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Jorge Lima is Head of R&D and Vice-Director at Ipatimup. He is also Associate Researcher at Ipatimup-i3S and Affiliated Professor at FMUP. Jorge's research focuses on understanding the oncogenic properties and inherent biomarkers of adult and paediatric brain tumours. He is also interested in the crosstalk between altered metabolism and the oncogenic properties of cancer cells. His work has provided important insights for the role played by metabolic enzymes in inherited neoplasias and the effects of mitochondrial deficiency in cancer cells. Jorge studies brain tumours and he contributed to understand the role played by IDH and TERTp mutations, identify biomarkers of therapy resistance, test novel delivery methods and investigate the metabolic features of stem-like cells. He is also particularly dedicated to paediatric brain tumours and in translating their genomic features to the clinical practice, by creating a fruitful collaboration between Ipatimup and the departments of paediatric oncology of 4 reference clinical centres in Portugal - CHUSJ, IPO-Lisboa, IPO-Porto and Hospital Pediatrico de Coimbra. Besides research, Jorge is also Molecular Diagnostics Consultant for adult and paediatric brain tumours at Ipatimup. Jorge is currently PI of 4 projects, 3 of them specifically dedicated to CNST. He has supervised 5 Msc and 3 PhD students to completion, and he is involved in several teaching activities. He has been leading collaborations between i3S/Ipatimup and international institutes, such as Roswell Park Cancer Institute, Weill Cornell Medical College, Wurzburg University and Heidelberg University. Jorge is a member of the board in ASPIC (Portuguese Association for Cancer Research), coordinator of the Paediatric Cancer Working Group in the National Cancer Hub (Portugal) and integrates the Paediatric Oncology Tumour Board at CHUSJ and IPO-Lisboa. He has co-authored >50 peer-reviewed publications, with >3000 citations and a H-index of 23.
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Identification

Personal identification

Full name
Jorge Filipe de Almeida Vieira Lima

Citation names

  • Lima, Jorge
  • Lima, J

Author identifiers

Ciência ID
7213-D09A-5631
ORCID iD
0000-0001-7780-0901
Researcher Id
J-5975-2013
Scopus Author Id
35475530400

Telephones

Telephone
  • 225570700 (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Medical and Health Sciences - Basic Medicine - Pathology
  • Medical and Health Sciences - Clinical Medicine - Paediatrics
  • Medical and Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2009
Concluded
 Mitochondrial deficiency in cancer cells (Pós-doutoramento)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Roswell Park Comprehensive Cancer Center Department of Cancer Genetics, United States
2006
Concluded
 Human Biology (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"Succinate Dehydrogenase in Human Tumours: Mutational Analysis of SDHB, SDHC and SDHD in Paragangliomas, Phaeochromocytomas and Medullary Thyroid Carcinomas" (THESIS/DISSERTATION)
 Approved by unanimity
2000
Concluded
 Biology - Scientific branch (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Identification and typing of bacteria of the genre Legionella" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2015/10/01 - Current Principal Investigator (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/07/01 - 2022/07/07 Research Assistant (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2009/07/01 - 2015/06/30 Contracted Researcher (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2000/10/01 - 2002/09/30 Researcher (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2015 - Current Lecturer (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal

Positions / Appointments

Category
Host institution 		Employer
2022/07/01 - Current Vice-President Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2022/07 - Current Organic Unit Director Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2020/03/10 - 2024/03 Member of the board Associação Portuguesa de Investigação em Cancro, Portugal

Others

Category
Host institution 		Employer
2007/01/01 - 2009/07/31 Post-Doc Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2002/10/01 - 2006/09/30 PhD Fellow Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projects

Grant

Designation Funders
2023/11/01 - 2025/11/01 POPCARE: Pediatric Oncology Precision Care Platform
NA
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Bayer HealthCare AG
Ongoing
2022/09/01 - 2024/08/31 Abordagem multi-ómica em organoides ex-vivo 3D para medicina de precisão em tumores pediátricos do sistema nervoso central – OMICS.ORG
OMICS.ORG
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Liga Portuguesa Contra o Cancro
Ongoing

Contract

Designation Funders
2022/02 - Current Ex-vivo 3D organoids for precision medicine in pediatric brain tumors - EX-BRAIN.ORG
Fundaca Rui Osório de Castro
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/01 - Current PRECISEKIDS - Molecular Biomarkers for Precision Medicine in Paediatric Patients With Solid Tumours
na
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Ongoing
2020/09 - Current Bioengineered nanocarriers for targeted drug delivery in glioblastoma multiforme therapy
Maratona da Saude
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing
2020/07/01 - Current Implementation of molecular biomarkers in liquid biopsy for precision medicine in paediatric brain tumour patients – PEDILIQ
NA
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing
2019/01/01 - Current MGMT methylation in Glioblastomas
NA
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Ongoing
2022/07/01 - 2025/06/30 Engineered nano-based device for glioblastoma multiforme therapy
M-ERA-NET3/0002/2021
10.54499/M-ERA-NET3/0002/2021
Project9034
Co-Principal Investigator (Co-PI)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia

