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Henriqueta Louro is graduated in Biochemistry (Faculty of Sciences, Lisbon University), Ph.D in Public Health (ENSP, Nova University of Lisbon) and works since 1997 in the Department of Human Genetics of the National Institute of Health Dr. Ricardo Jorge. She is a researcher in the field of genetic toxicology and a specialist in Human Genetics (Ministry of Health, Portugal) and works as research scientist in the field of genetic toxicology, since 1997. She is involved in studies in human biomonitoring and nanotoxicology, with participation in European projects such as Nanogenotox, Nanoreg and HBM4EU, and responsible investigator in national projects. She is a task co-leader in the recently approved European Partnership for the Assessment of Risks from Chemicals (PARC; 2022-2029) and participates in ExpoAdvance- Development of a Roadmap for Action for Advancing Aggregate Exposure to Chemicals (EFSA) and in OECD project on Using Adverse Outcome Pathways (AOP) to address combined exposures to chemicals with relevant effect-biomarkers. Contributes to the European Food Safety Authority (EFSA) cross-cutting Working Groups on Genotoxicity, on Nanotechnologies and on NAMs, as well as for the working group on Toxicology of FEEDAP panel. In addition, is agGenotoxicity expert for Scientific Committee for Consumer Safety (SCCS) - WG on cosmetic ingredients. Recently, she started to contribute to IARC monographs working group.
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Identification

Personal identification

Full name
Maria Henriqueta Dias Lourenço Garcia Louro

Citation names

  • Louro, Henriqueta
  • Maria Henriqueta Louro

Author identifiers

Ciência ID
721D-2BB1-7DB1
ORCID iD
0000-0001-9744-7332
Google Scholar ID
https://scholar.google.com/citations?hl=pt-PT&user=90W_9aYAAAAJ
Researcher Id
P-1893-2019
Scopus Author Id
6507971479

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Genetics and Heredity
  • Natural sciences - Biological Sciences - Biochemistry
  • Engineering and Technology - Nano-technology - Nano-materials
  • Medical and Health Sciences - Health Sciences - Public and Environmental Health
  • Medical and Health Sciences - Health Sciences - Public and Environmental Health

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2014/05/06
Concluded
 Doutoramento em Saúde Pública, especialidade Saúde Ambiental e Ocupacional / PhD in Public Health - Environmental and Occupational Health (Doutoramento)
Universidade Nova de Lisboa Escola Nacional de Saúde Pública, Portugal
"Nanomateriais Manufaturados: Avaliação de segurança através da caracterização dos seus efeitos genéticos" (THESIS/DISSERTATION)
 Aprovado
2012
Concluded
 Curso Doutoral em Saúde Pública - Especialidade em Saúde Ambiental e Ocupacional / Doctoral Course on Public Helath - specialist in environmental and occupational health (Doutoramento)
Major in Saúde Ambiental e Ocupacional
Universidade Nova de Lisboa Escola Nacional de Saúde Pública, Portugal
"NANOMATERIAIS MANUFATURADOS: AVALIAÇÃO DE SEGURANÇA ATRAVÉS DA CARATERIZAÇÃO DOS SEUS EFEITOS GENÉTICOS " (THESIS/DISSERTATION)
 16
2004/09 - 2004/09
Concluded
 Certified researcher for animal science (FELASA, C level) (Outros)
Federation of European Laboratory Animal Science Associations, United Kingdom
 Aproved
2002 - 2003
Concluded
 Especialista em Genética Humana/ Specialist in Human Genetics (Título de especialista)
Ministério da Saúde, Portugal
1997
Concluded
 Bioquímica /Biochemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Avaliação de efeitos genotóxicos em ratinhos transgénicos contendo o gene LacZ" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2024/07/10 - Current Principal Investigator (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2015 - Current Researcher (Research) Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
2019/02/01 - 2024/06/30 Auxiliary Researcher (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
1997/09 - 2004/06 Researcher (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Other Careers

Category
Host institution 		Employer
2008 - 2020/01/31 Assistente Principal (Técnico Superior de Saúde - Genética) Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2004/07 - 2008/09 Assistente (Técnico Superior de Saúde - Genética) Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
Projects

Contract

Designation Funders
2015 - Current Toxomics- Centre for Toxicogenomics and Human Health
UID/BIM/00009/2013
Post-doc
Fundação para a Ciência e a Tecnologia
2022/05/01 - 2029/04/30 EU Partnership for the Assessment of Risks from Chemicals (PARC)
GA 101057014
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Horizon Europe
Ongoing
2022/05/01 - 2029 PARC- Partnership for the assessment of risks from Chemicals
101057014
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Horizon Europe Framework Programme (HORIZON)
Ongoing
2022/10/10 - 2026/04/30 Using Adverse Outcome Pathways (AOP) to address combined exposures with relevant effect biomarkers
Joint project of OECD’s Working Party on Hazard Assessment (WPHA) & Working Party on Exposure Assessment (WPEA)
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge
Ongoing
2023/05/01 - 2024/05/01 ExpoAdvance- Development of a Roadmap for Action for Advancing Aggregate Exposure to Chemicals
OC/EFSA/ED/2022/04
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
 European Food Safety Authority
Ongoing
2023/05 - 2024/05 ExpoAdvance- Development of a Roadmap for Action for Advancing Aggregate Exposure to Chemicals
OC/EFSA/ED/2022/04
 European Food Safety Authority
2018/10 - 2022/10 INGESTnano - Cellular and Molecular Mechanisms of Toxicity of Ingested Nanomaterials
PTDC/SAU-PUB/29481/2017
Principal investigator
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
 Fundação para a Ciência e a Tecnologia
2017/12/31 - 2022/06/30 HBM4EU - European Human Biomonitoring Initiative
GA 733032, 2017
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Concluded
2017 - 2022/06 European Human Biomonitoring Initiative (HBM4EU)
733032
Researcher
Horizon 2020 - Research and Innovation Framework Programme, Belgium
 European Commission
Ongoing
2018/10 - 2021/10 ToxApp4NanoCELFI - A predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibers in a co-culture system
PTDC/SAU-PUB/32587/2017
Researcher
Fundação para a Ciência e a Tecnologia
2019/01/01 - 2019/12/31 Centre for Toxicogenomics and Human Health
UID/BIM/00009/2019
Universidade Nova de Lisboa Medical School, Portugal

Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2016/08 NANoREG - A common European approach to the regulatory testing of nanomaterials
310584
Researcher
Research Executive Agency
2013 - 2015 Mycomix-Exploring the toxic effects of mixtures of mycotoxins in infant food and potential health impact
PTDC/DTP-FTO/0417/2012
Researcher
Fundação para a Ciência e Tecnologia
2011/01/01 - 2013/12/31 Projecto Estratégico - UI 9 - 2011-2012
PEst-OE/SAU/UI0009/2011
Universidade Nova de Lisboa Medical School, Portugal

Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2013 NANOGENOTOX – Safety Evaluation of Manufactured Nanomaterials by Characterization of their Potential Genotoxic Hazard
20092101
 European Commission
2010 - 2013 HERA - Environmental Risk Assessment of a contaminated estuarine environment: a case study
PTDC/SAU-ESA/100107/2008
Researcher
Fundação para a Ciência e Tecnologia
2008 - 2011 Environmental Tobacco smoke exposure at Portuguese restaurants, bars and nightclubs: health effects and early molecular mechanisms underlying respiratory disorders
FCG/ACSS
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
 Fundação Calouste Gulbenkian
Concluded
2008 - 2009 Environmental exposure to uranium mines and their residues. Influence of polymorphisms in DNA repair genes in the frequency of chromosomal aberrations and health implications
132/2007
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
 Ministério da Saúde
Concluded
2001 - 2006 Characterization of mutagenic effects of poly(ADP-ribose) polymerase deficiency in transgenic mice
POCTI/MGI/34270/2000
Researcher
Fundação para a Ciência e Tecnologia
Outputs

