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Renato is a Senior Scientist with 6 years of experience in the biotechnology industry and leading roles in the development and research studies of products in the fields of aesthetic/dermatology and skin regenerative medicine. Has a deep understanding of the preclinical drug development process and experience working with multidisciplinary teams in a translational setting. It has supervised and coordinate the scientific teams in the execution of different projects, being able to interact with multidisciplinary teams (regulatory affairs and production). Throughout its path Renato has always kept the focus in life sciences and the clinical applicability of its biomedical research. From its PhD in biological chemistry in 2014 up to now Renato has acquired a considerable array of technical competences in distinct research areas such as: Chemistry, Molecular and Cell Biology, data analysis, and in vivo testing. Additionally, he has also developed several soft skills from which he highlights leadership, critical thinking, problem-solving attitude, teamwork, and communication. Those skills were developed upon a rigorous work method as well as the ability to be critic and the need to understand beyond. He has also a strong ability to take leadership and collaborate in the design, execution, and project management activities. Author of 13 publications in peer-reviewed journals and two international patents in the field of skin regenerative medicine.
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Identification

Personal identification

Full name
Renato Manuel Soares Cardoso

Citation names

  • Cardoso, RMS

Author identifiers

Ciência ID
7216-2A08-072A
ORCID iD
0000-0002-1171-2084

Knowledge fields

  • Exact Sciences - Chemical Sciences
  • Exact Sciences - Chemical Sciences - Physical Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Beginner (A1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2014/01/14
Concluded
 Química (Doutoramento)
Major in Especialidade: Química Biológica
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Kinetics and Thermodynamics of Interaction Between Amphiphiles and Membranes: Interplay of Amphiphile Dipole Moment and Membrane Dipole Potential" (THESIS/DISSERTATION)
2008
Concluded
 Mestrado em Química Avançada (Mestrado)
Universidade de Coimbra, Portugal
"KINETICS AND THERMODYNAMICS OF INTERACTION OF A HOMOLOGOUS SERIES OF FLUORESCENT FATTY AMINES WITH LIPID BILAYERS" (THESIS/DISSERTATION)
 18
2002 - 2007
Concluded
 Licenciatura em Química de Processos Biológicos (Licenciatura)
Universidade de Coimbra, Portugal
"CINÉTICA E TERMODINÂMICA DA INTERACÇÃO ENTRE NBD-C12, A BSA E BICAMADAS LIPÍDICAS" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2014/04/01 - 2015/12/31 Postdoc (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/05/01 - 2014/01/14 Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Química de Coimbra, Portugal
2008/02/01 - 2009/04/30 Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Química de Coimbra, Portugal
2007/10/01 - 2008/07/31 Research Trainee (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Química de Coimbra, Portugal
2006/10/01 - 2007/07/31 Research Trainee (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Química de Coimbra, Portugal

Others

Category
Host institution 		Employer
2019/06/01 - Current Innovation Director LaserLeap Technologies, Portugal
LaserLeap Technologies, Portugal
2016/01/01 - 2019/05/31 Head of Lab Exogenus Therapeutics, S.A, Portugal
Exogenus Therapeutics, S.A, Portugal
Projects

Grant

Designation Funders
2014/04/01 - 2015/12/31 (project financed by QREN with number 4832 (StemCellBiotech))
4832
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Contract