European Commission
Ongoing
2023/03/01 - 2024/08/31 Unravel familial non-medullary thyroid cancer aetiology: A Genetic Orphan Disease.
2022.05763.PTDC
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/10/01 - 2021/10/01 Setting up molecular biomarkers for precision medicine in paediatric brain tumour patients
NA
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Liga Portuguesa Contra o Cancro Núcleo Regional do Norte
Concluded
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
10.54499/LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/03/01 - 2015/08/31 Mapping of genes predisposing to familial thyroid tumours
PIC/IC/83037/2007
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/07/01 - 2014/06/30 Untitled
CONT_DOUT/33/IPATIMUP/224/10338/ 13/2008
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 3 - 2011-2012
PEst-C/SAU/LA0003/2011
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012/06/30 Cancer risk and irradiation: an epidemiological and genetic study of a cohort irradiated for Tinea capitis
PIC/IC/83154/2007
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/01/01 - 2009/06/30 MITOCHONDRIA AND TUMOURIGENESIS: INTEGRATING REACTIVE OXYGEN SPECIES, PROLYL HYDROXYLASES AND HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
SFRH/BPD/29197/2006
 Fundação para a Ciência e a Tecnologia
Concluded
2002/10/01 - 2006/09/30 MITOCHONDRIAL DNA ALTERATIONS IN RADIATION-INDUCED POST-CHERNOBYL THYROID TUMOURS, NORMAL THYROID PARENCHYMA AND PERIPHERAL BLOOD OF THE PATIENTS
SFRH/BD/8425/2002
 Fundação para a Ciência e a Tecnologia
Concluded
2005/09/01 - 2006/08/31 Inactivation of mitochondrial complex II tumor suppressor genes in sporadic and familiar paragangliomas and pheochromocytomas
POCI/SAU-OBS/61945/2004
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2023/12 - Current Pediatric Differentiated Thyroid Carcinoma Registry – Ped-DTC
NA
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Ongoing
2022/01/01 - Current The European Osteosarcoma Consortium FOSTER (Fight Osteosarcoma Through European Research)
na
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Ongoing
2019/09/01 - Current AN INTERNATIONAL PROSPECTIVE TRIAL ON MEDULLOBLASTOMA (MB) IN CHILDREN OLDER THAN 3 TO 5 YEARS WITH WNT BIOLOGICAL PROFILE (PNET 5 MB – LR and PNET 5 MB – WNT-HR), AVERAGE-RISK BIOLOGICAL PROFILE (PNET 5 MB -SR), OR TP53 MUTATION, AND REGISTRY FOR MB OCURRING IN THE CONTEXT OF GENETIC PREDISPOSITION
SIOP PNET 5 Medulloblastoma
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Ongoing
2019/06/05 - Current AN INTERNATIONAL PROSPECTIVE TRIAL ON HIGH-RISK MEDULLOBLASTOMA IN PATIENTS OLDER THAN 3 YEARS
SIOP High-Risk Medulloblastoma
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Ongoing
Outputs

