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I have been involved in breast cancer research for 20 years. Initially, I worked at Medical School of the University of São Paulo, Discipline of Radiology and Oncology, Laboratory of Molecular Genetics under the supervision of Dr. Maria Aparecida Nagai from March 1999 to June 2017. The Dr. Nagai' s group aims to combine omics data integration and functional studies for the identification of pathways and biomarkers that may become useful molecular descriptors for diagnosis, prognosis, and therapy of breast cancer. In this context, I had the opportunity to participate in the “The Human Cancer Genome Project Sequencing Consortium” supported by FAPESP/LICR and gained expertise in molecular genetics and sequencing techniques (Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13418-23). The group also focuses on the study of the functional role of oncogenes and tumor suppressor genes in the process of morphogenesis of the mammary gland in 3D culture and the chemosensitivity of breast cancer cells to chemotherapeutic agents . During the first 2 years (1999 – 2001) in Dr. Nagai´s lab, I concluded a latu sensu graduate program in Oncogenes and Tumor Suppressor Genes, developing the project entitled “Analysis of TP53 gene alterations in primary prostate carcinomas” and worked on the “The Human Cancer Genome Project Sequencing Consortium”. Next, I entered the graduate program obtaining my master´s degree (2001-2004) in Biotechnology, with the project “Effect of 17ß-estradiol on HNRPK, PAWR, RBBP4, ATRX and TLN1 expression in MCF-7 breast cancer cell line” and the doctorate degree (2005-2009), in the same area, with the PhD thesis entitled “Study to evaluate the crosstalk between estrogens and growth factors pathways on the transcriptional regulation of HNRPK, PAWR and PHLDA1”. In 2010, I was hired as Laboratory Specialist of the Molecular Genetics Laboratory maintaining my important participation in the scientific production of Dr. Nagai´s group. During this time as Laboratory Specialist, I actively participated in the training and support for 2 Latu Sensu students, 5 master students, 3 doctorate students and 1 postdoc researcher. Additionally, I acted as monitor in practical classes of the bachelor and graduate disciplines under the responsibility of Dr. Maria Aparecida Nagai. In 2017, I moved to Portugal with my family and started my activities as a PostDoc research fellow in Cell Growth and Differentiation Group (IBMC / i3S) under the mentorship of R. Freitas and working on the role of HOX genes in breast cancer. In summary, I paticipated in 8 projetcs writing/management and students’ support, published 11 papers, 4 as first author, and acquired an extensive experience and autonomy in cellular and molecular biology techniques(qPCR, western blot, transfection assays), cell culture (in 2D and 3D), functional and, more recently, animals studies (Felasa funcitons A and D). Moreover, my scientific production was also disseminated by the 32 poster presentations and 6 talks that I made. Now, we have a review article under revision to publication in BBA reviews on Cancer and an original article under preparation. It is noteworthy, that my PhD degree was recognized by Universidade do Porto under the registration number 220190010186
Identification

Personal identification

Full name
Simone Aparecida de Bessa Garcia

Citation names

  • Garcia, Simone
  • de Bessa, S. A.
  • Bessa, S. A.
  • de Bessa Garcia, S. A.
  • Bessa Garcia, S. A.
  • Garcia, S. A. B.

Author identifiers

Ciência ID
721B-5D38-832C
ORCID iD
0000-0002-7122-7339

Email addresses

  • sabessa@gmail.com (Professional)

Telephones

Telephone
  • 220408800 (Professional)

Addresses

  • i3S - Instituto de Biologia Molecular e Celular (IBMC). Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

  • https://orcid.org/0000-0002-7122-7339 (Professional)

