Identification
Personal identification
- Full name
- Adriana Isabel do Vale Marcelo
Citation names
- Marcelo, Adriana
Author identifiers
- Ciência ID
- 7613-00C2-1621
- ORCID iD
- 0000-0002-7327-0170
Email addresses
- adrianamarcelo11@hotmail.com (Professional)
Knowledge fields
- Medical and Health Sciences - Basic Medicine - Neurosciences
- Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
Portuguese | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) | |
English | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) |
Education
Degree | Classification | |
---|---|---|
2017/09/26 - 2022/01/26
Concluded
|
Doutoramento em Ciências Biomédicas (Doutoramento)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
"Stress granules in Polyglutamine diseases: new targets for therapeutic intervention?" (THESIS/DISSERTATION)
|
Aprovado com Muito Bom com Distinção e Louvor |
2021/02/05 - 2021/05/14
Concluded
|
StartUp Research (Pós-Graduação)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
|
Aprovado |
2014/09 - 2016/09
Concluded
|
Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
"Systemic Transplantation of Mesenchymal Stromal Cells: a therapeutic strategy for Machado-Joseph Disease?" (THESIS/DISSERTATION)
|
18 |
2011/09 - 2014/07
Concluded
|
Ciências Biomédicas (Licenciatura)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
"Caracterização de um novo polímero híbrido" (THESIS/DISSERTATION)
|
15 |
Affiliation
Science
Category Host institution |
Employer | |
---|---|---|
2022/06/01 - Current | Postdoc (Research) | Universidade do Algarve Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal |
Teaching in Higher Education
Category Host institution |
Employer | |
---|---|---|
2022/04/18 - 2022/10/17 | Invited Assistant (University Teacher) | Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal |
Others
Category Host institution |
Employer | |
---|---|---|
2017/10/01 - 2021/11/30 | Bolseiro de Doutoramento FCT | Fundação para a Ciência e a Tecnologia, Portugal |
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal (...) |
||
2017/04/01 - 2017/09/30 | Bolseiro de Investigação para Mestre (BIM) | Universidade do Algarve, Portugal |
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal |
Projects
Grant
Designation | Funders | |
---|---|---|
2017/10/01 - 2021/11/30 | Stress granules in Polyglutamine diseases: new targets for therapeutic intervention
SFRH/BD/133192/2017
PhD Student Fellow
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
Fundação para a Ciência e a Tecnologia
Ongoing
|
2017/04/01 - 2017/09/30 | Ataxin-2 as a new molecular target in Machado-Joseph disease: from translation regulation to disease alleviation
18876
Research Fellow
Universidade do Algarve, Portugal
|
AFM-Téléthon
Concluded
|
Contract
Designation | Funders | |
---|---|---|
2022/06/01 - Current | CureCSB - Development of a Gene-Replacement Therapy for Cockayne Syndrome Type B
#438 CureCSB
Post-doc
|
|
2018/10/13 - 2021/10/12 | O papel dos grânulos de stress nas doenças de poliglutaminas: da patogénese à terapia molecular
PTDC/MED-NEU/29480/2017
Universidade do Algarve, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
Fundação para a Ciência e a Tecnologia
Ongoing
|
2019/03 - 2021 | Overexpression of the RNA-binding protein X as a therapeutic strategy to Machado-Joseph disease and other Polyglutamine diseases
#22424
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
|
AFM-Téléthon
Ongoing
|
2020/05/11 - 2020/08/11 | Development of a new assay do detect SARS-CoV-2 directly from clinical samples
126_596760136
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2018/01 - 2019/12 | Neuroprotective therapeutic approach for Spinocerebellar Ataxia type 2: pharmacological targeting of AMPK.
ZUNIALGA
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
|
Ataxia UK
Concluded
|
Outputs
Publications
Conference poster |
|
Journal article |
|
Preprint |
|
Intellectual property
Patent |
|
Other
Other output |
|
Activities
Oral presentation
Presentation title | Event name Host (Event location) |
|
---|---|---|
2022/02/11 | Upregulation of autophagy as a therapeutic strategy for SCA2 disease | 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of the Clinical Pharmacology and 21st Meeting of the
Toxicology
Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (Porto, Portugal)
|
2022/02/09 | The stress granule protein G3BP1 expression reverts pathological defects in two different polyglutamine diseases | 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of the Clinical Pharmacology and 21st Meeting of the
Toxicology
Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (Porto, Portugal)
|
2021/02/17 | Mapping the domains of RBP X towards mitigation of the pathological phenotype in Polyglutamine disease models | 51st Meeting of the Portuguese Society of Pharmacology, 39th Meeting of the Clinical Pharmacology and 20th Meeting of the
Toxicology
Faculdade de Farmácia, Universidade de Lisboa
|
2021/02 | Autophagy Dysfunction in Spinocerebellar Ataxia Type 2 Models and a Potential Therapeutic Strategy | 51 st Meeting of the Portuguese Society of Pharmacology, 39 th Meeting of the Clinical Pharmacology and 20 th Meeting of the
Toxicology
Universidade de Lisboa
|
