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Ana Paula Francisco received her degree in Pharmaceutical Sciences in 1989. After graduation she moved to Biochemistry I group at LNETI-DTIC as Research fellow where she worked on the biological evaluation of liposomal formulations and the establishement of in vivo infectious and arthritis models. In 1991 she was contracted as Trainee assitant at Faculty of Pharmacy- University of Lisbon. In 2005 she obtained her PhD in triazene chemistry and in the development of mutual prodrugs for melanoma chemotherapy. During these years her research interests have been devoted to the study of prodrug chemistry, drug development, and study of physico-chemical and metabolic properties of drugs and prodrugs. More recently Ana Paula's research interests are the design and synthesis of new hybrid compounds with anticancer activity and the sudy of chemical and biological stability of drugs, prodrugs and other compounds with terapeutic utility . Other research interests are related with other collaborative and translational projects dedicated to the development or usage of diverse delivery systems that can be associated with active molecules and improve their pharmacological profile.
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Identification

Personal identification

Full name
Ana Paula Francisco

Citation names

  • Francisco, Ana
  • Francisco AP
  • Francisco APG

Author identifiers

Ciência ID
741E-ABD7-324A
ORCID iD
0000-0001-6602-2075
Researcher Id
M-4178-2013
Scopus Author Id
57237689900
Education
Degree Classification
2005
Concluded
 PhD in Pharmaceutical Chemistry and Therapeutics (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Mutual prodrugs of antitumour triazenes" (THESIS/DISSERTATION)
 Aproved with distinction and honour
1983/10 - 1989/06
Concluded
 Pharmaceutical Sciences-Chemical and Biological Analysis (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 fifteen in twenty (15/20)
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2005/02/17 - Current Assistant Professor (University Teacher) Universidade de Lisboa- Faculdade de Farmácia, Portugal
Universidade de Lisboa- Faculdade de Farmácia, Portugal
1995/12/21 - 2005/02/16 Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
1991/04/01 - 1995/12/20 Trainee Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
1989/07/17 - 1991/03/31 Research fellow LABORATÓRIO NACIONAL DE ENGENHARIA E TECNOLOGIA INDUSTRIAL, Portugal
Projects

