2017): http://europepmc.org/abstract/med/27625390.
    10.1093/nar/gkw817
  16. Pais P; Costa C; Pires C; Shimizu K; Chibana H; Teixeira MC. "Membrane Proteome-Wide Response to the Antifungal Drug Clotrimazole in Candida glabrata: Role of the Transcription Factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2.". (2016): http://europepmc.org/abstract/med/26512119.
    10.1074/mcp.m114.045344
  17. Pais P; Costa C; Cavalheiro M; Romão D; Teixeira MC. "Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison.". (2016): http://europepmc.org/abstract/med/27812511.
  18. Pais P; Pires C; Costa C; Okamoto M; Chibana H; Teixeira MC. "Membrane Proteomics Analysis of the Candida glabrata Response to 5-Flucytosine: Unveiling the Role and Regulation of the Drug Efflux Transporters CgFlr1 and CgFlr2.". (2016): http://europepmc.org/abstract/med/28066366.
    10.3389/fmicb.2016.02045
  19. Costa C; Ponte A; Pais P; Santos R; Cavalheiro M; Yaguchi T; Chibana H; Teixeira MC. "New Mechanisms of Flucytosine Resistance in C. glabrata Unveiled by a Chemogenomics Analysis in S. cerevisiae.". (2015): http://europepmc.org/abstract/med/26267134.
    10.1371/journal.pone.0135110
Online resource
  1. Pais, Pedro. Yeastract+ portal. 2019. http://www.yeastract.com/.
  2. Pais, Pedro. PathoYeastract database. 2017. http://pathoyeastract.org/.
  3. Pais, Pedro. Yeastract database. 2011. http://www.yeastract.com/.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/12 Tackling azole antifungal resistance in Candida glabrata: in the crossroad between three complex regulatory pathways Microbiotec’19
(Coimbra, Portugal)
2019/09 New clues on the probiotic activity of Saccharomyces boulardii, obtained from global gene promoter analysis Neuroscience, Bioinformatics, Microbiome and Beyond International Conference
(Bachinovo, Bulgaria)
2019/04 Candida glabrata transcription factor Rpn4 regulates fluconazole resistance by transcriptional control of ergosterol biosynthesis and plasma membrane stability 29th ECCMID
(Amsterdam, Netherlands)
2019 YEASTRACT+: a comparative genomics platform for the analysis of transcriptional regulatory networks in yeast species Bioinformatic Open Days'19
(Braga, Portugal)
2018/06 Beyond MDR transporter-mediated azole resistance in Candida glabrata: functional characterization of the transcription factors CgRpn4 and CgMrr1 XXI Jornadas de Biologia de Leveduras
(Braga, Portugal)
2018/04 Functional characterization of the transcription factor CgMrr1 suggests new players governing azole drug resistance in Candida glabrata 14th ASM Conference on Candida and Candidiasis
(Providence, RI, United States)
2017/05 Unveilling transcriptional regulation in Candida species: using the PathoYeastract HFP2017 – Advanced Lecture Course in Molecular Mechanisms of Host-Pathogen Interactions and Virulence in Human Fungal Pathogens
(Nice, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/09 - Current Implementation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 in Candida glabrata
Co-supervisor
 Biotecnologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016/07 - Current Helper to the Organizing Committee of PYFF6 – 6th Conference on Physiology of Yeast and Filamentous Fungi (2016/07)
Conference (Member of the Organising Committee)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/07 - Current Helper to the Organizing Committee of the XX Jornadas de Biologia de Leveduras Professor Nicolau Van Uden (2014/07)
Conference (Member of the Organising Committee)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/09 - 2019/09 Cooperation in the organization of the International Microorganism Day 2019 (2019/09)
Other (Member of the Organising Committee)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/09 - 2018/09 Cooperation in the organization of the International Microorganism Day 2018 (2019/09)
Other (Member of the Organising Committee)
 Universidade de Lisboa Instituto Superior Técnico, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2017/10 - Current Genome Assembly and Annotation course from the Elixir platform
Workshop
 Genome Assembly and Annotation course from the Elixir platform
Instituto Gulbenkian de Ciência, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/11 Mechanisms of echinocandin resistance in Candida spp.
(Thesis) Main arguer
 Morgana Inês Vieira de Oliveira e Castro (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2016/04 - 2026/05 Experimental laboratory classes of Molecular Biology and Biochemistry to undergraduate students from the Biological Engineering, Chemical Engineering, and Materials Engineering degrees (Licenciatura) Universidade de Lisboa Instituto Superior Técnico, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2020/11 - 2020/11 Microorganisms (2076-2607) MDPI AG
2020/09 - 2020/09 Microorganisms (2076-2607) MDPI AG
2020/07 - 2020/07 Genes (2073-4425) MDPI AG
2020/07 - 2020/07 Journal of Fungi (2309-608X) MDPI AG
2020/06 - 2020/06 Antibiotics (2079-6382) MDPI AG
2020/05 - 2020/05 Antibiotics (2079-6382) MDPI AG
2020/04 - 2020/04 International Journal of Molecular Sciences (1422-0067) MDPI AG
2020/02 - 2020/03 Scientific Reports (2045-2322) Springer Science and Business Media LLC

Other jury / evaluation

Activity description Institution / Organization
2017/05 - Current Member of the poster judging committee at HFP2017
Distinctions

Award

2015 2nd place of best poster presentation at Microbiotec’ 15

Other distinction

2019 Microbiotec’19 FEMS Early Career Researcher Grant
2019 29th ECCMID Travel Grant
2017 HFP2017 Young Scientist’s Meeting Grant
2016 PYFF6 Young Scientist Meeting Grant