José Vitor Oliveira Sereno (731D-59D7-3D6B)

Curriculum Vitae

José Vitor Oliveira Sereno

José (PhD) is the animal vivarium coordinator that contains inside the medical imaging unit. This imaging lab is composed with an ultra-field Magnetic resonance (9.4T), an animal RPC-PET prototype with high resolution (0.5 mm, isotropic) and an ultrasound + photoacoustic + doppler system, and OCT (Optical Coherence Tomography). José finished his PhD in 2015, but before that, in 2014 he moved to ICNAS (Medical Imaging Infrastructure at the University of Coimbra) to start the development of the preclinical area. Currently, he is invited scientist fellowship from Coimbra University. The first publication occurs in 2008 and since then published 57 papers in journal with good impact factor in different areas, such as, neurosciences, molecular imaging, radiology, nuclear medicine imaging, cardiology, nephrology, biomarkers and histopathology. Moreover publish 3 papers in conferences, 64 posters in conferences and 24 abstracts in conferences books and participated in more than 100 oral communications (national and international events). José teach in 2 doctoral programs (FCT program- Portuguese Nuclear Magnetic Resonance Network and Doctoral Programme in Health Sciences from Coimbra University), 3 masters degrees related to molecular imaging (biomedical engineer, biochemistry and cellular biology), and training is laboratory animal science that allow the students to have the certification from National authorities (DGAV) to realize procedures and research in animals. He receives students to do laboratorial rotations (1-month duration), master and PhD students . During the last years, he contacts with more than 200 researchers in their publications and learn a lot about different fields. He complemented his graduation assisting courses of magnetic resonance and PET/CT imaging, microscopy, therapeutics and statistics methods. José received 11 distinctions, that includes best work in the field, best oral communication and best abstract submitted, and best project. Finally, he has experience in meeting organization.

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Identification

Personal identification

Full name: José Vitor Oliveira Sereno

Citation names

Sereno, José Vitor Oliveira
Sereno J

Author identifiers

Ciência ID: 731D-59D7-3D6B
ORCID iD: 0000-0002-9607-6653

Email addresses

josesereno@uc.pt (Professional)

Telephones

Telephone

(+351) 239488510 Ext.: 518582 (Professional)

Addresses

ICNAS - Universidade de Coimbra, Pólo das Ciências da Saúde Azinhaga de Santa Comba, 3000-548, Coimbra, Coimbra, Portugal (Professional)

Websites

https://orcid.org/0000-0002-9607-6653 (Professional)
https://www.linkedin.com/in/jos%C3%A9-sereno/ (Professional)
https://www.instagram.com/sereno.jose6/ (Social media)
https://www.facebook.com/josesereno6 (Social media)

Knowledge fields

Medical and Health Sciences - Health Sciences
Medical and Health Sciences
Medical and Health Sciences
Agrarian Sciences - Veterinary Sciences

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
English	Intermediate (B1)	Advanced (C1)	Intermediate (B1)	Advanced (C1)
French	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)
Spanish; Castilian	Beginner (A1)	Beginner (A1)	Beginner (A1)	Intermediate (B1)

Education

	Degree	Classification
2019/11/21 - 2019/11/21 Concluded	Hyperpolarized Carbon-13 MR Imaging of Neurological Disorders (Outros) Bruker BioSpin MRI GmbH, Germany
2019/11/19 - 2019/11/19 Concluded	The role of PET imaging in immuno-oncology (Outros) IBA RadioPharma Solutions, Belgium
2019/11/06 - 2019/11/06 Concluded	Satellite-workshop on competency assessment (Outros) Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2019/10/25 - 2019/10/25 Concluded	CHILI - Conference on Hybrid Imaging Live (Outros) European Society for Hybrid, Molecular and Translational Imaging, Austria
2019/10/10 - 2019/10/10 Concluded	Use of ultra-high field MRI for in and ex vivo neuroimaging (Outros) Bruker BioSpin MRI GmbH, Germany
2019/09/26 - 2019/09/26 Concluded	Mapping brain functions by fMRI with stimulus driven BOLD and MEMRI techniques (Outros) Bruker BioSpin MRI GmbH, Germany
2019/07/25 - 2019/07/25 Concluded	Low dose and quantitative total body PET/CT for preclinical imaging (Outros) Bruker BioSpin MRI GmbH, Germany
2019/06/05 - 2019/06/05 Concluded	Clinical cardiac PET: successful experience in Groningen (Outros) Universitair Medisch Centrum Groningen Afdeling Radiologie, Netherlands
2019/05/02 - 2019/05/02 Concluded	Rapid, Quantitative CEST Imaging with MRI Fingerprinting (Outros) Bruker BioSpin MRI GmbH, Germany
2019/03/28 - 2019/03/28 Concluded	DTI Connectomics in Mouse Models of Neurological Disorders (Outros) Bruker BioSpin MRI GmbH, Germany
2019/03/26 - 2019/03/26 Concluded	Workshop - Teaming up Academia and Industry (Outros) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019/03/19 - 2019/03/19 Concluded	Humane rodent euthanasia (Outros) PLEXX, Netherlands
2019/03/19 - 2019/03/19 Concluded	Evaluate the effects of Light with Electron Paramagnetic Resonance (EPR) (Outros) Bruker BioSpin MRI GmbH, Germany
2019/03/14 - 2019/03/14 Concluded	Monitoring Cancer Treatments with Immuno-PET (Outros) Bruker BioSpin MRI GmbH, Germany
2018/12/13 - 2018/12/13 Concluded	PET Imaging of metabolic changes in LVH (Outros) Bruker BioSpin MRI GmbH, Germany
2018/12/04 - 2018/12/04 Concluded	Comparing Immunodeficient Mice for Cancer, Immunity, and Transplant Research (Outros) Charles River Laboratories Inc, United States
2018/11/22 - 2018/11/29 Concluded	Boas práticas Laboratoriais - conceitos gerais e aplicação (Good laboratorial practice) (Outros) Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal	20
2018/11/15 - 2018/11/15 Concluded	III simposio Nacional de orgãos responsáveis pelo bem-estar dos animais (Outros) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/11/14 - 2018/11/14 Concluded	workshop on severity classification and reporting under EU directive 2010/63/EU (Outros) Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2018/07/17 - 2018/07/17 Concluded	Cardiovascular disease: applying MRI to study atherosclerosis, the aortic arch and endothelial permeability in small animal models (Outros) Bruker BioSpin MRI GmbH, Germany
2018/05/16 - 2018/05/16 Concluded	O tamanho da amostra no desenho de um estudo de investigação (Outros) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/02/21 - 2018/02/21 Concluded	Formulário para pedido de autorização de projectos de utilização de animais para fins cientificos - procedimentos e severidade (Outros) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/12/14 - 2017/12/14 Concluded	New insights into brain function with molecular and functional MRI of the rodent brain at ultra-high fields (Outros) Bruker BioSpin MRI GmbH, Germany
2017/12/06 - 2017/12/06 Concluded	Imaging of infection and tumors using labelled siderophores (Outros) Bruker BioSpin MRI GmbH, Germany IBA RadioPharma Solutions, Belgium
2017/10/11 - 2017/10/11 Concluded	In-ovo MRI (Outros) Bruker BioSpin MRI GmbH, Germany
2017/06/08 - 2017/06/08 Concluded	In Vivo Tumor Progression Studies - The Relative Strengths of available Imaging Modalities and Reporter Constructs (Outros) Bruker BioSpin MRI GmbH, Germany
2009 - 2015/03/11 Concluded	Ciências da Saúde (Doutoramento) Major in Especialidade: Ciências Biomédicas Universidade de Coimbra Faculdade de Medicina, Portugal "Minimização da nefrotoxidade induzida pelo ciclosforina A através de protocolos de conversão para sirolimus- mecanismos e biomarcadores num modelo animal em rato" (THESIS/DISSERTATION)	Aprovado com distinção e louvor
2015 - 2015 Concluded	Advanced Imaging Course (Curso médio) BRUKER, Germany
2014/05/27 - 2014/05/27 Concluded	Functional Imaging of the Brain, Heart and Kidney: Making Good Use of a Cryo-Cooled RF Coil (Outros) Bruker BioSpin MRI GmbH, Germany
2013 - 2013 Concluded	Laboratory Animal Science (Curso médio) Universidade do Minho, Portugal
2012 - 2012 Concluded	Terapêutica Imunossupressora no Transplante Renal (Curso médio) Sociedade Portuguesa de Nefrologia, Portugal
2012 - 2012 Concluded	4th Course on optical Microscopy Imaging for Biosiences (Curso médio) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2012 - 2012 Concluded	Tratamento Estatístico de Dados com SPSS (Curso médio) Curva de Gauss - Estudos, Formação e Consultoria, Unipessoal Lda, Portugal
2011 - 2011 Concluded	Image processing and analysis in cell physiology (Outros) Universidade de Aveiro, Portugal
2008 - 2009 Concluded	Bioqímica (Mestrado) Universidade da Beira Interior, Portugal "Eficácia de Celecoxibes vs Ácido Acetilsalicílico na prevenção/regressão do carcinoma da bexiga – Estudo em modelo animal experimental (rato Wistar)" (THESIS/DISSERTATION)	17
2008 - 2008 Concluded	Formação Pedagógica Inicial de Formadores (Outros) Conclusão - Estudos e formação, Portugal
2003 - 2008 Concluded	Bioquímica (Licenciatura) Universidade da Beira Interior, Portugal "Caracterização de um Modelo Animal (Rato Wistar) de Indução do Carcinoma da Bexiga. Estudo do Celecoxibe (Celebrex®)" (THESIS/DISSERTATION)	14

Affiliation

Science

	Category Host institution	Employer
2019/07/01 - 2020/12/31	Researcher (Research)	Universidade de Coimbra, Portugal
	Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2017/11/01 - 2019/06/30	Postdoc (Research)	Universidade de Coimbra, Portugal
	Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2016/11/01 - 2017/10/31	Science and Technology Management	Universidade de Coimbra, Portugal

2010/01/01 - 2013/10/31	Researcher (Research)	Universidade de Coimbra, Portugal

Other Careers

	Category Host institution	Employer
2013/11/01 - 2016/10/31	Técnico Superior (Técnico Superior)	Universidade de Coimbra, Portugal

Positions / Appointments

	Category Host institution	Employer
2017/04/01 - Current	Preclinical Imaging Unit coordinator	Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

2017/04/01 - Current	Membro do ORBEA (Orgão de Bem-Estar e Ética Animal) - Animal Welfare and Ethics Body member	Universidade de Coimbra, Portugal
	Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Projects