Publications

Book chapter
  1. Dora Rolo; Ana Tavares; Nádia Vital; Maria João Silva; Henriqueta Louro. "Overview of Adverse Outcome Pathways and Current Applications on Nanomaterials". 2022.
    10.1007/978-3-030-88071-2_17
  2. Nádia Vital; Mariana Pinhão; Naouale El Yamani; Elise Rundén-Pran; Henriqueta Louro; Maria Dušinská; Maria João Silva. "Hazard Assessment of Benchmark Metal-Based Nanomaterials Through a Set of In Vitro Genotoxicity Assays". 2022.
    10.1007/978-3-030-88071-2_14
  3. Nádia Vital; Mariana Pinhão; Naouale El Yamani; Elise Rundén-Pran; Henriqueta Louro; Maria Dušinská; Maria João Silva. "Correction to: Hazard Assessment of Benchmark Metal-Based Nanomaterials Through a Set of In Vitro Genotoxicity Assays". 2022.
    10.1007/978-3-030-88071-2_18
  4. Adriana Vieira; Ana Gramacho; Dora Rolo; Nádia Vital; Maria João Silva; Henriqueta Louro. "Cellular and molecular mechanisms of toxicity of ingested nanomaterials". Switzerland: Springer Nature Switzerland AG, 2022.
  5. Rolo, Dora; Ana Tavares; Vital, Nádia; Maria João Silva; Louro, Henriqueta. "Chapter 17: Overview of Adverse Outcome Pathways and current applications on nanomaterials". In Nanotoxicology in safety assessment of nanomaterials.. Switzerland: Springer Nature Switzerland AG, 2022.
    In press
  6. Adriana Vieira; Ana Gramacho; Dora Rolo; Nádia Vital; Maria João Silva; Henriqueta Louro. "Cellular and Molecular Mechanisms of Toxicity of Ingested Titanium Dioxide Nanomaterials". 2022.
    10.1007/978-3-030-88071-2_10
  7. Louro, Henriqueta. "Relevance of Physicochemical Characterization of Nanomaterials for Understanding Nano-cellular Interactions". Switzerland: Springer, 2018.
    https://doi.org/10.1007/978-3-319-72041-8_8
  8. Louro, Henriqueta; Bettencourt, Ana; Gonçalves, Lídia M.; Almeida, António J.; Silva, Maria João; Louro, Henriqueta. "Role of nanogenotoxicology studies in safety evaluation of nanomaterials". In Nanotechnology applications in tissue engineering, edited by Sabu Thomas,Yves Grohens, Neethu Ninan, 263-287. Portugal: Elsevier, 2015.
    Published • 10.1016/B978-0-323-32889-0.00016-9
  9. Louro, Henriqueta; Pinto, Miguel; Vital, Nádia; Tavares, Ana; Costa, Pedro M.; Silva, Maria João. "The LacZ plasmid-based transgenic mouse model: an integrative approach to study the genotoxicity of nanomaterials". In Genotoxicity and DNA Repair: A Practical Approach, Methods in Pharmacology and Toxicology, edited by L. María Sierra and Isabel Gaivão. Portugal: Springer/ Humana Press, 2014.
    Published • 10.1007/978-1-4939-1068-7_2
  10. Urbano, Kevin V.; Louro, Henriqueta; Silva, Maria João. "Cost/Benefit of Mutation Induction under PARP1 Deficiency: From Genomic Instability to Therapy". In Advances in Genetics Research. Portugal: Nova Science Publishers, Inc., 2011.
    Published
  11. Louro, Henriqueta. "In vivo mutagenic effects of alkylating agents eliciting different DNA-adducts". 2010.
Conference abstract
  1. Barros, Patrícia; Amaral, Andreia J.; Abrantes, Leonor B.; Oliveira, Tiago; Louro, Henriqueta; Silva, Maria J.; Jordan, Peter; Gama-Carvalho, Margarida; Matos, Paulo. "76P Stimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via the BCL6/STAT5-switch". 2017.
    Published • 10.1093/annonc/mdx361.069
Conference paper
  1. Vital, Nádia; Silva, Maria João; Kranendonk, M.; Louro, Henriqueta. "In Vitro Cytotoxicity and Genotoxicity Assessment of Novel Cellulose Nanomaterials using intestinal cells". 2023.
  2. Vital, Nádia; Silva, Maria João; Louro, Henriqueta. "Investigating ingested nanomaterials’ safety – the case of TiO2 and innovative nanocelluloses.". 2023.
  3. Vital, Nádia; Silva, Maria João; Kranendonk, Michel; Louro, Henriqueta. "Investigation of In Vitro Cytotoxicity and Genotoxicity of Novel Cellulose Nanomaterials in two intestinal cell models". 2023.
  4. Louro, Henriqueta. "Nanotoxicologia e Nanosegurança". 2023.
  5. Louro, Henriqueta. "The establishing of the program the human biomonitoring in the European Union - the portuguese perspetive". 2023.
  6. Jones, Kate; Galea, K.S.; Scholten, B.; Loikala, M.; Porras, S.P.; Bousoumah, R.; Ndaw, S.; et al. "HBM4EU diisocyanates study – results from a collaborative European human biological monitoring study on occupational exposure". 2023.
  7. Louro, Henriqueta. "Aplicação de biomarcadores de efeito na biomonitorização humana: teste do cometa e teste do micronúcleo". 2023.
  8. Dietrich, Jessica; Marko, Doris; Behr, Anne-Cathrin; Driven, Hubert; Silva, Maria João; Louro, Henriqueta; PARC 5.1.1.a Project Team. "Hazard characterisation of the mycotoxins enniatins and Alternaria toxins to close data gaps and improve risk assessment for human health". 2023.
  9. Zare Jeddi, Maryam; Hopf, N.; Louro, Henriqueta; Silva, Maria João; Costa, Carla; Viegas, S.; Scheepers, P.; et al. "Unlocking the Potential of Environmental and Health Research with FAIREHR". 2023.
  10. Aimonen, K.; Silva, Maria João; Tavares, Ana; Moreira, Rodrigo; Louro, Henriqueta; Catalán, J.; Duca, R.; et al. "Genotoxicity in peripheral blood leukocytes and reticulocytes of e-waste management workers". 2023.
  11. Vital, Nádia; Ventura, Célia; Kranendonk, M.; Silva, Maria João; Louro, Henriqueta. "Global DNA methylation and Reactive Oxygen Species assessment after in vitro exposure to novel cellulose nanomaterials on intestinal cells". 2023.
  12. Vital, Nádia; Silva, Maria João; Kranendonk, M.; Louro, Henriqueta. "Avaliação da Segurança de Nanomateriais de Celulose Inovadores". 2023.
  13. Aiello Holden, Kiara; Tait, Sabrina; Viguié, Catherine; Mhaouty-Kodja, Sakina; Corsini, Emanuela; Silva, Maria João; Zalko, Daniel; et al. "Hazard assessment of bisphenol A alternatives to close data gaps of concern for human health and improve their risk assessment". 2023.
  14. Zare Jeddi, Maryam; Conrad, A.; Kolossa-Gehring, M.; Hopf, N.; Viegas, S.; Pasanen-Kase, R.; Sepai, O.; et al. "A roadmap for a 21st century human biomonitoring toolbox". 2023.
  15. Scheepers, Paul; Viegas, S.; Duca, R.C.; Cseresznye, A; Cleys, P.; Covaci, A.; Goën, T.; et al. "The HBM4EU e-waste study: exploratory survey of worker’s exposure to toxic contaminants". 2023.
  16. Valente, Ana; Vieira, Luís; Silva, Catarina; Louro, Henriqueta; Silva, Maria João; Ventura, Célia. "Effects of TiO2 Nanoparticles on the Genome-Wide Methylation of Human Epithelial Intestinal Cells". 2023.
  17. Silva, Maria João; Louro, Henriqueta. "Construction of PARC’s indicator framework: design of outcome and impact indicators". 2023.
  18. Santonen, Tiina; Louro, Henriqueta; Bocca, Beatrice; Bousoumah, Radia; Corneliu Duca, Radu; Fucic, Aleksandra; Galea, Karen S.; et al. "How can multi-national occupational studies support policy making in Europe? Experiences from HBM4EU and PARC occupational studies". 2023.
  19. Silva, Maria João; Aimonen, K.; Louro, Henriqueta; Tavares, A.; Moreira, R.; Catalan, J.; Duca, R.C.; et al. "Effect biomarkers in e-waste management workers". 2023.
  20. Rolo, Dora; Pereira, Joana F.S; Vieira, Adriana; Roque, Rossana; Gramacho, Ana Catarina; Vital, Nádia; Matos, Paulo; et al. "Cellular, Molecular and Genotoxic Effects of Digested Titanium Dioxide Nanomaterials". 2022.
  21. Rolo, Dora; Vital, Nádia; Silva, Maria Raquel; Louro, Henriqueta. "Oral Exposure to TiO2 and Cellulose Nanomaterials: review of hazard identification in the adverse outcome pathway landscape". 2022.
  22. Vital, Nádia; Pinto, Fátima; Kranendonk, Michel; Silva, Maria João; Louro, Henriqueta. "Analysis of the in vitro cytotoxicity and genotoxicity of cellulose nanomaterials in intestinal cells". 2022.
  23. Santonen, Tiina; Bocca, Beatrice; Bousoumah, Radia; Duca, Radu Corneliu; Galea, Karen S.; Godderis, Lode; Göen, Thomas; et al. "Assessment of occupational exposure to hexavalent chromium – recommendations from HBM4EU chromate study". 2022.
  24. Ventura, Célia; Vieira, Luís; Silva, Catarina; Louro, Henriqueta; Silva, Maria João. "Differentially expressed microRNAs in human bronchial epithelial cells after exposure to nanofibrillar, microfibrillar or nanocrystalline cellulose". 2022.
  25. Ventura, Célia; Pinto, Fátima; Vieira, Luís; Louro, Henriqueta; Silva, Maria João. "Occupational exposure to emerging cellulose nanomaterials and potential respiratory effects: uncovering exposure-effect relationships using in vitro systems". 2022.
  26. Pinto, Fátima; Ventura, Célia; Cadete, João; Lourenço, Ana Filipa; Pedrosa, Jorge F.S.; Vital, Nádia; Pereira, Joana F.S.; et al. "Investigation of potential respiratory adverse effects of micro/nanofibrillated cellulose and cellulose nanocrystals using human lung cell lines.". 2022.
  27. Ventura, Célia; Marques, Catarina; Cadete, João; Vilar, Madalena; Pedrosa, J.F.S.; Pinto, P.; Rosa, R.R.; et al. "Cyto-genotoxic effects of distinct micro/nanocelluloses in human osteoblastic and mice fibroblastic cells". 2022.
  28. Vieira, A.; Vital, N.; Roque, R.; Gramacho, A.C.; Rolo, D.; Gonçalves, L.D., ; Bettencourt, A.; et al. "Ingested nanomaterials: impact of digestion process in the physicochemical characteristics and biological consequences in intestinal cells.". 2021.
  29. Vital N; Pinto F; Rolo D; Pedrosa J; Ferreira PJT ; Kranendonk M; Silva MJ; Louro H.. "Cytotoxicity Assessment of Novel Cellulose Nanomaterials on Intestinal Cells". Paper presented in 4Th International Conference on Food Contaminants (ICFC2021), Lisbon, 2021.
    Published
  30. A. M. Tavares; I. Alves; R. Moreira; H. Louro; C. Ladeira; S. Viegas; S. Loureiro; et al. "Occupational exposure to metals and PAHs: combining literature-based exposure and in vitro hazard data towards a mixture risk assessment". 2021.
    Published
  31. Rolo, D; Pereira JFS; Matos P ; Gonçalves L; Bettencourt AF; Jordan P; Silva MJ; Louro H.. "Titanium Dioxide Nanoparticles molecular effects: Internalization in the Human Intestinal Epithelium. EMGS 2021 - Environmental Mutagenesis & Genomics Society Virtual Annual Meeting. 22-29 September 2021. Environmental and Molecular Mutagenesis S1, 42.". Online, 2021.
    Published
  32. Sónia Namorado; Andromachi Katsonouri; Hans Reynders; Maja Mampaey; Elena Tarroja; Robert Barouki; Henriqueta Louro; et al. "The value of Human Biomonitoring to assess chemical exposure and support policies: perceptions of the European population.". Nova Iorque, 2021.
  33. Silva, Maria João; Alvito, Paula; Louro, Henriqueta. "Contribution to micro- and nanoplastics hazard assessment: the lessons learnt from nanomaterials toxicity assessment". Paper presented in EFSA Scientific Colloquium N°25: a coordinated approach to assess human health risks of micro- and nanoplastics in food, Online, 2021.
  34. Henriqueta Louro; Célia Ventura; Dora Rolo; Nádia Vital; Fátima Pinto; Maria João Silva. "Early-stage nanosafety assessment as a critical tool for innovative nanomaterials development.". Online, 2021.
  35. D Rolo; JFS Pereira; P Matos; L Gonçalves; AF Bettencourt; P Jordan, ; MJ Silva; H Louro. "Cellular effects of Titanium Dioxide Nanoparticles in the intestine". Online, 2021.
    Published
  36. Fátima Pinto; Célia Ventura,; Ana Filipa Lourenço; Paulo J.T. Ferreira; Henriqueta Louro; Maria João Silva. "Evaluation of cytotoxic and genotoxic effects of functionalized nanocellulose in a co-culture system approaching the lung environment.". Paper presented in NANOTOX 2021- 10th International Conference on Nanotoxicology, virtual meeting, Online, 2021.
    Published
  37. Tavares, Ana Maria; Alves, Inês; Moreira, Rodrigo; Louro, Henriqueta; Ladeira, Carina; Viegas, Susana; Loureiro, Susana; et al. "Occupational exposure to metals and PAHs: combining literature-based exposure and in vitro hazard data towards a mixture risk assessment a mixture risk assessment". 2021.
  38. Vieira, Adriana; Rolo, Dora; Vital, Nádia; Martins, Carla; Assunção, Ricardo; Alvito, Paula; Gonçalves, Lídia; et al. "Titanium dioxide nanomaterials - induced DNA damage in intestinal cells following simulated in vitro digestion". 2021.
  39. Ventura, Célia; Vieira, Luís; Louro, Henriqueta; Silva, Maria João. "Changes in the human genome and epigenome induced by nanomaterials". 2021.
  40. Pinto, Fátima; Ventura, Célia; Teixeira, Sara; Lourenço, Ana Filipa; Fernandes, S.N.; da Rosa, R.R.; Godinho, M.H.; et al. "Exploring potential genotoxic effects of nanocelluloses versus multi-walled carbon nanotubes in co-cultures of human lung epithelial cells and monocyte-derived macrophages". 2021.
  41. Ventura, Célia; Teixeira, Sara; Marques, Catarina; Vilar, Madalena; Pinto, Fátima; Lourenço, A.F.; Sousa Mendes, A.; et al. "The use of the in vitro micronucleus assay on the genotoxicity assessment of cellulose nanofibrils in mammalian cell lines". 2020.
  42. Louro, Henriqueta; Vieira, Adriana; Gramacho, Ana Catarina; Rolo, Dora; Vital, Nádia; Martins, Carla; Assunção, Ricardo; et al. "Analysis Of The Cytotoxicity And Genotoxicity of Digested Titanium Dioxide Nanomaterials (TiO2) In Intestinal Cells". 2020.
  43. Rolo, Dora; Pereira, Joana F.S.; Matos, Paulo; Vieira, Adriana; Vital, Nádia; Jordan, Peter; Silva, Maria João; Louro, Henriqueta. "Validation of Caco-2/HT29-MTX model to assess the potential risk of ingested titanium dioxide nanoparticles". 2020.
  44. Louro, Henriqueta; Silva, Maria João. "The need for early-stage safety assessment in the development of nanomaterials – the role of nanotoxicology". 2020.
  45. Alves, Inês; Ladeira, Carina; Tavares, Ana M.; Viegas, Susana; Louro, Henriqueta; Silva, Maria João. "In vitro combined toxicity of chromium, nickel and PAHS in human lung cells as support for mixtures risk assessment". 2020.
  46. Tavares, Ana Maria; Viegas, Susana; Louro, Henriqueta; Silva, Maria João. "Risk assessment of combined occupational exposure to hexavalent chromium, nickel, and PAHs: a literature-based approach". 2020.
  47. Pinto, Fátima; Ventura, Célia; Teixeira, Sara; Vilar, Madalena; Lourenço, Ana Filipa; Ferreira, Paulo J.T.; Louro, Henriqueta; Silva, Maria João. "Study on cellulose nanofibrils biological effects in different cellular models". 2020.
  48. Alvito, Paula; Vasco, Elsa; Assunção, Ricardo; Louro, Henriqueta; Namorado, Sónia; Viegas, S.; Silva, MJ. "One Health Day, Emerging Diseases - Mycotoxins under the Human Biomonitoting Initiative (HBM4EU): challenges in the near future: Book of abstracts". 2020.
  49. Rolo, Dora; Assunção, Ricardo; Silva, Maria João; Louro, Henriqueta. "Systematic Literature Reviews as a tool to develop Adverse Outcome Pathway landscapes in Nanotoxicology: case study of ingested Titanium dioxide nanomaterials". 2020.
    10.3390/IOCN2020-08533
  50. Louro, Henriqueta; Rolo, Dora; Gramacho, Ana C.; Pereira, Joana; Matos, Paulo; Jordan, Peter; Martins, Carla; et al. "Nano-bio interactions of titanium dioxide nanomaterials in the intestinal moiety after simulated digestion in vitro". 2020.
  51. Santonen, Tiina; Alimonti, A.; Bocca, B.; Duca, R.C.; Galea, K.S.; Godderis, L.; Göen, T.; et al. "Human biomonitoring in occupational setting – Cr VI". 2020.
  52. Louro, Henriqueta. "Human Biomonitoring (HBM) in risk assessment". 2019.
  53. Louro, Henriqueta; Ventura, Célia; Silva, Maria João. "Nanotoxicology research at INSA – do NMs contribute for genotoxic effects that may lead to cancer?". 2019.
  54. Gramacho, Ana Catarina; Silva, Maria João; Louro, Henriqueta. "Ingested nanomaterials: effects of titanium dioxide in human cells". 2019.
  55. Gomes, Bruno Costa; Louro, Henriqueta; Huuskonen, Pasi; Santonen, Tiina; Huumonen, Katriina; Ndaw, Sophie; Fernández, Mariana F.; Silva, Maria João. "The use of effect biomarkers in human biomonitoring studies: exposure to hexavalent chromium". 2019.
  56. Vasconcelos, Ana Luísa; Silva, Maria João; Louro, Henriqueta. "Contribution to hazard characterization of the Next-Generation Plasticizer DINCH®: cytotoxicity and genotoxicity assessment in human cells". 2019.
  57. Silva, Maria João; Louro, Henriqueta; Ventura, Célia; Gonçalves, João. "Environmental and Genetic Determinants of Human Disease: an overview of current research and the way forward". 2019.
  58. Afonso, Catarina; Gomes, Bruno Costa; Louro, Henriqueta; Nogueira, Ana; Pinhal, Hermínia; Reis, S.; Ventura, Célia; et al. "The Usefulness of Early Effect Biomarkers in Monitoring Occupational Exposure to Hexavalent Chromium". 2019.
  59. Bischoff, Nicolaij; Mota, J.; Louro, Henriqueta; Ventura, Célia; Ferreira, J.R.B.; Lima, A,; Silva, Maria João. "Safety assessment of a new matrix metalloproteinase inhibitor extracted from Lupinus albus seeds, through the analysis of its cytotoxic and genotoxic properties". 2019.
  60. Afonso, Catarina; Gomes, Bruno Costa; Louro, Henriqueta; Nogueira, Ana; Pinhal, Hermínia; Reis, Susana; Ventura, Célia; et al. "Occupational exposure to hexavalent chromium: biomarkers of genotoxicity in human peripheral blood". 2019.
  61. Afonso, Catarina; Gomes, Bruno Costa; Louro, Henriqueta; Ladeira, Carina; Pinhal, Hermínia; Nogueira, Ana; Santos, Sílvia; et al. "Occupational exposure to Hexavalent chromium: the portuguese case within the collaborative european human biological monitoring study". 2019.
  62. Teixeira, Sara; Lourenço, Ana Filipa; Ventura, Célia; Louro, Henriqueta; Ferreira, Paulo; Silva, Maria João. "Exploring the toxicity of cellulose nanofibrils in a lung epithelial cell line". 2019.
