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Pedro Ricardo da Rocha Florindo. Concluiu o(a) Doutoramento em Química em 2008 pelo(a) Universidade de Lisboa. Publicou 23 artigos em revistas especializadas. Possui 1 capítulo(s) de livros.
Identification

Personal identification

Full name
Pedro Ricardo da Rocha Florindo

Citation names

  • Florindo, Pedro
  • Florindo, Pedro R.

Author identifiers

Ciência ID
7415-39D0-8294
ORCID iD
0000-0002-8582-7036
Researcher Id
J-2908-2013
Scopus Author Id
24481090300

Email addresses

  • pedrorrflorindo@ff.ulisboa.pt (Professional)

Addresses

  • Instituto de Investigação do Medicamento, Universidade de Lisboa. Av. Prof. Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Inorganic Chemistry
  • Exact Sciences - Chemical Sciences - Inorganic Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Chemical Sciences - Inorganic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Catalan Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2008
Concluded
 Química (Doutoramento)
Major in Química Inorgânica
Universidade de Lisboa, Portugal
"Síntese de Compostos Organometálicos com Potencial Aplicação em Óptica Não Linear" (THESIS/DISSERTATION)
 Aprovado com Distinção e Louvor
2003
Concluded
 Chemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Não aplicável" (THESIS/DISSERTATION)
 16/20
Affiliation

Science

Category
Host institution 		Employer
2019/03/01 - Current Contracted Researcher (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2017/01/02 - 2019/02/28 Postdoc (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2012/06/01 - 2016/06/30 Postdoc (Research) Universidade de Lisboa Centro de Química Estrutural, Portugal
2008/10/06 - 2011/09/30 Contracted Researcher (Research) Universitat de Barcelona Facultat de Farmacia, Spain

Teaching in Higher Education

Category
Host institution 		Employer
2020/12/01 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Contract