Contract

	Designation	Funders
2019/09 - Current	Cognitive enhancement in aged brain and vascular dementia in humans through improving neurovascular coupling: a mechanism based approach driven by nitrite and ascorbic acid from diet PTDC/MED-NEU/29099/2017 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Ongoing
2023/03/12 - 2026/03/11	Interação calcitonina-receptor promovida por nanopartículas guiadas por péptidos como uma nova abordagem para tratamento de glioblastoma 10.54499/2022.06174.PTDC Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Laboratório Associado de Sistemas Inteligentes 10.54499/LA/P/0104/2020 Universidade do Minho, Portugal Universidade do Minho Centro ALGORITMI, Portugal Universidade do Porto Centro de Matemática, Portugal Universidade do Porto Laboratório de Inteligência Artificial e Ciência de Computadores, Portugal Universidade NOVA de Lisboa, Portugal Universidade Nova de Lisboa Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e Industrial, Portugal Instituto Politécnico do Cávado e do Ave, Portugal Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal Universidade de Aveiro, Portugal Universidade Nova de Lisboa Centro de Tecnologias e Sistemas, Portugal Universidade de Coimbra, Portugal Universidade de Aveiro Centro de Tecnologia Mecânica e Automação, Portugal Universidade de Coimbra Centro de Informatica e Sistemas, Portugal Universidade do Porto Faculdade de Engenharia, Portugal Universidade do Minho Instituto de Polímeros e Compósitos, Portugal Instituto Politécnico do Porto Grupo de Investigação em Engenharia e Computação Inteligente para a Inovação e o Desenvolvimento, Portugal Universidade de Aveiro Instituto de Engenharia Eletrónica e Informática de Aveiro, Portugal Instituto Politécnico do Porto Centro de Investigação em Sistemas Computacionais Embebidos e de Tempo-Real, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Intelligent Systems Associate Laboratory LA/P/0104/2020 Universidade Nova de Lisboa Centro de Tecnologias e Sistemas, Portugal Universidade de Aveiro Centro de Tecnologia Mecânica e Automação, Portugal Instituto Politécnico do Porto Centro de Investigação em Sistemas Computacionais Embebidos e de Tempo-Real, Portugal Universidade do Minho, Portugal Universidade do Porto Centro de Matemática, Portugal Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Laboratório de Inteligência Artificial e Ciência de Computadores, Portugal Instituto Politécnico do Cávado e do Ave, Portugal Universidade do Minho Centro ALGORITMI, Portugal Universidade Nova de Lisboa Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e Industrial, Portugal Universidade do Minho Instituto de Polímeros e Compósitos, Portugal Universidade de Aveiro Instituto de Engenharia Eletrónica e Informática de Aveiro, Portugal Universidade de Coimbra, Portugal Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal Universidade de Coimbra Centro de Informatica e Sistemas, Portugal Universidade de Aveiro, Portugal Instituto Politécnico do Porto Grupo de Investigação em Engenharia e Computação Inteligente para a Inovação e o Desenvolvimento, Portugal Universidade NOVA de Lisboa, Portugal Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/17 - 2025/01/16	Como administrar macromolecules a células-alvo e ativar terapias para o cancro: Deliver-Detect-Defeat DDD PTDC/QUI-OUT/0303/2021 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2023/03/12 - 2024/09/11	Modulação epigenética da integridade da barreira hematoencefálica para a prevenção da epileptogénese 10.54499/2022.03133.PTDC Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2023/03/01 - 2024/08/31	Novas abordagens terapêuticas para a obesidade baseadas na sinalização dopaminérgica periférica 10.54499/2022.05822.PTDC Universidade de Coimbra, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2023/03/01 - 2024/08/31	O triptofano pré-natal como interveniente principal na disfunção do eixo intestino-cérebro: uma abordagem pré-clínica no transtorno do espectro do autismo 10.54499/2022.01066.PTDC Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2023/03/01 - 2024/08/31	New THerapeutIc strategies for obesity based oN peripheral dopamiNERgic signalling 2022.05822.PTDC Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/03/29 - 2024/03/28	Exossomas radiomarcados: uma ferramenta nanoteranóstica para micrometástases pulmonares no osteossarcoma PTDC/BTM-SAL/4451/2020 Universidade de Coimbra, Portugal CNC.IBILI, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/08/01 - 2022/07/31	A imagem não-invasiva por tomografia de coerência óptica na doença neurodegenerativa: da retinal animal ao cérebro humano. PTDC/EMD-EMD/28039/2017 Universidade de Coimbra, Portugal Universidade Aberta, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/26 - 2022/07/25	Melhoria cognitiva no cérebro idoso e demência vascular em humanos através da funcionalização do acoplamento neurovascular: uma estratégia mecanística molecular promovida por nitrito e ácido ascórbico da dieta PTDC/MED-NEU/29099/2017 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal Centro Hospitalar e Universitário de Coimbra EPE, Portugal Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2015/10 - 2016/12	The changing brain in Alzheimer's disease: is the retina a reliable mirror of disease onset and progression? MB-1049-2015 Science and Technology Management Fellow Associação para a Investigação Biomédica e Inovação em Luz e Imagem, Portugal
2014/04/30 - 2016/06	Evaluation of oxidative stress and mitochondrial dysfunction in animal models and patients of Huntington’s disease using Cu(II)-ATSM PET Mantero Belard MB-29-2013 Other Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Santa Casa da Misericórdia de Lisboa Concluded
2010/01/01 - 2013/11/01	MECHANISMS OF CARDIO-RENAL THERAPY TO MINIMIZE THE USE OF CNIS CYCLOSPORINE A WITH MTOR INHIBITORS SIROLIMUS IN RAT - EFFECT OF DRUGS ANTI-HYPERTENSORS/RENOPROTECTORS SFRH/BD/63962/2009	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Projecto Estratégico - UI 3282 - 2011-2012 PEst-C/SAU/UI3282/2011 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Conference abstract	Ribeiro, S; Fernandes, J; Garrido, Patrícia; Sereno, J; Vala, H; Bronze-da-Rocha, E; Belo, L; et al. "rhuEPO induced-hypertension leads to early renal damage". Paper presented in 51th Congress of ERA-EDTA(European Renal Association - European Dialysis and Transplant Association), Amsterdam, 2014. Published Fernandes, J; Ribeiro, S; Garrido, Patrícia; Sereno, J; Costa, E; Reis, F; Santos-Silva, A. "Regulation of liver and kidney erythropoietin gene expression in a rat model of anemia associated with chronic renal failure". Paper presented in 51th Congress of ERA-EDTA(European Renal Association - European Dialysis and Transplant Association), Amsterdam, 2014. Published Sereno, José Vitor Oliveira; Rodrigues-Santos, Paulo; Vala, Helena; Rocha-Pereira, Petronila; Fernandes, João; Santos-Silva, Alice; Teixeira, Frederico; Reis, Flávio. "Biomarkers of transition from Cyclosporine-induced renal dysfunction to nephrotoxicity". Paper presented in 51th Congress of ERA-EDTA (European Renal Association - European Dialysis and Transplant Association), Amsterdam, 2014. Published Ribeiro, S; Follador, B; Nascimento, H; Fernandes, J; Garrido, P; Vala, H; Sereno, J; et al. "Aging is associated with a decreased in renal function and in iron availability, and with an increased in inflammation status". Paper presented in Encontro Renal 2013, Vilamoura, 2013. Published Melo, F.; Sereno, J.; Mendona, D.; Quintanilha, A.; Miranda, V.; Santos Silva, A.; Nascimento, H.; et al. "PON1 ACTIVITY IN HEMODIALYSIS PATIENTS: GENETIC AND NON-GENETIC FACTORS". Paper presented in 49th Congress of the European-Renal-Association/European-Dialysis-and-Transplant-Association (ERA-EDTA), Paris, FRANCE, 2012. Published Garrido, Patrícia; Fernandes, J; Costa, E; Ribeiro, S; Sereno, J; Mascarenhas-Melo, Filipa; Parada, B; et al. "Erythropoietic response to rhEPO therapy is dependent on the stage of renal failure – an experimental study in nephrectomized rats". Paper presented in Encontro Renal 2012, Vilamoura, 2012. Published Piloto, N.; Teixeira, Helena M.; Teixeira de Lemos, E.; Parada, B.; Garrido, P.; Sereno, J.; Pinto, Angela Filipa; et al. "Erythropoietin doping as cause of sudden death in athletes: an experimental study". Paper presented in Congresso da Academia Internacional de Medicina Legal, Lisboa, 2010. Published Mega, Cristina; Vala, H.; Teixeira de Lemos, E.; Fernandes, Rosa; Garrido, P.; Sereno, J.; Parada, B.; et al. "Utilização de parâmetros quantitativos e semi-quantitativos para avaliação dos Ilhéus de Langerhans num modelo animal de Diabetes Mellitus tipo 2". Paper presented in XV Encontro da Sociedade Portuguesa de Patologia Animal, Viseu, 2010. Published Teixeira-Lemos, E.; Reis, Flávio; Espinhaço, L; Baptista, S.; Pinto, R.; Parada, B.; Piloto, N.; et al. "Adiponectin circulating levels as an emerging biomarker of cardiovascular risk in the portuguese population - a preliminary study". Paper presented in EUROMEDLAB Innsbruck 2009, Innsbruck, 2009. Published Garrido, P.; Reis, Flávio; Costa, Elísio; Parada, Belmiro Ataíde da Costa; Piloto, N.; Sereno, J.; Figueiredo, A.; et al. "Recombinant human erythropoietin therapy has beneficial cardio-renal effects on moderate stages of chronic renal failure in the rat". Paper presented in CONGRESS OF THE EUROPEAN ASSOCIATION FOR CLINICAL PHARMACOLOGY AND THERAPEUTICS, 9th, Edinburgh, Scotland, 2009. Published Parada, B.; Reis, Flávio; Teixeira-Lemos, E.; Sereno, J.; Garrido, P.; Piloto, N.; Mota, A.; Figueiredo, A.; Teixeira, Frederico. "Inhibition of bladder tumor growth by a cyclooxygenase-2 inhibitor and immunosuppression agents in an experimental study". Paper presented in 9th Congress of the European Association for Clinical Pharmacology and Therapeutics, Edinburgh, Scotland, 2009. Published Piloto, N.; Reis, Flávio; Teixeira, Helena M.; Teixeira-Lemos, E.; Parada, B.; Garrido, P.; Sereno, J.; et al. "Recombinant human erythropoietin doping in sports – cardiovascular effects in chronic and acute aerobic exercise in an animal model". Paper presented in 9th Congress of the European Association for Clinical Pharmacology and Therapeutics, Edinburgh, Scotland, 2009. Published Parada, Belmiro Ataíde da Costa; Figueiredo, A.; Reis, F; Nunes, P; Sereno, J; Eufrasio, P.; Garrido, P.; Xavier-Cunha, Maria; Mota, A.. "Antitumoral Properties of a Cyclooxigenase-2 Inhibitor and Immunosuppression Agents on Rat Urinary Bladder Carcinogenesis". Paper presented in Congres de la Société Internationale de Urologie, Shangai, China, 2009. Published • 10.1016/j.urology.2009.07.874 Isvarlal, P; Costa, Elísio; Alves, M; Barbot, Jose. "ANÁLISE DA PRÁTICA TRANSFUSIONAL EM CIRURGIA ORTOPÉDICA". Paper presented in I Simpósio de Imunohemoterapia, Póvoa do Varzim, 2000. Published