Knowledge fields

  • Medical and Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2021/02/27 - 2021/04/17
Concluded
Medical Affairs and Medical Markenting (Diploma de especialização)
Invictus Sciences, Portugal
2020/12/05 - 2021/02/20
Concluded
Regulatory Affairs and Technical Direction (Diploma de especialização)
Invictus Sciences, Portugal
2019/10 - 2020/03
Concluded
Introductory Course in Laboratory Animal Science (mice and rats), 26º edition (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/07 - 2017/07
Concluded
Course in Laboratory Animals and Experimental Research (Outros)
Central Bioterium of the Faculty of Medicine of the University of São Paulo (FMUSP). , Brazil
2017/03 - 2017/03
Concluded
Operational training in the microscopy platform EVOS FL Auto Imaging (Outros)
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
2016/06 - 2016/06
Concluded
Capacitation Course “Innovation in Cancer Research” (Outros)
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
2016/06 - 2016/06
Concluded
Course of biosafety in research with genetically modified organisms (Outros)
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
2015/01 - 2015/01
Concluded
Operational training in Attune and Autosampler platforms. (Outros)
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
2015/01 - 2015/01
Concluded
Summer Course in Cancer Systems Biology (Outros)
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
2013/02 - 2013/02
Concluded
Mini-course in 3D culture and mammary gland tumour engraftment as models for studying the biology and therapeutics. (Outros)
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
2005 - 2009
Concluded
Interunits in Biotechnology USP/Instituto Butantan/IPT (Doctor)
Universidade de São Paulo, Brazil
"Study to evaluate the crosstalk between estrogens and growth factors pathways on the transcriptional regulation of HNRPK, PAWR and PHLDA1" (THESIS/DISSERTATION)
Approved
2008/09 - 2008/09
Concluded
Training in Real Time PCR (Outros)
Applied Biosystems do Brasil Ltda, Brazil
2006/01 - 2006/02
Concluded
Training in Analysis of fragments in the MegaBACE Platform (Outros)
Laboratory of Investigation in Dermatology and Immunodeficiencies – LIM 56. Faculty of Medicine of the University of São Paulo –FMUSP, Brazil
2001 - 2004
Concluded
Interunits in Biotechnology USP/Instituto Butantan/IPT (Mestrado)
Universidade de São Paulo, Brazil
"Effect of 17ß-estradiol on HNRPK, PAWR, RBBP4, ATRX and TLN1 expression in MCF-7 breast cancer cell line" (THESIS/DISSERTATION)
Approved
2002/08/17 - 2002/08/17
Attended
Clinical use of the genetics' tests (Outros)
Instituto deEnsino e Pesquisa Albert Einstein, Brazil
2000/05/08 - 2000/05/11
Concluded
Introductory Course to the Oncology League (Outros)
Universidade de São Paulo Faculdade de Medicina, Brazil
1999 - 2000
Concluded
Specialization Program in Oncogenes and Tumor Suppressor Genes (Postgraduate Certificate)
Universidade de São Paulo Hospital das Clínicas, Brazil
Approved
1999
Concluded
Professor Formation (Licence)
Universidade São Judas Tadeu, Brazil
"n/a" (THESIS/DISSERTATION)
Approved
1999
Concluded
Biological Sciences (Bachelor)
Universidade São Judas Tadeu, Brazil
"n/a" (THESIS/DISSERTATION)
Approved
Affiliation

Science

Category
Host institution
Employer
2021/02/08 - 2022/09/30 Researcher (Research) Phyzat Biopharmaceuticals, Portugal
2017/12/15 - 2021/02/06 Postdoc (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Others

Category
Host institution
Employer
2023/01 - Current Senior Research Technician Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
(...)
2010/01/26 - 2017/06/14 Laboratory Specialist. Main Activities:perform, with the professors, studies and procedures related to teaching, research and extension activities (exception to didactic activities) Universidade de São Paulo Instituto de Radiologia, Brazil
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
2001/10/08 - 2002/06/04 Biologist. Main Activities: sample preparation for sequencing in MegaBACE and ABI 377 platforms. Equipments operation. Data analysis and delivery. Universidade de São Paulo Hospital das Clínicas, Brazil
Projects

Grant

Designation Funders
2023/01 - Current Unlocking excellence in research and innovation in neurobiology and neurological disorders at IBMC/I3
H2020-WIDESPREAD-2018-2020-6-951923_NCBio
Research Technician Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing
2018 - Current HOXB genes function in breast cancer
POCI-01-0145-FEDER-030562
Post-doc Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/12/15 - Current The HOXOME of cancer
NORTE-01-0145-FEDER-000029
Research Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2021/02 - 2022/09 SIRNAC - NOVEL siRNA THERAPIES AGAINST METASTATIC COLORECTAL CANCER
SIRNAC
Researcher
Phyzat Biopharmaceuticals, Portugal
Ongoing
2021/02 - 2022/09 SIRNAGLAU - NOVEL siRNA THERAPIES AGAINST GLAUCOMA
SIRNAGLAU
Researcher
Phyzat Biopharmaceuticals, Portugal
Ongoing
2021/02 - 2022/09 SIRNACOVID - NOVEL siRNA THERAPY AGAINST COVID
SIRNACOVID
Researcher
2015 - 2017 Functional role of the PHLDA1, RET, BCAR3 and Progesterone Receptor isoform A (PRA) genes in breast cancer: clinical implications.
15/10208-3
Research Fellow
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2013 - 2017 Role of PAR-4 (prostate apoptosis response-4) expression in breast tumorigenesis: implications for chemosensitivity and antitumor potential.
13/07035-4
Research Fellow
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2010 - 2015 Study of the PAR-4 and SPARC genes functional role in breast cancer survival and chemosensitivity
10/16543-5
Research Fellow
Universidade de São Paulo Faculdade de Medicina, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2006 - 2011 Functional analysis of genes potentially regulated by the estrogen receptor and / or the oncogene ERBB2: implications in the diagnosis, prognosis and treatment of breast cancer and chemioresistance
06/01026-0
Research Fellow
Universidade de São Paulo Faculdade de Medicina, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2003 - 2008 Validation and characterization of genes differentially expressed in breast cancer: Interaction between estrogen and growth factors signaling pathways
03/13170-0
Research Fellow
Universidade de São Paulo Faculdade de Medicina, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2000 - 2001 Human Cancer Genome Program: central laboratory for sequencing
99/04474-8
Research Technician Fellow
Universidade de São Paulo Faculdade de Medicina, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
Outputs

