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I completed a PhD in Biological Sciences (2009) at the Centre for Environmental & Molecular Biology (UMinho), assessing the pharmacological targets of newly synthesized phenolic imidazole derivatives and their potential as antioxidants for oxidative stress-related disorders. As a Post-Doctoral fellow (2010-2016), I merged my Molecular Biology expertise with Biotechnology tools to explore the molecular properties of antimicrobial peptides as potential therapeutics for burn wound healing and tuberculosis, having worked at the Centre of Biological Engineering (UMinho, PT), UC Riverside (USA) and Univ Medical Centre of Groningen (NL). These original studies, published in 5% of top-ranked journals, led to the filing of a PCT patent (WO2017098474A1) and awarded an Honor Mention in the 2016 Bluepharma/UCoimbra Innovation Award. Driven by addressing prevailing medical and societal challenges, and progressing my career, I moved (2016) to UCIBIO-REQUIMTE (UPorto). Currently, I am an Assistant Researcher (contract under Scientific Employment Stimulus, CEEC), working on assessing the 1) Developmental neurotoxicity of New Psychoactive Substances, namely synthetic cannabinoids (SCs); 2) Epigenetic impact of Substances of Abuse on neurotoxicological mechanisms; 3) Role of Substances of Abuse on accelerated cell senescence and aging; 4) Molecular mechanisms underlying the onset of mood and cognitive adverse events induced by pharmaceuticals. The main findings supported a Critical Review Report on AB-FUBINACA by the WHO Expert Committee on Drug Dependence (ECDD) and were awarded a EUROTOX Travel Grant (2017). My team has also made substantial advances in evidencing the molecular mechanisms underlying the action of SCs on neurogenesis, a work that made the news (e.g. LUSA News Agency). These findings were groundbreaking as previously SC-related toxicity was mainly assessed at non-biologically relevant concentrations (above SC affinity to cannabinoid receptors). 2) Develop improved in vitro models to predict mood/cognitive adverse events (MCAEs) at early stages of pharmaceuticals R&D, having led the development of a unique workflow based on pharmacovigilance data mining and signaling pathway analyses that identified candidate mediators of MCAEs. As a result of my high-end scientific outputs, I ranked among the world's top 2% of most cited researchers for the past four consecutive years (2019-2022). My contributions have been INTERNATIONALLY RENOWNED by 1) integrating the Extended Expert list of the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA)'s Scientific Committee for NPS risk assessment, 2) supporting drug dependence liability evaluation for WHO's Expert Committee on Drug Dependence, 3) providing critical feedback on data for the Global Burden of Disease Studies, and 4) being Expert Reviewer in H2020/IMI- and other European agencies-funded Actions, Editorial Board Member in 5 international journals, and peer-reviewer for 34 journals. I have secured funds at national/European competitive Calls (Unit: 620k¿, Total: 5.3M¿) and integrated other funded grants' teams (total: 4M¿+). I integrate the Faculty of Pharmacy's teaching staff (adding to previous teaching experience) and have vast experience in mentoring Post-doc, PhD, MSc, and BSc students (including ERASMUS+), evidencing SCIENTIFIC LEADERSHIP.
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Identification

Personal identification

Full name
João Pedro Martins Soares de Castro e Silva

Author identifiers

Ciência ID
7310-EC2E-8DC1
ORCID iD
0000-0002-5656-0897
Google Scholar ID
HVZRnOwAAAAJ
Researcher Id
E-8444-2012

Email addresses

  • jp.silva@gmail.com (Professional)
  • jpmsilva@ff.up.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Substance Abuse
  • Medical and Health Sciences - Health Sciences - Substance Abuse
  • Medical and Health Sciences - Health Sciences - Substance Abuse
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Natural sciences - Biological Sciences - Molecular Biology
Education
Degree Classification
2011/05
Concluded
 Course on Laboratory Animal Science (FELASA B) (Pós-Graduação)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2005/01/01 - 2009/07/08
Concluded
 Ciências (Doutoramento)
Major in Especialidade: Biologia
Universidade do Minho, Portugal
"Novel Synthetic Compounds with Pharmacological Potential:protection Against Oxidative Stress" (THESIS/DISSERTATION)
 Approved with Distinction
2002/09/23 - 2004/12/20
Concluded
 Mestrado em Genética Molecular (Mestrado)
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
"Effect of new nitrogen compounds with pharmacological potential on oxidative stress protection" (THESIS/DISSERTATION)
 Very Good (highest classification possible)
1998/09 - 2002/09/01
Concluded
 Biologia Aplicada (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Development of growth, cell viability and lipid peroxidation evaluation tests in a fibroblast cell line exposed to nitrogen heterocycles with pharmacological potential" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2023/03/01 - Current Auxiliary Researcher (Research) REQUIMTE, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2016/05/01 - 2023/02/28 Contracted Researcher (Research) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2010/02/01 - 2016/04/30 Postdoc (Research) Universidade do Minho Centro de Engenharia Biológica, Portugal
2013/09/01 - 2014/08/31 Visiting Researcher (Research) University of California Riverside, United States
2013/02/01 - 2013/03/31 Visiting Researcher (Research) Universitair Medisch Centrum Groningen Thoraxcentrum, Netherlands
2009/02/01 - 2010/01/31 Contracted Researcher (Research) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
Projects

Grant

Designation Funders
2010/02 - 2016/04 Post-Doctoral Fellowship
SFRH/BPD/64958/2009
 Foundation for Science and Tecnology (FCT)
2005/01 - 2008/12 PhD Fellowship
SFRH/BD/17174/2004
 Foundation for Science and Tecnology (FCT)

Contract

Designation Funders
2023/03/01 - 2029/02/28 Unraveling the epigenetic impact of cannabinoids on neurodevelopment
2021.01789.CEECIND/CP1662/CT0014
10.54499/2021.01789.CEECIND/CP1662/CT0014
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/10/01 - 2023/12/31 METAMP-ADHD: Methylphenidate and amphetamine-induced synaptogenesis and neurite outgrowth in attention deficit hyperactivity disorder (ADHD)
EXPL/MED-FAR/0203/2021
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/03 - 2023/09/30 NeuroDeRisk: Neurotoxicity De-Risking in Preclinical Drug Discovery
821528
Principal investigator
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