Designation Funders
2018/10/01 - 2021/09/30 Tricks or Treats? Toward Selective Organoruthenium(II) Glycoconjugated Anticancer Agents
PTDC/MED-QUI/31468/2017
Principal investigator
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2010/03/01 - 2013/02/28 Enantioselective Synthesis of Indole Alcaloids and their Application as NMDA Antagonists
PTDC/QUI-QUI/111664/2009
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2013/01/01 Centre de Recerca i Desenvolupament en Síntesi Orgànica per a la Indústria Químicofarmacèutica (SINTEFARMA)
2009SGR1111
Researcher
Universitat de Barcelona Facultat de Farmacia, Spain
 Generalitat de Catalunya Agència de Gestió d'Ajuts Universitaris i de Recerca
Concluded
2006/09/01 - 2009/08/31 Synthesis of Organometallic Molecular and Polymeric Materials with NLO Properties
PTDC/QUI/66148/2006
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Garcia, M.H.; Florindo, P.. "Second order nonlinear optical properties of group 8 half-sandwich organometallic complexes". 347-372. 2011.
Journal article
  1. Florindo, Pedro R.. "Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype". Inorganic Chemistry (2020): http://dx.doi.org/10.1021/acs.inorgchem.0c01795.
    10.1021/acs.inorgchem.0c01795
  2. Florindo, Pedro R.. "Metabolism of N-ethylhexedrone and buphedrone: an in vivo study in mice using HPLC-MS/MS". Journal of Chromatography B (2020): http://dx.doi.org/10.1016/j.jchromb.2020.122340.
    10.1016/j.jchromb.2020.122340
  3. Florindo, Pedro R.. "Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment". Neurotoxicity Research (2020): http://dx.doi.org/10.1007/s12640-020-00229-6.
    10.1007/s12640-020-00229-6
  4. Pedro R. Florindo; Diane M. Pereira; Pedro M. Borralho; M. F. M. Piedade; M. Conceição Oliveira; Ana M. Dias; Cecília M. P. Rodrigues; Ana C. Fernandes. "Organoruthenium(ii) nucleoside conjugates as colon cytotoxic agents". New Journal of Chemistry 43 3 (2019): 1195-1201. https://doi.org/10.1039/C8NJ04515A.
    10.1039/C8NJ04515A
  5. Ferreira, C.; Vaz, A.R.; Florindo, P.R.; Lopes, Á.; Brites, D.; Quintas, A.. "Development of a high throughput methodology to screen cathinones’ toxicological impact". Forensic Science International 298 (2019): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062700246&partnerID=MN8TOARS.
    10.1016/j.forsciint.2019.02.022
  6. Cabrita, I.R.; Florindo, P.R.; Costa, P.J.; Oliveira, M.C.; Fernandes, A.C.. "Hydrophosphonylation of aldehydes catalyzed by cyclopentadienyl ruthenium(II) complexes". Molecular Catalysis 450 (2018): 77-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043976863&partnerID=MN8TOARS.
    10.1016/j.mcat.2018.03.001
  7. Cabrita, I.R.; Sousa, S.C.A.; Florindo, P.R.; Fernandes, A.C.. "Direct Aminophosphonylation of aldehydes catalyzed by cyclopentadienyl ruthenium(II) complexes". Tetrahedron (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042927767&partnerID=MN8TOARS.
    10.1016/j.tet.2018.02.047
  8. Cabrita, I.R.; Florindo, P.R.; Fernandes, A.C.. "Cyclopentadienyl-ruthenium(II) complexes as efficient catalysts for the reduction of carbonyl compounds". Tetrahedron 73 11 (2017): 1511-1516. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011556626&partnerID=MN8TOARS.
    10.1016/j.tet.2017.01.067
  9. Florindo, P.R.; Costa, P.J.; Piedade, M.F.M.; Robalo, M.P.. "PH-Switchability and Second-Order Nonlinear Optical Properties of Monocyclopentadienylruthenium(II)/iron(II) Tetrazoles/Tetrazolates: Synthesis, Characterization, and Time-Dependent Density Functional Theory Calculations". Inorganic Chemistry 56 12 (2017): 6849-6863. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020915742&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.7b00138
  10. Florindo, P.R.; Pereira, D.M.; Borralho, P.M.; Costa, P.J.; Piedade, M.F.M.; Rodrigues, C.M.P.; Fernandes, A.C.. "New [(¿5-C5H5)Ru(N-N)(PPh3)][PF6] compounds: Colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes". Dalton Transactions 45 30 (2016): 11926-11930. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979891831&partnerID=MN8TOARS.
    10.1039/c6dt01571a
  11. Bernando, J.R.; Florindo, P.R.; Wolff, M.; Machura, B.; Fernandes, A.C.. "Reduction of aldehydes catalyzed by oxo-rhenium(V) complexes containing heterocyclic ligands". Tetrahedron Letters 56 2 (2015): 414-418. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949114900&partnerID=MN8TOARS.
    10.1016/j.tetlet.2014.11.119
  12. Florindo, P.R.; Pereira, D.M.; Borralho, P.M.; Rodrigues, C.M.P.; Piedade, M.F.M.; Fernandes, A.C.. "Cyclopentadienyl-ruthenium(II) and iron(II) organometallic compounds with carbohydrate derivative ligands as good colorectal anticancer agents". Journal of Medicinal Chemistry 58 10 (2015): 4339-4347. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930640155&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.5b00403
  13. Florindo, P.; Marques, I.J.; Nunes, C.D.; Fernandes, A.C.. "Synthesis, characterization and cytotoxicity of cyclopentadienyl ruthenium(II) complexes containing carbohydrate-derived ligands Dedicated to Prof. Maria José Calhorda on the occasion of her 65th birthday.". Journal of Organometallic Chemistry 760 (2014): 240-247. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899446667&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2013.09.004