Publications

Book chapter
  1. De Bessa-Garcia, S.A.; Nagai, M.A.. "Involvement of Par-4 in breast cancer". 113-131. 2022.
Conference abstract
  1. Garcia, Simone; Pavanelli, Ana C.; Melo, Natalia C.; Nagai, Maria A.. "Abstract 3803: Transcriptome analysis of MCF7 breast cancer cells with different expression profile of PAR-4 (prostate apoptosis response-4) in the presence and absence of docetaxel". Paper presented in 106th Annual Meeting of the American Association for Cancer Research. Journal: Cancer Res., Philadelphia, 2015.
    Published • 10.1158/1538-7445.am2015-3803
  2. de Bessa Garcia, S. A.; Pereira, M.C.; Burikhanov, Ravshan; Pavanelli, Ana Carolina; Antunes, Lourival; Rangnekar, Vivek M.; Nagai, M. A.. "PAR-4 (prostate apoptosis response-4) modulates cell survival and chemosensitivity to docetaxel in MCF-7 breast cancer cells". Paper presented in ESPCA - Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment. Journal: Clinics, São Paulo, 2013.
    Published
  3. Bonatto, N.; de Bessa Garcia, S. A.; Nagai, M.A.. "Estrogen and growth factors modulates PHLDA1 expression in MCF7 breast cancer cells". Paper presented in ESPCA - Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment. Journal: Clinics, São Paulo, 2013.
    Published
  4. Pereira, M. C.; Bessa-Garcia, S. A. d.; Nagai, M. A.. "Abstract A50: PAR-4 (prostate apoptosis response-4) modulates cell survival and chemosensitivity to docetaxel in MCF-7 breast cancer cells". Paper presented in 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research. Journal: Cancer Prev. Res., Philadelphia, 2012.
    Published • 10.1158/1940-6207.prev-12-a50
  5. de Bessa-Garcia, Simone A.; Pereira, Michelly C.; Nagai, Maria A.. "Abstract 2887: Regulation of PAR-4 and PHLDA1 expression by estrogen and epidermal growth factor in MCF-7 breast cancer cells". Paper presented in 102nd Annual Meeting of the American Association for Cancer Research. Journal: Cancer Res., Orlando, 2011.
    Published • 10.1158/1538-7445.am2011-2887
  6. Garcia, Simone; Pereira, Michelly C.; Nagai, Maria A.. "Role of the tumor suppressor gene PAR-4 in mammary gland morphogenesis and breast cancer". Paper presented in 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine. Journal: Int J Mol Med, Rhodes, 2011.
    Published
  7. de Bessa Garcia, S. A.; Pereira, M. C.; Nagai, M. A.. "Role of the tumor suppressor gene PAR-4 on cell proliferation, survival and morphogenesis of mammary epithelial cells MCF10A and breast cancer cells MCF-7". Paper presented in 39th Annual meeting of the ISOBM. Journal: Tumor Biol, Firenze, 2011.
    Published
  8. Garcia, Simone; Pereira, Michelly C.; Nagai, Maria A.. "PAR-4 and PHLDA1 expression regulation by estrogen and epidermal growth factor in MCF-7 breast cancer cells". Paper presented in 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine. Journal: Int J Mol Med, Rhodes, 2011.
  9. Garcia, Simone; Pereira, M. C.; Nagai, M. A.. "Regulation of PAWR expression by estrogen and growth factors in breast cancer cells". Paper presented in 14th World Congress Advances in Oncology, and 12th International Symposium on Molecular Medicine. Journal: Int J Mol Med, Loutraki, 2009.
    Published
  10. Nagai, M. A.; Garcia, Simone; Salaomi, S.; Fregnani, J. H.; Nonogaki, S.; Netto, M. M.; Soares, F. A.. "Down-regulation of nuclear PAWR expression in primary breast cancer is correlated with poor prognosis". Paper presented in 14th World Congresso n Advances in Oncology, and 12th International Symposium on Molecular Medicine. Journal: Int J Mol Med, Loutraki, 2009.
    Published
  11. de Bessa Garcia, S. A.; Pereira, M. C.; Nagai, M.A.. "Expression pattern of the pro-apoptotic genes PHLDA1 and PAWR during the morphogenesis of MCF-10A human mammary epithelial cells". Paper presented in 5th International Conference on Tumor Microenvironment: Progression, Therapy, and Prevention. Journal: Cancer Microenviron, Versailes, 2009.
    Published
  12. Santos, E. S; Salaorni, S; de Bessa Garcia, S. A.; da Silva Gomes, V. C.; Marchiori, A. C.; Casolari, Debora A.; Proto, D. R.; Netto, M. M.; Nagai, M. A.. "The transcripts of a bidirectional pair of genes, lrrc49/thap10, are frequently down-regulated in primary breast tumors". Paper presented in 3rd Symposium advances in medical research. Journal: Clinics, São Paulo, 2007.