Contract

Designation Funders
2017/10/01 - Current Uma nova arma na luta contra a tuberculose. Co-fármacos activados por esterases micobacterianas /A new approach to fight tuberculosis: co-drugs activated by mycobacterial esterases.
PTDC/SAUINF/ 28080/2017
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2017 - Current COMPOSTOS HÍBRIDOS NANOFORMULADOS PARA O DIRECCIONAMENTO ESPECÍFICO DE MELANOMA METASTÁTICO /NANOFORMULATED HYBRID MOLECULES FO R SPECIFIC TAREGETING MELANOMA METASTASIS
PTDC/MEDQUI/ 31721/2017
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2017 - Current Descoberta de fármacos inibidores de interacções proteína-proteína da p53/ Drug Discovery for p53 PPI Targets
PTDC/QUIQOR/ 29664/2017
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2013/06 - 2014/12 Exploring a new approach to target KRAS oncogene
Provided by PTCRIS: 126057
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1995/12/01 - 2005/02/16 Development of antitumor triazene prodrugs
Praxis XXI, proj. 2/2.1/SAU/1404/95
Researcher
Universidade de Lisboa- Centro de Estudos de Ciências farmacêuticas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Francisco AP; Ressurreição, Ana Sofia; Jesus Perry, M.; Lopes, Francisca. "Knorr Pyrazole Synthesis of Edaravone". 366-369. The Royal Society of Chemistry., 2016.
    Published
  2. Francisco AP; Lopes, Francisca; Perry, M.J.. "Preparation of Nitrostilbenes by the Wittig reaction". 623-626. The Royal Society of Chemistry, 2016.
    Published
  3. Ressurreição, AS; Perry, M.J.; Francisco AP; Lopes, Francisca. "Synthesis of Hippuric acid: an Example of Amide Bond Formation.". 147-150. London, United Kingdom: The Royal Society of Chemistry., 2016.
    Published
  4. Jesus Perry, M.; Francisco AP; Ressurreição AS; Lopes, F.. "Stereoselective Epoxidation of Cholesterol by m-Chloroperoxybenzoic Acid.". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, edited by Afonso CAM, 754-757. London, United Kingdom: The Royal Society of Chemistry., 2016.
    Published
  5. Mendes, Eduarda; Perry, M.J.; Francisco AP. "The synthetic utility of triazenes in heterocyclic synthesis in Heterocyclic Targets in Advanced Organic Synthesis". 125-144. Kerala, India: Research Signpost, 2011.
    Published
  6. Francisco, Ana Paula; Perry, Maria de Jesus; Moreira, Rui; Mendes, Eduarda. "Alkylating Agents". In Anticancer Therapeutics, 133-158. London, United Kingdom: John Wiley & Sons, Ltd, 2008.
    10.1002/9780470697047.ch9
Conference paper
  1. Perry MJ; Lopes F; Francisco AP; Madureira M; Moreira R; Fernandes D. "O ensino da Química Farmacêutica em tempos de pandemia: novas práticas pedagógicas impulsionadas pelo ensino à distância. No futuro, quais permanecerão?". Paper presented in Congresso Nacional de Práticas Pedagógicas no Ensino Superior, Aveiro, July 2021, Aveiro, 2021.
    Published
  2. Ribeiro IAC; Francisco AP; Guedes R; Mendes S; Bettencourt AF. "Formação em Ciências Farmacêuticas: os estudantes como atores na promoção da saúde.https://cnappes.org/cnappes-2017/files/2018/06/Livro_Atas_CNaPPES_2017.pdf". Paper presented in 4º Congresso de Práticas Pedagógicas no Ensino Superior. CNaPPES 2017, Setúbal, 2017.
    Published
Conference poster
  1. Eleuterio, Carla; Francisco AP; Calado S; Mendes E; Perry MJ; Gaspar MM. "Nanoformulations with specific affinity to human melanoma". Paper presented in 18th Meeting of the European Society for Pigment Cell Research Lisbon, Portugal | 9-12 September 2013, 2013.
    10.1111/pcmr.12152
Journal article
  1. Pinho, J.O.; Matias, M.; Marques, V.; Eleutério, C.; Fernandes, C.; Gano, L.; Amaral, J.D.; et al. "Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management". Biomedicine and Pharmacotherapy 157 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85141996153&partnerID=MN8TOARS.
    10.1016/j.biopha.2022.114021
  2. Pinho, J.O.; Matias, M.; Godinho-Santos, A.; Amaral, J.D.; Mendes, E.; Perry, M.J.; Francisco, A.P.; Rodrigues, C.M.P.; Gaspar, M.M.. "A step forward on the in vitro and in vivo assessment of a novel nanomedicine against melanoma". International Journal of Pharmaceutics 640 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85159150912&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2023.123011