Publications

Book
  1. Lima, J.; Máximo, V.; Soares, P.; Portugal, R.; Guimarães, S.; Sobrinho-Simões, M.. Mitochondria and oncocytomas. 2009.
    10.1007/978-0-387-84835-8_11
Book chapter
  1. Ferreira, Bárbara; Peixoto, Joana; Lima, Jorge; Bárbara Ferreira; Joana Peixoto; Jorge Lima. "Application and Relevance of Organoid/Tumoroid Models in the Context of Pediatric Solid Tumors". In Reference Module in Biomedical Sciences. Elsevier, 2023.
    10.1016/b978-0-443-15717-2.00011-1
Conference abstract
  1. Lima, J; Pinheiro, J; Nunes, S; Fernandes, AP; Soares, P; Machado, JC; Pereira, J; da Costa, MJG. "NGS MOLECULAR PROFILE OF PAEDIATRIC BRAIN TUMOURS: RESULTS FROM 92 CONSECUTIVE PATIENTS TREATED AT CENTRO HOSPITALAR UNIVERSITARIO DE SAO JOAO". 2022.
  2. "Insights into the regulation of GRIM-19 expression in renal cell carcinoma". Paper presented in 17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity, Amsterdam, 2013.
    Published
  3. "Using an in Vitro Model of EpithelialMesenchymal-Epithelial Transitions to Uncover Novel Biological Mechanisms". 2012.
  4. "A novel germline SDHB mutation in a GIST patient without associated paraganglioma or pheochromocytoma.". 2011.
    Published
  5. "Associations between functional EGFR polymorphisms and glioma risk". Paper presented in 21st Meeting of the European Association for Cancer Research, oslo, 2010.
    Published
  6. "Mitochondrial DNA mutations in Ukrainian and Russian post-Chernobyl thyroid tumours". Paper presented in 6th edition of EUROMIT, Nijmegen, 2004.
    Published
Conference poster
  1. Oliveira, Patricia; Carvalho, Joana; Rocha, Sara; Azevedo, Mafalda; Vieira, Andre F.; Ferreira, Daniel; Mendes, Nuno; et al. "Abstract 1611: Epithelial-mesenchymal-epithelial transition induced by long term exposure to TGFB1 creates cellular heterogeneity". Paper presented in AACR 107th Annual Meeting 2016, New Orleans, United States, 2016.
    10.1158/1538-7445.am2016-1611
  2. Melo, Miguel; Gaspar da Rocha, Adriana; Vinagre, João; Batista, Rui; Peixoto, Joana; Celestino, Ricardo; Salgado, Catarina; et al. "Prognostic significance of TERT promoter mutations in follicular cell-derived thyroid carcinomas". Paper presented in 16th European Congress of Endocrinology, Wroclaw, Poland, 2014.
    10.1530/endoabs.35.P1149
  3. Lima, Jorge; Reis, Rui Manuel; Catarino, Telmo; Peixoto, Joana; Vinagre, João; Batista, Rui; Castro, Ligia; et al. "Abstract C118: TERT promoter mutations in human gliomas.". Paper presented in AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, 2013.
  4. Oliveira, Patrícia Joana Morais Ferreira; Seruca, Raquel; Ferreira, Daniel; Azevedo, Mafalda; Vinagre, João; Mendes, Nuno; Carneiro, Fátima; et al. "An in vitro model for Epithelial-Mesenchymal-Epithelial transitions as a novel tool to study cancer progression". Paper presented in I3S Scientific Retreat, 2012.
  5. Vinagre, João; Bento, Inês; Ferreira-da-Silva, André; Lima, Jorge; Soares, Paula; Máximo, Valdemar. "The role of GRIM-19 in thyroid tumours". Paper presented in Modulation of programmed cell death and therapeutic targets in cancer and neurodegenerative diseases, Porto, Portugal, 2009.
  6. Figueiredo, Tália; Lima, Jorge; Sobrinho-Simões, Manuel. "High frequency of germline SDHB and SDHD mutations in apparently sporadic head and neck paragangliomas from Spain.". Paper presented in 7th Congress of the European Skull Base SocietyFulba, 2005.
Journal article
  1. Maria João Ramalho; Serra, Érica; Lima, Jorge; Loureiro, Joana Angélica; Pereira, Maria Carmo. Corresponding author: Maria João Ramalho. "Chitosan-PLGA mucoadhesive nanoparticles for gemcitabine repurposing for glioblastoma therapy". European Journal of Pharmaceutics and Biopharmaceutics 200 (2024): 114326. http://dx.doi.org/10.1016/j.ejpb.2024.114326.
    Published • 10.1016/j.ejpb.2024.114326
  2. Maria João Ramalho; Bruna Alves; Stéphanie Andrade; Jorge Lima; Joana A. Loureiro; Maria do Carmo Pereira. "Folic-Acid-Conjugated Poly (Lactic-Co-Glycolic Acid) Nanoparticles Loaded with Gallic Acid Induce Glioblastoma Cell Death by Reactive-Oxygen-Species-Induced Stress". Polymers (2024): https://www.mdpi.com/2073-4360/16/15/2161.
    10.3390/polym16152161
  3. João Paulo Brás; Tito Teles Jesus; Hugo Prazeres; Jorge Lima; Paula Soares; João Vinagre. "TERTmonitor—qPCR Detection of TERTp Mutations in Glioma". Genes (2023): https://doi.org/10.3390/genes14091693.
    10.3390/genes14091693
  4. Ramalho, Maria João; Torres, Inês David; Loureiro, Joana Angélica; Lima, Jorge; Pereira, Maria Carmo. "Transferrin-Conjugated PLGA Nanoparticles for Co-Delivery of Temozolomide and Bortezomib to Glioblastoma Cells". ACS Applied Nano Materials 6 15 (2023): 14191-14203. http://dx.doi.org/10.1021/acsanm.3c02122.
    10.1021/acsanm.3c02122
  5. Bárbara Couto Viana Alves; Joana Peixoto; Sofia Macedo; Jorge Pinheiro; Bruno Fernandes de Carvalho; Paula Soares; Jorge Lima; Raquel T. Lima. "High VEGFA Expression Is Associated with Improved Progression-Free Survival after Bevacizumab Treatment in Recurrent Glioblastoma". Cancers (2023): https://www.mdpi.com/2072-6694/15/8/2196.
    10.3390/cancers15082196
  6. Pinto, A.T.; Machado, A.B.; Osório, H.; Pinto, M.L.; Vitorino, R.; Justino, G.; Santa, C.; et al. "Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression". Cancers 15 1 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85145996698&partnerID=MN8TOARS.
    10.3390/cancers15010270
  7. Macedo-Pereira, A.; Martins, C.; Lima, J.; Sarmento, B.. "Digging the intercellular crosstalk via extracellular vesicles: May exosomes be the drug delivery solution for target glioblastoma?". Journal of Controlled Release 358 (2023): 98-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-85153896114&partnerID=MN8TOARS.
    10.1016/j.jconrel.2023.04.038