    Published
  13. De Souza Santos, E.; Salorni, S.; de Bessa Garcia, S. A.; Silva, V. C. G.; Marchiori, A. C.; Casolari, D. A.; Perez, D. R. V.; Netto, M. M.; Nagai, M. A.. "The transcripts of a bidirectional pair of genes, lrrc49/thap10, are frequently down-regulated in primary breast tumors". Paper presented in 3rd Symposium advances in Medical research. Journal: Clinics, São Paulo, 2007.
  14. dos Santos, M. L.; de Bessa Garcia, S. A.; Neto, M. M; Silva, W. A. Jr.; Nagai, M. A.. "Differentially expressed genes associated with ERBB2 over-expression in human mammary cells in response to docetaxel". Paper presented in 9th International Symposium on Molecular Medicine, 11th World Congress on Advances in Oncology. Journal: Int J Mol Med, Creta, 2006.
    Published
  15. dos Santos, M. L.; de Bessa Garcia, S. A.; Perez, D. R. V.; Mourão, M. M.; Soares, F. A.; Silva Jr, W. A.; Nagai, M.A.. "Identification of Differentially Expressed Genes Associated with ERBB2 Over-expression in Human Mammary Cells in Response to Docetaxel". Paper presented in IV São Paulo Research Conference Cancer Today: From Molecular Biology to Treatment. Journal: Applied Cancer Resarch Supplement, São Paulo, 2005.
    Published
  16. de Bessa Garcia, S. A.; Soares, F. A.; Mourão, M. M.; Nagai, M. A.. "Increased expression of PAWR is associated with breast cancer progression". Paper presented in IV São Paulo Research Conference Cancer Today: From Molecular Biology to Treatment. Journal: Applied Cancer Research Supplement, São Paulo, 2005.
    Published
  17. de Bessa Garcia, S. A.; Nagai, M.A.. "Opposing action of 17B-estradiol on HNRPK and PAWR gene expression". Paper presented in 9th World Congress on Advances in Oncology, 7th International Symposium on Molecular Medicine. Journal: Int J Mol Med, Creta, 2004.
    Published
Journal article
  1. Pavanelli, Ana Carolina; Mangone, Flavia Rotea; Yoganathan, Piriya; Bessa, Simone Aparecida; Nonogaki, Suely; de Toledo Osório, Cynthia A. B.; de Andrade, Victor Piana; et al. "Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes". Breast Cancer Research and Treatment 192 1 (2022): 43-52. http://dx.doi.org/10.1007/s10549-021-06452-9.
    10.1007/s10549-021-06452-9
  2. de Bessa Garcia, S. A.; Araújo, Mafalda; Pereira, Tiago; Freitas, Renata. Corresponding author: Freitas, Renata. "HOXB7 Overexpression Leads Triple-Negative Breast Cancer Cells to a Less Aggressive Phenotype". Biomedicines 9 5 (2021): 515. http://dx.doi.org/10.3390/biomedicines9050515.
    10.3390/biomedicines9050515
  3. "Roles of the HOX Proteins in Cancer Invasion and Metastasis.". Cancers (2020): https://europepmc.org/articles/PMC7792759.
    10.3390/cancers13010010
  4. "Methylation in HOX Clusters and Its Applications in Cancer Therapy". Cells (2020): http://dx.doi.org/10.3390/cells9071613.
    10.3390/cells9071613
  5. Simone Aparecida de Bessa Garcia; Mafalda Araújo; Renata Freitas. "Dataset of HOXB7, HOXB8 and HOXB9 expression profiles in cell lines representative of the breast cancer molecular subtypes Luminal a (MCF7), Luminal b (BT474), HER2+ (SKBR3) and triple-negative (MDA231, MDA468), compared to a model of normal cells (MCF10A)". Data in Brief 30 (2020): 105572-105572. https://doi.org/10.1016/j.dib.2020.105572.
    10.1016/j.dib.2020.105572
  6. de Bessa Garcia, S. A.. "HOX genes function in Breast Cancer development". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (2020): http://dx.doi.org/10.1016/j.bbcan.2020.188358.
    10.1016/j.bbcan.2020.188358
  7. de Alcantara Filho, Paulo R; Mangone, Flavia R; Pavanelli, Ana C; de Bessa Garcia, Simone A; Nonogaki, Suely; de Toledo Osório, Cynthia AB; de Andrade, Victor P; Nagai, Maria A. "Gene expression profiling of triple-negative breast tumors with different expression of secreted protein acidic and cysteine rich (SPARC)". Breast Cancer Management 7 2 (2018): BMT09. http://dx.doi.org/10.2217/bmt-2017-0019.
    Published • 10.2217/bmt-2017-0019