European Union, Belgium
Innovative Medicines Initiative
Concluded
2018/07/01 - 2021/11/30 NeuroSCANN: Assessment of the modulatory effects of Synthetic CANNabinoids on NEUROnal development
PTDC/SAU-TOX/29584/2017
Principal investigator
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Unidade de Ciências Biomoleculares Aplicadas
UID/Multi/04378/2019
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/04 - 2019/03 DESignBIOtecHealth – New Technologies for Three Health Challenges of Modern Societies: Diabetes, Drug Abuse and Kidney Diseases
NORTE-01-0145-FEDER-000024
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 European Regional Development Fund
Ongoing
2016/03/01 - 2016/04/30 iBONE Therapies – Innovative therapies for bone regeneration
NORTE-01-0247-FEDER-003262
Post-doc Fellow
Universidade do Minho Centro de Engenharia Biológica, Portugal
 Agência Nacional de Inovação SA
Ongoing
2010/02/01 - 2016/04/30 Centre of Biological Engineering - University of Minho
UID/BIO/04469/2019
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2014 BCGrafts: Bacterial Cellulose-Made Prosthetic Vascular Grafts. Funded by: Portuguese Foundation for Science and Technology
PTDC/EBB-EBI/112170/2009
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2009/02 - 2010/01 Antioxidant activity of new di(hetero)arylamines; pharmacological potential against oxidative stress.
PTDC/QUI/68382/2006
Research Fellow
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Silva, João Pedro; Carvalho, Félix. Corresponding author: Silva, João Pedro. "Chapter 10.5-2: Nuevas sustâncias psicoativas en patologia dual". In Patología dual: Recomendaciones para la mejora de la calidad del proceso asistencial. Editorial Medica Panamericana (Madrid, Spain), 2023.
    Published
  2. Roque Bravo, Rita; Silva, João Pedro; Carmo, Helena; Carvalho, Félix; Dias da Silva, Diana. "Chapter 168-1: The Toll of Benzofurans in the Context of Drug Abuse.". In Handbook of Substance Misuse and Addictions., edited by Patel, VB; Preeedy, VR. Springer Nature, 2022.
    Accepted
  3. Silva, João Pedro; Carmo, Helena; Carvalho, Félix. Corresponding author: Silva, João Pedro. "Chapter 67-1: Synthetic Cannabinoids and Neurodevelopment". In Handbook of Substance Misuse and Addictions, edited by Patel, VB; Preedy, VR. Springer Nature, 2022.
    Accepted
  4. Malheiro, Rui; Gomes, TM; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. Corresponding author: Silva, João Pedro. "Cannabinoids and psychosis: current challenges of mechanistic toxicology". In TOXICOLOGICAL RISK ASSESSMENT AND MULTI- SYSTEM HEALTH IMPACTS FROM EXPOSURE, edited by Tsatsakis, A. Elsevier, 2021.
    Accepted
  5. Silva, João Pedro; Andrade, Fábia K.; Gama, Miguel. "Bacterial cellulose surface modification". In Bacterial Nano-cellulose: A Sophisticated Multifunctional material, edited by Klemm, D; Gatenholm, P; Gama, Miguel. CRC Press, Taylor & Francis Group (Florence, KY, USA), 2012.
    Published
  6. Coutinho, Olga P.; Machado, Vera; Pires, S; Silva, João Pedro. "Pharmacological potential of two new classes of synthetic compounds: protection or induction of cell damage and death". In A Toxicological/Pharmacological Approach to Chemico-Biological Interactions at a Membrane Level, edited by Jurado, A; Almeida, L; Pedroso de Lima, C. Transworld Research Network (Kerala, India), 2012.
    Published
Conference abstract
  1. Roque-Bravo, Rita; Carmo, Helena; Silva, João Pedro; Carvalho, Félix; Dias da Silva, Diana. "P21-11: Synthetic Cannabinoids and senescence markers in vitro: impact on cell proliferation, influence of cannabinoid receptors, and beta-galactosidase activity in SH-SY5Y cells". Paper presented in 57th Congress of the European Societies of Toxicology (EUROTOX), Ljubljana, 2023.
    Published
  2. Marques, S.I.; Stevanovic, V.; Arandelovic, J.; Savic, M.; Carmo, H.; Carvalho, F.; Sá, S.I.; Silva, João Pedro. Corresponding author: Silva, João Pedro. "Astrocyte response in rat brain is affected by pharmacologically-relevant doses of pharmaceuticals associated with neuropsychiatric/psychological adverse events". Paper presented in EUROTOX 2023, Ljubljana, 2023.
    Published • 10.1016/s0378-4274(23)00428-9
  3. Malheiro, R.F.; Carmo, H.; Carvalho, F.D.; Silva, João Pedro. Corresponding author: Silva, João Pedro. "P21-24: THJ-2201, a synthetic cannabinoid, modulates mitochondrial function and dynamics during the neurodifferentiation of NG108-15 cells at biologically relevant concentrations". Paper presented in EUROTOX 2023, Ljubljana, 2023.
    Published • 10.1016/s0378-4274(23)00831-7
  4. Silva, R.; Barbosa, D.J.; Carmo, H.; Carvalho, F.; da Silva, D. Dias; Silva, João Pedro. Corresponding author: Silva, João Pedro. "P21-18: The impact of ADB-FUBINACA on the differentiation, maturation and astrocyte activation in in vitro primary hippocampal cultures". Paper presented in EUROTOX 2023, Ljubljana, 2023.
    Published • 10.1016/s0378-4274(23)00825-1
  5. Pereira-Teixeira, C.; Almeida, M.; Carmo, H.; Carvalho, F.; Silva, João Pedro. Corresponding author: Silva, João Pedro. "P21-12: The Synthetic Sannabinoid ADB-FUBINACA decreases global DNA methylation during the neuronal differentiation of NG108-15 cells by increasing TET activity". Paper presented in EUROTOX 2023, Ljubljana, 2023.
    Published • 10.1016/s0378-4274(23)00819-6
  6. da Silva, Diana Dias; Roque-Bravo, R.; Silva, João Pedro; Carmo, Helena; Carvalho, Félix. "The synthetic cannabinoids ADB-FUBINACA and AMB-FUBINACA accelerate SH-SY5Y proliferation via stimulation of CB1 and CB2 cannabinoid receptors". Paper presented in II TOXRUN International Congress, Porto, 2023.
    Published
  7. Marques, Sandra; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Pharmaceuticals associated with mood and cognitive adverse events promote epigenetic changes in human-induced pluripotent stem cell–derived glutamatergic neurons at clinically relevant concentrations". Paper presented in SOT 2023, 2023.
  8. R. Roque Bravo; D.J. Barbosa; H. Carmo; Silva, João Pedro; F. Carvalho; D. Dias da Silva. "SOC-IV-06 The influence of selected synthetic cannabinoids on in vitro proliferation and viability of neuronal cell models". 2022.
    10.1016/j.toxlet.2022.07.163
  9. R. Silva; D.J. Barbosa; H. Carmo; F. Carvalho; D. Dias da Silva; Silva, João Pedro. "P16-12 The synthetic cannabinoid THJ-2201 increases the differentiation of primary hippocampal neurons and early astrocyte activation but decreases neuronal maturation". 2022.
    10.1016/j.toxlet.2022.07.602
  10. R.F. Malheiro; H. Carmo; F. Carvalho; Silva, João Pedro. "P16-10 The synthetic cannabinoid ADB-FUBINACA modulates mitochondrial activity and dynamics during neurodifferentiation of NG108-15 cells". 2022.
    10.1016/j.toxlet.2022.07.600
  11. Silva, João Pedro. "IND02-03 Improving the preclinical prediction of psychological/psychiatric adverse effects". 2022.
    10.1016/j.toxlet.2022.07.237
  12. Teixeira, Catarina; Garcia, MR; Roque-Bravo, Rita; Carmo, Helena; Carvalho, Félix; Silva, João Pedro; da Silva, Diana Dias. "Synthetic cannabinoids affect the expression of autophagic mediators ATG5, BECLIN-1, RAB7A and LC3 in brain-derived NG108-15 cells". Paper presented in I International Congress of TOXRUN – Toxicology Research Unit of IUCS” and “V International Congress of the Portuguese Association of Forensic Sciences, 2022.
    Published
  13. Roque-Bravo, Rita; Barbosa, DJ; Carmo, Helena; Silva, João Pedro; Carvalho, Félix; da Silva, Diana Dias. "Synthetic cannabinoids AMB-FUBINACA, ADB-FUBINACA, AB-CHMINACA and THJ-2201 impact on in vitro viability and proliferation of primary rat hippocampal neurons and SH-SY5Y cells". Paper presented in I International Congress of TOXRUN – Toxicology Research Unit of IUCS” and “V International Congress of the Portuguese Association of Forensic Sciences, 2022.
  14. Maria Rita Garcia; Rita Roque Bravo; Helena Carmo; Félix Carvalho; Silva, João Pedro; Diana Dias da Silva. "Mitochondrial effects and Caspase-3 activation induced by synthetic cannabinoids in NG108-15 cells". Paper presented in I International Congress of TOXRUN – Toxicology Research Unit of IUCS” and “V International Congress of the Portuguese Association of Forensic Sciences, 2022.
    10.51126/revsalus.v4isup.264
  15. Lobato-Freitas, Carolina; Carmo, Helena; Carvalho, Félix; Silva, João Pedro; da Silva, Diana Dias. "AMB-FUBINACA, AB-CHMINACA and HU-308’s effects on in vitro differentiation and proliferation of NG108-15 cells". Paper presented in I International Congress of TOXRUN – Toxicology Research Unit of IUCS” and “V International Congress of the Portuguese Association of Forensic Sciences, 2022.
  16. Henriques, Rita; Bravo, Rita R.; Carmo, Helena; Silva, João Pedro; Carvalho, Félix. "In vitro evaluation of telomere length in SH-SY5Y neuroblastoma cells exposed to heroin and tramadol". Paper presented in Young Researchers Meating IJUP, Porto, 2022.
    Published
  17. Marques, Sandra; Silva, João Pedro; Carmo, Helena; Carvalho, Félix. "Varenicline increases histone H3 acetylation, while affecting global DNA methylation on differentiated SH-SY5Y neuroblastoma cells. Published in Toxicology Letters (SENIOR AUTHOR)". Paper presented in EUROTOX2021, 2021.
    Published
  18. Malheiro, Rui; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "In vitro evaluation of the effects of the synthetic cannabinoids ADB-FUBINACA and AMB-FUBINACA on mitochondrial function during neurodifferentiation. Published in Toxicology Letters (SENIOR AUTHOR)". Paper presented in EUROTOX2021, 2021.
    Published
  19. Faria, AC; Carmo, Helena; Teixeira, Catarina; Rouxinol, D; Silva, João Pedro; Carvalho, Félix; Bastos, ML; Dias da Silva, Diana. "Administration of 3,4-dimethylmethcathinone (3,4-DMMC) and methylone increases the release of antidiuretic hormone in female Wistar rats. Published in Toxicology Letters". Paper presented in EUROTOX2019 – 55th Congress of the European Societies of Toxicology, Helsinki, 2019.
    Accepted
  20. Teixeira, C; Carmo, Helena; Rouxinol, D; Faria, AC; Silva, João Pedro; Carvalho, Félix; Bastos, ML; Dias da Silva, Diana. "Administration of 3,4-dimethylmethcathinone (3,4-DMMC) and methylone to Wistar rats disturbs the energetic and antioxidant homeostasis in liver, brain, kidney and heart. Published in Toxicology Letters". Paper presented in EUROTOX2019 – 55th Congress of the European Societies of Toxicology, Helsinki, 2019.
  21. Rouxinol, D; Dias da Silva, Diana; Teixeira, C; Faria, AC; Silva, João Pedro; Carvalho, Félix; Bastos, ML; Carmo, Helena. "Biodistribution of the new psychoactive stimulant 3,4-dimethylmethcathinone (3,4-DMMC) in Wistar rats assessed by gas chromatography-mass spectrometry (GC-MS). Published in Toxicology Letters". Paper presented in Eurotox2019, Helsinki, 2019.
  22. Roque Bravo, Rita; Carmo, Helena; Silva, João Pedro; Carvalho, Félix; Bastos, ML; Dias da Silva, Diana. "Metabolism plays an important role in the in vitro hepatotoxicity of butylone, buphedrone, and 3,4-dimethylmetcathinone (3,4-DMMC). Published in Toxicology Letters". Paper presented in EUROTOX2019, Helsinki, 2019.
    Accepted
  23. Alexandre, JA; Malheiro, RM; Dias da Silva, Diana; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. Corresponding author: Silva, João Pedro. "Synthetic cannabinoids 5F-PB22 and THJ-2201 promote in vitro CB1 receptor-dependent neuronal differentiation at in vivo-relevant concentrations. Published in Toxicology Letters". Paper presented in EUROTOX2019, Helsinki, 2019.
    Accepted
  24. Parra, J; Araújo, ARTS; Carvalho, Félix; Carmo, H; Silva, João Pedro. "Neurotoxicity assessment of four synthetic cathinones in neuroblastoma cells at in vivo relevant concentrations. Published in Toxicology Letters (SENIOR AUTHOR)". Paper presented in EUROTOX 2018, 2018.
    10.1016/j.toxlet.2018.06.859 P
  25. Parra, J; Araújo, ARTS; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Neurotoxicity assessment of four synthetic cathinones in neuroblastoma cells at in vivo relevant concentrations. Published in Toxicology Letters (SENIOR AUTHOR)". Paper presented in EUROTOX 2018, 2018.
  26. Silva, João Pedro; Carmo, Helena; Carvalho, Félix. "In vitro nephrotoxicity of synthetic cannabinoids. Published in Toxicology Letters". Paper presented in EUROTOX 2017, 2017.
  27. Silva, João Pedro; Dhall, Sandeep; Alamat, R; Martins-Green, Manuela. "Toxins in third hand cigarette smoke alter the redox balance in the wound tissue resulting in impaired healing. Published in Wound Repair and Regeneration". Paper presented in Meeting of the Wound Healing Society, 2015.
  28. Silva, João Pedro; Dhall, Sandeep; Chan, Alex; Gama, F. Miguel; Martins-Green, Manuela. "Improved burn wound healing by an antimicrobial peptide released from conjugates with dextrin embedded in a carbopol hydrogel. Published in Wound Repair and Regeneration". Paper presented in Meeting of the Wound Healing Society, 2015.
  29. Antunes, I. F.; Gonçalves, Catarina; Silva, João Pedro; Ferreira, Miguel Filipe; Martins, José Alberto; Geraldes, C. F. G. C.; Lalatonne, Yoann; et al. "In vivo dextrin nanomagnetogel performance as dual imaging bioprobe. Published in European Journal of Nuclear Medicine and Molecular Imaging". Paper presented in European Journal of Nuclear Medicine and Molecular Imaging, 2014.
  30. Silva, João Pedro; Dhall, Sandeep; Martins-Green, Manuela; Lyubovitsky, J.. "Improved healing of burns with alginate sponge dressings containing insulin encapsulated in PLGA microparticles. Published in Wound Repair and Regeneration". Paper presented in Wound Healing Society, 2014.
  31. Silva, João Pedro; Ramos, Reinaldo; Rodrigues, Ana Cristina; Costa, Raquel; Guardao, Luisa; Soares, Raquel; Vilanova, Manuel; Domingues, Lucilia; Gama, F. Miguel. "Bioactivity of the recombinant human antimicrobial peptide LL37: a key role in wound healing through vascularization. Published in Journal of Tissue Engineering and Regenerative Medicine". Paper presented in TERMIS-EU Annual Meeting, 2012.
  32. Leitão, Alexandre F.; Gupta, S.; Silva, João Pedro; Reviakine, I.; Gama, F. Miguel. "Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite, Published in Journal of Tissue Engineering and Regenerative Medicine". Paper presented in TERMIS-EU Annual Meeting, 2012.
  33. Andrade, Fábia K.; Silva, João Pedro; Carvalho, Manuela; Castanheiro, EMS; Soares, Raquel; Gama, Francisco Miguel. "Hemocompatibility study of bacterial cellulose. Published in Histology and histopathology: Cellular and Molecular Biology". Paper presented in TERMIS-EU Annual Meeting, 2011.
  34. Silva, João Pedro; Gomes, Andreia C.; Coutinho, Olga P.. "Polyphenolic compounds protect and repair oxidative DNA damage in a neuronal cell model. Published in Free Radical Research". Paper presented in Society for Free Radical Research Europe International Meeting, 2008.
  35. Silva, João Pedro; Areias, Filipe; Coutinho, Olga P.. "Protective role of new nitrogen compounds on ROS/RNS-mediated damage to PC12 cells. Published in Cell Stress Chaperones online". Paper presented in World Conference of Stress, 2007.
  36. Pinto-Basto, Diana; Silva, João Pedro; Queiroz, Maria-Joao R. P.; Moreno, Antonio J.; Coutinho, Olga P.. "Effects of two new di(hetero)arylamines on prevention of oxidative stress induced in two different biological models. Published in Free Radical Research". Paper presented in Society for Free Radical Research Europe International Meeting, 2007.
  37. Pinto-Basto, Diana; Castro, MF; Silva, João Pedro; Coutinho, Olga P.. "Quercetin enhances UVA-induced DNA damage in a rat fibroblast cell line. Published in Free Radical Research". Paper presented in Society for Free Radical Research Europe International Meeting, 2007.
    Published
Conference paper
  1. Silva, João Pedro; Silva-Carvalho, Ricardo; Gonçalves, Carine; Costa, César; Sousa, Jeremy; Silva-Gomes, Rita; Castro, Gil; et al. "Targeting TB treatment: Antimicrobial Peptide delivery using Hyaluronic Acid nanogels". Paper presented in Respiratory Drug Delivery Asia, Goa, 2016.
    Published
  2. Pinto-Basto, Diana; Silva, João Pedro; Queiroz, Maria-Joao R. P.; Moreno, Antonio J.; Coutinho, Olga P.. "Effects of two new di(hetero)arylamines on prevention of oxidative stress induced in two different biological models". Paper presented in EUROPEAN MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL, 2007.
    Published
Conference poster
  1. Galipeau, Chloé; Miguel Farinha-Ferreira; Marques, Sandra; Silva, João Pedro; Mariani, JC; Diebolt, S; Barthe, L; et al. "The role of 5-HT2AR activation in the long-lasting effects of psilocybin". Paper presented in European Molecular Biology Organization (EMBO) Young Scientist Forum, 2023.
  2. Roque Bravo, Rita; Carmo, Helena; Silva, João Pedro; Carvalho, Félix; Dias da Silva, Diana. "Synthetic Cannabinoids and senescence markersi n vitro: impact on cell proliferation, influence of cannabinoid receptors, and beta-galactosidase activity in SH-SY5Y cells". Paper presented in 57th Congress of the European Societies of Toxicology (EUROTOX), 2023.