  8. Pereira-Nunes, J.; Madureira, M.; Dinis, A.; Barroca, H.; Lima, J.; do Bom-Sucesso, M.. "Kaposiform Lymphangiomatosis in a Male Adolescent: A Clinical Challenge and the Role of Genetics". Journal of Investigative Medicine High Impact Case Reports 11 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85157996696&partnerID=MN8TOARS.
    10.1177/23247096231166678
  9. Rui Bergantim; Sara Peixoto da Silva; Bárbara Polónia; Mélanie Barbosa; André Albergaria; Jorge Lima; Hugo R. Caires; José E. Guimarães; M. Helena Vasconcelos. "Detection of Measurable Residual Disease Biomarkers in Extracellular Vesicles from Liquid Biopsies of Multiple Myeloma Patients—A Proof of Concept". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/22/13686.
    10.3390/ijms232213686
  10. Ramalho, Maria João; Bravo, Maria; Loureiro, Joana Angélica; Lima, Jorge; Pereira, Maria Carmo. "Transferrin-modified nanoparticles for targeted delivery of Asiatic acid to glioblastoma cells". Life Sciences 296 (2022): 120435. http://dx.doi.org/10.1016/j.lfs.2022.120435.
    Published • 10.1016/j.lfs.2022.120435
  11. Araujo, P.B.; Carvallo, M.S.; Vidal, A.P.; Nascimento, J.B.; Wo, J.M.; Naliato, E.O.; Cunha Neto, S.H.; et al. "Case Report: Composite pheochromocytoma with ganglioneuroma component: A report of three cases". Frontiers in Endocrinology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85138972346&partnerID=MN8TOARS.
    10.3389/fendo.2022.903085
  12. Bastos, A.G.P.; Carvalho, B.; Silva, R.; Leitão, D.; Linhares, P.; Vaz, R.; Lima, J.. "Endoglin (CD105) and proliferation index in recurrent glioblastoma treated with anti-angiogenic therapy". Frontiers in Oncology 12 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85138389919&partnerID=MN8TOARS.
    10.3389/fonc.2022.910196
  13. Santos, M.; Ferreira, M.; Oliveira, P.; Mendes, N.; André, A.; Vieira, A.F.; Nunes, J.B.; et al. "Epithelial-Mesenchymal Plasticity Induced by Discontinuous Exposure to TGFß1 Promotes Tumour Growth". Biology 11 7 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85136417323&partnerID=MN8TOARS.
    10.3390/biology11071046
  14. Joana Peixoto; Sudha Janaki-Raman; Lisa Schlicker; Werner Schmitz; Susanne Walz; Alina M. Winkelkotte; Christel Herold-Mende; et al. "Integrated Metabolomics and Transcriptomics Analysis of Monolayer and Neurospheres from Established Glioblastoma Cell Lines". Cancers 13 6 (2021): 1327-1327. https://doi.org/10.3390/cancers13061327.
    10.3390/cancers13061327
  15. Lima, Jorge. "The role of c-Met and VEGFR2 in glioblastoma resistance to bevacizumab". Scientific Reports (2021):
    Accepted • 10.1038/s41598-021-85385-1
  16. Duarte, D.B.; Ferreira, L.; Santos, A.P.; Costa, C.; Lima, J.; Santos, C.; Afonso, M.; et al. "Case Report: Pheochromocytoma and Synchronous Neuroblastoma in a Family With Hereditary Pheochromocytoma Associated With a MAX Deleterious Variant". Frontiers in Endocrinology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85103508527&partnerID=MN8TOARS.
    10.3389/fendo.2021.609263
  17. Rodrigues, J.G.; Duarte, H.O.; Gomes, C.; Balmaña, M.; Martins, Á.M.; Hensbergen, P.J.; de Ru, A.H.; et al. "Terminal a2,6-sialylation of epidermal growth factor receptor modulates antibody therapy response of colorectal cancer cells". Cellular Oncology (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85104515471&partnerID=MN8TOARS.
    10.1007/s13402-021-00606-z
  18. Miranda, S.; Correia, M.; Dias, A.G.; Pestana, A.; Soares, P.; Nunes, J.; Lima, J.; Máximo, V.; Boaventura, P.. "Evaluation of the role of mitochondria in the non-targeted effects of ionizing radiation using cybrid cellular models". Scientific Reports 10 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85083166768&partnerID=MN8TOARS.
    10.1038/s41598-020-63011-w
  19. Valente Aguiar, P.; Pinheiro, J.; Lima, J.; Vaz, R.; Linhares, P.. "Myxoid mesenchymal intraventricular brain tumour with EWSR1–CREB1 gene fusion in an adult woman". Virchows Archiv (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85087554504&partnerID=MN8TOARS.
    10.1007/s00428-020-02885-7
  20. Saavedra, A.; Lima, J.; Castro, L.; Silva, R.; Macedo, S.; Rodrigues, E.; Carvalho, D.. "Malignant paraganglioma and somatotropinoma in a patient with germline SDHB mutation—genetic and clinical features". Endocrine 63 1 (2019): 182-187. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053285572&partnerID=MN8TOARS.
    10.1007/s12020-018-1726-x
  21. Pereira, M.S.; Maia, L.; Azevedo, L.F.; Campos, S.; Carvalho, S.; Dias, A.M.; Albergaria, A.; et al. "A [Glyco]biomarker that Predicts Failure to Standard Therapy in Ulcerative Colitis Patients". Journal of Crohn's & colitis 13 1 (2019): 39-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057358772&partnerID=MN8TOARS.
    10.1093/ecco-jcc/jjy139
  22. Joana Peixoto; Jorge Lima. "Metabolic traits of cancer stem cells". Disease Models & Mechanisms 11 8 (2018): dmm033464-dmm033464. https://doi.org/10.1242/dmm.033464.
    10.1242/dmm.033464
  23. Ramalho, M.J.; Sevin, E.; Gosselet, F.; Lima, J.; Coelho, M.A.N.; Loureiro, J.A.; Pereira, M.C.. "Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment". International Journal of Pharmaceutics 545 1-2 (2018): 84-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046394917&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2018.04.062
  24. Almeida, L.M.C.A.; Silva, R.; Cavadas, B.; Lima, J.; Pereira, L.; Soares, P.; Sobrinho-Simões, M.; Lopes, J.M.; Máximo, V.. "GLUT1, MCT1/4 and CD147 overexpression supports the metabolic reprogramming in papillary renal cell carcinoma". Histology and Histopathology 32 10 (2017): 1029-1040. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021784421&partnerID=MN8TOARS.
    10.14670/HH-11-863
  25. Amorim-Pires, D.; Peixoto, J.; Lima, J.. "Hypoxia Pathway Mutations in Pheochromocytomas and Paragangliomas". Cytogenetic and Genome Research 150 3-4 (2017): 227-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014102461&partnerID=MN8TOARS.