  3. J. P. Pais; Margarida Policarpo; Pires D; Francisco AP; Ana Margarida Madureira; Bernard Testa; Anes, E; Luis Constantino. "Fluoroquinolone Derivatives in the Treatment of Mycobacterium tuberculosis Infection". Pharmaceuticals (2022): https://www.mdpi.com/1424-8247/15/10/1213.
    10.3390/ph15101213
  4. Rita M. Mendes; Ana P. Francisco; Filomena A. Carvalho; Maissa Dardouri; Bruna Costa; Ana F. Bettencourt; Judite Costa; et al. "Fighting S. aureus catheter-related infections with sophorolipids: Electing an antiadhesive strategy or a release one?". Colloids and Surfaces B: Biointerfaces (2021): https://doi.org/10.1016/j.colsurfb.2021.112057.
    10.1016/j.colsurfb.2021.112057
  5. Margarida Granada; Eduarda Mendes; Maria Jesus Perry; Maria João Penetra; Maria Manuela Gaspar; Jacinta O. Pinho; Sofia Serra; Catarina Teixeira António; Ana Paula Francisco. "Sulfur Analogues of Tyrosine in the Development of Triazene Hybrid Compounds: A New Strategy against Melanoma". ACS Medicinal Chemistry Letters (2021): https://doi.org/10.1021/acsmedchemlett.1c00252.
    10.1021/acsmedchemlett.1c00252
  6. Luciana Matos Alves Pinto; Oluwatomide Adeoye; Sérgio Scherrer Thomasi; Ana Paula Francisco; Helena Cabral-Marques. "A single-step multicomponent synthesis of a quinoline derivative and the characterization of its cyclodextrin inclusion complex". Journal of Molecular Structure 1237 (2021): 130391-130391. https://doi.org/10.1016/j.molstruc.2021.130391.
    10.1016/j.molstruc.2021.130391
  7. Pinto, Luciana Matos Alves; Adeoye, Oluwatomide; Thomasi, Sérgio Scherrer; Francisco, Ana Paula; Carvalheiro, Manuela Colla; Cabral-Marques, Helena. "Preparation and characterization of a synthetic curcumin analog inclusion complex and preliminary evaluation of in vitro antileishmanial activity". International Journal of Pharmaceutics 589 (2020): 119764. http://dx.doi.org/10.1016/j.ijpharm.2020.119764.
    Published • 10.1016/j.ijpharm.2020.119764
  8. Adeoye, Oluwatomide; Bártolo, Inês; Conceição, Jaime; da Silva, Andreia Bento; Duarte, Noélia; Francisco, Ana Paula; Taveira, Nuno; Cabral-Marques, Helena. "Pyromellitic dianhydride crosslinked soluble cyclodextrin polymers: Synthesis, lopinavir release from sub-micron sized particles and anti-HIV-1 activity". International Journal of Pharmaceutics 583 (2020): 119356. http://dx.doi.org/10.1016/j.ijpharm.2020.119356.
    10.1016/j.ijpharm.2020.119356
  9. Francisco, Ana P.; Mendes, Eduarda; Santos, Ana R.; Perry, Maria J.. "Anticancer Triazenes: from Bioprecursors to Hybrid Molecules". Current Pharmaceutical Design 25 14 (2019): 1623-1642. http://dx.doi.org/10.2174/1381612825666190617155749.
    10.2174/1381612825666190617155749
  10. Faustino, Célia; Francisco, Ana P.; Isca, Vera M. S.; Duarte, Noélia. "Cytotoxic Stilbenes and Derivatives as Promising Antimitotic Leads for Cancer Therapy". Current Pharmaceutical Design 24 36 (2019): 4270-4311. http://dx.doi.org/10.2174/1381612825666190111123959.
    10.2174/1381612825666190111123959
  11. Sousa, A.; Santos, F.; Gaspar, M.M.; Calado, S.; Pereira, J.D.; Mendes, E.; Francisco, A.P.; Perry, M.J.. "The selective cytotoxicity of new triazene compounds to human melanoma cells". Bioorganic and Medicinal Chemistry (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85020296185&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.04.049
  12. Gaspar, Maria Manuela; Calado, S; Eleuterio, carla. "Nanoformulations of a Triazene Analogue with Specific Affinity to Human Melanoma". Journal of Nanoscience with Advanced Technology 1 4 (2016): 1-9. http://dx.doi.org/10.24218/jnat.2016.16.
    10.24218/jnat.2016.16
  13. Francisco, A.P.; Paulo, A.. "Oncogene expression modulation in cancer cell lines by DNA G-quadruplex-interactive small molecules". Current Medicinal Chemistry 23 30 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85010066695&partnerID=MN8TOARS.
    10.2174/0929867323666160829145055
  14. Brito, H.; Martins, A.C.; Lavrado, J.; Mendes, E.; Francisco, A.P.; Santos, S.A.; Ohnmacht, S.A.; et al. "Targeting KRAS oncogene in colon cancer cells with 7-carboxylate Indolo[3,2-b] quinoline tri-alkylamine derivatives". PLoS ONE 10 5 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84934910595&partnerID=MN8TOARS.
    10.1371/journal.pone.0126891
  15. Rijo, P.; Duarte, A.; Francisco, A.P.; Semedo-Lemsaddek, T.; Simóes, M.F.. "In vitro antimicrobial activity of royleanone derivatives against gram-positive bacterial pathogens". Phytotherapy Research 28 1 (2014): 76-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892438836&partnerID=MN8TOARS.