  3. Malheiro, RF; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. Corresponding author: Silva, João Pedro. "THJ-2201, a synthetic cannabinoid, modulates mitochondrial function and dynamics during the neurodifferentiation of NG108-15 cells at biologically relevant concentrations". Paper presented in EUROTOX 2023, 2023.
  4. Silva, Rafaela; Barbosa, Daniel José; Carmo, Helena; Carvalho, Félix; da Silva, D. Dias; Silva, João Pedro. Corresponding author: Silva, João Pedro. "The impact of ADB-FUBINACA on the differentiation, maturation and astrocyte activation in in vitro primary hippocampal cultures.". Paper presented in EUROTOX 2023, 2023.
  5. Pereira-Teixeira, C.; Almeida, Mariana; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. Corresponding author: Silva, João Pedro. "The synthetic cannabinoid ADB-FUBINACA decreases global DNA methylation during the neuronal differentiation of NG108-15 cells by increasing TET activity". Paper presented in EUROTOX 2023, 2023.
  6. Almeida, Ana Sofia; Silva, Bárbara; Silva, João Pedro; Remião, Fernando; Fernandes, Carla. "Evaluation of stereochemical stability and enantioselectivity of MDPV enantiomers on SH-SY5Y human neuronal cells". Paper presented in IJUP 2023, 2023.
  7. Dias-da-Silva, Diana; Roque Bravo, Rita; Silva, João Pedro; Carmo, Helena; Carvalho, Félix. Corresponding author: Dias-da-Silva, Diana. "The synthetic cannabinoids ADB-FUBINACA and AMB-FUBINACA accelerate SH-SY5Y proliferation via stimulation of CB1 and CB2 cannabinoid receptors". Paper presented in II TOXRUN International Congress, 2023.
  8. Sandra Marques; Catarina Pereira-Teixeira ; Helena Carmo; Carvalho, Félix; João Pedro Silva; Marques, Sandra; Carmo, Helena; Silva, João Pedro. "Pharmaceuticals associated with mood and cognitive adverse events promote epigenetic changes in human-induced pluripotent stem cells-derived glutamatergic neurons at clinically-relevant concentrations". Paper presented in Society of Toxicology - 62nd Annual Meeting & TOXEXPO, 2023.
  9. Araújo, Ana Margarida; Marques, Sandra; Pinho, Paula Guedes; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Application of a GC-MS metabolomics approach to reveal how sub-toxic concentrations of ciprofloxacin affect the brain". Paper presented in 12th National Meeting on Chromatography, 2022.
  10. Lobato-Freitas, Carolina; Carmo, Helena; Carvalho, Félix; Silva, João Pedro; da Silva, Diana Dias. "The effects of Synthetic Cannabinoids ADB-FUBINACA, AMB-FUBINACA, AB-CHMINACA and HU-308 on Differentiation and Proliferation of Brain NG108-15 Cells". Paper presented in Lisbon Addictions 2022, 2022.
  11. da Silva, Diana Dias; Teixeira, Catarina; Garcia, Maria Rita; Roque-Bravo, Rita; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Crosstalk Between Autophagic Intermediaries in In Vitro Neurotoxicity Induced by Synthetic Cannabinoids". Paper presented in Lisbon Addictions 2022, 2022.
  12. Gomes, Telma M; Malheiro, Rui; Almeida, Mariana; Carmo, Helena; Silva, João Pedro; Carvalho, Félix. "The synthetic cannabinoid ADB-FUBINACA modulates epigenetic mechanisms during in vitro neuronal differentiation at biologically relevant concentrations". Paper presented in Lisbon Addictions 2022, 2022.
  13. Marques, Sandra; Carmo, Helena; Carvalho, Félix; Sá, Susana I; Sá SI; Silva, João Pedro. "An improved IHC image post-processing method for the semi-automatic quantification of astrocyte number and activation". Paper presented in 8th International Electronic Conference on Medicinal Chemistry, 2022.
  14. R. Silva; D.J. Barbosa; H. Carmo; F. Carvalho; D. Dias da Silva; Silva, João Pedro. "P16-12 The synthetic cannabinoid THJ-2201 increases the differentiation of primary hippocampal neurons and early astrocyte activation but decreases neuronal maturation". 2022.
    10.1016/j.toxlet.2022.07.602
  15. R.F. Malheiro; H. Carmo; F. Carvalho; Silva, João Pedro. "P16-10 The synthetic cannabinoid ADB-FUBINACA modulates mitochondrial activity and dynamics during neurodifferentiation of NG108-15 cells". Paper presented in XVIth International Congress of Toxicology, 2022.
    10.1016/j.toxlet.2022.07.600
  16. Teixeira, Catarina; Garcia, Maria Rita; Roque-Bravo, Rita; Carmo, Helena; Carvalho, Félix; Silva, João Pedro; da Silva, Diana Dias. "Autophagic proteins ATG5, Beclin-1, Rab7A and LC3 are altered by Synthetic Cannabinoids in NG108-15 brain-derived cells". Paper presented in 15th IJUP (Meeting of University of Porto’s Young Researchers), 2022.
  17. Lobato-Freitas, Carolina; Carmo, Helena; Carvalho, Félix; Silva, João Pedro; da Silva, Diana Dias. "Synthetic Cannabinoids in Differentiation and Proliferation of NG108-15 Cells in vitro". Paper presented in 15th IJUP (Meeting of University of Porto’s Young Researchers), 2022.
  18. Catarina Pereira Teixeira; Maria Rita Garcia; Rita Roque Bravo; Helena Carmo; Félix Carvalho; Silva, João Pedro; Diana Dias da Silva. "Synthetic cannabinoids affect the expression of autophagic mediators ATG5, BECLIN-1, RAB7A and LC3 in brain-derived NG108-15 cells". Paper presented in I International Congress of TOXRUN – Toxicology Research Unit of IUCS” and “V International Congress of the Portuguese Association of Forensic Sciences, 2022.
    10.51126/revsalus.v4isup.371
  19. Rita Roque Bravo; Daniel Barbosa; Helena Carmo; Silva, João Pedro; Félix Carvalho; Diana Dias da Silva. "Synthetic cannabinoids AMB-FUBINACA, ADB-FUBINACA, AB-CHMINACA and THJ-2201 impact on in vitro viability and proliferation of primary rat hippocampal neurons and SH-SY5Y cells". Paper presented in I International Congress of TOXRUN – Toxicology Research Unit of IUCS” and “V International Congress of the Portuguese Association of Forensic Sciences, 2022.
    10.51126/revsalus.v4isup.426
  20. Lobato-Freitas, Carolina; Carmo, Helena; Carvalho, Félix; Silva, João Pedro; da Silva, Diana Dias. "AMB-FUBINACA, AB-CHMINACA and HU-308’s effects on in vitro differentiation and proliferation of NG108-15 cells". Paper presented in I International Congress of TOXRUN – Toxicology Research Unit of IUCS” and “V International Congress of the Portuguese Association of Forensic Sciences, 2022.
  21. Araújo, Ana Margarida; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Can fluoroquinolones affect the brain? - A GC-MS metabolomics approach reveals early neurotoxicity events triggered by ciprofloxacin". Paper presented in 61st Society of Toxicology (SOT) Annual Meeting, 2022.
  22. Malheiro, Rui; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "In vitro evaluation of the effects of the synthetic cannabinoids ADB-FUBINACA and AMB-FUBINACA on mitochondrial function during neurodifferentiation. (SENIOR AUTHOR)". Paper presented in EUROTOX2021 - 56th Virtual Congress of the European Societies of Toxicology, 2021.
  23. Marques, Sandra; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Varenicline increases histone H3 acetylation, while affecting global DNA methylation on differentiated SH-SY5Y neuroblastoma cells. (SENIOR AUTHOR)". Paper presented in EUROTOX2021 – 56th Virtual Congress of the European Societies of Toxicology, 2021.
  24. Malheiro, Rui; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "The synthetic cannabinoids ADB-FUBINACA and THJ-2201 affect mitochondrial function during neuronal differentiation of NG108-15 cells at human-relevant concentrations. (SENIOR AUTHOR)". Paper presented in Jornadas Ibéricas de Toxicologia (virtual meeting), 2021.
  25. Malheiro, Rui; Gomes, TM; Galani, M; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "ADB-FUBINACA, a synthetic cannabinoid, enhances in vitro neuronal differentiation at biologically relevant concentrations. (SENIOR AUTHOR)". Paper presented in 2021 Society of Toxicology Virtual Annual Meeting, 2021.
  26. Dias da Silva, Diana; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Pharmacokinetics and pharmacodynamics of the synthetic cannabinoid UR-144 and its halogenated analogue 5F-UR-144 (XLR-11). (SENIOR AUTHOR)". Paper presented in Lisbon Addictions 2019, 2019.
  27. Roque Bravo, Rita; Almeida, TD; Valente, MJ; Ferreira, B; Rebelo, R; Silva, João Pedro; Carvalho, Félix; et al. "The in vitro hepatotoxicity of the new recreational drug 3-methylmethcathinone (3-MMC) involves autophagy and apoptosis.". Paper presented in Lisbon Addictions 2019, 2019.
  28. Roque Bravo, Rita; Carmo, Helena; Silva, João Pedro; Carvalho, Félix; Bastos, ML; Dias da Silva, Diaa. "Insights into benzo fury toxicity: 5-(2-aminopropyl)benzofuran and 6-(2-aminopropyl)benzofuran disrupt oxidative, energetic and mitochondrial homeostasis of hepatocytes in vitro.". Paper presented in Lisbon Addictions 2019, 2019.
  29. Faria, AC; Carmo, Helena; Silva, João Pedro; Carvalho, Félix; Bastos, ML; Dias da Silva, Diana. "Hyponatraemia induced by synthetic phenethylamines.". Paper presented in Lisbon Addictions 2019, 2019.
  30. Rouxinol, D; Dias da Silva, Diana; Silva, João Pedro; Carvalho, Félix; Bastos, ML; Carmo, Helena. "The newly emerged designer psychostimulant 3,4-dimethylmethcathinone (3,4-DMMC)". Paper presented in Lisbon Addictions 2019, 2019.
  31. Faria, AC; Carmo, Helena; Teixeira, C; Rouxinol, D; Silva, João Pedro; Carvalho, Félix; Bastos, ML; Dias da Silva, Diana. "Administration of 3,4-dimethylmethcathinone (3,4-DMMC) and methylone increases the release of antidiuretic hormone in female Wistar rats". Paper presented in EUROTOX2019, 2019.
  32. Teixeira, C; Carmo, Helena; Rouxinol, D; Faria, AC; Silva, João Pedro; Carvalho, Félix; Bastos, ML; Dias da Silva, Diana. "Administration of 3,4-dimethylmethcathinone (3,4-DMMC) and methylone to Wistar rats disturbs the energetic and antioxidant homeostasis in liver, brain, kidney and heart.". Paper presented in EUROTOX2019, 2019.
  33. Rouxinol, D; Dias da Silva, Diana; Teixeira, C; Faria, AC; Silva, João Pedro; Carvalho, Félix; Bastos, ML; Carmo, Helena. "Biodistribution of the new psychoactive stimulant 3,4-dimethylmethcathinone (3,4-DMMC) in Wistar rats assessed by gas chromatography-mass spectrometry (GC-MS)". Paper presented in EUROTOX2019, 2019.
  34. Alexandre, JA; Malheiro, RM; Dias da Silva, Diana; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Synthetic cannabinoids 5F-PB22 and THJ-2201 promote in vitro CB1 receptor-dependent neuronal differentiation at in vivo-relevant concentrations. (SENIOR AUTHOR)". Paper presented in EUROTOX2019, 2019.
  35. Parra, J; Araújo, ARTS; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Neurotoxicity assessment of four synthetic cathinones in neuroblastoma cells at in vivo relevant concentrations. (SENIOR AUTHOR)". Paper presented in EUROTOX2018 – 54th Congress of the European Societies of Toxicology, 2018.
  36. Alexandre, JA; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Synthetic cannabinoids enhance neuronal differentiation in neuroblastoma cells at in vivo relevant concentrations. (SENIOR AUTHOR)". Paper presented in EUROTOX2018 – 54th Congress of the European Societies of Toxicology, 2018.
  37. Eira, SG; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Role of cannabinoids in neuronal development. (SENIOR AUTHOR)". Paper presented in Jornadas Científicas do Instituto Universitário de Ciências da Saúde (CESPU), 2018.
  38. Silva-Carvalho, Ricardo; Cristelo, Cecília; Silva, João Pedro; Coutinho, Olga P.; Castro, António G.; Pedrosa, Jorge; Appelberg, Rui; Gama, F. Miguel. "Delivery of nanogel formulations with antimicrobial peptides for the treatment of mycobacteriosis.". Paper presented in CEB Annual Meeting 2017, 2017.
  39. Rodrigues, Ana Cristina; Cardoso, B; Machado, A; Queirós, E; Lima, SC; Reis, S; Silva, João Pedro; Gama, F. Miguel. "Development of bacterial cellulose wound dressings with controlled delivery of vitamin D3.". Paper presented in CEB Annual Meeting 2017, 2017.
  40. Silva, João Pedro; Silva-Carvalho, Ricardo; Cristelo, Cecília; Gonçalves, Carine; Sousa, Jeremy; Silva-Gomes, Rita; Castro, António G.; et al. "Delivery of nanogel formulations with antimicrobial peptides for the treatment of mycobacteriosis.". Paper presented in GluPor - 12th Meeting of the Carbohydrates Group, 2017.
  41. Silva, João Pedro; Carmo, Helena; Carvalho, Félix. "In vitro nephrotoxicity of synthetic cannabinoids.". Paper presented in EUROTOX2017 – 53rd Congress of the European Societies of Toxicology, 2017.
  42. Silva, João Pedro; Carmo, Helena; Carvalho, Félix. "In vitro nephrotoxicity of synthetic cannabinoids.". Paper presented in Lisbon Addictions 2017, 2017.
  43. Silva, João Pedro; Dhall, Sandeep; Chan, Alex; Gama, F. Miguel; Martins-Green, Manuela. "Improved burn wound healing by an antimicrobial peptide released from conjugates with dextrin embedded in a carbopol hydrogel.". Paper presented in 25th Annual Meeting of the Wound Healing Society SAWC-Spring/WHS Joint Meeting, 2015.
  44. Gama, F. Miguel; Silva, João Pedro; Castro, António G.; Pedrosa, Jorge; Appelberg, Rui. "Antimicrobial peptide delivery for mycobacteriosis therapy.". Paper presented in Gordon Research Conference: Antimicrobial Peptides, 2015.
  45. Silva, João Pedro; Dhall, Sandeep; Garcia, Monika; Gama, F. Miguel; Martins-Green, Manuela. ". Improved burn wound healing by an antimicrobial peptide released from dextrin conjugates embedded in a carbopol hydrogel.". Paper presented in Gordon Research Conference: Antimicrobial Peptides, 2015.
  46. Silva, João Pedro; Dhall, Sandeep; Martins-Green, Manuela; Lyubovitsky, J.. "Assessment of burn wound tissue in situ by multiphoton microscopy employing fluorescence and second harmonic generation contrasts in live animals.". Paper presented in 24th Annual Meeting of the Wound Healing Society SAWC-Spring/WHS Joint Meeting, 2014.
  47. Antunes, Inês; Gonçalves, Catarina; Silva, João Pedro; Ferreira, Miguel Filipe; Martins, José Alberto; Geraldes, Carlos F. G. C.; Lalatonne, Yoann; et al. "n vivo dextrin nanomagnetogel performance as dual imaging bioprobe.". Paper presented in Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), 2014.
  48. Leitão, Alexandre F.; Gupta, S.; Silva, João Pedro; Reviakine, I.; Gama, F. Miguel. "Biocellulose grafts: The future in artificial vascular grafts? Preliminary results". Paper presented in First International Symposium on Vascular Tissue Engineering, 2013.
  49. Gonçalves, Sara; Silva, João Pedro; Dourado, Fernando; Rodrigues, Lígia R.. "Bacterial cellulose as a feasible cell carrier for retinal pigment epithelium cell transplantation". Paper presented in FEBS Workshop: Biological Surfaces and Interfaces, 2013.
  50. Araujo, J.; Padrão, Jorge; Silva, João Pedro; Dourado, Fernando; Correia, D. M.; Botelho, G.; Gomez Ribelles, J. L.; Lanceros-Mendez, Senentxu; Sencadas, Vitor. "Processing and characterization of a-elastin.". Paper presented in 25th European Conference on Biomaterials, 2013.
  51. Silva, João Pedro; Ramos, Reinaldo; Rodrigues, AC; Costa, R; Guardao, Luisa; Soares, Raquel; Vilanova, Manuel; Domingues, Lucilia; Gama, F. Miguel. "Bioactivity of the recombinant human antimicrobial peptide LL37: a key role in wound healing through vascularization". Paper presented in 3rd TERMIS World Congress, 2012.
  52. Leitão, Alexandre F.; Gupta, S.; Silva, João Pedro; Reviakine, I.; Gama, F. Miguel. "Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite". Paper presented in 3rd TERMIS World Congress, 2012.
  53. Silva, João Pedro; Machado, Vera; Calhelha, Ricardo; Queiroz, Maria-Joao R. P.; Coutinho, Olga P.. "Novel di(hetero)diarylamines on the prevention of oxidative damage induced to H9c2 myoblasts". Paper presented in III Spanish and Portuguese Congress on Free Radicals - International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species, 2010.
  54. Machado, Vera; Calhelha, Ricardo; Queiroz, Maria-Joao R. P.; Silva, João Pedro; Coutinho, Olga P.. "Synthetic di(hetero)arylamines in the prevention of cell damage and death". Paper presented in XVII National Congress of Biochemistry, 2010.
  55. Silva, João Pedro; Gomes, Andreia C.; Coutinho, Olga P.. "Polyphenolic compounds protect and repair oxidative DNA damage in a neuronal cell model". Paper presented in SFRR Europe Meeting, 2008.
  56. Silva, João Pedro; Sardao, Vilma A.; Proença, Fernanda; Coutinho, Olga P.; Oliveira, Paulo J.. "Nitrogen compounds as protectors of oxidative damage induced in H9c2 myoblasts". Paper presented in 16th Euroconference on Apoptosis and 5th Swiss Apoptosis Meeting, 2008.
  57. Silva, João Pedro; Areias, Filipe M.; Coutinho, Olga P.. "Protective role of new nitrogen compounds on ROS/RNS-mediated damage to PC12 cells". Paper presented in World Conference of Stress, 2007.
  58. Pinto-Basto, Diana; Silva, João Pedro; Queiroz, Maria-Joao R. P.; Moreno, Antonio J.; Coutinho, Olga P.. "Effects of two new di(hetero)arylamines on prevention of oxidative stress induced in two different biological models". Paper presented in SFRR Europe Meeting, 2007.
  59. Castro, MF; Pinto-Basto, Diana; Silva, João Pedro; Coutinho, Olga P.. "Quercetin enhances UVA-induced DNA damage in a rat fibroblast cell line". Paper presented in SFRR Europe Meeting, 2007.
  60. Silva, João Pedro; Areias, Filipe M.; Coutinho, Olga P.. "Oxidative stress protection by newly synthesized nitrogen compounds". Paper presented in International Free Radical Summer School: Biomarkers of Oxidative Stress and Responses, 2006.