Conference paper	Piloto, N.; Teixeira, Helena M.; Teixeira de Lemos, E.; Parada, B.; Garrido, P.; Sereno, J.; Pinto, Angela Filipa; et al. "Erythropoietin doping as cause of sudden death in athletes: an experimental study". Paper presented in Congresso da Academia Internacional de Medicina Legal, Lisboa, 2010. Published Garrido, P.; Reis, Flávio; Costa, Elísio; Parada, Belmiro Ataíde da Costa; Piloto, N.; Sereno, J.; Figueiredo, A.; et al. "Recombinant human erythropoietin therapy has beneficial cardio-renal effects on moderate stages of chronic renal failure in the rat". Paper presented in CONGRESS OF THE EUROPEAN ASSOCIATION FOR CLINICAL PHARMACOLOGY AND THERAPEUTICS, 9th, Edinburgh, Scotland, 2009. Published
Conference poster	Garrido, Patrícia; José Sereno. "Transcriptor factors responsible for EPO gene regulation, triggered by administration of rHuEPO high doses". Paper presented in 51th Congress of ERA-EDTA (European Renal Association - European Dialysis and Transplant Association), 2014. Sereno, José Vitor Oliveira. "Regulation of Liver and Kidney Erythropoietin Gene Expression in a Rat Model of Anemia Associated with Chronic Renal Failure". Paper presented in 51st ERA-EDTA Congres, 2014. Mascarenhas-Melo, Filipa; Sereno, José. "Implication of low HDL-c levels in patients with average LDL-c levels – focus on oxidized LDL, large HDL subpopulation and adiponectin". Paper presented in 4th PF2MUC Symposium - Personalized Medicine: Myth or Reality"; Postdoctoral Forum, 2013. Sereno, José Vitor Oliveira. "Kidney mTOR and Mki67 overexpression as biomarkers of transition from cyclosporine-induced renal dysfunction to nephrotoxicity". Paper presented in 5th Annual Meeting of IBILI, 2013. Sereno, José Vitor Oliveira. "Software for the measurement of rodent brain structure volumes from MRI". Paper presented in 5th Annual Meeting of IBILI, 2013. Sereno, José Vitor Oliveira; Vala, H.; Sereno, J.; Rodrigues-Santos, P; Parada, Belmiro Ataíde da Costa; Teixeira, Frederico; Reis, Flávio. "Immunosupressive therapy optimization applied in transplantation: renal benefits of cyclosporine dose reduction and conversion to sirolimus in a rat model". Paper presented in 25th Europen Congress of Pathology, 2013. Sereno, José Vitor Oliveira. "Cyclosporin-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat.". Paper presented in Encontro Renal 2013, 2013. Ribeiro, S; Sameiro-Faria, M; Melo, F; Sereno, J; Freitas, I; Mendonça, M; Nascimento, H; et al. "PON1 activity in hemodialysis patients: genetic and non-genetic factors". Paper presented in 49th ERA-EDTA Congress, 2012. Mascarenhas-Melo, Filipa; Sereno, José Vitor Oliveira. "New biochemical clinical markers of dyslipidaemia and cardiometabolic risk in type 2 diabetes patients – focus on paraoxonase activity and HDL-c subpopulations". Paper presented in V Workshop Bioquímica Clínica, 2012. Mascarenhas-Melo, Filipa; Sereno, José Vitor Oliveira. "Increased cardiovascular risk in men and postmenopause woman – evidences from non-traditional markers". Paper presented in IV Annual meeting of IBILI, 2012. Garrido, Patrícia; Sereno, José Vitor Oliveira. "Cross-talk between renal aging, inflammation, iron metabolism and erythropoiesis". Paper presented in IV Annual Meeting of IBILI, 2012. Garrido, Patrícia; Sereno, José Vitor Oliveira. "Effects of rhEPO therapy in moderate versus severe renal failure induced by nephrectomy in an animal model". Paper presented in V Clinical Biochemistry Workshop, 2012. Sereno, José Vitor Oliveira. "Cyclosporin-induced nephropathy can be avoided through early conversion to Sirolimus in a rat model.". Paper presented in IV annual Meeting of IBILI, 2012. Sereno, José Vitor Oliveira. "Conversion to sirolimus prevents cyclosporin-induced nephropathy in a rat model". Paper presented in 20th Meeting of the EAU Section of Urological Research, 2012. Sereno, José Vitor Oliveira. "Recombinant human erythropoietin treatment promotes cardiorenal cytoprotection in a rat model of chronic renal failure.". Paper presented in 20th Meeting of the EAU Section of Urological Research, 2012. Sereno, José Vitor Oliveira. "Cardiorenal effects of cyclosporine and sirolimus-based immunosuppressive therapy protocols in an experimental rat model.". Paper presented in Conferência CEF 2012, 2012. Sereno, José Vitor Oliveira; Sereno, J.; Reis, F.; Lemos, E. T.; Teixeira, M.; Mega, C.; Romao, A. M.; et al. "Sirolimus ameliorates cyclosporin-induced nephrotoxicity in a rat model – focus on renal lesions, oxidative stress, inflammation, proliferation and angiogenesis". Paper presented in Encontro Renal 2012, 2012. 10.1007/s00428-012-1284-1 Sereno, José Vitor Oliveira. "The relationship between serum and kidney gene expression in rats treated with calcineurin and mTOR inhibitors: inflammation, proliferation, angiogenesis and oxidative stress markers.". Paper presented in V Clinical Biochemistry Workshop, 2012. Sereno, José Vitor Oliveira. "Immunosuppressive agents impair glucose and lipid metabolism in Wistar rats". Paper presented in V Clinical Biochemistry Workshop, 2012. Mascarenhas-Melo, Filipa; Sereno, José Vitor Oliveira. "Paraoxonase activity and HDL-c subpopulations as markers of dyslipidaemia and cardiometabolic risk in type 2 diabetes patients". Paper presented in III Annual meeting of IBILI, 2011. Mascarenhas-Melo, Filipa; Sereno, José Vitor Oliveira. "Oxidized-LDL as an earlier marker of cardiovascular risk in multiple sclerosis patients – correlation with clinical staging". Paper presented in III Annual meeting of IBILI, 2011. Sereno, J; Romão, AM; Parada, B; Garrido, P; Alves, R; Costa, E; Santos-Silva, A; et al. "Early versus late cyclosporin to sirolimus conversion in an animal model: focus on cardiorenal benefits". Paper presented in 25º Congresso da Sociedade Portuguesa de Nefrologia, 2011. Sereno, José Vitor Oliveira. "Serum and renal tissue markers of inflammation, proliferation, angiogenesis and oxidative stress in rats under immunosuppressive therapy: cyclosporin versus Sirolimus.". Paper presented in 3rd Annual Meeting of IBILI, 2011. Sereno, José Vitor Oliveira. "Erythropoietic response to rhEPO therapy in moderate versus severe renal failure induced by nephrectomy in the rat.". Paper presented in 3rd Annual Meeting of IBILI, 2011. Sereno, José Vitor Oliveira. "Cardiorenal and metabolic side-effects of immunosuppressive agentes in the rat: cyclosporin versus Sirolimus.". Paper presented in Postdoctoral Forum, Faculty of Medicine, University of Coimbra, 2011. Sereno, José Vitor Oliveira. "XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica e X Reunião de Toxicologia". Paper presented in XII Congresso Português de Endocrinologia e 62ª Reunião Anual da SPEDM, 2011. Mascarenhas-Melo, Filipa; Sereno, José Vitor Oliveira. "Effect of antidislipidaemics on paraoxonase activity in patients with type 2 diabetes mellitus". Paper presented in 2nd National Meeting on Medicinal Chemistry /2enqt – SPQ, 2010. Mascarenhas-Melo, Filipa; Sereno, José Vitor Oliveira. "Paraoxonase 1 activity as a predictive cardiovascular risk marker in Type 2 Diabetes". Paper presented in Journées Internationales de Biologie, 2010. Mascarenhas-Melo, Filipa; Sereno, José Vitor Oliveira; Teixeira-Lemos, E.; Mega C; Vala, H; Fernandes R; Oliveira, Jorge; et al. "Rationale for dpp-4 inhibition by sitagliptin in the management of type 2 diabetes". Paper presented in 2nd National Meeting on Medicinal Chemistry /2enqt – SPQ, 2010. Mascarenhas-Melo, Filipa; Sereno, José Vitor Oliveira. "Paraoxonase 1 activity as a new inflammatory marker of cardiometabolic risk in type 2 diabetes mellitus patients". Paper presented in XVII Congresso Nacional de Bioquímica, 2010. Mascarenhas-Melo, Filipa; Sereno, José Vitor Oliveira. "Antidyslipidaemics treatment attenuates paraoxonase activity reduction in type 2 diabetes mellitus patients". Paper presented in Heart, Vessels & Diabetes - The European Conference, 2010. Teixeira, M; Rodrigues-Santos, P; Garrido, P; Costa, E; Parada, B; Sereno, J; Belo, L; et al. "Effect of recombinant human erythropoietin therapy on kidney and heart gene expression profile in a model of moderate chronic renal failure". Paper presented in XVII Congresso Nacional de Bioquímica, 2010. Garrido, P; Reis, F.; Costa, Elísio; Teixeira M; Parada, B; Santos P; Alves, R; et al. "Pleiotropic effects of rhEPO in an animal model of moderate chronic kidney disease". Paper presented in Scientif Workshop "Innovative therapies for red cell and iron related disorders", 2010. Garrido, Patrícia; Sereno, José Vitor Oliveira. "Effect of omega-3 fatty acids as chemopreventive therapy for bladder cancer in a rat model". Paper presented in XVII Congresso Nacional De Bioquímica, 2010. Sereno, José Vitor Oliveira. "Inhibition of bladder tumour growth by chitooligosaccharides in an experimental carcinogenesis model.". Paper presented in XVII Congresso Nacional De Bioquímica, 2010. Sereno, José Vitor Oliveira. "Cardiorenal and metabolic side-effects of immunosuppressive agents in the rat: Cyclosporin versus Sirolimus". Paper presented in II Annual Meeting of IBILI, 2010. Sereno, José Vitor Oliveira; Cerejo, Raquel; Reis, F; Parada, Belmiro Ataíde da Costa; Teixeira de Lemos, E; Sereno, J; Garrido, P; et al. "Omega-3 fatty acids therapy for prevention of nitrosamine-induced bladder cancer in a rat model.". Paper presented in 2nd National Meeting on Medicinal Chemistry /2enqt, 2010. Sereno, José Vitor Oliveira; Garrido, P.; Costa, E.; Parada, Belmiro Ataíde da Costa; Rodrigues-Santos, P; Sereno, J.; Teixeira de Lemos, E.; et al. "Efeitos não hematológicos da eritropoietina num modelo de insuficiência renal induzida por nefrectomia". Paper presented in VIII Congresso de Análise Clínicas e Saúde Pública, 2010. Sereno, José Vitor Oliveira. "Immunosuppressive agents alter glucose metabolism, blood pressure and heart rate in rats". Paper presented in XI International Symposium on Insulin Receptors and Insulin Action, 2010. Mascarenhas-Melo, Filipa; Sereno, José Vitor Oliveira; Teixeira-Lemos, E.; Reis, Flávio; Espinhaço, L; Baptista, S.; Pinto, R.; et al. "Low adiponectin levels and paraoxonase activity as markers of oxidative stress and inflammation in atherosclerosis – study in a portuguese population". Paper presented in 9th Congresso da EACPT (European Association for Clinical Pharmacology and Therapeutics), 2009. Garrido, P; Reis, F.; Costa, Elísio; Parada, B; Teixeira de Lemos, E; Piloto, N; Sereno, J; et al. "Effects of recombinant human erythropoietin therapy on moderate stages of cardio-renal anemia syndrome - an experimental model". Paper presented in Third Congress of the International BioIron Society and the 8th International Symposium on Microbial Iron Transport, Storage and Metabolism, 2009. Garrido, P; Parada, B; Teixeira de Lemos, E; Alves, R; Santos, P; Almeida, A; Costa, Elísio; et al. "Evidences for earlier rh-epo therapy recommendation in chronic kidney disease – anti-apoptotic, anti-inflammatory, antioxidant, pro-proliferative and pro-angiogenic effects in an animal model". Paper presented in 1st Anual Meeting IBILI, 2009. Piloto, N; Reis, F.; Teixeira, HM; Teixeira de Lemos, E; Garrido, P; Costa, Elísio; Sereno, J; et al. "Recombinant human erythropoietin dopping in an experimental model of chronic aerobic exercice trining". Paper presented in Third Congress of the International BioIron Society and the 8th International Symposium on Microbial Iron Transport, Storage and Metabolism, 2009. Garrido, Patrícia; Sereno, José Vitor Oliveira. "Erythropoietin doping as cause of sudden death in athletes – an experimental study". Paper presented in XXI Congresso da IALM (International Academy of Legal Medicine), 2009. Piloto, N; Reis, F.; Teixeira, HM; Teixeira de Lemos, E; Parada, B; Garrido, P; Costa, Elísio; et al. "Doping com rhEPO e risco cardiometabólico – treino crónico versus sessão extenuante". Paper presented in 7.