    10.1159/000457479
  26. Batista, R.; Cruvinel-Carloni, A.; Vinagre, J.; Peixoto, J.; Catarino, T.A.; Campanella, N.C.; Menezes, W.; et al. "The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism". International Journal of Cancer 139 2 (2016): 414-423. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961644849&partnerID=MN8TOARS.
    10.1002/ijc.30057
  27. Oliveira, Patricia; Carvalho, Joana; Rocha, Sara; Azevedo, Mafalda; Vieira, Andre F.; Ferreira, Daniel; Mendes, Nuno; et al. "Epithelial-mesenchymal-epithelial transition induced by long term exposure to TGFB1 creates cellular heterogeneity". Cancer Research 76 (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000389969803119&KeyUID=WOS:000389969803119.
    10.1158/1538-7445.AM2016-1611
  28. Nunes, J.B.; Peixoto, J.; Soares, P.; Maximo, V.; Carvalho, S.; Pinho, S.S.; Vieira, A.F.; et al. "OXPHOS dysfunction regulates integrin-ß1 modifications and enhances cell motility and migration". Human Molecular Genetics 24 7 (2014): 1977-1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926488610&partnerID=MN8TOARS.
    10.1093/hmg/ddu612
  29. Melo, M.; Da Rocha, A.G.; Vinagre, J.; Batista, R.; Peixoto, J.; Tavares, C.; Celestino, R.; et al. "TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas". Journal of Clinical Endocrinology and Metabolism 99 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899908886&partnerID=MN8TOARS.
    10.1210/jc.2013-3734
  30. Martins-Mendes, D.; Monteiro-Soares, M.; Boyko, E.J.; Ribeiro, M.; Barata, P.; Lima, J.; Soares, R.. "The independent contribution of diabetic foot ulcer on lower extremity amputation and mortality risk". Journal of Diabetes and its Complications 28 5 (2014): 632-638. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906939504&partnerID=MN8TOARS.
    10.1016/j.jdiacomp.2014.04.011
  31. Vinagre, J.; Pinto, V.; Celestino, R.; Reis, M.; Pópulo, H.; Boaventura, P.; Melo, M.; et al. "Telomerase promoter mutations in cancer: An emerging molecular biomarker?". Virchows Archiv 465 2 (2014): 119-133. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905966100&partnerID=MN8TOARS.
    10.1007/s00428-014-1608-4
  32. Vinagre, J.; Almeida, A.; Pópulo, H.; Batista, R.; Lyra, J.; Pinto, V.; Coelho, R.; et al. "Frequency of TERT promoter mutations in human cancers". Nature Communications 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884524540&partnerID=MN8TOARS.
    10.1038/ncomms3185
  33. Celestino, R.; Lima, J.; Faustino, A.; Vinagre, J.; Maximo, V.; Gouveia, A.; Soares, P.; Lopes, J.M.. "Molecular alterations and expression of succinate dehydrogenase complex in wild-type kit/pdgfra/braf gastrointestinal stromal tumors". European Journal of Human Genetics 21 5 (2013): 503-510. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876668234&partnerID=MN8TOARS.
    10.1038/ejhg.2012.205
  34. Martins, R.G.; Nunes, J.B.; Máximo, V.; Soares, P.; Peixoto, J.; Catarino, T.; Rito, T.; et al. "A founder SDHB mutation in Portuguese paraganglioma patients". Endocrine-Related Cancer 20 6 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891402383&partnerID=MN8TOARS.
    10.1530/ERC-12-0399
  35. Lima, Jorge; Reis, Rui M.; Catarino, Telmo; Peixoto, Joana; Vinagre, Joao; Batista, Rui; Castro, Ligia; et al. "TERT promoter mutations in human gliomas". Molecular Cancer Therapeutics (2013): https://publons.com/wos-op/publon/7147037/.
    10.1158/1535-7163.TARG-13-C118
  36. Couto, J.P.; Daly, L.; Almeida, A.; Knauf, J.A.; Fagin, J.A.; Sobrinho-Simões, M.; Lima, J.; et al. "STAT3 negatively regulates thyroid tumorigenesis". Proceedings of the National Academy of Sciences of the United States of America 109 35 (2012): E2361-E2370. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871862427&partnerID=MN8TOARS.
    10.1073/pnas.1201232109
  37. Celestino, R.; Lima, J.; Faustino, A.; Máximo, V.; Gouveia, A.; Vinagre, J.; Soares, P.; Lopes, J.M.. "A novel germline SDHB mutation in a gastrointestinal stromal tumor patient without bona fide features of the Carney-Stratakis dyad". Familial Cancer 11 2 (2012): 189-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864662004&partnerID=MN8TOARS.
    10.1007/s10689-011-9499-x
  38. Máximo, V.; Lima, J.; Prazeres, H.; Soares, P.; Sobrinho-Simões, M.. "The biology and the genetics of Hürthle cell tumors of the thyroid". Endocrine-Related Cancer 19 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84864417959&partnerID=MN8TOARS.
    10.1530/ERC-11-0354
  39. Costa, B.M.; Viana-Pereira, M.; Fernandes, R.; Costa, S.; Linhares, P.; Vaz, R.; Pinheiro, C.; et al. "Impact of EGFR genetic variants on glioma risk and patient outcome". Cancer Epidemiology Biomarkers and Prevention 20 12 (2011): 2610-2617. http://www.scopus.com/inward/record.url?eid=2-s2.0-83055168559&partnerID=MN8TOARS.
    10.1158/1055-9965.EPI-11-0340
  40. Gonçalves, A.P.; Máximo, V.; Lima, J.; Singh, K.K.; Soares, P.; Videira, A.. "Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone". Biochimica et Biophysica Acta - Molecular Cell Research 1813 3 (2011): 492-499. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951906204&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2011.01.006
  41. Soares, Paula; Lima, Jorge; Almeida, Ana; Castro, Patrícia; Vinagre, João; Celstino, Ricardo; Couto, Joana Pinto; et al. "Genetic alterations in poorly differentiated and undifferentiated thyroid carcicomas". Current Genomics 12 8 (2011): 609-617. http://hdl.handle.net/1822/15574.
    10.2174/138920211798120853
  42. Pinto Couto, J.; Prazeres, H.; Castro, P.; Lima, J.; Maximo, V.; Soares, P.; Sobrinho-Simões, M.. "How molecular pathology is changing and will change the therapeutics of patients with follicular cell-derived thyroid cancer". Journal of Clinical Pathology 62 5 (2009): 414-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-66349089665&partnerID=MN8TOARS.