  61. Silva, João Pedro; Areias, Filipe M.; Coutinho, Olga P.. "Antioxidant properties of new heterocycle nitrogen compounds". Paper presented in XV National Congress of Biochemistry, 2006.
  62. Pinto-Basto, Diana; Silva, João Pedro; Queiroz, Maria-Joao R. P.; Moreno, Antonio J.; Coutinho, Olga P.. "Evaluation of the antioxidant activity of synthetic diarylamines in the benzo[B]thiophene series". Paper presented in XV National Congress of Biochemistry, 2006.
  63. Silva, F; Silva, B; Silva, João Pedro; Coutinho, Olga P.; Dias, A. "Antioxidant and neuroprotective properties of Scutellaria lateriflora". Paper presented in 53rd Annual Meeting of the Society of Medicinal Plant Research (GA), 2005.
  64. Oliveira, P; Silva, João Pedro; Coutinho, Olga P.; Dias, AC. "Anti-UV properties of lipidic extracts of three selected marine microalgae". Paper presented in 53rd Annual Meeting of the Society of Medicinal Plant Research (GA), 2005.
  65. Silva, João Pedro; Areias, Filipe M.; Coutinho, Olga P.. "Reactive oxygen species scavenging properties of newly synthesized nitrogen compounds". Paper presented in Joint Meeting of the Oxygen Club of California / University of Turin on Oxidants and Antioxidants in Biology, 2005.
  66. Areias, Filipe M.; Bettencourt, Ana P.; Coutinho, Olga P.; Fernandes, Francisco; Proença, Fernanda; Silva, João Pedro. "Antioxidant activity of phenol incorporated in nitrogen-containing compounds". Paper presented in 1st International Congress on Antioxidant Methods, 2004.
  67. Silva, João Pedro; Areias, Filipe M.; Coutinho, Olga P.. "Oxidative stress protection by nitrogen compounds with pharmacological potential". Paper presented in XIV National Congress of Biochemistry, 2004.
  68. Silva, João Pedro; Santos, ML; Areias, Filipe M.; Coutinho, Olga P.. "Protective effects of newly synthesised nitrogen compounds on oxidative stress induced in a rat fibroblast cell line". Paper presented in 1st Luso-Spanish Congress on Free Radicals & 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine, 2003.
  69. Santos, ML; Silva, João Pedro; Areias, Filipe M.; Coutinho, Olga P.. "Protective effects of newly synthesized nitrogen compounds on oxidative stress induced in a rat fibroblast cell line". Paper presented in XIII National Congress of Biochemistry, 2002.
Journal article
  1. Bhattacharjee, Natalia V; Silva, João Pedro; Vollset, SE; et al.. "Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021". The Lancet 403 10440 (2024): 2057-2099. http://dx.doi.org/10.1016/s0140-6736(24)00550-6.
    10.1016/s0140-6736(24)00550-6
  2. Vollset, Stein Emil; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021". The Lancet 403 10440 (2024): 2204-2256. http://dx.doi.org/10.1016/s0140-6736(24)00685-8.
    10.1016/s0140-6736(24)00685-8
  3. Steinmetz, Jaimie D; Silva, João Pedro; Dua, T; et al.. "Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021". The Lancet Neurology 23 4 (2024): 344-381. http://dx.doi.org/10.1016/s1474-4422(24)00038-3.
    10.1016/s1474-4422(24)00038-3
  4. Naghavi, Mohsen; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021". The Lancet (2024): http://dx.doi.org/10.1016/s0140-6736(24)00367-2.
    10.1016/s0140-6736(24)00367-2
  5. Ferrari, Alize J; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021". The Lancet (2024): http://dx.doi.org/10.1016/s0140-6736(24)00757-8.
    Accepted • 10.1016/s0140-6736(24)00757-8
  6. Schumacher, Austin E; Silva, João Pedro; Murray, CJL; et al.. "Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021". The Lancet (2024): http://dx.doi.org/10.1016/s0140-6736(24)00476-8.
    10.1016/s0140-6736(24)00476-8
  7. Ledesma, Jorge R; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Global, regional, and national age-specific progress towards the 2020 milestones of the WHO End TB Strategy: a systematic analysis for the Global Burden of Disease Study 2021". The Lancet Infectious Diseases (2024): http://dx.doi.org/10.1016/s1473-3099(24)00007-0.
    10.1016/s1473-3099(24)00007-0
  8. Araújo, Ana Margarida; Marques, Sandra; Guedes de Pinho, Paula; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. Corresponding author: Silva, João Pedro. "Identification of key neuronal mechanisms triggered by dimethyl fumarate in SH-SY5Y human neuroblastoma cells through a metabolomic approach". Archives of Toxicology (2024):
    In press
  9. Silva, João Pedro. Corresponding author: Silva, João Pedro. "Health services for substance use disorders: challenges and future perspectives". BMC Health Services Research 23 1 (2023): http://dx.doi.org/10.1186/s12913-023-10072-y.
    10.1186/s12913-023-10072-y
  10. Silva, João Pedro; Carvalho, Félix. Corresponding author: Silva, João Pedro. "Drugs of abuse and epigenetics: Past, present and future". Adicciones 35 3 (2023): 219-226.
    Published • 10.20882/adicciones.2006
  11. Almeida, Ana Sofia; Silva, Bárbara; Silva, João Pedro; Pereira, José Augusto; Remião, Fernando; Fernandes, Carla. "Semi-Preparative Separation, Absolute Configuration, Stereochemical Stability and Effects on Human Neuronal Cells of MDPV Enantiomers". Molecules 28 5 (2023): 2121. http://dx.doi.org/10.3390/molecules28052121.
    10.3390/molecules28052121
  12. Marques, Sandra I.; Carmo, Helena; Carvalho, Félix; Sá, Susana I.; Silva, João Pedro. Corresponding author: Silva, João Pedro. "A Semi-Automatic Method for the Quantification of Astrocyte Number and Branching in Bulk Immunohistochemistry Images". International Journal of Molecular Sciences 24 5 (2023): 4508. http://dx.doi.org/10.3390/ijms24054508.
    10.3390/ijms24054508
  13. Roque-Bravo, Rita; Silva, Rafaela Sofia; Malheiro, Rui F.; Carmo, Helena; Carvalho, Félix; da Silva, Diana Dias; Silva, João Pedro. Corresponding author: Silva, João Pedro. "Synthetic Cannabinoids: A Pharmacological and Toxicological Overview". Annual Review of Pharmacology and Toxicology 63 1 (2023): http://dx.doi.org/10.1146/annurev-pharmtox-031122-113758.
    10.1146/annurev-pharmtox-031122-113758
  14. Malheiro, Rui Filipe; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. Corresponding author: Silva, João Pedro. "Cannabinoid-mediated targeting of mitochondria on the modulation of mitochondrial function and dynamics". Pharmacological Research 187 (2023): 106603. http://dx.doi.org/10.1016/j.phrs.2022.106603.
    10.1016/j.phrs.2022.106603
  15. Silva, João Pedro; Felix Carvalho. Corresponding author: Silva, João Pedro. "The therapeutic use of cannabis and cannabinoids (INVITED)". Revista Española de Drogodependencias 47 4 (2022): 123-141. http://dx.doi.org/10.54108/10032.
    10.54108/10032
  16. Armocida, Benedetta; Silva, João Pedro; Beran, David; et al.. "Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019". The Lancet Child & Adolescent Health 6 6 (2022): 367-383. http://dx.doi.org/10.1016/s2352-4642(22)00073-6.
    Published • 10.1016/s2352-4642(22)00073-6
  17. Castelpietra, Giulio; Silva, João Pedro; et al.. "The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990–2019: Findings from the Global Burden of Disease Study 2019". The Lancet Regional Health - Europe 16 (2022): 100341. http://dx.doi.org/10.1016/j.lanepe.2022.100341.
    10.1016/j.lanepe.2022.100341
  18. Tyrovolas, Stefanos; Silva, JP; et al.. "Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study". BMJ (2022): e068208. http://dx.doi.org/10.1136/bmj-2021-068208.
    10.1136/bmj-2021-068208
  19. Silva, João Pedro; Carmo, Helena; Carvalho, Félix. Corresponding author: Silva, João Pedro. "Drugs of abuse and kidney toxicity (INVITED)". Current Opinion in Toxicology (invite-only) 32 (2022): 100360.
    Open access • Published • 10.1016/j.cotox.2022.100360
  20. Ledesma, Jorge R; ...; Silva, João Pedro; Kyu, Hmwe H.; et al.. "Global, regional, and national sex differences in the global burden of tuberculosis by HIV status, 1990–2019: results from the Global Burden of Disease Study 2019". The Lancet Infectious Diseases 22 2 (2022): 222-241. http://dx.doi.org/10.1016/s1473-3099(21)00449-7.
    Published • 10.1016/s1473-3099(21)00449-7
  21. Nichols, Emma; ...; Silva, João Pedro; Vos, Theo; et al.. "Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019". The Lancet Public Health 7 2 (2022): e105-e125. http://dx.doi.org/10.1016/s2468-2667(21)00249-8.
    Published • 10.1016/s2468-2667(21)00249-8
  22. Silva, João Pedro; Dias da Silva, Diana; Carmo, Helena; Carvalho, Félix. "Neurotoxicity of psychoactive substances: A mechanistic overview". Current Opinion in Toxicology 28 (2021): 76-83. http://dx.doi.org/10.1016/j.cotox.2021.10.002.
    Published • 10.1016/j.cotox.2021.10.002
  23. Rita Roque Bravo; Helena Carmo; Maria João Valente; João Pedro Silva; Félix Carvalho; Maria de Lourdes Bastos; Diana Dias da Silva. "4-Fluoromethamphetamine (4-FMA) induces in vitro hepatotoxicity mediated by CYP2E1, CYP2D6, and CYP3A4 metabolism". Toxicology 463 (2021): 152988-152988. https://doi.org/10.1016/j.tox.2021.152988.
    Published • 10.1016/j.tox.2021.152988
  24. Ward, Joseph L; Silva, João Pedro; Viner, RM; et al.. "Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019". The Lancet 398 10311 (2021): 1593-1618. http://dx.doi.org/10.1016/s0140-6736(21)01546-4.
    10.1016/s0140-6736(21)01546-4
  25. Paulson, Katherine R; ...; Silva, João Pedro; Kassebaum, Nicholas J.; et al.. "Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019". The Lancet 398 10303 (2021): 870-905. http://dx.doi.org/10.1016/s0140-6736(21)01207-1.
    Accepted • 10.1016/s0140-6736(21)01207-1
  26. Nichols, Emma; Silva, João Pedro; Vos, Theo. "Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019". Alzheimer's & Dementia: Translational Research & Clinical Interventions 7 1 (2021): http://dx.doi.org/10.1002/trc2.12200.
    Published • 10.1002/trc2.12200
  27. Slovácková, J; Slavík, J; Kulich, P; Vecera, J; Kovác, O; Paculová, H; Straková, N; et al. "Environmental neurotoxicants affect sphingolipid metabolism in in vitro models of Developmental Neurotoxicity". Toxicology 463 (2021): 152986.
    Open access • Published • 10.1016/j.tox.2021.152986
  28. Reitsma, Marissa B; ...; Silva, João Pedro; Gakidou, Emmanuela; et al.. "Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019". The Lancet 397 10292 (2021): 2337-2360. http://dx.doi.org/10.1016/s0140-6736(21)01169-7.
    Published • 10.1016/s0140-6736(21)01169-7
  29. Kendrick, Parkes J; Reitsma, Marissa B; Silva, João Pedro; Gakidou, Emmanuela; et al.. "Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019". The Lancet Public Health 6 7 (2021): E482-E499. http://dx.doi.org/10.1016/s2468-2667(21)00065-7.
    Open access • Published • 10.1016/s2468-2667(21)00065-7
  30. Lobato-Freitas, Carolina; Brito-da-Costa, Andreia Machado; Dinis-Oliveira, Ricardo Jorge; Carmo, Helena; Carvalho, Félix; Silva, João Pedro; Dias-da-Silva, Diana. Corresponding author: Silva, João Pedro. "Overview of Synthetic Cannabinoids ADB-FUBINACA and AMB-FUBINACA: Clinical, Analytical, and Forensic Implications". Pharmaceuticals 14 3 (2021): 186. http://dx.doi.org/10.3390/ph14030186.
    Open access • 10.3390/ph14030186
  31. Rita Roque Bravo; Helena Carmo; Maria João Valente; João Pedro Silva; Félix Carvalho; Maria de Lourdes Bastos; Diana Dias da Silva. "From street to lab: in vitro hepatotoxicity of buphedrone, butylone and 3,4-DMMC". Archives of Toxicology 95 (2021): 1443-1462. https://doi.org/10.1007/s00204-021-02990-9.
    Published • 10.1007/s00204-021-02990-9
  32. Nichols, Emma; Silva, João Pedro; Vos, Theo; et al.. "The Burden of Dementia due to Down Syndrome, Parkinson’s Disease, Stroke, and Traumatic Brain Injury: A Systematic Analysis for the Global Burden of Disease Study 2019". Neuroepidemiology 55 4 (2021): 286-296. http://dx.doi.org/10.1159/000515393.
    10.1159/000515393
  33. Murray, CJL; Silva, João Pedro; Lim, SS; et al.. "Five insights from the Global Burden of Disease Study 2019". The Lancet 396 10258 (2020): 1135-1159. http://dx.doi.org/10.1016/s0140-6736(20)31404-5.
    Open access • 10.1016/s0140-6736(20)31404-5
  34. Murray, Christopher J. L.; Silva, João Pedro; Lim, Stephen S; et al.. "Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019". The Lancet 396 10258 (2020): 1223-1249. http://dx.doi.org/10.1016/s0140-6736(20)30752-2.
    Open access • 10.1016/s0140-6736(20)30752-2
  35. Vos, Theo; Silva, João Pedro; Murray, Christopher J. L.. "Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019". The Lancet 396 10258 (2020): 1204-1222. http://dx.doi.org/10.1016/s0140-6736(20)30925-9.
    Open access • 10.1016/s0140-6736(20)30925-9
  36. Telma M Gomes; Diana Dias da Silva; Helena Carmo; Félix Carvalho; Silva, João Pedro. Corresponding author: Silva, João Pedro. "Epigenetics and the endocannabinoid system signaling: an intricate interplay modulating neurodevelopment". Pharmacological Research - Special Issue: Portuguese Pharmacology (2020): 105237-105237. http://dx.doi.org/10.1016/j.phrs.2020.105237.
    10.1016/j.phrs.2020.105237
  37. Lozano, Rafael; Fullman, Nancy; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019". The Lancet 396 10258 (2020): 1250-1284. http://dx.doi.org/10.1016/s0140-6736(20)30750-9.
    10.1016/s0140-6736(20)30750-9
  38. Alexandre, João; Malheiro, Rui; Diana Dias daSilva; Helena Carmo; Félix Carvalho; Silva, João Pedro. Corresponding author: Silva, João Pedro. "The Synthetic Cannabinoids THJ-2201 and 5F-PB22 Enhance In Vitro CB1 Receptor-Mediated Neuronal Differentiation at Biologically Relevant Concentrations". International Journal of Molecular Sciences 27 (2020): 6277. http://dx.doi.org/10.3390/ijms21176277.
    Open access • Published • 10.3390/ijms21176277
  39. Silva, João Pedro; Andronis, Christos; Lekka, Eftychia; Virvilis, Vassilis; Carmo, Helena; Bampali, Konstantina; Ernst, Margot; et al. "Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis". Archives of Toxicology 94 8 (2020): 2829-2845. http://dx.doi.org/10.1007/s00204-020-02788-1.
    Published • 10.1007/s00204-020-02788-1
  40. Faria, AC; Carmo, Helena; Carvalho, Félix; Silva, João Pedro; Bastos, ML; Dias da Silva, Diana. "Drinking to death: hyponatraemia induced by synthetic phenethylamines". Drug and Alcohol Dependence 212 (2020): 108045.
    Published
  41. Silva, João Pedro; Lim, Stephen S; et al.. "Global and regional burden of chronic respiratory disease in 2016 arising from non-infectious airborne occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016". Occupational and Environmental Medicine 77 3 (2020): 142-150. http://dx.doi.org/10.1136/oemed-2019-106013.
    10.1136/oemed-2019-106013
  42. Driscoll, Tim R.; ...; Silva, João Pedro; Lim, Stephen S; et al.. "Global and regional burden of disease and injury in 2016 arising from occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016". Occupational and Environmental Medicine 77 3 (2020): 133-141. http://dx.doi.org/10.1136/oemed-2019-106008.
    Published • 10.1136/oemed-2019-106008
  43. Haagsma, Juanita A; James, Spencer L; Silva, João Pedro; et al.. "Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017". Injury Prevention (2020): http://dx.doi.org/10.1136/injuryprev-2019-043296.
    Open access • 10.1136/injuryprev-2019-043296
  44. Roque Bravo, Rita; Carmo, Helena; Silva, João Pedro; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Dias da Silva, Diana. "Emerging club drugs: 5-(2-aminopropyl)benzofuran (5-APB) is more toxic than its isomer 6-(2-aminopropyl)benzofuran (6-APB) in hepatocyte cellular models". Archives of Toxicology (2019): http://dx.doi.org/10.1007/s00204-019-02638-9.
    10.1007/s00204-019-02638-9
  45. Burstein, Roy; Henry, Nathaniel J.; Collison, Michael L.; Marczak, Laurie B.; Silva, João Pedro; et al.. "Mapping 123 million neonatal, infant and child deaths between 2000 and 2017". Nature 574 7778 (2019): 353-358. http://dx.doi.org/10.1038/s41586-019-1545-0.
    10.1038/s41586-019-1545-0
  46. Silva, João Pedro. "Biodistribution and metabolic profile of 3,4-dimethylmethcathinone (3,4-DMMC) in Wistar rats through gas chromatography–mass spectrometry (GC–MS) analysis". Toxicology Letters (2019): http://dx.doi.org/10.1016/j.toxlet.2019.10.003.
    10.1016/j.toxlet.2019.10.003
  47. Diana Dias da Silva; Bárbara Ferreira; Rita Roque Bravo; Rita Rebelo; Tomás Duarte de Almeida; Maria João Valente; João Pedro Silva; et al. "The new psychoactive substance 3-methylmethcathinone (3-MMC or metaphedrone) induces oxidative stress, apoptosis, and autophagy in primary rat hepatocytes at human-relevant concentrations". Archives of Toxicology (2019): https://doi.org/10.1007/s00204-019-02539-x.
    10.1007/s00204-019-02539-x
  48. Alexandre, João; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. Corresponding author: Silva, João Pedro. "Synthetic cannabinoids and their impact on neurodevelopmental processes (TOP 10% MOST DOWNLOADED PAPER IN ADDICTION BIOLOGY IN 2019/2020)". Addiction Biology 25 2 (2019): http://dx.doi.org/10.1111/adb.12824.
    10.1111/adb.12824
  49. Silva, João Pedro. "Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016". The Lancet Neurology (2019): http://dx.doi.org/10.1016/s1474-4422(18)30499-x.
    10.1016/s1474-4422(18)30499-x