  63. Gramacho, Ana Catarina; Martins, Carla; Assunção, Ricardo; Gonçalves, Lídia; Simão Bettencourt, Ana; Paula, Alvito; Silva, Maria João; Louro, Henriqueta. "Evaluation of the cytotoxicity and genotoxicity of ingested titanium dioxide nanomaterials in intestinal cells". 2019.
  64. Vasconcelos, Ana Luisa; Silva, Maria João; Louro, Henriqueta. "Impact of DINCH® in human cells: evaluation of its potential cytotoxic and genotoxic effects". 2018.
  65. Vilar, Madalena; Lourenço, Ana Filipa; Ventura, Célia; Louro, Henriqueta; Ferreira, Paulo; Félix, Sérgio; Silva, Maria João. "Are cellulose nanofibrils safe for biomedical applications?". 2018.
  66. Louro, Henriqueta; Vasconcelos, Ana Luisa; Penque, Deborah; Silva, Maria João. "Human biomonitoring studies contribution for better public health decisions". 2018.
  67. Pinhão, Mariana; Loureiro, Susana; Louro, Henriqueta; Alvito, Paula; Silva, Maria João. "Mixtures health effects: mycotoxins in food". 2018.
  68. Barros, Patricia; Amaral, Andreia; Abrantes, Leonor; Oliveira, Tiago; Louro, Henriqueta; Silva, Maria Joâo; Jordan, Peter; Gama Carvalho, Margarida; Matos, Paulo. "Upregulation of RAC1/PAK1 signalling promotes DNA damage repair in colorectal cancer cells". 2018.
  69. Dias, Kamila; Louro, Henriqueta; Gonçalves, Lídia; Bettencourt, Ana; Silva, Maria João. "Assessing the Safety of Polymeric Nanoparticulated Systems developed for Drug Delivery with Human Osteoblasts". 2018.
  70. Vasconcelos, Luisa; Silva, Maria João; Louro, Henriqueta; Vasconcelos, Ana Luísa. "In vitro exposure to the next-generation plasticizer DINCH: cytotoxicity and genotoxicity assessment in human cells". 2018.
  71. Gomes, Bruno; Louro, Henriqueta; Silva, Maria João. "The relevance of effect biomarkers in human biomonitoring". 2018.
  72. Vital, Nádia; El Yamani, Naouale; Pinhão, Mariana; Rúden-Pra, Elise; Louro, Henriqueta; Dušinská, Maria; Silva, Maria João. "Contribution to the hazard assessment of benchmark metallic nanomaterials through a set of in vitro genotoxicity assays". 2018.
  73. Silva, Maria João; Louro, Henriqueta. "Can human biomonitoring studies contribute to improve public health decisions?". 2017.
  74. Pinhão, Mariana; Louro, Henriqueta; Silva, Maria João. "Evaluating the cytotoxic potential of a panel of manufactured nanomaterials using the plating efficiency assay". 2017.
    10.4172/2161-0495-C1-025
  75. Saruga, Andreia; Louro, Henriqueta; Santos, Joana; Silva, Maria João. "Hazard assessement of metallic nanomaterials in human respiratory cells". 2017.
  76. Louro, Henriqueta; Pinhão, Mariana; Santos, Joana; Silva, Maria João. "Connecting the cytotoxic and genotoxic effects of multi-walled carbon nanotubes to their physicochemical properties". 2017.
    10.4172/2161-0495-C1-024-005
  77. Saruga, Andreia; Louro, Henriqueta; Pinhão, Mariana; Silva, Maria João. "Hazard assessment of benchmark metallic nanomaterials in alveolar epithelial cells". 2017.
  78. Louro, Henriqueta; Monteiro-Gil, Octávia; Penque, Deborah; Silva, Maria João. "Evalution of a challenge assay as na effect biomarker in environmental or occupational biomonitoring studies". 2017.
  79. Dias, Kamila; Louro, Henriqueta; Gonçalves, Lídia; Bettencourt, Ana; Silva, Maria João. "Safety evaluation of novel polymeric nanocarriers for drug delivery using human osteoblasts". 2017.
  80. Dias, Kamila; Louro, Henriqueta; Gonçalves, Lídia; Silva, Maria João; Bettencourt, Ana. "Biocompatibility Assessment of Polymeric Nanoparticle Carriers for Drug Delivery in Human Osteoblasts". 2017.
  81. Louro, Henriqueta; Saruga, Andreia; Pinhão, Mariana; Santos, Joana; Silva, Maria João. "Tackling the uncertainties of emergent nanomaterials for public health: are metal nanoparticles hazardous pollutants?". 2017.
  82. Silva, Maria João; Ventura, Célia; Dias, Kamila; Saruga, Andreia; Pinhão, Mariana; Louro, Henriqueta. "Nanotoxicology and nanotechnology interplay towards a safe and responsible innovation". 2017.
  83. Barros, Patrícia; Amaral, Andreia; Abrantes, Leonor; Oliveira, Tiago; Louro, Henriqueta; Silva, Maria João; Jordan, Peter; et al. "Stimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via the BCL6/STAT5-switch". 2017.
  84. Pinto, Miguel; Sacadura, Joana; Louro, Henriqueta; Costa, Pedro Manuel; Lavinha, João; Costa, Maria Helena; Caeiro, Sandra; Silva, Maria João. "Toxicity of environmental pollutants: from the bench research to human biomonitoring studies". 2017.
  85. Santonen, T.; Alvito, Paula; Bessems, J.; Borges, T.; Brunet, D.; Buekers, J.; Cornelis, C.; et al. "Improving risk assessment of chemicals by the use of human biomonitoring - HBM4EU project activities". 2017.
  86. Saruga, Andreia; Louro, Henriqueta; Silva, Maria João. "Cyto- and Genotoxicity assessment of manufactured nano cerium dioxide in the A549 cell line". 2016.
  87. Silva, M.J.; Vital, Nádia; Pacheco, Solange; Antunes, Susana; Neves, Sofia; Louro, Henriqueta; Torre, Vukosava M.; et al. "Occupational exposure to environmental tobacco smoke in hospitality venues: are genetic- or proteomics-based biomarkers predictive of respiratory diseases?". 2016.
  88. Silva, Maria João; Pinto, Miguel; Costa, Pedro M.; Louro, Henriqueta; Castanheira, Isabel; Machado, Ausenda; Dias, Carlos; et al. "Environmental exposure to toxicants mixtures from a multi-purpose estuary: perspectives for a biomonitoring study in Portugal". 2016.
  89. Borges, Teresa; Silva, Maria João; Louro, Henriqueta. "Moving towards a safe-by-design approach for ENM: linking relevant properties to safety". 2015.
  90. Louro, Henriqueta; Tavares, Ana; Pinhão, Mariana; Silva, Maria João. "Exploring the correlation between physicochemical properties of nanomaterials and their genotoxic effects in human cells". 2015.
  91. Vital, Nádia; Louro, Henriqueta; Tavares, Ana; Silva, Maria João. "O ensaio do cometa: exemplo de aplicações na identificação de agentes genotóxicos e em estudos de biomonitorização humana". 2015.
  92. Pinto, Miguel; Louro, Henriqueta; Sacadura, Joana; Costa, Pedro M.; Caeiro, Sandra; Silva, Maria João. "Integrated investigation of the genotoxicity of a contaminated estuary sediment extract using LacZ plasmid-based transgenic mice". 2015.
  93. Silva, Maria João; Louro, Henriqueta; Borges, Teresa; Lavinha, João; Albuquerque, José Maria. "Contribution to nanomaterials safety assessment: the need of integrating in vitro, in vivo and in silico strategies". 2015.
  94. Tavares, Ana; Pinhão, Mariana; Mendonça, Inês; Louro, Henriqueta; Loureiro, Susana; Alvito, Paula; Silva, Maria João. "A contribution to hazard assessment of combined exposure to mycotoxins using in vitro toxicity testing". 2015.
    10.1016/j.toxlet.2015.08.1007
  95. Bettencourt, Ana; Graça, DIogo; Matos, A.; Ferreira, I.; Almeida, A.; Gonçalves, L.; Santos, Joana; Louro, Henriqueta; Silva, Maria João. "Safety assessment of poly(methylmethacrylate) nanomaterials for drug delivery: genotoxicity in mammalian cells". 2015.
  96. Bettencourt, A.; Graça, D.F.; Ferreira, IFS; Matos, A.; Louro, Henriqueta; Silva, Maria João; Almeida, A.J.; Gonçalves, L.M.. "Does surface charge play a role in nanoparticulate-systems toxicity?". 2015.
  97. Alvito, Paula; Assunção, Ricardo; Borges, T.; Leal, S.; Loureiro, S.; Louro, Henriqueta; Nunes, Baltazar; et al. "Risk assessment of multiple mycotoxins in infant food consumed by Portuguese children – the contribute of the MYCOMIX project". 2015.
    10.1016/j.toxlet.2015.08.377
  98. Silva, Maria João; Louro, Henriqueta; Lavinha, João. "Genotoxicity testing towards a knowledge-based regulation of nanomaterials". 2014.
  99. Louro, Henriqueta; Vital, Nádia; Pinhão, Mariana; Tavares, Ana; Lavinha, João; Silva, Maria João. "Study of the genotoxicity of multi-walled carbon nanotubes in human cell lines from the airway epithelia: implications for the regulatory testing of nanomaterials". 2014.
  100. Louro, Henriqueta; Pinhão, Mariana; Tavares, Ana; Vital, Nádia; Borges, Teresa; Gouveia, Helena; Silva, Maria João. "Is there a link between the physicochemical characteristics of multiwalled carbon nanotubes and their genotoxicity in human cells?". 2014.
  101. Louro, Henriqueta; Tavares, Ana; Vital, Nádia; Antunes, Susana; Costa, Pedro; Alverca, Elsa; Lavinha, João; Silva, Maria João. "Are standard genotoxicity tests useful for the safety evaluation of nanomaterials?". 2014.
  102. Louro, Henriqueta; Tavares, Ana; Vital, Nádia; Costa, Pedro; Alverca, Elsa; Zwart, Edwin; de Jong, Wim H.; et al. "Investigation of the in vivo genotoxic effects of a titanium dioxide nanomaterial in LacZ plasmid-based transgenic mice". 2014.
  103. Alvito, Paula; Assunção, Ricardo; Borges, T.; Leal, Sónia; Louro, Henriqueta; Martins, Carla; Martins, Vitor; et al. "MycoMix - Misturas de Micotoxinas em alimentos para crianças e potencial impacto na saúde". 2014.
  104. Louro, Henriqueta; Tavares, Ana; Silva, Maria João. "Nanomaterials safety investigation: analysis of genotoxic effects in a human bronchial epithelial cell line". 2013.
  105. Louro, Henriqueta; Tavares, Ana; Vital, Nádia; Lavinha, João; Silva, Maria João. "Estudo do efeito mutagénico de um nanomaterial de dióxido de titânio num modelo de ratinho transgénico". 2013.
  106. Tavares, Ana; Louro, Henriqueta; Vital, Nádia; Antunes, Susana; Lavinha, João; Silva, Maria João. "Caracterização da genotoxicidade de nanomateriais manufaturados numa linha celular de epitélio brônquico humano". 2013.
  107. Tavares, Ana; Louro, Henriqueta; Vital, Nádia; Antunes, Susana; Lavinha, João; Silva, Maria João. "Assessment of the genotoxicity of a titanium dioxide nanomaterial using a combination of in vitro and in vivo assays". 2013.
  108. Silva, Maria João; Dias, Anabela; Monteiro-Gil, Octávia; Louro, Henriqueta; Boavida, Guida. "Exposição Humana a radiação Ionizante: Efeitos Biológicos e Impacto na Saúde". 2013.
  109. Louro, Henriqueta; Tavares, Ana; Vital, Nádia; Antunes, Susana; Lavinha, João; Silva, Maria João. "Implicações das nanotecnologias para a saúde pública: avaliação da segurança dos nanomateriais". 2013.
  110. Pinto, Miguel; Sacadura, Joana; Louro, Henriqueta; Costa, Pedro Manuel; Lavinha, João; Silva, Maria João. "DNA and Chromosome Damaging Effects in Mice Exposed to an Estuary Sediment Extract". 2013.
  111. Pinto, Miguel; Louro, Henriqueta; Costa, Pedro Manuel; Caeiro, Sandra; SIlva, Maria João. "Can Estuary Sediment Contaminants Interfere with the DNA Repair Capacity of HEPG2 Cells?". 2013.
  112. Vital, Nádia; Louro, Henriqueta; Antunes, Susana; Penque, Deborah; Simões, Tânia; Silva, Maria João. "Biomonitoring the genetic effects of environmental tobacco smoke exposure in restaurant workers". 2013.
  113. Silva, Maria João; Tavares, Ana; Antunes, Susana; Lavinha, João; Louro, Henriqueta. "Safety evaluation of manufactured nanomaterials: comparison of genotoxic effects of multi-walled carbon nanotubes in two human cell lines". 2013.
  114. Pinto, Miguel; Sacadura, Joana; Louro, Henriqueta; Costa, Pedro Manuel; Costa, Maria Helena; Caeiro, Sandra; Lavinha, João; Silva, Maria João. "Genotoxicity and oxidative stress induced by sediments from the Sado Estuary and potential antimutagenic effects of quercetin". 2013.
  115. Pinto, Miguel; Louro, Henriqueta; Costa, Pedro Manuel; Costa, Maria Helena; Caeiro, Sandra; Lavinha, João; Silva, Maria João. "Cytotoxic and genotoxic potential of sediments from the Portuguese Mira-River Estuary". 2013.
  116. Pinto, Miguel; Louro, Henriqueta; Caeiro, Sandra; Costa, Pedro; Costa, Maria Helena; Lavinha, João; Silva, Maria João. "Avaliação do risco ambiental e para a saúde pública de um ambiente estuarino contaminado". 2013.
  117. Vicente, Ana Margarida; Sacadura, Joana; Pinto, Miguel; Louro, Henriqueta; Costa, Pedro Manuel; Lavinha, João; Caeiro, Sandra; Silva, Maria João. "Evaluation of Genotoxicity of Sediments from the Sado-River Estuary Using Solvent Extractions of Diferent Polarities". 2013.
  118. Louro, Henriqueta; Tavares, Ana; Antunes, Susana; Vicente, Ana Margarida; Silva, Maria João. "Nanomateriais Manufaturados- avaliação de efeitos genotóxicos e implicações para saúde pública". 2012.
  119. Louro, Henriqueta; Tavares, Ana; Antunes, Susana; Vicente, Ana; Silva, Maria João. "Different genotoxic effects of multi-walled carbon nanotubes in A549 cells: implications for nanomaterials safety investigation". 2012.
  120. Tavares, Ana; Alvito, Paula; Loureiro, Susana; Louro, Henriqueta; Silva, Maria João. "Aflatoxins and ochratoxin A in baby foods and analysis of interactive cyto- and genotoxic effects in a human intestinal cell line". 2012.
  121. Tavares, Ana; Louro, Henriqueta; Antunes, Susana; Quarré, Stéphanie; Simar, Sophie; Nesslany, Fabrice; Silva, Maria João. "Genotoxicity evaluation of three classes of manufactured nanomaterials on primary human lymphocytes". 2012.
  122. Pinto, Miguel; Louro, Henriqueta; Costa, Pedro; Costa, Maria Helena; Caeiro, Sandra; Lavinha, João; Silva, Maria João. "Characterization of cytotoxic and genotoxic effects of contaminated sediments from the Sado Estuary and potential human health risk". 2012.
  123. Silva, Maria João; Louro, Henriqueta; Lavinha, João. "Avaliação da segurança de nanomateriais manufacturados através da caracterização do seu potencial efeito genotóxico". 2011.
  124. Dias, Elsa; Louro, Henriqueta; Pereira, Paulo; Silva, Maria João. "Genotoxicidade da MCLR em vários modelos biológicos: linhas celulares, eritrócitos de murganho e linfócitos humanos". 2011.
  125. Tavares, Ana; Louro, Henriqueta; Alvito, Paula; Silva, Maria João. "Interactive effects of aflatoxin M1 and ochratoxin A in a human intestinal cell line: evaluation of cyto- and genotoxicity". 2011.
  126. Silva, Maria João; Carmo, Susana; Tavares, Ana; Louro, Henriqueta. "Evaluation of the genotoxic and cytotoxic effects of titanium dioxide nanoparticles in human lymphocytes". 2011.
  127. Tavares, Ana; Antunes, Susana; Louro, Henriqueta; Lavinha, João; Silva, Maria João. "Nanosized Titanium Dioxide Particles: Evaluation of Genotoxic Effects in Human Lymphocytes". 2011.
  128. Pinto, Miguel; Louro, Henriqueta; Costa, Pedro; Caeiro, Sandra; Lavinha, João; Silva, Maria João. "Impact of Potentially Contaminated Sediments From The Sado Estuary in Human Health: Cytotoxic And Genotoxic Assays in a Human Cell Line". 2011.
  129. Vital, Nádia; Antunes, Susana; Louro, Henriqueta; Penque, Deborah; Simões, Tânia; Silva, Maria João. "Fumo de Tabaco em Estabelecimentos Recreativos: Biomarcadores de Genotoxicidade e Susceptibilidade Genética". 2011.
  130. Pinto, Miguel; Louro, Henriqueta; Costa, Pedro; Costa, Maria Helena; Caeiro, Sandra; Silva, Maria João. "Cytotoxic and genotoxic assessment of potentially contaminated sediments from the Sado Estuary". 2011.
  131. Antunes, Susana; Vital, Nadia; Louro, Henriqueta; Gomes, Filomena; Penque, Deborah; Simões, Tânia; Silva, Maria João. "Exposição ao Fumo Passivo no Local de Trabalho: Biomarcadores de Genotoxicidade e Susceptibilidade". 2011.
  132. Louro, Henriqueta; Carmo, Susana; Vital, Nádia; Gomes, Filomena; Penque, Deborah; Simões, Tânia; Silva, Maria João. "Exposure to second-hand smoke in occupational settings: biomarkers of DNA damage and susceptibility". 2011.
    doi: 10.1093/mutage/ger026
  133. Rebola, Marlene; Pinto, Miguel; Louro, Henriqueta; Antunes, A.M.M.; José, S.S.; Rocha, M.R.; Silva, Maria João; Cardoso, Ana Sofia. "Formation of emerging disinfection byproducts in water and evaluation of potential genotoxic effects: the case of chlorinated polycyclic aromatic hydrocarbons". 2011.
  134. Simões, Tânia; Milic, Vukosava D.; Pacheco, S.A.; Aguiar, Fátima; Gomes, Filomena; Louro, Henriqueta; Vital, Nádia; et al. "Tobacco Smoke Occupational Exposure: Biomarkers of Biological Damage". 2011.
Conference poster
  1. Fátima Pinto; Célia Ventura; Sara Teixeira; Lourenço, Ana Filipa; Susete N Fernandes; Rafaela R da Rosa; Maria Helena Godinho; et al. "Exploring potential genotoxic effects of nenocelluloses versus multiwalled carbon nanotubes in cocultures of human lung epithelial cells and monocyte-derived macrophages". Paper presented in e Environmental Mutagenesis and Genomics Society 52nd Annual Meeting, 2021.
    10.1002/em.22458
  2. Rolo, Dora; Ricardo Assunção; Silva, Maria João; Louro, Henriqueta. "Systematic Literature Reviews as a tool to develop Adverse Outcome Pathways landscapes in Nanotoxicology: case study of ingested Titanium dioxide nanomaterials". Paper presented in 2nd International Online-Conference on Nanomaterials (IOCN), 2020.
  3. Vieira, Adriana; Gramacho, Ana; Rolo, Dora; Vital, Nádia; Godinho-Pereira, Joana; Matos, Paulo; Jordan, Peter; et al. "Biological effects of ingested nanomaterials and potential adverse outcomes for human health". Paper presented in Encontro Ciência 2020, 2020.
  4. Maria João Aleixo da Silva; Louro, Henriqueta; Susana Viegas; Gomes, BC; Tiina Santonen; Andreas Kortenkamp; Erik Lebret. "A Case Study On Occupational Exposure To Chromium (Vi), Nickel, Pah Mixtures And Lung Cancer". Paper presented in 11th International Symposium on Biological Monitoring in Occupational and Environmental Health, 2019.