º Congresso nacional de medicina legal, 2008. Garrido, P; Reis, F.; Costa, Elísio; Teixeira de Lemos, E; Parada, B; Piloto, N; Sereno, J; et al. "Effects of rh erythropoietin treatment in an experimental model of moderate renal failure – haematological, biochemical, oxidative and inflammatory profiles". Paper presented in XXXIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica e VIII Reunião de Toxicologia, 2008. Garrido, Patrícia; Sereno, José Vitor Oliveira. "Contribution of adiponectin to low-grade inflammatory state as expressed by circulating C-reactive protein in a Portuguese population: a preliminary study". Paper presented in XVI Congresso Nacional de Bioquímica, 2008. Garrido, Patrícia. "Hypertension induced by immunosuppressive drugs – comparative analysis between sirolimus and cyclosporine". Paper presented in VII Congresso Luso Brasileiro de Transplantação, 2008. Garrido, Patrícia; Reis, Flávio; Parada, B.; Garrido, P.; Sereno, J.; Nunes, P.; Eufrásio, P.; et al. "Pathophysiological mechanisms underlying the cardiovascular side-effects of sirolimus versus cyclosporine". Paper presented in XVI Congresso Nacional de Bioquímica, 2008. Garrido, Patrícia; Sereno, José Vitor Oliveira. "Complicações cardiovasculares do doping continuado com eritropoietina recombinante humana". Paper presented in 7º Congresso Nacional de Medicina Legal, 2008. Garrido, Patrícia; Sereno, José Vitor Oliveira. "HDL-containing paraoxonase activity as a new putative cardiovascular risk marker in dyslipidaemic obese patients". Paper presented in 3º Workshop de Bioquímica Clínica, 2008. Garrido, Patrícia; Sereno, José Vitor Oliveira. "Effects of recombinant human erythropoietin therapy on haematological, biochemical, oxidative and inflammatory profiles in an experimental model of renal failure". Paper presented in XVI Congresso Nacional de Bioquímica, 2008. Garrido, Patrícia; Sereno, José Vitor Oliveira. "Effects of immunosupression on a bladder carcinogenesis model in rats". Paper presented in VII Congresso Luso Brasileiro de Transplantação, 2008. Sereno, José Vitor Oliveira; Garrido, Patrícia. "Cardiovascular effects of recombinant human erythropoietin treatment on a rat experimental animal model of sports doping". Paper presented in XVI Congresso Nacional de Bioquímica, 2008. Sereno, José Vitor Oliveira. "Impairment of antioxidant paraoxonase activity and HDL-c protection in dyslipidaemic/obese patients.". Paper presented in XVI Congresso Nacional de Bioquímica, 2008.
Journal article	Beatriz Caramelo; Tamaeh Monteiro-Alfredo; João Martins; José Sereno; João Castelhano; Bruno Manadas; Miguel Castelo-Branco; Paulo Matafome. "Functional imaging and neurochemistry identify in vivo neuroprotection mechanisms counteracting excitotoxicity and neurovascular changes in the hippocampus and visual cortex of obese and type 2 diabetic animal models". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15825. 10.1111/jnc.15825 Santos, Sofia; Martins, Beatriz; Sereno, José; Martins, João; Castelo-Branco, Miguel; Gonçalves, Joana. "Neurobehavioral sex-related differences in Nf1+/- mice: female show a “camouflaging”-type behavior". Biology of Sex Differences 14 1 (2023): http://dx.doi.org/10.1186/s13293-023-00509-8. 10.1186/s13293-023-00509-8 Almeida, Sara F.F.; Fonseca, Alexandra; Sereno, José; Ferreira, Hugo R. S.; Lapo-Pais, Mariana; Martins-Marques, Tânia; Rodrigues, Teresa; et al. "Osteosarcoma-Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis". Small 18 49 (2022): http://dx.doi.org/10.1002/smll.202203999. 10.1002/smll.202203999 Lopes, Carla; Ferreira, I. Luísa; Maranga, Carina; Beatriz, Margarida; Mota, Sandra I.; Sereno, José; Castelhano, João; et al. "Mitochondrial and redox modifications in early stages of Huntington's disease". Redox Biology 56 (2022): 102424. http://dx.doi.org/10.1016/j.redox.2022.102424. 10.1016/j.redox.2022.102424 Palavra, Filipe; Viana, Sofia D.; Henriques, Sara; Dinis, João; Martins, João; Madeira, Maria H.; Santiago, Raquel; et al. "Defining milestones for the study of remyelination using the cuprizone mouse model: How early is early?". Multiple Sclerosis and Related Disorders 63 (2022): 103886. http://dx.doi.org/10.1016/j.msard.2022.103886. 10.1016/j.msard.2022.103886 Jonatan Dewulf; Ivanna Hrynchak; Sarah Geudens; Isabel Pintelon; Christel Vangestel; José Sereno; Peter A. van Dam; et al. "Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibody Fab Fragments". Pharmaceutics 14 5 (2022): 939-939. https://doi.org/10.3390/pharmaceutics14050939. 10.3390/pharmaceutics14050939 Miranda, Catarina Oliveira; Nobre, Rui Jorge; Paiva, Vitor Hugo; Duarte, João Valente; Castelhano, João; Petrella, Lorena Itatí; Sereno, José; et al. "Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease". Acta Neuropathologica Communications 10 1 (2022): http://dx.doi.org/10.1186/s40478-022-01329-4. 10.1186/s40478-022-01329-4 Ferreira, Helena; Sousa, Ana Catarina; Sereno, José; Martins, João; Castelo-Branco, Miguel; Gonçalves, Joana. "Sex-Dependent Social and Repetitive Behavior and Neurochemical Profile in Mouse Model of Autism Spectrum Disorder". Metabolites 12 1 (2022): 71. http://dx.doi.org/10.3390/metabo12010071. 10.3390/metabo12010071 Basso, João; Mendes, Maria; Silva, Jessica; Sereno, José; Cova, Tânia; Oliveira, Rui; Fortuna, Ana; et al. "Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment". European Journal of Pharmaceutics and Biopharmaceutics 155 (2020): 177-189. http://dx.doi.org/10.1016/j.ejpb.2020.08.015. 10.1016/j.ejpb.2020.08.015 Duarte Lobo, Diana; Nobre, Rui Jorge; Oliveira Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Koeppen, Arnulf; Castelo-Branco, Miguel; Pereira de Almeida, Luís. "The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples". Acta Neuropathologica Communications 8 1 (2020): http://dx.doi.org/10.1186/s40478-020-00955-0. 10.1186/s40478-020-00955-0 Castelhano, Joao; Ribeiro, Bruno; Sanches, Mafalda; Graça, Bruno; Saraiva, Joana; Oliveiros, Bárbara; Neves, Christian; et al. "A rat model of enhanced glycation mimics cardiac phenotypic components of human type 2 diabetes : A translational study using MRI". Journal of Diabetes and its Complications 34 5 (2020): 107554. http://dx.doi.org/10.1016/j.jdiacomp.2020.107554. 10.1016/j.jdiacomp.2020.107554 Oliveira, Sara R.; Castelhano, João; Sereno, José; Vieira, Helena L. A.; Duarte, Carlos B.; Castelo-Branco, Miguel. "Response of the cerebral vasculature to systemic carbon monoxide administration—Regional differences and sexual dimorphism". European Journal of Neuroscience 52 1 (2020): 2771-2780. http://dx.doi.org/10.1111/ejn.14725. 10.1111/ejn.14725 Sereno, José Vitor Oliveira. "Gd- and Eu-Loaded Iron Oxide@Silica Core–Shell Nanocomposites as Trimodal Contrast Agents for Magnetic Resonance Imaging and Optical Imaging". Inorganic Chemistry (2019): http://dx.doi.org/10.1021/acs.inorgchem.9b02655. 10.1021/acs.inorgchem.9b02655 Sereno, José Vitor Oliveira. "Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study". Alzheimer's Research & Therapy (2019): http://dx.doi.org/10.1186/s13195-019-0542-8. 10.1186/s13195-019-0542-8 Sereno, José Vitor Oliveira. "A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss". Human Molecular Genetics (2019): http://dx.doi.org/10.1093/hmg/ddz045. 10.1093/hmg/ddz045 Sereno, José Vitor Oliveira. "Dietary Glycotoxins Impair Hepatic Lipidemic Profile in Diet-Induced Obese Rats Causing Hepatic Oxidative Stress and Insulin Resistance". Oxidative Medicine and Cellular Longevity (2019): http://dx.doi.org/10.1155/2019/6362910. 10.1155/2019/6362910 Banerjee, Arnab; Alves, Vitor; Rondão, Tiago; Sereno, José; Neves, Ângela; Lino, Miguel; Ribeiro, Andreia; et al. "A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles". Nanoscale (2019): http://hdl.handle.net/10316/87318. 10.1039/c9nr02512j Oliveira Miranda C; Marcelo A; Silva TP; Barata J; Vasconcelos-Ferreira A; Pereira D; Nóbrega C; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease.". Molecular therapy : the journal of the American Society of Gene Therapy (2018): http://europepmc.org/abstract/med/30087083. 10.1016/j.ymthe.2018.07.007 Petrella LI; Castelhano JM; Ribeiro M; Sereno JV; Gonçalves SI; Laço MN; Hayden MR; Rego AC; Castelo-Branco M. "A whole brain longitudinal study in the YAC128 mouse model of Huntington's disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes.". Human molecular genetics (2018): http://europepmc.org/abstract/med/29668904. 10.1093/hmg/ddy119 Sereno, José; Ribeiro, Mário; Petrella, L. I.; Castelhano, João; Sereno, José; Rodrigues, Tiago; Neves, Christian; et al. "High-fat diet induces a neurometabolic state characterized by changes in glutamate and N-acetylaspartate pools associated with early glucose intolerance: an in-vivo multimodal MRI study". Journal of Magnetic Resonance Imaging in process (2017): Accepted • 10.1002/jmri.25942 Leitão, Ricardo Alexandre; Sereno, José; Castelhano, João Miguel; Gonçalves, Sónia Isabel; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos; Castelo-Branco, Miguel; Silva, Ana Paula. "Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior". Molecular Neurobiology 55 3 (2017): 2056-2069. http://dx.doi.org/10.1007/s12035-017-0439-0. 