  50. Silva, João Pedro; Araújo, AM; Pinho, PG; Carmo, Helena; Carvalho, Félix. Corresponding author: Silva, João Pedro. "Synthetic cannabinoids JWH-122 and THJ-2201 disrupt endocannabinoid-regulated mitochondrial function and activate apoptotic pathways as a primary mechanism of in vitro nephrotoxicity at in vivo relevant concentrations". Toxicological Sciences (2019): http://dx.doi.org/10.1093/toxsci/kfz050.
    In press • 10.1093/toxsci/kfz050
  51. Naghavi, Mohsen; Silva, João Pedro; et al.. "Global, regional, and national burden of suicide mortality 1990 to 2016: systematic analysis for the Global Burden of Disease Study 2016". BMJ (2019): l94. http://dx.doi.org/10.1136/bmj.l94.
    10.1136/bmj.l94
  52. Silva-Carvalho, Ricardo; Silva, João Pedro; Ferreirinha, Pedro; Leitão, Alexandre F.; Andrade, Fábia K.; da Costa, Rui M. Gil; Cristelo, Cecília; et al. "Inhalation of Bacterial Cellulose Nanofibrils Triggers an Inflammatory Response and Changes Lung Tissue Morphology of Mice". Toxicological Research 35 1 (2019): 45-63. http://dx.doi.org/10.5487/tr.2019.35.1.045.
    10.5487/tr.2019.35.1.045
  53. Nichols, Emma; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016". The Lancet Neurology 18 1 (2019): 88-106. http://dx.doi.org/10.1016/s1474-4422(18)30403-4.
    10.1016/s1474-4422(18)30403-4
  54. Silva, João Pedro. "Global, regional, and national burden of tuberculosis, 1990–2016: results from the Global Burden of Diseases, Injuries, and Risk Factors 2016 Study.". The Lancet Infectious Diseases (2018):
    10.1016/S1473-3099(18)30625-X
  55. James, Spencer L; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016". The Lancet Neurology 18 1 (2018): 56-58.
    10.1016/S1474-4422(18)30415-0
  56. Murray, Christopher J L; Silva, João Pedro; Lim, Stephen S.; et al.. "Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017". The Lancet 392 10159 (2018): 1995-2051. http://dx.doi.org/10.1016/s0140-6736(18)32278-5.
    10.1016/s0140-6736(18)32278-5
  57. Roth, Gregory A; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017". The Lancet 392 10159 (2018): 1736-1788. http://dx.doi.org/10.1016/s0140-6736(18)32203-7.
    10.1016/s0140-6736(18)32203-7
  58. Stanaway, Jeffrey D; Silva, João Pedro; Gakidou, Emmanuela; Lim, Stephen S; Murray, Christopher J. L.; Abate, Kalkidan Hassen. "Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017". The Lancet 392 10159 (2018): 1923-1994. http://dx.doi.org/10.1016/s0140-6736(18)32225-6.
    10.1016/s0140-6736(18)32225-6
  59. Silva, João Pedro; Dicker, Daniel; Nguyen, Grant; Murray, Christopher J. L.; Abate, Kalkidan Hassen. "Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017". The Lancet 392 10159 (2018): 1684-1735. http://dx.doi.org/10.1016/s0140-6736(18)31891-9.
    10.1016/s0140-6736(18)31891-9
  60. James, Spencer L; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017". The Lancet 392 10159 (2018): 1789-1858. http://dx.doi.org/10.1016/s0140-6736(18)32279-7.
    10.1016/s0140-6736(18)32279-7
  61. Lozano, Rafael; Fullman, Nancy; Silva, João Pedro; Murray, Christopher J. L.; Abbafati, Cristiana. "Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017". The Lancet 392 10159 (2018): 2091-2138. http://dx.doi.org/10.1016/s0140-6736(18)32281-5.
    10.1016/s0140-6736(18)32281-5
  62. Kyu, Hmwe Hmwe; Silva, João Pedro; Murray, CJL; et al.. "Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017". The Lancet 392 10159 (2018): 1859-1922. http://dx.doi.org/10.1016/s0140-6736(18)32335-3.
    10.1016/s0140-6736(18)32335-3
  63. Bettencourt, Ana P.; Castro, Marian; Silva, João Pedro; Fernandes, Francisco; Coutinho, Olga P.; Sousa, Maria J.; Proenca, M. Fernanda; Areias, Filipe M.. "Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship". Medicinal Chemistry 14 (2018): http://dx.doi.org/10.2174/1573406414666181005143431.
    In press • 10.2174/1573406414666181005143431
  64. Bettencourt, Ana; Castro, Marián; Silva, João Pedro; Fernandes, Francisco; Coutinho, Olga; Sousa, M.; Proença, M.; Areias, Filipe. "New Nitrogen Compounds Coupled to Phenolic Units with Antioxidant and Antifungal Activities: Synthesis and Structure–Activity Relationship". Molecules 23 10 (2018): 2530. http://dx.doi.org/10.3390/molecules23102530.
    10.3390/molecules23102530
  65. Fullman, Nancy; Silva, João Pedro; Murray, Christopher J. L.; Abbafati, Cristiana. "Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016". The Lancet 391 10136 (2018): 2236-2271. http://dx.doi.org/10.1016/s0140-6736(18)30994-2.
    10.1016/s0140-6736(18)30994-2
  66. Silva, João Pedro; Carmo, Helena; Carvalho, Félix. "The synthetic cannabinoid XLR-11 induces in vitro nephrotoxicity by impairment of endocannabinoid-mediated regulation of mitochondrial function homeostasis and triggering of apoptosis (CORRESPONDING AUTHOR)". Toxicology Letters 287 (2018): 59-69. http://dx.doi.org/10.1016/j.toxlet.2018.01.023.
    10.1016/j.toxlet.2018.01.023
  67. Fullman, Nancy; Barber, Ryan M; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016". The Lancet 390 10100 (2017): 1423-1459. http://dx.doi.org/10.1016/s0140-6736(17)32336-x.
    10.1016/s0140-6736(17)32336-x
  68. Wang, Haidong; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016". The Lancet 390 10100 (2017): 1084-1150. http://dx.doi.org/10.1016/s0140-6736(17)31833-0.
    10.1016/s0140-6736(17)31833-0
  69. Gakidou, Emmanuela; Silva, João Pedro; Murray, Christopher J. L.; Abate, Kalkidan Hassen. "Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016". The Lancet 390 10100 (2017): 1345-1422. http://dx.doi.org/10.1016/s0140-6736(17)32366-8.
    10.1016/s0140-6736(17)32366-8
  70. Hay, Simon I; Silva, João Pedro; Murray, Christopher J. L.; Abbafati, Cristiana. "Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016". The Lancet 390 10100 (2017): 1260-1344. http://dx.doi.org/10.1016/s0140-6736(17)32130-x.
    10.1016/s0140-6736(17)32130-x
  71. Vos, Theo; ...; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016". The Lancet 390 10100 (2017): 1211-1259. http://dx.doi.org/10.1016/s0140-6736(17)32154-2.
    Published • 10.1016/s0140-6736(17)32154-2
  72. Naghavi, Mohsen; ...; Silva, João Pedro; Murray, Christopher J. L.; et al.. "Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016". The Lancet 390 10100 (2017): 1151-1210. http://dx.doi.org/10.1016/s0140-6736(17)32152-9.
    Published • 10.1016/s0140-6736(17)32152-9
  73. Silva, João Pedro; Appelberg, Rui; Gama, Francisco Miguel. Corresponding author: Silva, João Pedro. "Antimicrobial peptides as novel anti-tuberculosis therapeutics". Biotechnology Advances 34 5 (2016): 924-940. http://dx.doi.org/10.1016/j.biotechadv.2016.05.007.
    10.1016/j.biotechadv.2016.05.007
  74. Silva, João Pedro; Gonçalves, Carine; Costa, César; Sousa, Jeremy; Silva-Gomes, Rita; Castro, António G.; Pedrosa, Jorge; Appelberg, Rui; Gama, F. Miguel. Corresponding author: Silva, João Pedro. "Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment". Journal of Controlled Release 235 (2016): 112-124. http://dx.doi.org/10.1016/j.jconrel.2016.05.064.
    10.1016/j.jconrel.2016.05.064
  75. Padrão, Jorge; Gonçalves, Sara; Silva, João Pedro; Sencadas, Vitor; Lanceros-Méndez, Senentxu; Pinheiro, Ana C.; Vicente, António A.; Rodrigues, Ligia R.; Dourado, Fernando. "Bacterial cellulose-lactoferrin as an antimicrobial edible packaging". Food Hydrocolloids 58 (2016): 126-140. http://dx.doi.org/10.1016/j.foodhyd.2016.02.019.
    10.1016/j.foodhyd.2016.02.019
  76. Silva, João Pedro. "Laccase immobilization on bacterial nanocellulose membranes: antimicrobial, kinetic and stability properties". Carbohydrate Polymers (2016):
    10.1016/j.carbpol.2016.03.009
  77. Gonçalves, Sara; Rodrigues, Inês Patrício; Padrão, Jorge; Silva, João Pedro; Sencadas, Vitor; Lanceros-Mendez, Senentxu; Girão, Henrique; et al. "Acetylated bacterial cellulose coated with urinary bladder matrix as a substrate for retinal pigment epithelium". Colloids and Surfaces B: Biointerfaces 139 (2016): 1-9. http://dx.doi.org/10.1016/j.colsurfb.2015.11.051.
    10.1016/j.colsurfb.2015.11.051
  78. Silva, João P.; Dhall, Sandeep; Garcia, Monika; Chan, Alex; Costa, César; Gama, Miguel; Martins-Green, Manuela. Corresponding author: Silva, João P.. "Improved burn wound healing by the antimicrobial peptide LLKKK18 released from conjugates with dextrin embedded in a carbopol gel". Acta Biomaterialia 26 (2015): 249-262. http://dx.doi.org/10.1016/j.actbio.2015.07.043.
    10.1016/j.actbio.2015.07.043
  79. Silva, João Pedro; Dhall, S.; Silva, J. P.; Liu, Y.; Hrynyk, M.; Garcia, M.; Chan, A.; et al. "Release of insulin from PLGA-alginate dressing stimulates regenerative healing of burn wounds in rats". Clinical Science 129 12 (2015): 1115-1129. http://dx.doi.org/10.1042/cs20150393.
    10.1042/cs20150393
  80. Gonçalves, C.; Silva, João Pedro; Silva, J. P.; Antunes, I. F.; Ferreira, M. F. M.; Martins, J. A.; Geraldes, C. F. G. C.; et al. "Dextrin-Based Nanomagnetogel: In Vivo Biodistribution and Stability". Bioconjugate Chemistry 26 4 (2015): 699-706. http://dx.doi.org/10.1021/acs.bioconjchem.5b00024.
    Published • 10.1021/acs.bioconjchem.5b00024
  81. Gonçalves, Sara; Padrão, Jorge; Rodrigues, Inês Patrício; Silva, João Pedro; Sencadas, Vitor; Lanceros-Mendez, Senentxu; Girão, Henrique; Dourado, Fernando; Rodrigues, Ligia R.. "Bacterial Cellulose As A Support For The Growth Of Retinal Pigment Epithelium". Biomacromolecules (2015):
    10.1021/acs.biomac.5b00129
  82. Padrão, J.; Silva, João Pedro; Rodrigues, L. R.; Dourado, F.; Lanceros-Méndez, S.; Sencadas, V.. "Modifying Fish Gelatin Electrospun Membranes for Biomedical Applications: Cross-Linking and Swelling Behavior". Soft Materials 12 3 (2014): 247-252.
    10.1080/1539445X.2013.873466
  83. Santos, José Carlos; Silva-Gomes, Sandro; Silva, João Pedro; Gama, Miguel; Rosa, Gustavo; Gallo, Richard L.; Appelberg, Rui. "Endogenous cathelicidin production limits inflammation and protective immunity to Mycobacterium avium in mice". Immunity, inflammation and disease 2 1 (2014): 1-12.
    10.1002/iid3.7
  84. Araujo, J.; Padrao, J.; Silva, João Pedro; Dourado, F.; Correia, D. M.; Botelho, G.; Gomez Ribelles, J. L.; Lanceros-Mendez, S.; Sencadas, V.. "Processing and characterization of alpha-elastin electrospun membranes". Applied Physics A-Materials Science & Processing 115 4 (2014): 1291-1298.
    10.1007/s00339-013-7984-9
  85. Leitao, Alexandre F.; Silva, João Pedro; Dourado, Fernando; Gama, Miguel. "Production and Characterization of a New Bacterial Cellulose/Poly(Vinyl Alcohol) Nanocomposite". Materials 6 5 (2013): 1956-1966.
    10.3390/ma6051956
  86. Muller, D.; Silva, João Pedro; Rambo, C. R.; Barra, G. M. O.; Dourado, F.; Gama, F. M.. "Neuronal cells' behavior on polypyrrole coated bacterial nanocellulose three-dimensional (3D) scaffolds". Journal of biomaterials science: Polymer edition 24 11 (2013): 1368-77.
    10.1080/09205063.2012.761058
  87. Leitao, A. F.; Gupta, S.; Silva, João Pedro; Reviakine, I.; Gama, M.. "Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite". Colloids and Surfaces B-Biointerfaces 111 (2013): 493-502.
    10.1016/j.colsurfb.2013.06.031
  88. Andrade, Fabia K.; Silva, João Pedro; Carvalho, Manuela; Castanheira, Elisabete M. S.; Soares, Raquel; Gama, Miguel. "Studies on the hemocompatibility of bacterial cellulose". Journal of Biomedical Materials Research Part A 98A 4 (2011): 554-566.
    10.1002/jbm.a.33148
  89. Ramos, Reinaldo; Silva, João Pedro; Rodrigues, Ana Cristina; Costa, Raquel; Guardao, Luisa; Schmitt, Fernando; Soares, Raquel; et al. "Wound healing activity of the human antimicrobial peptide LL37". Peptides 32 7 (2011): 1469-1476.
    10.1016/j.peptides.2011.06.005
  90. Silva, João Pedro; Machado, Vera; Calhelha, Ricardo; Queiroz, Maria-Joao R. P.; Coutinho, Olga P.. "Di(hetero)arylamines in the benzo b thiophene series as novel potent antioxidants". Drug discoveries & therapeutics 4 4 (2010): 246-56.
    Published
  91. Silva, João P.; Sardao, Vilma A.; Coutinho, Olga P.; Oliveira, Paulo J.. "Nitrogen Compounds Prevent H9c2 Myoblast Oxidative Stress-Induced Mitochondrial Dysfunction and Cell Death (CORRESPONDING AUTHOR)". Cardiovascular Toxicology 10 2 (2010): 152-152.
    10.1007/s12012-010-9067-x
  92. Silva, João Pedro; Coutinho, Olga P.. Corresponding author: Silva, João Pedro. "Free radicals in the regulation of damage and cell death - basic mechanisms and prevention". Drug Discoveries and Therapeutics 4 (2010): 144-167.
    Published
  93. Silva, João Pedro; Gomes, Andreia; Proença, M. Fernanda R. P.; Coutinho, O. P.. Corresponding author: Silva, João Pedro. "Novel nitrogen compounds enhance protection and repair of oxidative DNA damage in a neuronal cell model: Comparison with quercetin". Chemico-biological interactions 181 3 (2009): 3. http://hdl.handle.net/1822/51149.
    10.1016/j.cbi.2009.07.024
  94. Pinto-Basto, Diana; Silva, João P.; Queiroz, Maria-Joao R. P.; Moreno, Antonio J.; Coutinho, Olga P.. "Antioxidant activity of synthetic diarylamines: A mitochondrial and cellular approach". Mitochondrion 9 1 (2009): 17-26.
    10.1016/j.mito.2008.10.001
  95. Silva, João P.; Proença, Fernanda; Coutinho, Olga P.. "Protective role of new nitrogen compounds on ROS/RNS-mediated damage to PC12 cells". Free Radical Research 42 1 (2008): 57-69. http://dx.doi.org/10.1080/10715760701787719.
    10.1080/10715760701787719
  96. Silva, João P.; Gomes, Andreia C.; Coutinho, Olga P.. "Oxidative DNA damage protection and repair by polyphenolic compounds in PC12 cells". European Journal of Pharmacology 601 1-3 (2008): 50-60.
    10.1016/j.ejphar.2008.10.046
  97. Silva, João P.; Areias, Filipe M.; Proença, Fernanda M.; Coutinho, Olga P.. "Oxidative stress protection by newly synthesized nitrogen compounds with pharmacological potential". Life Sciences 78 11 (2006): 1256-1267. http://dx.doi.org/10.1016/j.lfs.2005.06.033.
    10.1016/j.lfs.2005.06.033
Newsletter article
  1. Silva, João Pedro. "The synthetic cannabinoid XLR-11 and the impaired control of mitochondrial function by the endocannabinoid system as its underlying mechanism of nephrotoxicity.", Atlas of Science (www.atlasofscience.org), 2019, https://atlasofscience.org/the-synthetic-cannabinoid-xlr-11-and-the-impaired-control-of-mitochondrial-function-by-the-endocannabinoid-system-as-its-underlying-mechanism-of-nephrotoxicity/.
  2. Silva, João Pedro. "Antimicrobial peptides: the future of tuberculosis therapeutics", Atlas of Science, 2016, http://atlasofscience.org/antimicrobial-peptides-the-future-of-tuberculosis-therapeutics/#more-17957.
  3. Silva, João Pedro. "Antimicrobial peptide-loaded hyaluronic acid nanogels as a new strategy for tuberculosis therapeutics", Atlas of Science, 2016, http://atlasofscience.org/antimicrobial-peptide-loaded-hyaluronic-acid-nanogels-as-a-new-strategy-for-tuberculosis-therapeutics/.
  4. Silva, João Pedro. "Topical administration of an antimicrobial peptide as a new strategy for improved burn wound healing", Atlas of Science, 2015, http://atlasofscience.org/topical-administration-of-an-antimicrobial-peptide-as-a-new-strategy-for-improved-burn-wound-healing/.
Report
  1. Silva, João Pedro. 2023. Critical Review Report on Dipentylone for the 46th World Health Organization (WHO) Expert Committee on Drug Dependence.. ttps://cdn.who.int/media/docs/default-source/46th-ecdd/dipentylone_46th-ecdd_critical-review_public-version.pdf?sfvrsn=fd3973aa_1.
  2. Silva, João Pedro. 2023. Critical Review Report on Butonitazene for the 46th World Health Organization (WHO) Expert Committee on Drug Dependence.. https://cdn.who.int/media/docs/default-source/46th-ecdd/butonitazene_46th-ecdd-critical-review_public-version.pdf?sfvrsn=77ca1954_1.
  3. Silva, João Pedro. 2022. Critical Review Report on Etazene for the 45th World Health Organization (WHO) Expert Committee on Drug Dependence. Geneva: World Health Organization; 2022 (WHO Technical Report Series). https://cdn.who.int/media/docs/default-source/controlled-substances/45th-ecdd/etazene_draft.pdf?sfvrsn=cc970e16_1.
  4. Silva, João Pedro. 2022. Critical Review Report on Etonitazepyne for the 45th World Health Organization (WHO) Expert Committee on Drug Dependence. Geneva: World Health Organization; 2022 (WHO Technical Report Series). https://cdn.who.int/media/docs/default-source/controlled-substances/45th-ecdd/etonitazepyne_draft.pdf?sfvrsn=59b1de_1.
  5. Silva, João Pedro. 2021. Critical Review Report on Eutylone for the 44th World Health Organization (WHO) Expert Committee on Drug Dependence. Geneva: World Health Organization; 2021 (WHO Technical Report Series). https://www.who.int/publications/m/item/eutylone-critical-review-report.
Thesis / Dissertation
  1. Silva, João Pedro. "New synthetic compounds with pharmacological potential: protection against oxidative stress". PhD, Universidade do Minho Centro de Biologia Molecular e Ambiental, 2009.
  2. Silva, João Pedro. "Effect of new nitrogen compounds with pharmacological potential on oxidative stress protection". Master, Universidade do Minho Centro de Biologia Molecular e Ambiental, 2004.
  3. Silva, João Pedro. "Development of growth, cell viability and lipid peroxidation evaluation tests in a fibroblast cell line exposed to nitrogen heterocycles with pharmacological potential". Degree, Universidade do Minho, 2002.