  8. Bonatto, N.; Carlini, M.J.; de Bessa Garcia, S.A.; Nagai, M.A.. "PHLDA1 (pleckstrin homology-like domain, family A, member 1) knockdown promotes migration and invasion of MCF10A breast epithelial cells". Cell Adhesion and Migration (2017): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021683294&partnerID=MN8TOARS.
    10.1080/19336918.2017.1313382
  9. De Bessa Garcia, S.A.; Pavanelli, C.; Melo, N.C.E.; Nagai, M.A.. "Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity". International Journal of Molecular Medicine 39 4 (2017): 809-818. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018505565&partnerID=MN8TOARS.
    10.3892/ijmm.2017.2900
  10. Pereira, Michelly C.; De Bessa-Garcia, Simone A.; Burikhanov, Ravshan; Pavanelli, Ana Carolina; Antunes, Lourival; Rangnekar, Vivek M.; Nagai, Maria A.. "Prostate apoptosis response-4 is involved in the apoptosis response to docetaxel in MCF-7 breast cancer cells". International Journal of Oncology 43 2 (2013): 531-538. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000321937100020&KeyUID=WOS:000321937100020.
    10.3892/ijo.2013.1983
  11. Garcia, S. A. B.; Nagai, M. A.. "Transcriptional regulation of bidirectional gene pairs by 17 beta-estradiol in MCF-7 breast cancer cells". Brazilian Journal of Medical and Biological Research 44 2 (2011): 112-122. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000287139000005&KeyUID=WOS:000287139000005.
    10.1590/S0100-879X2010007500149
  12. Casolari, Debora A.; Pereira, Michelly C.; De Bessa Garcia, Simone A.; Nagai, Maria A.. "Insulin-like growth factor-1 and 17 beta-estradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells". International Journal of Molecular Medicine 28 3 (2011): 337-342. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000293603100006&KeyUID=WOS:000293603100006.
    10.3892/ijmm.2011.691
  13. Garcia, Simone; Pereira, M.C.; Nagai, M.A.. "Expression pattern of the pro-apoptotic gene PAR-4 during the morphogenesis of MCF-10A human mammary epithelial cells". Cancer Microenvironment 4 1 (2011): 33-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952537281&partnerID=MN8TOARS.
    10.1007/s12307-010-0059-y
  14. Emerson De Souza Santos; Simone De Bessa; Mario Netto; Maria Nagai. "Silencing of LRRC49 and THAP10 genes by bidirectional promoter hypermethylation is a frequent event in breast cancer". International Journal of Oncology 33 1 (2008): 25-31. https://doi.org/10.3892%2Fijo.33.1.25.
    Published • 10.3892/ijo.33.1.25
  15. Santos, Emerson De Souza; De Bessa, Simone A.; Netto, Mario M.; Nagai, Maria A.. "Silencing of LRRC49 and THAP10 genes by bidirectional promoter hypermethylation is a frequent event in breast cancer". International Journal of Oncology 33 1 (2008): 25-31. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000257276200003&KeyUID=WOS:000257276200003.
  16. De Bessa, SA; Salaorni, S; Patrao, DFC; Neto, MM; Brentani, MM; Nagai, MA. "JDP1 (DNAJC12/Hsp40) expression in breast cancer and its association with estrogen receptor status". International Journal of Molecular Medicine 17 2 (2006): 363-367. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000234760900025&KeyUID=WOS:000234760900025.
  17. De Bessa, S.A.; Salaorni, S.; Patrão, D.F.C.; Neto, M.M.; Brentani, M.M.; Nagai, M.A.. "JDP1 (DNAJC12/Hsp40) expression in breast cancer and its association with estrogen receptor status". International Journal of Molecular Medicine 17 2 (2006): 363-367. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644865047&partnerID=MN8TOARS.
    10.3892/ijmm.17.2.363
  18. Brentani, H; Caballero, OL; Camargo, AA; da Silva, AM; da Silva, WA; Neto, ED; Grivet, M; et al. "The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 100 23 (2003): 13418-13423. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000186573700056&KeyUID=WOS:000186573700056.
    10.1073/pnas.1233632100
  19. Nagai, MA; Ros, N; Bessa, SA; Neto, MM; Miracca, EC; Brentani, MM. "Differentially expressed genes and estrogen receptor status in breast cancer". International Journal of Oncology 23 5 (2003): 1425-1430. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000185984700024&KeyUID=WOS:000185984700024.