Designation Funders
2020/09/01 - Current FOTOVID
49708
Researcher
Concluded
2019/06/01 - Current L.A.S.E.R.- P : Acoustic Laser to Scan, Examine and Remedy the Skin
|POCI-01-0247-FEDER-039704 / LISBOA-01-0247-FEDER039704
Researcher
2016/01/01 - 2019/05/31 Exo-Wound: Development and standardization of a advanced product for the treatment of chronic woundsExo
CENTRO-01-0247-FEDER-022398
Researcher
Concluded
2008/01/01 - 2011/12/30 Efeitos de ocupação molecular na cinética e termodinâmica da interacção de moléculas anfifílicas com proteinas e com membranas biológicas
PTDC/QUI/64565/2006
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade do Algarve, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2010/09/30 Modelação Quantitativa da Difusão Passiva Trans-citótica de Moléculas Anfifílicas através da Barreira Hemato-Encefálica
PTDC/SAU-FCF/69072/2006
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Filipe, Hugo A. L.; Cardoso, Renato M. S.; Loura, Luís M. S.; Moreno, Maria João. "Interaction of Amphiphilic Molecules with Lipid Bilayers: Kinetics of Insertion, Desorption and Translocation". In Membrane Organization and Dynamics, 49-89. Springer International Publishing, 2017.
    10.1007/978-3-319-66601-3_4
Conference abstract
  1. Cardoso, Renato Manuel Soares; Vaz, W. L. C.; Moreno, Maria João. "Effect of Amphiphile Dipole Moment in Solubility and Partition into Membranes". Paper presented in 9th European Biophysics Congress, Lisboa, 2013.
    Published
  2. Alves, A M; Cardoso, R. M. S.; Moreno, Maria João. "Molecular crowding effects on the structure and dynamics of a lipid bilayer". Paper presented in 9th European Biophysics Congress, Lisboa, 2013.
    Published
  3. Filipe, H. A. L.; Palmeira, Tiago; Cardoso, R. M. S.; Moreno, Maria João; Loura, LMS. "Location and fluorescent behavior of NBD-labeled fatty amines in POPC:Chol and SpM:Chol bilayers". Paper presented in 9th European Biophysical Congress, Lisboa, 2013.
    Published
  4. Cardoso, Renato Manuel Soares; Filipe, H. A. L.; Gomes, F.; Vaz, W. L. C.; Moreno, Maria João. "Characterization of a Homologous Series of Fluorescent Fatty Amines: Photophysics, Aqueous Solubility and Binding to Albumin and to POPC Bilayers". Paper presented in 54 Annual Meeting of Biophysical Society, San Francisco, 2010.
    Published
  5. Cardoso, Renato Manuel Soares; Gomes, Filipe; Martins, Patricia A. T.; Vaz, W. L. C.; Moreno, Maria João. "Effect of the acyl chain length on the translocation rate of Amphiphilic molecules in liquid disordered and liquid ordered lipid bilayers". Paper presented in 53 Annual Meeting of Biophysical Society, Boston, 2009.
    Published
  6. Cardoso, Renato Manuel Soares; Vaz, W. L. C.; Moreno, Maria João. "Kinetics and Thermodynamics of Interaction of a Homologous Series of Fluorescent Fatty Amines With Lipid Bilayers". Paper presented in 1st Portuguese-Spanish-Britsh Joint Biophysics Congress, Lisboa, 2008.
    Published
  7. Cardoso, Renato Manuel Soares; Vaz, W. L. C.; Moreno, Maria João. "Kinetics and Thermodynamics of the Interaction of C12-NBD fatty amine with Albumin and lipid Bilayers". Paper presented in 2ª Reunião Ibérica de Colóides e Interfaces, Coimbra, 2007.
    Published
Journal article
  1. Sílvia C. Rodrigues; Renato Cardoso; Patricia C. Freire; Cláudia F. Gomes; Duarte FV; Ricardo Pires das Neves; Simoes-Correia J. "Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders". International Journal of Molecular Sciences (2021): https://www.mdpi.com/1422-0067/22/18/9797.
    10.3390/ijms22189797
  2. Rodrigues, Silvia C.; Cardoso, Renato M. S.; Gomes, Claudia F.; Duarte, Filipe V.; Freire, Patricia C.; Neves, Ricardo; Simoes-Correia, Joana. "Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles". Membranes 11 9 (2021): 647. http://dx.doi.org/10.3390/membranes11090647.
    10.3390/membranes11090647
  3. Renato M. S. Cardoso; Silvia C. Rodrigues; Claudia F. Gomes; Filipe V. Duarte; Maryse Romao; Ermelindo C. Leal; Patricia C. Freire; Ricardo Neves; Joana Simões-Correia. "Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use". STEM CELLS Translational Medicine 10 6 (2021): 910-921. https://doi.org/10.1002/sctm.20-0376.
    10.1002/sctm.20-0376
  4. Rodrigues, Sílvia C.; Cardoso, Renato M. S.; Duarte, Filipe V.. "Mitochondrial microRNAs: A Putative Role in Tissue Regeneration". Biology 9 12 (2020): 486. http://dx.doi.org/10.3390/biology9120486.
    10.3390/biology9120486
  5. Cardoso, Renato M.S.; Martins, Patrícia A.T.; Ramos, Cristiana V.; Cordeiro, Margarida M.; Leote, Ricardo J.B.; Razi Naqvi, Kalbe; Vaz, Winchil L.C.; Moreno, Maria João. "Effect of dipole moment on amphiphile solubility and partition into liquid ordered and liquid disordered phases in lipid bilayers". Biochimica et Biophysica Acta (BBA) - Biomembranes 1862 3 (2020): 183157. http://dx.doi.org/10.1016/j.bbamem.2019.183157.
    Published • 10.1016/j.bbamem.2019.183157
  6. Henriques-Antunes, Helena; Cardoso, Renato M. S.; Zonari, Alessandra; Correia, Joana; Leal, Ermelindo C.; Jiménez-Balsa, Adrián; Lino, Miguel M.; et al. "The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration". ACS Nano 13 8 (2019): 8694-8707. http://dx.doi.org/10.1021/acsnano.9b00376.
    Published • 10.1021/acsnano.9b00376
  7. Martins, Patrícia A.T.; Domingues, Neuza; Pires, Cristiana; Alves, Ana Maria; Palmeira, Tiago; Samelo, Jaime; Cardoso, Renato; Velazquez-Campoy, Adrian; Moreno, Maria João. "Molecular crowding effects on the distribution of amphiphiles in biological media". Colloids and Surfaces B: Biointerfaces 180 (2019): 319-325. http://dx.doi.org/10.1016/j.colsurfb.2019.04.065.
    10.1016/j.colsurfb.2019.04.065
  8. Maleki, Hajar; Rai, Akhilesh; Pinto, Sandra; Evangelista, Marta; Cardoso, Renato M.S.; Paulo, Cristiana; Carvalheiro, Tiago; et al. "High Antimicrobial Activity and Low Human Cell Cytotoxicity of Core–Shell Magnetic Nanoparticles Functionalized with an Antimicrobial Peptide". ACS Applied Materials & Interfaces 8 18 (2016): 11366-11378. http://dx.doi.org/10.1021/acsami.6b03355.
    10.1021/acsami.6b03355
  9. Filipe, Hugo A. L.; Bowman, David; Palmeira, Tiago; Cardoso, Renato M. S.; Loura, Luís M. S.; Moreno, Maria João. "Interaction of NBD-labelled fatty amines with liquid-ordered membranes: a combined molecular dynamics simulation and fluorescence spectroscopy study". Physical Chemistry Chemical Physics 17 41 (2015): 27534-27547. http://dx.doi.org/10.1039/c5cp04191k.
    10.1039/c5cp04191k
  10. Martins, Patrícia T.; Velazquez-Campoy, Adrian; Vaz, Winchil L. C.; Cardoso, Renato M. S.; Valério, Joana; Moreno, Maria João. "Kinetics and Thermodynamics of Chlorpromazine Interaction with Lipid Bilayers: Effect of Charge and Cholesterol". Journal of the American Chemical Society 134 9 (2012): 4184-4195.
    Published • 10.1021/ja209917q
  11. Cardoso, Renato M. S.; Martins, Patricia A. T.; Gomes, Filipe; Doktorovova, Slavomira; Vaz, Winchil L. C.; Moreno, Maria Joa~o. "Chain-Length Dependence of Insertion, Desorption, and Translocation of a Homologous Series of 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-Labeled Aliphatic Amines in Membranes". The Journal of Physical Chemistry B 115 33 (2011): 10098-10108.
    Published • 10.1021/jp203429s
  12. Cardoso, R. M. S.; Filipe, H. A. L.; Gomes, F.; Moreira, N. D.; Vaz, W. L. C.; Moreno, M. J.. "Chain Length Effect on the Binding of Amphiphiles to Serum Albumin and to POPC Bilayers". The Journal of Physical Chemistry B 114 49 (2010): 16337-16346.
    Published • 10.1021/jp105163k