2021/02 | RBP-X protein mitigates motor deficits in different mice models of Polyglutamine diseases | 51 st Meeting of the Portuguese Society of Pharmacology, 39 th Meeting of the Clinical Pharmacology and 20 th Meeting of the Toxicology |
2021/02 | Mapping the domains of RBP-X towards mitigation of the pathological phenotype in Polyglutamine disease models | 51 st Meeting of the Portuguese Society of Pharmacology, 39 th Meeting of the Clinical Pharmacology and 20 th Meeting of the Toxicology |
2021/02 | The stress granule protein G3BP1 expression reverts pathological defects in two different polyglutamine diseases | 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of the Clinical Pharmacology and 21st Meeting of the
Toxicology
Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (Porto, Portugal)
|
2021/02 | Upregulation of autophagy as a therapeutic strategy for SCA2 disease | 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of the Clinical Pharmacology and 21st Meeting of the
Toxicology
Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (Porto, Portugal)
|
2020/02/07 | RNA-binding proteins as potential therapeutic targets for Polyglutamine diseases. | L Reunião Anual da Sociedade Portuguesa Farmacologia, Coimbra, Portugal
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
|
2020/02/06 | Stress granules crosstalk with autophagy in the context of polyglutamine diseases. | L Reunião Anual da Sociedade Portuguesa Farmacologia
Sociedade Portuguesa Farmacologia (Coimbra, Portugal)
|
2020/01/24 | Stress granules dynamics in polyglutamine diseases. | International Meeting of the Portuguese Society of Genetics (IMPSG2020)
Sociedade Portuguesa de Genética (Faro, Portugal)
|
2019/12 | MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go? | Center for Innovative Biomedicine and Biotechnology (CIIB) Meeting
(Coimbra, Portugal)
|
2019/11/14 | CYP46A1 - gene therapy improves Machado-Joseph disease in mouse models. | 23ª Reunião Anual da Sociedade Portuguesa de Genética Humana
Sociedade Portuguesa de Genética Humana (Coimbra, Portugal)
|
2019/10 | Spectroscopic Biomarkers as a Way of Monitoring MSC Success in Promoting Neuropathological and Phenotypic Ameliorations in Machado-Joseph Disease Models | 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE TC)
(Lisboa, Portugal)
|
2019/05 | Repeated transplantation of mesenchymal stromal cells in Machado-Joseph Disease/Spinocerebelar ataxia type 3 can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy | 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
(Coimbra, Portugal)
|
2019/03/29 | Development and characterization of a lentiviral mouse model for spinocerebellar ataxia type 2. | 3as Jornadas do Algarve Biomedical Center (ABC)
Algarve Biomedical Center (ABC) (Albufeira, Portugal)
|
2019/02 | CYP46A1 overexpression alleviates Machado Joseph disease | XLIX Reunião Anual da Sociedade de Farmacologia
(Porto)
|
2018/10 | CYP46A1 - Gene therapy alleviates spinocerebellar ataxia in mouse models | 26 th Congress of the European Society of Gene and Cell Therapy (ESGCT)
(Lausanne)
|
2018/03 | Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebelar ataxia type 3 AND therapeutic success can be monitored by 1H-MRS | SPDMov 2018 Meeting - “Genética nas Doenças do Movimento”
(Curia, Portugal)
|
2018/02/06 | Pharmacological targeting of AMPK signalling pathway as a therapeutic approach to Polyglutamine diseases. | XLVIII Reunião Anual da Sociedade Portuguesa Farmacologia
Sociedade Portuguesa Farmacologia (Lisboa, Portugal)
|
2018/02 | Repeated mesenchymal stromal cells treatment sustainably alleviates Machado Joseph disease | XLVIII Reunião Anual da Sociedade Portuguesa Farmacologia
(Lisboa, Portugal)
|
2017/11/17 | Role of RNA binding proteins in polyglutamine diseases. | 21ª Reunião Anual da Sociedade Portuguesa de Genética Humana
Sociedade Portuguesa de Genética Humana (Caparica, Portugal)
|
2017/09/08 | Targeting AMPK as a therapeutic strategy to spinocerebellar ataxias. | 2nd CBMR/ProRegeM Meeting
Centro de Investigação em Biomedicina (CBMR) (Faro, Portugal)
|
Supervision
Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
---|---|---|
2021/04 - 2021/07 | Estudo do papel do componente dos grânulos de stress CARHSP1 nas doenças de Poliglutaminas
Supervisor
|
Ciências Biomédicas (Degree)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
|
2020/04/01 - 2020/07 | Alvos terapêuticos para a ataxia espinocerebelosa do tipo 2: o que foi feito?
Co-supervisor
|
Ciências Biomédicas (Degree)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
|
Association member
Society Organization name | Role | |
---|---|---|
2020/01 - Current | International Society for Neurochemistry (ISN) | |
2020/01 - Current | Sociedade Portuguesa de Genética (SPG) | |
2019/05 - Current | Sociedade Portuguesa de Neurociências (SPN) | |
2018/01 - Current | European Society for Neurochemistry (ESN) |
Distinctions
Award
2021 | SPN2021 Scholarship
Sociedade Portuguesa de Neurociências, Portugal
|
2021 | StartUp Research Post-Graduation Program Attendance Scholarship
Câmara Municipal de Oeiras, Portugal
|
2020 | Prémio Professor Doutor Luís Archer para Melhor Poster
Sociedade Portuguesa de Genética, Portugal
|
2020 | FENS Grant and Voucher Programme grant
Federation of European Neuroscience Societies, Belgium
|
2017 | PhD fellowship (SFRH/BD/133192/2017)
Fundação para a Ciência e a Tecnologia, Portugal
|