    10.1002/ptr.4961
  16. Mendes, E.; Perry, M.D.J.; Francisco, A.P.. "Design and discovery of mushroom tyrosinase inhibitors and their therapeutic applications". Expert Opinion on Drug Discovery 9 5 (2014): 533-554. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899116068&partnerID=MN8TOARS.
    10.1517/17460441.2014.907789
  17. Matos, A.M.; Francisco, A.P.. "Targets, structures, and recent approaches in malignant melanoma chemotherapy". ChemMedChem 8 11 (2013): 1751-1765. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890879302&partnerID=MN8TOARS.
    10.1002/cmdc.201300248
  18. Monteiro, A.S.; Almeida, J.; Cabral, G.; Severino, P.; Videira, P.A.; Sousa, A.; Nunes, R.; et al. "Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines". European Journal of Medicinal Chemistry 70 (2013): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885368654&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.09.040
  19. Carmo Carreiras, M.; Mendes, E.; Jesus Perry, M.; Francisco, A.P.; Marco-Contelles, J.. "The multifactorial nature of Alzheimer's disease for developing potential therapeutics". Current Topics in Medicinal Chemistry 13 15 (2013): 1745-1770. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887972850&partnerID=MN8TOARS.
  20. Capucha, V.; Mendes, E.; Francisco, A.P.; Perry, M.J.. "Development of triazene prodrugs for ADEPT strategy: New insights into drug delivery system based on carboxypeptidase G2 activation". Bioorganic and Medicinal Chemistry Letters 22 22 (2012): 6903-6908. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867847410&partnerID=MN8TOARS.
    10.1016/j.bmcl.2012.09.029
  21. Rijo, P.; Simões, M.F.; Francisco, A.P.; Rojas, R.; Gilman, R.H.; Vaisberg, A.J.; Rodríguez, B.; Moiteiro, C.. "Antimycobacterial metabolites from Plectranthus: Royleanone derivatives against Mycobacterium tuberculosis strains". Chemistry and Biodiversity 7 4 (2010): 922-932. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951197862&partnerID=MN8TOARS.
    10.1002/cbdv.200900099
  22. Perry, M.J.; Mendes, E.; Simplício, A.L.; Coelho, A.; Soares, R.V.; Iley, J.; Moreira, R.; Francisco, A.P.. "Dopamine- and tyramine-based derivatives of triazenes: Activation by tyrosinase and implications for prodrug design". European Journal of Medicinal Chemistry 44 8 (2009): 3228-3234. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349149632&partnerID=MN8TOARS.
    10.1016/j.ejmech.2009.03.025
  23. Carvalho, E.; Francisco, A.P.; Iley, J.; Rosa, E.. "The mechanism of hydrolysis of aryl ether derivatives of 3-hydroxymethyltriazenes". European Journal of Organic Chemistry 10 (2005): 2056-2063. http://www.scopus.com/inward/record.url?eid=2-s2.0-20044385636&partnerID=MN8TOARS.
    10.1002/ejoc.200400582
  24. Carvalho, E.; Francisco, A.P.; Iley, J.; Rosa, E.. "Triazene drug metabolites. Part 17: Synthesis and plasma hydrolysis of acyloxymethyl carbamate derivatives of antitumour triazenes". Bioorganic and Medicinal Chemistry 8 7 (2000): 1719-1725. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033932405&partnerID=MN8TOARS.
    10.1016/S0968-0896(00)00100-0
  25. Corvo, M.L.; Martins, M.B.; Francisco, A.P.; Morais, J.G.; Cruz, M.E.M.. "Liposomal formulations of Cu,Zn-superoxide dismutase: Physicochemical characterization and activity assessment in an inflammation model". Journal of Controlled Release 43 1 (1997): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031060394&partnerID=MN8TOARS.
    10.1016/S0168-3659(96)01473-3
  26. Mimoso, I.M.; Francisco, A.P.G.; Cruz, M.E.M.. "Liposomal formulation of netilmicin". International Journal of Pharmaceutics 147 1 (1997): 109-117. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030894425&partnerID=MN8TOARS.
    10.1016/S0378-5173(96)04807-7
  27. Fernandes, L.; Francisco, A.P.; Iley, J.; Rosa, E.. "Triazene drug metabolites. Part 14. Kinetics and mechanism of the acid-catalysed hydrolysis of 3-alkoxymethyl-3-alkyl-1-aryltriazenes". Journal of the Chemical Society, Perkin Transactions 1 11 (1994): 2313-2317. http://www.scopus.com/inward/record.url?eid=2-s2.0-2142736924&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Francisco AP. "Mutual prodrugs of antitumour triazenes". PhD, Universidade de Lisboa- Faculdade de Farmácia, 2005.