  5. Gomes, BC; Louro, Henriqueta; Pasi Huuskonen; Tiina Santonen; Katriina Huumonen; Sophie Ndaw; Mariana F. Fernández; Maria João Aleixo da Silva. "The use of effect biomarkers in hexavalent chromium human biomonitoring studies: a critical review". Paper presented in ISES Europe 2019, 2019.
  6. Barros, Patrícia; Amaral, Andreia J.; Abrantes, Leonor B.; Oliveira, Tiago; Louro, Henriqueta; Silva, Maria J.; Jordan, Peter; Gama-Carvalho, Margarida; Matos, Paulo. "Stimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via STAT5 stimulation of BCL6 repressed loci". Paper presented in 2º Dia do Jovem Investigador do Instituto Nacional de Saúde Doutor Ricardo Jorge, 2017.
  7. Gouveia, Helena; VItal, Nádia; Alberto, Rita; Silva, Maria; Louro, Henriqueta; Saraiva, Fernanda; Borges, Teresa; Lavinha, João. "A Portuguese Contribuition to the nanomatetrials regulation". Paper presented in NanoPT2014 International Conference, Porto, 2014, 2014.
  8. Simões, T; Aguiar, F; Ruivo, P; Gomes, F; Louro, Henriqueta; Vital, Nádia; Antunes, S; et al. "Tobacco smoke at recreation establishments: health effects and biological damage". Paper presented in ECNIS, International Workshop on Biomarkers and Cancer, Porto, Portugal, 2009, 2009.
Edited book
  1. Louro, Henriqueta; Silva, Maria João. Nanotoxicology in safety assessment of nanomaterials. Switzerland: Springer Nature Switzerland AG. 2022.
    In press • DOI 10.1007/978-3-030-88071-2 • Editor
  2. Namorado, Sónia; Assunção, Ricardo; Silva, Maria João; Louro, Henriqueta; Alvito, Paula; Lavinha, João; Dias, Carlos; et al. 1st Workshop on Human Biomonitoring in Portugal "Briding Chemical Exposure to Human Health": Programme and Abstract Book. Portugal: Instituto Nacional de Saúde Doutor Ricardo Jorge, IP. 2018.
  3. Alvito, Paula; Assunção, Ricardo; Louro, Henriqueta; Silva, Maria João; Vasco, Elsa. Food contaminants and human health: challenges in chemical mixtures. Portugal: National Institute of Health Doutor Ricardo Jorge. 2016.
Journal article
  1. Susana Viegas; Carla Martins; Edna Ribeiro; Carina Ladeira; Hermínia Pinhal ; Ana Nogueira; Sílvia Santos; et al. Corresponding author: Louro, Henriqueta. "HBM4EU chromates study: the Portuguese integrated and harmonized study on exposure to hexavalent chromium and related early effects". Annals of Work Exposures and Health (2024): wxae091. https://doi.org/10.1093/annweh/wxae091.
    Published
  2. Rolo, Dora; Pereira, Joana FS; Gonçalves, Lídia; Bettencourt, Ana; Jordan, Peter; Silva, Maria João; Matos, Paulo; Louro, Henriqueta. "Assessing the impact of TiO2 nanomaterials on intestinal cells: new evidence for epithelial translocation and potential pro-inflammatory effects". Toxicology (2024):
    Accepted
  3. Castle, Laurence; Andreassen, Monica; Aquilina, Gabriele; Bastos, Maria; Boon, Polly; Fallico, Biagio; FitzGerald, Reginald; et al. "Flavouring group evaluation 420 (FGE.420): Hesperetin dihydrochalcone". EFSA Journal 22 12 (2024): https://doi.org/10.2903/j.efsa.2024.9091.
    10.2903/j.efsa.2024.9091
  4. Castle, Laurence; Andreassen, Monica; Aquilina, Gabriele; Bastos, Maria Lourdes; Boon, Polly; Fallico, Biagio; FitzGerald, Reginald; et al. "Scientific opinion on the extension of the authorisation of use of the food additive steviol glycosides (E 960a–d) and the modification of the acceptable daily intake (ADI) for steviol". EFSA Journal 22 11 (2024): https://doi.org/10.2903/j.efsa.2024.9045.
    10.2903/j.efsa.2024.9045
  5. Castle, Laurence; Andreassen, Monica; Aquilina, Gabriele; Bastos, Maria Lourdes; Boon, Polly; Fallico, Biagio; FitzGerald, Reginald; et al. "Re-evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives". EFSA Journal 22 11 (2024): https://doi.org/10.2903/j.efsa.2024.9044.
    10.2903/j.efsa.2024.9044
  6. Mhaouty-Kodja, Sakina; Zalko, Daniel; Tait, Sabrina; Testai, Emanuela; Viguié, Catherine; Corsini, Emanuela; Grova, Nathalie; et al. "A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health". Critical Reviews in Toxicology (2024): 1-58. https://doi.org/10.1080/10408444.2024.2388712.
    10.1080/10408444.2024.2388712
  7. Castle, Laurence; Andreassen, Monica; Aquilina, Gabriele; Bastos, Maria; Boon, Polly; Fallico, Biagio; Fitzgerald, Reginald; et al. "Re-evaluation of argon (E 938) and helium (E 939) as food additives". EFSA Journal 22 10 (2024): https://doi.org/10.2903/j.efsa.2024.9048.
    10.2903/j.efsa.2024.9048
  8. Henriqueta Louro; Ariane Vettorazzi; Adela López de Cerain; Anastasia Spyropoulou; Anita Solhaug; Anne Straumfors; Anne-Cathrin Behr; et al. "Author Correction: Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health". Archives of Toxicology (2024): https://doi.org/10.1007/s00204-024-03818-y.
    10.1007/s00204-024-03818-y
  9. Andreassen, Monica; Aquilina, Gabriele; Bastos, Maria Lourdes; Boon, Polly; Fallico, Biagio; FitzGerald, Reginald; Frutos Fernandez, Maria Jose; et al. "Safety evaluation of curdlan as a food additive". EFSA Journal 22 9 (2024): https://doi.org/10.2903/j.efsa.2024.8985.
    10.2903/j.efsa.2024.8985
  10. Castle, Laurence; Andreassen, Monica; Aquilina, Gabriele; Bastos, Maria; Boon, Polly; Fallico, Biagio; Fitzgerald, Reginald; et al. "Flavouring Group Evaluation 80, Revision 2 (FGE.80Rev2): Consideration of alicyclic, alicyclic-fused and aromatic-fused ring lactones evaluated by the JECFA (61st and 82nd meetings) structurally related to an aromatic lactone evaluated in FGE.27". EFSA Journal 22 8 (2024): https://doi.org/10.2903/j.efsa.2024.8952.
    10.2903/j.efsa.2024.8952
  11. Stayner, Leslie T; Carreón-Valencia, Tania; Demers, Paul A; Fritz, Jason M; Sim, Malcolm R; Stewart, Patricia; Tsuda, Hiroyuki; et al. "Carcinogenicity of talc and acrylonitrile". The Lancet Oncology 25 8 (2024): 962-963. https://doi.org/10.1016/s1470-2045(24)00384-x.
    10.1016/s1470-2045(24)00384-x
  12. Vital, Nádia; Gramacho, Ana Catarina; Silva, Mafalda; Cardoso, Maria; Alvito, Paula; Kranendonk, Michel; Silva, Maria João; Louro, Henriqueta. "Challenges of the Application of In Vitro Digestion for Nanomaterials Safety Assessment". Foods 13 11 (2024): 1690. https://doi.org/10.3390/foods13111690.
    10.3390/foods13111690
  13. Bampidis, Vasileios; Azimonti, Giovanna; Bastos, Maria de Lourdes; Christensen, Henrik; Dusemund, Birgit; Durjava, Mojca; Kouba, Maryline; et al. "Safety and efficacy of a feed additive consisting of 6-phytase produced by Aspergillus oryzae DSM 33737 (HiPhorius™) for all poultry, all Suidae and all fin fish (DSM Nutritional Products Ltd)". EFSA Journal 22 3 (2024): https://doi.org/10.2903/j.efsa.2024.8663.
    10.2903/j.efsa.2024.8663
  14. Henriqueta Louro; Ariane Vettorazzi; Adela López de Cerain; Anastasia Spyropoulou; Anita Solhaug; Anne Straumfors; Anne-Cathrin Behr; et al. "Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health". Archives of Toxicology (2024): https://doi.org/10.1007/s00204-023-03636-8.
    10.1007/s00204-023-03636-8
  15. Cseresznye, Adam; Hardy, Emilie M.; Ait Bamai, Yu; Cleys, Paulien; Poma, Giulia; Malarvannan, Govindan; Scheepers, Paul T.J.; et al. "HBM4EU E-waste study: Assessing persistent organic pollutants in blood, silicone wristbands, and settled dust among E-waste recycling workers in Europe". Environmental Research (2024): 118537. http://dx.doi.org/10.1016/j.envres.2024.118537.
    10.1016/j.envres.2024.118537
  16. Célia Ventura; Fátima Pinto; Ana Filipa Lourenço; Jorge F. S. Pedrosa; Susete N. Fernandes; Rafaela R. da Rosa; Maria Helena Godinho; et al. "Assessing the Genotoxicity of Cellulose Nanomaterials in a Co-Culture of Human Lung Epithelial Cells and Monocyte-Derived Macrophages". Bioengineering (2023): https://doi.org/10.3390/bioengineering10080986.
    10.3390/bioengineering10080986
  17. Nakayama, Shoji F.; St-Amand, Annie; Pollock, Tyler; Apel, Petra; Bamai, Yu Ait; Barr, Dana Boyd; Bessems, Jos; et al. "Interpreting biomonitoring data: Introducing the international human biomonitoring (i-HBM) working group's health-based guidance value (HB2GV) dashboard". International Journal of Hygiene and Environmental Health 247 (2023): 114046. http://dx.doi.org/10.1016/j.ijheh.2022.114046.
    10.1016/j.ijheh.2022.114046
  18. Cleys, Paulien; Hardy, Emilie; Ait Bamai, Yu; Poma, Giulia; Cseresznye, Adam; Malarvannan, Govindan; Scheepers, Paul T.J.; et al. "HBM4EU e-waste study: Occupational exposure of electronic waste workers to phthalates and DINCH in Europe". (2023): http://hdl.handle.net/10400.18/8787.
    10.1016/j.ijheh.2023.114286
  19. Nádia Vital; Célia Ventura; Michel Kranendonk; Maria João Silva; Henriqueta Louro. "Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure". Nanomaterials (2022): https://doi.org/10.3390/nano12193375.
    10.3390/nano12193375
  20. Dora Rolo; Ricardo Assunção; Célia Ventura; Alvito P; Lídia Gonçalves; Carla Martins; Bettencourt A.; et al. "Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles—A Systematic Review". Nanomaterials (2022): https://www.mdpi.com/2079-4991/12/19/3275.
    10.3390/nano12193275
  21. Henriqueta Louro; Bruno Costa Gomes; Anne Thoustrup Saber; Anna Laura Iamiceli; Thomas Göen; Kate Jones; Andromachi Katsonouri; et al. "The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review". Toxics (2022): https://doi.org/10.3390/toxics10080480.
    10.3390/toxics10080480
  22. Ana Tavares; Kukka Aimonen; Sophie Ndaw; Aleksandra Fucic; Julia Catalán; Radu - Corneliu Duca; Lode Godderis; et al. "HBM4EU Chromates Study—Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium". Toxics (2022): https://www.mdpi.com/2305-6304/10/8/483.
    10.3390/toxics10080483
  23. Ana Maria Tavares; Susana Viegas; Henriqueta Louro; Thomas Göen; Tiina Santonen; Mirjam Luijten; Andreas Kortenkamp; Maria João Silva. "Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries". Toxics (2022): https://doi.org/10.3390/toxics10080431.
    10.3390/toxics10080431
  24. Kate Jones; Karen S. Galea; Bernice Scholten; Marika Loikala; Simo P. Porras; Radia Bousoumah; Sophie Ndaw; et al. "HBM4EU Diisocyanates Study—Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure". International Journal of Environmental Research and Public Health (2022): https://doi.org/10.3390/ijerph19148811.
    10.3390/ijerph19148811
  25. Fátima Pinto; Ana Filipa Lourenço; Jorge Pedrosa; Lídia Gonçalves; Célia Ventura; Nádia Vital; Bettencourt A.; et al. "Analysis of the In Vitro Toxicity of Nanocelluloses in Human Lung Cells as Compared to Multi-Walled Carbon Nanotubes". Nanomaterials (2022): https://www.mdpi.com/2079-4991/12/9/1432.
    10.3390/nano12091432
  26. Célia Ventura; Catarina Marques; João Cadete; Madalena Vilar; Jorge Pedrosa; Fátima Pinto; Fernandes, S.; Fernandes, S. N.; Fernandes, Susete N;; et al. "Genotoxicity of Three Micro/Nanocelluloses with Different Physicochemical Characteristics in MG-63 and V79 Cells". Journal of Xenobiotics (2022): https://www.mdpi.com/2039-4713/12/2/9.
    10.3390/jox12020009
  27. Adriana Vieira; Nádia Vital; Dora Rolo; Rossana Roque; Lídia M. Gonçalves; Ana Bettencourt; Maria João Silva; Henriqueta Louro. "Investigation of the genotoxicity of digested titanium dioxide nanomaterials in human intestinal cells". Food and Chemical Toxicology 161 (2022): 112841-112841. https://doi.org/10.1016/j.fct.2022.112841.
    10.1016/j.fct.2022.112841
  28. Moreira, Rodrigo; Tavares, Ana M.; Louro, Henriqueta; Ventura, Célia; Ladeira, Carina; Viegas, Susana; Silva, Maria João. "Exposição a substâncias químicas na indústria da gestão de resíduos elétricos e eletrónicos e seus potenciais efeitos na saúde dos trabalhadores". (2022): http://hdl.handle.net/10400.18/8034.
  29. Ventura, Célia; Pinto, Fátima; Marques, Catarina; Cadete, João; Vilar, Madalena; Lourenço, Ana Filipa; Pedrosa, Jorge F. S.; et al. "Toxicidade da nanocelulose em modelos in vitro: um contributo para a avaliação da sua segurança para a saúde humana". (2022): http://hdl.handle.net/10400.18/8261.
  30. Paul T. J. Scheepers; Radu Corneliu Duca; Karen S. Galea; Lode Godderis; Emilie Hardy; Lisbeth E. Knudsen; Elizabeth Leese; et al. "HBM4EU Occupational Biomonitoring Study on e-Waste—Study Protocol". International Journal of Environmental Research and Public Health (2021): https://doi.org/10.3390/ijerph182412987.
    10.3390/ijerph182412987
  31. Louro, Henriqueta. "HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium.". Environmental research (2021): https://doi.org/10.1016/j.envres.2021.111984.
    10.1016/j.envres.2021.111984
  32. Karen S. Galea; Simo P. Porras; Susana Viegas; Beatrice Bocca; Radia Bousouma; Radu Corneliu Duca; Lode Godderis; Ivo Iavicoli; Beata Janasik; Kate Jones; Lisbeth E. Knudsen; Elizabeth Leese; Veruscka Leso; Louro, Henriqueta; Sophie Ndaw; Flavia Ruggieri; Ovnair Sepai; Paul T.J. Scheepers; Maria J. Silva; Wojciech Wasowicz; Tiina Santonen. "HBM4EU Chromate Study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium". International Journal of Hygiene and Environmental Health (2021):
    Accepted
  33. Célia Ventura; Bruno Costa Gomes; Axel Oberemm; Louro, Henriqueta; Pasi Huuskonen; Vicente Mustieles; Mariana F. Fernández; et al. "Biomarkers of effect as determined in human biomonitoring studies on hexavalent chromium and cadmium in the period 2008-2020". Environmental Research (2021):
    Accepted
  34. Milic, Mirta; Ceppi, Marcello; Bruzzone, Marco; Azqueta, Amaya; Brunborg, Gunnar; Godschalk, Roger; Koppen, Gudrun; et al. "The hCOMET project: international database comparison of results with the comet assay in human biomonitoring (baseline frequency of DNA damage and effect of main confounders)". (2021): http://hdl.handle.net/10400.21/12956.
    10.1016/j.mrrev.2021.108371
  35. Zare Jeddi, Maryam; Hopf, Nancy B.; Viegas, Susana; Price, Anna Bal; Paini, Alicia; van Thriel, Christoph; Benfenati, Emilio; et al. "Towards a systematic use of effect biomarkers in population and occupational biomonitoring". Environment International 146 (2021): 106257. http://hdl.handle.net/10362/110973.
    Published • https://doi.org/10.1016/j.envint.2020.106257
  36. Vital, Nádia; Antunes, Susana; Louro, Henriqueta; Vaz, Fátima; Simões, Tânia; Penque, Deborah; Silva, Maria João. "Environmental Tobacco Smoke in Occupational Settings". (2021): http://hdl.handle.net/10362/120609.
    https://doi.org/10.3389/fpubh.2021.674142
  37. Zare Jeddi, Maryam; Virgolino, Ana; Fantke, Peter; Hopf, Nancy B.; Galea, Karen S.; Remy, Sylvie; Viegas, Susana; et al. "A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles". (2021): http://hdl.handle.net/10400.18/7784.
    10.1016/j.ijheh.2021.113826
  38. Vital, Nádia; Antunes, Susana; Louro, Henriqueta; Vaz, Fátima; Simões, Tânia; Penque, Deborah; Silva, Maria João. "Environmental Tobacco Smoke in Occupational Settings: Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars". Frontiers in Public Health 9 (2021): http://hdl.handle.net/10400.18/7841.
    10.3389/fpubh.2021.674142
  39. Pinhão, M.; Tavares, A.M.; Loureiro, S.; Louro, H.; Alvito, P.; Silva, M.J.. "Combined cytotoxic and genotoxic effects of ochratoxin A and fumonisin B1 in human kidney and liver cell models". Toxicology in Vitro 68 (2020): 104949. http://dx.doi.org/10.1016/j.tiv.2020.104949.
    Published • 10.1016/j.tiv.2020.104949
  40. Ventura, Célia; Pinto, Fátima; Lourenço, Ana Filipa; Ferreira, Paulo J. T.; Louro, Henriqueta; Silva, Maria João. "On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models". Cellulose 27 10 (2020): 5509-5544. http://dx.doi.org/10.1007/s10570-020-03176-9.
    Published • 10.1007/s10570-020-03176-9
  41. Bettencourt, Ana; Gonçalves, Lídia M; Gramacho, Ana C; Vieira, Adriana; Rolo, Dora; Martins, Carla; Assunção, Ricardo; et al. "Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro Digestion". (2020): http://hdl.handle.net/10400.18/7208.
    10.3390/nano10081516
  42. Susana Viegas, Bruno Costa Gomes, Henriqueta Louro, Maria João Silva, Agnes Šömen Joksic, Stanislava Kirincic, Selma Mah; Viegas, Susana; Gomes, Bruno Costa; Louro, Henriqueta; Silva, Maria João; Joksic, Agnes ¿ömen; Kirincic, Stanislava; Mahiout, Selma; Santonen, Tiina. "Using Human Biomonitoring for the Risk Assessment of Polycyclic Aromatic Hydrocarbons in Occupational Exposures". Toxicology Letters 314S1 10 (2019): S76-S76.
    Published
  43. Louro, Henriqueta; Santonen, Tiina; Alimonti, Alessandro; Bocca, Beatrice; Duca, Radu Corneliu; Galea, Karen S.; Godderis, Lode; et al. "Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium.". Environmental research (2019): https://doi.org/10.1016/j.envres.2019.108583.
    10.1016/j.envres.2019.108583
  44. Louro, Henriqueta; Louro, Henriqueta; Heinälä, Milla; Bessems, Jos; Buekers, Jurgen; Vermeire, Theo; Woutersen, Marjolijn; et al. "Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future". International Journal of Hygiene and Environmental Health 248 (2019): 114099. http://dx.doi.org/10.1016/j.ijheh.2019.05.009.
    10.1016/j.ijheh.2019.05.009
  45. Vasconcelos, Ana Luísa; Silva, Maria João; Louro, Henriqueta. "In vitro exposure to the next-generation plasticizer diisononyl cyclohexane-1,2-dicarboxylate (DINCH): cytotoxicity and genotoxicity assessment in human cells". Journal of Toxicology and Environmental Health, Part A 82 9 (2019): 526-536. http://dx.doi.org/10.1080/15287394.2019.1634376.