10.1007/s12035-017-0439-0 Leitão, Ricardo Alexandre; Sereno, José; Castelhano, João Miguel; Gonçalves, Sónia Isabel; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos; Castelo-Branco, Miguel; Silva, Ana Paula. "Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior". Molecular Neurobiology 1 (2017): 1-14. Published • 10.1007/s12035-017-0439-0 Gonçalves, Joana; Violante, Inês R.; Sereno, José; Leitão, Ricardo A.; Cai, Ying; Abrunhosa, Antero; Silva, Ana Paula; Silva, Alcino J.; Castelo-Branco, Miguel. "Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes". Molecular Autism 8 1 (2017): 47-54. Published • 10.1186/s13229-017-0166-4 Rodrigues, Tiago; Matafome, Paulo; Sereno, José; Almeida, José; Castelhano, João; Gamas, Luís; Neves, Christian; et al. "Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance". Scientific Reports 7 1 (2017): 1698-1710. Published • 10.1038/s41598-017-01730-3 Petrella, L. I.; Cai, Y.; Sereno, J. V.; Gonçalves, S. I.; Silva, A. J.; Castelo-Branco, M.. "Brain and behaviour phenotyping of a mouse model of neurofibromatosis type-1: an MRI/DTI study on social cognition". Genes, Brain and Behavior 15 7 (2016): 637-646. Published • 10.1111/gbb.12305 Sereno J; Vala H; Nunes S; Rocha-Pereira P; Carvalho E; Alves R; Teixeira F; Reis F. "Cyclosporine A-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat.". (2015): http://europepmc.org/abstract/med/25903959. Costa E; Fernandes J; Ribeiro S; Sereno J; Garrido P; Rocha-Pereira P; Coimbra S; et al. "Aging is Associated with Impaired Renal Function, INF-gamma Induced Inflammation and with Alterations in Iron Regulatory Proteins Gene Expression.". Aging and Disease 5 (2014): 0-0. http://europepmc.org/abstract/med/25489488. Published • 10.14366/ad.2014.0500356 Lopes, P.C.; Fuhrmann, A; Carvalho, F; Sereno, J; Santos, MR; Pereira, M.J.; Eriksson, J.W.; Reis, F; Carvalho, E. "Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment". Biochemical Pharmacology 91 1 (2014): 61-73. Published • 10.1016/j.bcp.2014.06.014 Fuhrmann, A.; Lopes, P.; Sereno, J.; Pedro, J.; Espinoza, D.; Pereira, M.J.; Reis, F.; Eriksson, J.W.; Carvalho, E.. "Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model". Biochemical Pharmacology in press (2014): inpress-inpress. Published • 10.1016/j.bcp.2014.01.020 Lopes, Patrícia C.; Fuhrmann, Amelia; Sereno, José; Espinoza, Daniel O.; Pereira, Maria João; Eriksson, Jan W.; Reis, Flávio; Carvalho, Eugenia. "Short and long term in vivo effects of Cyclosporine A and Sirolimus on genes and proteins involved in lipid metabolism in Wistar rats". Metabolism 63 5 (2014): 702-715. Published • 10.1016/j.metabol.2014.02.004 Sereno J; Rodrigues-Santos P; Vala H; Rocha-Pereira P; Alves R; Fernandes J; Santos-Silva A; et al. "Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model.". (2014): http://europepmc.org/abstract/med/24853130. 10.3390/ijms15058979 Sereno, José; Nunes, Sara; Rodrigues-Santos, Paulo; Vala, Helena. "Conversion to sirolimus ameliorates cyclosporine-induced nephropathy in the rat – focus on serum, urine, gene and protein renal expression biomarkers". (2014): http://hdl.handle.net/10400.19/2180. 10.1155/2014/576929 Sereno J; Parada B; Rodrigues-Santos P; Lopes PC; Carvalho E; Vala H; Teixeira-Lemos E; et al. "Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: cyclosporine versus sirolimus.". Transplantation proceedings 45 3 (2013): 1149-11. http://europepmc.org/abstract/med/23622648. Published • 10.1016/j.transproceed.2013.02.085 Lopes, P.; Fuhrmann, A.; Sereno, J.; Pereira, M.J.; Nunes, P.; Pedro, J.; Melão, A.; Reis, F.; Carvalho, E.. "Effects of Cyclosporine and Sirolimus on Insulin-Stimulated Glucose Transport and Glucose Tolerance in a Rat Model". Transplantation Proceedings 45 3 (2013): 1142-1148. http://www.ncbi.nlm.nih.gov/pubmed/?term=Effects+of+cyclosporine+and+Sirolimus+on+Insulin-Stimulated+Glucose+Transport+and+Glucose+Tolerance+in+a+Rat+model. Published • 10.1016/j.transproceed.2013.02.009 Parada, Belmiro Ataíde da Costa; Campos, L.; Reis, Flávio; Sereno, J.; Nunes, P.; Mota, A.; Figueiredo, A.; Teixeira, Frederico. "Eficácia da atorvastatina na quimioprevenção da carcinogénese vesical num modelo experimental: Propriedades anti-oxidantes, anti-proliferativas e anti-inflamatórias". Acta Urológica 30 1 (2013): 29-38. http://apurologia.pt/acta/1-2013/efic-atorvast-quim-prev.pdf. Published Sereno, J.; Rodrigues-Santos, P; Vala, H.; Parada, Belmiro Ataíde da Costa; Alves, R.; Teixeira de Lemos, E.; Rocha-Pereira, P.; Teixeira, Frederico; Reis, Flávio. "Different pathways and biomarkers of acute and chronic cyclosporine-induced nephrotoxicity in a rat model–focus on overexpression of mTOR and Mki67 Authors Jo". Port J Nephrol Hypert 27 3 (2013): 197-208. http://www.spnefro.pt/RPNH/PDFs/n3_2013/artigo_09.pdf. Published Mascarenhas-Melo, Filipa; Sereno, José; Teixeira-Lemos, Edite; Marado, Daniela; Palavra, Filipe; Pinto, Rui; Rocha-Pereira, Petronila; Teixeira, Frederico; Reis, Flávio. "Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin". Mediators of Inflammation 2013 612038 (2013): 1-12. Published • 10.1155/2013/612038 Mascarenhas-Melo, Filipa; Palavra, Filipe; Marado, Daniela; Sereno, José; Teixeira-Lemos, Edite; Freitas, Isabel; Isabel-Mendonça, Maria; et al. "Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid". The Scientific World Journal 2013 387849 (2013): 1-16. Published • 10.1155/2013/387849 Mascarenhas-Melo, Filipa; Sereno, José; Teixeira-Lemos, Edite; Ribeiro, Sandra; Rocha-Pereira, Petronila; Cotterill, Ethan; Teixeira, Frederico; Reis, Flávio. "Markers of Increased Cardiovascular Risk in Postmenopausal Women: Focus on Oxidized-LDL and HDL Subpopulations". Disease Markers 35 2 (2013): 85-96. Published • 10.1155/2013/724706 Palavra F; Marado D; Mascarenhas-Melo F; Sereno J; Teixeira-Lemos E; Nunes CC; Gonçalves G; Teixeira F; Reis F. "New markers of early cardiovascular risk in multiple sclerosis patients: oxidized-LDL correlates with clinical staging.". (2013): http://europepmc.org/abstract/med/23478275. 10.1155/2013/567162 Mascarenhas-Melo F; Marado D; Palavra F; Sereno J; Coelho Á; Pinto R; Teixeira-Lemos E; Teixeira F; Reis F. "Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women.". (2013): http://europepmc.org/abstract/med/23570342. 10.1186/1475-2840-12-61 Parada B; Reis F; Cerejo R; Garrido P; Sereno J; Xavier-Cunha M; Neto P; et al. "Omega-3 fatty acids inhibit tumor growth in a rat model of bladder cancer.". (2013): http://europepmc.org/abstract/med/23865049. 10.1155/2013/368178 Fernandes JC; Sereno J; Garrido P; Parada B; Cunha MF; Reis F; Pintado ME; Santos-Silva A. "Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model.". (2012): http://europepmc.org/abstract/med/23342389. 10.3390/md10122661 Fernandes, J.C.; Sereno, J.; Garrido, P.; Parada, B.; Cunha, M.F.X.; Reis, F.; Pintado, M.E.; Santos-Silva, A.. "Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model". Marine Drugs 10 12 (2012): 2661-26. Published Parada, Belmiro; Reis, Flávio; Pinto, Ângela; Sereno, José; Xavier-Cunha, Maria; Neto, Paula; Rocha-Pereira, Petronila; et al. "Chemopreventive Efficacy of Atorvastatin against Nitrosamine-Induced Rat Bladder Cancer: Antioxidant, Anti-Proliferative and Anti-Inflammatory Properties". International Journal of Molecular Sciences 13 12 (2012): 8482-8499. http://www.mdpi.com/1422-0067/13/7/8482. Published • 10.3390/ijms13078482 Sereno, José Vitor Oliveira; Romão, AM; Parada, Belmiro; Lopes, Patricia; Carvalho, Eugénia; Teixeira, Frederico; Reis, Flávio. "Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model". J Pharmacol Pharmacother 3 2 (2012): 143-148. Published Teixeira, Ana Margarida; Rodrigues-Santos, Paulo; Garrido, Patrícia; Costa, Elísio; Parada, Belmiro; Sereno, José Vitor Oliveira; Alves, Rui; et al. "Cardiac antiapoptotic and pro-proliferative effect of recombinant human erythropoietin in a moderate stage of chronic renal failure in the rat". J Pharm Bioallied Sci 4 1 (2012): 76-83. Published Parada B; Reis F; Figueiredo A; Nunes P; Teixeira-Lemos E; Garrido P; Sereno J; et al. "Inhibition of bladder tumour growth by sirolimus in an experimental carcinogenesis model.". (2011): http://europepmc.org/abstract/med/20367636. 10.1111/j.1464-410x.2010.09326.x Teixeira de Lemos, Edite; Pinto, Rui; Oliveira, Jorge; Garrido, Patrícia; Sereno, José; Mascarenhas-Melo, Filipa; Páscoa-Pinheiro, João; Teixeira, Frederico; Reis, Flávio. "Differential Effects of Acute (Extenuating) and Chronic (Training) Exercise on Inflammation and Oxidative Stress Status in an Animal Model of Type 2 Diabetes Mellitus". Mediators of Inflammation 2011 253061 (2011): 1-8. Published • 10.1155/2011/253061 Teixeira, M; Garrido, P.; Rodrigues-Santos, P; Costa, E.; Parada, Belmiro Ataíde da Costa; Sereno, J.; Alves, R.; et al. "Cardio-renal, anti-apoptotic and pro-proliferative effect of recombinant human erythropoietin in a moderate stage of chronic renal failure in the rat". Boletim Sociedade da Portuguesa de Hemorreologia e Microcirculação 26 2 (2011): 5-19. Published • 10.4103/0975-7406.92743 Piloto, N; Teixeira, HM; Garrido, P; Lemos, ET; Teixeira, M; Parada, B; Sereno, J; et al. "Hemorrheological and cardiovascular effect of erythropoietin in a rat model of chronic sports doping". Bol SPHM 25 1 (2010): 11-22. Published Teixeira AM; Garrido, P; Santos P; Costa, E; Parada, B; Alves, R; Almeida, A; et al. "Recombinant human erythropoietin treatment protects the cardio-renal áxis in a model of moderate chronic renal failure". Renal Failure 25 (2010): 9-22. Published Garrido, P.; Reis, Flávio; Costa, E.; Almeida, Anabela; Parada, Belmiro Ataíde da Costa; Teixeira de Lemos, E.; Santos, Paulo; et al. "Effect of Recombinant Human Erythropoietin in a Rat Model of Moderate Chronic Renal Failure – Focus on Inflammation, Oxidative Stress and Function/Renoprotection". The Open Drug Discovery Journal 2 1 (2010): 25-32. http://repositorio.ucp.pt/handle/10400.14/3018. Published Sereno, J.; Romao, AM; Parada, Belmiro Ataíde da Costa; Rodrigues-Santos, P; Garrido, P.; Teixeira-Lemos, E.; Melo, FM; et al. "Efeitos cardio-renais da terapêutica imunossupressora num modelo animal". Bioanálise 7 1 (2010): 47-51. Published Teixeira-Lemos, E.; Mega, Cristina; Vala, H.; Fernandes, Rosa; Parada, Belmiro Ataíde da Costa; Garrido, P.; Sereno, J.; et al. "Novas terapêuticas da diabetes tipo 2: estudos em modelos animais". Bioanálise 7 1 (2010): 36-42. Published Melo, FM; Teixeira-Lemos, E.; Palavra, F; Garrido, P.; Sereno, José; Parada, Belmiro Ataíde da Costa; Baptista, S.; Teixeira, Frederico; Reis, Flávio. "A actividade da paraoxonase 1 como marcador de risco cardiovascular numa população dislipidémica". Bioanálise 7 1 (2010): 36-42. Published Ferreira, Liliana; Teixeira-de-Lemos, Edite; Pinto, Filipa; Parada, Belmiro; Mega, Cristina; Vala, Helena; Pinto, Rui; et al. "Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)". Mediators of Inflammation 2010 1 (2010): 1-11. Published • 10.1155/2010/592760 Teixeira de Lemos, Edite; Reis, Flávio; Espinhaço, L; Baptista, S.; Pinto, Rui; Parada, Belmiro; Garrido, Patrícia; et al. "Low adiponectin levels and paraoxonase activity as markers of oxidative stress and nflammation in atherosclerosis – study in a portuguese population". Proc Eur Assoc Clin Pharmacol Ther V (2010): 211-214. Published Sereno J; Parada B; Reis F; Cunha FX; Teixeira-Lemos E; Garrido P; Pinto R; et al. "Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in a rat model.". (2010): http://europepmc.org/abstract/med/21403827. 10.1155/2010/380937 Teixeira, F.; Sereno, J.; Garrido, P.; Santos-Silva, A.; Pinto, R.; Reis, F.; Carvalho, L.; et al. "Characterization of a Rat Model of Moderate Chronic Renal Failure-Focus on Hematological, Biochemical, and Cardio-Renal Profiles". RENAL FAILURE 31 9 (2009): 833-842. Published • 10.3109/08860220903151435 Piloto, Nuno; Teixeira, Helena M.; Teixeira-Lemos, Edite; Parada, Belmiro; Garrido, Patrícia; Sereno, José; Pinto, Rui; et al. "Erythropoietin Promotes Deleterious Cardiovascular Effects and Mortality Risk in a Rat Model of Chronic Sports Doping". Cardiovascular Toxicology 9 4 (2009): 201-210. Published • 10.1007/s12012-009-9054-2 Parada, Belmiro; Sereno, José Vitor Oliveira; Reis, Flávio; Teixeira-de-Lemos, Edite; Garrido, Patrícia; Pinto, A. F.; Cunha, M. F.; et al. "Anti-inflammatory, anti-proliferative and antioxidant profiles of selective cyclooxygenase-2 inhibition as chemoprevention for rat bladder carcinogenesis". Cancer Biol Ther 8 17 (2009): 1615-1622. http://hdl.handle.net/10400.4/1114. Published Reis, F; Parada, B; Teixeira de Lemos, E; Garrido, P; Dias, A.; Piloto, N; Baptista, S.; et al. "Hypertension Induced by Immunosuppressive Drugs: A Comparative Analysis Between Sirolimus and Cyclosporine". Transplantation Proceedings 41 3 (2009): 868-873. Published • 10.1016/j.transproceed.2009.02.005