  14. Sousa, S.C.A.; Bernardo, J.R.; Florindo, P.R.; Fernandes, A.C.. "Efficient and selective oxidation of alcohols catalyzed by oxo-rhenium complexes". Catalysis Communications 40 (2013): 134-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880076221&partnerID=MN8TOARS.
    10.1016/j.catcom.2013.06.012
  15. Bernardo, J.R.; Sousa, S.C.A.; Florindo, P.R.; Wolff, M.; Machura, B.; Fernandes, A.C.. "Efficient and chemoselective direct reductive amination of aromatic aldehydes catalyzed by oxo-rhenium complexes containing heterocyclic ligands". Tetrahedron 69 43 (2013): 9145-9154. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883793197&partnerID=MN8TOARS.
    10.1016/j.tet.2013.08.016
  16. Amat, M.; Ramos, C.; Pérez, M.; Molins, E.; Florindo, P.; Santos, M.M.M.; Bosch, J.. "Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline". Chemical Communications 49 19 (2013): 1954-1956. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873666887&partnerID=MN8TOARS.
    10.1039/c2cc38540f
  17. Madeira, P.J.A.; Morais, T.S.; Silva, T.J.L.; Florindo, P.; Garcia, M.H.. "Gas-phase behaviour of Ru(II) cyclopentadienyl-derived complexes with N-coordinated ligands by electrospray ionization mass spectrometry: Fragmentation pathways and energetics". Rapid Communications in Mass Spectrometry 26 15 (2012): 1675-1686. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862733700&partnerID=MN8TOARS.
    10.1002/rcm.6276
  18. Pérez, M.; Arioli, F.; Rigacci, G.; Santos, M.M.M.; Gõmez-Esqué, A.; Escolano, C.; Florindo, P.; et al. "Stereocontrolled generation of benzo[a]- and indolo[2,3-a]quinolizidines from (S)-tryptophanol and (S)-(3,4-dimethoxyphenyl)alaninol-derived lactams". European Journal of Organic Chemistry 20-21 (2011): 3858-3863. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960295012&partnerID=MN8TOARS.
    10.1002/ejoc.201100294
  19. Amat, M.; Fabregat, R.; Griera, R.; Florindo, P.; Molins, E.; Bosch, J.. "Biomimetic construction of the hydroquinoline ring system. Diastereodivergent enantioselective synthesis of 2,5-disubstituted cis -decahydroquinolines". Journal of Organic Chemistry 75 11 (2010): 3797-3805. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953002542&partnerID=MN8TOARS.
    10.1021/jo1005894
  20. Moreno, V.; Lorenzo, J.; Aviles, F.X.; Garcia, M.H.; Ribeiro, J.P.; Morais, T.S.; Florindo, P.; Robalo, M.P.. "Studies of the antiproliferative activity of ruthenium (II) Cyclopentadienyl-derived complexes with nitrogen coordinated ligands". Bioinorganic Chemistry and Applications 2010 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77954567506&partnerID=MN8TOARS.
    10.1155/2010/936834
  21. Garcia, M.H.; Valente, A.; Florindo, P.; Morais, T.S.; Piedade, M.F.M.; Duarte, M.T.; Moreno, V.; Avilés, F.X.; Loreno, J.. "New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy". Inorganica Chimica Acta 363 14 (2010): 3765-3775. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957982339&partnerID=MN8TOARS.
    10.1016/j.ica.2010.05.034
  22. Garcia, M.H.; Florindo, P.; Piedade, M.F.M.; Duarte, M.T.. "Synthesis and structural characterization of silver(I) complexes with moon-shaped benzo[1,2-b;4,3-b']dithiophene phosphine derivative ligands". Polyhedron 28 2 (2009): 239-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149328390&partnerID=MN8TOARS.
    10.1016/j.poly.2008.11.013
  23. Helena Garcia, M.; Morais, T.S.; Florindo, P.; Piedade, M.F.M.; Moreno, V.; Ciudad, C.; Noe, V.. "Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands". Journal of Inorganic Biochemistry 103 3 (2009): 354-361. http://www.scopus.com/inward/record.url?eid=2-s2.0-59649090635&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2008.11.016
  24. Garcia, M.H.; Florindo, P.; Piedade, M.F.M.; Duarte, M.T.; Robalo, M.P.; Goovaerts, E.; Wenseleers, W.. "Synthesis and structural characterization of ruthenium(II) and iron(II) complexes containing 1,2-di-(2-thienyl)-ethene derived ligands as chromophores". Journal of Organometallic Chemistry 694 3 (2009): 433-445. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149481277&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2008.11.019
  25. Garcia, M.H.; Florindo, P.; Piedade, M.d.F.M.; Maiorana, S.; Licandro, E.. "New organometallic Ru(II) and Fe(II) complexes with tetrathia-[7]-helicene derivative ligands". Polyhedron 28 3 (2009): 621-629. http://www.scopus.com/inward/record.url?eid=2-s2.0-59349104787&partnerID=MN8TOARS.
    10.1016/j.poly.2008.12.036
  26. Garcia, M.H.; Florindo, P.; Piedade, M.F.M.; Duarte, M.T.; Robalo, M.P.; Heck, J.; Wittenburg, C.; Holtmann, J.; Licandro, E.. "Synthesis of organometallic Ru(II) and Fe(II) complexes containing fused rings hemi-helical ligands as chromophores. Evaluation of non-linear optical properties by HRS". Journal of Organometallic Chemistry 693 18 (2008): 2987-2999. http://www.scopus.com/inward/record.url?eid=2-s2.0-48949086328&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2008.05.035