    10.1136/jcp.2008.055343
  43. Máximo, V.; Lima, J.; Soares, P.; Sobrinho-Simões, M.. "Mitochondria and cancer". Virchows Archiv 454 5 (2009): 481-495. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349114116&partnerID=MN8TOARS.
    10.1007/s00428-009-0766-2
  44. Máximo, V.; Lima, J.; Soares, P.; Silva, A.; Bento, I.; Sobrinho-Simões, M.. "GRIM-19 in health and disease". Advances in Anatomic Pathology 15 1 (2008): 46-53. http://www.scopus.com/inward/record.url?eid=2-s2.0-39149102905&partnerID=MN8TOARS.
    10.1097/PAP.0b013e31815e5258
  45. Sobrinho-Simões, M.; Máximo, V.; Rocha, A.S.; Trovisco, V.; Castro, P.; Preto, A.; Lima, J.; Soares, P.. "Intragenic Mutations in Thyroid Cancer". Endocrinology and Metabolism Clinics of North America 37 2 (2008): 333-362. http://www.scopus.com/inward/record.url?eid=2-s2.0-43849083525&partnerID=MN8TOARS.
    10.1016/j.ecl.2008.02.004
  46. Lima, J.; Feijão, T.; Da Silva, A.F.; Pereira-Castro, I.; Fernandez-Ballester, G.; Máximo, V.; Herrero, A.; et al. "High frequency of germline succinate dehydrogenase mutations in sporadic cervical paragangliomas in Northern Spain: Mitochondrial succinate dehydrogenase structure-function relationships and clinical-pathological correlations". Journal of Clinical Endocrinology and Metabolism 92 12 (2007): 4853-4864. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849056626&partnerID=MN8TOARS.
    10.1210/jc.2007-0640
  47. Máximo, V.; Botelho, T.; Capela, J.; Soares, P.; Lima, J.; Taveira, A.; Amaro, T.; et al. "Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid". British Journal of Cancer 92 10 (2005): 1892-1898. http://www.scopus.com/inward/record.url?eid=2-s2.0-20344366798&partnerID=MN8TOARS.
    10.1038/sj.bjc.6602547
  48. Máximo, V.; Lima, J.; Soares, P.; Botelho, T.; Gomes, L.; Sobrinho-Simões, M.. "Mitochondrial D-Loop instability in thyroid tumours is not a marker of malignancy". Mitochondrion 5 5 (2005): 333-340. http://www.scopus.com/inward/record.url?eid=2-s2.0-26444565256&partnerID=MN8TOARS.
    10.1016/j.mito.2005.06.003
  49. Lima, J.; Trovisco, V.; Soares, P.; Máximo, V.; Magalhães, J.; Salvatore, G.; Santoro, M.; et al. "Reply to: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas". Cancer Letters 230 1 (2005): 149-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144439247&partnerID=MN8TOARS.
    10.1016/j.canlet.2004.10.053
  50. Trovisco, V.; Soares, P.; Preto, A.; De Castro, I.V.; Lima, J.; Castro, P.; Máximo, V.; et al. "Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness". Virchows Archiv 446 6 (2005): 589-595. http://www.scopus.com/inward/record.url?eid=2-s2.0-21544464303&partnerID=MN8TOARS.
    10.1007/s00428-005-1236-0
  51. Lima, J.; Trovisco, V.; Soares, P.; Máximo, V.; Magalhães, J.; Salvatore, G.; Santoro, M.; et al. "BRAF mutations are not a major event in post-chernobyl childhood thyroid carcinomas". Journal of Clinical Endocrinology and Metabolism 89 9 (2004): 4267-4271. http://www.scopus.com/inward/record.url?eid=2-s2.0-4544324693&partnerID=MN8TOARS.
    10.1210/jc.2003-032224
  52. Lima, J; Soares, P; Maximo, V; Tronko, M; Bogdanova, T; Abrosimov, A; Thomas, G; Williams, D; Sobrinho-Simoes, M. "Mitochondrial DNA alterations in post-Chernobyl thyroid tumours". Biochimica et Biophysica Acta (BBA) - Bioenergetics (2004): https://publons.com/wos-op/publon/416093/.
  53. Lima, J.; Máximo, V.; Soares, P.; Williams, D.; Bogdanova, T.; Thomas, G.A.; Sobrinho-Simões, M.. "Re: Lohrer,H.D., Hieber,L. and Zitzelsberger,H. (2002) Differential mutation frequency in mitochondrial DNA from thyroid tumours. Carcinogenesis, 23, 1577-1582". Carcinogenesis 24 6 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0038011178&partnerID=MN8TOARS.
  54. Lima, J.; Teixeira-Gomes, J.; Soares, P.; Máximo, V.; Honavar, M.; Williams, D.; Sobrinho-Simões, M.. "Germline Succinate Dehydrogenase Subunit D Mutation Segregating with Familial Non-RET C Cell Hyperplasia". Journal of Clinical Endocrinology and Metabolism 88 10 (2003): 4932-4937. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242320354&partnerID=MN8TOARS.
    10.1210/jc.2002-030008
  55. Lima, J.; Máximo, V.; Soares, P.; Sobrinho-Simões, M.. "Letter to the editors [1]". Genes Chromosomes and Cancer 36 4 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0037376833&partnerID=MN8TOARS.
  56. Lima, J.; Máximo, V.; Soares, P.; Sobrinho-Simões, M.. "Alterations of the SDHD gene locus in midgut carcinoids.". Genes, chromosomes & cancer 36 4 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0037392478&partnerID=MN8TOARS.
  57. Soares, P.; Trovisco, V.; Rocha, A.S.; Lima, J.; Castro, P.; Preto, A.; Máximo, V.; et al. "BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC". Oncogene 22 29 (2003): 4578-4580. http://www.scopus.com/inward/record.url?eid=2-s2.0-0043170833&partnerID=MN8TOARS.
    10.1038/sj.onc.1206706
  58. Lima, J; Maximo, V; Soares, P; Sobrinho-Simoes, M. "Untitled". Genes, Chromosomes and Cancer (2003): https://publons.com/wos-op/publon/416109/.
    10.1002/GCC.10147
  59. Lesueur, F.; Corbex, M.; McKay, J.D.; Lima, J.; Soares, P.; Griseri, P.; Burgess, J.; et al. "Specific haplotypes of the RET proto-oncogene are over-represented in patients with sporadic papillary thyroid carcinoma". Journal of Medical Genetics 39 4 (2002): 260-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-18344384747&partnerID=MN8TOARS.
  60. Máximo, V.; Soares, P.; Lima, J.; Cameselle-Teijeiro, J.; Sobrinho-Simões, M.. "Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: A study with emphasis on Hürthle cell tumors". American Journal of Pathology 160 5 (2002): 1857-1865. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036095510&partnerID=MN8TOARS.