    Published • 10.1080/15287394.2019.1634376
  46. Henriqueta Louro; Andreia Saruga; Joana Santos; Mariana Pinhão; Maria João Silva; Louro, Henriqueta; Saruga, Andreia; et al. "Biological impact of metal nanomaterials in relation to their physicochemical characteristics". Toxicology in Vitro (2019): https://doi.org/10.1016/j.tiv.2019.01.018.
    10.1016/j.tiv.2019.01.018
  47. Gramacho, Ana Catarina; Silva, Maria João; Louro, Henriqueta. "Nanomateriais ingeridos: impacto biológico e relação com as suas características físico-químicas". (2019): http://hdl.handle.net/10400.18/6392.
  48. Graça, Diogo; Louro, Henriqueta; Santos, Joana; Dias, Kamila; Almeida, Antonio J.; Gonçalves, Lídia; Silva, Maria João; Bettencourt, Ana. "Toxicity screening of a novel poly(methylmethacrylate)-Eudragit nanocarrier on L929 fibroblasts". Toxicology Letters 276 (2017): 129-137. http://dx.doi.org/10.1016/j.toxlet.2017.05.017.
    10.1016/j.toxlet.2017.05.017
  49. Henriqueta Louro; Mariana Pinhão; Joana Santos; Ana Tavares; Nádia Vital; Maria João Silva. "Evaluation of the cytotoxic and genotoxic effects of benchmark multi-walled carbon nanotubes in relation to their physicochemical properties". Toxicology Letters 262 (2016): 123-134. https://doi.org/10.1016%2Fj.toxlet.2016.09.016.
    10.1016/j.toxlet.2016.09.016
  50. Costa JG; Saraiva N; Guerreiro PS; Louro H; Silva MJ; Miranda JP; Castro M; et al. "Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints.". (2016): http://europepmc.org/abstract/med/26627377.
    10.1016/j.fct.2015.11.018
  51. Pinto, Miguel Ferreira; Louro, Henriqueta; Costa, Pedro M.; Caeiro, Sandra; Silva, Maria João; Pinto, Miguel; Costa, Pedro; et al. "Exploring the Potential Interference of Estuarine Sediment Contaminants with the DNA Repair Capacity of Human Hepatoma Cells". Journal of Toxicology and Environmental Health, Part A 78 9 (2015): 559-570. http://dx.doi.org/10.1080/15287394.2015.1006712.
    Published • 10.1080/15287394.2015.1006712
  52. Tarantini, A.; Huet, S.; Jarry, G.; Lanceleur, R.; Poul, M.; Tavares, A.; Vital, N.; et al. "Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 1: Oral route". Environmental and Molecular Mutagenesis 56 2 (2015): 218-227. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925302162&partnerID=MN8TOARS.
    10.1002/em.21935
  53. Costa, Pedro M.; Pinto, Miguel; Vicente, Ana M.; Gonçalves, Cátia; Rodrigo, Ana P.; Louro, Henriqueta; Costa, Maria H.; et al. "An integrative assessment to determine the genotoxic hazard of estuarine sediments: combining cell and whole-organism responses". Frontiers in Genetics 5 DEC (2014): http://dx.doi.org/10.3389/fgene.2014.00437.
    10.3389/fgene.2014.00437
  54. Pinto, Miguel; Rebola, Marlene; Louro, Henriqueta; Antunes, Alexandra M. M.; José, Silvia S.; Rocha, Maria; Silva, Maria João; et al. "Chlorinated Polycyclic Aromatic Hydrocarbons Associated with Drinking Water Disinfection: Synthesis, Formation under Aqueous Chlorination Conditions and Genotoxic Effects". Polycyclic Aromatic Compounds 34 4 (2014): 356-371. http://dx.doi.org/10.1080/10406638.2014.891143.
    10.1080/10406638.2014.891143
  55. Pinto, M.; Costa, P.M.; Louro, H.; Costa, M.H.; Lavinha, J.; Caeiro, S.; Silva, M.J.; et al. "Determining oxidative and non-oxidative genotoxic effects driven by estuarine sediment contaminants on a human hepatoma cell line". Science of The Total Environment 478 (2014): 25-35. http://dx.doi.org/10.1016/j.scitotenv.2014.01.084.
    10.1016/j.scitotenv.2014.01.084
  56. Louro, Henriqueta; Tavares, Ana; Vital, Nádia; Costa, Pedro M.; Alverca, Elsa; Zwart, Edwin; de Jong, Wim H.; et al. "Integrated approach to the in vivo genotoxic effects of a titanium dioxide nanomaterial usingLacZplasmid-based transgenic mice". Environmental and Molecular Mutagenesis 55 6 (2014): 500-509. http://dx.doi.org/10.1002/em.21864.
    10.1002/em.21864
  57. Tavares, A.M.; Louro, H.; Antunes, S.; Quarré, S.; Simar, S.; De Temmerman, P.-J.; Verleysen, E.; et al. "Genotoxicity evaluation of nanosized titanium dioxide, synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes". Toxicology in Vitro 28 1 (2014): 60-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888287360&partnerID=MN8TOARS.
    10.1016/j.tiv.2013.06.009
  58. Pinto, M.; Costa, P.M.; Louro, H.; Costa, M.H.; Lavinha, J.; Caeiro, S.; Silva, M.J.; et al. "Human hepatoma cells exposed to estuarine sediment contaminant extracts permitted the differentiation between cytotoxic and pro-mutagenic fractions". Environmental Pollution 185 (2014): 141-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888599414&partnerID=MN8TOARS.
    10.1016/j.envpol.2013.10.034
  59. Louro A; Peralta L; Soares S; Pereira A; Cunha G; Belchior A; Ferreira L; et al. "Human exposure to indoor radon: a survey in the region of Guarda, Portugal.". (2013): http://europepmc.org/abstract/med/22899215.
    10.1093/rpd/ncs166
  60. Tavares, A.M.; Alvito, P.; Loureiro, S.; Louro, H.; Silva, M.J.. "Multi-mycotoxin determination in baby foods and in vitro combined cytotoxic effects of aflatoxin M and ochratoxin A". World Mycotoxin Journal 6 4 (2013): 375-388. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885974209&partnerID=MN8TOARS.
    10.3920/WMJ2013.1554
  61. Louro, H.; Borges, T.; Silva, M.J.. "Manufactured nanomaterials: New challenges for public health | Nanomateriais manufaturados: novos desafios para a saúde pública". Revista Portuguesa de Saude Publica 31 2 (2013): 145-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890125673&partnerID=MN8TOARS.
    10.1016/j.rpsp.2012.12.004
  62. Louro,Henriqueta; Borges,Teresa; Silva,Maria João. "Nanomateriais manufaturados: novos desafios para a saúde pública". (2013): http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0870-90252013000200003.
  63. Louro H; Faustino I; Dias A; Boavida MG; Silva MJ. "Poly (ADP-ribose) polymerase-1 deficiency does not affect ethylnitrosourea mutagenicity in liver and testis of lacZ transgenic mice.". (2010): http://europepmc.org/abstract/med/20196134.
    10.1002/em.20555
  64. Louro H; Pinheiro I; Costa P; Sousa C; Dias A; Boavida MG; Silva MJ. "Mutagenic effects of poly (ADP-ribose) polymerase-1 deficiency in transgenic mice.". (2008): http://europepmc.org/abstract/med/18242645.
    10.1016/j.mrfmmm.2007.12.003
  65. Silva MJ; Costa P; Dias A; Valente M; Louro H; Boavida MG. "Comparative analysis of the mutagenic activity of oxaliplatin and cisplatin in the Hprt gene of CHO cells.". (2005): http://europepmc.org/abstract/med/15887215.
    10.1002/em.20138
  66. Louro H; Silva MJ; Boavida MG. "Mutagenic activity of cisplatin in the lacZ plasmid-based transgenic mouse model.". (2002): http://europepmc.org/abstract/med/12489119.
    10.1002/em.10118
Newsletter article
  1. Rodrigo Moreira; Ana M. Tavares; Louro, Henriqueta; Célia Ventura; Carina Ladeira; Susana Viegas; Maria João Siva. "Exposure to chemicals in the e-waste management industry and potential health effects on workers", Boletim Epidemiológico Observações, 2022
  2. Tavares, Ana; Kukka Aimonen; Ndaw, Sophie; Fucic, Aleksandra; Catalán, Julia; Duca, Radu Corneliu; Godderis, Lode; et al. "Genotoxicity biomarkers in workers exposed to hexavalent chromium: a study under the European Human Biomonitoring Initiative", Boletim Epidemiológico Observações., 2022, http://hdl.handle.net/10400.18/8397..
Report
  1. SCCS (Scientific Committee on Consumer Safety), U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, J. Ezendam, E. Gaff. 2024. Opinion on the inhalation toxicity of the fragrance ingredient Acetylated Vetiver Oil – AVO (CAS No 84082-84-8, EC No 282-031-1) in sprayable cosmetic products - Submission IV, SCCS/1663/24, SCCS/1663/24.. https://health.ec.europa.eu/publications/sccs-opinion-inhalation-toxicity-fragrance-ingredient-acetylated-vetiver-oil-avo-cas-no-84082-84-8_en.
  2. SCCS (Scientific Committee on Consumer Safety), U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, J. Ezendam, E. Gaff. 2024. Scientific advice on hair dye HC Yellow No. 16 (Colipa No B123) (CAS No. 1184721-10-5) – Submission II,, SCCS/1670/24.. https://health.ec.europa.eu/publications/sccs-scientific-advice-hc-yellow-no-16-colipa-no-b123-cas-no-1184721-10-5-submission-ii_en.
  3. SCCS (Scientific Committee on Consumer Safety), U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, J. Ezendam, E. Gaffe. 2024. ADDENDUM to the SCIENTIFIC OPINION on Hexyl Salicylate SCCS/1658/23 (CAS/EC No. 6259-76-3/228-408-6) - - Children exposure 0-3 years old - SCCS/1668/24. https://health.ec.europa.eu/publications/sccs-addendum-scientific-opinion-hexyl-salicylate-sccs165823-casec-no-6259-76-3228-408-6-children_en.
  4. SCCS (Scientific Committee on Consumer Safety), U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, J. Ezendam, E. Gaffe. 2024. Opinion on the safety of ‘Biphenyl-2-ol’ and ‘Sodium 2-biphenylolate’ (CAS/EC No. 90-43-7/201-993-5 and 132-27-4/205-055-6) used in cosmetic products, SCCS/1669/24.. https://health.ec.europa.eu/publications/sccs-opinion-biphenyl-2-ol-and-sodium-2-biphenylolate-used-cosmetic-products-casec-no-90-43-7201-993_en.
  5. SCCS (Scientific Committee on Consumer Safety), U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, J. Ezendam, E. Gaffe. 2024. Opinion on Citral (CAS No. 5392-40-5, EC No. 226-394-6) - sensitisation endpoint. , https://health.ec.europa.eu/publications/sccs-opinion-citral-cas-no-5392-40-5-ec-no-226-394-6-sensitisation-endpoint_en.
  6. SCCS (Scientific Committee on Consumer Safety), U. Bernauer L. Bodin Q. Chaudhry, PJ. Coenraads, M. Dusinska, J. Ezendam. 2024. Opinion on triphenyl phosphate (CAS No. 204-112-2, EC No. 115-86-6).. https://health.ec.europa.eu/publications/sccs-opinion-triphenyl-phosphate-cas-no-204-112-2-ec-no-115-86-6_en.
  7. SCCS (Scientific Committee on Consumer Safety), U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, J. Ezendam, E. Gaffe. 2024. Opinion on the safety of Silver (CAS/EC No. 7440-22-4/231-131-3) used in cosmetic products,, SCCS/1665/24. https://health.ec.europa.eu/publications/sccs-opinion-safety-silver-casec-no-7440-22-4231-131-3-used-cosmetic-products_en.
  8. SCCS (Scientific Committee on Consumer Safety), U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, J. Ezendam, E. Gaffe. 2024. Scientific Advice on Titanium dioxide (TiO2), CAS/EC numbers 13463-67-7/236-675-5, 1317-70-0/215-280- 1, 1317-80-2/215-282-2. https://health.ec.europa.eu/publications/scientific-advice-titanium-dioxide-tio2-casec-numbers-13463-67-7236-675-5-1317-70-0215-280-1-1317-80_en - repositado em 2023.
  9. SCCS (Scientific Committee on Consumer Safety), U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Eze. 2024. SCCS OPINION on benzophenone – 4 (CAS No. 4065-45-6, EC No. 223-772-2) - SCCS/1660/23. The SCCS adopted this document by written procedure on 14 December 2023. https://health.ec.europa.eu/publications/benzophenone-4-cas-no-4065-45-6-ec-no-223-772-2_en.
  10. SCCS (Scientific Committee on Consumer Safety), U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Eze. 2024. SCCS OPINION on the safety of aluminium in cosmetic products - Submission IV - SCCS/1662/23. https://health.ec.europa.eu/publications/safety-aluminium-cosmetic-products-submission-iv_en.
  11. SCCS (Scientific Committee on Consumer Safety), U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, J. Ezendam, E. Gaffe. 2024. Opinion on benzophenone – 4 (CAS No. 4065-45-6, EC No. 223-772-2) used in cosmetics products.. https://health.ec.europa.eu/latest-updates/sccs-final-opinion-benzophenone-4-2024-04-04_en.
  12. SCCS (Scientific Committee on Consumer Safety), U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, J. Ezendam, E. Gaff. 2024. Scientific Opinion on Hexyl Salicylate (CAS/EC No. 6259-76-3/228-408-6) - SCCS/1658/23 - Final version. https://health.ec.europa.eu/publications/hexyl-salicylate-casec-no-6259-76-3228-408-6_en.
  13. SCCS (Scientific Committee on Consumer Safety), U. Bernauer L. Bodin Q. Chaudhry, PJ. Coenraads, M. Dusinska, J. Ezendam. 2024. Opinion on Hydroxypropyl p-phenylenediamine and its dihydrochloride salt (A165) (CAS/EC No. 73793-79-0/827-723-1 and 1928659-47-5/-), SCCS/1659/23.. https://health.ec.europa.eu/publications/hydroxypropyl-p-phenylenediamine-and-its-dihydrochloride-salt-a165-casec-no-73793-79-0827-723-1-and_en.
  14. Andreas Kortenkamp; Anne Marie Vinggaard; Marcel Mengelers; Remy Slama; Maria João Silva; Louro, Henriqueta; Susana Viegas; et al. Corresponding author: Andreas Kortenkamp. 2021. Deliverable Report D15.5 - Case study reports on mixture health effects. https://www.hbm4eu.eu/result/deliverables/.
    10.5281/zenodo.6602142
  15. Vicente, Joana Lobo; Katsonouri, Andromachi; Reynders, Hans; Van Campenhout, Karen; Mampaey, Maja; Tarroja, Elena; Louro, Henriqueta; et al. 2021. Revised report on national needs, objectives of a long-term HBM4EU inventory of funding mechanisms and recommendations for a sustainable HBM initiative in Europe and its organisation. http://hdl.handle.net/10400.18/8323.
  16. Joana Lobo Vicente; Andromachi Katsonouri; Hans Reynders; Karen Van Campenhout; Elena Tarroja; Louro, Henriqueta; Glória Isidro; et al. 2020. Additional Deliverable Report AD6.2 WP6 - Sustainability and capacity building. Results of the interaction and surveys with the Environment Protection Agency network and the National Reference Centre on Environment & Health.. https://www.hbm4eu.eu/deliverables/.
  17. Lobo Vicente, Joana; Katsonouri, Andromachi; Hans, Reynders; Campenhout, Karen Van; Tarroja, Elena; Louro, Henriqueta; Isidro, Glória; et al. 2020. AD6.2 WP6 - Sustainability and capacity building. Results of the interaction and surveys with the Environment Protection Agency network and the National Reference Centre on Environment & Health. http://hdl.handle.net/10400.18/7554.
  18. Louro, Henriqueta. 2019. Deliverable Report D 5.5: Human biomonitoring in risk assessment: 2nd set of examples on the use of HBM in risk assessments of HBM4EU priority chemicals. http://hdl.handle.net/10400.18/6914.
  19. Louro, Henriqueta. 2019. Deliverable Report D 6.2. Revised set of key indicators. http://hdl.handle.net/10400.18/6915.
  20. Louro, Henriqueta. 2018. HBM4EU Project – Additional Deliverable 15.4 - Report on workshop associated with WP 15 on mixture risk assessment and case studies.. http://hdl.handle.net/10400.18/6376.
  21. Louro, Henriqueta. 2018. Deliverable Report D6.3 WP6 Sustainability and Capacity building- HBM4EU. http://hdl.handle.net/10400.18/6375.
  22. Ganzleben,  Catherine; Vicente, Joana Lobo; Barouki, Robert; Tarroja, Elena; Silva, Maria João; Isidro, Glória; Louro, Henriqueta; et al. 2018. Consultation on a sustainable HBM initiative in Europe - Deliverable Report D6.3 WP6 Sustainability and Capacity building.. http://hdl.handle.net/10400.18/6375.
  23. Kortemkamp, Andreas; Mengelers, Marcel; Vinggaard, Anne Marie; Silva, Maria João; Slamay, Remy; Vermeulen, Roel; Vlaanderen, Jelle; et al. 2018. Plan for development of case studies - Deliverable Report AD 15.1 WP 15 - Mixtures, HBM and human health risk. http://hdl.handle.net/10400.18/6376.
  24. Santonen, T.; Heinälä, M.; Bessems, J.; Buekers, J.; Cornelis, C.; Vermeire, T.; Woutersen, M.; et al. 2017. Human biomonitoring in risk assessment: analysis of the current practice and 1st examples HBM in risk assessments of HBM4EU priority chemicals. http://hdl.handle.net/10400.18/4847.
  25. Maria João Silva, Henriqueta Louro. 2016. NANoREG Project (GA 310584). Progress report. http://hdl.handle.net/10400.18/4617.
  26. Maria João Silva, Henriqueta Louro. 2016. NANoREG Project - 6th Six-Month Technical Report. http://hdl.handle.net/10400.18/4619.
  27. Penque, Deborah; Vieira, Luis; Gonçalves, João; Louro, Henriqueta; Silva, Maria João. 2016. Annual Scientific Report of the Center for Toxicogenomics and Human Health. http://hdl.handle.net/10400.18/4614.
  28. Norppa, Hannu; Siivola, Kirsi; Fessard, Valérie; Tarantini, Adeline; Apostolova, Margarita; Jacobsen, Nicklas Raun; Wallin, Håkan; et al. 2013. In vitro testing strategy for nanomaterials including database (Deliverable 5): final report. http://hdl.handle.net/10400.18/2081.
  29. Martinho, Ana Paula; Rodrigo, Ana; Vicente, Ana; Machado, Ausenda; Dias, Carlos Matias; Guiomar, Carla Sofia; Gonçalves, Cátia; et al. 2013. HERA - Environmental Risk Assessment of a contaminated estuarine environment: a case study. http://hdl.handle.net/10400.18/2322.
Thesis / Dissertation
  1. Teixeira, Sara Antunes de Almeida; Louro, Henriqueta; Silva, Maria João. "Biological effects of cellulose nanofibrils in a lung epithelial cell line". Master, 2019. http://hdl.handle.net/10400.18/6853.
  2. Leite, Ema; Silva, Maria João; Louro, Maria Henriqueta; Louro, Maria Henriqueta Dias Lourenço Garcia. "Nanomateriais manufaturados: avaliação de segurança através da caracterização dos seus efeitos genéticos". PhD, 2014. http://hdl.handle.net/10400.18/2324.
  3. Louro, Henriqueta. "Avaliação de efeitos genotóxicos em ratinhos transgénicos contendo o gene LacZ". Degree, Universidade de Lisboa Faculdade de Ciências, 1997.