Intellectual property

Patent
  1. Cardoso, Renato. 2019. "Compositions comprising exosomes of umbilical cord blood cells useful control diseases related to immune system".
    Pending
  2. Cardoso, Renato. 2017. "Use of Umbilical Cord Blood Derived Exosomes for Tissue Repair".
    Granted/Issued
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2014 - 2014 4º PYChem
Conference (Other)
2013 - 2013 1º ENEQUI
Meeting (Other)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2013 - 2013 9th European Biophysics Congress
Congress
2010 - 2010 “54th Annual Meeting of Biophysical Society
Congress
2010 - 2010 53 Annual Meeting of Biophysical Society
Congress
2008 - 2008 1st Portuguese-Spanish-Britsh Joint Biophysics Congress
Congress
2007 - 2007 2ª Reunião Ibérica de Colóides e Interfaces
Congress
2006 - 2006 4º Workshop anual de Engenharia de Processos e Sistemas
Workshop
2006 - 2006 Jornada de Biomateriais
Conference
2006 - 2006 Medicinal Chemistry in the 21st Century
Congress
2005 - 2005 Protection and efficiency at the laboratory
Conference

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2010 - 2010 Systems Biology Aperfeiçoamento (Curso médio)
2007 - 2007 Biospectroscopy and Imaging Aperfeiçoamento (Curso médio)
2007 - 2007 Curso Livre de Alemão Inicial I Aperfeiçoamento (Curso médio)
2005 - 2005 Noções Básicas de Estatística Aperfeiçoamento (Curso médio)
2005 - 2005 Curso Livre de Calibração e Quantificação Aperfeiçoamento (Curso médio)
Distinctions

Other distinction

2008 Fundação para a Ciência e Tecnologia (FCT)- PhD Fellowship
2006 3% melhores alunos do ano de
Universidade de Coimbra, Portugal