Intellectual property

Patent
  1. Francisco AP; Cruz MEM; Carvalhosa IMAN. 1993. "Liposomal aminoglycoside compositions and process for their preparation. WO 1993023015 A1".
  2. Francisco AP; Cruz Maria Eugénia M; Mimoso, IM. 1992. "Formulações Lipossomais de Aminoglucósidos e Processo para a sua Preparação. Patente Nacional nº100486".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/11 Using sophorolipids as an antiadhesive or release strategy to fight S. aureus catheter-related infection
7th International Electronic Conference on Medicinal Chemistry session Round table on infectious diseases.
2020/11 A Novel Nanoformulated Hybrid Molecule as a Promising Strategy for the Treatment of Melanoma
Ordem dos Farmacêuticos (Lisboa, Portugal)
2019/01/23 A nanotechnological approach to improve the therapeutic efficacy of cytotoxic agents against melanoma 2nd SPLC-CRS Young Scientists Meeting,
CRS Spanish -Portuguese (Santiago de Compostela, Spain)
2018/07/29 Toward triazene-hybrid molecules with improved melanocytotoxic activity- Chemistry at ULisboa & 2018 Summer School
Colégio da Química (Lisboa, Portugal)
2017/07/21 Dual-action triazene prodrugs as potent antimelanoma agents 1.º Encontro do Colégio de Química (1ECQUL)
Colégio da Química (Lisboa, Portugal)
2017/07/21 Targeting Oncogene Expression with small molecules 1.º Encontro do Colégio de Química (1ECQUL)
Colégio da Química (Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/05/31 - Current Funcionalização de alcaloides indólicos obtidos de uma planta medicinal Africana
Co-supervisor
 Master in Medicinal and Biopharmaceutical Chemistry (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2021/10 - 2023/04/28 Synthesis of different triazene derivatives and evaluation of their activity against uropathogens
Co-supervisor of Pedro Miguel Ascenso Vieira
 Master in Bioorganic Chemistry- FCT-UNL (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2021/10 - 2023/02/06 Desenvolvimento de compostos antitumorais direcionados para o combate do melanoma metastático/ Development of targeted anticancer compounds against metastatic melanoma
Supervisor of Keisly Coromoto Da Costa Peña
 Master in Medicinal and Biopharmaceutical Chemistry (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2020/10 - 2022/11/11 Pro-farmacos contendo álcoois de cadeia longa para tratamento da tuberculose. Investigação do mecanimo de ação
Co-supervisor of Olha Antoniuk
 Master in Medicinal and Biopharmaceutical Chemistry (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2020/10 - 2022/02 Novel p53 activators for anticancer therapy
Co-supervisor of Ricardo João Freitas Ferreira
 Master in Medicinal and Biopharmaceutical Chemistry (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2019/10 - 2021/04 Síntese e avaliação biológica de novos compostos antitumorais derivados de triazenos
Supervisor of Catarina Teixeira António
 Master in Pharmaceutical and Medicinal Chemistry (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2018/10 - 2020/07 Síntese e avaliação de novas moléculas híbridas para o tratamento do melanoma maligno metastático
Supervisor of Sofia Gomes Serra
 Master in Pharmaceutical and Medicinal Chemistry (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2018/10 - 2020/07 Uma nova abordagem na obtenção de fármacos ativos contra a tuberculose: co-fármacos activados por esterases micobacterianas
Co-supervisor of Margarida Vieira Policarpo
 Master in Pharmaceutical and Medicinal Chemistry (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2016/10 - 2018/07 Desenvolvimento de moléculas híbridas para o tratamento do melanoma maligno metastático
Supervisor of Andreia Filipa Alcanena Gonçalves
 Master in Pharmaceutical and Medicinal Chemistry (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2013 Desenvolvimento de pró -fármacos de triazenos antitumorais para o tratamento do melanoma maligno metastático
Co-supervisor of Ana Margarida Colaço Granada
 Master in Pharmaceutical and Medicinal Chemistry (Master)
Universidade de Lisboa- Faculdade de Farmácia, Portugal
2011 - 2012 Triazene Prodrug Synthesis for MDEPT strategy and their hepatotoxic evaluation
Supervisor of Fábio Miguel Figueiredo Santos
 Master in Pharmaceutical and Medicinal Chemistry (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2008 - 2010 Desenvolvimento de pró-fármacos de triazenos antitumorais para aplicação em estratégias ADEPT: Activação pela carboxipeptidase G2
Co-supervisor of Verónica Teixeira Antunes Capucha
 Master in Pharmaceutical and Medicinal Chemistry (Master)
University of Lisbon- Faculty of Pharmacy, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/11/30 Validation of a novel hybrid nanosystem integrating cytotoxic and magnetic properties as a tool to potentiate the antitumour activity
(Thesis) Main arguer
 Afonso Toledo Azevedo (Master)
Nova University of Lisbon- School of Science and Technology, Portugal
2023/11/25 Desenvolvimento de pró-fa´rmacos contendo grupos foto-protetores
(Thesis) Arguer
 Maria Salma Quintal Awam (Master)
2023/11/24 Exploring Silicone Functionalization with Surfactin Towards the Improvement of Medical Devices antimicrobial Properties
(Thesis) Arguer
 Madalena Gonçalves Lourenço (Master)