Other

Other output
  1. Integrated metabolomics and transcriptomics analysis of monolayer and neurospheres from glioblastoma cells. 2020. Peixoto, J.; Janaki-Raman, S.; Schlicker, L.; Schmitz, W.; Walz, S.; Herold-Mende, C.; Soares, P.; Schulze, A.; Lima, J.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85133885602&partnerID=MN8TOARS.
    10.21203/rs.3.rs-44975
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/07/01 Current Topics in cancer research - 3D models of cancer. 1st International Portugal-USA Summer Course in Cancer Research
(Lisboa, Portugal)
2024/06/30 Patient-derived organoids recapitulate the genomic and DNA methylation landscape of pediatric brain tumors 21st International Symposium On Pediatric Neuro-Oncology & SIOPE-BTG
(Philadelphia, United States)
2024/05/18 POPCARE: a nation-wide platform to speed up precision medicine in pediatric oncology 5th SIOP Europe Annual Meeting and 13th CCI Europe Conference
(Milano, Italy)
2024/04/29 POPCARE: Paediatric Oncology Precision Care Platform. 6th ASPIC International Congress
(Faro, Portugal)
2024/03/18 A Investigação de Translação Como Motor da Inovação. 2.ª Conferência - Economia, Desenvolvimento e Globalização
(Porto, Portugal)
2024/01 POPCARE: Pediatric Oncology Precision Care Platform 1º Encontro do National Cancer Hub
(Lisboa, Portugal)
2023/11 Molecular Tumour Boards Curso de Atualização em Medicina de Precisão
(Porto; Lisboa, Portugal)
2023/09 Fronteira da Medicina de Precisão: Novas Abordagens Terapêuticas. Congresso Nacional de Estudantes de Farmácia
(Porto, Portugal)
2023/05 Phaeochromocytoma/Paraganglioma Epidemiology and genetics Reunião Conjunta do GET-SR e GE-TNE: Paragangliomas (e Feocromocitomas)
(Luso, Portugal)
2023/04 Tumour-Derived Organoids in Paediatric Brain Tumours Beyond Remodel - 3R Models for Biomedical Research
(Porto, Portugal)
2023/03/24 Genetics and Targeted Therapy in Vascular Anomalies III Congresso Nacional de Anomalias Vasculares
(Porto, Portugal)
2023/02/03 PRECISEKIDS: resultados do perfil genómico de tumores cerebrais pediátricos em Portugal XIII CONGRESSO NACIONAL ASSOCIAÇÃO PORTUGUESA NEURO ONCOLOGIA
(Gaia, Portugal)
2023/01/27 PRECISEKIDS: A Platform for the Comprehensive Genomic Profiling of Paediatric Solid Tumours Sociedade de Hematologia e Oncologia Pediatrica
Hospital Pediatrico de Coimbra (Coimbra, Portugal)
2022/02 Applications of genomics in precision medicine Course in Molecular Genetics in Clinical Practice, Congresso Português de Endocrinologia
(Vilamoura, Portugal)
2022 Paragangliomas and Phaeochromocytomas – what’s new in genetics? X Advanced Course of Endocrinology
2022 NGS molecular pro¿le of paediatric brain tumours: results from 92 consecutive patients treated at Centro Hospitalar Universitário de São João 34th European Congress of Pathology
(Basel, Switzerland)
2022 PRECISEKIDS: resultados de um projecto nacional para a determinação do perfil genómico de tumores sólidos e anomalias vasculares pediátricas 19º Congresso Nacional de Oncologia
(Portugal)
2021/11 A single centre experience using the Oncomine Childhood Cancer Research Assay for paediatric solid tumours tumours: results from 106 consecutive paediatric patients Oncomine User Meeting Why to speed up NGS, Comprehensive panels and Hematology applications
2021/10 Molecular Biology Advances in Paediatric Oncology 43rd European Congress of Cytology
(Wroclaw, Poland)
2021/09 NGS molecular profile of paediatric brain tumours: results from consecutive patients treated at Centro Hospitalar Universitário de São João. 1º Congreso Ibérico de Hematología y Oncología pediátricas
2019/11 Investigação clínica e translacional em tumores pediátricos do sistema nervoso central ASPIC CONFERENCE. Investigação em Cancro Pediátrico: Onde estamos?
Gulbenkian (Lisbon, Portugal)
2017/06 Mutant metabolic enzymes and tumourigenesis FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications
FEBS (Figueira da Foz, Portugal)
2015/07 Hypoxia and its relevance in tumourigenesis and cancer therapy Post ASCO e WCGIC Meeting – metastatic colorectal cancer
Merck (Lisbon, Portugal)
2015/03 Paragangliomas and Phaeochromocytomas – a genetic perspective XXI Curso Pós-Graduado de Endocrinologia Diabetes e Metabolismo
(Porto, Portugal)
2012/04 SDH mutations in inherited neoplasias XXI Poto Cancer Meeting
(Porto, Portugal)
2012/01 Genetics of Paragangliomas and Pheochromocytomas, XIII Congresso Português de Endocrinologia XIII Congresso Português de Endocrinologia
(Coimbra, Portugal)
2008/05 NOVAS FORMAS FAMILIARES DE NEOPLASIAS TIROIDEIAS: O TEMPO DO PTEN, SDHS, GRIM19 III Fórum Ibérico de Anatomia Patológica
(Badajoz, Spain)
2005/05 Recent molecular studies of thyroid cancer and their correlation with pathological observations Jubilee Meeting of the ETA (European Thyroid Association)
European Thyroid Association (Athens, Greece)
2005/04 High frequency of germline SDHD and SDHB mutations in sporadic head and neck paragangliomas from northern Spain 96 th Annual Meeting of the American Association for Cancer Research
AACR (Anaheim, United States)
2005/02 Familial extra-adrenal paraganglioma as a consequence of a frameshift SDHB mutation 6th Portuguese Symposium on Endocrine Tumours
(Espinho, Portugal)
2003/10 Mutations in the mitochondrial genome in papillary cancers from Ukraine and Russia Workshop “Molecular biology of radiation-asociated thyroid cancer”, 4th edition of ETA-CRN (European Thyroid Association Cancer Research Network)
European Thyroid Association Cancer Research Network (Edinburgh, United Kingdom)
2003/10 Low frequency of B-raf mutations in post-Chernobyl thyroid carcinomas Workshop “Molecular biology of radiation-asociated thyroid cancer”, 4th edition of ETA-CRN (European thyroid association cancer research network)
European thyroid association cancer research network (Edinburgh, United Kingdom)
2003/03 SDHD mutation in a family with non-RET C-cell hyperplasia XII edition of Porto Cancer Meeting
Ipatimup (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09 - 2027/10 Dual-targeting nanoparticles for efficient drug repurposing in glioblastoma therapy
Co-supervisor
2022/11 - 2023/11 Generation of ex-vivo 3D organoid culture from surgically-derived tissue of paediatric brain tumours
Supervisor
 Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2016 Hypoxia pathway mutations in pheochromocytomas and paragangliomas
Supervisor
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2016 Clinical and biological implications of the c-met receptor in human glioblastoma
Supervisor
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2016 The metabolic regulation of the cancer stem cell phenotype in glioblastoma
Supervisor
 Biomedicina (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2014 Characterization of the reinin-angiotensin players in glioblastoma: potential application as biomarkers for bevacizumab-based therapy
Supervisor
 Neurociências (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2010 - 2014 Clinical and molecular effects of hyperbaric oxygen in diabetic foot ulcers
Co-supervisor
Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2013 The Metabolic Needs of Epithelial to Mesenchymal Transition
Supervisor
 Biomedicina (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2012 - 2013 Mutations in IDH1 and IDH2 in human gliomas: correlation with metabolic pathways
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
2010 - 2012 Genetic characterization of Pheochromocytomas
Supervisor
 Biologia (Master)
Universidade de Aveiro, Portugal
2008 - 2010 The Role of Mitochondrial Dysfunction in the Acquisition of the Warburg Effect in Tumour Cells
Supervisor
 Biologia (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/01 - Current "Tratar o cancro por Tu" a roadshow on cancer literacy across the country, in multiple cities, dealing with various types of cancer. (2023/01)
Conference (Co-organisor)
 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2023/10/26 - 2023/10/27 III ASPIC-ASEICA International Meeting. Cancer Immunology, Tumor Microenvironment and Metastasis (2023/10/26 - 2023/10/27)
Congress (Member of the Scientific Committee)
 Associação Portuguesa de Investigação em Cancro, Portugal
2022/06/30 - 2022/07/01 5th ASPIC International Congress (2022/06/30 - 2022/07/01)
Congress (Member of the Scientific Committee)
 Associação Portuguesa de Investigação em Cancro, Portugal
2022/05/12 - 2022/05/13 XXVIII Porto Cancer Meeting. Extracellular Vesicles, Cell Communication and Cancer: Time to Prick the Bubble (2022/05/12 - 2022/05/13)
Congress (Member of the Scientific Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/05/07 - 2020/05/08 XXVII Porto Cancer Meeting. Stemness & Metastasis: Advances in Research and Clinical Translation (2020/05/07 - 2020/05/08)
Congress (Member of the Scientific Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/05/02 - 2019/05/03 XXVI Porto Cancer Meeting. The Cancer Ecosystem: From Research to Pathology and Treatment (2019/05/02 - 2019/05/03)
Congress (Member of the Scientific Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/04/26 - 2018/04/27 XXV Porto Cancer Meeting. Cancer Wars: The Immune Force Awakens (2018/04/26 - 2018/04/27)
Congress (Member of the Scientific Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/05/11 - 2017/05/12 XXIV Porto Cancer Meeting. Liquid biopsy: bringing precision medicine closer to oncology (2017/05/11 - 2017/05/12)
Congress (Member of the Scientific Committee)
 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2015/05/07 - 2015/05/08 XXIII Porto Cancer Meeting. Stem Cells and Cancer (2015/05/07 - 2015/05/08)
Congress (Member of the Scientific Committee)
 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2013/04/11 - 2013/04/12 XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting. Translational Research in Cancer: Bringing Basic Science and Pathology to Clinical Oncology (2013/04/11 - 2013/04/12)
Congress (Member of the Scientific Committee)
 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2012/04/19 - 2012/04/20 XXI Porto Cancer Meeting. Metabolism and cancer - From etiopathogenesis to therapy (2012/04/19 - 2012/04/20)
Congress (Member of the Scientific Committee)
 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/05/17 Solving the unsolved in rare diseases: Hereditary diffuse gastric cancer
(Thesis) Arguer
 Jose Garcia Pelaez (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2023/10 Characterization and biological impact of medulloblastoma immune profile
(Thesis) Main arguer
 Rui Pedro Ferreira Marques (Master)
Universidade do Minho Escola de Ciências da Saúde, Portugal
2023/05 The role of 5-hydroxymethylcytosine as a potential epigenetic biomarker in a large series of thyroid neoplasms
(Thesis) Main arguer
 João Pedro Cerveira Gonçalves (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020 Mitochondrial complex II genetic characterization and enzymatic expression profile in tumours of the adrenal cortex and medulla Mariana Isabel Cerqueira Seco (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2017 Interplay between molecular and cellular players on glioma pathophysiology Joana Isabel Martins Cosme Vieira de Castro (PhD)
Universidade do Minho, Portugal
2016 Formas familiares de paragangliomas/feocromocitomas: perfil mutacional SDHx, rastreio pré-sintomático e impacto psicológico Raquel Margarida Gomes Martins (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2015 Avaliação da Expressão de Proteínas do Metabolismo energético e da sua Associação com Dados Clínico-patológicos de em doentes com Feocromocitmas e Paragangliomas.
(Thesis) Arguer
 Jose Carlos Oliveira Silva (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014 BIOLOGICAL IMPLICATIONS OF WNT6 EXPRESSION IN HUMAN GLIOBLASTOMA
(Thesis) Main arguer
 Daniela Sofia Moura Ferro (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 Estudo de biomarcadores em glioblastomas: correlação clínica e molecular. Paulo José de Campos Linhares Vieira (PhD)
Universidade do Porto Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2022/12/19 - Current European Society for Medical Oncology Member
2013 - Current Associação Portuguesa de Investigação em Cancro Member of the board
2013 - Current European Association for Cancer Research
2005 - Current American Association for Cancer Research