Other

Other output
  1. Half- Sandwich cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype. 2020. Florindo, Pedro R.. http://dx.doi.org/10.26434/chemrxiv.12155178.v1.
    10.26434/chemrxiv.12155178.v1
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/11/16 Abuse drugs, COPD chemical probes and organometallic anticancer agents: current approaches @iMed MedChem group IMed Post-Doc Seminar Series
Research Institute for Medicines (Lisbon, Portugal)
2018/04/12 Breaking Bad: Síntese, Purificação e Caracterização de NSP e Metabolitos New Psychoactive Substances Euronet Workshop
Universidade de Lisboa, Faculdade de Farmácia (Lisbon, Portugal)
2015/05/07 Searching for Synergies: Group 8 Organometallic Compounds bearing Bio-derivative Ligands CQE@Ciencias Conferences
Universidade de Lisboa, Faculdade de Ciências (Lisbon, Portugal)
2013/09/05 Synthesis, Characterization and Citotoxic Activity of Cyclopentadienyl Ruthenium(II) Complexes with Carbohydrate Derived Ligands 10º Encontro Nacional de Química Orgânica
Sociedade Portuguesa de Química (Lisbon, Portugal)
2010/07/08 Crystallization techniques to obtain crystals suitable for Single Crystal X-ray Diffraction characterization Bioactive Nitrogen-containing Compounds Group seminars
(Barcelona, Spain)
2005/02/04 New organometallic Ru(II) and Fe(II) complexes with tetrathia-[7]-helicene derivative ligands COST D14 Meeting
(Lisbon, Portugal)
2004/03/11 Synthesis of organometallic Ru(II) and Fe(II) complexes containing fused rings hemi-helical ligands as chromophores COST D14 Meeting
(Leuven, Belgium)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/10/01 - Current Ruthenium(II) polypyridyl complexes as a structural platform for multivalent PROTACs
Supervisor
 Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/12/01 - Current Emerging targeted therapies to metabolic liver disease
Co-supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/04/01 - Current Tackling solvation and permeability using computational methods: the role of noncovalent interactions
Co-supervisor
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/10/01 - Current Development of metal-linked Proteolysis Targeting Chimeras
Supervisor
 Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/04/20 - 2021/10/15 Ruthenium(II) polypyridyl complexes as a structural platform for multivalent PROTACs
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal

Università degli Studi di Bologna, Italy
2018/10/01 - 2020/01/13 Anticancer Organoruthenium(II) Glycoconjugates: Tricks or Treats?
Supervisor
 Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/10/01 - 2019/03/22 NMR spectroscopy applied to process development for the synthesis of new drugs
Co-supervisor
 Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009/10/01 - 2010/07/31 Enantioselective synthesis of triptofanol-derived oxazolopiperidone lactams
Supervisor
 Master in Organic Chemistry (Master)
Universitat de Barcelona Facultat de Farmacia, Spain

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/12/19 Curcumin analogues: novel potential therapeutic agents for the treatment of neurodegenerative diseases
(Thesis) Arguer
 Marta Sofia dos Santos Soares Valente Clariano (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/12/20 Synthesis and evaluation of chemical probes to study the biology of liver stage malaria parasites
(Thesis) Arguer
 Joana Rita Leite Ribeiro (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/09/20 - Current Química Geral Ciências Farmacêuticas (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/09/15 - Current Introdução à síntese de fármacos Química Medicinal e Biofarmacêutica (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09/15 - Current Química Orgânica Ciências Farmacêuticas (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/18 - Current Química Orgânica II Ciências Farmacêuticas (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/12/20 - 2020/02/10 Drug Design/ Nucleic acids and inorganic anticancer agents Química Medicinal e Biofarmacêutica (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/10/01 - 2018/12/21 Química-Física Ciências Farmacêuticas (Licenciatura) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/03/15 - 2018/07/31 Princípios de Refinação de Petróleo Engenharia de Petróleos - Refinação (Licenciatura) Instituto Piaget, Portugal