2023/11 Abordagens a seguir na prevenção e controlo da infeção hospitalar:presente e futuro
(Thesis) Main arguer
 Rita Andrea Matias Lucas (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2023/07/21 Development of Drugs to treat tuberculosis targeting dprE1
(Thesis) Arguer
 Raquel Silva (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2022/12 EXPLORING YEAST AND BACTERIA SECONDARY METABOLITES FOR THE DEVELOPMENT OF ANTIMICROBIAL HYDROGEL FORMULATIONS
(Thesis) Main arguer
 Francisco Antunes Narciso (Master)
2021/11 Studies of a mutp53 Reactivator and Synthesis of its Metabolite
(Thesis) Arguer
 Adriana Margarida Duarte e Silva (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2021/09 Cancer chemotherapeutic agents using a nanotechnological approach
Thesis Member
 Jacinta de Oliveira Pinho (PhD)
University of Lisbon- Faculty of Pharmacy, Portugal
2021/07/14 Avanços Terapêuticos na Doença de Alzheimer
Supervisor
 Rita Montalto Rosado (Master)
Universidade de Lisboa- Faculdade de Farmácia, Portugal
2021/07/14 Avanços Terapêuticos no Melanoma Maligno Metastático
Supervisor
 Joana Guerreiro Serrudo Monografia (Master)
Universidade de Lisboa- Faculdade de Farmácia, Portugal
2021/07/14 Avanços Terapêuticos na Tuberculose
Supervisor
 Andreia Nicole Vieira de Jesus (Master)
Universidade de Lisboa- Faculdade de Farmácia, Portugal
2021/07/13 Doença de Crohn: terapêutica e perspetivas futuras
(Thesis) Main arguer
 Tânia Sofia Alves Pinto Mendonça (Master)
Universidade de Lisboa- Faculdade de Farmácia, Portugal
2020/12 Avanços e perspectivas no combate ao melanoma maligno
(Thesis) Main arguer
 Sofia Gomes Martinho (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2020/12 Rhamnolipids: choosing Burkholderia thailandensis for antimicrobial glycolipids synthesis
(Thesis) Main arguer
 Igor Alexandre Rodrigues Correia (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2020/12 Prevenção de Infeções Associadas a Dispositivos Médicos
(Thesis) Main arguer
 Daniela Pereira Gaspar (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2019/07 Targeting the ubiquitin-proteasome system: Four-membered ring inhibitors of proteasome
(Thesis) Arguer
 Maryam Heydarpour klidsar (Master)
Universidade de Lisboa- Faculdade de Farmácia, Portugal
2019 DISCOVERY AND DEVELOPMENT OF NOVEL SMALL-MOLECULE IMMUNE SYSTEM MODULATORS
Thesis Member
 Ana Rita de Carvalho Acúrcio (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 TARGETING p53 WITH INDOLE-BASED COMPOUNDS
(Thesis) Arguer
 Raquel Alexandra Temporão Mestre (Master)
Universidade de Lisboa- Faculdade de Farmácia, Portugal
2017/05/31 INDOLE ALKALOIDS AS LEADS FOR DEVELOPING EFFECTIVE ANTICANCER DRUGS TARGETING MULTIDRUG RESISTANT CANCER CELLS
Thesis Member
 Angela Paterna (PhD)
Universidade de Lisboa- Faculdade de Farmácia, Portugal
2016/03/11 Medicinal Chemistry Approaches to Malaria Drug Discovery
Thesis Member
 Sofia Alexandre Santos (PhD)
Universidade de Lisboa- Faculdade de Farmácia, Portugal
2016 Development of alkylating hybrid molecules of triazenes for the treatment of glioma
(Thesis) Arguer
 Cláudia Marisa Fernandes Braga (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/01 Ligandos selectivos de G-quadruplexes de ADN para terapia do cancro: derivados de indolo[3,2-b]quinolinas
(Thesis) Arguer
 Ana Cláudia Bernardes Martins (Master)
University of Lisbon- Faculty of Pharmacy, Portugal
2013/12/20 Desenvolvimento de ferramentas químicas para estudar o mecanismo de acção de novas 4-aminoquinazolinas como inibidores da fase hepática da malária
(Thesis) Arguer
 André Filipe Raposo Moreira Dias (Master)
Universidade de Lisboa- Faculdade de Farmácia, Portugal
2013/01/06 Ligandos selectivos de G-quadruplexes de ADN para a terapia do cancro
(Thesis) Arguer
 Ana Cláudia Bernardes Martins (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 Estudo do efeito anti-tumoral dos pró-fármacos de triazenos em linhas celulares de melanoma
(Thesis) Arguer
 Joana Nabais Freitas de Almeida (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 Phytochemical Study and Biological Activities of Diterpenes and Derivatives from Plectranthus Species
Thesis Member
 Patrícia Dias de Mendonça Rijo (PhD)
Universidade de Lisboa- Faculdade de Farmácia, Portugal
2010/03 Optimização de N. 1. -alquil-ß-lactamas Como Inibidores. Irreversíveis de Proteases de Serina
Thesis Member
 Ana Bela Fernandes Santana (PhD)
University of Lisbon- Faculty of Pharmacy, Portugal
2010/02 “beta-Lactamas como inibidores de proteases de serina e activação de pró-fármacos por esterases
Thesis Member
 Emilia Alice dos Reis Torroaes Valente (PhD)
University of Lisbon- Faculty of Pharmacy, Portugal
2009 Pró-fármacos de triazenos anti-tumorais para estudos ADEPT e MDEPT
(Thesis) Arguer
 Ana Sofia Abrantes Monteiro (Master)
Universidade de Lisboa- Faculdade de Ciências, Portugal
2006/11 Novel steroidal derivatives linked to biological active moieties
Thesis Member
 Goreti de Jesus Ribeiro Morais (PhD)
Universidade de Lisboa- Faculdade de Farmácia, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/06/16 - 2021/07/07 Evaluation of best poster presentation in iMed.ULisboa meeting 2021
Evaluator
 Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal Universidade de Lisboa Instituto de Investigação do Medicamento