Thesis / Dissertation	Sereno, José Vitor Oliveira. "Minimização da nefrotoxicidade induzida pela Ciclosporina A através de protocolos de conversão para Sirolimus – Mecanismos e biomarcadores num modelo animal em rato". PhD, 2015. http://hdl.handle.net/10316/26483.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2019/12/19	MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go?	?” Center for Innovative Biomedicine and Biotechnology (CIIB) Meeting
2019/10/10	“Spectroscopic Biomarkers as a Way of Monitoring MSC Success in Promoting Neuropathological and Phenotypic Ameliorations in Machado-Joseph Disease Models	11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
2019/05/30	Characterization of neurofibromatosis type 1-induced changes in pre-pubertal male and female mice: a combined behavioral, biochemical and neuroimaging study.	SPN meeting 2019
2019/05/30	Neural basis for adult cognitive deficitsin neurofibromatosis type 1 animal model: Relevance for autism spectrum disorders.	SPN meeting 2019
2019/05/22	A miRNA-based gene therapy approach to knock-down mutant ATXN3: alleviation of Machado-Joseph disease phenotype in two mouse models upon two routes of administration	53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
2019/05/22	Repeated transplantation of mesenchymal stromal cells in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy	53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
2019/05/20	Neurofibromatosis 1 results in sex-specific changes in brain morphometry, neurochemical profile and behavior in infant and pre-pubertal mice	Sex Differences, Dimorphisms, Divergences Impact On Brain And Behavior In Health And Disease
2019/04/28	Retinal thinning of inner layers is associated with visual cortex atrophy in a mouse model of Alzheimer’s disease: a longitudinal in vivo multimodal study.	2019 ARVO Annual Meeting
2019/03/26	New chimeric peptides selectively inhibit APPß cleavage decreasing Aß formation and accumulation in AD models	Reunião da AD/PD 2019
2019	Disruption of blood-brain barrier in Machado-Joseph Disease	XLIX Reunião Anual da Sociedade de Farmacologia
2018/11/03	Social skills in autism spectrum disorders relate with connectivity changes in the limbic system: an MRI study in Nf1+/- mice	Neuroscience 2018
2018/11/03	Glutamate/GABA- glutamine cycle imbalance in a mouse model of autism spectrum disorder: relationship to glial reactivity	Neuroscience 2018
2018/09/09	Is the retina a reliable window to look into the brain in alzheimer's disease? lessons from an animal model	XXIII Biennial Meeting of the International Society for Eye Research
2018/07/07	The excitation/inhibition enigma in a mouse model of the autism spectrum disorder: evidence for distinct phenotypes of hippocampus and prefrontal cortex	FENS
2018	New chimeric peptides selectively inhibit APP-ß cleavage	32º Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
2018	Cerebrovascular and blood-brain barrier impairments in Machado-Joseph Disease	XLVIII Reunião Anual da Sociedade de Farmacologia
2018	Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease	XLVIII Reunião Anual da Sociedade de Farmacologia
2018	Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebelar ataxia type-3 AND therapeutic success can be monitored by 1H-MRS	SPDMov 2018 Meeting
2017/05/25	Repeated systemic injection of mesenchymal stem cells sustainably alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease	XV Meeting of the Portuguese Society for Neurosciences
2017/02/02	New peptide inhibitors of bace1: towards alzheimer's disease treatment	XLVII Reunião anual da sociedade portuguesa de farmacologia, XXXV Reunião de farmacologia clínica, XVI Reunião de toxicologia
2017/02/02	Sustainable alleviation of motor impairments and neuropathology upon repeated intravenous transplantation of mesenchymal stromal cells in machado-joseph disease mice.	XLVII Reunião anual da sociedade portuguesa de farmacologia, XXXV Reunião de farmacologia clínica, XVI Reunião de toxicologia
2017	Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons	10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
2017	Repeated intravenous transplantation of mesenchymal stromal cells sustainable alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease	Brain Without Borders Meeting
2017	Magnetic Resonance and PET imaging of a transgenic mouse model of Alzheimer's disease: an in vivo longitudinal study	SPN Meeting
2016/12/08	Redox changes and bioenergetic defects in striatum and cortex of pre-symptomatic and symptomatic Huntington disease mice	Neurocience 2016
2016/12/08	New BACE1 inhibitors decrease Aß production and accumulation in the 3xtg-AD mouse model	XIX National Congress of Biochemistry
2016/05/26	Glycation impairs adipose tissue capillarization, blood flow and expandability causing insulin resistance	3rd World Congress of Glycation and Maillard Reaction
2016/05/26	Glycation impairs hepatic lipid metabolism and glucose tolerance in high-fat diet-induced obese rats, contributing to the onset of NAFLD	3rd World Congress of Glycation and Maillard Reaction
2016	Redox and mitochondrial functional switches in striatum and cortex of pre-symptomatic and symptomatic Huntington’s disease mouse model	XIX National Congress of Biochemistry
2015/12/03	Evaluation of Brain Structures Volumes on Transgenic Mice Model of Machado Joseph Disease	7th Annual Meeting of IBILI
2015/12/03	Methylglyoxal impairs liver lipidomic profile during high-fat diet feeding: comparison between LC-MS and MRI data	7th Annual Meeting of IBILI
2015/12/03	Aging fat: glycation impairs adipose tissue blood flow and expandability causing insulin resistance	7th Annual Meeting of IBILI
2015/12/03	Regional difference in susceptibility to modulation excitation/inhibition balance and glial function in mouse model of neurofibromatosis type 1	7th Annual Meeting of IBILI
2015/09/14	Glycation and high-fat diet trigger distinct functional consequences in the heart: an MRI study	51st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD)
2015/09/14	Methylglyoxal impairs high-fat diet-induced adipose tissue expansion causing systemic dysmetabolism	51st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD)
2014/12/17	Inhibition of kidney expression of mTOR, NF-¿ß1 and CTGF as key players in renoprotection afforded by conversion from cyclosporine to sirolimus in a rat model	XVIII Congress of the Portuguese Biochemical Society
2014/12/11	Adipose tissue irrigation after diet-induced expansion and glycation-induced microvascular dysfunction	VI Annual Meeting of IBILI
2014/12/11	Hepatic Lipid Profile in rats with diet-induced glycation and obesity	6th Annual Meeting of IBILI
2014/12/11	Glycation and high-fat diet trigger distinct functional consequences in the heart: an MRI study	6th Annual Meeting of IBILI
2014/05/31	Transcriptor Factors Responsible for Epo Gene Regulation, Triggered by Administration of rHuEPO High Doses.	51st ERA-EDTA Congress
2014/05/31	Regulation of Liver and Kidney Erythropoietin Gene Expression in a Rat Model of Anemia Associated with Chronic Renal Failure	51st ERA-EDTA Congress
2014/05/31	Biomarkers of transition from cyclosporine-induced renal dysfunction to nephrotoxicity	51st ERA-EDTA Congress
2014	Kidney mTOR and Mki67 overexpression as biomarkers of transition from cyclosporine-induced renal dysfunction to nephrotoxicity	XLIV Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXII Reunião de Farmacologia Clínica e XIII Reunião de Toxicologia (Coimbra)
2013	Markers of increased cardiovascular risk in men and postmenopausal woman in healthy and diabetic populations	Reunião da Sociedade Portuguesa de Farmacologia (Porto)
2013	Different pathways and markers of short- and long-term Cyclosporine-induced nephrotoxicity in a rat model.	Congresso da APEDT (Vilamoura)
2013	Papel dos agentes imunossupressores no metabolismo da glucose e dos lípidos in vivo
2013	Minimization of cyclosporin-induced nephrotoxicity with sirolimus in the rat – reduction and conversion protocols.	XLIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXI Reunião de Farmacologia Clínica e XII Reunião de Toxicologia (Porto)
2012	Protecção da nefropatia diabética pela sitagliptina: estudos num modelo animal de diabetes tipo 2	XIII Congresso Português de Endocrinologia (Coimbra)
2012	HDL quality and paraoxonase 1 activity as better markers of dyslipidaemia and cardiovascular risk in type 2 diabetes patients?	Reunião da Sociedade Portuguesa de Farmacologia (Lisboa)
2012	Risco cardiovascular global no doente hipertenso e hipertenso diabético – caracterização fenotípica e genotípica de novos possíveis marcadores lipídicos, metabólicos, inflamatórios e angiogénicos	6º Congresso Português de Hipertensão (Vilamoura)
2012	Markers of earlier cardiovascular risk in multiple sclerosis patients and putative correlation with clinical staging	Reunião da Sociedade Portuguesa de Farmacologia (Lisboa)
2012	Avaliação de factores de risco cardiovascular em amostras populacionais do litoral e do interior de Portugal: estudo prospectivo preliminar	6º Congresso Português de Hipertensão (Vilamoura)
2012	Paraoxonase 1 activity correlates with HDL quality and might be viewed as new markers of cardiometabolic risk in type 2 diabetes patients	10º Congresso Português de Diabetes (Vilamoura)
2012	Efeitos da inibição da dpp-4 na nefropatia diabética: estudos num modelo animal de diabetes tipo 2	10º Congresso Português de Diabetes (Vilamoura)
2012	New markers of cardiometabolic risk in dyslipidaemic type 2 diabetes patients – focus on paraoxonase 1 status and HDL-subpopulations	XIII Congresso Português de Endocrinologia (Coimbra)
2012	A qualidade das HDL e não tanto a sua quantidade como marcador de risco cardiovascular no acidente vascular cerebral – Realce para a actividade da paraoxonase 1	Reunião conjunta da Sociedade Portuguesa de Hemorreologia e Microcirculação (SPHM) e o Núcleo de Biologia Vascular da Sociedade Portuguesa de Angiologia e Cirurgia Vascular (SPACV) (Lisboa)
2012	Erythropoietic response to rhEPO therapy is dependent on the stage of renal failure - an experimental study in nephrectomized rats	XXVI Congresso Português de Nefrologia Sociedade Portuguesa de Nefrologia (Algarve, Portugal)
2012	Sirolimus ameliorates cyclosporin-induced nephropathy in a rat model	XLII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXX Reunião de Farmacologia Clínica, XI Reunião de Toxicologia Sociedade Portuguesa de Farmacologia (Lisboa)
2012	Chitooligosaccharides - bioactive properties with pharmacological potential	XLII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXX Reunião de Farmacologia Clínica, XI Reunião de Toxicologia Sociedade Portuguesa de Farmacologia (Lisboa)