Other

Other output
  1. Oral Exposure to Titanium dioxide nanoparticles: a Systematic Literature Review as a tool to develop Adverse Outcome Pathway landscapes and supporting in vitro assays. Despite being considered key enabling technologies, the exponential use of nanoparticles in food technology leads to concerns about adverse health outcomes upon ingestion. The use of Titanium dioxide nanoparticles (TiO2-NPs) as a food additive was considered no longer safe by the European Food Safety Authority (EFSA) in 2022, and the European Commission announced the decision to ban its use. Never. 2022. Rolo, Dora; Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/8343.
  2. Definition of an AOP landscape for ingested NMs. About definition of an Adverse Outcome Pathway landscape for ingested nanomaterials. FCT/MCTES através de fundos nacionais (PIDDAC), PTDC/SAU-PUB/29481/2017 and ToxOmics (UIDB/00009/2020; UIDP/00009/2020, FCT). 2022. Rolo, Dora; Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/8360.
  3. Nanotoxicology in Safety Assessment of Nanomaterials: Book Presentation. Presentation of the book 'Nanotoxicology in Safety Assessment of Nanomaterials' (https://link.springer.com/book/10.1007/978-3-030-88071-2): Worldwide experts present the latest knowledge on nanotoxicology Innovative approaches in synthesis/application of nanomaterials Provides central knowledge for applying safe and sustainable nanotechnologies with a safe-by-design” approach. 2022. Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/8342.
  4. Nanocellulose effects on microRNA expression in human bronchial epithelial cells. Nanocellulose is an innovative nanomaterial with physicochemical properties (high specific area, high tensile strength and stiffness, gas barrier properties, optical properties, and biodegradability) that give it potential for a wide variety of industrial (packaging, paper industry and others) and biomedical applications (regenerative medicine, wound healing, drug delivery systems and others).. Po. 2022. Ventura, Célia; Vieira, Luís; Silva, Catarina; Pinto, Fátima; Pedrosa, J.F.S.; Fernandes, S.; Raupp da Rosa, R.; et al. http://hdl.handle.net/10400.18/8361.
  5. Cell culture process. Virtual Lab video. Cell Culture Process. Virtual Lab video.. FCT/MCTES através de fundos nacionais (PIDDAC), PTDC/SAU-PUB/29481/2017, PTDC/SAU-PUB/32587/2017 e ToxOmics ( Centre for Toxicogenomics and Human Health, UIDB/00009/2020). 2021. Pinto, Fátima; Rolo, Dora; Vital, Nádia; Ventura, Célia; Moreira, Rodrigo; Cadete, João; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/8326.
  6. Aula 9: Vias de Efeitos Adversos e Avaliação de Risco. Sobre Vias de Efeitos Adversos e Avaliação de Risco.. FCT PTDC/SAU-PUB/29481/2017 – INGESTnano. 2021. Rolo, Dora; Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/8356.
  7. Transepithelial Electrical Resistance (TEER) measurement. Virtual Lab video. Transepithelial Electrical Resistance (TEER) measurement. Virtual Lab video.. FCT/MCTES através de fundos nacionais (PIDDAC), PTDC/SAU-PUB/29481/2017, PTDC/SAU-PUB/32587/2017 e ToxOmics (UIDB/00009/2020; UIDP/00009/2020, FCT).. 2021. Rolo, Dora; Pinto, Fátima; Vital, Nádia; Ventura, Célia; Moreira, Rodrigo; Cadete, João; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/8330.
  8. Princípios básicos de genotoxicidade e carcinogénese. A Toxicologia Genética estuda os efeitos adversos de xenobióticos ao nível do genoma dos organismos vivos, procurando compreender a interação gene-ambiente e suas consequências para a saúde humana. O presente curso irá proporcionar aos formandos uma introdução aos conceitos essenciais e às metodologias usadas na área da Toxicologia Genética.. Sumário: 1. Interação entre fatores ambientais e o geno. 2021. Louro, Henriqueta; Ventura, Célia; Tavares, Ana M.; Rolo, Dora; Pinto, Fátima; Silva, Maria João. http://hdl.handle.net/10400.18/8357.
  9. Cytotoxicity MTT assay. Virtual Lab video. Cytotoxicity MTT assay. Virtual Lab video.. FCT/MCTES através de fundos nacionais (PIDDAC), PTDC/SAU-PUB/29481/2017, PTDC/SAU-PUB/32587/2017 e ToxOmics ( Centre for Toxicogenomics and Human Health, UIDB/00009/2020). 2021. Pinto, Fátima; Rolo, Dora; Vital, Nádia; Ventura, Célia; Moreira, Rodrigo; Cadete, João; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/8329.
  10. Clonogenic Assay. Virtual Lab video. Clonogenic Assay. Virtual Lab video.. FCT/MCTES através de fundos nacionais (PIDDAC), PTDC/SAU-PUB/29481/2017, PTDC/SAU-PUB/32587/2017 e ToxOmics ( Centre for Toxicogenomics and Human Health, UIDB/00009/2020). 2021. Pinto, Fátima; Rolo, Dora; Vital, Nádia; Ventura, Célia; Moreira, Rodrigo; Cadete, João; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/8328.
  11. Aula 8: Efeitos celulares e genéticos dos nanomateriais ingeridos. Sobre os efeitos celulares e genéticos dos nanomateriais ingeridos.. FCT. 2021. Vital, Nádia; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/8355.
  12. Aula 5: O projeto HBM4EU - exemplo de biomonitorização da exposição ocupacional ao crómio.. O projeto HBM4EU - exemplo de biomonitorização da exposição ocupacional ao crómio.. 2021. Ana Maria, Tavares; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/8352.
  13. Aula 6: Nanomateriais - o que são, que riscos comportam. Sobre o que são e que riscos comportam os nanomateriais.. 2021. Pinto, Fátima; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/8353.
  14. Toxicologia Genética - Princípios básicos de genotoxicidade humana e ambiental. Toxicologia Genética - princípios básicos de genotoxicidade humana e ambiental:1.Interação de fatores ambientais com o genoma humano – efeitos na saúde; 2.Toxicologia Genética. Objetivos e conceitos; 3.Inter-relação entre genotoxicidade e carcinogénese; 4.Relação entre lesão do DNA, reparação, mutação e cancro.. 2020. Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/7543.
  15. Chromium (VI), nickel and polycyclic aromatic hydrocarbons and lung cancer. Problem formulation: In workplace environments the most common exposure scenario implies workers coexposure to multiple chemicals during tasks performance; Occupational exposure limits (OEL) – prevention of morbidity and mortality from exposure to individual chemical stressors in the workplace but do not account for all the complexities of the workplace environment. There is a need for occupationa. 2020. Silva, Maria João; Tavares, Ana; Louro, Henriqueta; Viegas, Susana. http://hdl.handle.net/10400.18/7564.
  16. Toxicologia Genética - Vias de Efeitos Adversos e Avaliação de Risco. Aula sobre Vias de Efeitos Adversos e Avaliação de Risco. FCT/MCTES através de fundos nacionais (PIDDAC), PTDC/SAU-PUB/29481/2017. 2020. Rolo, Dora; Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/7551.
  17. Nanomateriais - o que são, que riscos comportam. Aula 6: Nanomateriais - o que são, que riscos comportam. Nanomaterials (NM) – Materials with one or more components that have at least one dimension in the range of 1 to 100 nm. 2020. Pinto, Fátima; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/7548.
  18. Estudos de Biomonitorização Humana. Aula 4: Estudos de Biomonitorização Humana: Biomonitorização humana e Tipos de Biomarcadores; Epidemiologia Molecular; Exemplo de Aplicação: biomonitorização da exposição humana a fumo de tabaco ambiental em contexto ocupacional.. 2020. Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/7546.
  19. O projeto HBM4EU - exemplo de biomonitorização da exposição ocupacional ao crómio. Aula 5: O projeto HBM4EU - exemplo de biomonitorização da exposição ocupacional ao crómio. Projeto HBM4EU - General objective: To understand human exposure to chemicals and resulting health impacts and communicate with policy makers to ensure that the results are exploited in the design of new chemicals policies and the evaluation of existing measures.. 2020. Tavares, Ana Maria; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/7547.
  20. Nanomateriais ingeridos: efeitos celulares e genéticos. Aula sobre os efeitos celulares e genéticos dos nanomateriais ingeridos.. FCT/MCTES através de fundos nacionais (PIDDAC), PTDC/SAU-PUB/29481/2017: UID/BIM/00009/2013 (Centre for Toxicogenomics and Human Health – ToxOmics).. 2020. Vital, Nádia; Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/7550.
  21. Abordagens experimentais à avaliação do efeito genotóxico de agentes químicos e físicos. Aula 2: Abordagens experimentais à avaliação do efeito genotóxico de agentes químicos e físicos: Ensaios de longo-termo em roedores; Ensaios de curto-termo para avaliação de efeitos genotóxicos in vitro e in vivo; Linhas orientadoras para produtos farmacêuticos (ICH guidelines). 2020. Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/7544.
  22. Toxicologia Genética: material de apoio a Estágio de Curta Duração. A Toxicologia Genética estuda os efeitos adversos de xenobióticos ao nível do genoma dos organismos vivos, procurando compreender a interação gene-ambiente e suas consequências para a saúde humana. Este estágio tem como objetivo introduzir os conceitos básicos e metodologias utilizadas na área da Toxicologia Genética, no contexto da Unidade de Investigação e Desenvolvimento do Departamento de Gené. 2019. Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/7159.
  23. Departamento de Genética Humana do INSA - Grupo de Investigação em Toxicologia Genética: material de apoio a visita. Apresentação do Departamento de Genética Humana. Conceitos e metodologias básicas utilizadas em toxicologia genética. Nanotoxicologia.. PTDC/SAU-PUB/29481/2017, PTDC/SAU-PUB/32587/2017 e UID/BIM/00009/2013 (Centre for Toxicogenomics and Human Health – ToxOmics, FCT),. 2019. Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/7162.
  24. Adverse Outcome Pathways (AOPs) development, a tool for predictive nanotoxicology. Nanomaterials (NMs) have the potential to improve novel and useful wide applications in electronics, chemicals, environmental protection, biological medicine, food and others. Therefore, NMs rapid proliferation presents a dilemma to regulators regarding hazard identification, with increased concerns for public health. Predictive nanotoxicology describes a multidisciplinary approach to NMs evaluati. 2019. Rolo, Dora; Louro, Henriqueta. http://hdl.handle.net/10400.18/7051.
  25. Aula 5: Exposição Ocupacional a Nanofibras: abordagem in vitro dos efeitos genéticos e epigenéticos. Definição de nanomaterial e suas propriedades.Nanomateriais m anufaturados. Possíveis vias de exposição a NM e efeitos na saúde. Interações NM sistemas biológicos. A Nanotoxicologia. Genotoxicidade dos Nanomateriais. Estudos realizados in vitro. Estudos realizados in vivo. Estudos toxicológicos sobre exposição a nanofibras.Toxicogenómica, toxicotranscriptómica e toxicoepigenómica. Conclusões dos e. 2019. Ventura, Célia; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/7068.
  26. A predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system. Cellulose nanofibrils (CNF) have an enormous potential for industrial and biomedical applications, assuming a great economic value. Because other nanofibres, e.g. carbon nanotubes (CNT), have revealed toxicity 1,2, there is a need to comprehensively evaluate the toxic potential of CNF along the value chain, before they enter the market. This project is aimed at a safety evaluation of several CNF c. 2019. Ventura, Célia; Teixeira, Sara; Louro, Henriqueta; Lourenço, Ana Filipa; Ferreira, Paulo J.T.; Silva, Maria João. http://hdl.handle.net/10400.18/7052.
  27. Performance and impact of HBM4EU, how to evaluate?. HBM4EU is a joint effort of 28 countries, the European Environment Agency and the European Commission, co-funded under Horizon 2020. The initiative is coordinating and advancing human biomonitoring in Europe. HBM4EU is generating evidence of the actual exposure of citizens to chemicals and the possible health effects in order to support policy making. The HBM4EU initiative represents a novel colla. 2018. Reynders, Hans; Campenhout, Karen Van; Louro, Henriqueta; Silva, Maria João; Isidro, Glória; Colles, Ann. http://hdl.handle.net/10400.18/5939.
  28. Aula 1: Toxicologia Genética. 1. Introdução à Toxicologia Genética. Objectivos gerais 2. Interação de fatores ambientais com o genoma humano – efeitos na saúde 3. Da genotoxicidade à carcinogénese 4. Mecanismos moleculares de mutagénese 4.1. Relação entre lesão do DNA, reparação, mutação e cancro. 2018. Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/5989.
  29. Aula 3: Métodos de avaliação de efeitos genotóxicos e suas aplicações.. 1. Enquadramento da Experimentação Animal em Toxicologia Genética 2. Aplicações de modelos de ratinhos transgénicos 3. Construção de um ratinho transgénico 4. Modelos de ratinhos transgénicos para estudos de genotoxicidade 5. O ratinho transgénico baseado em plasmideo contendo o gene LacZ 6. Exemplos de Aplicações dos Modelos de ratinhos transgénicos 7. Ratinhos geneticamente modificados para ensa. 2018. Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/5991.
  30. Aula 4: Estudos de Biomonitorização Humana. 1. Biomonitorização humana e Tipos de Biomarcadores 2. Exemplo de Aplicação: biomonitorização da exposição humana a fumo de tabaco ambiental em contexto ocupacional 3. A Iniciativa Europeia de Biomonitorização (HBM4EU) 4. Conclusões. 2018. Louro, Henriqueta; Silva, Maria Joao. http://hdl.handle.net/10400.18/5992.
  31. Investigação da Segurança dos Nanomateriais. Comunicação sobre a investigação da Segurança dos Nanomateriais.. 2018. Louro, Henriqueta; Ventura, Célia; Silva, Maria João. http://hdl.handle.net/10400.18/6221.
  32. Efeitos genéticos e epigenéticos da exposição a nanomateriais. Sumário: Definição de nanomaterial e suas propriedades; Nanomateriais Manufaturados – NM; Possíveis vias de exposição a NM e efeitos na saúde; Interações NM - sistemas biológicos; A Nanotoxicologia; Genotoxicidade dos Nanomateriais; Estudos realizados In vitro; Estudos realizados In vivo; Estudos efectuados sobre exposição ocupacional a nanofibras; Toxicogenómica, toxicotranscriptómica e toxicoepi. 2018. Ventura, Célia; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/5918.
  33. Exposição ocupacional a nanofibras por via respiratória e potencial impacto na saúde. Com a generalização da produção e incorporação de nanofibras em diversos produtos para consumo humano, prevê-se o aumento considerável da exposição humana a estes nanomateriais, particularmente em contexto ocupacional. Isto intensifica a preocupação de que as propriedades singulares das nanofibras possam conduzir a efeitos nefastos no organismo. De facto, estudos anteriores sobre aerossóis ultrafi. 2017. Ventura, Célia; Louro, Henriqueta; Sousa-Uva, António; Silva, Maria João. http://hdl.handle.net/10400.18/4769.
  34. Efeitos tóxicos dos nanotubos de carbono em células do trato respiratório humano. Os nanotubos de carbono de parede múltipla (NTCs) são nanomateriais (NM) frequentemente utilizados como compósitos estruturais, em aplicações energéticas e em eletrónica. Com o objetivo de contribuir para a avaliação da sua segurança para o homem, foi investigada a toxicidade de vários NTC (NM-400, NM-401, NM-402 e NM-403) considerando a relação entre as suas propriedades físico-químicas e toxicol. 2017. Louro, Henriqueta; Pinhão, Mariana; Santos, Joana; Tavares, Ana; Vital, Nádia; Ventura, Célia; Silva, Maria João. http://hdl.handle.net/10400.18/4770.
  35. Departamento de Genética Humana do INSA: actividades de investigação e desenvolvimento em toxicologia genética. Apresentação do Departamento de Genética Humana a estudantes do secundário, com enfoque nas actividades de investigação e desenvolvimento em toxicologia genética.. 2017. Louro, Henriqueta. http://hdl.handle.net/10400.18/5013.
  36. Toxicologia e Saúde: Toxicologia Genética - I. 1. Introdução à Toxicologia Genética. Objectivos gerais 2. Interação de fatores ambientais com o genoma humano – efeitos na saúde 3. Da genotoxicidade à carcinogénese 4. Mecanismos moleculares de mutagénese 4.1. Relação entre lesão do DNA, reparação, mutação e cancro. 2017. Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/5155.
  37. Toxicologia e Saúde: Toxicologia Genética - II. Métodos de avaliação de efeitos genotóxicos e suas aplicações: • Ensaios de genotoxicidade de longo-termo • Ensaios de genotoxicidade de curto-termo, in vitro. 2017. Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/5156.
  38. O ensaio do cometa e o ensaio do micronúcleo. Esquemas-síntese das metodologias utilizadas no Ensaio do Cometa e do Micronúcleo no contexto da Toxicologia Genética.. 2016. Louro, Henriqueta; Silva, Maria. http://hdl.handle.net/10400.18/3812.
  39. Evaluation of the cytotoxic and genotoxic effects of benchmark multi-walled carbon nanotubes in relation to their physicochemical properties. To contribute with scientific evidence to the grouping strategy for the safety assessment of multi-walled carbon nanotubes (MWCNTs), this work describes the investigation of the cytotoxic and genotoxic effects of four benchmark MWCNTs in relation to their physicochemical characteristics, using two types of human respiratory cells. The cytotoxic effects were analysed using the clonogenic assay and. 2016. Louro, Henriqueta; Pinhão, Mariana; Santos, Joana; Tavares, Ana; Vital, Nádia; Silva, Maria João. http://hdl.handle.net/10400.18/4046.
    10.1016/j.toxlet.2016.09.016
  40. Departamento de Genética Humana do INSA e as suas atividades: apresentação no âmbito de uma visita de estudo do ensino secundário. Apresentação das actividades realizadas no Departamento de Genética Humana com particular destaque para a investigação desenvolvida pelo grupo de Toxicologia Genética. Introdução à visita dos alunos aos laboratórios de genética.. 2016. Louro, Henriqueta. http://hdl.handle.net/10400.18/3813.
  41. Riscos laborais associados à manipulação de nanomateriais. De um modo geral, os nanomateriais manufaturados (NM) são definidos como materiais fabricados deliberadamente e que contêm partículas com pelo menos uma dimensão externa na gama de tamanhos compreendida entre 1 e 100 nanómetros (Comissão Europeia, 2011). A sua pequena dimensão confere-lhes propriedades físicas, químicas e biológicas que podem diferir bastante das propriedades dos materiais com a m. 2016. Louro, Henriqueta. http://hdl.handle.net/10400.18/3833.
  42. Challenges in the safety assessment of nanomaterials: the contribution of physicochemical characterization. 2016. Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/4612.
  43. Relevance of physicochemical characterization in nanotoxicology studies. Nanomaterials (NMs) with the same chemistry can greatly differ by size, surface area, shape, stability, rigidness, coating or electrical charge and these characteristics affect nano-bio interactions, leading to different toxic potential. In this communication is shown that closely related NMs can have different genotoxic effects, evidencing the importance of investigating the toxic potential of ea. 2016. Louro, Henriqueta; Tavares, Ana; Pinhão, Mariana; Santos, Joana; Silva, M.J.. http://hdl.handle.net/10400.18/3816.
  44. Manufactured Nanomaterials: is there a correlation between toxicological effects and the physicochemical properties?. Toxicological information on nanomaterials (NMs) is of major importance for safety assessment, since they are already used in many consumer products and promise cutting-edge applications in the future. While the number of different NMs increases exponentially, new strategies for risk assessment are needed to cope with the safety issues, keeping pace with innovation. However, recent studies have su. 2016. Louro, Henriqueta; Tavares, Ana; Pinhão, Mariana; Santos, Joana; Vital, Nádia; Silva, Maria João. http://hdl.handle.net/10400.18/3917.
  45. Nanomateriais manufaturados – um risco para a saúde dos trabalhadores?. Introdução: Existem diversas definições de nanomateriais manufaturados (NM) embora, de um modo geral, estes sejam definidos como materiais fabricados deliberadamente e que contêm partículas com pelo menos uma dimensão externa na gama de tamanhos compreendida entre 1 e 100 nanómetros (Comissão Europeia, 2011). Esta pequena dimensão confere-lhes propriedades físicas, químicas e biológicas que podem. 2015. Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/3177.