Mentoring / Tutoring

Topic Student name
2022/02 - Current Monograph Master in Pharmaceutical Sciences Sofiya Masna
2021/12 - Current Monograph Master in Pharmaceutical Sciences Maria João Claré Fanica
2022/01/04 - 2022/09/23 Monograph Master in Pharmaceutical Sciences Raquel Sofia Direitinho Pedras
2021/02 - 2021/11 Synthesis of 1H-pyrrolo[3,2-c]quinolines as scaffolds for biologically active compounds Joana Guerreiro Galla Goucha Jorge (Erasmus Student)
2021/02/14 - 2021/07 Monograph Master in Pharmaceutical Sciences Rita Montalto Rosado
2021/02/14 - 2021/07 Monograph Master in Pharmaceutical Sciences Joana Guerreiro Serrudo
2021/02/14 - 2021/07 Monograph Master in Pharmaceutical Sciences Andreia Nicole Vieira de Jesus
2020/10 - 2021/02 Synthesis and Biological Evaluation of a Hybrid Compound as Tyrosinase substrate for the Treatment of Metastatic Melanoma, Carolina Pinto
2020/03/01 - 2020/11/19 Master in Pharmaceutical Sciences (thesis) Daniela Sofia Costa Nascimento
2020/03/01 - 2020/11/19 Monograph Master in Pharmaceutical Sciences Mariana Lobo Pereira
2020/03/01 - 2020/11/19 Monograph Master in Pharmaceutical Sciences Rita Miguel Baltazar Medinas dos Santos Borrego
2019/10 - 2020/02 Síntese e Avaliação de novos compostos híbridos anticancerígenos Daniela Sofia Costa Nascimento
2019/10 - 2020/02 Síntese e Estudo de Estabilidade de um Composto Híbrido com Potencial Aplicação no melanoma Bárbara Sofia Rodrigues Lavradorinho
2019/02 - 2019/09 Recently developed novel drugs for systemic therapy of malignant melanoma Sofia Ribeiro da Cruz
2019 - 2019 Monograph Master in Pharmaceutical Sciences Débora Reis Veiga de Almeida
2019 - 2019 Preparation of (tentative) metabolites (sulfates and/or glucuronides) of natural phenolic compounds such as flavonoids and flavonolignans. Aryl-sulfotransferases and their application in the preparation of sulfated metabolites Andreia Sofia Rodrigues Delgado (Erasmus student)
2018/02 - 2018/07 Parkinson disease: traditional therapeutics and recent developments Marta Sofia dos Santos Soares Valente Clariano
2018 - 2018 "Doenças da próstata:tratamento farmacológico e novos fármacos em estudo Integrated Master in Pharmaceutical Sciences Joana Margarida de Castro Ferreira,
2018 - 2018 Monograph Master in Pharmaceutical Sciences Galina Igorevna Ivanova
2018 - 2018 Synthesis of important building blocks for different xanthines, SDZ 220.040 and oxyphenbutazone derivatives Angela Beatriz de Moura e Pereira (Erasmus student)
2018 - 2018 Synthesis of benzothiazole scaffold based DNA gyrase B inhibitors" Miguel Alexandre de Oliveira Passos Serafim dos Santos (Erasmus Student)
2017/02 - 2017/09 In vitro and in vivo activity of a new hybrid molecule incorportaed in liposomes against melanoma” Catarina Mourato Cândido,
2017/02 - 2017/07 Development of cryptolepine-like compounds as fluorescente probes Miguel Soares
2016/10 - 2017/03 Synthesis of Indolo[3,2-b]quinolines functionalised with specific linkers as possible activity-based probes for live cell imaging Mattia Mazza
2017 - 2017 Monograph Master in Pharmaceutical Sciences Cristiana Cardoso Dias
2017 - 2017 Monograph Master in Pharmaceutical Sciences Rita Alexandra Lampreia Dias
2017 - 2017 Monograph Master in Pharmaceutical Sciences Joana Isabel Belo de Sousa e Araújo Meira,
2017 - 2017 Monograph Master in Pharmaceutical Sciences Ana Rita Custódio Santos
2017 - 2017 New photochemical cross coupling reactions to prepare esters from aldheydes and alchools Inês Alexandra Monteiro Raposo (Erasmus students)
2016/02 - 2016/09 Hybrid molecules with cytotoxic effect against cancer cells Catarina Mourato Cândido
2016/02 - 2016/09 Compostos híbridos: uma estratégia promissora para descobrir novos fármacos antitumorais Sofia Batanete
2016 - 2016 Monograph Master in Pharmaceutical Sciences Ana Catarina Pinheiro Apura
2016 - 2016 Monograph Master in Pharmaceutical Sciences Joana da Conceição Pereira
