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Identification

Personal identification

Full name
Catarina Tomé

Citation names

  • Tomé, C. S.

Author identifiers

Ciência ID
7513-AF0E-65BB
ORCID iD
0000-0002-8456-4078
Scopus Author Id
57211059467

Knowledge fields

  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2017/03/01 - 2019/10/31
Concluded
Postdoc (Pós-doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/11/01 - 2016/12/05
Concluded
PhD in Biophysics (Doutoramento)
Université Grenoble Alpes, France

Institut de Biologie Structurale, France
"Understanding ribosome binding interactions and conformational changes of the EngA bacterial GTPase, a potential target for new antibiotics" (THESIS/DISSERTATION)
2007/09/01 - 2013/01/23
Concluded
MSc in Pharmaceutical Sciences (Mestrado integrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Evaluation of the effect of TPMT and XO inhibitors on 6-mercaptopurine cytotoxicity in human lymphoblastoid cell lines" (THESIS/DISSERTATION)
15 (out of 20)
Affiliation

Science

Category
Host institution
Employer
2019/11/01 - 2021/10/03 Contracted Researcher (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/03/01 - 2019/10/31 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/11/01 - 2016/12/31 Research Assistant (Research) Commissariat à l’énergie atomique et aux énergies alternatives, France
Institut de Biologie Structurale, France

Teaching in Higher Education

Category
Host institution
Employer
2014/09/01 - 2016/07/31 Assistant (University Teacher) Université Grenoble Alpes, France
Université Grenoble Alpes, France

Others

Category
Host institution
Employer
2020/10 - 2021/03 Maternity leave N/A, Portugal
Outputs