  46. Moving towards a safe by design approach for ENM: linking ENM relevant properties to toxicological concerns. Within the Safe by Design concept, the functionality of a material and its toxicity are considered in an integrated way. The central goal of this presentation is to discuss some fundamental principles of engineered nanomaterials (ENM) interactions with biological systems relevant to human exposure and biological responses. Major factors to consider in the ENM safe-by-design approach are surface mo. 2015. Borges, Teresa; Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/3414.
    10.1016/j.toxlet.2015.08.095
  47. Evaluation of combined cytotoxic effects of effects of ochratoxin A and fumonisina B1 in human liver and renal cells. Mycotoxins are fungal food contaminants with potential to cause severe acute and chronic conditions1. Therefore, food contamination with mycotoxins such as ochratoxin A (OTA) and fumonisin B1 (FB1) causes great concern. Previous studies addressed the co-occurrence of these toxins in foods2, however there is little knowledge on their combined cytotoxic effects. In the present study we aimed to eval. 2015. Tavares, A.M.; Mendonça, I.; Alvito, Paula; Loureiro, S.; Louro, Henriqueta; Silva, Maria. http://hdl.handle.net/10400.18/3073.
  48. Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 1: Oral route. Synthetic amorphous silica (SAS) in its nanosized form is now used in food applications although the potential risks for human health have not been evaluated. In this study, genotoxicity and oxidative DNA damage of two pyrogenic (NM-202 and 203) and two precipitated (NM-200 and -201) nanosized SAS were investigated in vivo in rats following oral exposure. Male Sprague Dawley rats were exposed to 5. 2015. Tarantini, Adeline; Huet, Sylvie; Jarry, Gérard; Martine, Poul; Tavares, Ana; Vital, Nádia; Louro, Henriqueta; Silva, Maria João; Fessard, Valérie. http://hdl.handle.net/10400.18/3089.
    10.1002/em.21935
  49. Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: an integrative approach of complementary endpoints. Ochratoxin A (OTA) is a well-known nephrotoxic and potential carcinogenic agent but no consensus about the molecular mechanisms underlying its deleterious effects has been reached yet. The aim of this study is to integrate several endpoints concerning OTA-induced toxicological effects in Vero kidney cells in order to obtain additional mechanistic data, especially regarding the influence of reactiv. 2015. Costa, J.G.; Saraiva, N.; Guerreiro, P.S.; Louro, Henriqueta; Silva, Maria João; Miranda, J.P.; Castro, M.; et al. http://hdl.handle.net/10400.18/3430.
    10.1016/j.fct.2015.11.018.
  50. Apresentação sobre o Departamento de Genética Humana. Apresentação sobre o Departamento de Genética Humana do Instituto Nacional de Saúde Doutor Ricardo Jorge (história, orgância, atividades) e em particular das suas Unidades de investigação.. 2015. Louro, Henriqueta. http://hdl.handle.net/10400.18/3388.
  51. Avaliação do potencial citotóxico e genotóxico de contaminantes de sedimentos do Estuário do Sado numa linha celular humana. O presente estudo integra-se num projeto mais amplo que visa avaliar o risco ambiental – que inclui os riscos ecológicos e para a saúde humana - associado a este ambiente estuarino contaminado. Em particular, este estudo teve como objetivo caracterizar o potencial citotóxico e genotóxico de sedimentos colhidos em vários locais de pesca do Estuário do Sado numa linha celular humana, tendo em vista. 2014. Pinto, Miguel; Costa, Pedro M.; Louro, Henriqueta; Costa, Maria Helena; Lavinha, João; Caeiro, Sandra; Silva, Maria João; Costa, Pedro Manuel. http://hdl.handle.net/10400.2/3724.
  52. Avaliação integrada dos efeitos genotóxicos de nanomateriais manufaturados no ratinho transgénico LacZ. Num estudo recente, demonstrámos que um nanomaterial de dióxido de titânio na forma cristalina designada anatase, o NM-102 (do repositório do Joint Research Center; Ispra, Itália), induziu um aumento significativo de quebras cromossómicas - detetáveis na forma de micronúcleos - em linfócitos humanos expostos ex vivo(3) não se tendo, porém, observado um efeito dose-resposta. No sentido de prossegui. 2014. Louro, Henriqueta; Tavares, Ana; Vital, Nádia; Costa, Pedro M.; Alverca, Elsa; Lavinha, João; Silva, Maria João. http://hdl.handle.net/10400.18/2544.
  53. Genotoxicity of Microcystin-LR in In Vitro and In Vivo Experimental Models. Microcystin-LR (MCLR) is a cyanobacterial toxin known for its acute hepatotoxicity. Despite being recognized as tumour promoter, its genotoxicity is far from being completely clarified, particularly in organs other than liver. In this work, we used the comet and/or the micronucleus (MN) assays to study the genotoxicity of MCLR in kidney- (Vero-E6) and liver-derived (HepG2) cell lines and in blood. 2014. Dias, Elsa; Louro, Henriqueta; Pinto, Miguel; Santos, Telma; Antunes, Susana; Pereira, Paulo; Silva, Maria João; et al. http://hdl.handle.net/10400.18/2720.
    Biomed Res Int. 2014;2014:949521. doi: 10.1155/2014/949521. Epub 2014 May 18
  54. Impacto das nanotecnologias na saúde publica. 2014. Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/2306.
  55. Nanotoxicologia: contribuição para a avaliação da segurança dos nanomateriais. Os NMs têm propriedades físico-químicas específicas, que condicionam (a sua reatividade, melhorando as propriedades mecânicas, óticas, elétricas, magnéticas. Porém a sua toxicidade deve ser considerada.. 2014. Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/2304.
  56. Nanotecnologias: benefícios e potenciais riscos para a saúde humana. A nanomedicina usa NMs para o diagnóstico, prevenção e tratamento da doença e para melhor compreender a patofisiologia da doença.. 2014. Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/2303.
  57. Métodos de avaliação de efeitos genotóxicos e suas aplicações. Conteúdo da Aula: -Toxicologia Genética -Enquadramento da Experimentação Animal em Toxicologia Genética -Aplicações de modelos de ratinhos transgénicos -Construção de um ratinho transgénico -Modelos de ratinhos transgénicos para estudos de genotoxicidade -O ratinho transgénico baseado em plasmideo contendo o gene LacZ -Exemplos de Aplicações dos Modelos de ratinhos transgénicos -Ratinhos geneticam. 2014. Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/2319.
  58. Estudos de biomonitorização humana: exemplo de aplicação prática. Aplicação prática ao estudo do efeito do fumo de tabaco ambiental em estabelecimentos de restauração de Lisboa.. 2014. Silva, Maria João; Louro, Henriqueta. http://hdl.handle.net/10400.18/2315.
  59. Case study: Multi-mycotoxin determination in baby foods and in vitro combined cytotoxic effects of aflatoxin M1 and ochratoxin A. 2014. Tavares, Ana; Louro, Henriqueta; Silva, Louro. http://hdl.handle.net/10400.18/2317.
  60. Projeto HERA - Avaliação do potencial genotóxico de sedimentos dum ambiente estuarino contaminado. Estudo de caso: Avaliação do potencial genotóxico de sedimentos dum ambiente estuarino contaminado.. 2014. Pinto, Miguel; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/2305.
  61. Nanomateriais manufaturados: novos desafios para a saúde. Os nanomateriais manufaturados (NM)apresentam propriedades físico-químicas específicas que lhes conferem caraterísticas mecânicas, óticas, elétricas e magnéticas únicas e vantajosas para aplicações industriais e biomédicas. Contudo, o desenvolvimento exponencial das nanotecnologias contrasta com a ainda insuficiente avaliação de risco para a saúde humana e para o ambiente, conduzindo a preocupaçõe. 2013. Louro, Henriqueta; Borges, Teresa; Silva, Maria João; Tavares, Ana; Vital, Nádia; Antunes, Susana; Lavinha, João. http://hdl.handle.net/10400.18/1970.
    0870-9025http://dx.doi.org/10.1016/j.rpsp.2012.12.004
  62. Nanotecnologias e saúde pública. Os nanomateriais manufaturados (NMs), isto é, fabricados deliberadamente para fins específicos, apresentam propriedades físico-químicas únicas (e.g., dimensão, área superficial, funcionalização) que lhes conferem caraterísticas mecânicas, óticas, elétricas e magnéticas muito vantajosas para aplicações industriais e biomédicas. Efetivamente depositam-se grandes expetativas nas tecnologias baseadas. 2013. Louro, Henriqueta; Tavares, Ana; Leite, Ema; Silva, Maria João. http://hdl.handle.net/10400.18/1973.
  63. Estudos da toxicidade de misturas de aflatoxina M1 e ocratoxina A numa linha celular humana. 2013. Tavares, Ana Maria; Alvito, Paula; Loureiro, Susana; Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/2116.
  64. Caracterização da genotoxicidade de nanomateriais manufaturados e potencial impacto na saúde humana. Os nanomateriais manufaturados (NMs), isto é, materiais fabricados que contêm partículas em que uma ou mais dimensões externas se situam na gama de tamanhos compreendidos entre 1 nanómetro e 100 nanómetros1 apresentam propriedades físico-químicas únicas (e.g., dimensão, área superficial, funcionalização) que lhes conferem caraterísticas mecânicas, óticas, elétricas e magnéticas muito vantajosas, r. 2013. Louro, Henriqueta; Tavares, Ana; Antunes, Susana; Vital, Nádia; Lavinha, João; Silva, Maria João. http://hdl.handle.net/10400.18/1539.
  65. Human exposure to indoor radon: a survey in the region of Guarda. Radon ((222)Rn) is a radioactive gas, abundant in granitic areas, such as the city of Guarda at the northeast of Portugal. This gas is recognised as a carcinogenic agent, being appointed by the World Health Organization as the second leading cause of lung cancer after tobacco smoke. Therefore, the knowledge of radon concentrations inside the houses (where people stay longer) is important from the. 2013. Louro, Alina; Peralta, Luis; Soares, S.; Pereira, A.; Cunha, G.; Belchior, A.; Ferreira, L.; et al. http://hdl.handle.net/10400.18/1127.
    doi: 10.1093/rpd/ncs166
  66. Formação de subprodutos de desinfeção da água e avaliação do seu potencial genotóxico: o caso dos hidrocarbonetos aromáticos policíclicos. 2013. Pinto, Miguel; Rebola, Marlene; Louro, Henriqueta; Antunes, Alexandra M.M.; José, Sílvia S.; Rocha, M. Raquel; Silva, M. João; Cardoso, Ana Sofia. http://hdl.handle.net/10400.18/2127.
  67. Effects of occupational exposure to tobacco smoke: is there a link between environmental exposure and disease?. In a previous study, evidence was provided that indoor secondhand tobacco smoke (SHS) air pollution remains high in Lisbon restaurants where smoking is allowed, regardless of the protective measures used. The aim of this study was to determine in these locations the levels of polycyclic aromatic hydrocarbons (PAH) associated with the particulate phase of SHS (PPAH), a fraction that contains recogn. 2013. Pacheco, Solange A.; Torres, Vukosava M.; Louro, Henriqueta; Gomes, Filomena; Lopes, Carlos; Marçal, Nelson; Fragoso, Elsa; et al. http://hdl.handle.net/10400.18/1735.
    doi: 10.1080/15287394.2013.757269
  68. Genotoxicidade ambiental: identificar os perigos para prevenir a doença. No âmbito do Dia do Departamento de Genética Humana (DGH) do INSA, são apresentadas as atividades do grupo de investigação em toxicologia genética do DGH, com enfoque nas interações genoma-ambiente e suas consequências para a saúde.. 2013. Louro, Henriqueta; Silva, Maria João. http://hdl.handle.net/10400.18/1783.
  69. Nanomateriais Manufaturados: avaliação de efeitos genotóxicos e implicações para saúde pública. A exposição da população humana a partículas exógenas de dimensões da ordem dos nanómetros, os nanomateriais, pode ser considerada ubiquitária: tais partículas encontram-se no ambiente, em consequência da ocorrência natural e antropogénica, mas também nos produtos que consumimos diariamente. Os nanomateriais manufaturados (NMs), isto é, fabricados deliberadamente, apresentam propriedades físico-qu. 2013. Louro, Henriqueta; Tavares, Ana; Vital, Nádia; Antunes, Susana; Lavinha, João; Silva, Maria João. http://hdl.handle.net/10400.18/1765.
  70. Contaminantes da água com potencial genotóxico: cianotoxinas e subprodutos de desinfeção da água. A garantia da qualidade da água destinada ao consumo humano é, atualmente, uma preocupação universal, em termos de saúde pública. Assim, a presença de contaminantes de natureza microbiológica ou química, pode constituir um perigo para a saúde humana que importa avaliar, particularmente no que diz respeito a efeitos carcinogénicos. O presente trabalho representa uma abordagem multidisciplinar, abra. 2012. Dias, Elsa; Cardoso, Ana Sofia; Louro, Henriqueta; Santos, Telma; Rebola, Marlene; Pinto, Miguel; Santos, Sílvia; et al. http://hdl.handle.net/10400.18/1128.
  71. Poly (ADP-ribose) polymerase-1 deficiency does not affect ethylnitrosourea mutagenicity in liver and testis of lacZ transgenic mice. Poly (ADP-ribose) polymerase-1 (Parp1) has been implicated in DNA base excision repair, single- and double-strand break repair pathways, as well as in cell death by apoptosis or necrosis. We used Parp1(-/-) lacZ plasmid-based transgenic mice to investigate whether Parp1 deficiency influences the in vivo mutagenic and clastogenic response to the alkylating agent N-ethyl-N-Nitrosourea (ENU) in somat. 2010. Louro, Henriqueta; Faustino, Inês; Dias, Anabela; Boavida, Maria G.. http://hdl.handle.net/10400.18/131.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/04/11 Epigenetic tools in nanosafety- studying the impact of ingested nanomaterials on DNA methylation profiles of intestinal cells. International Forum on Toxicology and Pharmacology (TOXIFORUM). 11-13 April
ToxiForum (Munich, Germany)
2021/06/16 Changes in the human genome and epigenome induced by nanomaterials 5th International Congress of CiiEM (IC CiiEM)
Egas Moniz’ University Campus in Monte de Caparica, Almada
2021/04/20 Titanium dioxide nanomaterials - induced DNA damage in intestinal cells following simulated in vitro digestion. NANOTOX 2021- 10th International Conference on Nanotoxicology, virtual meeting
(Braga)
2020/12/07 The need for early-stage safety assessment in the development of nanomaterials – the role of nanotoxicology. 6th NanoBoston Conference (Virtual)
(Boston, United States)
2020/09/12 Analysis Of The Cytotoxicity And Genotoxicity of Digested Titanium Dioxide Nanomaterials (TiO2) In Intestinal Cells EMGS 2020 - Environmental Mutagenesis & Genomics Society Virtual Annual Meeting
Environmental Mutagenesis & Genomics Society (United States)
2020/01/20 Nano-bio interactions of titanium dioxide nanomaterials in the intestinal moiety after simulated digestion in vitro. IVth International Caparica Symposium on Nanoparticles, Nanomaterials and Applications 2020 (ISN2A)
(Lisboa, Portugal)
2019/11/25 Cellular and molecular mechanisms of toxicity of ingested nanomaterials. Workshop Nanotoxicology in the context of the safety assessment of nanomaterials, INSA, 25 de Novembro de 2019, Lisboa Workshop Nanotoxicology in the context of the safety assessment of nanomaterials,
INSA (Lisboa, Portugal)
2019/11/25 Cellular and molecular mechanisms of toxicity of ingested nanomaterials. Workshop Nanotoxicology in the context of the safety assessment of nanomaterial Cellular and molecular mechanisms of toxicity of ingested nanomaterials. Workshop Nanotoxicology in the context of the safety assessment of nanomaterial
Instituto Nacional de Saúde Doutor Ricardo Jorge (Lisboa, Portugal)
2019/10/28 Nanotoxicology research at INSA- do NMs contribute for genotoxic effects that may lead to cancer? Jornadas ToxOmics
INSA
2019/08/25 Evaluation of the cytotoxicity and genotoxicity of ingested titanium dioxide nanomaterials in intestinal cells. 19th ISTA International Symposium on Toxicity Assessment, ISTA2019
(Salónica, Greece)
2018/07/04 Henriqueta Louro, Ana Luísa Vasconcelos, Deborah Penque, Maria João Silva. Human biomonitoring studies contribution for better public health decisions. Ciência 2018 - Encontro de Ciência e Tecnologia em Portugal.
Ministério da Ciência e Tecnologia (Lisboa, Portugal)
2017/11/27 Tackling the uncertainties of emergent nanomaterials for public health: are metal nanoparticles hazardous pollutants? 2nd International Conference on Pollutant Toxic Ions and Molecules, PTIM2017, Caparica, Novembro 2017
2016/05 Riscos laborais associados à manipulação de nanomateriais Seminário Saúde e Segurança do Trabalho: promover locais de trabalho saudáveis ao longo da vida
Instituto Nacional de Saúde Doutor Ricardo Jorge (Lisboa, Portugal)
2016/04/19 Challenges in the safety assessment of nanomaterials - the contribution of physicochemical characterization Workshop Bionanosystems Characterization
Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (Lisboa, Portugal)
2016/04/08 Relevance of physicochemical characterization in nanotoxicology studies Trends in Nanobioparticles Characterization
Instituto Nacional de Saúde Doutor Ricardo Jorge (Lisboa, Portugal)
2015/09 Moving towards a safe by design approach for ENM: linking ENM relevant properties to toxicological concerns 51st Congress of the European Societies of Toxicology (Eurotox): Bridging Sciences for Safety
(Porto, Portugal)
2014/04/03 Are standard genotoxicity tests useful for the safety evaluation of nanomaterials? 1st National Meeting on Nanotechnology: Legislate to Compete
(Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020/11 - Current Toxicological profile of cellulose nanomaterials in human gastrointestinal cells
Supervisor
 Doutoramento em Biomedicina (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/09 - 2024/10 Characterization Of Cytotoxic and Mutagenic Effects of Cellulose Nanomaterials Using In Vitro Models.
Supervisor
 Biotechnology (Master)
Universidade Nova de Lisboa Departamento de Química, Portugal
2020 - 2022 Cellular effects of nanoparticles or nanofibres
Co-supervisor
 Mestrado em Bioquímica
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020 - 2021 Avaliação de efeitos genotóxicos dos nanomateriais de dióxido de titânio em células intestinais
Supervisor
 Mestrado em Biologia Humana e Ambiente (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 - 2020 Cellular Mechanisms of Toxicity of Ingested Nanomaterials
Supervisor
 Mestrado em Biotecnologia (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019 Assessment of the cellular effects of ingested titanium dioxide nanomaterials in intestinal cells
Supervisor
 Mestrado em Biotecnologia
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019 Occupational exposure to hexavalent chromium: biomarkers of genotoxicity in human peripheral blood
Co-supervisor
 Mestrado em Bioquímica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019 Biological effects of cellulose nanofibrils in a lung epithelial cell line
Co-supervisor
 Mestrado em Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/07 - 2018/09 Contribution to biomonitoring of a non-phthalate plasticizer: analysis of biomarkers of genotoxic effects of DINCH in human cells
Supervisor
 Mestrado em Biologia Humana e Ambiente (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2016 Cyto- and Genotoxicity Assessment of Manufactured Nanomaterials in the A549 Cell Line
Co-supervisor
 Mestrado em Biotecnologia (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015 Nanotoxicology: study of nanomaterials’ genotoxic effects in cell lines
Supervisor
 Mestrado em Biologia Humana e Ambiente (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/11/25 - Current Workshop: Nanotoxicology in the context of the safety assessment of nanomaterials (2019/11/25)
Workshop (President of the Organising Committee)
2018/11/18 - Current 3rd Workshop on Human BioMonitoring in Portugal (3rd HBM-PT) (2018/11/18 - 2018/11/18)
Workshop (Member of the Scientific Committee)
 Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Fundação para a Ciência e Tecnologia, Portugal