Intellectual property

Patent
  1. Silva, João Pedro; Appelberg, Rui; Pedrosa, Jorge; Castro, Gil; Gama, Miguel. 2017. "Antimicrobial peptide-loaded hyaluronic acid-based formulations for the treatment of infectious diseases".
    Pending
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02 The epigenetic landscape in rat brain is altered by pharmacologically relevant doses of ciprofloxacin 54th Annual Meeting of the Portuguese Society of Pharmacology
(Portugal)
2024/02 Repeated administration of pharmacologically-relevant doses of dimethyl fumarate affects the expression of proteins involved in neurotransmission and immune response in rat brain. 54th Annual Meeting of the Portuguese Society of Pharmacology
(Portugal)
2024/02 Long-term epigenetic effects of psilocybin: role of 5-HT2AR activation. 54th Annual Meeting of the Portuguese Society of Pharmacology
(Portugal)
2024/02 The synthetic cannabinoid AMB-fubinaca induced differential responses in ß-galactosidase activity on different in vitro neuronal models 54th Annual Meeting of the Portuguese Society of Pharmacology
(Portugal)
2024/02 Epigenetic modulation of the in vitro neurodifferentiation of NG108-15 cells by the synthetic cannabinoid THJ-2201 54th Annual Meeting of the Portuguese Society of Pharmacology
(Portugal)
2023/11 The Synthetic Cannabinoids ADB-FUBINACA Modulate Mitochondrial Function and Dynamics at Biologically Relevant Concentrations During In Vitro Neurodifferentiation X International Conference on Novel Psychoactive Substances
(United Arab Emirates)
2023/11 Potential effects of selected synthetic cannabinoids on neuronal senescence: Impact on proliferation and beta-galactosidase activity in SH-SY5Y cells X International Conference on Novel Psychoactive Substances.
(United Arab Emirates)
2023/09 Astrocyte response in rat brain is affected by pharmacologically-relevant doses of pharmaceuticals associated with neuropsychiatric/psychological adverse events 57th Congress of the European Societies of Toxicology (EUROTOX)
(Slovenia)
2023/05 Heroin and tramadol accelerate telomere shortening in SH-SY5Y neuroblastoma cells. 16th IJUP (Meeting of University of Porto’s Young Researchers)
(Portugal)
2023/05 Opioids and accelerated aging (INVITED) XVI Congresso Científico do Núcleo de Estudantes de Farmácia
Associação Académica de Coimbra (Portugal)
2023/02/02 Increased neuronal differentiation of NG108-15 cells induced by the synthetic cannabinoid AMB-FUBINACA is accompanied by disrupted mitochondrial function. 53rd Annual Meeting of the Portuguese Society of Pharmacology
2023/02/02 The Effect of synthetic cannabinoids on viability and proliferation of neuronal in vitro models. 53rd Annual Meeting of the Portuguese Society of Pharmacology,
2023/02 Protracted administration of a pharmacologically relevant dose of paroxetine to rats promotes astrocyte activation in brain regions 53rd Annual Meeting of the Portuguese Society of Pharmacology,
(Portugal)
2022/11/23 The Influence of the Synthetic Cannabinoids AMB-FUBINACA, ADB-FUBINACA, AB-CHMINACA and THJ-2201 on In Vitro Viability and Senescence of SH-SY5Y Cells and Primary Rat Hippocampal Neurons. Lisbon Addictions 2022.
2022/11/23 In vitro toxicity of the synthetic cannabinoids THJ-2201 and ADB-FUBINACA to human astrocytes. Lisbon Addictions 2022
2022/11/23 he synthetic cannabinoids ADB-FUBINACA and THJ-2201 decrease mitochondrial activity and ATP levels during neurodifferentiation of NG108-15 cells. Lisbon Addictions 2022.
2022/10/24 Effects of the synthetic cannabinoid ADB-FUBINACA on the neurodifferentiation of primary hippocampal neurons. IX International Conference on New Psychoactive Substances
2022/10/24 Increased neuronal differentiation of NG108-15 cells promoted by the synthetic cannabinoid AMB-FUBINACA is associated with decreased DNA methylation. IX International Conference on New Psychoactive Substances
2022/09/18 INVITED LECTURE: Improving the preclinical prediction of psychological/psychiatric adverse effects XVIth International Congress of Toxicology
(Maastricht, Netherlands)
2022/09/18 The influence of selected synthetic cannabinoids on in vitro proliferation and viability of neuronal cell models. XVI International Congress of Toxicology
2022/05/18 INVITED LECTURE: An integrated approach to analyzing the molecular basis of mood and cognitive adverse events Encontro Ciência 2022
Fundação para a Ciência e Tecnologia (Lisbon, Portugal)
2022/05/12 In vitro neurotoxicity induced by a set of synthetic cannabinoid receptor agonists in NG108-15 cells. 15th IJUP (Meeting of University of Porto’s Young Researchers)
2022/05/12 The impact of the synthetic cannabinoid AMB-FUBINACA on global DNA methylation during neuronal differentiation of NG108-15 cells. 15th IJUP (Meeting of University of Porto’s Young Researchers)
2022/05/12 In vitro evaluation of telomere length in SH-SY5Y neuroblastoma cells exposed to heroin and tramadol. 15th IJUP (Meeting of University of Porto’s Young Researchers)
2022/04/06 Mitochondrial effects and Caspase-3 activation induced by synthetic cannabinoids in NG108-15 cells. I International Congress of TOXRUN – Toxicology Research Unit of IUCS” and “V International Congress of the Portuguese Association of Forensic Sciences
2022/02/02 Protracted administration of a pharmacologically relevant dose of paroxetine to rats promotes astrocyte activation in brain regions. 53rd Annual Meeting of the Portuguese Society of Pharmacology
2021/10 INVITED LECTURE: Molecular Pathway Analyses of Mood and Cognitive Adverse Events. Safety Pharmacology Society 2021 Annual Meeting (Virtual), Continuous Education Course “CNS Biomarkers of Mood Disorders and Drug Abuse: Where Are We?”
Safety Pharmacology Society
2021/06 Ciprofloxacin decreases global DNA methylation and increases histone H3 acetylation on differentiated SH-SY5Y neuroblastoma cells. (SENIOR AUTHOR) Jornadas Ibéricas de Toxicologia (virtual meeting)
Universidade da Beira Interior (Portugal)
2021/05 The synthetic cannabinoids THJ-2201 and ADB-FUBINACA increase neuronal differentiation and induce epigenetic changes in NG108-15 cells. (SENIOR AUTHOR) 14th IJUP (Meeting of University of Porto’s Young Researchers)
(Porto, Portugal)
2021/02 Release of antidiuretic hormone (ADH) in Wistar rats in response to the administration of methylone and 3,4-DMMC: the gender impact. XLI Annual Meeting of the Portuguese Society of Pharmacology
2021/02 Biodistribution and metabolism of 3,4-dimethylmethcathinone (3,4-DMMC) in Wistar rats XLI Annual Meeting of the Portuguese Society of Pharmacology
2021/02 In vivo hepatotoxic effects in response to the administration of methylone and 3,4-DMMC to Wistar rats XLI Annual Meeting of the Portuguese Society of Pharmacology
2021/02 Neurotoxicity of a set of synthetic cannabinoid receptor agonists in NG108-15 cells (SENIOR AUTHOR) XLI Annual Meeting of the Portuguese Society of Pharmacology
2021/02 Synthetic cannabinoids increase autophagic vacuoles in NG108-15 cells: influence of CB1R activation (SENIOR AUTHOR) XLI Annual Meeting of the Portuguese Society of Pharmacology
2021/02 Varenicline and ciprofloxacin increase global DNA methylation and histone H3 acetylation on differentiated SH-SY5Y neuroblastoma cells. (SENIOR AUTHOR) XLI Annual Meeting of the Portuguese Society of Pharmacology
2020/11 Neurotoxicity of a set of synthetic cannabinoid receptor agonists in NG108-15 cells (SENIOR AUTHOR) 2º Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto (SIFFUP)
2020/10 ADB-FUBINACA enhance in vitro neuronal differentiation, via activation of cannabinoid receptor 1, at in vivo-relevant concentrations. (SENIOR AUTHOR) XL Annual Meeting of the Portuguese Society of Pharmacology, Coimbra
(Portugal)
2020/09 Antidiuretic hormone (ADH) is released in response to the administration of synthetic cathinones in Wistar rats 15th YES (Young European Scientist) Meeting
(Portugal)
2020/09 Biodistribution and metabolic profile of 3,4-dimethylmethcathinone (3,4-DMMC) in Wistar rats 15th YES (Young European Scientist) Meeting
2020/09 The CYP2E1 metabolism increases in vitro hepatotoxicity of the synthetic psychostimulant 4-fluoromethamphetamine (4-FMA) 15th YES (Young European Scientist) Meeting
2020/09 INVITED LECTURE: Synthetic cannabinoids and their impact on neuronal development. Webinar within the Doctoral Program in Biological Sciences Applied to Health
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) (Portugal)
2020/02 The synthetic psychostimulant 4-fluoromethamphetamine (4-FMA) induces in vitro hepatotoxicity via CYP2E1 metabolism. XL Annual Meeting of the Portuguese Society of Pharmacology
(Portugal)
2019/10 Synthetic cannabinoids 5F-PB22 and THJ-2201 promote neuronal differentiation in neuroblastoma cells at biologically relevant concentrations (SENIOR AUTHOR) Lisbon Addictions 2019
(Portugal)
2019/09 Metabolism plays an important role in the in vitro hepatotoxicity of butylone, buphedrone, and 3,4-dimethylmetcathinone (3,4-DMMC). EUROTOX2019
(Helsinki, Finland)
2019 Synthetic cannabinoids 5F-PB22 and THJ-2201 promote neuronal differentiation in neuroblastoma cells at in vivo relevant concentrations. (SENIOR AUTHOR) XLVIX Annual Meeting of the Portuguese Society of Pharmacology
(Portugal)
2018 Assessment of synthetic cannabinoids' effects on neuronal differentiation in a neuroblastoma cell model. (SENIOR AUTHOR) 11th IJUP (Meeting of University of Porto’s Young Researchers)
(Portugal)
2018 Synthetic cannabinoids promote neuronal differentiation in neuroblastoma cells at in vivo relevant concentrations. (SENIOR AUTHOR) XLVIII Annual Meeting of the Portuguese Society of Pharmacology,
(Portugal)
2017 In vitro assessment of nephrotoxicity induced by synthetic cannabinoids. XLVII Annual Meeting of the Portuguese Society of Pharmacology
(Portugal)
2017 Antimicrobial enzyme immobilization in bacterial cellulose. 3rd International Conference on Natural Fibers
(Portugal)
2017 Development of bacterial cellulose wound dressings with controlled delivery of vitamin D3. GluPor - 12th Meeting of the Carbohydrates Group
(Portugal)
2016 Antimicrobial peptide delivery from self-assembling Hyaluronic acid Nanoparticles for tuberculosis treatment. NanoPT2016 – International Iberian Nanotechnology Laboratory
(Portugal)
2016 INVITED LECTURE: Antimicrobial peptide delivery from self-assembling Hyaluronic acid Nanoparticles for tuberculosis treatment Weekly seminars of the Department of Biology, University of Minho
Department of Biology, University of Minho (Portugal)
2016 INVITED LECTURE: Modification of natural polysaccharides for biomedical applications Advanced Course: Biopolymers based on renewable resources: from synthesis to applications (3rd edition)
Department of Biology, University of Minho (Portugal)
2016 INVITED LECTURE: Synthetic cannabinoids in the context of emerging addictive behaviours Cascais Meeting on Addictions (“Encontro de Adições de Cascais”)
A Barragem – Portuguese Association for the Study, Prevention and Treatment of Dependences. (Portugal)
2015 Toxins in third hand cigarette smoke alter the redox balance in the wound tissue resulting in impaired healing. 25th Annual Meeting of the Wound Healing Society SAWC-Spring/WHS Joint Meeting
(United States)
2015 Improved burn wound healing using a bioactive peptide. 7th Bioengineering Congress
(Turkey)
2015 Biomedical applications of human cathelicidin. MicroBiotec'15 - Congress of Microbiology and Biotechnology
(Portugal)
2015 INVITED LECTURE: Administration of an Antimicrobial Peptide released from hydrogel-embedded dextrin conjugates as a new strategy towards improved burn wound healing 4th Meeting of Microbial and Pharmaceutical Biotechnology
(Portugal)
2015 INVITED LECTURE: Biomedical Applications of Antimicrobial Peptides 2nd BiotechHealth Doctoral Programme Symposium
Abel Salazar Institute for Biomedical Sciences/Faculty of Pharmacy, University of Porto (Portugal)
2014 Improved healing of burns with alginate sponge dressings containing insulin encapsulated in PLGA microparticles. 24th Annual Meeting of the European Tissue Repair Society
(United Kingdom)
2014 Bacterial Cellulose as a support for the growth of retinal pigment epithelium 26th European Conference on Biomaterials
(United Kingdom)
2014 INVITED LECTURE: Antimicrobial Peptide (AMP)-releasing hydrogel, via regulation of angiogenesis and inflammation Weekly seminars of the Department of Biology, University of Minho
Department of Biology, University of Minho (Portugal)
2011 Hemocompatibility study of bacterial cellulose. TERMIS-EU Annual Meeting
(Spain)
2011 Desenvolvimento de suportes condutores de celulose bacteriana com polipirrole para aplicações em células neuronais 11º Congresso Brasileiro de Polímeros
(Brazil)
2011 Biocelulose bacteriana: o futuro dos substitutos arteriais? XI Congress of the Portuguese Society for Angiology and Vascular Surgery
(Portugal)
2010 Bacterial cellulose: production and applications. 2nd Meeting of the Institute for Biotechnology and Bioengineering
(Portugal)
2010 INVITED LECTURE: Bacterial Cellulose: Properties and Applications XIII Days of Biological Engineering
(Portugal)
2009 Nitrogen compounds in the prevention of H9c2 myoblast oxidative stress. “Mitochondria: Between Life and Death” – International Courses on Toxicology 2009
(Portugal)
2008 Oxidative DNA damage protection and repair by new synthetic compounds XVIth National Congress of Biochemistry
(Portugal)
2008 INVITED LECTURE: Protective role of newly synthesized nitrogen compounds on oxidative stress induced in a neuronal cell model XII National Meeting of Biology Students
(Portugal)
2007 Protective role of new nitrogen compounds on oxidative DNA damage Workshop Exploring Molecular Approaches to Cancer Research – the comet assay in the evaluation of genotoxicity and chemoprevention by natural compounds
(Portugal)
2006 Organotin cytotoxicity assessed in prokaryotic and eukaryotic cell models 9th International Symposium on Metal Ions in Biology and Medicine
(Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09 - Current Unraveling the effects of synthetic cannabinoids in osteoblast differentiation and proliferation.
Supervisor
 Molecular Bioengineering (Master)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/09 - Current The impact of rimonabant on histone modifications in a neuronal cell model
Supervisor
 Molecular Bioengineering (Master)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/03/01 - Current Unraveling the molecular signatures underlying the neurotoxicity of emerging synthetic cathinones.
Co-supervisor
 M.Sc. in Analytical Toxicology and Clinical Forensics (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2023/03/01 - Current Exploring the molecular pathways involved in the increased neuronal differentiation induced by synthetic cannabinoids.
Supervisor
 M.Sc. in Analytical Toxicology and Clinical Forensics (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2023/03/01 - Current The impact of rimonabant on histone modifications in a neuronal cell model
Supervisor
 Pharmaceutical Sciences (Degree)
Istanbul Atlas Üniversitesi Tip Fakültesi, Turkey
2022/10/01 - Current Epigenetic impact of cannabinoid exposure on neurogenesis: a mechanistic approach
Supervisor
 Ph.D. in Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2022/10/01 - Current Evaluation of the effects of synthetic cannabinoids in osteogenesis
Supervisor
 Analytical Toxicology and Clinical Forensics (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2022/02 - Current Immunohistochemical profiling of neurotoxicity markers induced by pharmaceuticals commonly associated with mood and cognitive adverse events
Supervisor
 Pharmacy
Warszawski Uniwersytet Medyczny Wydzial Farmaceutyczny, Poland
2022 - Current Evaluation of the effects of synthetic cannabinoids in osteogenesis.
Supervisor of Alessandro Volkov
 M.Sc. in Pharmaceutical and Chemical Technologies (Master)
Universidade do Porto Faculdade de Farmácia, Portugal