2012	Serum, urinary and renal tissue markers of early nephropathy in rats under immunosuppressive therapy: cyclosporine vs Sirolimus.	XI Congresso Luso-Brasileiro de Transplantação (Coimbra)
2012	Cyclosporine-induced nephropathy is ameliorated when converted to sirolimus – evidences from an experimental rat mode.	XI Congresso Luso-Brasileiro de Transplantação (Coimbra)
2012	Renal impact of cyclosporine and sirolimus-based immunotherapy in an animal model – avoidance vs reduction vs conversion.	XI Congresso Luso-Brasileiro de Transplantação (Coimbra)
2012	Cyclosporine A and sirolimus treatments impair glucose and lipid metabolism in vivo.	XI Congresso Luso-Brasileiro de Transplantação (Coimbra)
2012	Conversion from cyclosporine a to sirolimus impairs glucose and lipid metabolism in wistar rats.	XI Congresso Luso-Brasileiro de Transplantação (Coimbra)
2012	Conversion from cyclosporine to sirolimus ameliorates nephropathy in an animal model.	Conferência CEF 2012 (Coimbra)
2012	Sirolimus ameliorates cyclosporin-induced nephrotoxicity in a rat model – focus on renal lesions, oxidative stress, inflammation, proliferation and Angiogenesis.	European Congress of Pathology (Prague)
2012	Effects of Sirolimus and Cyclosporine at the cardiovascular level.	VII Annual CICS Symposium 2012 (Covilhã)
2012	Erythropoietic response to rhEPO therapy is dependent on the stage of renal failure – an experimental study in nephrectomized rats.	I3S Scientific Retreat 2012 (Póvoa do Varzim)
2012	Cyclosporin-induced nephrotoxicity is attenuated with replacement for sirolimus – focus on oxidative stress, inflammation, proliferation and angiogenesis	Reunião conjunta da Sociedade Portuguesa de Hemorreologia e Microcirculação e Núcleo de Biologia Vascular da Sociedade Portuguesa de Angiologia e Cirurgia Vascular (Lisboa)
2012	Mecanismos subjacentes ao efeito anti-hipertensivo e renoprotetor da conversão de ciclosporina para sirolimus num modelo animal.	6º Congresso Português de Hipertensão e Risco Cardiovascular Global (Vilamoura)
2012	A qualidade das HDL como marcador de risco cardiovascular no acidente vascular cerebral – correlação com a actividade da paraoxonase 1.	6º Congresso Português do AVC (Porto)
2012	Protecção da nefropatia diabética pela sitagliptina: estudos num modelo animal de diabetes tipo 2.	XIII Congresso Português de Endocrinologia (Coimbra)
2011	Cardiorenal benefits of replacement of Cyclosporin with Sirolimus in the rat: early versus late conversion.	XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica e X Reunião de Toxicologia (Coimbra)
2011	Efeitos cardio-renais do uso precoce de rhepo num modelo animal de insuficiência renal crónica	V Seminário de Investigação em Enfermagem; I Seminário Internacional de Investigação em Saúde (Porto)
2011	Patologias do Colesterol e Novos Marcadores de Diagnóstico Laboratorial: Hipercolesterolemia: A Actividade da Paraoxonase 1 e as Subclasses de HDL como Melhores Marcadores De Risco Cardiovascular Numa População De Diabéticos Tipo 2	15ª Jornadas Científicas de Análises Clínicas, do Conselho do Colégio de Especialidade de Análises Clínicas (Guimarães)
2011	Benefícios cardio-renais da conversão precoce versus tardia de ciclosporina para sirolimus num modelo animal	V Seminário de Investigação em Enfermagem; I Seminário Internacional de Investigação em Saúde (Porto)
2011	Influence of Genetic and Non-Genetic Factor in PON 1 Activity in Hemodialysis Patients	XIX Congresso Nacional de Aterosclerose (Évora)
2011	Replacement of Cycosporin for Sirolimus have less cardiorenal side-effects and glucose metabolism impairment in a rat model	XIX Congresso Nacional de Aterosclerose (Évora)
2011	A actividade da paraoxonase 1 como novo marcador de risco cardiometabólico em doentes hipertensos não controlados – estudo em diabéticos tipo	5º Congresso Português de Hipertensão Sociedade Portuguesa de Hipertensão (Vilamoura)
2011	Efeitos Antiateroscleróticos Renoprotectores com Doses Baixas de Sitagliptina num Modelo Animal de Diabetes Tipo 2.	XIX Congresso Nacional de Aterosclerose (Évora)
2011	HDL-c quality and subpopulations as putative better markers of dyslipidaemia and cardiometabolic risk in type 2 diabetes patients than the traditional total HDL-c content.	XIX Congresso Nacional de Aterosclerose (Évora)
2011	Immunosuppressive agents play an important role in glucose metabolism of Adipose Tissue.	Keystone Symposia on molecular and cellular Biology (Ireland)
2011	Metabolic side-effects of immunossupressive agents in the rat: cyclosporine and sirolimus.	GIFT Meeting (Annual SPD Meeting) (Tomar)
2011	Effect of a dipeptidyl peptidase-4 inhibitor, sitagliptin,	5º Congresso Português de Hipertensão (Vilamoura)
2011	A actividade da paraoxonase 1 como novo marcador de risco cardiometabólico em doentes hipertensos não controlados – estudo em diabéticos tipo 2	5º Congresso Português de Hipertensão (Vilamoura)
2011	Reno and cardioprotective action of erythropoietin in an animal model of moderate chronic renal failure	XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica e X Reunião de Toxicologia (Coimbra)
2010	The influence of physical exercise on PON-1 activity in a population with high cardiovascular risk	14º Congresso Português de Obesidade (Porto)
2010	Efeito da utilização crónica de sitagliptina em baixa dose no risco cardiometabólico – estudo em modelo animal de diabetes mellitus tipo 2	18º Congresso Nacional de Aterosclerose Sociedade Portuguesa de Aterosclerose (Vilamoura)
2010	Efeitos cardiometabólicos da sitagliptina num modelo de Diabetes Mellitus Tipo 2: destaque para o stress oxidativo, a inflamação e a protecção do tecido pancreático	9º Congresso Português de Diabetes Sociedade Portuguesa da Diabetes (Vilamoura)
2010	DPP-4 inhibition with low dose sitagliptin improves diabetic dysmetabolism, inflammation and pancreatic lesions in a rodent model of T2DM	XVII Congresso Nacional De Bioquímica Sociedade Portuguesa de Bioquímica (Porto)
2010	Novas terapêuticas da diabetes tipo 2: estudos em modelos animais	VIII Congresso de Análise Clínicas e Saúde Pública (Coimbra)
2010	Carcinoma da bexiga: prevenção farmacológica num modelo de experimentação animal	VIII Congresso de Análise Clínicas e Saúde Pública (2010)
2010	Utilização de parâmetros quantitativos e semi-quantitativos para avaliação dos Ilhéus de Langerhans num modelo animal de Diabetes Mellitus tipo 2	Março (Viseu)
2010	Immunosuppressive agents alter glucose metabolism, blood pressure and heart rate in rats.	2nd National Meeting on Medicinal Chemistry /2enqt (Coimbra)
2010	A actividade da paraoxonase 1 como marcador de risco cardiovascular numa população dislipidémica	VIII Congresso de Análise Clínicas e Saúde Pública (Coimbra)
2009	Pathophysiological mechanisms underlying the cardiovascular side-effects of sirolimus versus cyclosporine	14th Congress of the European Society for Organ Transplantation European Society for Organ Transplantation (Paris, France)
2009	Pleiotropic effect of atorvastatin in bladder cancer prevention - implications to an eventual recommendation for an earlier use to promote dual prevention in dyslipidaemic patients of higher risk	17º Congresso Português de Aterosclerose Sociedade Portuguesa de Aterosclerose (Cascais)
2009	Inhibition of bladder tumor growth by cyclooxygenases inhibitors in a rat model	XL Reunião Anual da Sociedade Portuguesa de Farmacologia,XXVIII Reunião de Farmacologia Clínica e IX Reunião de Toxicologia Sociedade Portuguesa de Farmacologia (Porto)
2009	Antitumoral properties of a cyclooxigenase-2 inhibitor and immunosupression agents on rat urinary bladder carcinogenesis.	30th Congress of Société Internationale d’Urologie Société Internationale d’Urologie (Shangai)
2009	Inhibition of bladder tumor growth by immunosuppression agents: experimental study	14th Congress of the European Society for Organ Transplantation (Paris)
2009	Recombinant human erythropoietin therapy has beneficial cardio-renal effects on moderate stages of chronic renal failure in the rat	9th Congresso da EACPT (European Association for Clinical Pharmacology and Therapeutics) (Edimburgo)
2009	Inhibition of bladder tumor growth by a cyclooxygenase-2 inhibitor and immunosuppression agents in an experimental study	9th Congresso da EACPT (European Association for Clinical Pharmacology and Therapeutics) (Edimburgo)
2009	Adiponectin circulating levels as an emerging biomarker of cardiovascular risk in the portuguese population - a preliminary study	18th IFCC – EFCC European Congress of Clinical Chemistry and Laboratory Medicine National Congress of the Austrian Society of Laboratory Medicine and Clinical Chemistry (Innsbruck)
2008	Cardiovascular effects of rh erythropoietin treatment in an experimental model of sports doping	XXXIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVI Reunião de Farmacologia Clínica e VIII Reunião de Toxicologia Sociedade Portuguesa de Farmacologia (Lisboa)
2008	Effect of recombinant human erythropoietin therapy on the cardio-renal anaemia syndrome in an animal model of moderate renal failure	16º Congresso Português de Aterosclerose e 10º Congresso da SILAT Sociedade Portuguesa da Aterosclerose (Vilamoura)
2008	Inhibition of bladder tumor growth by a ciclooxigenase-2 inhibitor and immunossupression agents: Experimental study	XXXIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVI Reunião de Farmacologia Clínica e VIII Reunião de Toxicologia Sociedade Portuguesa de Farmacologia (Lisboa)
2008	Hypertension induced by immunosuppressive drugs – comparative analysis between sirolimus and cyclosporine.	VII Congresso Luso Brasileiro de Transplantação (Algarve)
2008	Mechanisms of drug induced hypertension in the rat – comparative analysis between sirolimus and cyclosporine.	Anual Meeting American Urology Association (Orlando)
2007	Comparative analysis between Sirolimus and Ciclosporine effects in the rat – focus on cardiovascular evaluation	XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica e VII Reunião de Toxicolog Sociedade Portuguesa de Farmacologia (Coimbra)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2020/01/02 - 2020/01/29	Lab rotation - The student learn experimental surgery and animal take care concerning to resonance magnetic imaging. The study complains different imaging modalities, such as, T1-W contrast, T2-W, ASL, proton MRS (PRESS) and functional MRI, in a double vessel occlusion rat model. Supervisor	Mestrado em biologia Celular e molecular (Master) Universidade de Coimbra Departamento de Ciências da Terra, Portugal
2018/10/01 - 2019/09/30	Optimization of the sensitivity of a preclinical RPC-PET tomography and its image fusion with an animal magnetic resonance system Co-supervisor	Mestrado Integrado em Engenharia Física (Master) Universidade de Coimbra Centro de Física, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2007 - 2007	V Jornadas Nacionais de Bioquímica e X Jornadas Nacionais de Química Industrial Meeting (Co-organisor)
2006 - 2006	IV Jornadas Nacionais de Bioquímica e IX Jornadas Nacionais de Química Industrial Symposium (Co-organisor)
2005 - 2005	III Jornadas Nacionais de Bioquímica Meeting (Other)
2005 - 2005	VIII Jornadas Nacionais de Química Industrial Meeting (Other)