Committee member

Activity description
Role 		Institution / Organization
2022 - Current Coordinator of the Paediatric Cancer Group of the National Cancer Hub
Coordinator
2016 - 2018 Technical Advisory Group to the Portuguese Delegation of the Horizon 20202 (H2020) Societal Challenge 1 - Health Demographic Change and Well-Being
Advisor / Consultant
 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Conference scientific committee

Conference name Conference host
2024/04/29 - 2024/04/30 6th ASPIC International Congress

Consulting

Activity description Institution / Organization
2015 - Current Molecular diagnosis of adult and paediatric brain tumours Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2015 - Current Genetic diagnosis of hereditary forms of cancer Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/12/12 - Current Deciphering the Genetic Diversity of Paediatric Brain Tumours Programa de Doutoramento em Ciências da Saúde (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - 2024 “Metabolism and Cancer” integrated in the “Oncobiology Module of the Doctoral Programme in Molecular Medicine and Oncology” (Curso de doutoramento (conclusão de unidades curriculares))
2023/01/12 - 2023/01/12 Personalização da orientação terapêutica: o papel da investigação em Oncobiologia Curso de Onco-Biologia (Pós-Graduação) Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2016 - 2023 “Metabolismo tumoral como determinante à resposta terapêutica”, included in the “Unidade Curricular Optativa - Mitochondria and Pharmacology" (Licenciatura) Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2023 Translational Research in Central Nervous System Tumours”, included in the “Unidade Curricular Optativa – Neuro-Oncologia (Licenciatura) Universidade do Porto Faculdade de Medicina, Portugal
2012 - 2023 “Adrenal Medulla” integrated in the “Endocrinology Module of the Doctoral Programme in Molecular Medicine and Oncology” (Curso de doutoramento (conclusão de unidades curriculares))
2016 - 2022 “Metabolismo tumoral como determinante à resposta terapêutica”, included in the “Unidade Curricular Optativa - Mecanismos moleculares de resposta e resistência terapêutica em cancro" (Licenciatura) Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2020 Investigacao em Neuro-Oncologia; genética dos gliomas integrated in the Doctoral Programme in Neurosciences (Curso de doutoramento (conclusão de unidades curriculares))
2010 - 2012 “Cell Growth (proliferation, apoptosis and metabolism)” integrated in the “Oncobiology Module of the Programme for Advanced Medical Education – Doctoral Programme for Physicians” (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Porto Faculdade de Medicina, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2024/06 - 2024/07 PhD fellowships evaluator
Evaluator
 Fundação para a Ciência e a Tecnologia
2024/06 - 2024/06 Grant evaluator
Evaluator

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2022/01 Interview about being awarded with the Prémio Rui Osório de Castro/ Millennium BCP, for the generation of organoids from pediatric brain tumours Nortemédico

Interview (tv / radio show)

Program Topic
2024/05/16 - Current Porto Canal - Manhã Informativa Tratar o Cancro por Tu
2024/02/25 - 2024/02/25 Jornal da Noite POPCARE and Pediatric Cancer

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current Frontiers Molecular Biosciences
Distinctions

Award

2023 Precision Oncology Patient Innovation Awards
Bayer HealthCare AG, Germany
2022 Prémio Rui Osório de Castro-MillenniumBCP
2021 Best oral communication

Other distinction

2012 Congress Poster Prize
2012 Congress Poster Prize
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2005 Congress Poster Prize