Publications

Book chapter
  1. Giuffrè, A.; Tomé, Catarina; Fernandes, D.G.F.; Zhura, K.; Vicente, J.B.. "Hydrogen Sulfide Metabolism and Signaling in the Tumor Microenvironment". In Tumor Microenvironment - The main driver of metabolic adaptation, 335-353. Advances in Experimental Medicine and Biology - Springer, 2020.
    Published • 10.1007/978-3-030-34025-4_17
Conference abstract
  1. Tomé, Catarina (7513-AF0E-65BB); Giuffrè, Alessandro; Brito, José; Vicente, João B.. "Poster presentation: Structural insights into the regulation and inhibition of human cystathionine ß-synthase". Paper presented in 19th Biennial Meeting for the Society for Free Radical Research International (SFRRI), Lisbon, 2018.
    Published • 10.1016/j.freeradbiomed.2018.04.524
  2. Tomé, Catarina; Foucher, Anne-Emmanuelle; Boumendjel, Ahcène; Neumann, Emmanuelle; Jault, Jean-Michel; Housset, Dominique. "Oral presentation: Probing nucleotide-induced conformational changes and interaction studies of the GTPase EngA". Paper presented in 30th European Crystallography Meeting, Basel, 2016.
    Published • 10.1107/S2053273316099563
Conference poster
  1. Tomé, Catarina; Lopes, R.; Leandro, J.; Amaro, M.P.; Mertens, H.D.T.; Sousa, P.M.F.; Leandro, P.; Vicente, J.B.. "Structure of full-length human phenylalanine hydroxylase reveals substrate-induced conformational stability". Paper presented in Instruct Biennial Structural Biology Meeting 2019, 2019.
  2. Tomé, Catarina; Foucher, Anne-Emmanuelle; Boumendjel, Ahcène; Jault, Jean-Michel; Housset, Dominique. "Structural and Functional Studies of B. subtilis GTPase YphC". Paper presented in Instruct Biennial Structural Biology Meeting 2015, 2015.
Journal article
  1. Tomé, C. S.. "Human Cystathionine ¿-Lyase Is Inhibited by s-Nitrosation: A New Crosstalk Mechanism between NO and H2S". Antioxidants 10 9 (2021): 1391-1391. http://dx.doi.org/10.3390/antiox10091391.
    10.3390/antiox10091391
  2. Pavlu-Pereira, Hana; Lousa, Diana; Tomé, Catarina S.; Florindo, Cristina; Silva, Maria João; de Almeida, Isabel Tavares; Leandro, Paula; Rivera, Isabel; Vicente, João B.. "Structural and functional impact of clinically relevant E1a variants causing pyruvate dehydrogenase complex deficiency". Biochimie (2021): http://dx.doi.org/10.1016/j.biochi.2021.02.007.
    In press • 10.1016/j.biochi.2021.02.007
  3. Zuhra, Karim; Tomé, Catarina S.; Forte, Elena; Vicente, João B.; Giuffrè, Alessandro. "The multifaceted roles of sulfane sulfur species in cancer-associated processes". Biochimica et Biophysica Acta (BBA) - Bioenergetics 1862 2 (2021): 148338. http://dx.doi.org/10.1016/j.bbabio.2020.148338.
    Published • 10.1016/j.bbabio.2020.148338
  4. Lopes, R.R.; Tomé, C. S.; Russo, R.; Paterna, R.; Leandro, J.; Candeias, N.R.; Gonçalves, L.M.D.; et al. "Modulation of human phenylalanine hydroxylase by 3-hydroxyquinolin-2(1H)-ones derivatives". Biomolecules 11 3 (2021): 462.
    Published
  5. Tomé, C.S.; Lopes, R.R.; Sousa, P.M.F.; Amaro, M.P.; Leandro, J.; Mertens, H.D.T.; Leandro, P.; Vicente, J.B.. "Structure of full-length wild-type human phenylalanine hydroxylase by small angle X-ray scattering reveals substrate-induced conformational stability". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-49944-x..
    Published • 10.1038/s41598-019-49944-x
  6. Inês Santos; Cristiano Manuel Colaço Ramos; Cindy Mendes; Catarina O. Sequeira; Catarina da Silveira Tomé; Dalila G.H. Fernandes; Pedro Barbosa Mota; et al. "Targeting Glutathione and Cystathionine ß-Synthase in Ovarian Cancer Treatment by Selenium–Chrysin Polyurea Dendrimer Nanoformulation". Nutrients 11 10 (2019): https://www.mdpi.com/2072-6643/11/10/2523.
    Published • 10.3390/nu11102523
  7. Zuhra, Karim; Tomé, Catarina S.; Masi, Letizia; Giardina, Giorgio; Paulini, Giulia; Malagrinò, Francesca; Forte, Elena; Vicente, João B.; Giuffrè, Alessandro. "N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells". Cells 8 8 (2019): http://dx.doi.org/10.3390/cells8080828.
    Published • 10.3390/cells8080828
  8. da Silveira Tomé, C.; Foucher, A.-E.; Jault, J.-M.; Housset, D.. "High concentrations of GTP induce conformational changes in the essential bacterial GTPase EngA and enhance its binding to the ribosome". FEBS Journal 285 1 (2018): 160-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-85036496326&partnerID=MN8TOARS.
    Published • 10.1111/febs.14333
Thesis / Dissertation
  1. Tomé, Catarina. "Understanding ribosome binding interactions and conformational changes of the EngA bacterial GTPase, a potential target for new antibiotics". PhD, Université Grenoble Alpes, 2016.
  2. Tomé, Catarina. "Evaluation of the effect of TPMT and XO inhibitors on 6-mercaptopurine cytotoxicity in human lymphoblastoid cell lines". Master, Universidade de Lisboa Faculdade de Farmácia, 2013.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/09 Structural insights into the allosteric substrate activation of the human enzyme phenylalanine hydroxylase NOVA Biophysica
(Lisbon, Portugal)
2016/12 Ribosome binding and conformational changes of the EngA bacterial GTPase Structural Biology meets Biophysics (SFB-GTBio)
(Obernai, France)
2016/08 Probing nucleotide-induced conformational changes and interaction studies of the GTPase EngA 30th European Crystallography Meeting
European Crystallography Association (Basel, Switzerland)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2019/12 - 2021/01/29 «Enzyme stabilizing by small molecules targeting the catalytic binding pockets». Supervisor: Prof. Dra. Ana Paula Leandro (FFULisboa)
Co-supervisor of Rita de Sousa Saraiva da Costa
Ciências Biofarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2019/05/12 - 2019/05/18 Training Course: «Chemistry of Metals in Biological Systems»
Workshop
TIMB3 1st Training School Chemistry of Metals in Biological Systems
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/04/05 - 2018/04/06 Practical Course: «Fragment Screening Using Crystallography Laboratory Equipment»
Workshop
Instruct/CIISB Course on Fragment Screening Using Crystallography Laboratory Equipment
Instruct-ERIC, United Kingdom
2017/09/11 - 2017/09/15 Practical Course: «Small Angle Neutro and X-Ray Scattering from Proteins in Solution»
Workshop
Small Angle Neutro and X-Ray Scattering from Proteins in Solution
European Molecular Biology Organization (EMBO), Germany
2015/05/24 - 2015/05/29 Practical Course: «International School on Biological Crystallization»
Workshop
International School on Biological Crystallization (ISBC2019)
Laboratorio de Estudios Cristalográficos, Spain
2014/07/07 - 2014/08/01 Summer School: «Integrated Structural and Cell Biology, From Molecules to Cells to Organisms: Thinking Out of the Box»
Workshop
Integrated Structural and Cell Biology, From Molecules to Cells to Organisms: Thinking Out of the Box
Université Grenoble Alpes École de Physique des Houches, France

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2021/01/29 «Enzyme stabilizing by small molecules targeting the catalytic binding pockets»
Thesis Member
Rita de Sousa Saraiva da Costa (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2014/09/01 - 2016/07/31 Cell Biology (Licence) Université Grenoble Alpes, France
2014/09/01 - 2016/07/31 Enzymology (Licence) Université Grenoble Alpes, France