Agência Portuguesa do Ambiente, Portugal
2014/04/03 - Current 1st NATIONAL MEETING “Nanotechnology: Regulate to compete”, IPQ, Caparica 3 april 2014 (2017/04/03)
Conference (Member of the Organising Committee)
2018 - 2018 Scientific and Organizing Committee of the 1st Workshop on Human Biomonitoring in Portugal (1st HBM-PT) - Bridging Chemical Exposure to Human Health, 2018 (2018/11 - 2018/11)
Workshop (Member of the Scientific Committee)
 Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2017/03/22 - 2017/03/25 Youth Committes of the 7th European Conference on Tobacco or Health (ECToH), Porto, Portugal, 22-25 March 2017. (2017/03/22)
Congress (Other)
2015/05/19 - 2015/05/21 NANoREG 5th Consortium Meeting and the NANoREG Pre-meeting from 19-21 May 2015 in Lisbon, Portugal (2015/05/19 - 2015/05/22)
Conference (Co-organisor)
 Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2015/04/13 - 2015/04/14 International Conference on Food Contaminants: challenges in chemical mixtures (ICFC2015) (2015/04/13 - 2015/04/14)
Conference (Member of the Organising Committee)
 Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/12/06 Arguente da dissertação de Mestrado em Regulação e Avaliação do Medicamento e Produtos de Saúde da requerida pela Licenciada . “Regulatory framework for nanotechnology in medical devices”, 6 de dezembro de 2023 (19 valores), Faculdade de Farmácia da Universidade de Lisboa
(Thesis) Arguer
 Edite Margarida Bagulho Pereira Esteves (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/04/12 Efeitos da Aflatoxina B1 nos Modelos de Culturas e Coculturas Celulares Caco-2 e Caco-2/HT29-MTX-E12
(Thesis) Arguer
 Inês Belchior Serrenho (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/12/20 Decision-tree integrated in a Safe-by-Design context for regulatory decision-making on titanium dioxide nanomaterials”, Rita Santos, 20 de dezembro de 2022.
(Thesis) Arguer
 Rita Santos (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/01 Cellular Mechanisms of Toxicity of Ingested Nanomaterials
Supervisor
 Adriana Isabel Ramos Vieira (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/11 Assessment of the cellular effects of ingested titanium dioxide nanomaterials in intestinal cells
Supervisor
 Ana Catarina Rodrigues Gramacho (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 Contribution to biomonitoring of a non-phthalate plasticizer: analysis of biomarkers of genotoxic effects of DINCH in human cells
Supervisor
 Ana Luísa Teixeira Franco Vasconcelos (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2015 Nanotoxicology: study of nanomaterials’genotoxic effects in cell lines
Supervisor
 Joana Sofia Silva Santos (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Association member

Society Organization name Role
2015 - Current EEMGS - European Environmental Mutagenesis and Genomics Society Membro
2015 - Current PToNANO- parceria para a nanotecnologia estabelecida entre o Instituto da Soldadura e Qualidade, o Instituto Nacional de Saúde Doutor Ricardo Jorge, I.P., o Instituto Português da Qualidade, I.P., e a Direção-Geral da Saúde. Membro
2010 - Current ApTox - Associação Portuguesa de Toxicologia. Membro
2000 - Current Pró-INSA – Associação para a Promoção da Investigação em Saúde Membro

Committee member

Activity description
Role 		Institution / Organization
2024/07/01 - Current Food Additives and Flavourings Panel
Member
 European Food Safety Authority, Italy
2024/01 - Current Scientific Commission for consumer safety- Working Group on nano (external expert)
Member
 Scientific Comission for Consumer Safety (SCCS) - European Commission, Luxembourg
2023/04 - Current Working Group - Working Group (WG) on New Approach Methodologies (NAMs) of the European Food Safety Authority (EFSA) (external expert).
Member
 European Food Safety Authority, Italy
2023/01 - Current Scientific Commission for consumer safety- Working Group on cosmetic ingredients (external expert)
Member
 Scientific Comission for Consumer Safety (SCCS) - European Commission, Luxembourg
2023/01 - Current Working Group - SCER Unit - Working Group Cross-cutting nanotechnologies of the European Food Safety Authority (EFSA) (external expert)
Member
 European Food Safety Authority, Italy
2022/10 - Current Nominated expert for the OECD project Using Adverse Outcome Pathways (AOP) to address combined exposures to chemicals with relevant effect-biomarkers.
Advisor / Consultant
 OECD, France
2022/01 - Current Working Group - SCER Unit - Working Group Cross-cutting genotoxicity of the European Food Safety Authority (EFSA) (external expert).
Member
 European Food Safety Authority, Italy
2018 - Current International Society for exposure science-European (ISES Europe) - Exposure data production: Human data: working group
Member
2017 - 2025 Expert on the Joint FAO/WHO Expert Committee on Food Additives (JECFA) 2017-2021 and 2021-2025 JECFA is an international scientific expert committee administered jointly by the Food and Agriculture Organization of the United Nations (FAO) and WHO.
Member
 JECFA - Joint FAO/WHO Expert Committee on Food Additives , Switzerland
2022/01 - 2024/12/30 Working Group on Toxicology of the Scientific Panel on Additives and Products or Substances used in Animal Feed (FEEDAP Panel)
Member
 European Food Safety Authority, Italy
2023 - 2024/06/30 The International Agency for Research on Cancer (IARC) Working Group to develop Volume 136 of the IARC Monographs on the carcinogenicity of Talc and Acrylonitrile
Member
 International Agency for Research on Cancer, France
2015 - 2022 Portuguese ISO/CEN Technical Commission for Nanotechnologies (CT194)
Member
 Instituto Português da Qualidade, Portugal

Conference scientific committee

Conference name Conference host
2019/11/25 - Current Workshop Nanotoxicology in the context of the safety assessment of nanomaterials INSA, Lisbon
2013/11/15 - Current International Conference on Tobbaco Prevention and Control, ICTPC’13 Lisboa, 15 de Novembro.
2020/12/07 - 2020/12/09 6th NanoBoston Conference (Virtual), 7-9 December 2020 Virtual
2020/11/18 - 2020/11/18 3rd Workshop on Human BioMonitoring in Portugal (3rd HBM-PT) Virtual

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2007 - 2020 Toxicology and Health/Toxicologia e Saúde Mestrado em Biologia Humana e Ambiente /MsC in Human and Environment Biology (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2009 - 2009 Actualização em Toxicologia Genética e Toxicogenómica (Módulo III – Modelos murinos transgénicos para estudos de mutagénese e cancerigénese), Actualização em Toxicologia Genética e Toxicogenómica Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022/05/01 - 2022/06/30 Reviewer for European Health and Digital Executive Agency (HADEA) for the evaluation of the proposal(s) submitted in response to the call HORIZON-HLTH-2022, ECAS HORIZON-MISS-2021-CANCER-02-03; Evaluation of 5 projects
Evaluator
 European Health and Digital Executive Agency

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current Food Research International
2020 - Current Frontiers in Bioengineering and Biotechnology Frontiers
2020 - Current Journal of Toxicology and Environmental Health, Part A Taylor and Francis
2019 - Current Environmental Research Elsevier
2018 - Current Nanoscience (specialty section of Frontiers in Chemistry) Frontiers
2018 - Current Frontiers in Chemistry Frontiers
2018 - Current International Journal of Nanomedicine Dove Press
2017 - Current Genetics and Molecular Research GMR
2016 - Current Biotechnic & Histochemistry Taylor and Francis
2016 - Current Toxicology Reports Elsevier
2008 - Current Mutation Research
2008 - Current BioEssays John Wiley & Sons
2021/05 - 2021/12 International Journal of Hygiene and Environmental Health Science Direct
2021 - 2021 Journal of Hazardous Materials Elsevier

Other jury / evaluation

Activity description Institution / Organization
2020/02 - 2020/12 Reviewer of project proposals for the Latvian Council of Science Project Evaluation System (2020) Latvijas Zinatnes Padome, Latvia
2014 - 2014 Reviewer of Project Proposals for Belgian Foundation against Cancer La Fondation contre le Cancer / Belgian Foundation against Cancer , Belgium
Distinctions

Other distinction

2013 Best poster communication
2012 Best oral communication at International Conference on Environmental Health 2012 (co-author)
2008 Prémio para melhor poster
2005 Prémio para melhor poster científico