Università degli Studi di Modena e Reggio Emilia, Italy
2021/10 - Current Assessment of cannabinoid-mediated modulation of DNA methyltransferases
Supervisor of Mariana Almeida
 MSc in Analytical, Clinical and Forensic Toxicology (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2021/10 - Current In vitro evaluation of telomere length in neuronal cells exposed to therapeutic and recreational opioids
Supervisor
 Toxicologia Analítica Clínica e Forense (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2021/09 - Current Neurodevelopmental toxicity induced by exposure to ADB-FUBINACA and AMB-FUBINACA.
Co-supervisor of Carolina Lobato Freitas
 Forensic Sciences (Master)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2021/01 - Current Unraveling the involvement of G Protein-coupled receptors in the onset of mood and cognitive adverse events
Supervisor of Sandra Isabel Marques
 PhD in Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2021 - Current In vitro evaluation of telomere length in neuronal cells exposed to therapeutic and recreational opioids
Supervisor of Ana Rita Henriques
 MSc in Analytical, Clinical and Forensic Toxicology (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2020/12 - Current Synthetic cannabinoids as a tool for unravelling the mechanisms involved in aging and age-related neurodegenerative diseases
Co-supervisor of Rita Roque da Silva Bravo
 Neurociências (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2020/12 - Current Assessment of the impact of Synthetic Cannabinoids in the neuron-glia cell communication during neuronal development
Supervisor of Rafaela Silva
 Ciências Forenses (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2020/12 - Current In vitro assessment of the Synthetic Cannabinoids’ impact on mitochondrial function and dynamics during neurodevelopment
Supervisor of Rui Filipe Cerqueira Malheiro
 PhD in Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2020 - Current Assessment of cannabinoid-mediated modulation of DNA methyltransferases
Supervisor
 Toxicologia Analítica Clínica e Forense (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2024/02 - 2024/07 Implementation of an ex vivo skin photoaging model.
Supervisor
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
2023/09/04 - 2024/02/07 Immunohistochemical profiling of epigenetic changes in the brain of rats administered pharmaceuticals associated with mood and cognitive adverse effects.
Supervisor
 Pharmaceutical Sciences (Master)
Università degli Studi di Catania, Italy
2023/10 - 2024/02 Assessment of the impact of synthetic cannabinoids on interleukin signaling in primary hippocampal cultures, during neurodifferentiation
Supervisor
Universidade do Porto Faculdade de Farmácia, Portugal
2023/09/13 - 2024/01/19 The impact of rimonabant on histone modifications in a neuronal cell model.
Supervisor
Universidad San Jorge Facultad de Ciencias de la Salud, Spain

Universidade do Porto Faculdade de Farmácia, Portugal
2023/10 - 2024 Assessment of the impact of synthetic cannabinoids on the communication between astrocytes and neurons during neurodevelopment
Supervisor
Universidade do Porto Faculdade de Farmácia, Portugal
2022/10/01 - 2023/10 The impact of new synthetic cannabinoids in circulating dendritic cells
Co-supervisor
 Molecular and Translational Neuroscience (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/09/01 - 2023/01/07 Immunohistochemical evaluation of neurotoxicity markers induced by pharmaceuticals associated with neuropsychiatric/psychological adverse events
Supervisor
 Pharmacy (Degree)
Masarykova univerzita, Czech Republic
2022/02 - 2022/08 Evaluation of the effects of the synthetic cannabinoids XLR-11 and ADB-FUBINACA in the differentiation of MC3T3-E1 cells into osteoblasts.
Supervisor
 Pharmaceutical and Chemical Technologies (Master)
Università degli Studi di Modena e Reggio Emilia, Italy
2021/10/04 - 2021/12/22 In vitro evaluation of synthetic cannabinoids on mitochondrial dynamics
Supervisor
 Pharmacy (Degree)
Università degli Studi di Sassari, Italy
2021/10/04 - 2021/12/22 Evaluation of neurotoxicity markers of pharmaceuticals commonly associated with mood and cognitive adverse events
Supervisor
 Pharmacy (Degree)
Università degli Studi di Sassari, Italy
2020 - 2021/12 Crosstalk between autophagic intermediaries in neurotoxicity induced by Synthetic Cannabinoids
Co-supervisor
 Medicina Legal (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/01/01 - 2021/03/31 Assessment of signaling pathways triggered by the synthetic cannabinoids ADB-FUBINACA and AMB-FUBINACA during neuronal differentiation
Supervisor
 Clinical Pharmacology (Other)
Universidade do Porto Faculdade de Farmácia, Portugal

Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
2021/01/02 - 2021/02/28 In vitro evaluation of mitochondrial function impairment by synthetic cannabinoids during neuronal differentiation
Supervisor of Catarina Dias Santos
 Internship (Other)
Centro Hospitalar Universitário Lisboa Norte EPE, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
2020/11/01 - 2020/12/31 Evaluation of neurotoxicity of synthetic cannabinoids
Supervisor of Luísa Prada
 Internship (Other)
Centro Hospitalar Universitário Lisboa Norte EPE, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
2020/10 - 2020/12 Unraveling the signaling pathways triggered by the synthetic cannabinoids THJ-2201 and 5F-PB22 during neuronal differentiation.
Supervisor
 Clinical Pharmacology (Other)
Universidade do Porto Faculdade de Farmácia, Portugal

Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
2019/11 - 2020/12 Insights into the cell death mechanisms of synthetic cannabinoids in NG108-15 cells
Co-supervisor
 MSc in Forensic Sciences (Master)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/10 - 2020/12 Evaluation of epigenetic modifications induced by synthetic cannabinoids during in vitro neuronal differentiation
Supervisor of Telma Marisa Gomes
Analytical Toxicology and Clinical Forensics (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2019/11 - 2020/11 Assessment of the effects of heroin on telomere length
Supervisor of Lina Solange Matos
 Medicina Legal (Master)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2020 Bacterial cellulose wound dressings
Co-supervisor
 Biomedical Engineering (PhD)
Universidade do Minho, Portugal
2019/06 - 2019/07 Assessment of Synthetic Cannabinoids’ neurotoxicity and their role in neuronal differentiation
Supervisor of Oscar Shirlaw
 ERASMUS+ (Scientific initiation)
Universidade do Porto Faculdade de Farmácia, Portugal

Strathclyde Institute of Pharmacy and Biomedical Sciences, United Kingdom
2019/02 - 2019/07 ASSESSMENT OF THE MODULATION OF THE ENDOCANNABINOID SYSTEM BY SYNTHETIC CANNABINOIDS DURING IN VITRO NEURONAL DIFFERENTIATION
Supervisor of Myrto Galani
 Biochemistry and Biotechnology (Master)
Universidade do Porto Faculdade de Farmácia, Portugal

University of Thessaly, Greece
2018/03 - 2018/07 Evaluation of synthetic cannabinoids' neurotoxicity
Co-supervisor of Busra Altin
Pharmaceutical Toxicology (Other)
Universidade do Porto Faculdade de Farmácia, Portugal

Hacettepe Üniversitesi, Turkey
2017/11 - 2018/02 Assessment of the effects of synthetic cathinones in neuronal differentiation
Supervisor
 Pharmaceutical Sciences (Degree)
Universidade do Porto Faculdade de Farmácia, Portugal

Instituto Politécnico da Guarda, Portugal
2017 - 2018 Assessment of synthetic cannabinoids' effects on neuronal differentiation
Supervisor of João André da Costa Alexandre
 Analytical Toxicology and Clinical Forensics (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2017 - 2018 Exploring the mechanisms involved in an Antimicrobial Peptide response to mycobacterial infections in macrophages
Co-supervisor of Cecília Cristelo
 Molecular Genetics (Master)
Universidade do Minho, Portugal
2016 - 2016 Bacterial cellulose wound dressings
Co-supervisor of Ana Cristina da Costa Rodrigues
 Engenharia Biomédica (PhD)
Universidade do Minho, Portugal
2015 - 2016 Bacterial Cellulose as a drug delivery system for wound healing
Co-supervisor of Beatriz Cardoso
Biomedical Engineering (Master)
Universidade do Minho, Portugal
2011/02 - 2011/07 Synthesis and determination of the antioxidant action of phenolic derivatives using the deoxyribose method
Co-supervisor of Ana Cláudia Ribeiro Leite
 Biochemistry (Degree)
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal

Universidade do Minho Centro de Química, Portugal
2009 - 2010 Effect of novel synthetic di(hetero)diarylamines on the prevention of damage and cell death
Co-supervisor of Vera Alexandra Pereira Machado
 Molecular Genetics (Master)
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019 - 2019 XLVIX Annual Meeting of the Portuguese Society of Pharmacology (2019/02/06 - 2019/02/08)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2007 - 2007 Post-graduation course “Exploring Molecular Approaches to Cancer Research – the comet assay in the evaluation of genotoxicity and chemoprevention by natural compounds” (2007/05/01 - 2007/05/04)
Workshop (Member of the Organising Committee)
 Universidade do Minho, Portugal
2006 - 2006 II Mycological Days. (2006/10 - 2006/10)
Meeting (Member of the Organising Committee)
 Associação Aventura da Saúde, Portugal
2001 - 2001 III Applied Biology Days (2001/11/12 - 2001/11/13)
Meeting (Member of the Organising Committee)
 Universidade do Minho, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/02 - Current Successfully completed the Teaching Module "Introduction to pedagogical practice in Higher Education"
Other
 Formative Cycle of the University of Porto - Introduction to University Teaching
Universidade do Porto, Portugal
2022 - Current Successfully completed the Teaching Module "Gamification of Learning" Formative Cycle of the University of Porto - Introduction to University Teaching
Universidade do Porto, Portugal
2022 - Current Successfully completed the Teaching Module "Academic Integrity and Plagiarism"
Other
 Formative Cycle of the University of Porto - Introduction to University Teaching
Universidade do Porto, Portugal
2022 - Current Successfully completed the Teaching Module "Interculturality and Accessibility in Inclusive Processes"
Other
 Formative Cycle of the University of Porto - Introduction to University Teaching
Universidade do Porto, Portugal
2022 - Current Successfully completed the Teaching Module "Lecture Capture"
Other
 Formative Cycle of the University of Porto - Introduction to University Teaching
Universidade do Porto, Portugal
2016 - Current Best Practice and Alternatives to Animal Experiments in Education and Training
Symposium
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2008 - Current 5th Training Course on Concepts and Methods in Programmed Cell Death
Workshop
Inselspital Universitätsspital Bern, Switzerland
2015/06 - 2015/06 Open Innovation and Intellectual Property Management in Health/Life Sciences – Health-2-Market: From Health Research to Business
Seminar
Startup Braga, Portugal
2015/03 - 2015/03 Management of Intellectual Property and Regulatory Affairs in Translation and Clinical Research
Workshop
Health Cluster Portugal, Portugal
2015 - 2015 3rd Clinical Research Training
Other
Clinical Academic Centre (2CA-Braga), Portugal
2014/11 - 2014/11 Project Management course
Other
University of Minho Alumni Association (AAEUM), Portugal
2013/10 - 2014/01 Introduction to Finance - online course authorized by the University of Michigan and taught by Prof. Gautam Kaul, Professor in Finance from the University of Michigan
Other
University of Michigan, United States