Other

Other output
  1. HOXB7 overexpression leads triple-negative breast cancer cells to a less aggressive phenotype. 2021. de Bessa Garcia, S.A.; Araújo, M.; Pereira, T.; Freitas, R.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85166686536&partnerID=MN8TOARS.
    10.21203/rs.3.rs-147853/v1
  2. HOXB7 and HOXB8 function in Breast Cancer. In: Porto Cancer Meeting.. 2019. de Bessa Garcia, S. A.; Araújo, Mafalda; Freitas, Renata.
  3. HOXB genes function in Breast Cancer. In: IJUP. 2019. Araújo, Mafalda; de Bessa Garcia, S. A.; Tiago Pereira; João Mouta; Salta, S; Carmen Jerónimo; Freitas, Renata.
  4. Impact of HOXB deregulation in Breast Cancer. In: I3S Annual Meeting.. 2018. Araújo, Mafalda; de Bessa Garcia, S. A.; Tiago Pereira; João Mouta; Carmen Jerónimo; Freitas, Renata.
  5. The HOXB genes function in Breast Cancer. In: 2018 Frontiers in Cancer Research.. 2018. Araújo, Mafalda; de Bessa Garcia, S. A.; Freitas, Renata.
  6. Prostate apoptosis response-4 (PAR4) secretion in breast tumor and normal cell lines cultured in hypoxic conditions. In: AACR International Conference. Translational Cancer Medicine. 2017. de Bessa Garcia, S. A.; Irina Gueroldovna Brobovnitchaia; Flavia Rotea Mangone; Maria Aparecida Nagai.
  7. ATM Gene Mutations in Sporadic Breast Cancer Patients from Brazil. 58 Brazilian Genetics Congress. 2012. de Bessa Garcia, S. A.; Urias, U.; Nagai, M. A..
  8. Effects of estrogen and epidermal growth factor on the regulation of PHLDA1 expression in breast cancer cells. In: 2010 Keystone Symposia Nuclear Receptors: Signaling, Gene Regulation, and Cancer. 2010. de Bessa Garcia, S. A.; Nagai, M. A..
  9. Estudo da interação entre as vias de sinalização dos estrógenos e fatores de crescimento no controle da transcrição dos genes PAWR e PHLDA1. In: 55° Congresso Brasileiro de Genética. 2009. de Bessa Garcia, S. A.; Pereira, M.C.; Nagai, M. A..
  10. Effects of 17b-estradiol on the expression of bi-directional gene pairs in MCF-7 breast cancer cells. In: 100th AACR Annual Meeting. 2009. de Bessa Garcia, S. A.; Nagai, M. A..
  11. Identification of new estrogen receptor candidate target genes. In: Advances in Cancer Research: From the Laboratory to the Clinic,. 2008. de Bessa Garcia, S. A.; Ana Carolina Marchiori; Nagai, M. A..
  12. High expression of PAWR is Associated with breast cancer progression. In: AACR Special Conference Proceedings Advances in Breast Cancer research. 2007. de Bessa Garcia, S. A.; Soares, F. A.; Mourão Neto, M.; Nagai, M. A..
  13. Silencing of LRRC49 and THAP10 genes by bidirectional promoter hypermethylation is a frequent event in breast cancer. In: American Association for Cancer Research Annual Meeting. 2007. de Bessa Garcia, S. A.; Vivian Carla da Silva; Ana Carolina Marchiori; Debora Casolari; Diana Perez; Mario Mourão Netto; Nagai, M. A..