Event participation

	Activity description Type of event	Event name Institution / Organization
2016/12/19 - 2016/12/20	1st meeting on biomedical research Conference	1st meeting on biomedical research CNC.IBILI, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2019/11/04 - 2019/11/15	III Modular Training in Laboratory Animal Science	III Modular Training in Laboratory Animal Science (Outros)	Universidade de Coimbra, Portugal
2019/11/13 - 2019/11/13	Portuguese Nuclear Magnetic Resonance Network - the Portuguese NMR network was created with the support of the Portuguese Foundation for Science and Technology (FCT). Course: NMR in Drug Discovery - From Protein-Ligand Interactions to Molecular Imaging class title: Imaging in basic translational research - The potential of animal magnetic resonance imaging	NMR in Drug Discovery - From Protein-Ligand Interactions to Molecular Imaging (Curso de doutoramento (conclusão de unidades curriculares))	Fundação para a Ciência e a Tecnologia, Portugal
2019/09/27 - 2019/09/27	Doctoral Programme in Health Sciences class title: functional imaging: in vivo molecula imaging	Doctoral Programme in Health Sciences (Curso de doutoramento (conclusão de unidades curriculares))	Universidade de Coimbra Faculdade de Medicina, Portugal
2019/05/25 - 2019/05/25	advanced course in animal models of human diseases. Class title: animal models in molecular imaging	Doctoral Programme in Health Sciences (Curso de doutoramento (conclusão de unidades curriculares))	Universidade de Coimbra Faculdade de Medicina, Portugal
2019/01/07 - 2019/01/18	II Modular Training in Laboratory Animal Science	II Modular Training in Laboratory Animal Science (Outros)	Universidade de Coimbra, Portugal
2018/11/20 - 2018/11/20	course: RMN biomedical and molecular imaging; 3 master's degrees: biomedical engineer, biochemistry and cellular biology	RMN biomedical and molecular imaging (Mestrado)	Universidade de Coimbra, Portugal
2018/11/13 - 2018/11/13	course: RMN biomedical and molecular imaging 3 master's degrees: biomedical engineer, biochemistry and cellular biology	RMN biomedical and molecular imaging (Mestrado)	Universidade de Coimbra, Portugal
2017/09/25 - 2017/10/06	II Modular Training in Laboratory Animal Science	I Modular Training in Laboratory Animal Science (Outros)

Distinctions

Other distinction

2014	Prémio Mantero Belard Prémio Santa Casa Neurociências, Portugal
2012	Trabalho premiado como o melhor resumo. Sociedade Portuguesa de Nefrologia, Portugal
2012	Trabalho premiado como a melhor comunicação em Investigação Básica. Sociedade Portuguesa de Hemorreologia e Microcirculação (SPHM) e o Núcleo de Biologia Vascular, Portugal
2012	Trabalho premiado como melhor comunicação oral na área “Health Surveillance”. Centro de Estudos Farmacêuticos da Faculdade de Farmácia da Universidade de Coimbra, Portugal
2011	Menção Honrosa em investigação clínica Sociedade Portuguesa de Diabetes, Endocrinologia e Metabolismo, Portugal
2011	1º PRÉMIO para melhor comunicação oral de trabalho científico Sociedade Portuguesa de Hipertensão, Portugal
2011	Atribuição de uma bolsa monetária no valor de 2500€ Sociedade Portuguesa de Diabetologia, Portugal
2011	Prémio Roche para Melhor Artigo Original não publicado na Área da Nefrologia Básica Roche, Portugal
2011	Melhor Comunicação Livre Sociedade Portuguesa de Aterosclerose, Portugal
2009	1º PRÉMIO para comunicações orais Sociedade Portuguesa de Aterosclerose, Portugal
2008	1º PRÉMIO para comunicações orais Sociedade Portuguesa de Aterosclerose, Portugal