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/01 Modelos animais de laboratório para estudo da Perturbação de Hiperatividade e Défice de Atenção (PHDA)
(Thesis) Arguer
 Patrícia Maria Soares Ferreira Couto (Other)
Universidade do Porto Faculdade de Farmácia, Portugal
2023/07 The role of glia cells in neurotoxicology
(Thesis) Arguer
 Maria Miguel Balsemão Barbosa de Azevedo (Other)
Universidade do Porto Faculdade de Farmácia, Portugal
2023/02/24 Dextrin: a platform for the development of drug delivery systems.
(Thesis) Main arguer
 Fátima Alexandra Meira Machado (PhD)
Universidade do Minho, Portugal
2021/12 Peixe-aranha, uma dor enterrada na areia
(Thesis) Main arguer
 Vítor Manuel Pinto de Sousa Lopes (Other)
Universidade do Porto Faculdade de Farmácia, Portugal
2021 Cannabis and Schizophrenia: Is there a link? A Systematic Review.
(Thesis) Main arguer
 Ana Margarida Pina Águas (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/12 Evaluation of epigenetic modifications induced by synthetic cannabinoids during in vitro neuronal differentiation
Supervisor
 Telma Marisa Gomes (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2020/11 Assessment of the effects of heroin on telomere length
Supervisor
 Lina Solange Matos (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2020/02/19 NEUROTOXIC EFFECTS OF A SET OF SYNTHETIC CANNABINOID RECEPTOR AGONISTS IN NG108-15 CELLS
(Thesis) Main arguer
 Maria Rita Branco Garcia (Other)
Universidade do Porto Faculdade de Farmácia, Portugal
2020 The cognitive dysfunction and neurologic deficits caused by anticancer drugs: a systematic review
(Thesis) Main arguer
 Ana Rita Constantino Dias de Carvalho (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2020 Combination effects of Polycyclic Aromatic Hydrocarbons (PAHs) ubiquitous in the environment – A metabolomic approach
(Thesis) Main arguer
 Ana Cristina Monteiro Pinto (Master)
2018 Synthetic Cannabinoids in the regulation of neuronal differentiation
Supervisor
 João André da Costa Alexandre (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2018 Bacterial Cellulose: a hemostatic material acting as drug delivery system
(Thesis) Main arguer
 Eugénia Queirós (Other)
Universidade do Minho, Portugal
2018 Exploring the molecular mechanisms involved in macrophage’s response to the antimicrobial peptide LLKKK18
Supervisor
 Cecília Silva Cristelo (Master)
Universidade do Minho, Portugal
2017 HEPATOTOXICITY OF 3-METHYLMETHCATHINONE (3-MMC)
(Thesis) Main arguer
 Rita Rebelo. 2017. (Other)
Universidade do Porto Faculdade de Farmácia, Portugal
2016 Polyssacharide-based nanogels: Novel tackling and treating approach of non-small cancer lung cells
(Thesis) Arguer
 Sílvia Marlene Almeida Santos Pedrosa (PhD)
Universidade do Minho, Portugal
2016 Osteogenic differentiation of mesenchymal stem cells by peptides from the pro domain region of the BMP-7
(Thesis) Main arguer
 Clara Beatriz Lopes Barros Menezes Carvalho (Master)
Universidade do Minho, Portugal
2016 Detection and identifications of chemical compounds resulting from burned products containing synthetic cannabinoids
(Thesis) Main arguer
 Rosa Maria Miranda Correia Matos (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2015 Topography of Aligned PNIPAm Nanogels Determines Cell Motility and Cytoskeleton Architecture
(Thesis) Main arguer
 Joana Maria Gonçalves Freitas. (Master)
Universidade do Minho, Portugal
2014 Development of Vascular Grafts of Bacterial Cellulose
(Thesis) Arguer
 Alexandre Felipe Leitão (PhD)
Universidade do Minho, Portugal
2012 A New Cardiovascular Bioimplant: Development of a Mitral Valve Based on a Textile Tubular Structure
(Thesis) Main arguer
 Ricardo André Mota Ribeiro (Master)
Universidade do Minho, Portugal
2012 Innovative materials from Bacterial Cellulose: from synthesis to application
(Thesis) Main arguer
 Rui César Cardoso de Sousa (Other)
Universidade do Minho, Portugal
2011 Bacterial cellulose/polyvinyl alcohol nanocomposite as a biomaterial for small caliber vascular grafts
(Thesis) Main arguer
 Alexandre Felipe Leitão (Other)
Universidade do Minho, Portugal
2011 Synthesis and determination of the antioxidant action of phenolic derivatives using the deoxyribose method
(Thesis) Main arguer
 Ana Cláudia Ribeiro Leite (Other)
Universidade do Minho, Portugal
2010 Effects of new synthetic di(hetero)arylamines sintéticas in the prevention of cell damage and death
Supervisor
 Vera Alexandra Pereira Machado (Master)
Universidade do Minho, Portugal

Association member

Society Organization name Role
2021/02 - Current Society of Toxicology (SOT) Associate Member
2018 - Current Portuguese Society of Pharmacology Member
2018 - Current EUROTOX (Federation of European Toxicologists & European Societies of Toxicology) Associate
2011 - Current Tissue Engineering and Regenerative Medicine International Society (TERMIS) Member
2000 - 2010 Portuguese Society of Biochemistry Member

Committee member

Activity description
Role 		Institution / Organization
2020/11 - Current Critical Report Reviewer in drug dependence liability evaluation in the World Health Organization (WHO) Expert Committee on Drug Dependence
Advisor / Consultant
 World Health Organization (WHO) Expert Committee on Drug Dependence, Switzerland
2020/01 - Current Member of the extended Expert list of the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA)’s Scientific Committee for the purpose of the assessment of the risks posed by New Psychoactive Substances (NPS).
Advisor / Consultant
 European Monitoring Centre for Drugs and Drug Addiction, Portugal

Consulting

Activity description Institution / Organization
2024/02/07 - Current Guest editor in Special Issue "Latest Review Papers in Molecular Toxicology 2024", 2024 in International Journal of Molecular Sciences.
2023/12 - Current Guest editor in Special Collection on “Toxicology of cannabis and cannabis-based products”, 2024 in Frontiers in Toxicology.
2023/11 - Current Guest editor in Special Issue on “Molecular and Toxicological Profiling of Drugs of Abuse - in Honor of Professor Félix Carvalho”, 2024 in Biomolecules
2023/10 - Current Guest editor in Special Issue on “Advances in Developmental Neurotoxicity”, 2023 in International Journal of Molecular Sciences.
2021/11 - Current Drafting of Critical Review Report on Eutylone for the 44th World Health Organization (WHO) Expert Committee on Drug Dependence. Geneva: World Health Organization; 2021 (WHO Technical Report Series). https://www.who.int/publications/m/item/eutylone-critical-review-report World Health Organization (WHO) Expert Committee on Drug Dependence, Switzerland
2016/12 - Current External Advisor, providing critical intellectual input for data interpretation within the Global Burden of Disease Studies. University of Washington Department of Global Health, United States
2023/05 - 2023/12 Guest editor of Collection on “Health services for substance use disorders”, 2023 in BMC Health Research Services.
2021/01 - 2021/10 Guest editor of the Special Issue on “Psychoactive Substances in Neuronal Development”, published in 2021 in the International Journal of Molecular Sciences.

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/09/01 - Current Teaching staff member of the Curricular Unit in Toxicology and Toxicological Analyses Pharmaceutical Sciences (Licenciatura) Universidade do Porto Faculdade de Farmácia, Portugal
2022/04/01 - Current Curricular Unit of Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) in Medicinal Chemistry Pharmaceutical Chemistry (Mestrado) Universidade do Porto Faculdade de Farmácia, Portugal
2021 - 2022 Teaching staff member of Curricular Unit in Environmental Impact of Medicines Ciências Farmacêuticas (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2021 - 2022 Teaching staff member of Curricular Unit in Toxicology and Toxicological Analyses Ciências Farmacêuticas (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2017 - 2017 Industrial Microbiology Pharmaceutical Sciences (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2016 - 2016 Advanced Course: Biopolymers based on renewable resources: from synthesis to applications (3rd edition) Biopolymers (Curso de mestrado (conclusão do curso de especialização)) Universidade do Minho, Portugal
2008 - 2010 Pharmacology Biotechnology and Bioentrepeneurship in Aromatic and Medicinal Plants (Mestrado) Universidade do Minho, Portugal
2008 - 2009 Pharmacology Molecular Genetics (Mestrado) Universidade do Minho, Portugal
2008 - 2008 Applied Animal Biology Applied Biology (Licenciatura) Universidade do Minho, Portugal
2007 - 2007 Workshop “Exploring Molecular Approaches to Cancer Research – the comet assay in the evaluation of genotoxicity and chemoprevention by natural compounds (Especialização pós-licenciatura) Universidade do Minho, Portugal
2006 - 2006 Fundamentals of Pharmacology Applied Biology (Licenciatura) Universidade do Minho, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021 - Current External Expert Reviewer for the evaluation of transnational research proposals within the “Lead Agency Procedure”. Swiss National Science Foundation, Switzerland.
Evaluator
 Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, Switzerland
2019/02 - Current External Expert Reviewer for the evaluation of Post-Doctoral Fellowship proposals within the LEaDing Fellows programme (joint initiative of three Universities in the Netherlands within a European Union H2020-Marie Sklodowska-Curie COFUND Programme).
Evaluator
 Universiteit Leiden, Netherlands

Erasmus Universiteit Rotterdam, Netherlands

Technische Universiteit Delft, Netherlands
2018/12 - Current External Expert Evaluator of candidates to the BiotechHealth Doctoral Program
Evaluator
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/11 - Current External Expert for the evaluation of Research Grants' proposals within the measure 1.1.1.1 “Industry-Driven Research” of priority axis “Research, development of technologies and innovation” of Operational Programme “Growth and Employment” of the EU Structural and Cohesion Fund 2014-2020 programming period - Central Finance and Contracting Agency of Latvia
Evaluator
 Central Finance and Contracting Agency, Latvia
2020/05/13 - 2020/06/12 Expert reviewer of 20th Call for proposals for the H2020-Innovative Medicines Initiative 2 (IMI2) Joint Undertaking
Evaluator
 European Commission, Belgium
2020/02 - 2020/02 External Expert Reviewer for the evaluation of proposals in the PRELUDIUM-18 - Proposals for funding of research projects conducted by researchers at the beginning of their career in research, who do not hold a doctorate degree, National Science Center, Poland
Evaluator
2019/09/30 - 2019/09/30 External Expert Reviewer for the evaluation of proposals in the PRELUDIUM-17 - Proposals for funding of research projects conducted by researchers at the beginning of their career in research, who do not hold a doctorate degree, National Science Center, Poland
Evaluator
 Narodowe Centrum Nauki, Poland

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2023/01/05 Interview, featuring our work published in the Annual Review of Pharmacology and Toxicology (R Roque-Bravo et al. Annual Rev Pharmacol Toxicol 2023 63:187-209), was given to Knowable Magazine: https://knowablemagazine.org/article/health-disease/2023/scientific-highs-and-lows-cannabinoids Knowable Magazine
2018 Estudo analisa efeitos dos canabinóides sintéticos no desenvolvimento dos fetos” / (“Study analyzes the effects of synthetic cannabinoids in fetal development”) Diário de Notícias
2018 "Estudo analisa efeitos dos canabinóides sintéticos no desenvolvimento dos fetos” / (“Study analyzes the effects of synthetic cannabinoids in fetal development”) SAPO LifeStyle (web magazine)
2018 Estudo analisa efeitos dos canabinóides sintéticos no desenvolvimento dos fetos” / (“Study analyzes the effects of synthetic cannabinoids in fetal development”) TSF (radio / online news)

Journal scientific committee

Journal title (ISSN) Publisher
2023 - Current Discover Toxicology (Editorial Board Member) (3004-8893) Springer Nature
2022 - Current Psychoactives (Editorial Board Member)
2021/02 - Current Frontiers in Molecular Biosciences (Editorial Board Member)
2021 - Current Nature Communications Biology (Reviewer)
2019/09/01 - Current International Journal of Molecular Sciences (Associate Editor) (1422-0067) MDPI AG
2019/05/01 - Current BMC Health Services Research (Editorial Board Member) (1472-6963) Springer (Biomed Central Ltd.)
2019 - Current PLoS ONE (Editorial Board Member) (1932-6203) Public Library of Science
2019 - Current Nanomedicine Nanotechnology Biology and Medicine (Reviewer) (1549-9634) Elsevier
2019 - Current Brazilian Journal of Pharmaceutical Sciences (Reviewer) (1984-8250) SciELO
2019 - Current International Journal of Nanomedicine (Reviewer) (1178-2013) Dove Medical Press
2019 - Current Molecules (Reviewer) (1420-3049) MDPI AG
2019 - Current Frontiers in Molecular Biosciences (Reviewer) (2296-889X) Frontiers Media SA
2019 - Current Frontiers in Cell and Developmental Biology (Reviewer) (2296-634X) Frontiers Media SA
2019 - Current PLoS ONE (Editorial Board Member)
2018 - Current Frontiers in Microbiology (Reviewer) (1664-302X) Frontiers Media SA
2018 - Current Scientific Reports (Reviewer) (2045-2322) Springer Nature
2018 - Current BioMed Research International (Guest-Editor) (2314-6141) Hindawi Limited
2017 - Current Microbial Drug Resistance (Reviewer) (1931-8448) Mary Ann Liebert
2016 - Current Current Medicinal Chemistry (Reviewer) (0929-8673) Bentham Science
2016 - Current Current Proteomics (Reviewer) (1570-1646) Bentham Science
2016 - Current International Journal of Nanomedicine (Reviewer) (1178-2013) Dove Medical Press
2016 - Current Journal of Antimicrobial Chemotherapy (Reviewer) (1460-2091) Oxford University Press
2016 - Current Journal of Controlled Release (Reviewer) (0168-3659) Elsevier
2015 - Current Current Drug Therapy (Reviewer) (1574-8855) Bentham Science
2015 - Current Experimental Biology and Medicine (Reviewer) (1535-3699) SAGE Publications
2014 - Current Journal of Biomaterials Applications (Reviewer) (1530-8022) SAGE Publications
2013 - Current Tissue Engineering (Reviewer) (1076-3279) Mary Ann Liebert
2012 - Current Chemical Papers (Reviewer) (1336-9075) Springer-Verlag
2011 - Current Journal of Photochemistry and Photobiology B Biology (Reviewer) (1011-1344) Elsevier
2010 - Current Basic & Clinical Pharmacology & Toxicology (Reviewer) (1742-7843) Wiley (Blackwell Publishing)
2010 - Current European Journal of Pharmacology (0014-2999) Elsevier
2010 - Current International Journal of Molecular Sciences (Reviewer) (1422-0067) MDPI AG
2010 - Current Toxicology Letters (Reviewer) (0378-4274) Elsevier

Mentoring / Tutoring

Topic Student name
2021 - Current Improving the preclinical prediction of psychological/psychiatric adverse effects Ana Margarida Araújo
2022/07/13 - 2022/12/12 Immunohistochemical profiling of biomarkers of neurotoxicity in rat brain tissue Luara Aparecida Simões
2019 - 2022 Assessment of the modulatory effects of Synthetic Cannabinoids on neuronal development Diana Dias da Silva
2013 - 2015 Bacterial Cellulose as a support for the growth of retinal pigment epithelium Sara Gonçalves
2007 - 2008 Quercetin enhances UVA-induced DNA damage in a rat fibroblast cell line Maria Francisca Castro
2005 - 2006 Evaluation of the antioxidant activity of synthetic diarylamines in the benzo[B]thiophene series Diana Pinto Basto
2004 - 2005 Antioxidant and neuroprotective properties of Scutellaria lateriflora Fábia Silva
2004 - 2005 Anti-UV properties of lipidic extracts of three selected marine microalgae Patrícia Oliveira
2004 - 2005 Antioxidant properties of new heterocycle nitrogen compounds Ana Maria Brito

Other jury / evaluation

Activity description Institution / Organization
2015 - 2017 Evaluation of work plans of selected candidates within the BiotechHealth Doctoral Program Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Distinctions

Award

2020 First prize in the Parallel Oral Sessions Awards in Physiology and Immunology of the 15th YES (Young European Scientist) Meeting (Porto, Portugal, September 2020) awarded to the presentation of the work: RR Bravo, H Carmo, JP Silva, FD Carvalho, ML Bast
15th YES (Young European Scientist) Meeting , Portugal
2017 EUROTOX 2017 Travel Bursary
EUROTOX, Belgium
2016 Honour Mention in the 2016 Bluepharma | University of Coimbra Innovation Award
Bluepharma, Portugal

Universidade de Coimbra, Portugal
2001 University of Minho's Merit Award
Universidade do Minho, Portugal
2000 University of Minho's Merit Award
Universidade do Minho, Portugal

Other distinction

2023 • Listed in the world’s top 2% of most cited researchers in 2022, according to Ioannidis, John P.A. (2023), “October 2023 data-update for "Updated science-wide author databases of standardized citation indicators", Elsevier Data Repository, V6, doi: 10.,
2022 Listed in the world's top 2% of most cited researchers in 2021, according to Ioannidis, John P.A. (2022), doi: 10.17632/btchxktzyw.4
2021 Listed in the world's top 2% of most cited researchers in 2020, according to J Baas, K Boyack, JPA Ioannidis (2021), doi: 10.17632/btchxktzyw.3
2020 Top 10% of most downloaded paper in Addiction Biology in 2018/2019 relative to the publication: JA Alexandre, H Carmo, F Carvalho, JP Silva. 2019. Synthetic cannabinoids and their impact on neuronal development. Addiction Biology. e12824.
John Wiley & Sons, Inc., United Kingdom
2020 Listed in the world's top 2% of most cited researchers in 2019, according to JPA Ioannidis, K Boyack, J Baas (2020). doi: 10.1371/journal.pbio.3000918