  14. Expression pattern of the JDP1 (DNAJC12/HSP40) Gene in Primary Breast Tumors and its Assocoated with estrogen receptor (ER) Status. In: 2º Simpósio Avanços de Pesquisas Médicas dos Laboratórios de Investigação Médica. 2005. de Bessa Garcia, S. A.; Salaorni, S.; Patrão, D. F.; Netto, M. M.; Brentani, M. M; Nagai, M. A..
  15. Search for Estrogen-Responsive Elements in the Promoter Region of ER Candidate Target Genes. In: 2º Simpósio Avanços de Pesquisas Médicas dos Laboratórios de Investigação Médica. 2005. Nagai, M. A.; Marchiori, A. C.; de Bessa Garcia, S. A.; Patrão, D. F..
  16. Effects of 17B-Estradiol on the Expression of HNRPK and PAWR Genes. In: 2º Simpósio Avanços de Pesquisas Médicas dos Laboratórios de Investigação Médica. 2005. Nagai, M. A.; de Bessa Garcia, S. A..
  17. Estrogen regulation of HNPRK and PAWR gene expression in breast cancer cells. In: 50° Congresso Brasileiro de Genética. 2004. de Bessa Garcia, S. A.; Nagai, M. A..
  18. Annotation of the human chromosome region 17p13 using expressend sequence tags (ESTs). In: 1º Simpósio Avanços de Pesquisas Médicas dos Laboratórios de Investigação Médica. Poster presentation at 1º Simpósio Avanços de Pesquisas Médicas dos Laboratórios de Investigação Médica (São Paulo - Brazil). 2003. Acencio, M. L.; Coutinho-Camillo, C. C.; de Bessa Garcia, S. A.; Buim, M. E.; Miracca, E. C.; Rós, N.; Santos, M. L.; et al.
  19. Analysis of breast cancer cell lines expression pattern with ORF tags expressed sequence. In: 1º Simpósio Avanços de Pesquisas Médicas dos Laboratórios de Investigação Médica. Poster presentation at 1º Simpósio Avanços de Pesquisas Médicas dos Laboratórios de Investigação Médica (São Paulo - Brazil). 2003. Rós, N.; Coutinho-Camillo, C. C.; Melo, A. I.; da Silva, E. M.; Zeviani, M. H.; de Bessa Garcia, S. A.; Santos, P. C. C.; Nagai, M. A..
  20. Gene expression and estrogen receptor status in breast cancer. In: 1º Simpósio Avanços de Pesquisas Médicas dos Laboratórios de Investigação Médica. Poster presentation at 1º Simpósio Avanços de Pesquisas Médicas dos Laboratórios de Investigação Médica (São Paulo - Brazil). 2003. Nagai, M. A.; Rós, N.; de Bessa Garcia, S. A.; Neto, M. M.; Miracca, E. C.; Brentani, M. M.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2006/08/25 PAWR expression is down-regulated by 17B-estradiol and its increased expression is associated with breast cancer progression XXI Annual Meeting of the Federation of Experimental Biology Societies - FeSBE
Federação de Sociedades de Biologia Experimental (Águas de Lindóia, Brazil)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2012 - 2013 Sponsorship search, organization of participants' data, participant's support during the SPSAS – São Paulo School of Advanced Sciences. Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment. (2013/02/03 - 2013/02/08)
Meeting (Member of the Organising Committee)
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil

Event participation

Activity description
Type of event
Event name
Institution / Organization
2024/09/27 - 2024/09/27 The European Researchers Night initiatives have the objective of raise awareness among young people about the importance of research and innovation in Europe for a more sustainable and inclusive future, but also about the fact that scientific careers can be crucial in finding solutions that minimize society's problems. Nevertheless, the consortium's main objective is to give communities a voice and bring researchers and science closer to civil society. The idea is not just passive and unidirectional awareness
Exhibition
European Researchers Night 2024
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/04/05 - 2024/04/05 VIII Symposium of the Portuguese Glial Network was a day of seminars about the role of glial cells in the function of the nervous system, in health and disease conditions. In addition, we could have a good idea of the glial research not only in different laboratories from Portugal but also from another countries. The poster session allow us to find research related to our goals providing a very good interaction and contacts establishment.
Symposium
VIII Symposium of the Portuguese Glial Network
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2019 Attendance at Porto Cancer Meeting (The cancer ecosystem) & Porto-Bordeaux Join Meeting with poster presentation
Meeting
Porto Cancer Meeting (The cancer ecosystem) & Porto-Bordeaux Join Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2017 Presention title: PAR4 (Prostate Apoptosis Response 4) secretion in normal and tumoral breast cell lines maintained in hypoxia
Seminar
General Seminars of the Center for Translational Research in Oncology - CTO
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
2017 - 2017 Attendance at AACR International Conference on Translational Cancer Medicine with poster presentation (São Paulo - Brazil)
Meeting
AACR International Conference on Translational Cancer Medicine
2016 - 2016 Attendance at Innovation in Cancer Research seminar (São Paulo - Brazil)
Seminar
Innovation in Cancer Research
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
2015 - 2015 Presentation title: Modulation of Wnt pathway in MCF7 breast cancer cells with increased PAR4 expression before and after docetaxel treatment.
Seminar
General Seminars of the Center for Translational Research in Oncology - CTO
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
2015 - 2015 Attendance at 106th AACR Annual Meeting with poster presentation (Philadelphia - USA)
Meeting
106th AACR Annual Meeting
2014 - 2014 Attendance at the seminar: Cancer stem cells - origins, properties and consequences for therapy and Depression, stress and quality of life in cancer patients - is inflammation the link? (São Paulo - Brazil)
Seminar
Cancer stem cells - origins, properties and consequences for therapy and Depression, stress and quality of life in cancer patients - is inflammation the link? fo
2013 - 2013 Attendance at and organization support to SPSAS - São Paulo School of Advanced Sciences, Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment (São Paulo - Brazil) with poster presentation
Other
SPSAS - São Paulo School of Advanced Sciences, Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
2012 - 2012 Attendance at 58th Brazilian Congress on Genetics with poster presentation (Foz do Iguaçú - Brazil) 58th Brazilian Congress on Genetics
Brazilian Genetics Society, Brazil
2010 - 2010 Attendance at 4 Symposium Advances in Medical Research at Medical Research Laboratories at Hospital das Clínicas - FMUSP with poster presentation and other poster participation
Symposium
4 Symposium Advances in Medical Research at Medical Research Laboratories at Hospital das Clínicas - FMUSP
Universidade de São Paulo Hospital das Clínicas, Brazil
2009/08 - 2009/08 Attendance at 55th Brazilian Congress on Genetics with poster presentation and course participation (Proteomics: Fundamentals, Applications and Challenges, workload: 3h)
Congress
55th Brazilian Congress on Genetics
Brazilian Genetics Society, Brazil
2008 - 2008 Attendance at IV ENCIBio - Biosafety Commissions National Meeting (São Paulo - Brazil)
Meeting
IV ENCIBio - Biosafety Commissions National Meeting
2006 - 2006 Attendance at Symposium on Biosafety of Genetically Modified Organisms (São Paulo - Brazil)
Symposium
Symposium on Biosafety of Genetically Modified Organisms (GMOs)
2005 - 2005 Attendance at IV São Paulo Research Conference Cancer Today from Molecular Biology to Treatment with 1 poster presentation and other poster participation (São Paulo - Brazil). My poster presentation was awarded.
Conference
IV São Paulo Research Conference Cancer Today from Molecular Biology to Treatment
Universidade de São Paulo, Brazil
2005 - 2005 Attendance at 2 Symposium Advances in medical research from medical research laboratories - HC-FMUSP with poster presentation (São Paulo - Brazil)
Symposium
2 Symposium Advances in medical research from medical research laboratories - HC-FMUSP
Universidade de São Paulo Hospital das Clínicas, Brazil
2004/09 - 2004/09 Attendance at 50th Brazilian Congress on Genetics with poster presentation and course participation (From chromosomes to microgenomics for the cancer research, workload: 3 h)
Congress
50th Brazilian Congress on Genetics
Brazilian Genetics Society, Brazil
2003 - 2003 Attendance at 1 Symposium Advances in Medical Research of Medical Research Laboratories - HC-FMUSP with 1 poster presentation and 2 other posters participation (São Paulo - Brazil)
Symposium
1 Symposium Advances in Medical Research of Medical Research Laboratories - HC-FMUSP
Universidade de São Paulo Hospital das Clínicas, Brazil
2002 - 2002 Attendance at New Clinical and Molecular Approaches for Cancer Symposium (São Paulo - Brazil)
Symposium
New Clinical and Molecular Approaches for Cancer

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2016 - 2017 IV Course of Molecular Biology: from Theory to practice – Determining genic expression and genetic polymorphisms. I taught the theoretical and practical classes about cDNA synthesis. In addition, I worked in the course organization tasks. (Bachelor) Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
2015 - 2017 AKT pathway class in Theoretical course in Mastology for post-graduation students Theoretical course in Mastology (Especialização pós-bacharelato) Study Center - Prof. Dr. João Sampaio Góes Jr., Brazil

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2014 - 2016 Panel appraiser during the VI, VII and VIII graduate course in oncology of the Faculty of Medicine of University of São Paulo (FMUSP) and Cancer Institute of São Paulo (ICESP)
Evaluator
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil

Other jury / evaluation

Activity description Institution / Organization
2018 - Current Reviewer Board Member of Revista de Medicina - University of São Paulo, Brazil
2009 - 2016 I am part of the judging commission board for the selection of students for the Staff improvement program in oncogenes and tumor suppressor genes of the School of Permanent Education (EEP) of the Clinics Hospital (HC) of FMUSP Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
Distinctions

Other distinction

2005 Young Investigator Award for Excellence in Research
IV São Paulo Research Conference. Cancer Today: from Molecular Biology to Treatment, Brazil