2016 - 2016 Síntese e avaliação de substâncias que interagem com os receptores b3-adrenérgicos Sofia Aguiar Fernandes (Erasmus student)
2015/02 - 2015/07 “Estudos computacionais para o desenvolvimento de pró-fármacos híbridos no melanoma David Tibério
2015 - 2015 Monograph Master in Pharmaceutical Sciences Alexandra Isabel Balseiro da Luz
2015 - 2015 Monograph Master in Pharmaceutical Sciences Nadi Monteiro de Aguiar
2014/02 - 2014/07 Synthesis of compounds with antimalarial activity Salvatore Mattiolo
2014/02 - 2014/07 Transportadores de péptidos como alvos terapêuticos em química medicinal Pedro Santos Gonçalves
2013/10 - 2014/02 Synthesis of compounds with potential antimalarial activity – Rafael Filipe Teixeira Arbuéz Gomes
2014 - 2014 Monograph Master in Pharmaceutical Sciences Maria Oliveira Costa Almeida Atanásio
2014 - 2014 Monograph Master in Pharmaceutical Sciences Ana Isabel Pereira Afonso
2014 - 2014 Monograph Master in Pharmaceutical Sciences Liliane Alves Pereira
2014 - 2014 Synthesis of 5-aryl-imidazo[2,1-b]thiazole compounds possibly RAF kinase inhibitors Mário Rui Dias Almeida
2013 - 2013 Analysis of tricarboxylic acids in cancer by LC-MS” Marta de Oliveira Pimentel Rosado Rico (Erasmus student)
2012/02 - 2012/07 Alvos Moleculares com potencial interesse no tratamento do melanoma maligno metastático Ana Marta Matos
2011/10 - 2012/02 Síntese de potenciais pró-fármacos para aplicação em MDEPT Sofia Costa Farelo Ataíde Marques
2011/10 - 2012/02 Síntese de um potencial pró-fármaco para aplicação em MDEPT Henrique Avelar Costa Freire Correia
2012 - 2012 Monograph Master in Pharmaceutical Sciences Joana Margarida Ferreira Páscoa
2012 - 2012 Monograph Master in Pharmaceutical Sciences Marisa Sousa Miguel
2012 - 2012 Monograph Master in Pharmaceutical Sciences Pedro Miguel Marques Afonso
2011/02 - 2011/07 Síntese de pró-fármacos de triazenos usando aminoácidos como transportadores Marta-Alexandra Bogalho Rodrigues Carvalho
2011/02 - 2011/07 Lipossomas como sistemas de vectorização de fármacos para tratamento do melanoma maligno Laurinda Alves
2009/10 - 2011/07 Síntese e estudos de estabilidade de um pró-fármaco de triazeno para aplicação no tratamento do melanoma maligno Marta-Alexandra Bogalho Rodrigues Carvalho
2010/10 - 2011/02 Síntese e estudo cinético de pró-fármacos de triazenos contendo um fenol como transportador João Diogo Fonseca Marques Pereira
2010/02 - 2010/07 Síntese de um potencial pró-fármaco para aplicação em MDEPT Adriana Maria Nunes Costa
2010/02 - 2010/07 Síntese e estudo de estabilidade de um potencial pró-fármaco para aplicação em MDEPT Marlen Borges Medeiros
2010/02 - 2010/07 Avanços recentes na utilização de pró-fármacos dirigidos para a célula tumoral Fábio Miguel Figueiredo Santos
2009/02 - 2009/05 Development of prodrugs of triazenes able to be used in an ADEPT approach Andrea Dorová
2008/02 - 2008/07 Síntese de um pró-fármaco de triazeno e avaliação da sua toxicidade em células de melanoma Inês Patricia Félix Oliveira
2008 - 2008 Monograph Master in Pharmaceutical Sciences Elsa de Jesus Baptista Ferrão
2008 - 2008 Monograph Master in Pharmaceutical Sciences Rui Pedro Pinheiro Gonçalves Marques

Other jury / evaluation

Activity description Institution / Organization
2023/09/19 - Current Arguer of first year PhD course evaluation of Filipa Daniel Freitas Barbosa University of Lisbon- Faculty of Pharmacy, Portugal
Distinctions

Award

2020 BInov-Scientific society award -Ordem dos Farmacêuticos
Ordem dos Farmaceuticos, Portugal

Other distinction

2020 Best oral communication
Congresso nacional dos Farmacêuticos, Portugal
2018 Distinguished flash presentation-3rd Meeting of the College of Chemistry -2018
University of Lisbon- Chemistry College, Portugal
1997 Grant to participate in the Postgraduate Winter School on Organic Reactivity ,
1990 Grant to participate in "Vaccines- Recent Trends and Progress"